ZFR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an RNA-binding protein characterized by its DZF (domain associated with zinc fingers) domain. The encoded protein may play a role in the nucleocytoplasmic shuttling of another RNA-binding protein, Staufen homolog 2, in neurons. Expression of this gene is regulated through alternative polyadenylation that mediates differential microRNA targeting. Elevated expression of this gene has been observed in human patients with pancreatic cancer and knockdown of this gene may result in reduced viability and invasion of pancreatic cancer cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.63417283
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.59902268
3nuclear pore organization (GO:0006999)5.38426067
4synaptic vesicle exocytosis (GO:0016079)5.14222474
5locomotory exploration behavior (GO:0035641)5.12385144
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.08404798
7vocalization behavior (GO:0071625)5.07474797
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.02160087
9synaptic vesicle maturation (GO:0016188)4.96453950
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.84496763
11regulation of synaptic vesicle exocytosis (GO:2000300)4.84102210
12glutamate secretion (GO:0014047)4.82803366
13neuron cell-cell adhesion (GO:0007158)4.82037853
14protein localization to synapse (GO:0035418)4.78020950
15mitotic sister chromatid cohesion (GO:0007064)4.63672715
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.57785950
17regulation of glutamate receptor signaling pathway (GO:1900449)4.55935604
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.46217952
19regulation of synaptic vesicle transport (GO:1902803)4.25532334
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.23096797
21exploration behavior (GO:0035640)4.20414072
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.14351354
23pore complex assembly (GO:0046931)4.13438699
24glutamate receptor signaling pathway (GO:0007215)4.11091755
25neuronal action potential propagation (GO:0019227)4.10296396
26synaptic transmission, glutamatergic (GO:0035249)3.99071905
27regulation of neuronal synaptic plasticity (GO:0048168)3.97981487
28neurotransmitter secretion (GO:0007269)3.97146356
29layer formation in cerebral cortex (GO:0021819)3.92244038
30neuron recognition (GO:0008038)3.91578964
31neuron-neuron synaptic transmission (GO:0007270)3.89849855
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.67063486
33axonal fasciculation (GO:0007413)3.66962860
34presynaptic membrane assembly (GO:0097105)3.66386993
35neurotransmitter-gated ion channel clustering (GO:0072578)3.65557813
36dendritic spine morphogenesis (GO:0060997)3.63224691
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59905456
38sister chromatid segregation (GO:0000819)3.58084238
39long-term memory (GO:0007616)3.56611039
40long-term synaptic potentiation (GO:0060291)3.54555959
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.48577823
42proline transport (GO:0015824)3.47772009
43regulation of postsynaptic membrane potential (GO:0060078)3.46801379
44mitotic sister chromatid segregation (GO:0000070)3.45507009
45postsynaptic membrane organization (GO:0001941)3.44972555
46synaptic vesicle endocytosis (GO:0048488)3.42566526
47regulation of dendritic spine morphogenesis (GO:0061001)3.41230399
48positive regulation of membrane potential (GO:0045838)3.39383357
49regulation of synapse structural plasticity (GO:0051823)3.39072090
50presynaptic membrane organization (GO:0097090)3.37079419
51double-strand break repair via nonhomologous end joining (GO:0006303)3.37047897
52non-recombinational repair (GO:0000726)3.37047897
53regulation of synaptic plasticity (GO:0048167)3.36220902
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35261701
55gamma-aminobutyric acid transport (GO:0015812)3.31256933
56regulation of mitotic spindle organization (GO:0060236)3.31232341
57regulation of centriole replication (GO:0046599)3.30400901
58transmission of nerve impulse (GO:0019226)3.29700821
59regulation of DNA endoreduplication (GO:0032875)3.27434612
60regulation of neurotransmitter secretion (GO:0046928)3.26975638
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26785216
62regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.26458805
63neurotransmitter transport (GO:0006836)3.25455262
64positive regulation of synapse maturation (GO:0090129)3.23266432
65establishment of integrated proviral latency (GO:0075713)3.22979223
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.20300833
67activation of protein kinase A activity (GO:0034199)3.20113418
68DNA unwinding involved in DNA replication (GO:0006268)3.17917058
69innervation (GO:0060384)3.17250449
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16566063
71cerebellar Purkinje cell differentiation (GO:0021702)3.16194838
72regulation of vesicle fusion (GO:0031338)3.15229049
73protein localization to kinetochore (GO:0034501)3.14924768
74metaphase plate congression (GO:0051310)3.11201090
75vesicle transport along microtubule (GO:0047496)3.09868576
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09600325
77positive regulation of synaptic transmission, GABAergic (GO:0032230)3.07789478
78ribosome assembly (GO:0042255)3.07258329
79response to histamine (GO:0034776)3.05815129
80mitotic metaphase plate congression (GO:0007080)3.04112103
81positive regulation of neurotransmitter secretion (GO:0001956)3.03462346
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.01869861
83cellular potassium ion homeostasis (GO:0030007)3.01269110
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00626996
85regulation of sister chromatid cohesion (GO:0007063)2.98547249
86detection of calcium ion (GO:0005513)2.98499775
87regulation of neurotransmitter transport (GO:0051588)2.98197886
88histone H2A acetylation (GO:0043968)2.97472295
89mitotic nuclear envelope disassembly (GO:0007077)2.97324594
90behavioral fear response (GO:0001662)2.97071074
91behavioral defense response (GO:0002209)2.97071074
92synapse assembly (GO:0007416)2.96842278
93kinetochore organization (GO:0051383)2.96257966
94regulation of spindle organization (GO:0090224)2.95566030
95startle response (GO:0001964)2.95182452
96positive regulation of mitotic sister chromatid separation (GO:1901970)2.95178919
97positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.95178919
98positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.95178919
99mitotic chromosome condensation (GO:0007076)2.94398299
100dendrite morphogenesis (GO:0048813)2.92617731
101regulation of dendritic spine development (GO:0060998)2.92142189
102sister chromatid cohesion (GO:0007062)2.91977216
103learning (GO:0007612)2.91468091
104regulation of neurotransmitter levels (GO:0001505)2.91349314
105negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.90488109
106neuromuscular process controlling balance (GO:0050885)2.89010614
107nuclear envelope disassembly (GO:0051081)2.88856623
108membrane disassembly (GO:0030397)2.88856623
109cerebellar granule cell differentiation (GO:0021707)2.88835401
110fear response (GO:0042596)2.88659481
111spindle checkpoint (GO:0031577)2.87523142
112positive regulation of dendritic spine morphogenesis (GO:0061003)2.85873127
113positive regulation of neurotransmitter transport (GO:0051590)2.85609832
114dendritic spine organization (GO:0097061)2.85524945
115membrane depolarization (GO:0051899)2.84895313
116regulation of female receptivity (GO:0045924)2.84721387
117auditory behavior (GO:0031223)2.82278390
118protein localization to chromosome, centromeric region (GO:0071459)2.81606960
119organelle transport along microtubule (GO:0072384)2.81521968
120positive regulation of synaptic transmission (GO:0050806)2.80864002
121regulation of synaptic transmission, GABAergic (GO:0032228)2.80849181
122membrane hyperpolarization (GO:0060081)2.80603553
123regulation of RNA export from nucleus (GO:0046831)2.80573345
124synaptic transmission (GO:0007268)2.78902286
125regulation of synaptic transmission (GO:0050804)2.78456875
126mitotic spindle checkpoint (GO:0071174)2.78234156
127synapse organization (GO:0050808)2.78101774
128G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.76533224
129regulation of sister chromatid segregation (GO:0033045)2.75816968
130regulation of mitotic sister chromatid separation (GO:0010965)2.75816968
131regulation of mitotic sister chromatid segregation (GO:0033047)2.75816968
132regulation of chromosome segregation (GO:0051983)2.73935892
133cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.73226987
134positive regulation of synapse assembly (GO:0051965)2.72957453
135regulation of centrosome duplication (GO:0010824)2.72360900
136regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.72054061
137regulation of mitotic metaphase/anaphase transition (GO:0030071)2.72054061
138central nervous system projection neuron axonogenesis (GO:0021952)2.71767170
139social behavior (GO:0035176)2.71694692
140intraspecies interaction between organisms (GO:0051703)2.71694692
141establishment of chromosome localization (GO:0051303)2.71082914
142positive regulation of chromosome segregation (GO:0051984)2.70530720
143synapsis (GO:0007129)2.69929002
144mitotic spindle organization (GO:0007052)2.69222174
145establishment of synaptic vesicle localization (GO:0097480)2.69024017
146regulation of centrosome cycle (GO:0046605)2.67678832
147negative regulation of chromosome segregation (GO:0051985)2.67407604
148attachment of spindle microtubules to kinetochore (GO:0008608)2.66733459
149negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.65184440
150negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.65184440
151negative regulation of mitotic sister chromatid segregation (GO:0033048)2.65184440
152negative regulation of mitotic sister chromatid separation (GO:2000816)2.65184440
153negative regulation of sister chromatid segregation (GO:0033046)2.65184440
154mitotic spindle assembly checkpoint (GO:0007094)2.63746356
155spindle assembly checkpoint (GO:0071173)2.61520996
156cullin deneddylation (GO:0010388)2.57639252
157microtubule anchoring (GO:0034453)2.56471551
158pre-miRNA processing (GO:0031054)2.52845865
159meiotic chromosome segregation (GO:0045132)2.51109938
160DNA ligation (GO:0006266)2.49163752
161protein localization to chromosome (GO:0034502)2.48081186
162DNA double-strand break processing (GO:0000729)2.43505118
163mitotic cytokinesis (GO:0000281)2.42815854
164tRNA aminoacylation for protein translation (GO:0006418)2.42561350
165tRNA aminoacylation (GO:0043039)2.42038898
166amino acid activation (GO:0043038)2.42038898
167DNA strand elongation involved in DNA replication (GO:0006271)2.39586303
168DNA topological change (GO:0006265)2.38854537
169positive regulation of cell cycle checkpoint (GO:1901978)2.37586904
170negative regulation of DNA recombination (GO:0045910)2.37042638
171DNA synthesis involved in DNA repair (GO:0000731)2.35168940
172glutamine metabolic process (GO:0006541)2.31093957
173DNA duplex unwinding (GO:0032508)2.30865038
174nuclear envelope organization (GO:0006998)2.30593930
175microtubule depolymerization (GO:0007019)2.30452039
176DNA geometric change (GO:0032392)2.29113687
177CENP-A containing nucleosome assembly (GO:0034080)2.28611068
178paraxial mesoderm development (GO:0048339)2.28449933
179DNA strand elongation (GO:0022616)2.28155354
180formation of translation preinitiation complex (GO:0001731)2.27368180
181chromatin remodeling at centromere (GO:0031055)2.27274577
182postreplication repair (GO:0006301)2.25785359
183microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.25367191
184spindle assembly involved in mitosis (GO:0090307)2.25069988
185COPI coating of Golgi vesicle (GO:0048205)2.24306387
186Golgi transport vesicle coating (GO:0048200)2.24306387
187mRNA transport (GO:0051028)2.23812334
188protein K6-linked ubiquitination (GO:0085020)2.22849904
189chromosome segregation (GO:0007059)2.22782475
190protein deneddylation (GO:0000338)2.19752859
191kinetochore assembly (GO:0051382)2.18714142
192cytoskeleton-dependent cytokinesis (GO:0061640)2.18057244
193resolution of meiotic recombination intermediates (GO:0000712)2.17445030
194NLS-bearing protein import into nucleus (GO:0006607)2.16553219
195nucleotide-excision repair, DNA gap filling (GO:0006297)2.16034077
196response to X-ray (GO:0010165)2.14870294
197ATP-dependent chromatin remodeling (GO:0043044)2.14128244
198negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.11504666

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.62248653
2E2F7_22180533_ChIP-Seq_HELA_Human5.46876425
3GBX2_23144817_ChIP-Seq_PC3_Human3.99644878
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.89196595
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.25586589
