ZFPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.35512145
2protein maturation by protein folding (GO:0022417)6.43670782
3negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.08373496
4proteasome assembly (GO:0043248)4.64369921
5formation of translation preinitiation complex (GO:0001731)4.57495639
6ribosomal small subunit assembly (GO:0000028)4.19101308
7telomere maintenance via semi-conservative replication (GO:0032201)4.18485580
8deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.09674521
9pentose-phosphate shunt (GO:0006098)4.02740323
10retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.99210621
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.96512446
12GDP-mannose metabolic process (GO:0019673)3.95763872
13DNA strand elongation involved in DNA replication (GO:0006271)3.94010831
14virion assembly (GO:0019068)3.92501663
15negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.91574204
16viral mRNA export from host cell nucleus (GO:0046784)3.87513765
17proline biosynthetic process (GO:0006561)3.81823700
18pentose metabolic process (GO:0019321)3.81345917
19peptidyl-arginine omega-N-methylation (GO:0035247)3.80721498
20regulation of mitochondrial translation (GO:0070129)3.80638050
21DNA strand elongation (GO:0022616)3.79214693
22glucose catabolic process (GO:0006007)3.73473118
23regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.72029387
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.71569597
25telomere maintenance via recombination (GO:0000722)3.69903639
26NADPH regeneration (GO:0006740)3.63202635
27anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.62220937
28negative regulation of ligase activity (GO:0051352)3.61366079
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.61366079
30galactose catabolic process (GO:0019388)3.56569629
31pseudouridine synthesis (GO:0001522)3.56400716
32Golgi transport vesicle coating (GO:0048200)3.54031135
33COPI coating of Golgi vesicle (GO:0048205)3.54031135
34protein deneddylation (GO:0000338)3.53550253
35cullin deneddylation (GO:0010388)3.52980668
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.49341093
37nucleobase biosynthetic process (GO:0046112)3.48768845
38signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.44810480
39signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.44810480
40signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.44810480
41purine nucleobase biosynthetic process (GO:0009113)3.43641165
42maturation of SSU-rRNA (GO:0030490)3.42464407
43ribosome biogenesis (GO:0042254)3.42317471
44intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.41613100
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.41613100
46nuclear envelope reassembly (GO:0031468)3.41084482
47mitotic nuclear envelope reassembly (GO:0007084)3.41084482
48viral protein processing (GO:0019082)3.40656024
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.40321446
50folic acid-containing compound biosynthetic process (GO:0009396)3.37038305
51metallo-sulfur cluster assembly (GO:0031163)3.37021301
52iron-sulfur cluster assembly (GO:0016226)3.37021301
53pyrimidine-containing compound salvage (GO:0008655)3.37014907
54pyrimidine nucleoside salvage (GO:0043097)3.37014907
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.35064090
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.35064090
57barbed-end actin filament capping (GO:0051016)3.34510315
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.30710116
59signal transduction involved in cell cycle checkpoint (GO:0072395)3.30617311
60L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.28757536
61negative regulation of cell size (GO:0045792)3.27646256
62SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.26097019
63telomere maintenance via telomere lengthening (GO:0010833)3.25894885
64regulation of cellular amino acid metabolic process (GO:0006521)3.25824837
65signal peptide processing (GO:0006465)3.25646833
66DNA replication initiation (GO:0006270)3.22721059
67mitotic recombination (GO:0006312)3.19348107
68pteridine-containing compound biosynthetic process (GO:0042559)3.17684650
69antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.17639602
70positive regulation of ligase activity (GO:0051351)3.16128341
71lipopolysaccharide biosynthetic process (GO:0009103)3.15201065
72DNA replication checkpoint (GO:0000076)3.13294256
73histone arginine methylation (GO:0034969)3.12893077
74protein targeting to ER (GO:0045047)3.10973821
75cotranslational protein targeting to membrane (GO:0006613)3.10566511
76heme biosynthetic process (GO:0006783)3.09836647
77pyrimidine nucleotide catabolic process (GO:0006244)3.06035099
78transcription elongation from RNA polymerase III promoter (GO:0006385)3.05588280
79termination of RNA polymerase III transcription (GO:0006386)3.05588280
80translation (GO:0006412)3.04730569
81maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.02390792
82nucleotide-excision repair, DNA gap filling (GO:0006297)3.01153891
83ribonucleoprotein complex biogenesis (GO:0022613)3.00828149
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98921751
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98921751
86NADH metabolic process (GO:0006734)2.98592114
87protein localization to endoplasmic reticulum (GO:0070972)2.98016513
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.97654396
89nucleobase-containing small molecule interconversion (GO:0015949)2.97556752
90protein retention in ER lumen (GO:0006621)2.97059592
91UV protection (GO:0009650)2.96969386
92replication fork processing (GO:0031297)2.96830422
93regulation of ubiquitin-protein transferase activity (GO:0051438)2.96214685
94positive regulation of cell cycle arrest (GO:0071158)2.96151828
95amyloid precursor protein catabolic process (GO:0042987)2.95547066
