ZFPM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)8.45335421
2protoporphyrinogen IX biosynthetic process (GO:0006782)7.59323552
3porphyrin-containing compound biosynthetic process (GO:0006779)7.26512381
4erythrocyte development (GO:0048821)7.01291019
5tetrapyrrole biosynthetic process (GO:0033014)6.45159524
6erythrocyte maturation (GO:0043249)6.40254861
7negative regulation of erythrocyte differentiation (GO:0045647)6.11192495
8porphyrin-containing compound metabolic process (GO:0006778)5.98897994
9heme biosynthetic process (GO:0006783)5.87864592
10cellular response to thyroid hormone stimulus (GO:0097067)5.73646251
11* granulocyte differentiation (GO:0030851)5.55547820
12positive regulation of fibroblast migration (GO:0010763)5.53755416
13positive regulation of histone deacetylation (GO:0031065)5.52838960
14* embryonic hemopoiesis (GO:0035162)5.52329883
15positive regulation of osteoblast proliferation (GO:0033690)5.31189986
16positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.24639722
17heme metabolic process (GO:0042168)5.04878328
18* platelet formation (GO:0030220)5.02086728
19positive regulation of erythrocyte differentiation (GO:0045648)4.94601548
20mannose metabolic process (GO:0006013)4.94157014
21* regulation of erythrocyte differentiation (GO:0045646)4.89205875
223-UTR-mediated mRNA stabilization (GO:0070935)4.78816411
23negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.74770228
24maternal placenta development (GO:0001893)4.68197915
25tolerance induction (GO:0002507)4.58714347
26negative regulation of skeletal muscle tissue development (GO:0048642)4.54173765
27response to methylmercury (GO:0051597)4.53566001
28response to thyroid hormone (GO:0097066)4.52540453
29modulation by virus of host process (GO:0019054)4.51648573
30* myeloid cell development (GO:0061515)4.47257311
31regulation of superoxide anion generation (GO:0032928)4.44622530
32negative regulation of bone mineralization (GO:0030502)4.33311141
33negative regulation of phagocytosis (GO:0050765)4.28959406
34pattern specification involved in kidney development (GO:0061004)4.23579064
35* erythrocyte differentiation (GO:0030218)4.19948481
36thymic T cell selection (GO:0045061)4.19776120
37regulation of cholesterol homeostasis (GO:2000188)4.03004309
38positive regulation of protein deacetylation (GO:0090312)3.99547601
39positive thymic T cell selection (GO:0045059)3.93763167
40receptor catabolic process (GO:0032801)3.91248379
41regulation of histone H3-K27 methylation (GO:0061085)3.85379733
42germ cell migration (GO:0008354)3.85214608
43regulation of transcription regulatory region DNA binding (GO:2000677)3.83605609
44tetrapyrrole metabolic process (GO:0033013)3.74186514
45negative regulation of transcription regulatory region DNA binding (GO:2000678)3.70577310
46negative regulation of biomineral tissue development (GO:0070168)3.69539822
47regulation of extracellular matrix disassembly (GO:0010715)3.67560382
48cellular hyperosmotic response (GO:0071474)3.65733877
49positive regulation of transcription regulatory region DNA binding (GO:2000679)3.64936347
50modulation by symbiont of host cellular process (GO:0044068)3.64313470
51negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.63297237
52regulation of hydrogen peroxide metabolic process (GO:0010310)3.61667633
53regulation of histone deacetylation (GO:0031063)3.56713906
54hyaluronan catabolic process (GO:0030214)3.52738828
55purine-containing compound salvage (GO:0043101)3.52630137
56cellular response to virus (GO:0098586)3.51847793
57negative regulation of cAMP-mediated signaling (GO:0043951)3.51632763
58apoptotic process involved in morphogenesis (GO:0060561)3.49032742
59response to dexamethasone (GO:0071548)3.49017322
60positive regulation by organism of defense response of other organism involved in symbiotic interact3.48352559
61modulation by symbiont of host immune response (GO:0052553)3.48352559
62positive regulation by symbiont of host defense response (GO:0052509)3.48352559
63modulation by symbiont of host defense response (GO:0052031)3.48352559
64modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.48352559
65modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.48352559
66positive regulation of extracellular matrix organization (GO:1903055)3.48268074
67cellular response to dexamethasone stimulus (GO:0071549)3.46784457
68histone H4 deacetylation (GO:0070933)3.46606606
69GDP-mannose metabolic process (GO:0019673)3.44073314
70response to laminar fluid shear stress (GO:0034616)3.43972327
71positive regulation of CREB transcription factor activity (GO:0032793)3.39827922
72plasma lipoprotein particle assembly (GO:0034377)3.37135695
73regulation of exit from mitosis (GO:0007096)3.34858985
74oxygen transport (GO:0015671)3.32090016
75positive regulation of T cell apoptotic process (GO:0070234)3.31794155
76protein-lipid complex assembly (GO:0065005)3.29534924
77SMAD protein complex assembly (GO:0007183)3.28304131
78purine nucleotide salvage (GO:0032261)3.26928077
79response to lead ion (GO:0010288)3.26422854
80lysine catabolic process (GO:0006554)3.25604031
81lysine metabolic process (GO:0006553)3.25604031
82positive T cell selection (GO:0043368)3.24983445
83negative regulation of viral release from host cell (GO:1902187)3.24935739
84response to arsenic-containing substance (GO:0046685)3.24895731
85T cell selection (GO:0045058)3.23992360
86very-low-density lipoprotein particle assembly (GO:0034379)3.19458853
87negative regulation of DNA-templated transcription, elongation (GO:0032785)3.19053126
88histone H3-K9 modification (GO:0061647)3.17156755
89intracellular estrogen receptor signaling pathway (GO:0030520)3.16527840
90cysteine metabolic process (GO:0006534)3.15735184