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.23630925
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.20492226
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89523267
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80946716
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77830479
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52465884
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42847035
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41221650
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41221650
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39668348
16REST_21632747_ChIP-Seq_MESCs_Mouse2.39354568
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.33345769
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30066228
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28883147
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28086395
21ELK1_19687146_ChIP-ChIP_HELA_Human2.22581129
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22433010
23* RARB_27405468_Chip-Seq_BRAIN_Mouse2.18706241
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17401718
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17028051
26AR_21909140_ChIP-Seq_LNCAP_Human2.16937303
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.15239026
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.14310010
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13582077
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.04968453
31TAF15_26573619_Chip-Seq_HEK293_Human2.04885691
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01663568
33AR_21572438_ChIP-Seq_LNCaP_Human2.01553170
34DROSHA_22980978_ChIP-Seq_HELA_Human2.00561296
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.98721679
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95915350
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95611811
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94512100
39SMAD4_21799915_ChIP-Seq_A2780_Human1.94047610
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91081493
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90020250
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89136800
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.88340526
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86055657
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.86021627
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85413417
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77799512
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.76786212
49FUS_26573619_Chip-Seq_HEK293_Human1.76014763
50P300_19829295_ChIP-Seq_ESCs_Human1.75625231
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.72378460
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.71742990
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69804708
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.67470879
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65760104
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.65612330
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.62739434
58* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60949408
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58969808
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.56724012
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56509712
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55437834
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.55208744
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54579728
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54470401
66ZNF274_21170338_ChIP-Seq_K562_Hela1.54193436
67IGF1R_20145208_ChIP-Seq_DFB_Human1.52946324
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52500036
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51983071
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51857909
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.49659484
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48640067
73* STAT3_23295773_ChIP-Seq_U87_Human1.48511161
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48509318
75* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48171864
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.44078426
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.44065297
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43841513
79AR_25329375_ChIP-Seq_VCAP_Human1.42757760
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.41251554
81* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.40043887
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38993519
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37834974
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34831250
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34662008
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34014366
87RNF2_27304074_Chip-Seq_NSC_Mouse1.33671135
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31231104
89* TCF4_23295773_ChIP-Seq_U87_Human1.30477717
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28820932
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28039417
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28021804
93AR_19668381_ChIP-Seq_PC3_Human1.25941533
94NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25886858
95MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25525670
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22021982
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21887627
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.21322295
99DCP1A_22483619_ChIP-Seq_HELA_Human1.21258853
100ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20440474
101HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19554755
102MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18761426
103BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18200988
104SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18137839
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.17649903
106VDR_23849224_ChIP-Seq_CD4+_Human1.15898477
107ER_23166858_ChIP-Seq_MCF-7_Human1.15770272
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15181050
109ETS1_20019798_ChIP-Seq_JURKAT_Human1.15053599
110* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14997769
111FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14526633
112TP53_16413492_ChIP-PET_HCT116_Human1.14435511
113P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14012604
