ZFPM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.90991013
2vocalization behavior (GO:0071625)4.80580727
3cerebellar granule cell differentiation (GO:0021707)4.45539649
4neuron cell-cell adhesion (GO:0007158)4.35944102
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.33240634
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.29951205
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.26362765
8cell communication by electrical coupling (GO:0010644)4.24629128
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.23872963
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.17533117
11positive regulation of synapse maturation (GO:0090129)4.11953175
12regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.03199076
13regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.94688282
14regulation of glutamate receptor signaling pathway (GO:1900449)3.93706094
15glutamate receptor signaling pathway (GO:0007215)3.91495469
16exploration behavior (GO:0035640)3.91173342
17cardiac myofibril assembly (GO:0055003)3.87669294
18synaptic vesicle maturation (GO:0016188)3.76223843
19protein localization to synapse (GO:0035418)3.72576379
20retinal cone cell development (GO:0046549)3.70840137
21synaptic transmission, glutamatergic (GO:0035249)3.58670410
22axonal fasciculation (GO:0007413)3.58281085
23synaptic vesicle exocytosis (GO:0016079)3.57983073
24cerebellar Purkinje cell differentiation (GO:0021702)3.56116579
25neurotransmitter-gated ion channel clustering (GO:0072578)3.55492843
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.54632746
27dendrite morphogenesis (GO:0048813)3.53720641
28regulation of synapse structural plasticity (GO:0051823)3.51322350
29neuron recognition (GO:0008038)3.49918488
30positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.48285261
31positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.47880884
32postsynaptic membrane organization (GO:0001941)3.47146250
33regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.44545417
34sodium ion export (GO:0071436)3.38009232
35dendritic spine morphogenesis (GO:0060997)3.34572166
36G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.34411775
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.33944152
38regulation of synaptic vesicle exocytosis (GO:2000300)3.33360250
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30767664
40layer formation in cerebral cortex (GO:0021819)3.29372972
41negative regulation of cytosolic calcium ion concentration (GO:0051481)3.29091505
42synaptic vesicle docking involved in exocytosis (GO:0016081)3.27943299
43establishment of nucleus localization (GO:0040023)3.27651754
44plasma membrane repair (GO:0001778)3.23389765
45cellular potassium ion homeostasis (GO:0030007)3.22039134
46regulation of synapse maturation (GO:0090128)3.20733058
47regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.20149157
48presynaptic membrane assembly (GO:0097105)3.17491275
49cell communication involved in cardiac conduction (GO:0086065)3.17098426
50glutamate secretion (GO:0014047)3.16054846
51cell differentiation in hindbrain (GO:0021533)3.13344986
52negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.12460288
53innervation (GO:0060384)3.11045100
54interkinetic nuclear migration (GO:0022027)3.10101401
55neuron-neuron synaptic transmission (GO:0007270)3.09694597
56actin-myosin filament sliding (GO:0033275)3.09628276
57muscle filament sliding (GO:0030049)3.09628276
58glycine transport (GO:0015816)3.06569588
59regulation of dendritic spine morphogenesis (GO:0061001)3.04912081
60sarcoplasmic reticulum calcium ion transport (GO:0070296)3.04898519
61cardiac muscle hypertrophy (GO:0003300)3.03255148
62neuronal action potential propagation (GO:0019227)3.01889589
63gamma-aminobutyric acid signaling pathway (GO:0007214)2.98850119
64long-term memory (GO:0007616)2.98037183
65regulation of excitatory postsynaptic membrane potential (GO:0060079)2.97647931
66positive regulation of synapse assembly (GO:0051965)2.97032696
67regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.95600374
68regulation of cell communication by electrical coupling (GO:0010649)2.95052059
69central nervous system projection neuron axonogenesis (GO:0021952)2.94927534
70regulation of actin filament-based movement (GO:1903115)2.94896228
71positive regulation of potassium ion transmembrane transport (GO:1901381)2.94839593
72presynaptic membrane organization (GO:0097090)2.94644287
73regulation of relaxation of muscle (GO:1901077)2.94370437
74cell migration in hindbrain (GO:0021535)2.94004348
75regulation of synaptic vesicle transport (GO:1902803)2.93378848
76negative regulation of potassium ion transmembrane transport (GO:1901380)2.93101563
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90574913
78regulation of neuronal synaptic plasticity (GO:0048168)2.90227951
79regulation of skeletal muscle contraction (GO:0014819)2.89998710
80regulation of membrane repolarization (GO:0060306)2.87492671