91negative regulation of histone methylation (GO:0031061)3.11382379
92histone H3 deacetylation (GO:0070932)3.08481345
93histone H3-K4 trimethylation (GO:0080182)3.07487175
94modulation by virus of host morphology or physiology (GO:0019048)3.07334459
95regulation of response to osmotic stress (GO:0047484)3.05830576
96Peyers patch development (GO:0048541)3.05302676
97mucosal-associated lymphoid tissue development (GO:0048537)3.05302676
98RNA stabilization (GO:0043489)3.04686832
99mRNA stabilization (GO:0048255)3.04686832
100positive regulation of protein dephosphorylation (GO:0035307)3.04357774
101positive regulation of triglyceride biosynthetic process (GO:0010867)3.04037547
102negative regulation of cholesterol transport (GO:0032375)3.03715400
103negative regulation of sterol transport (GO:0032372)3.03715400
104activation of MAPKKK activity (GO:0000185)3.02789178
105hemoglobin metabolic process (GO:0020027)3.02722638
106ribosomal small subunit biogenesis (GO:0042274)3.01578565
107DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.00928723
108negative regulation of granulocyte differentiation (GO:0030853)2.99033026
109response to insecticide (GO:0017085)2.96717981
110negative regulation of calcium ion transport into cytosol (GO:0010523)2.96571467
111defense response to fungus (GO:0050832)2.96015108
112regulation of granulocyte differentiation (GO:0030852)2.92251979
113histone H3-K4 methylation (GO:0051568)2.86839478
114regulation of cholesterol biosynthetic process (GO:0045540)2.86288619
115positive regulation by host of viral transcription (GO:0043923)2.83579493
116protein insertion into membrane (GO:0051205)2.81493450
117positive regulation of protein kinase C signaling (GO:0090037)2.80984297
118regulation of cholesterol storage (GO:0010885)2.80901018
119platelet aggregation (GO:0070527)2.80586208
120heterochromatin organization (GO:0070828)2.80308265
121positive regulation of granulocyte differentiation (GO:0030854)2.79287973
122gas transport (GO:0015669)2.78858725
123regulation of superoxide metabolic process (GO:0090322)2.76436561
124peptidyl-lysine trimethylation (GO:0018023)2.76368502
125regulation of fatty acid beta-oxidation (GO:0031998)2.75575441
126protein carboxylation (GO:0018214)2.74934730
127peptidyl-glutamic acid carboxylation (GO:0017187)2.74934730
128osteoblast development (GO:0002076)2.73254129
129positive regulation of lymphocyte apoptotic process (GO:0070230)2.72815889
130activation of Rac GTPase activity (GO:0032863)2.72521460
131opioid receptor signaling pathway (GO:0038003)2.72114545
132regulation of chromatin binding (GO:0035561)2.71832237
133regulation of ARF GTPase activity (GO:0032312)2.71828518
134regulation of monocyte differentiation (GO:0045655)2.71391347
135dendritic cell differentiation (GO:0097028)2.70782738
136positive regulation of lipoprotein lipase activity (GO:0051006)2.70780505
137positive regulation of triglyceride lipase activity (GO:0061365)2.70780505
138regulation of histone H3-K9 methylation (GO:0051570)2.70600941
139sodium ion export (GO:0071436)2.69577149
140negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.68872055
141alpha-linolenic acid metabolic process (GO:0036109)2.68671292
142positive regulation of fatty acid beta-oxidation (GO:0032000)2.68387271
143regulation of translational termination (GO:0006449)2.67653342
144definitive hemopoiesis (GO:0060216)2.67191779
145positive regulation of triglyceride metabolic process (GO:0090208)2.66583868
146negative regulation of cell size (GO:0045792)2.65879512
147DNA damage response, signal transduction resulting in transcription (GO:0042772)2.65829548
148activation of JUN kinase activity (GO:0007257)2.64750235
149L-phenylalanine catabolic process (GO:0006559)2.64112498
150erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.64112498
151folic acid metabolic process (GO:0046655)2.63810263
152negative thymic T cell selection (GO:0045060)2.63644401
153regulation of RNA export from nucleus (GO:0046831)2.63637899
154positive regulation of protein homooligomerization (GO:0032464)2.63006089
155snRNA metabolic process (GO:0016073)2.62357022
156positive regulation of gene expression, epigenetic (GO:0045815)2.56145653
157response to muramyl dipeptide (GO:0032495)2.55988097
158regulation of protein deacetylation (GO:0090311)2.54931039
159viral transcription (GO:0019083)2.53918227
160apoptotic process involved in development (GO:1902742)2.52891424
161cellular response to interleukin-4 (GO:0071353)2.50346309
162histone H3-K9 methylation (GO:0051567)2.49959837
163negative regulation of fatty acid transport (GO:2000192)2.49952559
164regulation of triglyceride biosynthetic process (GO:0010866)2.49769602
165positive regulation of Rap GTPase activity (GO:0032854)2.48536751
166natural killer cell differentiation (GO:0001779)2.47240127
167retinoic acid receptor signaling pathway (GO:0048384)2.46068113
168regulation of type I interferon-mediated signaling pathway (GO:0060338)2.45120890
169mitotic G1/S transition checkpoint (GO:0044819)2.43618972
170proline biosynthetic process (GO:0006561)2.42955871
171histone H3 acetylation (GO:0043966)2.41728417
172segment specification (GO:0007379)2.41371886
173NIK/NF-kappaB signaling (GO:0038061)2.40286296
174negative T cell selection (GO:0043383)2.39521365
175regulation of translational fidelity (GO:0006450)2.39475923

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.06269121
2GATA1_22025678_ChIP-Seq_K562_Human3.96036062
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92635587
4* MYC_22102868_ChIP-Seq_BL_Human3.73531393
5* SCL_19346495_ChIP-Seq_HPC-7_Human3.56419590
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.56085469