114RUNX2_22187159_ChIP-Seq_PCA_Human1.13409141
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13143767
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12846572
117* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10991671
118TTF2_22483619_ChIP-Seq_HELA_Human1.10916139
119NANOG_18555785_Chip-Seq_ESCs_Mouse1.10630096
120JUN_21703547_ChIP-Seq_K562_Human1.10117066
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09888156
122* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09859612
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09611026
124FLI1_27457419_Chip-Seq_LIVER_Mouse1.09394537
125PRDM14_20953172_ChIP-Seq_ESCs_Human1.09392710
126WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09346654
127RING1B_27294783_Chip-Seq_ESCs_Mouse1.08991362
128EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08833730
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07598661
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07194014
131* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06851018
132FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06660298
133NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05906678
134SOX2_16153702_ChIP-ChIP_HESCs_Human1.05502833
135MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05247031
136* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05010521
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04853247
138MYC_18940864_ChIP-ChIP_HL60_Human1.04553726
139MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04235508
140AHR_22903824_ChIP-Seq_MCF-7_Human1.04161153
141EWS_26573619_Chip-Seq_HEK293_Human1.03436342
142BCAT_22108803_ChIP-Seq_LS180_Human1.03284590
143TP53_18474530_ChIP-ChIP_U2OS_Human1.03112346
144SMAD3_21741376_ChIP-Seq_ESCs_Human1.02537594
145POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02497718
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02497718
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01429705
148RING1B_27294783_Chip-Seq_NPCs_Mouse1.01048808
149TP63_19390658_ChIP-ChIP_HaCaT_Human1.00226702
150VDR_22108803_ChIP-Seq_LS180_Human0.99034450
151SOX9_26525672_Chip-Seq_HEART_Mouse0.98214279
152SOX17_20123909_ChIP-Seq_XEN_Mouse0.93677028
153DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93506967
154FOXP3_21729870_ChIP-Seq_TREG_Human0.93321629
155NANOG_16153702_ChIP-ChIP_HESCs_Human0.93061002
156BRD4_25478319_ChIP-Seq_HGPS_Human0.92098669
157SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91761519
158E2F1_18555785_Chip-Seq_ESCs_Mouse0.87661817
159EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85596343
160E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.84579764
161FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84566215
162HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82943530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.72689271
2MP0003880_abnormal_central_pattern4.98130983
3MP0003635_abnormal_synaptic_transmissio3.86512888
4MP0004270_analgesia3.62632263
5MP0008057_abnormal_DNA_replication3.55239368
6MP0009745_abnormal_behavioral_response3.19573300
7MP0002063_abnormal_learning/memory/cond3.14449051
8MP0010094_abnormal_chromosome_stability2.87485796
9MP0002064_seizures2.83832165
10MP0001968_abnormal_touch/_nociception2.75059814
11MP0009046_muscle_twitch2.68411060
12MP0009780_abnormal_chondrocyte_physiolo2.64491326
13MP0002572_abnormal_emotion/affect_behav2.62156523
14MP0008058_abnormal_DNA_repair2.57713664
15MP0002734_abnormal_mechanical_nocicepti2.54300753
16MP0002272_abnormal_nervous_system2.40385235
17MP0001486_abnormal_startle_reflex2.25205250
18MP0002736_abnormal_nociception_after2.19099114
19MP0003787_abnormal_imprinting2.18254951
20MP0003111_abnormal_nucleus_morphology2.17781109
21MP0001501_abnormal_sleep_pattern2.17051134
22MP0005423_abnormal_somatic_nervous2.13012595
23MP0002735_abnormal_chemical_nociception2.11243229
24MP0003077_abnormal_cell_cycle2.10711879
25MP0001440_abnormal_grooming_behavior2.08164131
26MP0004957_abnormal_blastocyst_morpholog2.06377442
27MP0003693_abnormal_embryo_hatching2.01885898
28MP0000778_abnormal_nervous_system1.99213129
29MP0008932_abnormal_embryonic_tissue1.94478768
30MP0005646_abnormal_pituitary_gland1.90157900
31MP0008007_abnormal_cellular_replicative1.89757162
32MP0002822_catalepsy1.89506608
33MP0002067_abnormal_sensory_capabilities1.86967918
34MP0002733_abnormal_thermal_nociception1.86820596
35MP0003122_maternal_imprinting1.85194345
36MP0002184_abnormal_innervation1.80085886
37MP0006276_abnormal_autonomic_nervous1.78319166
38MP0001970_abnormal_pain_threshold1.78271858
39MP0001188_hyperpigmentation1.71914581
40MP0002557_abnormal_social/conspecific_i1.69807619
41MP0005386_behavior/neurological_phenoty1.68880493
42MP0004924_abnormal_behavior1.68880493
43MP0003890_abnormal_embryonic-extraembry1.67575108
44MP0003937_abnormal_limbs/digits/tail_de1.63349987
45MP0010352_gastrointestinal_tract_polyps1.60109353
46MP0002909_abnormal_adrenal_gland1.59872331
47MP0008569_lethality_at_weaning1.58307170
48MP0004811_abnormal_neuron_physiology1.57648932
49MP0003329_amyloid_beta_deposits1.55255071
50* MP0002084_abnormal_developmental_patter1.51548628
51MP0000955_abnormal_spinal_cord1.49469513
52MP0001293_anophthalmia1.46537907
53MP0005645_abnormal_hypothalamus_physiol1.45151124
54MP0002102_abnormal_ear_morphology1.43406867
55MP0004885_abnormal_endolymph1.38643018
56MP0002882_abnormal_neuron_morphology1.37471300
57MP0003879_abnormal_hair_cell1.36748773
58MP0003385_abnormal_body_wall1.36021603
59MP0001529_abnormal_vocalization1.34210575
60MP0010386_abnormal_urinary_bladder1.32193801
61MP0002233_abnormal_nose_morphology1.31612835
62MP0002066_abnormal_motor_capabilities/c1.30355419
63MP0004858_abnormal_nervous_system1.26669199
64MP0003941_abnormal_skin_development1.25746502
65MP0001730_embryonic_growth_arrest1.25622874
66MP0002938_white_spotting1.25083961
67MP0009697_abnormal_copulation1.24967859
68MP0005248_abnormal_Harderian_gland1.24071087
69MP0000013_abnormal_adipose_tissue1.24000014
70MP0001984_abnormal_olfaction1.22308112
71MP0005380_embryogenesis_phenotype1.21829190
72MP0001672_abnormal_embryogenesis/_devel1.21829190
73MP0002697_abnormal_eye_size1.21331053
74MP0003123_paternal_imprinting1.19942808
75MP0001502_abnormal_circadian_rhythm1.18564444
76MP0004145_abnormal_muscle_electrophysio1.18505196
77* MP0001697_abnormal_embryo_size1.17917028
