ZFY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of natural killer cell differentiation (GO:0032825)9.56130508
2positive regulation of interleukin-17 production (GO:0032740)7.05050377
3regulation of natural killer cell differentiation (GO:0032823)6.68076206
4positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)6.48367691
5positive regulation of interferon-gamma biosynthetic process (GO:0045078)5.74885154
6positive regulation of natural killer cell activation (GO:0032816)5.18949723
7regulation of interferon-gamma biosynthetic process (GO:0045072)5.10869062
8positive regulation of chemokine biosynthetic process (GO:0045080)4.97245769
9regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)4.96511656
10positive regulation of interleukin-10 production (GO:0032733)4.87632990
11negative regulation of T-helper cell differentiation (GO:0045623)4.73183563
12negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.73183563
13regulation of interleukin-17 production (GO:0032660)4.57857106
14CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.52923257
15positive regulation of natural killer cell mediated immunity (GO:0002717)4.48308960
16positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.45463884
17regulation of chemokine biosynthetic process (GO:0045073)4.29722010
18negative regulation of adaptive immune response (GO:0002820)4.10422603
19negative regulation of adaptive immune response based on somatic recombination of immune receptors b4.06259412
20positive regulation of B cell proliferation (GO:0030890)4.01847018
21regulation of natural killer cell activation (GO:0032814)3.94660178
22positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)3.93828546
23regulation of chronic inflammatory response (GO:0002676)3.92907366
24positive regulation of gamma-delta T cell activation (GO:0046645)3.78215793
25negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.75598143
26regulation of natural killer cell mediated immunity (GO:0002715)3.72415215
27regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.72415215
28defense response to protozoan (GO:0042832)3.71684542
29positive regulation of chemokine secretion (GO:0090197)3.63079702
30response to protozoan (GO:0001562)3.61023963
31response to interleukin-15 (GO:0070672)3.58561051
32regulation of MHC class II biosynthetic process (GO:0045346)3.54413273
33negative regulation of alpha-beta T cell differentiation (GO:0046639)3.49718784
34regulation of interleukin-10 production (GO:0032653)3.45559822
35positive regulation of cytokine production involved in immune response (GO:0002720)3.41065566
36positive regulation of cytokine biosynthetic process (GO:0042108)3.41058011
37negative regulation of cell killing (GO:0031342)3.40155234
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.40155234
39regulation of vitamin D biosynthetic process (GO:0060556)3.36310690
40cellular response to interleukin-15 (GO:0071350)3.35146096
41T-helper cell differentiation (GO:0042093)3.27255509
42CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.27255509
43regulation of isotype switching to IgG isotypes (GO:0048302)3.25614584
44seminiferous tubule development (GO:0072520)3.23741906
45positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.22157953
46histone H3-K36 demethylation (GO:0070544)3.21587564
47regulation of B cell proliferation (GO:0030888)3.19954600
48negative regulation of nitric oxide biosynthetic process (GO:0045019)3.17891980
49positive regulation of B cell activation (GO:0050871)3.15611443
50negative regulation of T cell mediated immunity (GO:0002710)3.11433082
51regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)3.11103837
52response to peptidoglycan (GO:0032494)3.10503106
53positive regulation of lymphocyte differentiation (GO:0045621)3.07602980
54regulation of chemokine secretion (GO:0090196)3.07008764
55positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.00399525
56regulation of isotype switching (GO:0045191)3.00243510
57positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.98153130
58regulation of B cell differentiation (GO:0045577)2.96361288
59positive regulation of production of molecular mediator of immune response (GO:0002702)2.96150326
60positive regulation of T cell differentiation in thymus (GO:0033089)2.95980288