81neurotransmitter secretion (GO:0007269)2.87365748
82myofibril assembly (GO:0030239)2.87247780
83striated muscle hypertrophy (GO:0014897)2.86327278
84regulation of long-term neuronal synaptic plasticity (GO:0048169)2.85783636
85positive regulation of fibroblast migration (GO:0010763)2.84995019
86dermatan sulfate biosynthetic process (GO:0030208)2.84529368
87regulation of synaptic transmission, glutamatergic (GO:0051966)2.84468441
88response to pheromone (GO:0019236)2.84217639
89axon extension (GO:0048675)2.82441777
90regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.81432138
91L-amino acid import (GO:0043092)2.80636987
92negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78341709
93regulation of postsynaptic membrane potential (GO:0060078)2.77842428
94proline transport (GO:0015824)2.75903614
95long-term synaptic potentiation (GO:0060291)2.75418903
96actin-mediated cell contraction (GO:0070252)2.74636379
97cardiac muscle contraction (GO:0060048)2.73703690
98central nervous system neuron axonogenesis (GO:0021955)2.73115586
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.72934656
100regulation of sarcomere organization (GO:0060297)2.72736585
101membrane depolarization during action potential (GO:0086010)2.72321675
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.71360235
103transmission of nerve impulse (GO:0019226)2.71212332
104cochlea development (GO:0090102)2.70898993
105gamma-aminobutyric acid transport (GO:0015812)2.70781738
106positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.69346471
107relaxation of cardiac muscle (GO:0055119)2.68404417
108positive regulation of membrane potential (GO:0045838)2.67690403
109regulation of axon extension involved in axon guidance (GO:0048841)2.67097360
110startle response (GO:0001964)2.63879172
111synapse organization (GO:0050808)2.63383303
112positive regulation of axon extension (GO:0045773)2.63126985
113cardiac chamber formation (GO:0003207)2.62947495
114regulation of synapse organization (GO:0050807)2.62925996
115regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62916865
116cerebellar Purkinje cell layer development (GO:0021680)2.62649993
117regulation of potassium ion transmembrane transporter activity (GO:1901016)2.62315132
118regulation of meiosis I (GO:0060631)2.62135256
119regulation of dendritic spine development (GO:0060998)2.60465599
120dermatan sulfate metabolic process (GO:0030205)2.58588035
121regulation of synaptic plasticity (GO:0048167)2.58163204
122activation of protein kinase A activity (GO:0034199)2.57952464
123labyrinthine layer development (GO:0060711)2.55659189
124muscle hypertrophy in response to stress (GO:0003299)2.53595622
125cardiac muscle adaptation (GO:0014887)2.53595622
126cardiac muscle hypertrophy in response to stress (GO:0014898)2.53595622
127regulation of cardiac muscle cell contraction (GO:0086004)2.51223824
128positive regulation of meiosis (GO:0045836)2.49291223
129nucleus localization (GO:0051647)2.46970719
130cardiac ventricle formation (GO:0003211)2.46300367
131sarcomere organization (GO:0045214)2.44498332
132negative regulation of hormone biosynthetic process (GO:0032353)2.42987265
133piRNA metabolic process (GO:0034587)2.42931928
134muscle hypertrophy (GO:0014896)2.42774595
135regulation of striated muscle contraction (GO:0006942)2.41841056
136regulation of female receptivity (GO:0045924)2.41655536
137striated muscle contraction (GO:0006941)2.41608812
138regulation of DNA methylation (GO:0044030)2.40975565
139positive regulation of cardiac muscle cell differentiation (GO:2000727)2.39164407
140inner ear receptor stereocilium organization (GO:0060122)2.38650090
141regulation of sodium ion transmembrane transport (GO:1902305)2.38566399
142cerebral cortex radially oriented cell migration (GO:0021799)2.38413227
143lymphangiogenesis (GO:0001946)2.32140678
144regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.29345850
145phosphorelay signal transduction system (GO:0000160)2.28921542
146relaxation of muscle (GO:0090075)2.27489841
147regulation of sodium ion transmembrane transporter activity (GO:2000649)2.26567438
148positive regulation of meiotic cell cycle (GO:0051446)2.24709096
149neuromuscular synaptic transmission (GO:0007274)2.24131357
150regulation of cardiac muscle contraction (GO:0055117)2.23024852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.63546563
2GBX2_23144817_ChIP-Seq_PC3_Human3.39573257
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12435574
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89250624
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83613805
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78498609
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78498609
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57162003
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55316686
10* EED_16625203_ChIP-ChIP_MESCs_Mouse2.55252781