78MP0003567_abnormal_fetal_cardiomyocyte1.16913900
79MP0003121_genomic_imprinting1.15439869
80* MP0002085_abnormal_embryonic_tissue1.15360419
81MP0001905_abnormal_dopamine_level1.14350223
82MP0003984_embryonic_growth_retardation1.12940437
83MP0002837_dystrophic_cardiac_calcinosis1.12362570
84MP0002152_abnormal_brain_morphology1.12283389
85MP0004197_abnormal_fetal_growth/weight/1.12004045
86MP0009703_decreased_birth_body1.10638309
87MP0000631_abnormal_neuroendocrine_gland1.10054323
88MP0000350_abnormal_cell_proliferation1.09717107
89MP0002088_abnormal_embryonic_growth/wei1.09556451
90MP0002009_preneoplasia1.09312512
91MP0003633_abnormal_nervous_system1.07894476
92MP0001286_abnormal_eye_development1.07086000
93MP0003755_abnormal_palate_morphology1.05081909
94MP0001177_atelectasis1.03083276
95MP0010307_abnormal_tumor_latency1.01742760
96MP0000647_abnormal_sebaceous_gland0.99324235
97MP0003119_abnormal_digestive_system0.98883197
98MP0005551_abnormal_eye_electrophysiolog0.98875906
99MP0005623_abnormal_meninges_morphology0.98767495
100MP0000569_abnormal_digit_pigmentation0.98751614
101MP0003935_abnormal_craniofacial_develop0.98720910
102MP0002751_abnormal_autonomic_nervous0.97845012
103MP0010678_abnormal_skin_adnexa0.97635584
104* MP0002080_prenatal_lethality0.96386897
105MP0009672_abnormal_birth_weight0.94805660
106MP0004142_abnormal_muscle_tone0.94004353
107MP0003631_nervous_system_phenotype0.93742536
108MP0003283_abnormal_digestive_organ0.93101131
109MP0008877_abnormal_DNA_methylation0.92402840
110MP0006072_abnormal_retinal_apoptosis0.91745656
111MP0003718_maternal_effect0.89622215
112MP0001299_abnormal_eye_distance/0.88962064
113MP0004742_abnormal_vestibular_system0.88607744
114MP0004085_abnormal_heartbeat0.87514538
115MP0008789_abnormal_olfactory_epithelium0.86626739
116MP0002069_abnormal_eating/drinking_beha0.85749534
117MP0005409_darkened_coat_color0.85348301
118MP0003943_abnormal_hepatobiliary_system0.85056256
119MP0001963_abnormal_hearing_physiology0.84354556
120MP0010234_abnormal_vibrissa_follicle0.84160024
121MP0002210_abnormal_sex_determination0.82189104
122MP0002229_neurodegeneration0.82136874
123MP0002081_perinatal_lethality0.81923096
124MP0000383_abnormal_hair_follicle0.80559343
125MP0003942_abnormal_urinary_system0.80343002
126MP0002092_abnormal_eye_morphology0.79887039
127MP0000751_myopathy0.78781050
128MP0003115_abnormal_respiratory_system0.78570263
129MP0000428_abnormal_craniofacial_morphol0.78119882
130MP0001929_abnormal_gametogenesis0.78003296
131MP0002177_abnormal_outer_ear0.77602713
132MP0004215_abnormal_myocardial_fiber0.76914173
133MP0004484_altered_response_of0.76655060
134MP0003634_abnormal_glial_cell0.76251104
135MP0005391_vision/eye_phenotype0.76018995
136MP0001661_extended_life_span0.75039216
137MP0000432_abnormal_head_morphology0.74890713
138MP0002876_abnormal_thyroid_physiology0.74044741
139MP0000358_abnormal_cell_content/0.73776525
140MP0002877_abnormal_melanocyte_morpholog0.73692822
141MP0001485_abnormal_pinna_reflex0.73490081
142MP0003786_premature_aging0.73219271
143MP0005187_abnormal_penis_morphology0.73140729
144MP0002752_abnormal_somatic_nervous0.72890501
145MP0003632_abnormal_nervous_system0.71359979
146MP0003861_abnormal_nervous_system0.70860565
147MP0005394_taste/olfaction_phenotype0.70786513
148MP0005499_abnormal_olfactory_system0.70786513
149MP0004233_abnormal_muscle_weight0.67327904
150MP0001943_abnormal_respiration0.66755000
151MP0008872_abnormal_physiological_respon0.66162941
152MP0005535_abnormal_body_temperature0.62215157
153MP0005171_absent_coat_pigmentation0.61669948
154MP0002234_abnormal_pharynx_morphology0.58379153
155MP0004043_abnormal_pH_regulation0.57691031
156MP0008874_decreased_physiological_sensi0.56201435
157MP0006292_abnormal_olfactory_placode0.55634675
158MP0002638_abnormal_pupillary_reflex0.55549595
159MP0001664_abnormal_digestion0.55455030
160MP0008961_abnormal_basal_metabolism0.55281121
161MP0002090_abnormal_vision0.53744963
162MP0000026_abnormal_inner_ear0.53298905
163MP0005253_abnormal_eye_physiology0.53230051

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.93065295
2Focal seizures (HP:0007359)4.95909489
3Visual hallucinations (HP:0002367)4.83352782
4Epileptic encephalopathy (HP:0200134)4.80505803
5Atonic seizures (HP:0010819)4.67212727
6Myokymia (HP:0002411)4.62651077
7Volvulus (HP:0002580)4.02530782
8Febrile seizures (HP:0002373)3.98111083
9Absence seizures (HP:0002121)3.92339111
10Progressive cerebellar ataxia (HP:0002073)3.79285585
11Hyperventilation (HP:0002883)3.53292450
12Broad-based gait (HP:0002136)3.52483102
13Dialeptic seizures (HP:0011146)3.46141711
14Generalized tonic-clonic seizures (HP:0002069)3.30260564
15Action tremor (HP:0002345)2.96157119
16Poor eye contact (HP:0000817)2.93599393
17Chromsome breakage (HP:0040012)2.92940469
18Excessive salivation (HP:0003781)2.92530794
19Drooling (HP:0002307)2.92530794
20Gaze-evoked nystagmus (HP:0000640)2.87086659
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.86112536
22Genetic anticipation (HP:0003743)2.84834834
23Cortical dysplasia (HP:0002539)2.84318010
24Increased nuchal translucency (HP:0010880)2.81068200
25Dysdiadochokinesis (HP:0002075)2.75268440
26Impaired vibration sensation in the lower limbs (HP:0002166)2.74938432
27Amblyopia (HP:0000646)2.72946560
28Termporal pattern (HP:0011008)2.70629502
29Insidious onset (HP:0003587)2.70629502
30Depression (HP:0000716)2.70220124
31Papilledema (HP:0001085)2.66914354
32Truncal ataxia (HP:0002078)2.66907950
33Urinary bladder sphincter dysfunction (HP:0002839)2.65167581
34Supranuclear gaze palsy (HP:0000605)2.60680997
35Absent speech (HP:0001344)2.57668784
36Epileptiform EEG discharges (HP:0011182)2.57169870
37Ankle clonus (HP:0011448)2.56767217
38Anxiety (HP:0000739)2.51387679
39Impaired social interactions (HP:0000735)2.50554682
40Abnormal social behavior (HP:0012433)2.50554682
41Dysmetria (HP:0001310)2.47880789
42Progressive inability to walk (HP:0002505)2.45257801
43EEG with generalized epileptiform discharges (HP:0011198)2.41269264
44Impaired smooth pursuit (HP:0007772)2.40187070
45Protruding tongue (HP:0010808)2.39092587
46Cerebral inclusion bodies (HP:0100314)2.34381875
47Abnormal lung lobation (HP:0002101)2.32454850
48Scanning speech (HP:0002168)2.31666400
49Mutism (HP:0002300)2.31059104
50Abnormality of chromosome stability (HP:0003220)2.30570671
51Abnormality of the astrocytes (HP:0100707)2.30011448