61regulation of B cell activation (GO:0050864)2.93260683
62positive regulation of isotype switching (GO:0045830)2.86940094
63cellular response to ethanol (GO:0071361)2.84907404
64regulation of T-helper cell differentiation (GO:0045622)2.83831957
65regulation of leukocyte mediated cytotoxicity (GO:0001910)2.82805724
66positive regulation of tissue remodeling (GO:0034105)2.81425765
67negative regulation of B cell activation (GO:0050869)2.79968757
68T cell lineage commitment (GO:0002360)2.78555994
69positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.77107451
70T cell differentiation involved in immune response (GO:0002292)2.74690105
71alpha-beta T cell differentiation involved in immune response (GO:0002293)2.74690105
72alpha-beta T cell activation involved in immune response (GO:0002287)2.74690105
73regulation of vitamin metabolic process (GO:0030656)2.73187028
74regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.73128459
75Peyers patch development (GO:0048541)2.72639387
76mucosal-associated lymphoid tissue development (GO:0048537)2.72639387
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.70824579
78positive regulation of DNA recombination (GO:0045911)2.68169547
79natural killer cell differentiation (GO:0001779)2.66152456
80negative regulation of lymphocyte mediated immunity (GO:0002707)2.66087445
81positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.65282172
82production of molecular mediator of immune response (GO:0002440)2.64265493
83positive regulation of chemokine production (GO:0032722)2.63444863
84regulation of cytokine secretion involved in immune response (GO:0002739)2.62729393
85regulation of production of molecular mediator of immune response (GO:0002700)2.61901827
86T cell migration (GO:0072678)2.59666183
87negative regulation of alpha-beta T cell activation (GO:0046636)2.59604938
88regulation of thymocyte apoptotic process (GO:0070243)2.59019878
89positive regulation of interferon-gamma production (GO:0032729)2.57248174
90positive regulation of macrophage cytokine production (GO:0060907)2.55761963
91CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.55613926
92regulation of cytokine production involved in immune response (GO:0002718)2.54531073
93regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.49671400
94regulation of cell killing (GO:0031341)2.49509705
95negative regulation of interleukin-12 production (GO:0032695)2.49468418
96regulation of tyrosine phosphorylation of STAT protein (GO:0042509)2.49367226
97negative regulation of B cell mediated immunity (GO:0002713)2.49171452
98negative regulation of immunoglobulin mediated immune response (GO:0002890)2.49171452
99regulation of immunoglobulin production (GO:0002637)2.47447272
100positive regulation of B cell differentiation (GO:0045579)2.47266282

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.54615115
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.79304808
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.62581706
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.83606503
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.72377392
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.22242876
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.00619834
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.94398480
9RUNX_20019798_ChIP-Seq_JUKART_Human2.60694913
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.45699008
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40717203
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.30626534
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.22387558
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.16614302
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04385024
16GATA1_22025678_ChIP-Seq_K562_Human2.04230271
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01067771
18NOTCH1_21737748_ChIP-Seq_TLL_Human1.98733602
19VDR_24787735_ChIP-Seq_THP-1_Human1.94510027
20IGF1R_20145208_ChIP-Seq_DFB_Human1.92835689
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90712345
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80051985
23MYB_26560356_Chip-Seq_TH2_Human1.76335276
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73370514
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.73161306
26PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.71411696
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71388562
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67103375
29TAF15_26573619_Chip-Seq_HEK293_Human1.65290545
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60029378
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55996016
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55722078
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54293445
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54251976
35GATA3_26560356_Chip-Seq_TH2_Human1.49421523
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.43217612
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42513509
38SCL_19346495_ChIP-Seq_HPC-7_Human1.40925483
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40749803
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40393180
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39935364
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39833585
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36145028
44* P300_19829295_ChIP-Seq_ESCs_Human1.33488061
45GATA3_27048872_Chip-Seq_THYMUS_Human1.32159775
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27282812
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26567360
48VDR_22108803_ChIP-Seq_LS180_Human1.25674177
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24829105
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24829105
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23985152
52MYB_26560356_Chip-Seq_TH1_Human1.23068216
53ZNF274_21170338_ChIP-Seq_K562_Hela1.21963556
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21520804
55ER_23166858_ChIP-Seq_MCF-7_Human1.19292921
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18824882
57SPI1_23547873_ChIP-Seq_NB4_Human1.18548922
58GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17924153
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17610107
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16885126
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16748216
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15603110
63RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15432768
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13836856
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.12516757
66GBX2_23144817_ChIP-Seq_PC3_Human1.12031581
67CBP_20019798_ChIP-Seq_JUKART_Human1.09646713
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09646713
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09224044
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.08036813
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05150840
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05150840
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03198384
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00538834
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.00495187
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00129791
77SMAD4_21799915_ChIP-Seq_A2780_Human0.99896439
78BRD4_25478319_ChIP-Seq_HGPS_Human0.99642365
79SALL4_22934838_ChIP-ChIP_CD34+_Human0.99350803
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99154781
81NANOG_18555785_Chip-Seq_ESCs_Mouse0.98636630
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97576419
83NFE2_27457419_Chip-Seq_LIVER_Mouse0.96120161
84KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95903553
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95759921
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94099631
87E2F1_18555785_Chip-Seq_ESCs_Mouse0.94023991
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.93937340
89EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93907025
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91786882
91FLI1_21867929_ChIP-Seq_TH2_Mouse0.91402297
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91013824
93NMYC_18555785_Chip-Seq_ESCs_Mouse0.90460440
94STAT3_23295773_ChIP-Seq_U87_Human0.90185548
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89438832
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89207596
97EWS_26573619_Chip-Seq_HEK293_Human0.89115846
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.88791361
99TCF4_23295773_ChIP-Seq_U87_Human0.88749902
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88714627

