ZFR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.25473742
2synaptic vesicle maturation (GO:0016188)5.79573557
3locomotory exploration behavior (GO:0035641)5.57770635
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.41056680
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.40593777
6vocalization behavior (GO:0071625)5.26625792
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.08649950
8synaptic vesicle exocytosis (GO:0016079)5.04405741
9behavioral response to nicotine (GO:0035095)4.96029209
10regulation of synaptic vesicle exocytosis (GO:2000300)4.84574799
11protein localization to synapse (GO:0035418)4.80138064
12regulation of glutamate receptor signaling pathway (GO:1900449)4.67132209
13glutamate secretion (GO:0014047)4.65245136
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.61778691
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.59178053
16regulation of synaptic vesicle transport (GO:1902803)4.40654218
17neuron cell-cell adhesion (GO:0007158)4.37705908
18exploration behavior (GO:0035640)4.36939769
19regulation of neuronal synaptic plasticity (GO:0048168)4.32191650
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.27471229
21synaptic transmission, glutamatergic (GO:0035249)4.22692622
22regulation of synapse structural plasticity (GO:0051823)4.21620258
23neurotransmitter secretion (GO:0007269)4.15907608
24glutamate receptor signaling pathway (GO:0007215)4.10716460
25pyrimidine nucleobase catabolic process (GO:0006208)4.09507818
26neuronal action potential propagation (GO:0019227)4.09484185
27positive regulation of synaptic transmission, GABAergic (GO:0032230)4.08875660
28dendritic spine morphogenesis (GO:0060997)4.03330343
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.94483761
30long-term memory (GO:0007616)3.91465967
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.89694110
32neuron-neuron synaptic transmission (GO:0007270)3.88867095
33neurotransmitter-gated ion channel clustering (GO:0072578)3.85206717
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83140111
35postsynaptic membrane organization (GO:0001941)3.79432213
36layer formation in cerebral cortex (GO:0021819)3.73886883
37positive regulation of membrane potential (GO:0045838)3.71347849
38transmission of nerve impulse (GO:0019226)3.69528868
39gamma-aminobutyric acid transport (GO:0015812)3.68249177
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.64379577
41proline transport (GO:0015824)3.58065666
42neuron recognition (GO:0008038)3.52098810
43cellular potassium ion homeostasis (GO:0030007)3.51697460
44regulation of postsynaptic membrane potential (GO:0060078)3.49716921
45response to pheromone (GO:0019236)3.46294755
46neurotransmitter transport (GO:0006836)3.44623422
47cell communication by electrical coupling (GO:0010644)3.43769462
48regulation of neurotransmitter secretion (GO:0046928)3.41144783
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.40047864
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.39647854
51nucleobase catabolic process (GO:0046113)3.39277763
52auditory behavior (GO:0031223)3.39214195
53synaptic vesicle endocytosis (GO:0048488)3.38219079
54membrane depolarization during action potential (GO:0086010)3.36121036
55regulation of vesicle fusion (GO:0031338)3.35996776
56sodium ion export (GO:0071436)3.34146271
57neuronal ion channel clustering (GO:0045161)3.32754636
58regulation of synaptic plasticity (GO:0048167)3.30615015
59response to auditory stimulus (GO:0010996)3.30547583
60protein polyglutamylation (GO:0018095)3.30126307
61axonal fasciculation (GO:0007413)3.26820615
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.26783070
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.26486853
64cerebellar Purkinje cell differentiation (GO:0021702)3.26356691
65membrane hyperpolarization (GO:0060081)3.25810100
66presynaptic membrane assembly (GO:0097105)3.23538203
67positive regulation of neurotransmitter secretion (GO:0001956)3.22741179
68positive regulation of neurotransmitter transport (GO:0051590)3.22187724
69regulation of neurotransmitter transport (GO:0051588)3.19359122
70positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.18810492
71negative regulation of synaptic transmission, GABAergic (GO:0032229)3.17995794
72protein neddylation (GO:0045116)3.17486095
73membrane depolarization (GO:0051899)3.15664761
74gamma-aminobutyric acid signaling pathway (GO:0007214)3.13590046
75protein complex biogenesis (GO:0070271)3.13432527
76prepulse inhibition (GO:0060134)3.13119618
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.13019944
78water-soluble vitamin biosynthetic process (GO:0042364)3.12577573
79long-term synaptic potentiation (GO:0060291)3.11848476
80neuromuscular process controlling posture (GO:0050884)3.10611215
81regulation of neurotransmitter levels (GO:0001505)3.10419866
82positive regulation of synapse maturation (GO:0090129)3.09730314
83DNA deamination (GO:0045006)3.08611851
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.08032800
85synapse assembly (GO:0007416)3.07920704
86neuromuscular process controlling balance (GO:0050885)3.07067355
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.07005727
88regulation of dendritic spine morphogenesis (GO:0061001)3.06653851
89dendrite morphogenesis (GO:0048813)3.05876389
90learning (GO:0007612)3.05002993
91activation of protein kinase A activity (GO:0034199)3.03886973
92kynurenine metabolic process (GO:0070189)3.03729996
93innervation (GO:0060384)3.02928091
94glycine transport (GO:0015816)3.01821328
95mitochondrial respiratory chain complex I assembly (GO:0032981)3.01794733
96NADH dehydrogenase complex assembly (GO:0010257)3.01794733
97mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01794733
98piRNA metabolic process (GO:0034587)3.01303445
99presynaptic membrane organization (GO:0097090)3.00444640
100regulation of synaptic transmission, GABAergic (GO:0032228)2.99873672
101neurofilament cytoskeleton organization (GO:0060052)2.99312881
102positive regulation of dendritic spine development (GO:0060999)2.98459610
103L-fucose catabolic process (GO:0042355)2.96872649
104fucose catabolic process (GO:0019317)2.96872649
105L-fucose metabolic process (GO:0042354)2.96872649
106response to histamine (GO:0034776)2.96193275
107tryptophan metabolic process (GO:0006568)2.96024829
108nonmotile primary cilium assembly (GO:0035058)2.94859809
109mechanosensory behavior (GO:0007638)2.93095611
110positive regulation of synaptic transmission (GO:0050806)2.91728106
111dendritic spine organization (GO:0097061)2.91258038
112somatic hypermutation of immunoglobulin genes (GO:0016446)2.90367549
113somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90367549
114visual learning (GO:0008542)2.90336949
115positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88183478
116indolalkylamine metabolic process (GO:0006586)2.87273669
117retinal cone cell development (GO:0046549)2.86834753
118regulation of synaptic transmission (GO:0050804)2.86280247
119mitochondrial respiratory chain complex assembly (GO:0033108)2.85872655
120chemosensory behavior (GO:0007635)2.85730476
121synaptic transmission (GO:0007268)2.85541155
122central nervous system projection neuron axonogenesis (GO:0021952)2.84254357
123indole-containing compound catabolic process (GO:0042436)2.83551125
124indolalkylamine catabolic process (GO:0046218)2.83551125
125tryptophan catabolic process (GO:0006569)2.83551125
126axoneme assembly (GO:0035082)2.82538155
127adult walking behavior (GO:0007628)2.82391658
128primary amino compound metabolic process (GO:1901160)2.82066096
129striatum development (GO:0021756)2.80782961
130DNA methylation involved in gamete generation (GO:0043046)2.76315959
131DNA double-strand break processing (GO:0000729)2.73443401
132respiratory chain complex IV assembly (GO:0008535)2.72771509
133epithelial cilium movement (GO:0003351)2.69709579
134platelet dense granule organization (GO:0060155)2.68959871
135regulation of cilium movement (GO:0003352)2.68245142
136serotonin metabolic process (GO:0042428)2.67189931
137detection of light stimulus involved in sensory perception (GO:0050962)2.65998319
138detection of light stimulus involved in visual perception (GO:0050908)2.65998319
139protein-cofactor linkage (GO:0018065)2.64460973
140fear response (GO:0042596)2.64355703
141negative regulation of telomere maintenance (GO:0032205)2.61265142
142cell proliferation in forebrain (GO:0021846)2.60835098
143epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60662996
144positive regulation of cAMP-mediated signaling (GO:0043950)2.55656127
145regulation of action potential (GO:0098900)2.54667740
146C4-dicarboxylate transport (GO:0015740)2.54244301
147neuronal action potential (GO:0019228)2.53806788
148regulation of microtubule-based movement (GO:0060632)2.48809069
149positive regulation of mitochondrial fission (GO:0090141)2.48799896
150negative regulation of transcription regulatory region DNA binding (GO:2000678)2.48415010
151mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.47846673
152regulation of neurotransmitter uptake (GO:0051580)2.47226611
153detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.45910616
154indole-containing compound metabolic process (GO:0042430)2.45756057
155startle response (GO:0001964)2.43069921
156negative regulation of systemic arterial blood pressure (GO:0003085)2.42079237
157glycosphingolipid biosynthetic process (GO:0006688)2.41197168
158cilium morphogenesis (GO:0060271)2.41150843
159behavioral response to ethanol (GO:0048149)2.40470441
160cytochrome complex assembly (GO:0017004)2.39080168
161chaperone-mediated protein transport (GO:0072321)2.38788167
162protein localization to cilium (GO:0061512)2.38239468
163photoreceptor cell development (GO:0042461)2.38040096
164regulation of rhodopsin mediated signaling pathway (GO:0022400)2.36533448
165anterograde axon cargo transport (GO:0008089)2.34593929
166retinal ganglion cell axon guidance (GO:0031290)2.33975598
167neuromuscular synaptic transmission (GO:0007274)2.32921447
168synaptic transmission, cholinergic (GO:0007271)2.31586699
169negative regulation of cytosolic calcium ion concentration (GO:0051481)2.31341601
170regulation of collateral sprouting (GO:0048670)2.31040097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.45198011
2GBX2_23144817_ChIP-Seq_PC3_Human3.55219645
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98622165
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.98388336
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96845842
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90072458
7REST_21632747_ChIP-Seq_MESCs_Mouse2.68530315
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64210194
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62341645
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62341645
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.58224788
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.56541976
13DROSHA_22980978_ChIP-Seq_HELA_Human2.54330925
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53912823
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50182268
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48141322
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44274583
18VDR_22108803_ChIP-Seq_LS180_Human2.44206735
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.37066092