52Astrocytoma (HP:0009592)2.30011448
53Bifid tongue (HP:0010297)2.28291475
54Blue irides (HP:0000635)2.27470840
55Thyroid carcinoma (HP:0002890)2.26115504
56Abnormal eating behavior (HP:0100738)2.25699243
57Hypsarrhythmia (HP:0002521)2.25351434
58Pheochromocytoma (HP:0002666)2.24005002
59Urinary urgency (HP:0000012)2.21711717
60Abnormality of binocular vision (HP:0011514)2.18870280
61Diplopia (HP:0000651)2.18870280
62Abnormality of the corticospinal tract (HP:0002492)2.17056802
63Medulloblastoma (HP:0002885)2.16873387
64Agitation (HP:0000713)2.16797520
65Fetal akinesia sequence (HP:0001989)2.15428179
66Megalencephaly (HP:0001355)2.14568884
67Spastic gait (HP:0002064)2.14188765
68Postural instability (HP:0002172)2.14180253
69Neurofibrillary tangles (HP:0002185)2.13900039
70Hemiparesis (HP:0001269)2.13802761
71Gait imbalance (HP:0002141)2.12548072
72Rhabdomyosarcoma (HP:0002859)2.11474162
73Lower limb muscle weakness (HP:0007340)2.09927556
74Intestinal atresia (HP:0011100)2.08802711
75Nephroblastoma (Wilms tumor) (HP:0002667)2.08478184
76Stereotypic behavior (HP:0000733)2.08150131
77Glioma (HP:0009733)2.07329338
78Inappropriate behavior (HP:0000719)2.06966243
79Abnormality of the labia minora (HP:0012880)2.06184458
80Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04853025
81Abnormality of chromosome segregation (HP:0002916)2.03838259
82Abnormality of ocular smooth pursuit (HP:0000617)2.03675616
83Aplasia/Hypoplasia of the sternum (HP:0006714)2.02143251
84Inability to walk (HP:0002540)2.01474187
85Embryonal renal neoplasm (HP:0011794)2.00855270
86Overlapping toe (HP:0001845)1.99839510
87Abnormality of salivation (HP:0100755)1.99448836
88Colon cancer (HP:0003003)1.99316282
89Oligodactyly (hands) (HP:0001180)1.97936921
90Amyotrophic lateral sclerosis (HP:0007354)1.97633005
91Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.97373568
92Abnormality of the lower motor neuron (HP:0002366)1.96846807
93Limb dystonia (HP:0002451)1.96743763
94Bradykinesia (HP:0002067)1.95735841
95Ependymoma (HP:0002888)1.94780998
96Neuroendocrine neoplasm (HP:0100634)1.92054384
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.91891600
98Pancreatic islet-cell hyperplasia (HP:0004510)1.91269136
99Meckel diverticulum (HP:0002245)1.85832130
100Abnormality of glycolysis (HP:0004366)1.83448567
101Papillary thyroid carcinoma (HP:0002895)1.83443527
102Aqueductal stenosis (HP:0002410)1.82295808
103Abnormality of the ileum (HP:0001549)1.81349880
104Abnormal hair whorl (HP:0010721)1.80739370
105Cystic hygroma (HP:0000476)1.79671625
106Widely spaced teeth (HP:0000687)1.79610976
107Degeneration of the lateral corticospinal tracts (HP:0002314)1.79298227
108Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79298227
109Small intestinal stenosis (HP:0012848)1.78888426
110Duodenal stenosis (HP:0100867)1.78888426
111Hyperthyroidism (HP:0000836)1.78493010
112Generalized myoclonic seizures (HP:0002123)1.78439830
113Torticollis (HP:0000473)1.77274988
114Polyphagia (HP:0002591)1.76857456
115Intention tremor (HP:0002080)1.76479854
116Impaired vibratory sensation (HP:0002495)1.76093021
117Hypoventilation (HP:0002791)1.75053329
118Deep philtrum (HP:0002002)1.74974070
119Congenital primary aphakia (HP:0007707)1.74454557
120Dysmetric saccades (HP:0000641)1.72841046
121Aplasia involving bones of the upper limbs (HP:0009823)1.72547808
122Aplasia of the phalanges of the hand (HP:0009802)1.72547808
123Aplasia involving bones of the extremities (HP:0009825)1.72547808
124Heterotopia (HP:0002282)1.72272620
125Specific learning disability (HP:0001328)1.71787263
126Hepatoblastoma (HP:0002884)1.70977342
127Generalized hypopigmentation of hair (HP:0011358)1.70412198
128Neoplasm of the oral cavity (HP:0100649)1.68653492
129Abnormality of the duodenum (HP:0002246)1.68083780
130Thickened helices (HP:0000391)1.67817899
131Large earlobe (HP:0009748)1.67355367
132Medial flaring of the eyebrow (HP:0010747)1.67130356
133Abnormality of the metopic suture (HP:0005556)1.66557468
134Sporadic (HP:0003745)1.65863678
135Genital tract atresia (HP:0001827)1.65715621
136Central scotoma (HP:0000603)1.64172160
137Buphthalmos (HP:0000557)1.63806040
138Ankyloglossia (HP:0010296)1.63803217
139Abnormal ciliary motility (HP:0012262)1.62796398
140Sloping forehead (HP:0000340)1.62135603
141Proximal placement of thumb (HP:0009623)1.61506520
142Vertebral arch anomaly (HP:0008438)1.61180758
143Relative macrocephaly (HP:0004482)1.60799618
144Obsessive-compulsive behavior (HP:0000722)1.60088898
145Neoplasm of the adrenal cortex (HP:0100641)1.58934649
146Long clavicles (HP:0000890)1.58375202
147Prominent metopic ridge (HP:0005487)1.58317027
148Postnatal microcephaly (HP:0005484)1.57509506
149Deviation of the thumb (HP:0009603)1.55591373
150High anterior hairline (HP:0009890)1.55436403
151Submucous cleft hard palate (HP:0000176)1.53009895
152Increased serum pyruvate (HP:0003542)1.52584834
153Macroorchidism (HP:0000053)1.52160807
154Abnormal auditory evoked potentials (HP:0006958)1.51600623
155Poor coordination (HP:0002370)1.51357145
156Microglossia (HP:0000171)1.50939617
157Facial cleft (HP:0002006)1.50602109
158Shoulder girdle muscle weakness (HP:0003547)1.50006645
159Preaxial hand polydactyly (HP:0001177)1.49750080
160Choanal atresia (HP:0000453)1.48809944
161Abnormality of the preputium (HP:0100587)1.47053028
162Vaginal atresia (HP:0000148)1.46602584
163Oligodactyly (HP:0012165)1.46521310
164Abnormality of methionine metabolism (HP:0010901)1.46061268
165Missing ribs (HP:0000921)1.46047132
166Ectopic kidney (HP:0000086)1.45158194
167Micropenis (HP:0000054)1.44804539
168Nephrogenic diabetes insipidus (HP:0009806)1.44017136
169Acute myeloid leukemia (HP:0004808)1.43084642
170Short tibia (HP:0005736)1.41612187
171Cafe-au-lait spot (HP:0000957)1.41131876
172Neoplasm of the thyroid gland (HP:0100031)1.40529699
173Hyperinsulinemic hypoglycemia (HP:0000825)1.39004070
174Spastic diplegia (HP:0001264)1.38921158
175Truncal obesity (HP:0001956)1.38808726
176Neoplasm of striated muscle (HP:0009728)1.38745230
177Abnormality of endocrine pancreas physiology (HP:0012093)1.38574452
178Abnormality of the pancreatic islet cells (HP:0006476)1.38574452
179Abnormality of the antihelix (HP:0009738)1.38383763
180Abnormality of the carotid arteries (HP:0005344)1.38234065
181Decreased testicular size (HP:0008734)1.37991444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.33283999