96viral transcription (GO:0019083)2.95467319
97transcription-coupled nucleotide-excision repair (GO:0006283)2.95383712
98translational elongation (GO:0006414)2.94466458
99translational initiation (GO:0006413)2.91092951
100pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89750237
101peptidyl-arginine methylation (GO:0018216)2.89736948
102peptidyl-arginine N-methylation (GO:0035246)2.89736948
103maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89570276
104establishment of protein localization to endoplasmic reticulum (GO:0072599)2.89322656
105spliceosomal snRNP assembly (GO:0000387)2.87442289
106nucleotide salvage (GO:0043173)2.85866767
107regulation of ligase activity (GO:0051340)2.85461076
108translational termination (GO:0006415)2.84781121
109positive regulation of TOR signaling (GO:0032008)2.84579965
110base-excision repair, AP site formation (GO:0006285)2.84309015
111type B pancreatic cell proliferation (GO:0044342)2.84220026
112negative regulation of DNA-templated transcription, elongation (GO:0032785)2.83775397
113nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83402210
114G1/S transition of mitotic cell cycle (GO:0000082)2.82556091
115cell cycle G1/S phase transition (GO:0044843)2.82556091
116lipopolysaccharide metabolic process (GO:0008653)2.81929813
1177-methylguanosine mRNA capping (GO:0006370)2.81566892
118DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.81441952
119maintenance of protein localization in organelle (GO:0072595)2.80979450
120kinetochore assembly (GO:0051382)2.80676433
121endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.79135171
1222-deoxyribonucleotide biosynthetic process (GO:0009265)2.79023815
123deoxyribose phosphate biosynthetic process (GO:0046385)2.79023815
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79002825
125L-methionine salvage (GO:0071267)2.77537409
126L-methionine biosynthetic process (GO:0071265)2.77537409
127amino acid salvage (GO:0043102)2.77537409
128regulation of vacuole organization (GO:0044088)2.77037633
129regulation of nuclear cell cycle DNA replication (GO:0033262)2.75073943
130rRNA processing (GO:0006364)2.73314805
131heme metabolic process (GO:0042168)2.73068610
132negative regulation of mitochondrion organization (GO:0010823)2.73067989
133galactose metabolic process (GO:0006012)2.72964419
134regulation of autophagic vacuole assembly (GO:2000785)2.72924818
135ribosomal large subunit biogenesis (GO:0042273)2.72746016
136oxidative phosphorylation (GO:0006119)2.72362793
137regulation of release of cytochrome c from mitochondria (GO:0090199)2.71977294
1384-hydroxyproline metabolic process (GO:0019471)2.71022275
139positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.69198860
140pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.69025545
141activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.68524754
142mitochondrial DNA metabolic process (GO:0032042)2.67948377
1437-methylguanosine RNA capping (GO:0009452)2.67290756
144RNA capping (GO:0036260)2.67290756
145amino sugar catabolic process (GO:0046348)2.66447555
146NIK/NF-kappaB signaling (GO:0038061)2.63841511
147monosaccharide biosynthetic process (GO:0046364)2.63384494
148positive regulation of Cdc42 GTPase activity (GO:0043089)2.59318506
149deoxyribonucleotide catabolic process (GO:0009264)2.57946092
150positive regulation of nuclease activity (GO:0032075)2.56575649
151regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.56532977
152extracellular fibril organization (GO:0043206)2.55578851
153activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.55088194
154protein targeting to mitochondrion (GO:0006626)2.54783546
155positive regulation of actin filament depolymerization (GO:0030836)2.53681792
156nucleoside salvage (GO:0043174)2.53384518
157glucose 6-phosphate metabolic process (GO:0051156)2.51090154
158negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.51045503
159tRNA methylation (GO:0030488)2.50811453
160peptidyl-proline hydroxylation (GO:0019511)2.50382803
161regulation of mammary gland epithelial cell proliferation (GO:0033599)2.49055494
162L-phenylalanine metabolic process (GO:0006558)2.44999675
163erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.44999675
164modulation by virus of host process (GO:0019054)2.44770768
165GMP metabolic process (GO:0046037)2.40984621
166deoxyribose phosphate catabolic process (GO:0046386)2.40799409
167mannosylation (GO:0097502)2.39956073
168activation of MAPKKK activity (GO:0000185)2.39553351
169gluconeogenesis (GO:0006094)2.39459979
170protein insertion into membrane (GO:0051205)2.36196162
171Arp2/3 complex-mediated actin nucleation (GO:0034314)2.35716389
172pinocytosis (GO:0006907)2.35423631
173positive regulation of mitochondrial fission (GO:0090141)2.35309356
174positive regulation of lipoprotein lipase activity (GO:0051006)2.35200162
175positive regulation of triglyceride lipase activity (GO:0061365)2.35200162
176establishment of protein localization to mitochondrion (GO:0072655)2.34014661
177NADP metabolic process (GO:0006739)2.33457643
178endoplasmic reticulum unfolded protein response (GO:0030968)2.33292940
179tricarboxylic acid metabolic process (GO:0072350)2.32300563
180protein localization to endosome (GO:0036010)2.30097839
181purine ribonucleotide transport (GO:0015868)2.29856643
182protein hydroxylation (GO:0018126)2.29837397

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.13933643
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70072497
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.68376921
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.47823014
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.20571160
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18697254
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.11714650