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.25416442
8* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.07558278
9* GATA1_19941826_ChIP-Seq_K562_Human3.00101650
10* GATA1_19941827_ChIP-Seq_MEL_Mouse2.84932757
11VDR_21846776_ChIP-Seq_THP-1_Human2.82592557
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.81239671
13GATA1_22383799_ChIP-Seq_G1ME_Mouse2.49922951
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.45192987
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.40924362
16* TCF7_22412390_ChIP-Seq_EML_Mouse2.30154074
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26041700
18* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.23148424
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16555441
20* KDM2B_26808549_Chip-Seq_DND41_Human2.10981494
21KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.09498731
22* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.05135715
23* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.97189671
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.89804463
25* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88266360
26* MAF_26560356_Chip-Seq_TH1_Human1.86597006
27* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.86230269
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.85779172
29* GATA2_19941826_ChIP-Seq_K562_Human1.85243854
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83023252
31TET1_21451524_ChIP-Seq_MESCs_Mouse1.79385317
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.79136535
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77933152
34* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76796674
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74439133
36* UTX_26944678_Chip-Seq_JUKART_Human1.67853079
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66927162
38* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65948670
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.65043722
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63787548
41NCOR1_26117541_ChIP-Seq_K562_Human1.63061671
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62598338
43* LXR_22292898_ChIP-Seq_THP-1_Human1.61502920
44* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58487576
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.58270308
46CIITA_25753668_ChIP-Seq_RAJI_Human1.56584094
47VDR_24763502_ChIP-Seq_THP-1_Human1.56402811
48* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52771129
49SMC4_20622854_ChIP-Seq_HELA_Human1.51895361
50* RUNX1_22412390_ChIP-Seq_EML_Mouse1.48893573
51MAF_26560356_Chip-Seq_TH2_Human1.46357100
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.45443228
53ZNF263_19887448_ChIP-Seq_K562_Human1.45440880
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.44185303
55PHF8_20622854_ChIP-Seq_HELA_Human1.42426626
56* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41939304
57SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.41874121
58* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.41816990
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41480695
60* CTCF_27219007_Chip-Seq_Bcells_Human1.41004529
61* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38865075
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38529991
63* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38507937
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36971835
65* E2F1_20622854_ChIP-Seq_HELA_Human1.34199642
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33648150
67SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33103539
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32964033
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32273380
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31470291
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31403007
72* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30312844
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29665627
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29090824
75* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28658195
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.27944761
77RACK7_27058665_Chip-Seq_MCF-7_Human1.25715977
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.21317916
79* FOXP1_21924763_ChIP-Seq_HESCs_Human1.20818855
80* ELF1_20517297_ChIP-Seq_JURKAT_Human1.20404846
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20404208
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20002761
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19770495
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19214924
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.17771214
86TP53_22127205_ChIP-Seq_IMR90_Human1.17490763
87RUNX1_27514584_Chip-Seq_MCF-7_Human1.15533141
88* ATF3_27146783_Chip-Seq_COLON_Human1.14063367
89RARA_24833708_ChIP-Seq_LIVER_Mouse1.13556897
90EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13211339
91* MYB_26560356_Chip-Seq_TH1_Human1.13112035
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.13066163
93* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12340547
94RARB_24833708_ChIP-Seq_LIVER_Mouse1.12285850
95CTCF_26484167_Chip-Seq_Bcells_Mouse1.11194751
96* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11161016
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10856196
98KDM5A_27292631_Chip-Seq_BREAST_Human1.10823936
99* P68_20966046_ChIP-Seq_HELA_Human1.10343623
100* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09971461
101* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09652458
102PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08422373
103* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08328706
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07728374
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06237869