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.54195189
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51171138
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49373922
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38612949
15RNF2_27304074_Chip-Seq_ESCs_Mouse2.20030755
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19397184
17AR_21572438_ChIP-Seq_LNCaP_Human2.18794650
18DROSHA_22980978_ChIP-Seq_HELA_Human2.16135515
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.12848821
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99484994
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.96932486
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92932185
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91429692
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.88752862
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88302293
26ZNF274_21170338_ChIP-Seq_K562_Hela1.83387867
27REST_21632747_ChIP-Seq_MESCs_Mouse1.82942913
28IGF1R_20145208_ChIP-Seq_DFB_Human1.81314783
29* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80403978
30* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.69416839
31SMAD4_21799915_ChIP-Seq_A2780_Human1.67456365
32* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66717184
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.66612837
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.63168589
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59279097
36* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57083726
37* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56766684
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56550446
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52447032
40* CBX2_27304074_Chip-Seq_ESCs_Mouse1.51094368
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47633638
42TP53_16413492_ChIP-PET_HCT116_Human1.47298622
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47156030
44* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46572070
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.45556545
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.44428397
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44106535
48EWS_26573619_Chip-Seq_HEK293_Human1.40927130
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40820547
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40769535
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40156383
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37952350
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37952350
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36725344
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.36190181
56P300_19829295_ChIP-Seq_ESCs_Human1.35627631
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35298292
58* RING1B_27294783_Chip-Seq_ESCs_Mouse1.33904182
59* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33594294
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32063814
61* RNF2_27304074_Chip-Seq_NSC_Mouse1.30476654
62* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30140149
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29743717
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29103144
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28675623
66* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28041229
67* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27914727
68* SMAD3_21741376_ChIP-Seq_EPCs_Human1.27866131
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26563699
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25063161
71CBP_20019798_ChIP-Seq_JUKART_Human1.23913212
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23913212
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23800079
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22665274
75* AR_19668381_ChIP-Seq_PC3_Human1.22004415
76* RING1B_27294783_Chip-Seq_NPCs_Mouse1.19934162
77AHR_22903824_ChIP-Seq_MCF-7_Human1.19785559
78AR_25329375_ChIP-Seq_VCAP_Human1.19064529
79* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18594692
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17806559
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.17535643
82* STAT3_23295773_ChIP-Seq_U87_Human1.14752468
83TP53_18474530_ChIP-ChIP_U2OS_Human1.14723381
84* KDM2B_26808549_Chip-Seq_REH_Human1.14659943
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14278658
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14217144
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13995014
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.12416678
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11865799
90* SMAD4_21741376_ChIP-Seq_EPCs_Human1.11306743
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10782778
92TAF15_26573619_Chip-Seq_HEK293_Human1.09923514
93BCAT_22108803_ChIP-Seq_LS180_Human1.09869563
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.09612324
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.09177138