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.35975447
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35734485
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35231892
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.33462723
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.32993192
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.26365188
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.23022026
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12256368
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.08069763
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05202000
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87330835
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86899503
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85549931
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.81622128
34IRF1_19129219_ChIP-ChIP_H3396_Human1.76654380
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74345313
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72920573
37FUS_26573619_Chip-Seq_HEK293_Human1.72223542
38AR_21572438_ChIP-Seq_LNCaP_Human1.70417035
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67777371
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.63865006
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61688179
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56816392
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53046627
44TP53_22573176_ChIP-Seq_HFKS_Human1.52719814
45EWS_26573619_Chip-Seq_HEK293_Human1.52232743
46SMAD4_21799915_ChIP-Seq_A2780_Human1.52200679
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50807578
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45865623
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44844367
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44457120
51ZNF274_21170338_ChIP-Seq_K562_Hela1.42438361
52TAF15_26573619_Chip-Seq_HEK293_Human1.42003194
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41344832
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40557748
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.39942917
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39881865
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39417510
58IGF1R_20145208_ChIP-Seq_DFB_Human1.38585224
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38205218
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37494666
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37192591
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.36504183
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.33805296
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.33345857
65MYC_18940864_ChIP-ChIP_HL60_Human1.32140497
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31544432
67ER_23166858_ChIP-Seq_MCF-7_Human1.27795625
68P300_19829295_ChIP-Seq_ESCs_Human1.27752838
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26590969
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26256811
71BCAT_22108803_ChIP-Seq_LS180_Human1.25390660
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.24872896
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24111229
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22333355
75CBP_20019798_ChIP-Seq_JUKART_Human1.21990703
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21990703
77AR_25329375_ChIP-Seq_VCAP_Human1.20744018
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20610649
79RNF2_27304074_Chip-Seq_NSC_Mouse1.20329606
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19429094
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.19325628
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18982361
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18235755
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.17939993
85STAT3_23295773_ChIP-Seq_U87_Human1.17904595
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.17676108
87AR_19668381_ChIP-Seq_PC3_Human1.16879856
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14942516
89SOX2_19829295_ChIP-Seq_ESCs_Human1.14345885
90NANOG_19829295_ChIP-Seq_ESCs_Human1.14345885
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13291751
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12131241
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11653206
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.10929775
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09367536
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.09172590
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07057199
98TCF4_22108803_ChIP-Seq_LS180_Human1.06669293
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.06603694
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06362709
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06089645
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06054633
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.06003467
104TCF4_23295773_ChIP-Seq_U87_Human1.04514274
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03286173
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02225187
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02225187
108FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01770441
109FOXA1_25329375_ChIP-Seq_VCAP_Human1.01770441
110NCOR_22424771_ChIP-Seq_293T_Human1.00632255
111RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99904837
112ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99825178
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98504711
114CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98466764
115CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98394438
