ZFX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.42351432
2nuclear pore complex assembly (GO:0051292)5.02941906
3mitotic sister chromatid cohesion (GO:0007064)4.63174267
4nuclear pore organization (GO:0006999)4.59702527
5protein K11-linked deubiquitination (GO:0035871)4.22304851
6DNA double-strand break processing (GO:0000729)4.12521575
7protein prenylation (GO:0018342)4.09245366
8prenylation (GO:0097354)4.09245366
9pore complex assembly (GO:0046931)3.80463534
10positive regulation of glycoprotein biosynthetic process (GO:0010560)3.71493609
11keratinocyte development (GO:0003334)3.68774177
12positive regulation of protein autophosphorylation (GO:0031954)3.49730547
13monoubiquitinated protein deubiquitination (GO:0035520)3.44501595
14regulation of DNA endoreduplication (GO:0032875)3.33851638
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.32509142
16replication fork processing (GO:0031297)3.30519063
17fibroblast migration (GO:0010761)3.28464220
18DNA unwinding involved in DNA replication (GO:0006268)3.27911585
19regulation of RNA export from nucleus (GO:0046831)3.27482806
20definitive hemopoiesis (GO:0060216)3.26335667
21lactate metabolic process (GO:0006089)3.25934217
22DNA topological change (GO:0006265)3.21883452
23mitotic chromosome condensation (GO:0007076)3.21866991
24protein localization to kinetochore (GO:0034501)3.17963335
25dosage compensation (GO:0007549)3.16813559
26RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.16512157
27regulation of spindle organization (GO:0090224)3.16042609
28mitotic nuclear envelope disassembly (GO:0007077)3.15118448
29positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.14152099
30positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.14152099
31positive regulation of mitotic sister chromatid separation (GO:1901970)3.14152099
32somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.13294492
33isotype switching (GO:0045190)3.13294492
34somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.13294492
35cellular response to ethanol (GO:0071361)3.10816714
36establishment of protein localization to Golgi (GO:0072600)3.09130608
37genitalia morphogenesis (GO:0035112)3.08970188
38kinetochore organization (GO:0051383)3.07504532
39protein targeting to Golgi (GO:0000042)2.97811550
40membrane disassembly (GO:0030397)2.97610360
41nuclear envelope disassembly (GO:0051081)2.97610360
42ketone body metabolic process (GO:1902224)2.96999136
43regulation of mitotic spindle organization (GO:0060236)2.94235201
44histone mRNA catabolic process (GO:0071044)2.93517715
45negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.93506246
46negative regulation of T-helper cell differentiation (GO:0045623)2.93506246
47synapsis (GO:0007129)2.93279580
48DNA deamination (GO:0045006)2.91124085
49protein K6-linked ubiquitination (GO:0085020)2.90099491
50dorsal/ventral axis specification (GO:0009950)2.89999377
51prostate gland growth (GO:0060736)2.87582489
52UDP-N-acetylglucosamine metabolic process (GO:0006047)2.87257443
53Golgi transport vesicle coating (GO:0048200)2.85273333
54COPI coating of Golgi vesicle (GO:0048205)2.85273333
55neural tube formation (GO:0001841)2.84220294
56Rap protein signal transduction (GO:0032486)2.83101221
57response to X-ray (GO:0010165)2.81190094
58retrograde transport, vesicle recycling within Golgi (GO:0000301)2.80591384
59regulation of hexokinase activity (GO:1903299)2.79728204
60regulation of glucokinase activity (GO:0033131)2.79728204
61sister chromatid segregation (GO:0000819)2.78361260
62regulation of nuclear cell cycle DNA replication (GO:0033262)2.76857913
63double-strand break repair via homologous recombination (GO:0000724)2.76247499
64response to pheromone (GO:0019236)2.74748384
65recombinational repair (GO:0000725)2.73831525
66negative regulation of translation, ncRNA-mediated (GO:0040033)2.73489918
67regulation of translation, ncRNA-mediated (GO:0045974)2.73489918
68negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73489918
69DNA duplex unwinding (GO:0032508)2.73461273
70DNA geometric change (GO:0032392)2.73068668
71regulation of B cell apoptotic process (GO:0002902)2.72919192
72mitotic metaphase plate congression (GO:0007080)2.71050632
73cornea development in camera-type eye (GO:0061303)2.70813616
74N-terminal protein amino acid acetylation (GO:0006474)2.69124080
75metaphase plate congression (GO:0051310)2.68032828
76RNA stabilization (GO:0043489)2.67260803
77mRNA stabilization (GO:0048255)2.67260803
78positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.67228276
79pericardium development (GO:0060039)2.67211550
80negative regulation of histone methylation (GO:0031061)2.66570391
81protein localization to chromosome, centromeric region (GO:0071459)2.65029358
82regulation of histone H3-K9 methylation (GO:0051570)2.64784599
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62872840
84regulation of sister chromatid cohesion (GO:0007063)2.61331783
85embryonic process involved in female pregnancy (GO:0060136)2.60889650
86regulation of nucleobase-containing compound transport (GO:0032239)2.58719412
87regulation of protein autophosphorylation (GO:0031952)2.58632805
88chromatin assembly (GO:0031497)2.57561556
89histone H2A monoubiquitination (GO:0035518)2.57044500
90positive regulation of gamma-delta T cell activation (GO:0046645)2.56139622
91inositol phosphate catabolic process (GO:0071545)2.55270445
92IMP biosynthetic process (GO:0006188)2.54214247
93polyol catabolic process (GO:0046174)2.54168757
94NLS-bearing protein import into nucleus (GO:0006607)2.53519778
95protein localization to Golgi apparatus (GO:0034067)2.53489427
96positive regulation of glycoprotein metabolic process (GO:1903020)2.53047400
97negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.51873461
98positive regulation of chromosome segregation (GO:0051984)2.51604943
99intestinal epithelial cell development (GO:0060576)2.50036390
100adenosine metabolic process (GO:0046085)2.49750146
101positive regulation of glycolytic process (GO:0045821)2.48852330
102microtubule anchoring (GO:0034453)2.48707272
103negative regulation of alpha-beta T cell differentiation (GO:0046639)2.48564425
104interkinetic nuclear migration (GO:0022027)2.47219777
105regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.46682789
106DNA replication-dependent nucleosome assembly (GO:0006335)2.46524048
107DNA replication-dependent nucleosome organization (GO:0034723)2.46524048