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.02821221
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.02229407
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88139317
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.65364488
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58712555
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.53514874
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53034651
15* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40286666
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.38955146
17ZNF263_19887448_ChIP-Seq_K562_Human2.38019410
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35619072
19* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19966191
20E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18890611
21XRN2_22483619_ChIP-Seq_HELA_Human2.16952434
22* VDR_23849224_ChIP-Seq_CD4+_Human2.16769703
23GABP_19822575_ChIP-Seq_HepG2_Human2.16485318
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16121300
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14665214
26DCP1A_22483619_ChIP-Seq_HELA_Human2.09545298
27ELK3_25401928_ChIP-Seq_HUVEC_Human2.07415155
28* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04931971
29* LXR_22292898_ChIP-Seq_THP-1_Human2.04613385
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02665243
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02321642
32YY1_21170310_ChIP-Seq_MESCs_Mouse2.01093420
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94768363
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94216016
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91360979
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.89658506
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.88986943
38FOXP3_21729870_ChIP-Seq_TREG_Human1.88381678
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86454292
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82568890
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81267869
42* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77770552
43CIITA_25753668_ChIP-Seq_RAJI_Human1.77024716
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.74287600
45RACK7_27058665_Chip-Seq_MCF-7_Human1.73610617
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68458188
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68117037
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64789270
49TTF2_22483619_ChIP-Seq_HELA_Human1.62189484
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60641776
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.60358756
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59889914
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59832329
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59604384
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58748368
56P68_20966046_ChIP-Seq_HELA_Human1.57243206
57MYC_22102868_ChIP-Seq_BL_Human1.55812184
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.54186195
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52809096
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51696461
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50392993
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48522000
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.47554218
64* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47035278
65BCL6_27268052_Chip-Seq_Bcells_Human1.46040280
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44371313
67TFEB_21752829_ChIP-Seq_HELA_Human1.44324515
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41519322
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40304732
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.40138382
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38838642
72KDM5A_27292631_Chip-Seq_BREAST_Human1.38621311
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37338324
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34378071
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.33268228
76TP63_17297297_ChIP-ChIP_HaCaT_Human1.32762163
77* BCOR_27268052_Chip-Seq_Bcells_Human1.31763175
78* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30327783
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29737911
80VDR_21846776_ChIP-Seq_THP-1_Human1.28630934
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.28103782
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27191446
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24667560
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24655522
85* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24179345
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22510556
87ELK1_19687146_ChIP-ChIP_HELA_Human1.22250768
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21336529
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21083834
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21032623
91ATF3_27146783_Chip-Seq_COLON_Human1.20570670
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18010315
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17641919
94ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.16993707
95CTCF_26484167_Chip-Seq_Bcells_Mouse1.16731436
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15585442
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15445022
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14109204
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11782160
100ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11656612
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11375350
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10675675
103* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09694987
104NCOR1_26117541_ChIP-Seq_K562_Human1.09392947
105MAF_26560356_Chip-Seq_TH2_Human1.09235782
106TET1_21451524_ChIP-Seq_MESCs_Mouse1.09188790