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.08727844
97FUS_26573619_Chip-Seq_HEK293_Human1.06710049
98VDR_22108803_ChIP-Seq_LS180_Human1.06700800
99* TP53_20018659_ChIP-ChIP_R1E_Mouse1.05972194
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.04822511
101* FLI1_21867929_ChIP-Seq_TH2_Mouse1.03470795
102SOX9_26525672_Chip-Seq_HEART_Mouse1.03291287
103* TCF4_23295773_ChIP-Seq_U87_Human1.02833930
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01596480
105* SMAD4_21741376_ChIP-Seq_HESCs_Human1.00924026
106* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00499556
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98949633
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98903606
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.97100729
110* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96345120
111RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95545543
112* RUNX2_22187159_ChIP-Seq_PCA_Human0.93953151
113* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93082255
114* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93082255
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92931023
116* PRDM14_20953172_ChIP-Seq_ESCs_Human0.92289680
117* ER_23166858_ChIP-Seq_MCF-7_Human0.91361862
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89785680
119KDM2B_26808549_Chip-Seq_K562_Human0.89457216
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89181707
121ESR1_20079471_ChIP-ChIP_T-47D_Human0.88549180
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88111339
123ISL1_27105846_Chip-Seq_CPCs_Mouse0.87909132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.84183950
2MP0003880_abnormal_central_pattern3.34984479
3MP0003635_abnormal_synaptic_transmissio3.14539677
4MP0002837_dystrophic_cardiac_calcinosis2.90214806
5MP0000751_myopathy2.73414992
6MP0008438_abnormal_cutaneous_collagen2.62713870
7MP0009046_muscle_twitch2.44719126
8MP0002063_abnormal_learning/memory/cond2.39916974
9* MP0004215_abnormal_myocardial_fiber2.35430067
10MP0009745_abnormal_behavioral_response2.34944483
11MP0004270_analgesia2.24499397
12MP0002064_seizures2.16063330
13MP0004145_abnormal_muscle_electrophysio2.06362899
14MP0004084_abnormal_cardiac_muscle2.04238441
15MP0002572_abnormal_emotion/affect_behav2.03040424
16MP0001968_abnormal_touch/_nociception2.02147980
17MP0005503_abnormal_tendon_morphology1.89653709
18MP0000778_abnormal_nervous_system1.88151540
19MP0005623_abnormal_meninges_morphology1.85697987
20MP0002272_abnormal_nervous_system1.84241003
21MP0002736_abnormal_nociception_after1.82117822
22MP0001440_abnormal_grooming_behavior1.81399053
23MP0002184_abnormal_innervation1.77592656
24MP0003950_abnormal_plasma_membrane1.75633301
25MP0002734_abnormal_mechanical_nocicepti1.75369701
26MP0001486_abnormal_startle_reflex1.75059655
27MP0003137_abnormal_impulse_conducting1.73714843
28MP0003718_maternal_effect1.68776264
29MP0002067_abnormal_sensory_capabilities1.65842296
30MP0008569_lethality_at_weaning1.63709133
31MP0004858_abnormal_nervous_system1.63676150
32MP0003890_abnormal_embryonic-extraembry1.60929607
33MP0002735_abnormal_chemical_nociception1.58845713
34MP0004484_altered_response_of1.56394212
35MP0005423_abnormal_somatic_nervous1.54300899
36MP0003122_maternal_imprinting1.53836296
37MP0009780_abnormal_chondrocyte_physiolo1.53830225
38MP0005551_abnormal_eye_electrophysiolog1.52850548
39MP0002127_abnormal_cardiovascular_syste1.49622591
40* MP0004085_abnormal_heartbeat1.49285416
41MP0005275_abnormal_skin_tensile1.48086921
42MP0003646_muscle_fatigue1.48047140
43MP0008877_abnormal_DNA_methylation1.46878656
44MP0003879_abnormal_hair_cell1.46516786
45MP0000749_muscle_degeneration1.45672105
46MP0002638_abnormal_pupillary_reflex1.45574438
47MP0001958_emphysema1.40483591
48MP0004036_abnormal_muscle_relaxation1.40300811
49MP0002972_abnormal_cardiac_muscle1.36863665
50MP0005330_cardiomyopathy1.35854269
51MP0005620_abnormal_muscle_contractility1.29862996
52MP0001501_abnormal_sleep_pattern1.29699610
53MP0004233_abnormal_muscle_weight1.27432110
54MP0003329_amyloid_beta_deposits1.25500709
55MP0002733_abnormal_thermal_nociception1.25417091
56MP0002557_abnormal_social/conspecific_i1.25010117
57MP0000569_abnormal_digit_pigmentation1.24563330
58MP0004087_abnormal_muscle_fiber1.21259966
59MP0004811_abnormal_neuron_physiology1.20819272
60* MP0006138_congestive_heart_failure1.18725872
61MP0000955_abnormal_spinal_cord1.18608422
62MP0001970_abnormal_pain_threshold1.16157844
63MP0010368_abnormal_lymphatic_system1.16120023
64MP0002882_abnormal_neuron_morphology1.12729118
65MP0004924_abnormal_behavior1.12023693
66MP0005386_behavior/neurological_phenoty1.12023693
67MP0001984_abnormal_olfaction1.10873587
68MP0001299_abnormal_eye_distance/1.10785694
69MP0008775_abnormal_heart_ventricle1.09703980
70MP0005253_abnormal_eye_physiology1.08627271
71MP0006292_abnormal_olfactory_placode1.08490568
72MP0002066_abnormal_motor_capabilities/c1.07460461