108sister chromatid cohesion (GO:0007062)2.46395501
109positive regulation of cell cycle G1/S phase transition (GO:1902808)2.45700715
1103-UTR-mediated mRNA stabilization (GO:0070935)2.45609520
111glucocorticoid receptor signaling pathway (GO:0042921)2.45472183
112meiotic chromosome segregation (GO:0045132)2.45040043
113regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.44245098
114histone-serine phosphorylation (GO:0035404)2.44023018
115negative regulation of DNA-dependent DNA replication (GO:2000104)2.43950244
116positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.43177318
117maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.42367464
118protein localization to chromosome (GO:0034502)2.42085799
119phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.40646637
120pancreas development (GO:0031016)2.39393817
121negative regulation of complement activation (GO:0045916)2.38560769
122antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.38315953
123antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.38315953
124translesion synthesis (GO:0019985)2.37921460
125regulation of acyl-CoA biosynthetic process (GO:0050812)2.37103708
126negative regulation of DNA repair (GO:0045738)2.36782161
127negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.36536905
128DNA conformation change (GO:0071103)2.35410921
129regulation of protein glycosylation (GO:0060049)2.35296386
130establishment of chromosome localization (GO:0051303)2.35189818
131inositol phosphate dephosphorylation (GO:0046855)2.34635470
132phosphorylated carbohydrate dephosphorylation (GO:0046838)2.34635470
133regulation of sulfur metabolic process (GO:0042762)2.34549471
134chromatin assembly or disassembly (GO:0006333)2.34331065
135regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.34111527
136magnesium ion transport (GO:0015693)2.33759970
137germ cell migration (GO:0008354)2.33664775
138positive regulation of protein import into nucleus, translocation (GO:0033160)2.32970948
139ribosome assembly (GO:0042255)2.31826587
140artery development (GO:0060840)2.31633429
141nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.31341505
142protein K63-linked deubiquitination (GO:0070536)2.30855531
143DNA replication-independent nucleosome organization (GO:0034724)2.30427342
144DNA replication-independent nucleosome assembly (GO:0006336)2.30427342
145pre-miRNA processing (GO:0031054)2.29851356
146somatic diversification of immunoglobulins (GO:0016445)2.29770547
147rRNA catabolic process (GO:0016075)2.29711049
148positive regulation of histone H3-K4 methylation (GO:0051571)2.29448044
149regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.29440392
150histone H2A acetylation (GO:0043968)2.29292588
151histone H2A ubiquitination (GO:0033522)2.29010114
152double-strand break repair via nonhomologous end joining (GO:0006303)2.28970727
153non-recombinational repair (GO:0000726)2.28970727
154attachment of spindle microtubules to kinetochore (GO:0008608)2.28965565
155regulation of interferon-alpha production (GO:0032647)2.28359566
156nuclear envelope organization (GO:0006998)2.28191844
157regulation of relaxation of muscle (GO:1901077)2.28092616
158alternative mRNA splicing, via spliceosome (GO:0000380)2.28045266
159regulation of centriole replication (GO:0046599)2.27844493
160corticosteroid receptor signaling pathway (GO:0031958)2.27504806
161mitotic G2 DNA damage checkpoint (GO:0007095)2.27306705
162mitotic G2/M transition checkpoint (GO:0044818)2.25403216
163mitotic recombination (GO:0006312)2.25168882
164negative regulation of glycogen biosynthetic process (GO:0045719)2.23874943
165spindle checkpoint (GO:0031577)2.23624203
166mitotic DNA integrity checkpoint (GO:0044774)2.21830371
167negative regulation of RNA splicing (GO:0033119)2.20697464
168kinetochore assembly (GO:0051382)2.20500957
169positive regulation of SMAD protein import into nucleus (GO:0060391)2.20089933
170CENP-A containing nucleosome assembly (GO:0034080)2.19531226
171cytoplasmic mRNA processing body assembly (GO:0033962)2.19166884
172regulation of mRNA stability (GO:0043488)2.18971964
173regulation of mitotic metaphase/anaphase transition (GO:0030071)2.18933274
174chromatin remodeling at centromere (GO:0031055)2.16541553
175regulation of gamma-delta T cell differentiation (GO:0045586)2.15735720
176spindle assembly checkpoint (GO:0071173)2.14131260
177regulation of chromosome segregation (GO:0051983)2.13453512
178regulation of SMAD protein import into nucleus (GO:0060390)2.13421979
179regulation of telomere maintenance via telomerase (GO:0032210)2.12773113
180chromosome condensation (GO:0030261)2.12724662
181antigen processing and presentation of endogenous antigen (GO:0019883)2.12595707
182regulation of interleukin-12 biosynthetic process (GO:0045075)2.12362154
183negative regulation of phagocytosis (GO:0050765)2.11644688
184regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.10996035
185folic acid-containing compound biosynthetic process (GO:0009396)2.10843949
186mRNA transport (GO:0051028)2.09143351
187IMP metabolic process (GO:0046040)2.08828822

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.48709333
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.91856013
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.36104422
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.20579090
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.52329939
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.26237586
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.07472380
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88591156
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.84260787
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79451935
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.58741581
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.51983755
13MYC_22102868_ChIP-Seq_BL_Human2.37241723
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36553837
15GBX2_23144817_ChIP-Seq_PC3_Human2.33017778
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.32982691
17FUS_26573619_Chip-Seq_HEK293_Human2.30531923
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.27355185
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.26345166
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21570344
21AR_21909140_ChIP-Seq_LNCAP_Human2.19190404
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.19146639
23EWS_26573619_Chip-Seq_HEK293_Human2.15491938