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.56270109
2MP0006082_CNS_inflammation3.29920164
3MP0003724_increased_susceptibility_to3.21852580
4MP0006054_spinal_hemorrhage3.01915258
5MP0003303_peritoneal_inflammation2.77541309
6MP0005000_abnormal_immune_tolerance2.60133130
7MP0008004_abnormal_stomach_pH2.54953670
8MP0005387_immune_system_phenotype2.51123792
9MP0001790_abnormal_immune_system2.51123792
10MP0002148_abnormal_hypersensitivity_rea2.44335997
11MP0005310_abnormal_salivary_gland2.28281680
12MP0001873_stomach_inflammation2.24471904
13MP0005167_abnormal_blood-brain_barrier2.23928917
14MP0000685_abnormal_immune_system2.20490564
15MP0005671_abnormal_response_to2.19961045
16MP0003646_muscle_fatigue2.17779988
17MP0001800_abnormal_humoral_immune2.17498026
18MP0005397_hematopoietic_system_phenotyp2.10339592
19MP0001545_abnormal_hematopoietic_system2.10339592
20MP0002419_abnormal_innate_immunity2.09474732
21MP0003763_abnormal_thymus_physiology2.04555977
22MP0009840_abnormal_foam_cell2.04431190
23MP0002138_abnormal_hepatobiliary_system2.04052492
24MP0002452_abnormal_antigen_presenting2.03970399
25MP0003656_abnormal_erythrocyte_physiolo2.00071094
26MP0009764_decreased_sensitivity_to1.99721272
27MP0000465_gastrointestinal_hemorrhage1.98118041
28MP0003172_abnormal_lysosome_physiology1.97963639
29MP0002723_abnormal_immune_serum1.97893619
30MP0009785_altered_susceptibility_to1.97237132
31MP0003300_gastrointestinal_ulcer1.93717849
32MP0000569_abnormal_digit_pigmentation1.91411935
33MP0002166_altered_tumor_susceptibility1.91150881
34MP0005025_abnormal_response_to1.88622664
35MP0002420_abnormal_adaptive_immunity1.85948248
36MP0003436_decreased_susceptibility_to1.85072564
37MP0002006_tumorigenesis1.79796713
38MP0002254_reproductive_system_inflammat1.76300735
39MP0002009_preneoplasia1.75220813
40MP0001819_abnormal_immune_cell1.73474396
41MP0001348_abnormal_lacrimal_gland1.67622319
42MP0005464_abnormal_platelet_physiology1.63925729
43MP0002405_respiratory_system_inflammati1.63603876
44MP0002332_abnormal_exercise_endurance1.59555933
45MP0004742_abnormal_vestibular_system1.57334421
46MP0001845_abnormal_inflammatory_respons1.54472498
47MP0008469_abnormal_protein_level1.43510631
48MP0002139_abnormal_hepatobiliary_system1.41341260
49MP0002398_abnormal_bone_marrow1.39989326
50MP0005451_abnormal_body_composition1.39575336
51MP0005166_decreased_susceptibility_to1.34984623
52MP0003191_abnormal_cellular_cholesterol1.33977148
53MP0010155_abnormal_intestine_physiology1.33311853
54MP0000716_abnormal_immune_system1.30912203
55MP0002132_abnormal_respiratory_system1.30036101
56MP0000689_abnormal_spleen_morphology1.29036100
57MP0004036_abnormal_muscle_relaxation1.23898694
58MP0003252_abnormal_bile_duct1.23182503
59MP0000343_altered_response_to1.20423035
60MP0005174_abnormal_tail_pigmentation1.18981981
61MP0009278_abnormal_bone_marrow1.17760520
62MP0005410_abnormal_fertilization1.16489941
63MP0010386_abnormal_urinary_bladder1.07086628
64MP0000604_amyloidosis1.05797797
65MP0002998_abnormal_bone_remodeling1.05085491
66MP0004947_skin_inflammation1.04366883
67MP0002722_abnormal_immune_system1.02535132
68MP0001851_eye_inflammation1.02514561
69MP0001533_abnormal_skeleton_physiology0.98378964
70MP0005187_abnormal_penis_morphology0.96785406
71MP0002429_abnormal_blood_cell0.94716950
72MP0003868_abnormal_feces_composition0.92166637
73MP0004484_altered_response_of0.89465882
74MP0001915_intracranial_hemorrhage0.88982201
75MP0003690_abnormal_glial_cell0.88917382
76MP0010368_abnormal_lymphatic_system0.88210805
77MP0009333_abnormal_splenocyte_physiolog0.87129946
78MP0000015_abnormal_ear_pigmentation0.86036501
79MP0003828_pulmonary_edema0.84930058
80MP0001501_abnormal_sleep_pattern0.84817446
81MP0005647_abnormal_sex_gland0.79429684
82MP0001663_abnormal_digestive_system0.77776578
83MP0003448_altered_tumor_morphology0.77571414
84MP0005164_abnormal_response_to0.77455130
85MP0003221_abnormal_cardiomyocyte_apopto0.76805965
86MP0000249_abnormal_blood_vessel0.76586679
87MP0003195_calcinosis0.74755436
88MP0009379_abnormal_foot_pigmentation0.72531812
89MP0001986_abnormal_taste_sensitivity0.70504310
90MP0009763_increased_sensitivity_to0.70026848
91MP0008872_abnormal_physiological_respon0.69387885
92MP0009765_abnormal_xenobiotic_induced0.68492873