73MP0002106_abnormal_muscle_physiology1.04799215
74MP0005369_muscle_phenotype1.03135802
75MP0002108_abnormal_muscle_morphology1.01453830
76MP0002152_abnormal_brain_morphology1.01109930
77MP0003279_aneurysm1.01099997
78MP0005171_absent_coat_pigmentation0.99556657
79MP0001502_abnormal_circadian_rhythm0.99547803
80MP0002234_abnormal_pharynx_morphology0.98886668
81MP0004272_abnormal_basement_membrane0.97568039
82MP0001986_abnormal_taste_sensitivity0.96480938
83MP0003385_abnormal_body_wall0.94310686
84* MP0001544_abnormal_cardiovascular_syste0.94186064
85* MP0005385_cardiovascular_system_phenoty0.94186064
86MP0004742_abnormal_vestibular_system0.93424522
87MP0003119_abnormal_digestive_system0.93092841
88MP0006276_abnormal_autonomic_nervous0.92381333
89MP0002295_abnormal_pulmonary_circulatio0.91659804
90MP0001188_hyperpigmentation0.90741658
91MP0004043_abnormal_pH_regulation0.90185921
92MP0000534_abnormal_ureter_morphology0.89682144
93* MP0000759_abnormal_skeletal_muscle0.89073656
94MP0000537_abnormal_urethra_morphology0.89049097
95MP0001661_extended_life_span0.88839999
96MP0005167_abnormal_blood-brain_barrier0.87363299
97MP0004885_abnormal_endolymph0.87264435
98MP0010630_abnormal_cardiac_muscle0.87187990
99MP0002089_abnormal_postnatal_growth/wei0.86468076
100MP0005395_other_phenotype0.86128462
101MP0000747_muscle_weakness0.84920178
102MP0000631_abnormal_neuroendocrine_gland0.84481565
103MP0003045_fibrosis0.84326977
104MP0003633_abnormal_nervous_system0.83734973
105MP0005187_abnormal_penis_morphology0.83649763
106MP0009384_cardiac_valve_regurgitation0.83209070
107MP0005595_abnormal_vascular_smooth0.83156037
108MP0001177_atelectasis0.81499255
109MP0003632_abnormal_nervous_system0.80221123
110MP0004510_myositis0.80049068
111MP0006072_abnormal_retinal_apoptosis0.79100770
112MP0002102_abnormal_ear_morphology0.78687818
113MP0001963_abnormal_hearing_physiology0.78333165
114* MP0003115_abnormal_respiratory_system0.76703157
115MP0000750_abnormal_muscle_regeneration0.76414771
116MP0004142_abnormal_muscle_tone0.76138672
117MP0004130_abnormal_muscle_cell0.75759938
118MP0009250_abnormal_appendicular_skeleto0.75364211
119MP0003861_abnormal_nervous_system0.74094613
120MP0003634_abnormal_glial_cell0.73431734
121MP0002269_muscular_atrophy0.72881942
122MP0005646_abnormal_pituitary_gland0.72780422
123MP0001879_abnormal_lymphatic_vessel0.72657299
124MP0000013_abnormal_adipose_tissue0.71455441
125MP0003935_abnormal_craniofacial_develop0.71062588
126MP0008057_abnormal_DNA_replication0.71012030

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.62112865
2Myokymia (HP:0002411)4.11847261
3Progressive cerebellar ataxia (HP:0002073)3.93085026
4Focal seizures (HP:0007359)3.90954116
5Action tremor (HP:0002345)3.72214846
6Sudden death (HP:0001699)3.70138566
7Muscle fiber inclusion bodies (HP:0100299)3.68836514
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.58094186
9Type 1 muscle fiber predominance (HP:0003803)3.47998683
10Atrial fibrillation (HP:0005110)3.46392718
11Nemaline bodies (HP:0003798)3.42321084
12Visual hallucinations (HP:0002367)3.35630475
13Primary atrial arrhythmia (HP:0001692)3.32320482
14Broad metatarsal (HP:0001783)3.24613062
15Epileptic encephalopathy (HP:0200134)3.23822576
16Atonic seizures (HP:0010819)3.17378293
17Supraventricular tachycardia (HP:0004755)3.11871953
18Abnormality of the lower motor neuron (HP:0002366)3.10399243
19Protrusio acetabuli (HP:0003179)3.10012580
20Supraventricular arrhythmia (HP:0005115)3.08896260
21Febrile seizures (HP:0002373)3.06653273
22Shallow orbits (HP:0000586)2.98858305
23Dysmetric saccades (HP:0000641)2.92799752
24Abnormality of the calf musculature (HP:0001430)2.87907822
25Syncope (HP:0001279)2.87647325
26Absence seizures (HP:0002121)2.84810101
27Prolonged QT interval (HP:0001657)2.81349950
28Fair hair (HP:0002286)2.78508108
29Hip contracture (HP:0003273)2.71004350
30Gaze-evoked nystagmus (HP:0000640)2.65441468
31Premature rupture of membranes (HP:0001788)2.64165345
32Dysdiadochokinesis (HP:0002075)2.58311787
33Myotonia (HP:0002486)2.57670980
34Calf muscle hypertrophy (HP:0008981)2.52741336
35Broad-based gait (HP:0002136)2.51606018
36Generalized tonic-clonic seizures (HP:0002069)2.50122458
37Genetic anticipation (HP:0003743)2.49021518
38Bundle branch block (HP:0011710)2.47485778
39Ventricular fibrillation (HP:0001663)2.45693260
40Dialeptic seizures (HP:0011146)2.44969072
41Poor eye contact (HP:0000817)2.44137185
42Limited hip movement (HP:0008800)2.36865833
43Ventricular arrhythmia (HP:0004308)2.36101216
44Congenital stationary night blindness (HP:0007642)2.33379756
45Muscle hypertrophy of the lower extremities (HP:0008968)2.33023245
46Drooling (HP:0002307)2.31470306
47Excessive salivation (HP:0003781)2.31470306
48Abnormal EKG (HP:0003115)2.30191287
49Hemiplegia (HP:0002301)2.25174629
50Abnormality of the ischium (HP:0003174)2.23986277
51Abnormality of abdominal situs (HP:0011620)2.23909560