106* CREB1_26743006_Chip-Seq_LNCaP_Human1.05604440
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05334504
108SA1_27219007_Chip-Seq_Bcells_Human1.05225931
109* BCL6_27268052_Chip-Seq_Bcells_Human1.04846505
110CTCF_21964334_Chip-Seq_Bcells_Human1.04780082
111* BCOR_27268052_Chip-Seq_Bcells_Human1.04321813
112SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04178035
113* KDM2B_26808549_Chip-Seq_K562_Human1.04003087
114YY1_22570637_ChIP-Seq_MALME-3M_Human1.03802434
115IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03780792
116XRN2_22483619_ChIP-Seq_HELA_Human1.02874883
117ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02713948
118STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00808181
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99763757
120ETS1_21867929_ChIP-Seq_TH2_Mouse0.99562000
121FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99277654
122* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98465434
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98056869
124SPI1_20517297_ChIP-Seq_HL60_Human0.97857682
125* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96862661
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96545712
127ESR2_21235772_ChIP-Seq_MCF-7_Human0.96366887
128DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96019603
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96005161
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95969511
131* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93711909
132MYB_26560356_Chip-Seq_TH2_Human0.93590589
133STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92884141
134* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92457727
135P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92386568
136* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92173508
137CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90788245
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90619784
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90292858
140* GATA6_25053715_ChIP-Seq_YYC3_Human0.88606117
141* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88563585
142MYB_21317192_ChIP-Seq_ERMYB_Mouse0.87770532

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.98124646
2MP0004147_increased_porphyrin_level4.37361459
3MP0005083_abnormal_biliary_tract4.27009738
4MP0001545_abnormal_hematopoietic_system4.23814136
5MP0005397_hematopoietic_system_phenotyp4.23814136
6MP0002132_abnormal_respiratory_system4.09412876
7MP0003172_abnormal_lysosome_physiology3.50939081
8MP0005451_abnormal_body_composition3.50005423
9MP0003300_gastrointestinal_ulcer3.40321166
10MP0003705_abnormal_hypodermis_morpholog3.14377929
11MP0002139_abnormal_hepatobiliary_system3.00319098
12MP0005360_urolithiasis2.93446031
13MP0003436_decreased_susceptibility_to2.59915213
14MP0005058_abnormal_lysosome_morphology2.53935775
15MP0005377_hearing/vestibular/ear_phenot2.50573911
16MP0003878_abnormal_ear_physiology2.50573911
17MP0001873_stomach_inflammation2.47425770
18MP0003111_abnormal_nucleus_morphology2.47354113
19MP0009840_abnormal_foam_cell2.36605273
20MP0002249_abnormal_larynx_morphology2.34798839
21MP0003191_abnormal_cellular_cholesterol2.32316462
22MP0010352_gastrointestinal_tract_polyps2.31440087
23MP0005085_abnormal_gallbladder_physiolo2.24008891
24MP0004381_abnormal_hair_follicle2.22157160
25MP0003123_paternal_imprinting2.12391964
26MP0000465_gastrointestinal_hemorrhage2.09892552
27MP0009278_abnormal_bone_marrow2.02877106
28MP0002396_abnormal_hematopoietic_system2.01609643
29MP0005310_abnormal_salivary_gland1.99620899
30MP0005409_darkened_coat_color1.99180299
31MP0008260_abnormal_autophagy1.94989679
32MP0005365_abnormal_bile_salt1.87998158
33MP0005464_abnormal_platelet_physiology1.79380150
34MP0003866_abnormal_defecation1.73079484
35MP0000678_abnormal_parathyroid_gland1.66463245
36MP0001348_abnormal_lacrimal_gland1.63181901
37MP0008770_decreased_survivor_rate1.61116612
38MP0010329_abnormal_lipoprotein_level1.57775630
39MP0000685_abnormal_immune_system1.54599955
40MP0000609_abnormal_liver_physiology1.49146016
41MP0000015_abnormal_ear_pigmentation1.46116112
42MP0005636_abnormal_mineral_homeostasis1.46008957
43MP0010307_abnormal_tumor_latency1.44340301
44MP0008872_abnormal_physiological_respon1.43838921
45* MP0002398_abnormal_bone_marrow1.42165793
46MP0000490_abnormal_crypts_of1.37392705
47MP0002089_abnormal_postnatal_growth/wei1.36207092
48* MP0002722_abnormal_immune_system1.34270227
49MP0001849_ear_inflammation1.29802425
50MP0008875_abnormal_xenobiotic_pharmacok1.27847778
51MP0001986_abnormal_taste_sensitivity1.27538665
52MP0006054_spinal_hemorrhage1.26515090
53MP0004808_abnormal_hematopoietic_stem1.26233242
54MP0001502_abnormal_circadian_rhythm1.25682955
55* MP0000689_abnormal_spleen_morphology1.25628377
56MP0003879_abnormal_hair_cell1.24817984
57MP0003806_abnormal_nucleotide_metabolis1.22484477
58MP0000470_abnormal_stomach_morphology1.20168787
59MP0003252_abnormal_bile_duct1.18706628
60MP0001819_abnormal_immune_cell1.16075357
61MP0006082_CNS_inflammation1.14797963
62* MP0000598_abnormal_liver_morphology1.14306772
63MP0001666_abnormal_nutrient_absorption1.10487400
64MP0004130_abnormal_muscle_cell1.10284752
65* MP0009931_abnormal_skin_appearance1.07937328
66MP0001915_intracranial_hemorrhage1.06434210
67MP0004885_abnormal_endolymph1.05218733
68MP0000703_abnormal_thymus_morphology1.02890018
69MP0005025_abnormal_response_to1.02483524
70MP0004858_abnormal_nervous_system1.01629243
71* MP0002429_abnormal_blood_cell0.99853850
72MP0003303_peritoneal_inflammation0.99588281
73MP0009384_cardiac_valve_regurgitation0.99300330
74MP0003077_abnormal_cell_cycle0.97103162
75MP0009333_abnormal_splenocyte_physiolog0.96496001