116SMAD4_21741376_ChIP-Seq_EPCs_Human0.98340784
117NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97892345
118YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97372098
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.97294360
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96745251
121ETS1_20019798_ChIP-Seq_JURKAT_Human0.96636363
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96408532
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96200635
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96087362
125GATA3_21878914_ChIP-Seq_MCF-7_Human0.95604565
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.95050752
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94357432
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.93212491
129KDM2B_26808549_Chip-Seq_K562_Human0.92961208
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92111692
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91318052
132RUNX2_22187159_ChIP-Seq_PCA_Human0.91243839
133EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91070721
134AHR_22903824_ChIP-Seq_MCF-7_Human0.90257235
135POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90087387
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.90055637
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89320675
138SMAD3_21741376_ChIP-Seq_HESCs_Human0.87786176
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86651497
140PRDM14_20953172_ChIP-Seq_ESCs_Human0.85817863
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84606270
142OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84561119
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84381384
144GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84376905
145NANOG_18555785_Chip-Seq_ESCs_Mouse0.83044935
146TET1_21490601_ChIP-Seq_MESCs_Mouse0.82783082
147WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82688995

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.10754558
2MP0003880_abnormal_central_pattern4.70960666
3MP0003635_abnormal_synaptic_transmissio3.95062828
4MP0004270_analgesia3.39204384
5MP0009745_abnormal_behavioral_response3.30699369
6MP0005423_abnormal_somatic_nervous3.19725909
7MP0002063_abnormal_learning/memory/cond3.17177157
8MP0008877_abnormal_DNA_methylation3.15240669
9MP0002064_seizures2.93064599
10MP0001968_abnormal_touch/_nociception2.82551884
11MP0009046_muscle_twitch2.81146331
12MP0002572_abnormal_emotion/affect_behav2.69226345
13MP0001486_abnormal_startle_reflex2.58055659
14MP0002822_catalepsy2.57457487
15MP0002734_abnormal_mechanical_nocicepti2.56532744
16MP0002272_abnormal_nervous_system2.52299449
17MP0002102_abnormal_ear_morphology2.30770644
18MP0002735_abnormal_chemical_nociception2.29130109
19MP0001501_abnormal_sleep_pattern2.23816955
20MP0005646_abnormal_pituitary_gland2.12024068
21MP0001440_abnormal_grooming_behavior2.00355666
22MP0002736_abnormal_nociception_after2.00001098
23MP0002067_abnormal_sensory_capabilities1.97139298
24MP0002653_abnormal_ependyma_morphology1.94627849
25MP0002733_abnormal_thermal_nociception1.93999069
26MP0002557_abnormal_social/conspecific_i1.93127984
27MP0001970_abnormal_pain_threshold1.92723688
28MP0002184_abnormal_innervation1.92057218
29MP0008569_lethality_at_weaning1.91578714
30MP0006276_abnormal_autonomic_nervous1.91509340
31MP0005645_abnormal_hypothalamus_physiol1.91191182
32MP0001984_abnormal_olfaction1.85420893
33MP0002909_abnormal_adrenal_gland1.77653004
34MP0000778_abnormal_nervous_system1.69848433
35MP0001502_abnormal_circadian_rhythm1.69536952
36MP0001188_hyperpigmentation1.69465681
37MP0004811_abnormal_neuron_physiology1.69122936
38MP0003787_abnormal_imprinting1.64909171
39MP0004858_abnormal_nervous_system1.62769937
40MP0003879_abnormal_hair_cell1.62573231
41MP0000569_abnormal_digit_pigmentation1.59490132
42MP0004133_heterotaxia1.57297931
43MP0004924_abnormal_behavior1.55644079
44MP0005386_behavior/neurological_phenoty1.55644079
45MP0000955_abnormal_spinal_cord1.54533169
46MP0003122_maternal_imprinting1.54236405
47MP0009780_abnormal_chondrocyte_physiolo1.53875016
48MP0001529_abnormal_vocalization1.49123129
49MP0010386_abnormal_urinary_bladder1.45553597
50MP0002882_abnormal_neuron_morphology1.44942437
51MP0008789_abnormal_olfactory_epithelium1.43254639
52MP0003329_amyloid_beta_deposits1.41203147
53MP0004142_abnormal_muscle_tone1.37744990
54MP0005551_abnormal_eye_electrophysiolog1.36812672
55MP0004885_abnormal_endolymph1.34292224
56MP0002066_abnormal_motor_capabilities/c1.32940916
57MP0002163_abnormal_gland_morphology1.30383520
58MP0000372_irregular_coat_pigmentation1.30034656
59MP0006292_abnormal_olfactory_placode1.26770842
60MP0003195_calcinosis1.26694534
61MP0001905_abnormal_dopamine_level1.26459579
62MP0002638_abnormal_pupillary_reflex1.24898930
63MP0003633_abnormal_nervous_system1.24229981
64MP0003011_delayed_dark_adaptation1.17835094
65MP0004145_abnormal_muscle_electrophysio1.15548836
66MP0004147_increased_porphyrin_level1.13046058
67MP0003646_muscle_fatigue1.12472225
68MP0003890_abnormal_embryonic-extraembry1.09411242
69MP0005377_hearing/vestibular/ear_phenot1.04627173
70MP0003878_abnormal_ear_physiology1.04627173
71MP0002152_abnormal_brain_morphology1.04312986
72MP0002229_neurodegeneration1.03938908
73MP0005379_endocrine/exocrine_gland_phen1.03896017
74MP0003283_abnormal_digestive_organ1.01894486
75MP0008058_abnormal_DNA_repair1.01404183
76MP0005084_abnormal_gallbladder_morpholo1.00911446
77MP0000631_abnormal_neuroendocrine_gland1.00741243
78MP0002160_abnormal_reproductive_system1.00214103
79MP0003631_nervous_system_phenotype0.98771889
80MP0002069_abnormal_eating/drinking_beha0.97014517
81MP0005195_abnormal_posterior_eye0.96650654
82MP0002938_white_spotting0.93296090