52Abdominal situs inversus (HP:0003363)2.23909560
53Exercise-induced myalgia (HP:0003738)2.23819194
54Distal arthrogryposis (HP:0005684)2.23315845
55Overgrowth (HP:0001548)2.22784098
56Hyperventilation (HP:0002883)2.22780650
57Bladder diverticulum (HP:0000015)2.22592928
58Impaired social interactions (HP:0000735)2.22258523
59Abnormal social behavior (HP:0012433)2.22258523
60Increased variability in muscle fiber diameter (HP:0003557)2.20090953
61Ventricular tachycardia (HP:0004756)2.16059280
62Truncal ataxia (HP:0002078)2.15778643
63Abnormality of the labia minora (HP:0012880)2.13465877
64Impaired vibration sensation in the lower limbs (HP:0002166)2.10745377
65Subaortic stenosis (HP:0001682)2.09988764
66Abnormality of the left ventricular outflow tract (HP:0011103)2.09988764
67Postural instability (HP:0002172)2.09351021
68Lipoatrophy (HP:0100578)2.09206651
69Protruding tongue (HP:0010808)2.08821066
70Obstructive sleep apnea (HP:0002870)2.06408178
71Abnormal atrioventricular conduction (HP:0005150)2.05273939
72Dysmetria (HP:0001310)2.03597174
73Hypoventilation (HP:0002791)2.02004134
74Right ventricular cardiomyopathy (HP:0011663)2.00617571
75Type II lissencephaly (HP:0007260)2.00336242
76Mildly elevated creatine phosphokinase (HP:0008180)2.00281844
77Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.96602110
78Scanning speech (HP:0002168)1.95020326
79Hemiparesis (HP:0001269)1.93117662
80Depression (HP:0000716)1.91998445
81Generalized hypopigmentation of hair (HP:0011358)1.91711097
82Fetal akinesia sequence (HP:0001989)1.90929144
83Narrow nasal bridge (HP:0000446)1.90434512
84Aplasia/Hypoplasia of the tibia (HP:0005772)1.88928460
85Difficulty climbing stairs (HP:0003551)1.88915116
86Anxiety (HP:0000739)1.88760152
87Vascular tortuosity (HP:0004948)1.88395407
88Amblyopia (HP:0000646)1.86828005
89Anterior segment dysgenesis (HP:0007700)1.86792068
90Absent phalangeal crease (HP:0006109)1.85819044
91Hypoplastic ischia (HP:0003175)1.85498647
92Aortic aneurysm (HP:0004942)1.84934609
93Ankle contracture (HP:0006466)1.84788115
94Impaired smooth pursuit (HP:0007772)1.83521170
95Bradycardia (HP:0001662)1.81947000
96Ankle clonus (HP:0011448)1.80083224
97EMG: myopathic abnormalities (HP:0003458)1.80028500
98Left ventricular hypertrophy (HP:0001712)1.79904094
99Cerebral aneurysm (HP:0004944)1.79825702
100Lower limb asymmetry (HP:0100559)1.79112897
101Aortic dissection (HP:0002647)1.78506396
102Papillary thyroid carcinoma (HP:0002895)1.78230944
103Hypoplastic left heart (HP:0004383)1.78041611
104Absent speech (HP:0001344)1.76017628
105Epileptiform EEG discharges (HP:0011182)1.75864758
106Lymphangioma (HP:0100764)1.75041975
107Lower limb amyotrophy (HP:0007210)1.74436087
108Exercise-induced muscle cramps (HP:0003710)1.73964367
109Pancreatic cysts (HP:0001737)1.73423754
110Buphthalmos (HP:0000557)1.73300353
111Abnormality of ocular smooth pursuit (HP:0000617)1.72959123
112True hermaphroditism (HP:0010459)1.72468977
113Abnormality of dentin (HP:0010299)1.72439236
114Increased corneal curvature (HP:0100692)1.72371333
115Keratoconus (HP:0000563)1.72371333
116Pointed chin (HP:0000307)1.72324739
117Abnormal finger flexion creases (HP:0006143)1.71948571
118EMG: neuropathic changes (HP:0003445)1.71254986
119Termporal pattern (HP:0011008)1.71085123
120Insidious onset (HP:0003587)1.71085123
121Supernumerary spleens (HP:0009799)1.70978403
122Broad ribs (HP:0000885)1.70363683
123Abnormal eating behavior (HP:0100738)1.70180951
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.69506890
125Hyperkalemia (HP:0002153)1.69423369
126Abnormality of skeletal muscle fiber size (HP:0012084)1.68359483
127EEG with generalized epileptiform discharges (HP:0011198)1.65581712
128Urinary bladder sphincter dysfunction (HP:0002839)1.64921372
129Retinal dysplasia (HP:0007973)1.64628694
130Muscle fiber splitting (HP:0003555)1.64424334
131Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.63379670
132Rapidly progressive (HP:0003678)1.61889478
133Hyporeflexia of lower limbs (HP:0002600)1.61640531
134Central scotoma (HP:0000603)1.61232139
135Heart block (HP:0012722)1.60872280
136Round ear (HP:0100830)1.60293325
137Hyperextensible skin (HP:0000974)1.60230336
138Torticollis (HP:0000473)1.59860408
139Exotropia (HP:0000577)1.59751242
140Abnormality of midbrain morphology (HP:0002418)1.59362831
141Molar tooth sign on MRI (HP:0002419)1.59362831
142Neck muscle weakness (HP:0000467)1.57603505
143Limb dystonia (HP:0002451)1.57407647
144Frequent falls (HP:0002359)1.56683650
145Pheochromocytoma (HP:0002666)1.55929493
146Difficulty running (HP:0009046)1.54361500
147Areflexia of lower limbs (HP:0002522)1.53612389
148Wrist flexion contracture (HP:0001239)1.53255925
149Clumsiness (HP:0002312)1.51822723
150Proximal amyotrophy (HP:0007126)1.51677877
151Muscular dystrophy (HP:0003560)1.51013101
152Optic nerve hypoplasia (HP:0000609)1.50074311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.51098904