93MP0003011_delayed_dark_adaptation0.67975608
94MP0002736_abnormal_nociception_after0.67765569
95MP0005085_abnormal_gallbladder_physiolo0.66883806
96MP0001853_heart_inflammation0.66165553
97MP0003633_abnormal_nervous_system0.64884607
98MP0002396_abnormal_hematopoietic_system0.64577529
99MP0000920_abnormal_myelination0.64275095
100MP0003075_altered_response_to0.62674553

Predicted human phenotypes

RankGene SetZ-score
1Chronic diarrhea (HP:0002028)7.09161843
2Inflammation of the large intestine (HP:0002037)5.25267944
3Gastrointestinal inflammation (HP:0004386)4.89515664
4T lymphocytopenia (HP:0005403)3.97586549
5B lymphocytopenia (HP:0010976)3.88538426
6Thyroiditis (HP:0100646)3.80410491
7Abnormality of T cell number (HP:0011839)3.80075857
8Abnormality of B cell number (HP:0010975)3.69001382
9Gingival bleeding (HP:0000225)3.63777687
10Fatigue (HP:0012378)3.62035678
11Stomatitis (HP:0010280)3.57613075
12Abnormality of incisor morphology (HP:0011063)3.44231685
13Severe combined immunodeficiency (HP:0004430)3.24182518
14Disinhibition (HP:0000734)3.16291309
15Mediastinal lymphadenopathy (HP:0100721)3.11017557
16Leukocytosis (HP:0001974)3.09008357
17Hematochezia (HP:0002573)2.99008314
18Recurrent bacterial skin infections (HP:0005406)2.97873579
19Autoimmune thrombocytopenia (HP:0001973)2.92076018
20Abnormality of eosinophils (HP:0001879)2.91567772
21Prolonged bleeding time (HP:0003010)2.86521396
22Thrombocytosis (HP:0001894)2.84739028
23Autoimmune hemolytic anemia (HP:0001890)2.80200414
24Facial diplegia (HP:0001349)2.78931795
25Recurrent abscess formation (HP:0002722)2.69694705
26Curly hair (HP:0002212)2.67495338
27Abnormality of T cells (HP:0002843)2.65160505
28Combined immunodeficiency (HP:0005387)2.60486022
29Eosinophilia (HP:0001880)2.59844361
30Recurrent fungal infections (HP:0002841)2.57943954
31Neoplasm of the tracheobronchial system (HP:0100552)2.57867546
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.54783780
33Alveolar cell carcinoma (HP:0006519)2.52605691
34Bilateral sensorineural hearing impairment (HP:0008619)2.52392407
35Amaurosis fugax (HP:0100576)2.49597234
36Abnormality of liposaccharide metabolism (HP:0010968)2.45763317
37Abnormality of glycosphingolipid metabolism (HP:0004343)2.45763317
38Abnormality of glycolipid metabolism (HP:0010969)2.45763317
39Recurrent skin infections (HP:0001581)2.45417699
40Abnormality of the prostate (HP:0008775)2.45395772
41Epistaxis (HP:0000421)2.41699649
42Recurrent cutaneous fungal infections (HP:0011370)2.41161020
43Chronic mucocutaneous candidiasis (HP:0002728)2.41161020
44Myositis (HP:0100614)2.40909078
45Papilledema (HP:0001085)2.39803086
46Keratoconjunctivitis (HP:0001096)2.32921067
47Elevated erythrocyte sedimentation rate (HP:0003565)2.29364200
48Pulmonary infiltrates (HP:0002113)2.29338993
49Myocardial infarction (HP:0001658)2.28364253
50Chest pain (HP:0100749)2.25891052
51Keratoconjunctivitis sicca (HP:0001097)2.23575010
52Gastrointestinal infarctions (HP:0005244)2.22169569
53Arterial thrombosis (HP:0004420)2.19854270
54Prostate neoplasm (HP:0100787)2.16778480
55Retrobulbar optic neuritis (HP:0100654)2.15348465
56Optic neuritis (HP:0100653)2.15348465
57Long clavicles (HP:0000890)2.15020482
58Encephalitis (HP:0002383)2.14896728
59Renal cortical cysts (HP:0000803)2.13755673
60Recurrent viral infections (HP:0004429)2.12953033
61Mutism (HP:0002300)2.12809039
62Cystic hygroma (HP:0000476)2.12486020
63Metaphyseal dysplasia (HP:0100255)2.12220050
64Granulocytopenia (HP:0001913)2.10944660
65Recurrent gram-negative bacterial infections (HP:0005420)2.10781237
66Eczematoid dermatitis (HP:0000976)2.09754013
67Inappropriate behavior (HP:0000719)2.03959415
68Spontaneous abortion (HP:0005268)2.01266976
69Albinism (HP:0001022)2.00825557
70Megalencephaly (HP:0001355)2.00041682
71Thrombophlebitis (HP:0004418)1.99159474
72Flared iliac wings (HP:0002869)1.98782412
73Joint swelling (HP:0001386)1.97508781
74Increased CSF protein (HP:0002922)1.95034704
75Orchitis (HP:0100796)1.89911406
76Abnormality of macrophages (HP:0004311)1.84556545
77Fat malabsorption (HP:0002630)1.83971239
78Vasculitis (HP:0002633)1.82500113
79Clumsiness (HP:0002312)1.80150384
80Ulnar deviation of the wrist (HP:0003049)1.79903029
81Portal hypertension (HP:0001409)1.78936678