107ELK1_22589737_ChIP-Seq_MCF10A_Human1.08231888
108PHF8_20622854_ChIP-Seq_HELA_Human1.08011908
109RARB_24833708_ChIP-Seq_LIVER_Mouse1.06916083
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06831158
111SPI1_23547873_ChIP-Seq_NB4_Human1.06601416
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06055972
113TP63_19390658_ChIP-ChIP_HaCaT_Human1.05803620
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05732699
115SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05449492
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04075898
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03731790
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03563627
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03400131
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02793005
121KDM2B_26808549_Chip-Seq_DND41_Human1.02099440
122AR_21909140_ChIP-Seq_LNCAP_Human1.01820293
123TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01556115
124* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97716411
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95691405
126PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94828205
127POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94444381
128GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93544652
129TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93424583
130EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91486191
131CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89830177
132YY1_22570637_ChIP-Seq_MALME-3M_Human0.89767291
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88750151
134SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88089562
135* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87865476
136CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86448901
137* FOXP1_21924763_ChIP-Seq_HESCs_Human0.86114590
138TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85350437
139IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.83820192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.31545434
2MP0005451_abnormal_body_composition3.96851131
3MP0003191_abnormal_cellular_cholesterol3.85032038
4MP0004957_abnormal_blastocyst_morpholog3.79987572
5MP0003111_abnormal_nucleus_morphology3.19943225
6MP0006054_spinal_hemorrhage2.77260691
7MP0008007_abnormal_cellular_replicative2.75662199
8MP0003077_abnormal_cell_cycle2.75437253
9MP0010094_abnormal_chromosome_stability2.62205501
10MP0008058_abnormal_DNA_repair2.51669342
11MP0003806_abnormal_nucleotide_metabolis2.47361130
12MP0000013_abnormal_adipose_tissue2.41786127
13MP0008932_abnormal_embryonic_tissue2.35288005
14MP0008438_abnormal_cutaneous_collagen2.17444840
15MP0000490_abnormal_crypts_of2.12373679
16MP0005501_abnormal_skin_physiology1.98532641
17MP0010352_gastrointestinal_tract_polyps1.97032017
18MP0008057_abnormal_DNA_replication1.93165080
19MP0004858_abnormal_nervous_system1.90755900
20MP0002396_abnormal_hematopoietic_system1.89221484
21MP0005257_abnormal_intraocular_pressure1.82791051
22MP0003705_abnormal_hypodermis_morpholog1.75832794
23MP0009333_abnormal_splenocyte_physiolog1.70764084
24MP0005220_abnormal_exocrine_pancreas1.65681998
25MP0010030_abnormal_orbit_morphology1.63460741
26MP0004510_myositis1.59883807
27MP0003786_premature_aging1.59435223
28MP0003186_abnormal_redox_activity1.54408573
29MP0003566_abnormal_cell_adhesion1.51757382
30MP0003075_altered_response_to1.51622527
31MP0001545_abnormal_hematopoietic_system1.50706876
32MP0005397_hematopoietic_system_phenotyp1.50706876
33MP0004133_heterotaxia1.50151149
34MP0003763_abnormal_thymus_physiology1.50051149
35MP0001730_embryonic_growth_arrest1.49106000
36MP0008789_abnormal_olfactory_epithelium1.48765257
37MP0005075_abnormal_melanosome_morpholog1.45937265
38MP0002796_impaired_skin_barrier1.45916147
39MP0000350_abnormal_cell_proliferation1.45380235
40MP0005360_urolithiasis1.43068253
41MP0001849_ear_inflammation1.42555450
42MP0002653_abnormal_ependyma_morphology1.42018049
43MP0000751_myopathy1.40552276
44MP0000343_altered_response_to1.37029645
45MP0005058_abnormal_lysosome_morphology1.36819244
46MP0002877_abnormal_melanocyte_morpholog1.36755682
47MP0000313_abnormal_cell_death1.36446920
48MP0000678_abnormal_parathyroid_gland1.33990640
49MP0001905_abnormal_dopamine_level1.33910151
50MP0000750_abnormal_muscle_regeneration1.33181159
51MP0002019_abnormal_tumor_incidence1.33149464
52MP0005084_abnormal_gallbladder_morpholo1.32732138
53MP0000858_altered_metastatic_potential1.32507088
54MP0001697_abnormal_embryo_size1.32288744
55MP0000358_abnormal_cell_content/1.31123205
56MP0003329_amyloid_beta_deposits1.30608044
57MP0003718_maternal_effect1.24506060
58MP0002080_prenatal_lethality1.23435176
59MP0004233_abnormal_muscle_weight1.22927431
60MP0003123_paternal_imprinting1.18310441
61MP0001727_abnormal_embryo_implantation1.18300736
62MP0003119_abnormal_digestive_system1.17443172
63MP0001672_abnormal_embryogenesis/_devel1.15623932
64MP0005380_embryogenesis_phenotype1.15623932
65MP0004272_abnormal_basement_membrane1.14016983
66MP0000681_abnormal_thyroid_gland1.13871729
67MP0002722_abnormal_immune_system1.13304307
68MP0002160_abnormal_reproductive_system1.12786272
69MP0000685_abnormal_immune_system1.11575332
70MP0001764_abnormal_homeostasis1.11291079
71MP0000703_abnormal_thymus_morphology1.10964667
72MP0005083_abnormal_biliary_tract1.06935344
73MP0001986_abnormal_taste_sensitivity1.06703482
74MP0003984_embryonic_growth_retardation1.06575816
75MP0003453_abnormal_keratinocyte_physiol1.06530560
76MP0002398_abnormal_bone_marrow1.05696015
77MP0005389_reproductive_system_phenotype1.04895492
78MP0002332_abnormal_exercise_endurance1.03713601
79MP0000689_abnormal_spleen_morphology1.03250628
80MP0002088_abnormal_embryonic_growth/wei1.02758987
81MP0000465_gastrointestinal_hemorrhage1.01936621