2EPHA43.27254502
3FRK3.23260447
4TIE13.13639046
5MARK12.79964919
6MAP3K42.61194882
7PINK12.29377158
8BMPR1B2.10971900
9MAP3K92.06687205
10PAK62.04167591
11MAP2K71.97078045
12ERBB31.95488570
13MINK11.93891502
14NTRK21.93435649
15PHKG21.86472397
16PHKG11.86472397
17CAMKK11.86203815
18KSR11.73284986
19RIPK11.71426303
20CASK1.67103405
21PTK2B1.63958885
22GRK11.59077595
23LMTK21.57527096
24PLK21.56636558
25PDGFRA1.54296873
26PAK31.53066758
27PRKD31.51117078
28MAPK131.50394807
29LATS11.45985461
30TNIK1.45394563
31MAP2K41.45013333
32STK381.43885120
33TTN1.43871371
34WNK31.43344758
35KSR21.40195212
36PRPF4B1.33330569
37PKN11.29850596
38LATS21.27159648
39ADRBK21.25737874
40TGFBR11.22876689
41DMPK1.21548941
42WNK11.20514755
43ACVR1B1.19745368
44CAMKK21.19744590
45MAP3K131.17097685
46SIK21.11221017
47CAMK2A1.08147141
48FER1.06580942
49TRIM281.06253658
50CDK51.04619362
51DDR21.04312143
52PDK31.04166878
53PDK41.04166878
54UHMK11.02657810
55EPHB21.02623277
56MAP3K71.00843657
57CDC42BPA0.99999382
58MYLK0.99566787
59PRKCG0.97868229
60TAOK10.97603341
61PNCK0.96281653
62CAMK2D0.96145901
63CAMK2B0.95206796
64CCNB10.94412120
65RAF10.94305450
66CAMK10.93983227
67CAMK1G0.93367750
68STK240.90886853
69PIK3CA0.90128837
70DAPK20.87761926
71MAP3K120.87541073
72CDK180.86347980
73CDK150.85887015
74CAMK40.85382518
75NUAK10.85002900
76PRKCH0.83648587
77PIK3CG0.83544909
78ROCK20.78498381
79CDK140.78280638
80MAPKAPK30.78104724
81PKN20.76716961
82MOS0.76251382
83NTRK10.75887564
84ROCK10.73101270
85ILK0.71678471
86ADRBK10.71452478
87INSRR0.71324567
88AKT30.71059904
89TRIB30.70888924
90STK38L0.70885048
91CDK11A0.70725385
92PRKG10.69430505
93MAP2K10.69198681
94NEK60.68521140
95TRPM70.68071400
96MAP4K20.67658480
97RET0.66757544
98MET0.66736007
99GRK50.65482247
100LIMK10.64673308
101MARK20.64450977
102TYRO30.63779470
103SGK4940.62889469
104SGK2230.62889469
105PDGFRB0.61481644
106OBSCN0.61009323
107PRKAA10.60607562
108PRKCE0.60386639
109DYRK1A0.58970487
110OXSR10.58810534
111NEK10.58379076
112PRKAA20.57796053
113CSNK1G20.54485768
114WNK40.54235362
115STK110.53877657
116PLK40.53570789
117SGK10.53024223
118SGK30.52925822
119MAPK120.52504388
120STK30.52366412
121CAMK2G0.52052881
122CDK190.51727030
123SGK20.51509932
124MUSK0.50163288
125MELK0.49737237
126CSNK1D0.49652560
127PRKACA0.48236076
128RPS6KA30.47576533
129PRKACB0.47341670
130ICK0.47288641
131MAPK100.47119958
132ARAF0.47112265
133STK390.46890228
134PTK20.46878716
135BRAF0.46596325
136FES0.45507838
137PRKCZ0.45275891
138PAK20.44020813
139PDK20.43661813
140MAP3K60.43442196
141TAOK30.43349803
142MKNK20.42624697
143ALK0.41487387
144PRKD10.41137558
145NLK0.39220949
146BRSK20.38862604

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.44631426
2Circadian entrainment_Homo sapiens_hsa047132.48576115
3Long-term potentiation_Homo sapiens_hsa047202.42232698
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35750651
5Glutamatergic synapse_Homo sapiens_hsa047242.29116574
6Dilated cardiomyopathy_Homo sapiens_hsa054142.17756748
7Phototransduction_Homo sapiens_hsa047442.12876173
8Synaptic vesicle cycle_Homo sapiens_hsa047212.08321492
9GABAergic synapse_Homo sapiens_hsa047272.07614275
10Morphine addiction_Homo sapiens_hsa050321.98576481
11Cardiac muscle contraction_Homo sapiens_hsa042601.96436127
12Amphetamine addiction_Homo sapiens_hsa050311.95061044
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.93424415
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86350563
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.83730268
16Olfactory transduction_Homo sapiens_hsa047401.81170837
17Salivary secretion_Homo sapiens_hsa049701.78837471
18Long-term depression_Homo sapiens_hsa047301.76074834
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72232225
20Dopaminergic synapse_Homo sapiens_hsa047281.70601010
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68871850
22Oxytocin signaling pathway_Homo sapiens_hsa049211.65954963
23Gastric acid secretion_Homo sapiens_hsa049711.63965842
24Cholinergic synapse_Homo sapiens_hsa047251.58748914
25Insulin secretion_Homo sapiens_hsa049111.58695241
26Taste transduction_Homo sapiens_hsa047421.55046386
27Calcium signaling pathway_Homo sapiens_hsa040201.54122999
28Axon guidance_Homo sapiens_hsa043601.51895547
29Gap junction_Homo sapiens_hsa045401.51367655
30Renin secretion_Homo sapiens_hsa049241.42031734
31GnRH signaling pathway_Homo sapiens_hsa049121.41168120
32cAMP signaling pathway_Homo sapiens_hsa040241.36646221
33Serotonergic synapse_Homo sapiens_hsa047261.36366220
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33145316
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.31290315
36Type II diabetes mellitus_Homo sapiens_hsa049301.20749371
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20052539
38Estrogen signaling pathway_Homo sapiens_hsa049151.18750962
39Glioma_Homo sapiens_hsa052141.18169435
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12831758