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.14402691
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.09364890
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09338104
27IRF8_22096565_ChIP-ChIP_GC-B_Human2.08324524
28MYC_18555785_ChIP-Seq_MESCs_Mouse2.07372113
29ZNF274_21170338_ChIP-Seq_K562_Hela2.05420947
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03267124
31TAF15_26573619_Chip-Seq_HEK293_Human2.00084421
32P300_19829295_ChIP-Seq_ESCs_Human1.98307858
33GATA1_22025678_ChIP-Seq_K562_Human1.97180181
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.93026514
35VDR_22108803_ChIP-Seq_LS180_Human1.90535294
36ELK1_19687146_ChIP-ChIP_HELA_Human1.83324216
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.80343849
38IGF1R_20145208_ChIP-Seq_DFB_Human1.78670294
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.77897935
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71310564
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69703374
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69637644
43ER_23166858_ChIP-Seq_MCF-7_Human1.68574669
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.66404923
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61433476
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61398345
47* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57505841
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57202073
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56890080
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56478849
51SMAD4_21799915_ChIP-Seq_A2780_Human1.56139331
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54144733
53BCAT_22108803_ChIP-Seq_LS180_Human1.53861915
54CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.53166558
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52954038
56FOXM1_26456572_ChIP-Seq_MCF-7_Human1.52223936
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.52092307
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51690061
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49465054
60* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49340032
61MYB_26560356_Chip-Seq_TH2_Human1.47062531
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46456748
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46054600
64* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44860669
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44463994
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44085887
67CLOCK_20551151_ChIP-Seq_293T_Human1.42234981
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41399870
69STAT3_23295773_ChIP-Seq_U87_Human1.40610309
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40090381
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39372558
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38515866
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38155268
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.38150477
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37733522
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36535045
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36267272
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35942201
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.34427446
80* MYB_26560356_Chip-Seq_TH1_Human1.34005949
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32827198
82TP53_16413492_ChIP-PET_HCT116_Human1.32750716
83CDX2_22108803_ChIP-Seq_LS180_Human1.32350880
84* CIITA_25753668_ChIP-Seq_RAJI_Human1.32246062
85VDR_23849224_ChIP-Seq_CD4+_Human1.31548999
86* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.31486262
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31277499
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31206002
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30915670
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30171689
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30058247
92* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29964960
93SCL_19346495_ChIP-Seq_HPC-7_Human1.29302216
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.29176719
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28622128
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.28578134
97NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27941882
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27941882
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27365891
100CBP_20019798_ChIP-Seq_JUKART_Human1.26597988
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26597988
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26594095
103* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25863627
104AR_25329375_ChIP-Seq_VCAP_Human1.24228024
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24011734
106P53_22387025_ChIP-Seq_ESCs_Mouse1.23810675
107BRD4_25478319_ChIP-Seq_HGPS_Human1.23615270
108* SPI1_23547873_ChIP-Seq_NB4_Human1.23565531
109SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.22977053
110TCF4_23295773_ChIP-Seq_U87_Human1.22162328
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.22080845
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21728750
113KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21493799
114NOTCH1_21737748_ChIP-Seq_TLL_Human1.21483062
115* TCF7_22412390_ChIP-Seq_EML_Mouse1.19637455
116MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18776111
117TFEB_21752829_ChIP-Seq_HELA_Human1.18395385
118TCF4_22108803_ChIP-Seq_LS180_Human1.17803600
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17555019
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.15959480
121MAF_26560356_Chip-Seq_TH1_Human1.15123218
122PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14691327
123VDR_21846776_ChIP-Seq_THP-1_Human1.13751801
124TP63_17297297_ChIP-ChIP_HaCaT_Human1.13644200
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.13568866
126BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12956809
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12573337
128* IRF8_27001747_Chip-Seq_BMDM_Mouse1.12454009
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12280964
130SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12122845
131SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11690618
132CJUN_26792858_Chip-Seq_BT549_Human1.10224896
133* IRF8_21731497_ChIP-ChIP_J774_Mouse1.10224871
134* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10057546
135EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09612277
136TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09475496
137P300_18555785_Chip-Seq_ESCs_Mouse1.09134526
138ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08809471
139UTX_26944678_Chip-Seq_JUKART_Human1.08348140
140STAT3_18555785_Chip-Seq_ESCs_Mouse1.07888478
141STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04778951
142ARNT_22903824_ChIP-Seq_MCF-7_Human1.04501760
143XRN2_22483619_ChIP-Seq_HELA_Human1.04441287
144SOX2_18555785_Chip-Seq_ESCs_Mouse1.04184971
145OCT4_18555785_Chip-Seq_ESCs_Mouse1.04058368
146SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03514149
147KDM5A_27292631_Chip-Seq_BREAST_Human1.03336798
148NANOG_19829295_ChIP-Seq_ESCs_Human1.03055265
149SOX2_19829295_ChIP-Seq_ESCs_Human1.03055265
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02937770
151MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02446330
152AHR_22903824_ChIP-Seq_MCF-7_Human1.01902828
153FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01043859
154* SALL4_22934838_ChIP-ChIP_CD34+_Human1.00896229
155SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00776646
156SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00776646
157FOXP3_21729870_ChIP-Seq_TREG_Human1.00385594
158EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00168941
159CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00142254
160POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99556322
161MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99185500
162CHD1_26751641_Chip-Seq_LNCaP_Human0.97884157
163FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97851191
164RUNX2_22187159_ChIP-Seq_PCA_Human0.97790407
165GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97720475
166POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97436549
167RUNX_20019798_ChIP-Seq_JUKART_Human0.97374017
168KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97294409
169NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95460754
170HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94644360
171IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93897376
172RUNX1_22412390_ChIP-Seq_EML_Mouse0.93766087
173WT1_19549856_ChIP-ChIP_CCG9911_Human0.92514285
174* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92330501
175CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92206854
176RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91761537
177CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.89092704
178CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89078217
179VDR_24763502_ChIP-Seq_THP-1_Human0.86973033
180CREB1_15753290_ChIP-ChIP_HEK293T_Human0.85811796
181SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85583760
182PU_27001747_Chip-Seq_BMDM_Mouse0.85277537
183SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84458639

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation3.76873800
2MP0002102_abnormal_ear_morphology3.48389474
3MP0010352_gastrointestinal_tract_polyps2.79792723
4MP0003195_calcinosis2.70387165
5MP0002396_abnormal_hematopoietic_system2.66179609
6MP0008877_abnormal_DNA_methylation2.38906069
7MP0003693_abnormal_embryo_hatching2.38073832
8MP0005171_absent_coat_pigmentation2.30225174
9MP0003950_abnormal_plasma_membrane2.28317712
10MP0008438_abnormal_cutaneous_collagen2.28009484
11MP0010307_abnormal_tumor_latency2.16659986
12MP0008057_abnormal_DNA_replication2.14473911
13* MP0004808_abnormal_hematopoietic_stem2.14471565
14MP0010094_abnormal_chromosome_stability2.13917294
15MP0002166_altered_tumor_susceptibility2.13191518
16MP0005075_abnormal_melanosome_morpholog2.10378017
17MP0003077_abnormal_cell_cycle2.07599996
18MP0000427_abnormal_hair_cycle2.01971902
19MP0005076_abnormal_cell_differentiation2.01436750
20MP0002877_abnormal_melanocyte_morpholog1.96849325
21MP0003111_abnormal_nucleus_morphology1.91518445
22MP0006054_spinal_hemorrhage1.86084289
23MP0002938_white_spotting1.86023175
24MP0003705_abnormal_hypodermis_morpholog1.85057132
25MP0009697_abnormal_copulation1.82602232
26MP0008007_abnormal_cellular_replicative1.82003321
27MP0003300_gastrointestinal_ulcer1.76245503
28MP0002009_preneoplasia1.75216254
29MP0002876_abnormal_thyroid_physiology1.71884585
30MP0004957_abnormal_blastocyst_morpholog1.71522732
31MP0005174_abnormal_tail_pigmentation1.70695894
32MP0003787_abnormal_imprinting1.69093338
33MP0002006_tumorigenesis1.64457195
34MP0000015_abnormal_ear_pigmentation1.64268909
35MP0000569_abnormal_digit_pigmentation1.62779095
36MP0005503_abnormal_tendon_morphology1.57906595
37MP0005397_hematopoietic_system_phenotyp1.40834771
38MP0001545_abnormal_hematopoietic_system1.40834771
39MP0003646_muscle_fatigue1.40663685
40MP0004484_altered_response_of1.39975718
41MP0001661_extended_life_span1.38835369
42MP0001835_abnormal_antigen_presentation1.37506518
43MP0010234_abnormal_vibrissa_follicle1.36825886
44MP0003786_premature_aging1.36303615
45MP0000350_abnormal_cell_proliferation1.36193917
46MP0005275_abnormal_skin_tensile1.35960878
47MP0005253_abnormal_eye_physiology1.34178513
48MP0004197_abnormal_fetal_growth/weight/1.33614542
49MP0005408_hypopigmentation1.32014471
50MP0003567_abnormal_fetal_cardiomyocyte1.31576514
51MP0003566_abnormal_cell_adhesion1.30707873
52MP0003763_abnormal_thymus_physiology1.30164629
53MP0009278_abnormal_bone_marrow1.29282899
54MP0000490_abnormal_crypts_of1.29089637
55* MP0002086_abnormal_extraembryonic_tissu1.28228019
56MP0002168_other_aberrant_phenotype1.27404953
57MP0008058_abnormal_DNA_repair1.26972354
58MP0005023_abnormal_wound_healing1.25309983
59MP0003984_embryonic_growth_retardation1.24494548
60MP0001730_embryonic_growth_arrest1.23759802
61MP0002638_abnormal_pupillary_reflex1.23178917
62MP0002398_abnormal_bone_marrow1.22199037
63* MP0002088_abnormal_embryonic_growth/wei1.22156019
64MP0003123_paternal_imprinting1.22019417
65MP0002254_reproductive_system_inflammat1.21767652
66MP0005380_embryogenesis_phenotype1.21176911
67MP0001672_abnormal_embryogenesis/_devel1.21176911
68MP0000703_abnormal_thymus_morphology1.19992138
69MP0004215_abnormal_myocardial_fiber1.18035380
70MP0000733_abnormal_muscle_development1.16500543
71MP0000613_abnormal_salivary_gland1.15744471
72MP0000465_gastrointestinal_hemorrhage1.14258099
73MP0002127_abnormal_cardiovascular_syste1.12176120
74MP0001915_intracranial_hemorrhage1.10513327
75MP0005671_abnormal_response_to1.08618509
76MP0009053_abnormal_anal_canal1.08279231