82MP0006036_abnormal_mitochondrial_physio1.01506209
83MP0004808_abnormal_hematopoietic_stem1.00798672
84MP0005330_cardiomyopathy0.99556165
85MP0005165_increased_susceptibility_to0.99228019
86MP0001919_abnormal_reproductive_system0.99150926
87MP0001835_abnormal_antigen_presentation0.98566363
88MP0002693_abnormal_pancreas_physiology0.98320618
89MP0003656_abnormal_erythrocyte_physiolo0.97166267
90MP0001944_abnormal_pancreas_morphology0.97054775
91MP0002086_abnormal_extraembryonic_tissu0.96789410
92MP0002085_abnormal_embryonic_tissue0.96284077
93MP0005670_abnormal_white_adipose0.95649475
94MP0010386_abnormal_urinary_bladder0.94338303
95MP0002429_abnormal_blood_cell0.94283591
96MP0003436_decreased_susceptibility_to0.94181060
97MP0002132_abnormal_respiratory_system0.93728130
98MP0002822_catalepsy0.93250574
99MP0006082_CNS_inflammation0.93027169
100MP0003303_peritoneal_inflammation0.92972063
101MP0001533_abnormal_skeleton_physiology0.92621307
102MP0005394_taste/olfaction_phenotype0.91822687
103MP0005499_abnormal_olfactory_system0.91822687
104MP0005671_abnormal_response_to0.91567171
105MP0006035_abnormal_mitochondrial_morpho0.91301846
106MP0000749_muscle_degeneration0.88155762
107MP0002419_abnormal_innate_immunity0.87333678
108MP0002148_abnormal_hypersensitivity_rea0.86906136
109MP0003567_abnormal_fetal_cardiomyocyte0.86516691
110MP0005584_abnormal_enzyme/coenzyme_acti0.86466869
111MP0008469_abnormal_protein_level0.86183027
112MP0009840_abnormal_foam_cell0.85999379
113MP0002060_abnormal_skin_morphology0.84622429
114MP0003279_aneurysm0.84477783
115MP0002163_abnormal_gland_morphology0.84312347
116MP0005023_abnormal_wound_healing0.84241964
117MP0005025_abnormal_response_to0.83879507
118MP0005319_abnormal_enzyme/_coenzyme0.83129214
119MP0005390_skeleton_phenotype0.82582108
120MP0009384_cardiac_valve_regurgitation0.82291287
121MP0004264_abnormal_extraembryonic_tissu0.82235303
122MP0003172_abnormal_lysosome_physiology0.82090025
123MP0001853_heart_inflammation0.81200186
124MP0001119_abnormal_female_reproductive0.81096695
125MP0000716_abnormal_immune_system0.81069429
126MP0010771_integument_phenotype0.81014812
127MP0009931_abnormal_skin_appearance0.80728403
128MP0006292_abnormal_olfactory_placode0.79466714
129MP0010234_abnormal_vibrissa_follicle0.79271690
130MP0005384_cellular_phenotype0.78585322
131MP0009278_abnormal_bone_marrow0.78361229
132MP0008260_abnormal_autophagy0.77774863
133MP0002970_abnormal_white_adipose0.77585988
134MP0000003_abnormal_adipose_tissue0.77121488
135MP0004147_increased_porphyrin_level0.76981355
136MP0000613_abnormal_salivary_gland0.76963464
137MP0000604_amyloidosis0.76916968
138MP0002938_white_spotting0.76597991
139MP0005367_renal/urinary_system_phenotyp0.75900071
140MP0000516_abnormal_urinary_system0.75900071
141MP0008874_decreased_physiological_sensi0.75512173
142MP0003943_abnormal_hepatobiliary_system0.74973183
143MP0005464_abnormal_platelet_physiology0.74188681
144MP0004197_abnormal_fetal_growth/weight/0.73654589
145MP0001243_abnormal_dermal_layer0.73637248
146MP0002084_abnormal_developmental_patter0.73531162
147MP0003890_abnormal_embryonic-extraembry0.73116740
148MP0004185_abnormal_adipocyte_glucose0.72486540
149MP0002933_joint_inflammation0.72426742
150MP0001186_pigmentation_phenotype0.72183540
151MP0005375_adipose_tissue_phenotype0.72167362
152MP0002111_abnormal_tail_morphology0.72001156
153MP0000371_diluted_coat_color0.71292605
154MP0001881_abnormal_mammary_gland0.71176485
155MP0002127_abnormal_cardiovascular_syste0.70690141
156MP0001542_abnormal_bone_strength0.70184752
157MP0000747_muscle_weakness0.70103598
158MP0002295_abnormal_pulmonary_circulatio0.69913153
159MP0001216_abnormal_epidermal_layer0.67975803
160MP0000609_abnormal_liver_physiology0.67723369
161MP0005666_abnormal_adipose_tissue0.66961166
162MP0000538_abnormal_urinary_bladder0.66301994
163MP0004947_skin_inflammation0.65625642
164MP0005621_abnormal_cell_physiology0.65530104
165MP0002249_abnormal_larynx_morphology0.65042453
166MP0002139_abnormal_hepatobiliary_system0.63308881

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of anterior horn cells (HP:0002398)3.97042230
2Abnormality of the anterior horn cell (HP:0006802)3.97042230
311 pairs of ribs (HP:0000878)3.96847751
4Cholecystitis (HP:0001082)3.96815559
5Abnormal gallbladder physiology (HP:0012438)3.96815559
6Birth length less than 3rd percentile (HP:0003561)3.57485041
7Rough bone trabeculation (HP:0100670)3.52963817
8Premature rupture of membranes (HP:0001788)3.35109337
9Type I transferrin isoform profile (HP:0003642)3.27971813
10Aplastic anemia (HP:0001915)3.27817682
11Hypertensive crisis (HP:0100735)3.27622185
12Abnormality of glycolipid metabolism (HP:0010969)3.11829156
13Abnormality of liposaccharide metabolism (HP:0010968)3.11829156
14Abnormality of glycosphingolipid metabolism (HP:0004343)3.11829156
15Vertebral compression fractures (HP:0002953)3.03175532
16Poor head control (HP:0002421)2.98432514
17Achilles tendon contracture (HP:0001771)2.96947554
18Reticulocytopenia (HP:0001896)2.94647727
19Patellar aplasia (HP:0006443)2.88442809
20Distal upper limb amyotrophy (HP:0007149)2.84059789
21Upper limb amyotrophy (HP:0009129)2.84059789
22Hepatic necrosis (HP:0002605)2.81124008
23Hepatocellular necrosis (HP:0001404)2.79094660
24Breast hypoplasia (HP:0003187)2.76359021
25Cervical subluxation (HP:0003308)2.75085541
26Abnormal protein glycosylation (HP:0012346)2.74916978
27Abnormal glycosylation (HP:0012345)2.74916978
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.74916978
29Abnormal protein N-linked glycosylation (HP:0012347)2.74916978
30Oral leukoplakia (HP:0002745)2.73247514
31Microvesicular hepatic steatosis (HP:0001414)2.72921754
32Abnormality of cells of the erythroid lineage (HP:0012130)2.72853489
33Reduced antithrombin III activity (HP:0001976)2.72605616