76MP0003942_abnormal_urinary_system0.95686720
77MP0008775_abnormal_heart_ventricle0.95479769
78MP0001730_embryonic_growth_arrest0.95091626
79MP0009379_abnormal_foot_pigmentation0.94940591
80MP0005000_abnormal_immune_tolerance0.94828402
81MP0002452_abnormal_antigen_presenting0.94289558
82MP0000313_abnormal_cell_death0.93305727
83MP0010094_abnormal_chromosome_stability0.92458957
84MP0009672_abnormal_birth_weight0.91981555
85MP0003943_abnormal_hepatobiliary_system0.90045933
86MP0004185_abnormal_adipocyte_glucose0.88554718
87MP0000538_abnormal_urinary_bladder0.88465850
88MP0000566_synostosis0.88108496
89MP0002019_abnormal_tumor_incidence0.87447576
90MP0000003_abnormal_adipose_tissue0.87183282
91MP0003693_abnormal_embryo_hatching0.87179999
92MP0005319_abnormal_enzyme/_coenzyme0.86504501
93MP0005076_abnormal_cell_differentiation0.86369484
94* MP0002086_abnormal_extraembryonic_tissu0.85386312
95MP0003959_abnormal_lean_body0.85159556
96MP0001661_extended_life_span0.81437082
97MP0002970_abnormal_white_adipose0.81135130
98MP0002405_respiratory_system_inflammati0.80922134
99MP0003453_abnormal_keratinocyte_physiol0.80772638
100MP0001664_abnormal_digestion0.80251665
101MP0005174_abnormal_tail_pigmentation0.80006354
102MP0002138_abnormal_hepatobiliary_system0.79061012
103MP0004947_skin_inflammation0.78350310
104MP0001188_hyperpigmentation0.78346110
105MP0002653_abnormal_ependyma_morphology0.77238049
106MP0004264_abnormal_extraembryonic_tissu0.76868792
107MP0005501_abnormal_skin_physiology0.75325175
108MP0005381_digestive/alimentary_phenotyp0.74625851
109* MP0000716_abnormal_immune_system0.74193364
110MP0002118_abnormal_lipid_homeostasis0.74012130
111MP0000350_abnormal_cell_proliferation0.71759063
112MP0004957_abnormal_blastocyst_morpholog0.70910667
113MP0008961_abnormal_basal_metabolism0.70798617
114MP0006036_abnormal_mitochondrial_physio0.70758229
115MP0005387_immune_system_phenotype0.70587900
116MP0001790_abnormal_immune_system0.70587900
117* MP0002080_prenatal_lethality0.70274826
118MP0002932_abnormal_joint_morphology0.68843697
119MP0002933_joint_inflammation0.68489891
120MP0002877_abnormal_melanocyte_morpholog0.68467613
121MP0010155_abnormal_intestine_physiology0.66894957
122MP0000367_abnormal_coat/_hair0.65928150
123MP0003763_abnormal_thymus_physiology0.62571698
124MP0002419_abnormal_innate_immunity0.62563625
125* MP0000266_abnormal_heart_morphology0.61038986
126MP0009763_increased_sensitivity_to0.60994924
127MP0003115_abnormal_respiratory_system0.60570610
128MP0000858_altered_metastatic_potential0.60407939
129MP0005334_abnormal_fat_pad0.60317616
130MP0005375_adipose_tissue_phenotype0.60225570
131* MP0008469_abnormal_protein_level0.59321190
132MP0001800_abnormal_humoral_immune0.58640781
133MP0001663_abnormal_digestive_system0.58556792
134MP0004510_myositis0.58193918
135* MP0001697_abnormal_embryo_size0.57413736
136MP0003868_abnormal_feces_composition0.57355605
137MP0003329_amyloid_beta_deposits0.57325245
138MP0002088_abnormal_embryonic_growth/wei0.57160170
139MP0006292_abnormal_olfactory_placode0.56228527
140MP0003984_embryonic_growth_retardation0.55429090
141MP0003279_aneurysm0.55412277
142MP0005671_abnormal_response_to0.55339928
143MP0005166_decreased_susceptibility_to0.54445107
144MP0003566_abnormal_cell_adhesion0.53421635
145MP0000477_abnormal_intestine_morphology0.53341423
146MP0002420_abnormal_adaptive_immunity0.51521233
147MP0005666_abnormal_adipose_tissue0.50746153
148* MP0002723_abnormal_immune_serum0.50568425

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)9.41953914
2Reticulocytosis (HP:0001923)9.31933104
3Petechiae (HP:0000967)7.45059292
4Polycythemia (HP:0001901)6.95288127
5Abnormality of reticulocytes (HP:0004312)6.17475329
6Short middle phalanx of the 5th finger (HP:0004220)6.08661110
7Prolonged bleeding time (HP:0003010)5.20165191
8Impaired platelet aggregation (HP:0003540)4.67944855
9Abnormal platelet function (HP:0011869)4.67944855
10Hyperbilirubinemia (HP:0002904)4.61311065
11Abnormal number of erythroid precursors (HP:0012131)4.42881961
12Obstructive sleep apnea (HP:0002870)4.33003343
13Abnormality of cells of the erythroid lineage (HP:0012130)3.92810021
14Increased density of long bones (HP:0006392)3.89740021
15Cholelithiasis (HP:0001081)3.89667273
16Broad palm (HP:0001169)3.65785433
17Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.61537306
18Short 5th finger (HP:0009237)3.60499381
19Brushfield spots (HP:0001088)3.57597592
20Epistaxis (HP:0000421)3.54080421
21Abnormal gallbladder morphology (HP:0012437)3.51354636
22Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.28493210
23Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.23042512
24Thin bony cortex (HP:0002753)3.16404187
25Increased serum ferritin (HP:0003281)3.11023049
26Abnormal gallbladder physiology (HP:0012438)3.05698411
27Cholecystitis (HP:0001082)3.05698411
28Diaphragmatic weakness (HP:0009113)3.01007149
29Deep venous thrombosis (HP:0002625)3.00670275
30Abnormal hemoglobin (HP:0011902)2.91992144
31Broad face (HP:0000283)2.89881523
32Deep palmar crease (HP:0006191)2.88861465
33Hypochromic anemia (HP:0001931)2.82576363
34Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.80659072
35Slender build (HP:0001533)2.79403652
36Seborrheic dermatitis (HP:0001051)2.77522973
37Hyperthyroidism (HP:0000836)2.77412786
38Abnormality of iron homeostasis (HP:0011031)2.76052988
39Rectal prolapse (HP:0002035)2.69518449
40Protruding tongue (HP:0010808)2.68995717
41Hypertensive crisis (HP:0100735)2.68963479
42Abnormality of the thoracic spine (HP:0100711)2.64200362
43Insomnia (HP:0100785)2.64079180
44Abnormality of transition element cation homeostasis (HP:0011030)2.60263177
45Pallor (HP:0000980)2.60016452