2EPHA44.08935970
3MAP3K93.30663812
4MAP3K43.27799473
5MARK13.04686343
6MAP2K72.79820723
7NEK12.69248046
8CASK2.65136871
9SRPK12.63094627
10EIF2AK32.53687423
11MINK12.49407732
12TSSK62.37266720
13PNCK2.34674699
14TTK2.33036160
15CDC72.22461257
16BUB12.19652555
17MKNK12.19146359
18MAP3K122.14465532
19DAPK22.10931230
20PLK22.10259406
21MKNK22.07331056
22TRIM282.00605295
23BRD41.99808050
24PRKD31.96772275
25NTRK11.94511112
26EIF2AK11.94109404
27BRSK21.92854660
28KSR21.90282092
29RIPK41.84909005
30MAP2K41.82484548
31KSR11.80735718
32PAK61.80061095
33NTRK21.75978571
34PBK1.59692708
35MAPK131.57230308
36WEE11.56118944
37PLK41.49148319
38CDK51.42991628
39TNIK1.40671937
40MAP4K21.40041987
41DAPK11.34752435
42PDK21.33212624
43CAMKK11.31076178
44ARAF1.29964700
45PRPF4B1.26656594
46PLK11.25154190
47MAP3K21.22971106
48GRK51.20153385
49MST41.19782321
50BRSK11.13912295
51PRKCG1.12933434
52STK38L1.12804748
53CDK121.12746718
54SIK21.11895292
55MAP3K131.11461983
56ERBB41.10849207
57BMPR21.07654538
58ATR1.07127804
59CAMK2A1.07074086
60SGK4941.04637689
61SGK2231.04637689
62BMPR1B1.04132585
63ATM1.03645229
64PTK2B1.03643398
65SGK21.02836879
66CHEK11.01940143
67CLK11.00315667
68CHEK20.95564963
69FES0.95379562
70CAMKK20.94163477
71TAF10.93701935
72UHMK10.93621944
73LATS20.93598845
74CSNK1G10.93495834
75CAMK2B0.91078979
76PAK30.90122887
77CDK190.89606882
78AKT30.88143638
79LATS10.87498653
80CSNK1A1L0.87320424
81RET0.86555478
82RAF10.85582021
83NEK20.82298049
84CDK140.82259194
85CDK180.82066335
86ZAK0.80591960
87PRKCH0.80193655
88TYRO30.79100511
89CCNB10.78692274
90EIF2AK20.78515391
91CSNK1G30.78098710
92CDK150.77826135
93SGK10.77787889
94DYRK1A0.77342990
95STK30.76011732
96CSNK1G20.75941193
97AURKB0.75702989
98PRKCE0.75622104
99SGK30.75407614
100FER0.75050239
101CDK60.74802801
102STK380.73594136
103OXSR10.71410261
104FGFR20.70033282
105CSNK1E0.68831046
106CDK10.67895096
107FGFR10.66789097
108STK390.65984179
109CAMK10.65301531
110CDK11A0.65110182
111WNK30.64951781
112NUAK10.64731089
113CDK20.63544112
114ERBB30.62932979
115SCYL20.61546911
116MET0.61029663
117FLT30.60943920
118BCR0.60517393
119FRK0.60008334
120STK110.57769433
121BCKDK0.57590224
122CAMK1G0.57158317
123PRKDC0.57011063
124NEK60.56079656
125CAMK2D0.55254094
126NEK90.54589013
127CDK80.53912693
128MUSK0.51603198
129MAP3K60.50682387
130MAP3K10.50644907
131MARK20.50402416
132PHKG10.50001200
133PHKG20.50001200
134NME10.48531488
135WNK10.47620058
136MAPK100.47485116
137EEF2K0.46397009
138AKT20.45842510
139RPS6KA30.45745775
140FGR0.45145544
141BRAF0.44886497
142CDC42BPA0.44771752
143RPS6KA40.43735125
144RPS6KB10.43332630
145MAP2K10.43311602
146DMPK0.43163276
147SIK30.42933657
148PASK0.42453441
149CDK30.41463315
150PKN10.40907588
151CDK70.40328835
152PDK10.39967012
153GSK3B0.39872149
154ROCK20.39626370
155ALK0.39554345
156MAPK140.39492266
157CSNK1D0.39395234
158PLK30.39215415
159PRKCZ0.38857853
160CAMK2G0.36184986
161PDPK10.35933079
162FYN0.34228162
163PRKG10.33228160
164RPS6KA20.32484689
165ADRBK10.32364537

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.63886155
2Non-homologous end-joining_Homo sapiens_hsa034503.34999723
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.06420095
4Synaptic vesicle cycle_Homo sapiens_hsa047213.01822896
5Long-term potentiation_Homo sapiens_hsa047202.73625214
6Circadian entrainment_Homo sapiens_hsa047132.67169628
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66298513
8GABAergic synapse_Homo sapiens_hsa047272.57736709
9Amphetamine addiction_Homo sapiens_hsa050312.53055640
10Glutamatergic synapse_Homo sapiens_hsa047242.46289535
11Morphine addiction_Homo sapiens_hsa050322.44438489
12Olfactory transduction_Homo sapiens_hsa047402.39541111
13Mismatch repair_Homo sapiens_hsa034302.38563977
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32837926
15RNA transport_Homo sapiens_hsa030132.29000181
16Cell cycle_Homo sapiens_hsa041102.20622192
17Dopaminergic synapse_Homo sapiens_hsa047282.20481225
18DNA replication_Homo sapiens_hsa030302.20296632
19Propanoate metabolism_Homo sapiens_hsa006402.06277855
20Insulin secretion_Homo sapiens_hsa049112.04936824
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00885513
22Salivary secretion_Homo sapiens_hsa049701.97330364
23Protein export_Homo sapiens_hsa030601.90202710
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89074484
25Fanconi anemia pathway_Homo sapiens_hsa034601.88884427
26Serotonergic synapse_Homo sapiens_hsa047261.85630995
27Long-term depression_Homo sapiens_hsa047301.85531180
28Taste transduction_Homo sapiens_hsa047421.85388158
29Cholinergic synapse_Homo sapiens_hsa047251.83953554
30Spliceosome_Homo sapiens_hsa030401.83523118
31mRNA surveillance pathway_Homo sapiens_hsa030151.78854030
32Renin secretion_Homo sapiens_hsa049241.76365112
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74939859
34Gastric acid secretion_Homo sapiens_hsa049711.74859011
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74775195
36Steroid biosynthesis_Homo sapiens_hsa001001.73532215
37Nucleotide excision repair_Homo sapiens_hsa034201.70229630
38Cocaine addiction_Homo sapiens_hsa050301.69991516
39Basal transcription factors_Homo sapiens_hsa030221.67531120
40Oxytocin signaling pathway_Homo sapiens_hsa049211.63803845
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58015246
42Collecting duct acid secretion_Homo sapiens_hsa049661.57970977
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57404766
44RNA degradation_Homo sapiens_hsa030181.52288483
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51841122
46Base excision repair_Homo sapiens_hsa034101.50375793
47Homologous recombination_Homo sapiens_hsa034401.49847166
48Calcium signaling pathway_Homo sapiens_hsa040201.48452221
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48213959
50GnRH signaling pathway_Homo sapiens_hsa049121.42309854
51One carbon pool by folate_Homo sapiens_hsa006701.39044212
52Gap junction_Homo sapiens_hsa045401.38768060
53Selenocompound metabolism_Homo sapiens_hsa004501.33701582
54cAMP signaling pathway_Homo sapiens_hsa040241.28093711
55Lysine degradation_Homo sapiens_hsa003101.25782630
56Vibrio cholerae infection_Homo sapiens_hsa051101.25158996
57Estrogen signaling pathway_Homo sapiens_hsa049151.24619890
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21948482
59Axon guidance_Homo sapiens_hsa043601.20896145