34Abnormal number of erythroid precursors (HP:0012131)2.71817218
35Selective tooth agenesis (HP:0001592)2.71160213
36Aplasia/Hypoplasia of the patella (HP:0006498)2.70538513
37Hand muscle atrophy (HP:0009130)2.69067930
38Reticulocytosis (HP:0001923)2.67854833
39Distal lower limb muscle weakness (HP:0009053)2.67530613
40Abnormality of the Achilles tendon (HP:0005109)2.66813410
41Thrombocytosis (HP:0001894)2.64288413
42Ragged-red muscle fibers (HP:0003200)2.62249759
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.61564867
44Abnormal trabecular bone morphology (HP:0100671)2.57409579
45Hepatosplenomegaly (HP:0001433)2.57360037
46Upper limb muscle weakness (HP:0003484)2.56874955
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.56500466
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.56500466
49Slender long bone (HP:0003100)2.55013389
50Vacuolated lymphocytes (HP:0001922)2.54029459
51Atrophy/Degeneration involving motor neurons (HP:0007373)2.52197193
52Microretrognathia (HP:0000308)2.48321118
53Dysostosis multiplex (HP:0000943)2.47471818
54Axonal loss (HP:0003447)2.46864114
55Increased serum pyruvate (HP:0003542)2.44587747
56Premature graying of hair (HP:0002216)2.44086373
57Abnormality of glycolysis (HP:0004366)2.43731480
58Hyperthyroidism (HP:0000836)2.37310318
59Missing ribs (HP:0000921)2.32649774
60Abnormality of aromatic amino acid family metabolism (HP:0004338)2.31060503
61Cerebral hypomyelination (HP:0006808)2.30258992
62Cholelithiasis (HP:0001081)2.29467825
63Bone marrow hypocellularity (HP:0005528)2.29027089
64Progressive neurologic deterioration (HP:0002344)2.28465747
65Abnormal mitochondria in muscle tissue (HP:0008316)2.27990027
66Progressive muscle weakness (HP:0003323)2.27986923
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27035461
68Abnormality of polysaccharide metabolism (HP:0011012)2.27035461
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27035461
70Muscle fiber atrophy (HP:0100295)2.25311120
71Generalized amyotrophy (HP:0003700)2.24323904
72J-shaped sella turcica (HP:0002680)2.23151846
73Hypokinesia (HP:0002375)2.22809138
74Purpura (HP:0000979)2.20893083
75Type 2 muscle fiber atrophy (HP:0003554)2.20032460
76Carpal bone hypoplasia (HP:0001498)2.19299022
77Growth hormone excess (HP:0000845)2.16913767
78Increased muscle lipid content (HP:0009058)2.16867834
79Atelectasis (HP:0100750)2.11133952
80Trismus (HP:0000211)2.10913591
81Distal lower limb amyotrophy (HP:0008944)2.08595810
82Difficulty climbing stairs (HP:0003551)2.08436033
83Abnormality of the umbilical cord (HP:0010881)2.07401303
84Absent thumb (HP:0009777)2.05901216
85Abnormality of the tricuspid valve (HP:0001702)2.05838234
86Breech presentation (HP:0001623)2.05266547
87Joint stiffness (HP:0001387)2.04518516
88Generalized aminoaciduria (HP:0002909)2.03456124
89Increased serum ferritin (HP:0003281)2.02904325
90Emotional lability (HP:0000712)2.02307794
91Increased connective tissue (HP:0009025)2.01368066
92Unsteady gait (HP:0002317)2.01181918
93Mucopolysacchariduria (HP:0008155)2.00730004
94Urinary glycosaminoglycan excretion (HP:0003541)2.00730004
95Biconcave vertebral bodies (HP:0004586)1.99341790
96Mitochondrial inheritance (HP:0001427)1.98801849
97Pancytopenia (HP:0001876)1.98333295
98Increased serum lactate (HP:0002151)1.96819800
99Abnormal gallbladder morphology (HP:0012437)1.96626938
100Myopathic facies (HP:0002058)1.96308833
101Abnormality of the ileum (HP:0001549)1.95757575
102Abnormality of reticulocytes (HP:0004312)1.95717087
103Loss of speech (HP:0002371)1.94887657
104Centrally nucleated skeletal muscle fibers (HP:0003687)1.94765000
105Stridor (HP:0010307)1.94034892
106Abnormality of the heme biosynthetic pathway (HP:0010472)1.93845681
107Athetosis (HP:0002305)1.91993270
108Flattened epiphyses (HP:0003071)1.91610762
109Cerebral palsy (HP:0100021)1.90634979
110Myelodysplasia (HP:0002863)1.88710333
111Premature ovarian failure (HP:0008209)1.88439937
112Increased intramyocellular lipid droplets (HP:0012240)1.87853224
113Delusions (HP:0000746)1.86957155
114Spastic paraparesis (HP:0002313)1.86524839
115Acute encephalopathy (HP:0006846)1.85554512
116Upper motor neuron abnormality (HP:0002127)1.85476401
117Fasciculations (HP:0002380)1.85137522
118Increased CSF lactate (HP:0002490)1.84805364
119Secondary amenorrhea (HP:0000869)1.84036498
120Irregular vertebral endplates (HP:0003301)1.82497611
121Short nail (HP:0001799)1.82407490
122Poikiloderma (HP:0001029)1.82388316
123Pallor (HP:0000980)1.82375875
124Flat capital femoral epiphysis (HP:0003370)1.81381895
125Acute necrotizing encephalopathy (HP:0006965)1.80876585
126Neoplasm of the pancreas (HP:0002894)1.80777425
127Elbow flexion contracture (HP:0002987)1.80017604
128Seborrheic dermatitis (HP:0001051)1.79081195
129Protrusio acetabuli (HP:0003179)1.78898943
130Spinal rigidity (HP:0003306)1.78416523
131Amyloidosis (HP:0011034)1.77863328
132Abnormality of the gallbladder (HP:0005264)1.77279061
133Nonimmune hydrops fetalis (HP:0001790)1.76334808
134Abnormality of the preputium (HP:0100587)1.75761008
135IgM deficiency (HP:0002850)1.75748478
136Basal cell carcinoma (HP:0002671)1.75188758
137Abnormal neuron morphology (HP:0012757)1.75077119
138Cellular immunodeficiency (HP:0005374)1.75060796
139Dicarboxylic aciduria (HP:0003215)1.75017894
140Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75017894
141Hypoplasia of the pons (HP:0012110)1.74590802
142Exertional dyspnea (HP:0002875)1.74527702
143Opisthotonus (HP:0002179)1.73779178
144CNS demyelination (HP:0007305)1.73240250
145Truncus arteriosus (HP:0001660)1.73033395
146Long palpebral fissure (HP:0000637)1.72636771
147Meckel diverticulum (HP:0002245)1.72212546
148Spinal cord compression (HP:0002176)1.71651444
149Pancreatic cysts (HP:0001737)1.70164685