83MP0003119_abnormal_digestive_system0.93134157
84MP0002837_dystrophic_cardiac_calcinosis0.93079452
85MP0000049_abnormal_middle_ear0.92761606
86MP0008961_abnormal_basal_metabolism0.91646236
87MP0004742_abnormal_vestibular_system0.90761351
88MP0005499_abnormal_olfactory_system0.90170980
89MP0005394_taste/olfaction_phenotype0.90170980
90MP0001177_atelectasis0.90134969
91MP0001963_abnormal_hearing_physiology0.89547139
92MP0008875_abnormal_xenobiotic_pharmacok0.88600578
93MP0000751_myopathy0.88106590
94MP0003698_abnormal_male_reproductive0.87033698
95MP0002752_abnormal_somatic_nervous0.86417698
96MP0005083_abnormal_biliary_tract0.84859490
97MP0001986_abnormal_taste_sensitivity0.84436199
98MP0005410_abnormal_fertilization0.84215135
99MP0004085_abnormal_heartbeat0.83600594
100MP0004043_abnormal_pH_regulation0.83559171
101MP0002210_abnormal_sex_determination0.83525539
102MP0000427_abnormal_hair_cycle0.83186740
103MP0005389_reproductive_system_phenotype0.82635854
104MP0001293_anophthalmia0.82574590
105MP0003136_yellow_coat_color0.82102508
106MP0005171_absent_coat_pigmentation0.81838332
107MP0008872_abnormal_physiological_respon0.79429428
108MP0000013_abnormal_adipose_tissue0.79227888
109MP0008874_decreased_physiological_sensi0.77353507
110MP0002090_abnormal_vision0.75896170
111MP0006072_abnormal_retinal_apoptosis0.75306497
112MP0002876_abnormal_thyroid_physiology0.73761324
113MP0003137_abnormal_impulse_conducting0.73083788
114MP0003172_abnormal_lysosome_physiology0.72677264
115MP0005253_abnormal_eye_physiology0.72325524
116MP0001664_abnormal_digestion0.72090694
117MP0004510_myositis0.71780776
118MP0003634_abnormal_glial_cell0.70496565
119MP0001299_abnormal_eye_distance/0.69329640
120MP0001485_abnormal_pinna_reflex0.68215650
121MP0005535_abnormal_body_temperature0.67642483
122MP0003690_abnormal_glial_cell0.66901526
123MP0002234_abnormal_pharynx_morphology0.62849449
124MP0003632_abnormal_nervous_system0.59427494
125MP0000026_abnormal_inner_ear0.58692137
126MP0000920_abnormal_myelination0.58444142
127MP0003075_altered_response_to0.58191257
128MP0003183_abnormal_peptide_metabolism0.56793271
129MP0002751_abnormal_autonomic_nervous0.55652776
130MP0003121_genomic_imprinting0.52500310
131MP0001943_abnormal_respiration0.52027222
132MP0010769_abnormal_survival0.51819603
133MP0005409_darkened_coat_color0.51764671
134MP0003861_abnormal_nervous_system0.51242059

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.77817863
2Myokymia (HP:0002411)6.70241407
3Focal seizures (HP:0007359)5.57898004
4Visual hallucinations (HP:0002367)5.20359691
5Febrile seizures (HP:0002373)5.02711438
6Epileptic encephalopathy (HP:0200134)4.89109385
7Progressive cerebellar ataxia (HP:0002073)4.25885072
8Atonic seizures (HP:0010819)3.94146267
9Absence seizures (HP:0002121)3.72871660
10Molar tooth sign on MRI (HP:0002419)3.71771057
11Abnormality of midbrain morphology (HP:0002418)3.71771057
12Supranuclear gaze palsy (HP:0000605)3.65377259
13Pancreatic cysts (HP:0001737)3.64674760
14Action tremor (HP:0002345)3.55081393
15Generalized tonic-clonic seizures (HP:0002069)3.54395116
16Pancreatic fibrosis (HP:0100732)3.53969108
17True hermaphroditism (HP:0010459)3.48911374
18Type II lissencephaly (HP:0007260)3.39658841
19Ankle clonus (HP:0011448)3.39657667
20Dialeptic seizures (HP:0011146)3.39305236
21Broad-based gait (HP:0002136)3.31336470
22Poor eye contact (HP:0000817)3.28640283
23Depression (HP:0000716)3.24364345
24Gaze-evoked nystagmus (HP:0000640)3.11017980
25Abnormality of the labia minora (HP:0012880)3.08250294
26Medial flaring of the eyebrow (HP:0010747)2.99370714
27Impaired social interactions (HP:0000735)2.94642834
28Abnormal social behavior (HP:0012433)2.94642834
29Mutism (HP:0002300)2.94606961
30Nephronophthisis (HP:0000090)2.93575863
31Hemiparesis (HP:0001269)2.91062351
32Abnormal eating behavior (HP:0100738)2.89485443
33Postural instability (HP:0002172)2.85780654
34Truncal ataxia (HP:0002078)2.81581643
35Pendular nystagmus (HP:0012043)2.78848856
36Urinary bladder sphincter dysfunction (HP:0002839)2.78273025
37Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.77737097
38Impaired vibration sensation in the lower limbs (HP:0002166)2.73218101
39Torticollis (HP:0000473)2.73194033
40Limb dystonia (HP:0002451)2.72759283
41Anxiety (HP:0000739)2.70780681
42Dysdiadochokinesis (HP:0002075)2.65697735
43Lissencephaly (HP:0001339)2.65074373
44Amblyopia (HP:0000646)2.63633966
45Genetic anticipation (HP:0003743)2.62788080
46Excessive salivation (HP:0003781)2.58416485
47Drooling (HP:0002307)2.58416485
48Hyperventilation (HP:0002883)2.57801324
49Acute necrotizing encephalopathy (HP:0006965)2.54651156
50Abolished electroretinogram (ERG) (HP:0000550)2.53249815
51Focal dystonia (HP:0004373)2.50021915
52Dysmetria (HP:0001310)2.45401718
53Cerebellar dysplasia (HP:0007033)2.42866160
54Mitochondrial inheritance (HP:0001427)2.42431658
55Congenital primary aphakia (HP:0007707)2.42381272
56Bradykinesia (HP:0002067)2.40174336
57Abnormality of the renal medulla (HP:0100957)2.38356615
58Polyphagia (HP:0002591)2.37317918
59Spastic gait (HP:0002064)2.36806249
60Nephrogenic diabetes insipidus (HP:0009806)2.32693606
61Hemiplegia (HP:0002301)2.32466335
62Ventricular fibrillation (HP:0001663)2.32095529
63Impaired smooth pursuit (HP:0007772)2.31738965
64Absent speech (HP:0001344)2.30626612
65Stereotypic behavior (HP:0000733)2.30066590
66Epileptiform EEG discharges (HP:0011182)2.29883932
67Sclerocornea (HP:0000647)2.28275922
68Abnormality of the lower motor neuron (HP:0002366)2.28092065
69Agitation (HP:0000713)2.27336964
70EEG with generalized epileptiform discharges (HP:0011198)2.25434263