77MP0000383_abnormal_hair_follicle1.07341255
78MP0003252_abnormal_bile_duct1.07259540
79* MP0001697_abnormal_embryo_size1.07142074
80MP0001324_abnormal_eye_pigmentation1.06873570
81MP0006072_abnormal_retinal_apoptosis1.06770786
82MP0001800_abnormal_humoral_immune1.04773935
83MP0002084_abnormal_developmental_patter1.04587349
84MP0003279_aneurysm1.04327930
85MP0003121_genomic_imprinting1.04241523
86MP0003943_abnormal_hepatobiliary_system1.03477130
87MP0002452_abnormal_antigen_presenting1.03024568
88MP0001293_anophthalmia1.02796330
89MP0002722_abnormal_immune_system1.02570650
90MP0010678_abnormal_skin_adnexa1.02257357
91MP0000685_abnormal_immune_system1.01939252
92MP0005220_abnormal_exocrine_pancreas1.01633754
93MP0009333_abnormal_splenocyte_physiolog1.00975867
94MP0003436_decreased_susceptibility_to1.00341383
95MP0004134_abnormal_chest_morphology1.00177797
96MP0004084_abnormal_cardiac_muscle0.99932238
97MP0002163_abnormal_gland_morphology0.99332309
98MP0006292_abnormal_olfactory_placode0.99108764
99MP0001879_abnormal_lymphatic_vessel0.98593874
100MP0000689_abnormal_spleen_morphology0.98002428
101MP0004381_abnormal_hair_follicle0.96421271
102MP0005389_reproductive_system_phenotype0.96290764
103MP0003045_fibrosis0.95906962
104MP0004264_abnormal_extraembryonic_tissu0.95424442
105MP0010155_abnormal_intestine_physiology0.94591464
106* MP0002080_prenatal_lethality0.94151954
107MP0010030_abnormal_orbit_morphology0.93904917
108MP0003091_abnormal_cell_migration0.93798879
109MP0002085_abnormal_embryonic_tissue0.93670533
110MP0002925_abnormal_cardiovascular_devel0.93130380
111MP0002933_joint_inflammation0.92889361
112MP0002138_abnormal_hepatobiliary_system0.92802841
113MP0003890_abnormal_embryonic-extraembry0.92244790
114MP0000767_abnormal_smooth_muscle0.91933608
115MP0005395_other_phenotype0.91849857
116MP0002095_abnormal_skin_pigmentation0.91069426
117MP0002019_abnormal_tumor_incidence0.91011350
118MP0000716_abnormal_immune_system0.90965836
119MP0003448_altered_tumor_morphology0.90584611
120MP0002420_abnormal_adaptive_immunity0.90344096
121MP0005551_abnormal_eye_electrophysiolog0.90048336
122MP0009703_decreased_birth_body0.89769674
123MP0000749_muscle_degeneration0.88811424
124MP0001819_abnormal_immune_cell0.88613634
125MP0002060_abnormal_skin_morphology0.88257019
126MP0000371_diluted_coat_color0.87455125
127MP0002837_dystrophic_cardiac_calcinosis0.87202412
128MP0002160_abnormal_reproductive_system0.87104199
129MP0002429_abnormal_blood_cell0.86721450
130MP0002092_abnormal_eye_morphology0.85183119
131MP0001986_abnormal_taste_sensitivity0.84903446
132MP0001873_stomach_inflammation0.84756109
133MP0003935_abnormal_craniofacial_develop0.84485864
134MP0000516_abnormal_urinary_system0.84356768
135MP0005367_renal/urinary_system_phenotyp0.84356768
136MP0008775_abnormal_heart_ventricle0.83666974
137MP0000537_abnormal_urethra_morphology0.83665977
138MP0002108_abnormal_muscle_morphology0.83456536
139MP0009780_abnormal_chondrocyte_physiolo0.83377780
140MP0005508_abnormal_skeleton_morphology0.83180869
141MP0005646_abnormal_pituitary_gland0.82857174
142MP0000428_abnormal_craniofacial_morphol0.81527278
143MP0002075_abnormal_coat/hair_pigmentati0.81118455
144MP0003937_abnormal_limbs/digits/tail_de0.80714003
145MP0003828_pulmonary_edema0.80268408
146MP0000538_abnormal_urinary_bladder0.80196533
147MP0004947_skin_inflammation0.80096496
148MP0000313_abnormal_cell_death0.79068927
149MP0010368_abnormal_lymphatic_system0.78499140
150MP0001919_abnormal_reproductive_system0.78243104
151MP0002405_respiratory_system_inflammati0.78074165
152MP0000432_abnormal_head_morphology0.77719022
153MP0005647_abnormal_sex_gland0.74584980
154* MP0001119_abnormal_female_reproductive0.72498183
155MP0005379_endocrine/exocrine_gland_phen0.71889755
156MP0002282_abnormal_trachea_morphology0.71065640
157MP0000647_abnormal_sebaceous_gland0.69598127
158MP0005084_abnormal_gallbladder_morpholo0.69503600
159MP0001191_abnormal_skin_condition0.68556933
160MP0005266_abnormal_metabolism0.67672081
161MP0002928_abnormal_bile_duct0.67436094
162MP0004883_abnormal_blood_vessel0.65531538
163MP0008872_abnormal_physiological_respon0.65256000
164MP0004036_abnormal_muscle_relaxation0.64987048
165MP0000631_abnormal_neuroendocrine_gland0.61424337
166MP0005391_vision/eye_phenotype0.60750806
167MP0001186_pigmentation_phenotype0.60467515
168MP0000013_abnormal_adipose_tissue0.58629872
169MP0003718_maternal_effect0.55866260
170MP0004145_abnormal_muscle_electrophysio0.54707771
171MP0001177_atelectasis0.53588041

Predicted human phenotypes

RankGene SetZ-score
1Thyroiditis (HP:0100646)4.38753999
2Volvulus (HP:0002580)3.45153295
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.23430446
4Short 4th metacarpal (HP:0010044)3.23430446
5Aplasia/Hypoplasia of the fovea (HP:0008060)3.01832764
6Hypoplasia of the fovea (HP:0007750)3.01832764
7Abnormality of B cell number (HP:0010975)3.00561772
8Hypothermia (HP:0002045)2.99966609
9Absent frontal sinuses (HP:0002688)2.86761958
10B lymphocytopenia (HP:0010976)2.86112149
11Syringomyelia (HP:0003396)2.83939283
12Spinal cord lesions (HP:0100561)2.83939283
13Aqueductal stenosis (HP:0002410)2.83339690
14Abnormality of the fingertips (HP:0001211)2.78663332
15Pancreatic cysts (HP:0001737)2.77810044
16Intestinal atresia (HP:0011100)2.73579556
17Fair hair (HP:0002286)2.71082595
18Hematochezia (HP:0002573)2.70016933
19Albinism (HP:0001022)2.63880937
20Abnormality of the renal cortex (HP:0011035)2.60285163
21Aortic aneurysm (HP:0004942)2.56656410
22Abnormality of the fovea (HP:0000493)2.55496588
23Osteolytic defects of the hand bones (HP:0009699)2.51624307
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.51624307
25Long eyelashes (HP:0000527)2.49967334
26Protrusio acetabuli (HP:0003179)2.49949041
27Mesomelia (HP:0003027)2.46221360
28Stomach cancer (HP:0012126)2.41853595
29Severe combined immunodeficiency (HP:0004430)2.41671736
30Deep philtrum (HP:0002002)2.40391423
31Pancreatic fibrosis (HP:0100732)2.37435649
32Hypoplastic iliac wings (HP:0002866)2.36749706
33Asymmetry of the thorax (HP:0001555)2.36231685
34Renal cortical cysts (HP:0000803)2.35116057
35Neoplasm of the adrenal gland (HP:0100631)2.34559580
36Deviation of the thumb (HP:0009603)2.33541630
37Breast carcinoma (HP:0003002)2.32143346
38Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.31940846
39Acute myeloid leukemia (HP:0004808)2.31694260
40Hamartoma of the eye (HP:0010568)2.28331576