46Truncus arteriosus (HP:0001660)2.55213962
47Diplopia (HP:0000651)2.55192138
48Abnormality of binocular vision (HP:0011514)2.55192138
49Facial hemangioma (HP:0000329)2.54478400
50Ulnar bowing (HP:0003031)2.54187879
51Abnormality of the phalanges of the 5th finger (HP:0004213)2.53440551
52Hypoparathyroidism (HP:0000829)2.48861419
53Abnormality of the aortic arch (HP:0012303)2.47078549
54Xanthomatosis (HP:0000991)2.46828664
55Annular pancreas (HP:0001734)2.46448488
56Abnormality of the gallbladder (HP:0005264)2.46176805
57Rib fusion (HP:0000902)2.42675858
58Cutaneous photosensitivity (HP:0000992)2.42175175
59Hypochromic microcytic anemia (HP:0004840)2.40247553
60Long palpebral fissure (HP:0000637)2.40247254
61Abnormal platelet volume (HP:0011876)2.38966877
62Paralysis (HP:0003470)2.38355937
63Gastrointestinal infarctions (HP:0005244)2.37146243
64Self-mutilation (HP:0000742)2.28739066
65Thoracic kyphosis (HP:0002942)2.28103153
66Hypercortisolism (HP:0001578)2.23212203
67Decreased subcutaneous fat (HP:0001002)2.23089387
68Microcytic anemia (HP:0001935)2.21999873
69Complete atrioventricular canal defect (HP:0001674)2.20809246
70Hypoplastic iliac wings (HP:0002866)2.20512242
71J-shaped sella turcica (HP:0002680)2.17694544
72Stridor (HP:0010307)2.16348355
73Papilloma (HP:0012740)2.14107231
74Verrucae (HP:0200043)2.14107231
75Squamous cell carcinoma (HP:0002860)2.13263759
76Chronic obstructive pulmonary disease (HP:0006510)2.11245531
77Obstructive lung disease (HP:0006536)2.11245531
78Cervical subluxation (HP:0003308)2.10368824
79Purpura (HP:0000979)2.08519580
80Macrocytic anemia (HP:0001972)2.07754613
81Abnormality of dental color (HP:0011073)2.07253259
82Increased mean platelet volume (HP:0011877)2.06902130
83Myopathic facies (HP:0002058)2.05815176
84Ileus (HP:0002595)2.04298701
85Agammaglobulinemia (HP:0004432)2.02792191
86Panhypogammaglobulinemia (HP:0003139)2.01601655
87Pustule (HP:0200039)2.01234443
88Emphysema (HP:0002097)2.00261727
89Abnormality of the heme biosynthetic pathway (HP:0010472)11.3647788
90Acanthocytosis (HP:0001927)10.2203546
91Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99684166
92Thin ribs (HP:0000883)1.99387368
93Bowel incontinence (HP:0002607)1.98556250
94Supernumerary ribs (HP:0005815)1.96658512
95Intrahepatic cholestasis (HP:0001406)1.96297365
96Generalized hyperpigmentation (HP:0007440)1.96180525
97Joint stiffness (HP:0001387)1.96057277
98Hypercholesterolemia (HP:0003124)1.95738352
99Abnormality of subcutaneous fat tissue (HP:0001001)1.95688400
100Disproportionate tall stature (HP:0001519)1.94584334
101Pointed chin (HP:0000307)1.93560287
102Intestinal fistula (HP:0100819)1.92982460
103Spinal canal stenosis (HP:0003416)1.87858809
104Abnormality of monocarboxylic acid metabolism (HP:0010996)1.87321292
105Colitis (HP:0002583)1.85898982
106Nasal polyposis (HP:0100582)1.85675046
107Broad distal phalanx of finger (HP:0009836)1.85297515
108Lymphangioma (HP:0100764)1.84709857
109Abnormality of the columella (HP:0009929)1.84064358
110Biconcave vertebral bodies (HP:0004586)1.84025234
111Abnormality of the fingertips (HP:0001211)1.82911007
112Eczematoid dermatitis (HP:0000976)1.82600602
113Testicular atrophy (HP:0000029)1.81530022
114Menorrhagia (HP:0000132)1.81224334
115Dislocated radial head (HP:0003083)1.81151671
116Abnormal large intestine physiology (HP:0012700)1.79629567
117Breast hypoplasia (HP:0003187)1.79244484
118Vaginal fistula (HP:0004320)1.78334863
119Supernumerary bones of the axial skeleton (HP:0009144)1.78056141
120Supernumerary nipples (HP:0002558)1.77182429
121Abnormality of the radial head (HP:0003995)1.76986675
122Gingival bleeding (HP:0000225)1.75569136
123Abnormality of the nasal mucosa (HP:0000433)1.74893885
124Short middle phalanx of finger (HP:0005819)1.72688024
125Abnormality of homocysteine metabolism (HP:0010919)1.71973144
126Homocystinuria (HP:0002156)1.71973144
127Gastrointestinal dysmotility (HP:0002579)1.71267748
128Gastrointestinal stroma tumor (HP:0100723)1.71021673
129Abnormality of polysaccharide metabolism (HP:0011012)1.70762517
130Abnormality of glycosaminoglycan metabolism (HP:0004371)1.70762517
131Abnormality of mucopolysaccharide metabolism (HP:0011020)1.70762517
132Hypobetalipoproteinemia (HP:0003563)1.70467868
133Atelectasis (HP:0100750)1.70413485
134Hyperlipoproteinemia (HP:0010980)1.70141199
135Global brain atrophy (HP:0002283)1.67021401
136Osteomalacia (HP:0002749)1.65531465
137Joint hemorrhage (HP:0005261)1.64794187
138Cellulitis (HP:0100658)1.63921879
139Hypertriglyceridemia (HP:0002155)1.60285123
140Urticaria (HP:0001025)1.58733526
141Back pain (HP:0003418)1.57892169
142Abnormality of the Achilles tendon (HP:0005109)1.57885489
143Gastrointestinal inflammation (HP:0004386)1.57221256
144Easy fatigability (HP:0003388)1.56536745
145Multiple lipomas (HP:0001012)1.56474085
146Autoimmune thrombocytopenia (HP:0001973)1.52732632
147Abnormal delayed hypersensitivity skin test (HP:0002963)1.51900222
148Basal cell carcinoma (HP:0002671)1.51128190
149Atrioventricular canal defect (HP:0006695)1.49763219
150Hepatocellular carcinoma (HP:0001402)1.44287872
151Thickened nuchal skin fold (HP:0000474)1.43615840
152Abnormality of the common coagulation pathway (HP:0010990)1.42419430
153Duodenal stenosis (HP:0100867)1.42355518
154Small intestinal stenosis (HP:0012848)1.42355518
155Hemorrhage of the eye (HP:0011885)1.42009705
156Achilles tendon contracture (HP:0001771)1.41953666
157Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.41570263
158Hyperacusis (HP:0010780)1.41552443
159Hypolipoproteinemia (HP:0010981)1.40502365
160Myocardial infarction (HP:0001658)1.40107580
161Prolonged partial thromboplastin time (HP:0003645)1.39412376
162Acrocyanosis (HP:0001063)1.38999967