71Cystic liver disease (HP:0006706)2.25244986
72Progressive inability to walk (HP:0002505)2.24955913
73Craniofacial dystonia (HP:0012179)2.24107563
74Colon cancer (HP:0003003)2.23516344
75Fetal akinesia sequence (HP:0001989)2.22311493
76Acute encephalopathy (HP:0006846)2.21850649
77Anencephaly (HP:0002323)2.21422667
78Increased CSF lactate (HP:0002490)2.20745973
79Abnormal mitochondria in muscle tissue (HP:0008316)2.19650295
80Genital tract atresia (HP:0001827)2.19367772
81Papilledema (HP:0001085)2.18927668
82Vaginal atresia (HP:0000148)2.18860043
83Failure to thrive in infancy (HP:0001531)2.17368838
84Hyperglycinemia (HP:0002154)2.15371015
85Abnormality of binocular vision (HP:0011514)2.14477078
86Diplopia (HP:0000651)2.14477078
87Hypothermia (HP:0002045)2.14200672
88Abnormal rod and cone electroretinograms (HP:0008323)2.14131857
89Pachygyria (HP:0001302)2.13372481
90Congenital stationary night blindness (HP:0007642)2.13101272
91Progressive macrocephaly (HP:0004481)2.12081052
92Intestinal atresia (HP:0011100)2.11230711
93Spinal canal stenosis (HP:0003416)2.11225362
94Hypsarrhythmia (HP:0002521)2.10510716
95Abnormality of alanine metabolism (HP:0010916)2.08970737
96Hyperalaninemia (HP:0003348)2.08970737
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08970737
98Insomnia (HP:0100785)2.08648636
99Lipid accumulation in hepatocytes (HP:0006561)2.06747344
100Megalencephaly (HP:0001355)2.05518411
101Tubular atrophy (HP:0000092)2.05511661
102Hepatocellular necrosis (HP:0001404)2.05409673
103Abnormal EKG (HP:0003115)2.05081084
104Scanning speech (HP:0002168)2.04907638
105Lower limb muscle weakness (HP:0007340)2.04777783
106Decreased central vision (HP:0007663)2.02845737
107Inability to walk (HP:0002540)2.02812985
108Hypoventilation (HP:0002791)2.02391007
109Increased hepatocellular lipid droplets (HP:0006565)2.02154035
110Abnormality of the pons (HP:0007361)2.01037219
111Abnormality of the renal cortex (HP:0011035)2.00833052
112Absent/shortened dynein arms (HP:0200106)2.00282349
113Dynein arm defect of respiratory motile cilia (HP:0012255)2.00282349
114Methylmalonic acidemia (HP:0002912)2.00026963
115Attenuation of retinal blood vessels (HP:0007843)1.98928315
116Hypoplasia of the pons (HP:0012110)1.98765689
117Urinary urgency (HP:0000012)1.98075970
1183-Methylglutaconic aciduria (HP:0003535)1.97100777
119Prolonged QT interval (HP:0001657)1.96761939
120Abnormality of ocular smooth pursuit (HP:0000617)1.96480112
121Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94204251
122Abnormal drinking behavior (HP:0030082)1.93476374
123Polydipsia (HP:0001959)1.93476374
124Male pseudohermaphroditism (HP:0000037)1.93226485
125Pointed chin (HP:0000307)1.92202809
126Neurofibrillary tangles (HP:0002185)1.91352127
127Optic nerve hypoplasia (HP:0000609)1.90333161
128Blue irides (HP:0000635)1.90234915
129Increased corneal curvature (HP:0100692)1.86313583
130Keratoconus (HP:0000563)1.86313583
131Sleep apnea (HP:0010535)1.86169493
132Anosmia (HP:0000458)1.85907026
133Intention tremor (HP:0002080)1.85104366
134Retinal dysplasia (HP:0007973)1.84183600
135Neoplasm of the heart (HP:0100544)1.83164580
136Psychosis (HP:0000709)1.83149891
137Status epilepticus (HP:0002133)1.82432345
138Central scotoma (HP:0000603)1.82176842
139Gait imbalance (HP:0002141)1.81247096
140Bony spicule pigmentary retinopathy (HP:0007737)1.80611965
141Specific learning disability (HP:0001328)1.79867226
142Abnormality of calcium-phosphate metabolism (HP:0100530)1.79852647
143Oligodactyly (hands) (HP:0001180)1.79398138
144Aplasia/Hypoplasia of the tongue (HP:0010295)1.78040220
145Aplasia/Hypoplasia of the spleen (HP:0010451)1.77326995
146Chronic hepatic failure (HP:0100626)1.77232753
147Exotropia (HP:0000577)1.77136791
148Rigidity (HP:0002063)1.76533890
149Elfin facies (HP:0004428)1.75357345
150Protruding tongue (HP:0010808)1.74936764
151Abnormal ciliary motility (HP:0012262)1.74799250
152Akinesia (HP:0002304)1.74086869
153Dandy-Walker malformation (HP:0001305)1.73862480
154Impaired vibratory sensation (HP:0002495)1.73655583
155Optic disc pallor (HP:0000543)1.72758492
156Abnormal respiratory epithelium morphology (HP:0012253)1.72689947
157Abnormal respiratory motile cilium morphology (HP:0005938)1.72689947
158Pheochromocytoma (HP:0002666)1.72474055
159Postaxial hand polydactyly (HP:0001162)1.72471946
160Incomplete penetrance (HP:0003829)1.72463783
161Supernumerary spleens (HP:0009799)1.71982901
162Annular pancreas (HP:0001734)1.71047525
163Aplasia/Hypoplasia of the brainstem (HP:0007362)1.70950685
164Hypoplasia of the brainstem (HP:0002365)1.70950685
165Aplasia of the phalanges of the hand (HP:0009802)1.70653168
166Methylmalonic aciduria (HP:0012120)1.70528229
167Postaxial foot polydactyly (HP:0001830)1.68907094
168Polyuria (HP:0000103)1.68317396
169Hepatic necrosis (HP:0002605)1.68246460
170Poor coordination (HP:0002370)1.67526818

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.69813214
2EPHA43.92989050
3MAP3K93.31739335
4MARK13.13653922
5FRK2.82025966
6MAP4K22.73956234
7MINK12.64669093
8ADRBK22.59773829
9MAP2K72.58257888
10MAP3K42.49196904
11ZAK2.39097648
12BMPR1B2.37937439
13NTRK22.33004022
14DAPK22.26720377
15PRKD32.24076839
16TNIK2.19381610
17RIPK42.07099449
18GRK12.05493328
19CASK2.05284480
20CAMKK12.02739064
21PAK62.01785281
22MAP3K122.01569422
23TRIM281.98092745
24DYRK21.97783488
25PRPF4B1.96805127
26NUAK11.83393611
27NTRK11.73272670
28MAP2K41.70319975
29WNK41.70171308
30CAMKK21.65116416
31KSR11.63619587
32MAPK131.58988755
33KSR21.57167484
34TLK11.55501252
35CDK51.54682079
36INSRR1.46045143
37SIK21.44318531
38ACVR1B1.42586295
39TXK1.40820155
40VRK11.36339221
41STK381.36238615
42UHMK11.27083381
43CSNK1G31.24521106