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26951320
42Papillary thyroid carcinoma (HP:0002895)2.26814037
43Abnormality of the nasal septum (HP:0000419)2.25455936
44Cutaneous melanoma (HP:0012056)2.24712132
45Chronic hepatic failure (HP:0100626)2.24445376
46Long clavicles (HP:0000890)2.24091226
47Ankle contracture (HP:0006466)2.23249434
48Glioma (HP:0009733)2.22236585
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.19451528
50Colon cancer (HP:0003003)2.19267412
51Thyroid carcinoma (HP:0002890)2.18170271
52Rhabdomyosarcoma (HP:0002859)2.17866434
53Chromsome breakage (HP:0040012)2.16321991
54Gaze-evoked nystagmus (HP:0000640)2.15606738
55True hermaphroditism (HP:0010459)2.15346919
56Progressive inability to walk (HP:0002505)2.14271989
57Abnormality of the 4th metacarpal (HP:0010012)2.13822747
58Abnormality of midbrain morphology (HP:0002418)2.13706844
59Molar tooth sign on MRI (HP:0002419)2.13706844
60Selective tooth agenesis (HP:0001592)2.13368433
61Abnormality of the astrocytes (HP:0100707)2.11384324
62Astrocytoma (HP:0009592)2.11384324
63Generalized hypopigmentation of hair (HP:0011358)2.11269001
64Proximal placement of thumb (HP:0009623)2.10753873
65Aplasia/Hypoplasia of the macula (HP:0008059)2.08208663
66Metaphyseal dysplasia (HP:0100255)2.08141735
67Pancreatic islet-cell hyperplasia (HP:0004510)2.07546581
68Rectal prolapse (HP:0002035)2.04225088
69Cerebral aneurysm (HP:0004944)2.03931620
70Hypoproteinemia (HP:0003075)2.03728317
71Small hand (HP:0200055)2.02774173
72Aortic dissection (HP:0002647)1.99040354
73Thrombocytosis (HP:0001894)1.98462362
74Aplasia/Hypoplasia of the tibia (HP:0005772)1.97837107
75Spondylolisthesis (HP:0003302)1.97591134
76Subacute progressive viral hepatitis (HP:0006572)1.94931671
77T lymphocytopenia (HP:0005403)1.94292266
78Sloping forehead (HP:0000340)1.94065265
79Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.93027276
80Abnormal foot bone ossification (HP:0010675)1.92368893
81Abnormality of the phalanges of the 2nd finger (HP:0009541)1.89046482
82Dilatation of the ascending aorta (HP:0005111)1.88832398
83Clubbing of toes (HP:0100760)1.87067543
84Disproportionate short-trunk short stature (HP:0003521)1.86411510
85Nephroblastoma (Wilms tumor) (HP:0002667)1.85848225
86Shallow orbits (HP:0000586)1.85427784
87Decreased skull ossification (HP:0004331)1.84199640
88Bifid tongue (HP:0010297)1.83893588
89Aplasia/Hypoplasia affecting the retina (HP:0008061)1.83717054
90Increased density of long bones (HP:0006392)1.83676392
91Cervical subluxation (HP:0003308)1.83601831
92Panhypogammaglobulinemia (HP:0003139)1.82822920
93Abnormal biliary tract morphology (HP:0012440)1.82678165
94Cutis marmorata (HP:0000965)1.82553449
95Abnormality of the frontal sinuses (HP:0002687)1.82257983
96Ependymoma (HP:0002888)1.81863459
97Biliary tract neoplasm (HP:0100574)1.81750625
98Facial diplegia (HP:0001349)1.81270161
99Bicuspid aortic valve (HP:0001647)1.80877360
100Embryonal renal neoplasm (HP:0011794)1.80833756
101Abnormality of eosinophils (HP:0001879)1.80740483
102Increased nuchal translucency (HP:0010880)1.80516392
103Abnormality of T cell number (HP:0011839)1.80260181
104Calf muscle hypertrophy (HP:0008981)1.79681890
105Aplasia/Hypoplasia of the tongue (HP:0010295)1.79350976
106Thin upper lip vermilion (HP:0000219)1.79236731
107Hypoplastic ischia (HP:0003175)1.78871837
108Limited elbow extension (HP:0001377)1.78223722
109Amaurosis fugax (HP:0100576)1.77698369
110Macroorchidism (HP:0000053)1.77347723
111Malignant gastrointestinal tract tumors (HP:0006749)1.76742958
112Gastrointestinal carcinoma (HP:0002672)1.76742958
113Autoimmune hemolytic anemia (HP:0001890)1.76647309
114Congenital stationary night blindness (HP:0007642)1.76541731
115Eosinophilia (HP:0001880)1.76493865
116Recurrent viral infections (HP:0004429)1.76096777
117Prominent nose (HP:0000448)1.75864546
118Birth length less than 3rd percentile (HP:0003561)1.75787853
119Thin bony cortex (HP:0002753)1.75711691
120Combined immunodeficiency (HP:0005387)1.75677034
121Urethral obstruction (HP:0000796)1.75459675
122Blue irides (HP:0000635)1.74793823
123Short tibia (HP:0005736)1.74497338
124Premature rupture of membranes (HP:0001788)1.73456115
125Mitral valve prolapse (HP:0001634)1.72297970
126Furrowed tongue (HP:0000221)1.71191465
127Hypoplastic labia majora (HP:0000059)1.70195045
128Attenuation of retinal blood vessels (HP:0007843)1.70194239
129Abnormality of aspartate family amino acid metabolism (HP:0010899)1.69776620
130Abnormality of the calcaneus (HP:0008364)1.69631020
131Meningioma (HP:0002858)1.69547135
13211 pairs of ribs (HP:0000878)1.69123774
133Dislocated radial head (HP:0003083)1.68721534
134Abnormality of vitamin B metabolism (HP:0004340)1.68683169
135Abnormality of the ileum (HP:0001549)1.68655711
136Abnormality of chromosome stability (HP:0003220)1.67552505
137Broad palm (HP:0001169)1.66444144
138Submucous cleft hard palate (HP:0000176)1.66422903
139Tongue fasciculations (HP:0001308)1.66402711
140High pitched voice (HP:0001620)1.65497686
141Broad face (HP:0000283)1.65055890
142Myelodysplasia (HP:0002863)1.64976411
143Conjunctival hamartoma (HP:0100780)1.64821230
144Increased number of teeth (HP:0011069)1.64585932
145Meckel diverticulum (HP:0002245)1.64382453
146Prostate neoplasm (HP:0100787)1.64232729
147Decreased central vision (HP:0007663)1.64053123
148Thoracolumbar scoliosis (HP:0002944)1.64045179
149Hypobetalipoproteinemia (HP:0003563)1.63811272
150Narrow palate (HP:0000189)1.63185811
151Persistence of primary teeth (HP:0006335)1.62468858
152IgM deficiency (HP:0002850)1.62413037
153Congenital sensorineural hearing impairment (HP:0008527)1.62410495
154Medulloblastoma (HP:0002885)1.62323261
155Stillbirth (HP:0003826)1.61878551
156Abnormality of the peritoneum (HP:0002585)1.61528271
157Radial bowing (HP:0002986)1.61496814
158Abnormality of the preputium (HP:0100587)1.61357731
159Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.60166874
160Wormian bones (HP:0002645)1.60041057
161Ectopic kidney (HP:0000086)1.59878491
162Abnormality of skull ossification (HP:0002703)1.59739261
163Neoplasm of the adrenal cortex (HP:0100641)1.59687526
164Abnormality of the renal medulla (HP:0100957)1.59199708
165Low anterior hairline (HP:0000294)1.58708950
166Abnormality of the radial head (HP:0003995)1.57189492
167Periodontitis (HP:0000704)1.56775447
168Spinal muscular atrophy (HP:0007269)1.55769743
169Abnormality of the anterior horn cell (HP:0006802)1.55127158