82Recurrent sinusitis (HP:0011108)1.78255168
83Panhypogammaglobulinemia (HP:0003139)1.76554512
84Progressive inability to walk (HP:0002505)1.75984269
85Azoospermia (HP:0000027)1.75681357
86Disproportionate short-trunk short stature (HP:0003521)1.74547416
87Abnormality of the axillary hair (HP:0100134)1.73168705
88Abnormality of secondary sexual hair (HP:0009888)1.73168705
89Abnormality of the periventricular white matter (HP:0002518)1.72832383
90Personality changes (HP:0000751)1.71400953
91Spontaneous hematomas (HP:0007420)1.70636252
92Abnormality of male internal genitalia (HP:0000022)1.70054941
93Increased IgM level (HP:0003496)1.68483098
94Peritonitis (HP:0002586)1.68079187
95Atonic seizures (HP:0010819)1.66624169
96Meningitis (HP:0001287)1.66609065
97Neutropenia (HP:0001875)1.65964683
98Pruritus (HP:0000989)1.65771771
99Steatorrhea (HP:0002570)1.65156693
100Abnormality of the distal phalanx of the thumb (HP:0009617)1.65110710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NLK2.57134887
2MAP3K122.54061473
3AKT32.36818862
4BMPR22.36314757
5CLK12.21319925
6ACVR1B2.20733899
7DYRK32.14288397
8BRD42.13596784
9EIF2AK32.11432439
10TXK2.08605451
11MAP3K142.05199274
12JAK11.84491527
13NEK91.73038326
14TAOK11.70958879
15TEC1.67578380
16TYK21.64636107
17MYLK1.53822004
18TIE11.49311363
19KSR21.46091381
20MAP4K11.43410579
21WNK31.43067470
22MAP3K41.41152363
23DDR21.40700534
24OBSCN1.38079762
25GRK71.37138374
26MAP2K71.32668208
27MARK31.31664570
28FRK1.31358718
29PRKAA21.31073773
30SGK21.30325721
31JAK31.28187177
32TNK21.27555494
33KSR11.27440411
34IKBKB1.23542493
35JAK21.21862717
36PAK61.20730180
37CSNK1G11.20007969
38TAOK31.19488064
39RAF11.16037907
40RIPK41.15549023
41FES1.15180764
42PIK3CG1.14133948
43HCK1.12961622
44PINK11.12049164
45ITK1.09874684
46ZAK1.09827876
47TGFBR21.06260629
48SCYL21.06027490
49KIT1.04462457
50MAP4K21.03805559
51ZAP701.03463550
52CSNK1A1L1.03431648
53TRPM71.00206726
54PAK30.99954753
55BTK0.94985973
56MAP3K50.94227144
57FGR0.93741876
58SGK4940.90781837
59SGK2230.90781837
60STK160.89130356
61BMPR1B0.87630309
62IKBKE0.86605026
63SYK0.85992914
64LYN0.81468359
65ADRBK20.80341810
66SGK30.79843799
67EPHA30.75990833
68CSNK1G30.75646760
69PIM10.75629558
70TBK10.74906924
71CAMKK20.74906105
72LCK0.74211992
73BLK0.74164462
74PIK3CA0.73284392
75CSNK1G20.72638359
76CSK0.65912923
77EIF2AK10.63992963
78MAP3K110.63790597
79CSF1R0.63222461
80CHUK0.59049145
81PRKCQ0.58087029
82ERBB30.57081180
83SGK10.56186309
84MAPK70.54266332
85MAP2K40.50575319
86CDC42BPA0.49386652
87MAPK110.47827935
88DYRK1B0.46557142
89PRKCE0.45858935
90MAP3K10.44550976
91MKNK20.44080154
92GSK3A0.43412047
93TRIM280.40664235
94PDGFRB0.40235616
95FER0.40008625
96PRKG10.38759840
97MATK0.37757970
98PKN10.37539988
99ABL10.36682338
100IRAK10.36518712

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.56226777
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.72108262
3Jak-STAT signaling pathway_Homo sapiens_hsa046302.64436335
4Allograft rejection_Homo sapiens_hsa053302.53119510
5Hematopoietic cell lineage_Homo sapiens_hsa046402.38635628
6Asthma_Homo sapiens_hsa053102.17953269
7Autoimmune thyroid disease_Homo sapiens_hsa053202.10964942
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.05448829
9Leishmaniasis_Homo sapiens_hsa051402.04878159
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.98196539
11NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91537085
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.89804467
13Measles_Homo sapiens_hsa051621.87555241
14Osteoclast differentiation_Homo sapiens_hsa043801.81192486
15T cell receptor signaling pathway_Homo sapiens_hsa046601.73437454
16Pertussis_Homo sapiens_hsa051331.72867330
17Graft-versus-host disease_Homo sapiens_hsa053321.69706022
18Staphylococcus aureus infection_Homo sapiens_hsa051501.69360263
19Primary immunodeficiency_Homo sapiens_hsa053401.69230601
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.68754669
21Malaria_Homo sapiens_hsa051441.64483521
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.64299372
23Legionellosis_Homo sapiens_hsa051341.62942828
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59382632
25Tuberculosis_Homo sapiens_hsa051521.54425072
26TNF signaling pathway_Homo sapiens_hsa046681.48434132
27Rheumatoid arthritis_Homo sapiens_hsa053231.45937968