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20045944
61Hippo signaling pathway_Homo sapiens_hsa043901.19349654
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17544398
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16931539
64Type II diabetes mellitus_Homo sapiens_hsa049301.16750918
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16522846
66Glioma_Homo sapiens_hsa052141.16132060
67cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15102150
68Proteasome_Homo sapiens_hsa030501.14220213
69Melanogenesis_Homo sapiens_hsa049161.13284644
70Phototransduction_Homo sapiens_hsa047441.12719118
71Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11744191
72Cysteine and methionine metabolism_Homo sapiens_hsa002701.11722282
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11321831
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09375052
75Adherens junction_Homo sapiens_hsa045201.09298394
76ErbB signaling pathway_Homo sapiens_hsa040121.07728284
77Pyruvate metabolism_Homo sapiens_hsa006201.06448119
78Dorso-ventral axis formation_Homo sapiens_hsa043201.05811525
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03785282
80Oocyte meiosis_Homo sapiens_hsa041141.03640175
81Fatty acid elongation_Homo sapiens_hsa000621.02597951
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99446473
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.98787343
84Vitamin B6 metabolism_Homo sapiens_hsa007500.96813046
85Hedgehog signaling pathway_Homo sapiens_hsa043400.96770581
86Biosynthesis of amino acids_Homo sapiens_hsa012300.96394481
87Fatty acid metabolism_Homo sapiens_hsa012120.94945490
88Carbon metabolism_Homo sapiens_hsa012000.92770226
89TGF-beta signaling pathway_Homo sapiens_hsa043500.91702397
90RNA polymerase_Homo sapiens_hsa030200.90613702
91Butanoate metabolism_Homo sapiens_hsa006500.90160206
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87740866
93Thyroid hormone synthesis_Homo sapiens_hsa049180.82633752
94Dilated cardiomyopathy_Homo sapiens_hsa054140.81440867
95Cardiac muscle contraction_Homo sapiens_hsa042600.81383123
96MicroRNAs in cancer_Homo sapiens_hsa052060.80760237
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80406779
98MAPK signaling pathway_Homo sapiens_hsa040100.78455963
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78307550
100Pancreatic secretion_Homo sapiens_hsa049720.78264140
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76604982
102p53 signaling pathway_Homo sapiens_hsa041150.76397665
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75644354
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.75188987
105Basal cell carcinoma_Homo sapiens_hsa052170.73734810
106Type I diabetes mellitus_Homo sapiens_hsa049400.73625607
107Choline metabolism in cancer_Homo sapiens_hsa052310.73335962
108Circadian rhythm_Homo sapiens_hsa047100.69239755
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68803571
110Purine metabolism_Homo sapiens_hsa002300.66652546
111Glucagon signaling pathway_Homo sapiens_hsa049220.66584164
112Alcoholism_Homo sapiens_hsa050340.66403125
113Tight junction_Homo sapiens_hsa045300.65047580
114Wnt signaling pathway_Homo sapiens_hsa043100.65046005
115Ras signaling pathway_Homo sapiens_hsa040140.64730828
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.64358287
117N-Glycan biosynthesis_Homo sapiens_hsa005100.64158915
118Thyroid cancer_Homo sapiens_hsa052160.61408720
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59991865
120Pyrimidine metabolism_Homo sapiens_hsa002400.59385481
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58576257
122Renal cell carcinoma_Homo sapiens_hsa052110.58242447
123Rap1 signaling pathway_Homo sapiens_hsa040150.57831003
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57111955
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56441585
126Endometrial cancer_Homo sapiens_hsa052130.55519731
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55260857
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55136731
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55057595
130VEGF signaling pathway_Homo sapiens_hsa043700.54641373
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54200555
132Inositol phosphate metabolism_Homo sapiens_hsa005620.53259793
133mTOR signaling pathway_Homo sapiens_hsa041500.52414573
134Ovarian steroidogenesis_Homo sapiens_hsa049130.51872094
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51128284
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.50543824
137AMPK signaling pathway_Homo sapiens_hsa041520.49865946
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48704851
139Colorectal cancer_Homo sapiens_hsa052100.47935308
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47704999
141Central carbon metabolism in cancer_Homo sapiens_hsa052300.46685832
142Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45250139
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44249663
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42761103
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42420001
146Fatty acid biosynthesis_Homo sapiens_hsa000610.42075462
147Endocytosis_Homo sapiens_hsa041440.41875267
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41462979
149Non-small cell lung cancer_Homo sapiens_hsa052230.41347643
150Alzheimers disease_Homo sapiens_hsa050100.41245060
151Insulin signaling pathway_Homo sapiens_hsa049100.39625314
152Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39033665
153Prostate cancer_Homo sapiens_hsa052150.38576484
154Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37753423
155Pentose phosphate pathway_Homo sapiens_hsa000300.36738109
156Proteoglycans in cancer_Homo sapiens_hsa052050.36486045
157Regulation of autophagy_Homo sapiens_hsa041400.36437539
158Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35913143
159Melanoma_Homo sapiens_hsa052180.35080047
160Prolactin signaling pathway_Homo sapiens_hsa049170.34884383
161Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32282087
162African trypanosomiasis_Homo sapiens_hsa051430.32110263
163Prion diseases_Homo sapiens_hsa050200.31485358
164Rheumatoid arthritis_Homo sapiens_hsa053230.30514249
165Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30404301
166Chemokine signaling pathway_Homo sapiens_hsa040620.29832435
167Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29699977

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