150Optic nerve coloboma (HP:0000588)1.69943347
151Petechiae (HP:0000967)1.69572528
152Aplasia/Hypoplasia of the uvula (HP:0010293)1.68084118
153Tongue fasciculations (HP:0001308)1.67717486
154Colon cancer (HP:0003003)1.67522204
155Sparse eyelashes (HP:0000653)1.67188873
156Beaking of vertebral bodies (HP:0004568)1.66558427
157Wide cranial sutures (HP:0010537)1.66441946
158Irregular epiphyses (HP:0010582)1.66264111
159Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.66183495
160Prominent metopic ridge (HP:0005487)1.65680439
161Squamous cell carcinoma (HP:0002860)1.65069503
162Absent radius (HP:0003974)1.64088032
163Abnormal umbilical cord blood vessels (HP:0011403)1.63195086
164Single umbilical artery (HP:0001195)1.63195086
165Abnormality of the fetal cardiovascular system (HP:0010948)1.63195086
166Entropion (HP:0000621)1.62031640
167Macrocytic anemia (HP:0001972)1.60184030
168Spinal muscular atrophy (HP:0007269)1.59188117
169Insulin resistance (HP:0000855)1.58247570
170Abnormality of T cell physiology (HP:0011840)1.56723373
171Vertebral hypoplasia (HP:0008417)1.56126716
172Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.56126716
173Prolonged neonatal jaundice (HP:0006579)1.54642554
174Abnormality of the motor neurons (HP:0002450)1.54352181

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.62183770
2STK163.83647304
3NME23.78625697
4PIM23.42924063
5VRK23.16901106
6RIPK12.82573865
7EIF2AK12.66383898
8LIMK12.45459768
9FLT32.44339523
10MAP3K112.43073421
11ARAF2.28637779
12EPHA22.14077509
13SMG12.09794467
14WEE12.00370742
15DYRK31.97516378
16SIK11.94308752
17ERN11.89464709
18BRAF1.84317395
19RPS6KA41.71339302
20BCKDK1.67616729
21PASK1.63870438
22TESK21.61225704
23TAOK11.59983388
24KDR1.58008968
25EIF2AK31.56869878
26NEK11.52499701
27MAP2K31.35713084
28PRPF4B1.34155239
29TRIB31.33184259
30CDK71.30468316
31PLK41.30220807
32ACVR1B1.28139516
33SRPK11.27062617
34LMTK21.26893116
35TTK1.26060981
36TESK11.26026083
37EPHB11.26025043
38PRKD21.24846778
39TAOK21.22898325
40PAK41.18952491
41ICK1.18753223
42PLK11.18139305
43VRK11.17404165
44ZAK1.16832266
45NEK21.16540565
46ABL21.15886943
47MAPK151.14967898
48ZAP701.14194079
49MAPKAPK31.13078204
50EPHB21.10173013
51BRSK21.08950626
52DAPK31.07288597
53AURKA1.06558033
54MAP4K11.04239848
55IRAK31.01529778
56ERBB31.00351512
57BRSK10.99938423
58STK38L0.95932440
59AKT30.95489678
60CDC70.95413609
61ATR0.94793456
62SIK30.93419624
63RPS6KB20.92877495
64AURKB0.91139337
65FES0.90724509
66MAP3K10.90277839
67MAP2K70.89237853
68TGFBR10.86955477
69PIM10.86376445
70MUSK0.86248044
71PTK20.85847705
72TLK10.84689153
73FER0.84200775
74PKN20.81695678
75SCYL20.79289132
76NME10.78985327
77MATK0.78799103
78JAK30.78016025
79CSNK1G30.77469441
80IRAK20.77059727
81TBK10.75592130
82CCNB10.74798903
83DAPK10.73770858
84RAF10.72782173
85CHEK20.72556636
86RPS6KA60.71862167
87RPS6KC10.71789267
88RPS6KL10.71789267
89RPS6KA20.71287083
90MAP3K80.71058890
91PLK30.70848398
92PTK60.68038313
93CDK80.67223328
94TSSK60.67005662
95DDR20.66703525
96MYLK0.65467215
97GRK60.65111105
98PRKCI0.64683924
99BTK0.64337363
100ILK0.64225363
101PAK10.64103691
102DYRK1B0.63469371
103KIT0.62286401
104MAP2K20.59226182
105LRRK20.58556044
106MARK20.55123108
107MAP3K60.54892409
108MST1R0.54001498
109PRKD10.52535692
110IRAK40.52513459
111MAPKAPK20.52237716
112CSNK2A10.51671821
113BMX0.51125021
114MAPK110.50013650
115PBK0.49059785
116CHUK0.48747938
117HIPK20.48465207
118MAP3K120.48274983
119MAP2K60.47112250
120LATS20.46493103
121MAP3K30.45542711
122CAMK2G0.45158313
123CAMKK20.43640638
124IKBKB0.43280842
125PRKG20.40893313
126RPS6KA50.40524103
127PAK20.40382453
128AKT20.39931223
129DYRK20.39799490
130MKNK10.39422247
131MAP3K50.39219405
132PRKD30.38449359
133CSNK1A1L0.38447724
134SIK20.38295438
135CSNK1G20.36923037
136TNK20.36467646
137CHEK10.36424307
138PDGFRA0.35681162
139CDK40.35507986
140NTRK10.34204189
141TTN0.33825730
142MTOR0.30737740
143PDPK10.30250088
144PDK20.28208606

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.28080919
2DNA replication_Homo sapiens_hsa030304.26416435
3Mismatch repair_Homo sapiens_hsa034303.61907089
4Base excision repair_Homo sapiens_hsa034103.45377777
5Ribosome_Homo sapiens_hsa030103.31879344
6RNA polymerase_Homo sapiens_hsa030203.21769277
7Protein export_Homo sapiens_hsa030603.06403794
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.87429525
9Fatty acid elongation_Homo sapiens_hsa000622.80371868
10Spliceosome_Homo sapiens_hsa030402.60638059
11Pyrimidine metabolism_Homo sapiens_hsa002402.54123192
12Nucleotide excision repair_Homo sapiens_hsa034202.37425151
13RNA transport_Homo sapiens_hsa030132.35255636
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31665955
15Homologous recombination_Homo sapiens_hsa034402.26835427
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.16936320
17One carbon pool by folate_Homo sapiens_hsa006701.93043652
18Folate biosynthesis_Homo sapiens_hsa007901.88923574
19Cell cycle_Homo sapiens_hsa041101.87708148
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.76497219
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.76313933
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57046283
23Fanconi anemia pathway_Homo sapiens_hsa034601.50406342
24p53 signaling pathway_Homo sapiens_hsa041151.46808357
25RNA degradation_Homo sapiens_hsa030181.44559078
26Steroid biosynthesis_Homo sapiens_hsa001001.44464503
27Basal transcription factors_Homo sapiens_hsa030221.41080535
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35838566
29Selenocompound metabolism_Homo sapiens_hsa004501.22746059
30Purine metabolism_Homo sapiens_hsa002301.20231180
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16690082
32Salmonella infection_Homo sapiens_hsa051321.16630482
33Fructose and mannose metabolism_Homo sapiens_hsa000511.16512058