28African trypanosomiasis_Homo sapiens_hsa051431.43571548
29Type I diabetes mellitus_Homo sapiens_hsa049401.40280651
30B cell receptor signaling pathway_Homo sapiens_hsa046621.39565898
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38807486
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.38210554
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36016077
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.30530440
35Influenza A_Homo sapiens_hsa051641.27997255
36Complement and coagulation cascades_Homo sapiens_hsa046101.22629532
37Herpes simplex infection_Homo sapiens_hsa051681.21265130
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15270435
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14587224
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14310795
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12072842
42Hepatitis B_Homo sapiens_hsa051611.06883517
43Regulation of autophagy_Homo sapiens_hsa041401.06276576
44Fatty acid biosynthesis_Homo sapiens_hsa000611.05618559
45Lysosome_Homo sapiens_hsa041421.04627093
46FoxO signaling pathway_Homo sapiens_hsa040681.02576790
47Acute myeloid leukemia_Homo sapiens_hsa052210.98305110
48Salmonella infection_Homo sapiens_hsa051320.95080497
49Circadian rhythm_Homo sapiens_hsa047100.91517400
50Prolactin signaling pathway_Homo sapiens_hsa049170.88130955
51Platelet activation_Homo sapiens_hsa046110.82423060
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80676109
53Chemokine signaling pathway_Homo sapiens_hsa040620.80147461
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79652553
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79635337
56Toxoplasmosis_Homo sapiens_hsa051450.78811178
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.78428187
58Apoptosis_Homo sapiens_hsa042100.76921824
59Olfactory transduction_Homo sapiens_hsa047400.75824564
60Peroxisome_Homo sapiens_hsa041460.74382995
61Shigellosis_Homo sapiens_hsa051310.70069035
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67188883
63Other glycan degradation_Homo sapiens_hsa005110.65300829
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63485472
65Phagosome_Homo sapiens_hsa041450.62473449
66Dorso-ventral axis formation_Homo sapiens_hsa043200.61275557
67Butanoate metabolism_Homo sapiens_hsa006500.60176936
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57080956
69Systemic lupus erythematosus_Homo sapiens_hsa053220.55001535
70Viral myocarditis_Homo sapiens_hsa054160.54863946
71Antigen processing and presentation_Homo sapiens_hsa046120.54532717
72PPAR signaling pathway_Homo sapiens_hsa033200.53585351
73Hepatitis C_Homo sapiens_hsa051600.52941448
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51120860
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.50927655
76Propanoate metabolism_Homo sapiens_hsa006400.50459240
77Prostate cancer_Homo sapiens_hsa052150.50085748
78Renin secretion_Homo sapiens_hsa049240.49279762
79Ether lipid metabolism_Homo sapiens_hsa005650.47277604
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46349830
81Chemical carcinogenesis_Homo sapiens_hsa052040.44812202
82Sphingolipid metabolism_Homo sapiens_hsa006000.43665763
83Insulin resistance_Homo sapiens_hsa049310.42923297
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41569349
85Tryptophan metabolism_Homo sapiens_hsa003800.41221746
86Colorectal cancer_Homo sapiens_hsa052100.40009124
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.39989635
88Amoebiasis_Homo sapiens_hsa051460.38456501
89Nitrogen metabolism_Homo sapiens_hsa009100.38207622
90Fatty acid degradation_Homo sapiens_hsa000710.37498550
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37331036
92Retinol metabolism_Homo sapiens_hsa008300.37303459
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37121018
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.35231184
95Renin-angiotensin system_Homo sapiens_hsa046140.34624940
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33490071
97MAPK signaling pathway_Homo sapiens_hsa040100.31215358
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31070247
99Pancreatic cancer_Homo sapiens_hsa052120.30723892
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.29952255

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