170Degeneration of anterior horn cells (HP:0002398)1.55127158
171Metaphyseal cupping (HP:0003021)1.54756306
172Abnormality of the ischium (HP:0003174)1.53060179
173Abnormal number of incisors (HP:0011064)1.52769508
174Exostoses (HP:0100777)1.51234005
175Short middle phalanx of the 5th finger (HP:0004220)1.50240947
176Abnormal platelet volume (HP:0011876)1.48943500
177Blepharitis (HP:0000498)1.48363712
178Bowel diverticulosis (HP:0005222)1.47716904
179Broad thumb (HP:0011304)1.47713355
180Truncal obesity (HP:0001956)1.47605050
181Facial hemangioma (HP:0000329)1.46801042
182Arterial tortuosity (HP:0005116)1.46708812
183Abnormality of the labia majora (HP:0012881)1.46626367
184Cellulitis (HP:0100658)1.46487804
185Skull defect (HP:0001362)1.45668221

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK3.30908195
2BMPR1B2.46120730
3TRIM282.33528745
4CDC72.33024799
5CDK122.19508605
6BRSK22.18945830
7LATS12.13271949
8FRK2.11111453
9STK102.08989696
10PKN22.05351515
11PDK22.02965916
12STK32.02344707
13MAP3K101.98422225
14NEK21.92358650
15STK391.85539188
16TNIK1.82285663
17MST41.82184859
18NLK1.81820270
19MKNK11.77780238
20NUAK11.65156438
21ZAK1.63889589
22FGFR31.62883855
23RPS6KA41.61979785
24STK38L1.60331106
25CDK61.59895208
26ACVR1B1.55926768
27BMPR21.48251718
28TTN1.44933383
29SRPK11.44468282
30MELK1.42650150
31PLK21.42284792
32AKT31.41200452
33SCYL21.38434615
34FLT31.37807920
35OBSCN1.37688513
36WEE11.36512309
37BRD41.36021895
38ERBB31.35848700
39EEF2K1.35412897
40JAK31.35059410
41WNK31.30985858
42OXSR11.30371777
43PIM11.27019641
44STK41.26742649
45ATR1.26107002
46MKNK21.24378968
47TGFBR21.24201376
48NEK91.23263647
49FER1.22565777
50MAP2K31.20863685
51MAP4K21.19259318
52CDK41.18445038
53RPS6KB21.15195522
54AURKB1.15114063
55PLK31.13373047
56TRIB31.13077488
57MAP3K141.12549652
58TGFBR11.12329698
59PTK61.12190667
60CHUK1.11400763
61MARK31.08824118
62MAP4K11.07626882
63PIK3CG1.07212343
64PAK31.03668415
65TYK21.03329119
66BUB11.00366454
67GRK10.99509934
68TEC0.98584748
69INSRR0.97791072
70BRSK10.97449341
71FGFR20.95302615
72LRRK20.95057564
73MAPK130.94909035
74IRAK10.92427409
75TAF10.92241169
76TTK0.91138883
77PLK10.90489098
78PAK40.90327913
79ZAP700.89275840
80SIK10.88100142
81CLK10.87686750
82CHEK10.86572736
83TRPM70.86126782
84CAMK1D0.85753195
85DYRK30.83761402
86SGK20.83579364
87MAP3K80.82340043
88IKBKB0.80007544
89ITK0.79637791
90ATM0.78749141
91TLK10.78544823
92TXK0.77244877
93FGFR10.77222601
94PDGFRA0.76879916
95PAK20.76732862
96CDK70.76644767
97STK240.76372417
98MAP3K20.76365196
99BCR0.75154249
100TAOK30.74816294
101JAK10.74577456
102CDK90.74039917
103VRK10.72584383
104CCNB10.72311052
105BTK0.71691812
106MAP3K30.71339348
107MTOR0.70027389
108EIF2AK30.69533530
109PNCK0.69026156
110CAMK1G0.68697625
111MAP3K120.68447319
112CSF1R0.68407339
113YES10.67108241
114EPHA40.66935081
115PDGFRB0.66779255
116CSNK1G10.66752805
117ADRBK20.66554597
118MUSK0.65481341
119CHEK20.64373270
120PTK2B0.63235835
121MAPKAPK30.61628261
122EIF2AK10.61179050
123HIPK20.60396687
124DDR20.60243248
125WNK40.59727864
126KIT0.59689185
127PINK10.59086628
128EIF2AK20.56587231
129SIK30.56210429
130CDK20.55023075
131PRKCE0.53429375
132DMPK0.52528396
133PRKAA20.51282687
134RPS6KA50.50141573
135TBK10.49969342
136DYRK1B0.49967383
137PLK40.49240492
138ALK0.48946038
139IRAK40.46830879
140IKBKE0.46589110
141SGK30.46182430
142PBK0.44213594
143CDK30.42273239
144MAPKAPK50.41324272
145CAMKK20.36529821
146NEK10.36098379
147RPS6KB10.33242764
148IRAK20.33192380
149ABL10.32271637
150PIK3CA0.31728019
151MAP3K40.30299833
152TSSK60.30235919
153GSK3A0.30052476

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.97888923
2Propanoate metabolism_Homo sapiens_hsa006402.88808641
3DNA replication_Homo sapiens_hsa030302.32226733
4Cell cycle_Homo sapiens_hsa041102.29816952
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27481381
6Mismatch repair_Homo sapiens_hsa034302.10852358
7Protein export_Homo sapiens_hsa030602.10427576
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.06752122
9Butanoate metabolism_Homo sapiens_hsa006501.99257847
10Systemic lupus erythematosus_Homo sapiens_hsa053221.94236111
11RNA transport_Homo sapiens_hsa030131.93241350
12Non-homologous end-joining_Homo sapiens_hsa034501.93114616
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91417459
14Spliceosome_Homo sapiens_hsa030401.86089593
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.80108229
16One carbon pool by folate_Homo sapiens_hsa006701.73334118
17Small cell lung cancer_Homo sapiens_hsa052221.71074748
18Antigen processing and presentation_Homo sapiens_hsa046121.66971699
19MicroRNAs in cancer_Homo sapiens_hsa052061.64880276
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.64602569
21Circadian rhythm_Homo sapiens_hsa047101.59934880
22Chronic myeloid leukemia_Homo sapiens_hsa052201.58189443
23Sulfur metabolism_Homo sapiens_hsa009201.58019852
24p53 signaling pathway_Homo sapiens_hsa041151.53124996
25Viral carcinogenesis_Homo sapiens_hsa052031.51897907
26Base excision repair_Homo sapiens_hsa034101.51076314
27Herpes simplex infection_Homo sapiens_hsa051681.50476216
28mRNA surveillance pathway_Homo sapiens_hsa030151.47325081
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.45168066
30Leishmaniasis_Homo sapiens_hsa051401.42347476
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.40007574
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37120725
33Steroid biosynthesis_Homo sapiens_hsa001001.36539570
34Fanconi anemia pathway_Homo sapiens_hsa034601.36316107
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36073581
36Measles_Homo sapiens_hsa051621.33753833
37Adherens junction_Homo sapiens_hsa045201.32353363
38Homologous recombination_Homo sapiens_hsa034401.29813596
39HTLV-I infection_Homo sapiens_hsa051661.29723462
40Proteasome_Homo sapiens_hsa030501.25773459
41Nucleotide excision repair_Homo sapiens_hsa034201.25353259
42RNA degradation_Homo sapiens_hsa030181.22865779
43Nitrogen metabolism_Homo sapiens_hsa009101.21290451
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20580540
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19168960
46Legionellosis_Homo sapiens_hsa051341.17474050
47Tryptophan metabolism_Homo sapiens_hsa003801.16063134
48Hepatitis B_Homo sapiens_hsa051611.15461033
49Primary immunodeficiency_Homo sapiens_hsa053401.14985729
50TGF-beta signaling pathway_Homo sapiens_hsa043501.13798142
51Toxoplasmosis_Homo sapiens_hsa051451.11807479