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12804431
42Cocaine addiction_Homo sapiens_hsa050301.11434429
43Melanogenesis_Homo sapiens_hsa049161.11269466
44Dorso-ventral axis formation_Homo sapiens_hsa043201.11177003
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09325837
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06212700
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.99497081
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96778186
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95216981
50ErbB signaling pathway_Homo sapiens_hsa040120.94611137
51Butanoate metabolism_Homo sapiens_hsa006500.93189620
52Focal adhesion_Homo sapiens_hsa045100.92609920
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85481652
54Propanoate metabolism_Homo sapiens_hsa006400.84460205
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83906710
56ABC transporters_Homo sapiens_hsa020100.83848063
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81812502
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.81361252
59Protein digestion and absorption_Homo sapiens_hsa049740.78874162
60Thyroid hormone synthesis_Homo sapiens_hsa049180.77799751
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77306654
62ECM-receptor interaction_Homo sapiens_hsa045120.77007487
63Oocyte meiosis_Homo sapiens_hsa041140.74924232
64Glucagon signaling pathway_Homo sapiens_hsa049220.73657574
65Basal transcription factors_Homo sapiens_hsa030220.71969374
66Choline metabolism in cancer_Homo sapiens_hsa052310.71627332
67Wnt signaling pathway_Homo sapiens_hsa043100.70013484
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69903586
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69840219
70MAPK signaling pathway_Homo sapiens_hsa040100.68052943
71Renal cell carcinoma_Homo sapiens_hsa052110.67626501
72Rap1 signaling pathway_Homo sapiens_hsa040150.67302013
73Alzheimers disease_Homo sapiens_hsa050100.67043373
74Nitrogen metabolism_Homo sapiens_hsa009100.66433828
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66331462
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66171846
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66127066
78Pancreatic secretion_Homo sapiens_hsa049720.65969629
79Endometrial cancer_Homo sapiens_hsa052130.65401990
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65349162
81Proteoglycans in cancer_Homo sapiens_hsa052050.63303370
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62688893
83Tight junction_Homo sapiens_hsa045300.60305199
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59881785
85Hippo signaling pathway_Homo sapiens_hsa043900.59647138
86Hedgehog signaling pathway_Homo sapiens_hsa043400.59286089
87Bile secretion_Homo sapiens_hsa049760.58915301
88Collecting duct acid secretion_Homo sapiens_hsa049660.58753997
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.56122185
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55454332
91Arginine and proline metabolism_Homo sapiens_hsa003300.55071131
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54342951
93Amoebiasis_Homo sapiens_hsa051460.53942366
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.53789085
95Ras signaling pathway_Homo sapiens_hsa040140.53375282
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53292268
97Ether lipid metabolism_Homo sapiens_hsa005650.53199666
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52874338
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52692099
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52305336
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52087948
102Adherens junction_Homo sapiens_hsa045200.50892397
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50391686
104Ovarian steroidogenesis_Homo sapiens_hsa049130.50299203
105Viral myocarditis_Homo sapiens_hsa054160.50158158
106Melanoma_Homo sapiens_hsa052180.50051794
107Fatty acid biosynthesis_Homo sapiens_hsa000610.49424347
108Colorectal cancer_Homo sapiens_hsa052100.49171672
109VEGF signaling pathway_Homo sapiens_hsa043700.49029128
110Insulin signaling pathway_Homo sapiens_hsa049100.48709770
111AMPK signaling pathway_Homo sapiens_hsa041520.48657514
112Fanconi anemia pathway_Homo sapiens_hsa034600.46672120
113Circadian rhythm_Homo sapiens_hsa047100.45424188
114Linoleic acid metabolism_Homo sapiens_hsa005910.44390740
115Vibrio cholerae infection_Homo sapiens_hsa051100.43105558
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42961921
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42955444
118mTOR signaling pathway_Homo sapiens_hsa041500.42458287
119TGF-beta signaling pathway_Homo sapiens_hsa043500.41950409
120Basal cell carcinoma_Homo sapiens_hsa052170.41329989
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40459163
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40425934
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39591235

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