163Spontaneous hematomas (HP:0007420)1.38934097
164Hypoalphalipoproteinemia (HP:0003233)1.38650872

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K106.13918105
2TRIB34.07604627
3PKN23.68228822
4PRPF4B3.59748401
5EEF2K3.54510895
6SMG13.16962686
7MAP4K12.99820626
8ICK2.47867939
9STK42.20591342
10ERN12.19347459
11GRK62.06508075
12IRAK31.91769589
13TAOK11.90734479
14MAP3K111.85138109
15MAPK111.84395214
16CDC71.77743653
17TNK21.76283937
18STK101.75920136
19SIK11.75860623
20CDK121.75032932
21NEK21.73881821
22CDK191.72052956
23TAOK31.64194373
24BMX1.61260673
25SIK21.58161831
26TAOK21.55171575
27CDK41.51159526
28KDR1.36749874
29IRAK21.34327070
30MAPK151.32340989
31DYRK31.29668533
32LRRK21.29634355
33MAP3K81.27122815
34ALK1.26926737
35PTK61.26704742
36RIPK41.20413393
37CDK61.18963655
38SCYL21.18381353
39EIF2AK11.16754576
40DYRK1B1.15065720
41IRAK41.14209964
42NME21.08002846
43BCKDK1.03970240
44RPS6KA21.03767618
45PIM11.03581370
46CDC42BPA0.99072379
47BLK0.97807390
48TYRO30.95626851
49MAP2K20.94717025
50BRSK10.94393385
51MTOR0.92815395
52AKT20.92390881
53PRKD30.92379838
54MKNK20.91922629
55RPS6KA10.88589196
56UHMK10.85924272
57MAP3K70.84566998
58RPS6KL10.84148915
59RPS6KC10.84148915
60JAK20.83983198
61RPS6KA60.83276882
62SIK30.81139008
63BUB10.80065333
64FLT30.77830694
65RPS6KB20.75919983
66TYK20.74729675
67EPHA20.70707113
68AURKA0.65933351
69RPS6KA40.65551140
70MAP3K30.65330338
71PAK40.63972024
72TBK10.63381914
73IKBKB0.62307920
74HIPK20.62166598
75RET0.61471870
76IKBKE0.61384781
77SYK0.60608910
78ZAP700.60020291
79MARK30.59862911
80TLK10.58729235
81PAK20.57979393
82CAMKK10.57623358
83MAPK120.56465386
84STK30.55420051
85MAP3K10.54397144
86STK160.54264651
87WNK40.53668443
88CHEK20.52800638
89MAP3K130.52047254
90SGK30.51808461
91PRKD20.51624579
92CHUK0.51251636
93PRKCH0.50871472
94CDK20.48752385
95FES0.48175469
96CLK10.48077737
97BTK0.48071981
98CDK90.47678355
99WNK10.46880327
100CHEK10.46632958
101MAPKAPK20.46210518
102TAF10.45962848
103PDPK10.45074947
104AKT10.44381264
105MAPK30.44129657
106MAP2K30.44127045
107STK110.44047899
108RPS6KA50.43213021
109PRKAA20.43132677
110HCK0.43084102
111MAPK40.42479806
112MAPK10.42431850
113FGFR40.40858051
114MELK0.40161963
115JAK30.40110180
116MARK20.39996919
117CDK70.39319158
118ATM0.38316271
119TTN0.37758224
120MAP2K10.37098272
121ITK0.36398799
122PRKG20.36199735
123PRKCI0.34012810
124PDK10.33795583
125CDK80.33392055
126NME10.32981923
127CAMK1D0.32860953
128DAPK30.32619560
129MAPK80.32113495
130PIM20.31808378
131DAPK20.31607954
132* CDK10.31530730
133BRAF0.30638276
134PRKAA10.30494421
135MUSK0.29474176
136CSK0.28886049
137PRKD10.28473642
138MST1R0.28448412
139PDK20.28116966

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008604.66641594
2Sulfur relay system_Homo sapiens_hsa041222.98381283
3Lysine degradation_Homo sapiens_hsa003102.94684173
4Nitrogen metabolism_Homo sapiens_hsa009102.63868586
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.55106995
6Notch signaling pathway_Homo sapiens_hsa043302.55103588
7Systemic lupus erythematosus_Homo sapiens_hsa053222.49459530
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.45020055
9Other glycan degradation_Homo sapiens_hsa005112.33163347
10Chronic myeloid leukemia_Homo sapiens_hsa052202.23267210
11ABC transporters_Homo sapiens_hsa020102.06282042
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.04744901
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.04608524
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.98789974
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85081681
16Arginine biosynthesis_Homo sapiens_hsa002201.84915527
17Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.84803821
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.76632472
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.76533000
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.76199607
21Pentose phosphate pathway_Homo sapiens_hsa000301.69865081
22Non-small cell lung cancer_Homo sapiens_hsa052231.68004170
23Bladder cancer_Homo sapiens_hsa052191.62010130
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.61543990
25Vitamin B6 metabolism_Homo sapiens_hsa007501.59064948
26Bile secretion_Homo sapiens_hsa049761.58089429
27T cell receptor signaling pathway_Homo sapiens_hsa046601.55804088
28DNA replication_Homo sapiens_hsa030301.49003554
29Acute myeloid leukemia_Homo sapiens_hsa052211.48544042
30Endometrial cancer_Homo sapiens_hsa052131.46872002
31One carbon pool by folate_Homo sapiens_hsa006701.34029834
32Selenocompound metabolism_Homo sapiens_hsa004501.32287917
33Biosynthesis of amino acids_Homo sapiens_hsa012301.32218212
34PPAR signaling pathway_Homo sapiens_hsa033201.30385383
35Complement and coagulation cascades_Homo sapiens_hsa046101.26934166
36Pancreatic cancer_Homo sapiens_hsa052121.25729445
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.25410101
38Fat digestion and absorption_Homo sapiens_hsa049751.23888693
39Tryptophan metabolism_Homo sapiens_hsa003801.22488123
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.20746095
41Fatty acid degradation_Homo sapiens_hsa000711.20032327
42Cell cycle_Homo sapiens_hsa041101.19579791
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13751113
44ErbB signaling pathway_Homo sapiens_hsa040121.13392889
45mRNA surveillance pathway_Homo sapiens_hsa030151.09508947
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.09406283
47Hepatitis C_Homo sapiens_hsa051601.06547788
48Choline metabolism in cancer_Homo sapiens_hsa052311.05329001
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04860827
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03836053
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.01807242
52Insulin resistance_Homo sapiens_hsa049311.00721795