44CSNK1G11.22127442
45BCKDK1.20337336
46GRK51.17876280
47CDK191.17768425
48PHKG21.17457942
49PHKG11.17457942
50TNK21.16517640
51ARAF1.13171406
52CAMK11.12078478
53DAPK11.11124464
54PRKCG1.10120040
55MAP3K21.07537422
56SGK2231.06860551
57SGK4941.06860551
58CSNK1A1L1.02396874
59MAP3K131.01390664
60SIK30.98780149
61PINK10.98082756
62FES0.97668352
63PLK20.96681180
64PRKCI0.91020403
65STK390.90991483
66MKNK20.90821351
67SGK20.90751223
68BMPR20.89500886
69CAMK2A0.89373399
70PLK30.85973494
71CDC42BPA0.85912770
72NEK60.83854363
73TYRO30.83592724
74LMTK20.82993366
75DYRK1A0.81135989
76WNK30.79244374
77PRKCH0.79104731
78PAK30.79021792
79MARK20.75317100
80SGK10.74330286
81STK160.73567510
82STK110.73513865
83MUSK0.73436488
84CDK180.72897844
85MAP3K10.71879285
86TAOK10.71706306
87RET0.70973906
88WNK10.70193354
89ADRBK10.69085423
90PKN10.68796233
91CDK150.67843343
92PNCK0.67610119
93DYRK30.64666393
94CDK140.63767569
95CAMK1G0.63662628
96CSNK1G20.63650802
97SGK30.62087676
98CAMK2B0.60046916
99PRKCQ0.59391098
100FGFR20.58480784
101CDK11A0.58076886
102PLK10.58005049
103TIE10.57267809
104FER0.56202491
105TSSK60.55755964
106PRKACA0.54984700
107PRKCE0.54678681
108CDK30.54165273
109CSNK1A10.53839064
110OXSR10.53237408
111RAF10.52716405
112TAF10.52540126
113PLK40.52040761
114VRK20.51867739
115PDK10.50529521
116CAMK40.50330966
117BCR0.50286035
118AKT30.50165683
119MAPKAPK50.50026602
120EPHA30.49989101
121RPS6KA50.49624274
122LATS20.49078742
123BRAF0.48289117
124CCNB10.47440723
125PRKCZ0.46537025
126MAPK150.46516377
127PDPK10.45878615
128ERBB30.45439110
129RPS6KA30.45111368
130FYN0.44478824
131ALK0.44232074
132NME10.43331407
133BRSK10.43252148
134IRAK20.42556986
135TGFBR10.42207966
136CSNK1E0.41573555
137ATR0.41550835
138MAP2K60.41493969
139PRKCA0.39823521
140MAPK100.39465749
141LIMK10.39331303
142RPS6KA20.39127729
143BUB10.38636041
144STK38L0.38457084
145CSNK1D0.38398340
146BRSK20.37891678
147PRKAA10.37286304
148CAMK2D0.36805643
149TAOK30.36608182
150PTK2B0.35637856
151AURKA0.34667910
152MAP3K70.34666895
153CDC70.33988646

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77456981
2Synaptic vesicle cycle_Homo sapiens_hsa047213.33085177
3Olfactory transduction_Homo sapiens_hsa047402.80442013
4Circadian entrainment_Homo sapiens_hsa047132.72643858
5GABAergic synapse_Homo sapiens_hsa047272.70985776
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66596691
7Oxidative phosphorylation_Homo sapiens_hsa001902.65997368
8Glutamatergic synapse_Homo sapiens_hsa047242.65053802
9Morphine addiction_Homo sapiens_hsa050322.57819002
10Long-term potentiation_Homo sapiens_hsa047202.42415026
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35633317
12Parkinsons disease_Homo sapiens_hsa050122.33386644
13Amphetamine addiction_Homo sapiens_hsa050312.30006231
14Insulin secretion_Homo sapiens_hsa049112.19420256
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11471453
16Dopaminergic synapse_Homo sapiens_hsa047282.07117296
17Salivary secretion_Homo sapiens_hsa049702.05244982
18Cholinergic synapse_Homo sapiens_hsa047251.96112238
19RNA polymerase_Homo sapiens_hsa030201.96082502
20Taste transduction_Homo sapiens_hsa047421.94951551
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91479795
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88412132
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87861672
24Serotonergic synapse_Homo sapiens_hsa047261.81992424
25Butanoate metabolism_Homo sapiens_hsa006501.79941068
26Protein export_Homo sapiens_hsa030601.77904233
27Cocaine addiction_Homo sapiens_hsa050301.70093976
28Gastric acid secretion_Homo sapiens_hsa049711.65434194
29Basal transcription factors_Homo sapiens_hsa030221.65114135
30Calcium signaling pathway_Homo sapiens_hsa040201.64957879
31Long-term depression_Homo sapiens_hsa047301.63576816
32Selenocompound metabolism_Homo sapiens_hsa004501.63571941
33Oxytocin signaling pathway_Homo sapiens_hsa049211.60095277
34Linoleic acid metabolism_Homo sapiens_hsa005911.56983903
35Renin secretion_Homo sapiens_hsa049241.56455205
36Huntingtons disease_Homo sapiens_hsa050161.55518612
37Nitrogen metabolism_Homo sapiens_hsa009101.53602576
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52342637
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49947219
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46263156
41Alzheimers disease_Homo sapiens_hsa050101.45865181
42Regulation of autophagy_Homo sapiens_hsa041401.43027591
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40046334
44GnRH signaling pathway_Homo sapiens_hsa049121.39148435
45Type II diabetes mellitus_Homo sapiens_hsa049301.37582147
46Phototransduction_Homo sapiens_hsa047441.35163379
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32908647
48Fanconi anemia pathway_Homo sapiens_hsa034601.32512506
49Collecting duct acid secretion_Homo sapiens_hsa049661.31451683
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29600556
51Tryptophan metabolism_Homo sapiens_hsa003801.28386625
52Steroid biosynthesis_Homo sapiens_hsa001001.28309240
53Homologous recombination_Homo sapiens_hsa034401.27677038
54Gap junction_Homo sapiens_hsa045401.27387715
55cAMP signaling pathway_Homo sapiens_hsa040241.25914479
56Ether lipid metabolism_Homo sapiens_hsa005651.24519800
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24146446
58Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21381529
59RNA degradation_Homo sapiens_hsa030181.20772218
60Axon guidance_Homo sapiens_hsa043601.18667002
61Propanoate metabolism_Homo sapiens_hsa006401.12518659
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09105890
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08107675