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11478075
53Focal adhesion_Homo sapiens_hsa045101.10083071
54Proteoglycans in cancer_Homo sapiens_hsa052051.10008671
55Colorectal cancer_Homo sapiens_hsa052101.09723561
56Caffeine metabolism_Homo sapiens_hsa002321.09712028
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09337345
58B cell receptor signaling pathway_Homo sapiens_hsa046621.07680405
59ECM-receptor interaction_Homo sapiens_hsa045121.07588850
60Pancreatic cancer_Homo sapiens_hsa052121.06346588
61Osteoclast differentiation_Homo sapiens_hsa043801.06117189
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05915937
63Ether lipid metabolism_Homo sapiens_hsa005651.02766562
64Hematopoietic cell lineage_Homo sapiens_hsa046401.02098886
65Leukocyte transendothelial migration_Homo sapiens_hsa046701.01758651
66Epstein-Barr virus infection_Homo sapiens_hsa051691.01746813
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00217113
68Prostate cancer_Homo sapiens_hsa052151.00151908
69Notch signaling pathway_Homo sapiens_hsa043300.99183105
70Viral myocarditis_Homo sapiens_hsa054160.98304104
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97467693
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97442898
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97425589
74Lysine degradation_Homo sapiens_hsa003100.96940506
75Apoptosis_Homo sapiens_hsa042100.96760068
76Platelet activation_Homo sapiens_hsa046110.94562712
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94207931
78mTOR signaling pathway_Homo sapiens_hsa041500.94020063
79Sphingolipid metabolism_Homo sapiens_hsa006000.92489332
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92472965
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.91473248
82TNF signaling pathway_Homo sapiens_hsa046680.91171358
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90682384
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.90054611
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90015163
86FoxO signaling pathway_Homo sapiens_hsa040680.89662581
87Influenza A_Homo sapiens_hsa051640.89592064
88T cell receptor signaling pathway_Homo sapiens_hsa046600.88989956
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88862724
90Fatty acid metabolism_Homo sapiens_hsa012120.86355301
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85427316
92Basal transcription factors_Homo sapiens_hsa030220.84476817
93Thyroid cancer_Homo sapiens_hsa052160.83271301
94Phototransduction_Homo sapiens_hsa047440.82694849
95Non-small cell lung cancer_Homo sapiens_hsa052230.81875977
96Hippo signaling pathway_Homo sapiens_hsa043900.81513933
97Acute myeloid leukemia_Homo sapiens_hsa052210.81314056
98Shigellosis_Homo sapiens_hsa051310.80956816
99Fatty acid degradation_Homo sapiens_hsa000710.80263974
100Regulation of autophagy_Homo sapiens_hsa041400.80109555
101Endometrial cancer_Homo sapiens_hsa052130.79234906
102Dorso-ventral axis formation_Homo sapiens_hsa043200.78954395
103N-Glycan biosynthesis_Homo sapiens_hsa005100.77635816
104Fatty acid elongation_Homo sapiens_hsa000620.76702482
105Selenocompound metabolism_Homo sapiens_hsa004500.75888121
106Pathways in cancer_Homo sapiens_hsa052000.75384406
107Linoleic acid metabolism_Homo sapiens_hsa005910.74453695
108Malaria_Homo sapiens_hsa051440.73502265
109RNA polymerase_Homo sapiens_hsa030200.72651195
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72360956
111Basal cell carcinoma_Homo sapiens_hsa052170.71728611
112Vitamin B6 metabolism_Homo sapiens_hsa007500.70966764
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70874882
114Peroxisome_Homo sapiens_hsa041460.68773172
115Alcoholism_Homo sapiens_hsa050340.67253863
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67168318
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64597367
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63811526
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.63540951
120Prolactin signaling pathway_Homo sapiens_hsa049170.63446497
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63229903
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63059474
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.61830020
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61377587
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61318073
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61272538
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60031890
128Renin-angiotensin system_Homo sapiens_hsa046140.59772067
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59397291
130Pertussis_Homo sapiens_hsa051330.59099390
131Inositol phosphate metabolism_Homo sapiens_hsa005620.58367068
132Purine metabolism_Homo sapiens_hsa002300.58219601
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57968052
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56763472
135Fatty acid biosynthesis_Homo sapiens_hsa000610.56728017
136Melanoma_Homo sapiens_hsa052180.55959887
137HIF-1 signaling pathway_Homo sapiens_hsa040660.54772243
138Type I diabetes mellitus_Homo sapiens_hsa049400.54479480
139Amoebiasis_Homo sapiens_hsa051460.53523157
140Insulin resistance_Homo sapiens_hsa049310.53244754
141Oocyte meiosis_Homo sapiens_hsa041140.53178348
142Renal cell carcinoma_Homo sapiens_hsa052110.51781408
143Chemokine signaling pathway_Homo sapiens_hsa040620.51526800
144Hepatitis C_Homo sapiens_hsa051600.51004176
145Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49302820
146Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48938026
147ABC transporters_Homo sapiens_hsa020100.47663314
148beta-Alanine metabolism_Homo sapiens_hsa004100.46122538
149Chemical carcinogenesis_Homo sapiens_hsa052040.44089605
150Glycerolipid metabolism_Homo sapiens_hsa005610.43880464
151Vitamin digestion and absorption_Homo sapiens_hsa049770.43521796
152Renin secretion_Homo sapiens_hsa049240.42838479
153Cysteine and methionine metabolism_Homo sapiens_hsa002700.41979396
154Mineral absorption_Homo sapiens_hsa049780.41924644
155Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40292828
156African trypanosomiasis_Homo sapiens_hsa051430.39864003
157Glucagon signaling pathway_Homo sapiens_hsa049220.38077366
158SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37059322
159cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33795148
160Complement and coagulation cascades_Homo sapiens_hsa046100.32834060

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