34Epstein-Barr virus infection_Homo sapiens_hsa051691.14391158
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.10762968
36N-Glycan biosynthesis_Homo sapiens_hsa005101.08030839
37Galactose metabolism_Homo sapiens_hsa000521.07993130
38Pyruvate metabolism_Homo sapiens_hsa006201.02208615
39Other glycan degradation_Homo sapiens_hsa005111.00946879
40mRNA surveillance pathway_Homo sapiens_hsa030151.00913989
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98438245
42Sulfur metabolism_Homo sapiens_hsa009200.96227745
43Peroxisome_Homo sapiens_hsa041460.93468164
44Phenylalanine metabolism_Homo sapiens_hsa003600.90659554
45Collecting duct acid secretion_Homo sapiens_hsa049660.90596905
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87484656
47Non-homologous end-joining_Homo sapiens_hsa034500.85786966
48Thyroid cancer_Homo sapiens_hsa052160.83608894
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81920237
50Parkinsons disease_Homo sapiens_hsa050120.80119586
51Sulfur relay system_Homo sapiens_hsa041220.79761101
52Antigen processing and presentation_Homo sapiens_hsa046120.79195957
53Regulation of autophagy_Homo sapiens_hsa041400.78358304
54Legionellosis_Homo sapiens_hsa051340.78149786
55Endocytosis_Homo sapiens_hsa041440.77402741
56Huntingtons disease_Homo sapiens_hsa050160.76715656
57Synaptic vesicle cycle_Homo sapiens_hsa047210.75793807
58Pentose phosphate pathway_Homo sapiens_hsa000300.73460679
59Herpes simplex infection_Homo sapiens_hsa051680.73184997
60Shigellosis_Homo sapiens_hsa051310.71778007
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.69948431
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69250783
63Oxidative phosphorylation_Homo sapiens_hsa001900.68761467
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68527791
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65173592
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.63411564
67Fatty acid metabolism_Homo sapiens_hsa012120.61904182
68Apoptosis_Homo sapiens_hsa042100.61561275
69Viral carcinogenesis_Homo sapiens_hsa052030.60873922
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60645367
71Biosynthesis of amino acids_Homo sapiens_hsa012300.59699874
72Lysosome_Homo sapiens_hsa041420.58574271
73Vibrio cholerae infection_Homo sapiens_hsa051100.56924598
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56906819
75Sphingolipid metabolism_Homo sapiens_hsa006000.56602254
76Acute myeloid leukemia_Homo sapiens_hsa052210.56583476
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55142929
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54851825
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.54408867
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.52913367
81Glutathione metabolism_Homo sapiens_hsa004800.52634145
82Pertussis_Homo sapiens_hsa051330.51029445
83HTLV-I infection_Homo sapiens_hsa051660.50281825
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50009081
85AMPK signaling pathway_Homo sapiens_hsa041520.49254111
86Phagosome_Homo sapiens_hsa041450.48682712
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48586841
88Bladder cancer_Homo sapiens_hsa052190.44331314
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43270055
90Arachidonic acid metabolism_Homo sapiens_hsa005900.42680517
91Tyrosine metabolism_Homo sapiens_hsa003500.41218662
92Primary immunodeficiency_Homo sapiens_hsa053400.40564348
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39558592
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39458172
95Prion diseases_Homo sapiens_hsa050200.39245497
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38446733
97Metabolic pathways_Homo sapiens_hsa011000.38349061
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37786014
99Measles_Homo sapiens_hsa051620.37181551
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35867358
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34343220
102Notch signaling pathway_Homo sapiens_hsa043300.33948837
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.33909087
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32558088
105Arginine and proline metabolism_Homo sapiens_hsa003300.31804947
106Hepatitis B_Homo sapiens_hsa051610.30366929
107Insulin signaling pathway_Homo sapiens_hsa049100.29890011
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28164528
109Oocyte meiosis_Homo sapiens_hsa041140.28091949
110Vitamin B6 metabolism_Homo sapiens_hsa007500.27418529
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26980284
112Hepatitis C_Homo sapiens_hsa051600.26583117
113Carbon metabolism_Homo sapiens_hsa012000.25193375
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.25176240
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22541753
116Colorectal cancer_Homo sapiens_hsa052100.22361970
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21818969
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21276528
119Rheumatoid arthritis_Homo sapiens_hsa053230.21264175
120Alzheimers disease_Homo sapiens_hsa050100.21195176
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21078754
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20708599
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.19957144
124Influenza A_Homo sapiens_hsa051640.19855154
125HIF-1 signaling pathway_Homo sapiens_hsa040660.19823282
126Tuberculosis_Homo sapiens_hsa051520.19495358
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18738113
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17322463
129Chronic myeloid leukemia_Homo sapiens_hsa052200.16372436
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14719481
131Prolactin signaling pathway_Homo sapiens_hsa049170.13500176
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11169787
133Circadian rhythm_Homo sapiens_hsa047100.10199299

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