64ErbB signaling pathway_Homo sapiens_hsa040121.08075226
65Proteasome_Homo sapiens_hsa030501.07537973
66Melanogenesis_Homo sapiens_hsa049161.03806478
67cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02163520
68Caffeine metabolism_Homo sapiens_hsa002321.01168173
69Glioma_Homo sapiens_hsa052141.00665511
70Estrogen signaling pathway_Homo sapiens_hsa049151.00653486
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00418116
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.98661634
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95091113
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.91680868
75Vibrio cholerae infection_Homo sapiens_hsa051100.91228392
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.87217857
77Pancreatic secretion_Homo sapiens_hsa049720.86737454
78Cardiac muscle contraction_Homo sapiens_hsa042600.86621765
79Peroxisome_Homo sapiens_hsa041460.85752507
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81131014
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78828492
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77980593
83Type I diabetes mellitus_Homo sapiens_hsa049400.77322615
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76677955
85Circadian rhythm_Homo sapiens_hsa047100.76450401
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76265944
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75492236
88MAPK signaling pathway_Homo sapiens_hsa040100.75014699
89Dilated cardiomyopathy_Homo sapiens_hsa054140.74676693
90beta-Alanine metabolism_Homo sapiens_hsa004100.73205968
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72896079
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72209490
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69179424
94Dorso-ventral axis formation_Homo sapiens_hsa043200.67877931
95Thyroid hormone synthesis_Homo sapiens_hsa049180.66880864
96Purine metabolism_Homo sapiens_hsa002300.66810967
97Choline metabolism in cancer_Homo sapiens_hsa052310.66639682
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66171268
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65015267
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.64302998
101One carbon pool by folate_Homo sapiens_hsa006700.64188894
102Inositol phosphate metabolism_Homo sapiens_hsa005620.63832471
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.62044076
104Ras signaling pathway_Homo sapiens_hsa040140.61385102
105Basal cell carcinoma_Homo sapiens_hsa052170.61380458
106Oocyte meiosis_Homo sapiens_hsa041140.61199870
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.60290193
108VEGF signaling pathway_Homo sapiens_hsa043700.60128471
109Fatty acid elongation_Homo sapiens_hsa000620.59011461
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58225574
111Metabolic pathways_Homo sapiens_hsa011000.58021192
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57946945
113Sulfur relay system_Homo sapiens_hsa041220.55582611
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55442752
115Retinol metabolism_Homo sapiens_hsa008300.55254039
116Ovarian steroidogenesis_Homo sapiens_hsa049130.54404691
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53869397
118Alcoholism_Homo sapiens_hsa050340.53433784
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.52959145
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51288931
121Rap1 signaling pathway_Homo sapiens_hsa040150.51004608
122Wnt signaling pathway_Homo sapiens_hsa043100.50184203
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50095548
124Arginine and proline metabolism_Homo sapiens_hsa003300.49415520
125Chemical carcinogenesis_Homo sapiens_hsa052040.49364838
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49069126
127Fat digestion and absorption_Homo sapiens_hsa049750.48295796
128Glucagon signaling pathway_Homo sapiens_hsa049220.47856152
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.47745647
130Endometrial cancer_Homo sapiens_hsa052130.47207148
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45744621
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45493023
133Systemic lupus erythematosus_Homo sapiens_hsa053220.44680478
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43828953
135Pyrimidine metabolism_Homo sapiens_hsa002400.43649643
136Endocytosis_Homo sapiens_hsa041440.42786752
137RNA transport_Homo sapiens_hsa030130.42670255
138Prion diseases_Homo sapiens_hsa050200.40846420
139Non-small cell lung cancer_Homo sapiens_hsa052230.40606300
140Non-homologous end-joining_Homo sapiens_hsa034500.39717479
141Chemokine signaling pathway_Homo sapiens_hsa040620.38680516
142Mineral absorption_Homo sapiens_hsa049780.38554094
143Arachidonic acid metabolism_Homo sapiens_hsa005900.38052289
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37912525
145Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36866447
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36041518
147Insulin signaling pathway_Homo sapiens_hsa049100.35963384
148mTOR signaling pathway_Homo sapiens_hsa041500.34474669
149Prolactin signaling pathway_Homo sapiens_hsa049170.33594395
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.33308721
151Renal cell carcinoma_Homo sapiens_hsa052110.28876042
152Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28329867
153Rheumatoid arthritis_Homo sapiens_hsa053230.28108452
154Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27703231
155Bile secretion_Homo sapiens_hsa049760.27518409
156Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26510590
157Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25345478
158Hedgehog signaling pathway_Homo sapiens_hsa043400.24623868

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