53MAPK signaling pathway_Homo sapiens_hsa040101.00460035
54Inositol phosphate metabolism_Homo sapiens_hsa005621.00089980
55Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00011353
56B cell receptor signaling pathway_Homo sapiens_hsa046620.99780090
57Spliceosome_Homo sapiens_hsa030400.96436519
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.95966296
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.95814911
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94847343
61Colorectal cancer_Homo sapiens_hsa052100.93366006
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93172245
63AMPK signaling pathway_Homo sapiens_hsa041520.92650476
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91828787
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.91095916
66Carbon metabolism_Homo sapiens_hsa012000.90646204
67Prolactin signaling pathway_Homo sapiens_hsa049170.90618255
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89728859
69Alcoholism_Homo sapiens_hsa050340.89581254
70TNF signaling pathway_Homo sapiens_hsa046680.89110608
71Prostate cancer_Homo sapiens_hsa052150.87610384
72Herpes simplex infection_Homo sapiens_hsa051680.85788012
73Small cell lung cancer_Homo sapiens_hsa052220.85201316
74Prion diseases_Homo sapiens_hsa050200.84576245
75Hepatitis B_Homo sapiens_hsa051610.83657329
76Renal cell carcinoma_Homo sapiens_hsa052110.81802337
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.81424004
78Ribosome_Homo sapiens_hsa030100.81367872
79Caffeine metabolism_Homo sapiens_hsa002320.79423773
80Epstein-Barr virus infection_Homo sapiens_hsa051690.78788998
81Pyruvate metabolism_Homo sapiens_hsa006200.78774233
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78488684
83Folate biosynthesis_Homo sapiens_hsa007900.78330650
84Base excision repair_Homo sapiens_hsa034100.77592184
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76468506
86GnRH signaling pathway_Homo sapiens_hsa049120.75189291
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71221158
88Apoptosis_Homo sapiens_hsa042100.71119060
89Platelet activation_Homo sapiens_hsa046110.70849807
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70063388
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70005810
92Viral carcinogenesis_Homo sapiens_hsa052030.69182243
93Type II diabetes mellitus_Homo sapiens_hsa049300.68729066
94Primary immunodeficiency_Homo sapiens_hsa053400.68242563
95Glioma_Homo sapiens_hsa052140.67931572
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.67415119
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65727367
98Influenza A_Homo sapiens_hsa051640.65573511
99HTLV-I infection_Homo sapiens_hsa051660.64847474
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.63870649
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63396384
102beta-Alanine metabolism_Homo sapiens_hsa004100.60528431
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58067746
104Staphylococcus aureus infection_Homo sapiens_hsa051500.57907837
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57898911
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56515462
107Estrogen signaling pathway_Homo sapiens_hsa049150.56237904
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56089987
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56045010
110Hematopoietic cell lineage_Homo sapiens_hsa046400.55937232
111Malaria_Homo sapiens_hsa051440.54621369
112FoxO signaling pathway_Homo sapiens_hsa040680.54508194
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54026662
114Leishmaniasis_Homo sapiens_hsa051400.53985321
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53926514
116Chemokine signaling pathway_Homo sapiens_hsa040620.52529734
117p53 signaling pathway_Homo sapiens_hsa041150.52449759
118Fatty acid metabolism_Homo sapiens_hsa012120.52140506
119Cholinergic synapse_Homo sapiens_hsa047250.51693161
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.50369077
121Peroxisome_Homo sapiens_hsa041460.50162295
122Vitamin digestion and absorption_Homo sapiens_hsa049770.50132297
123Measles_Homo sapiens_hsa051620.50063563
124Insulin signaling pathway_Homo sapiens_hsa049100.48201169
125Osteoclast differentiation_Homo sapiens_hsa043800.47982301
126Tuberculosis_Homo sapiens_hsa051520.45837921
127Endocytosis_Homo sapiens_hsa041440.45737054
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45560235
129Melanoma_Homo sapiens_hsa052180.45265077
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44360910
131Basal cell carcinoma_Homo sapiens_hsa052170.43275506
132mTOR signaling pathway_Homo sapiens_hsa041500.42705061
133Starch and sucrose metabolism_Homo sapiens_hsa005000.42464361
134Phenylalanine metabolism_Homo sapiens_hsa003600.42176176
135Galactose metabolism_Homo sapiens_hsa000520.41860634
136Sulfur metabolism_Homo sapiens_hsa009200.41722092
137Thyroid cancer_Homo sapiens_hsa052160.41702898
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41110353
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40985711
140MicroRNAs in cancer_Homo sapiens_hsa052060.40984208
141Toxoplasmosis_Homo sapiens_hsa051450.40075487
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40072997
143Fructose and mannose metabolism_Homo sapiens_hsa000510.39854842
144Histidine metabolism_Homo sapiens_hsa003400.39596803
145VEGF signaling pathway_Homo sapiens_hsa043700.38795376
146HIF-1 signaling pathway_Homo sapiens_hsa040660.38791194
147Jak-STAT signaling pathway_Homo sapiens_hsa046300.37393007
148Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34488336
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34463345
150Glycerolipid metabolism_Homo sapiens_hsa005610.33528410

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