ZFYVE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.46760728
2L-phenylalanine catabolic process (GO:0006559)6.46760728
3L-phenylalanine metabolic process (GO:0006558)6.26032419
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.26032419
5aromatic amino acid family catabolic process (GO:0009074)5.80145647
6alpha-linolenic acid metabolic process (GO:0036109)5.78588818
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.54937562
8kynurenine metabolic process (GO:0070189)5.41013954
9urea metabolic process (GO:0019627)5.38616836
10urea cycle (GO:0000050)5.38616836
11bile acid biosynthetic process (GO:0006699)5.30197479
12indole-containing compound catabolic process (GO:0042436)5.23862256
13indolalkylamine catabolic process (GO:0046218)5.23862256
14tryptophan catabolic process (GO:0006569)5.23862256
15negative regulation of fibrinolysis (GO:0051918)5.18080613
16sulfur amino acid catabolic process (GO:0000098)5.14345043
17glyoxylate metabolic process (GO:0046487)5.12675213
18cysteine metabolic process (GO:0006534)4.99362410
19tryptophan metabolic process (GO:0006568)4.99104422
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.97661891
21nitrogen cycle metabolic process (GO:0071941)4.96269969
22regulation of protein activation cascade (GO:2000257)4.95735856
23complement activation, alternative pathway (GO:0006957)4.90993219
24serine family amino acid catabolic process (GO:0009071)4.90074628
25protein carboxylation (GO:0018214)4.85241147
26peptidyl-glutamic acid carboxylation (GO:0017187)4.85241147
27high-density lipoprotein particle remodeling (GO:0034375)4.77725913
28regulation of fibrinolysis (GO:0051917)4.73287945
29regulation of complement activation (GO:0030449)4.68595095
30lysine catabolic process (GO:0006554)4.66062025
31lysine metabolic process (GO:0006553)4.66062025
32bile acid metabolic process (GO:0008206)4.59620862
33homocysteine metabolic process (GO:0050667)4.56311993
34amino-acid betaine metabolic process (GO:0006577)4.41054316
35negative regulation of sterol transport (GO:0032372)4.36210804
36negative regulation of cholesterol transport (GO:0032375)4.36210804
37reverse cholesterol transport (GO:0043691)4.34173438
38regulation of triglyceride catabolic process (GO:0010896)4.32365045
39regulation of cholesterol homeostasis (GO:2000188)4.26186162
40aromatic amino acid family metabolic process (GO:0009072)4.24558386
41plasma lipoprotein particle clearance (GO:0034381)4.20460701
42alpha-amino acid catabolic process (GO:1901606)4.17854633
43tyrosine metabolic process (GO:0006570)4.16859854
44dicarboxylic acid biosynthetic process (GO:0043650)4.16009410
45regulation of cholesterol esterification (GO:0010872)4.10184735
46protein-lipid complex remodeling (GO:0034368)4.08523354
47macromolecular complex remodeling (GO:0034367)4.08523354
48plasma lipoprotein particle remodeling (GO:0034369)4.08523354
49protein localization to endosome (GO:0036010)4.06428333
50glycine metabolic process (GO:0006544)4.06011866
51triglyceride homeostasis (GO:0070328)4.05270142
52acylglycerol homeostasis (GO:0055090)4.05270142
53glutamate metabolic process (GO:0006536)4.01884426
54ethanol oxidation (GO:0006069)3.97580642
55phospholipid efflux (GO:0033700)3.97580132
56cellular modified amino acid catabolic process (GO:0042219)3.93858385
57cellular amino acid catabolic process (GO:0009063)3.90338564
58phospholipid homeostasis (GO:0055091)3.88101905
59positive regulation of fatty acid beta-oxidation (GO:0032000)3.86979161
60coenzyme catabolic process (GO:0009109)3.85615492
61serine family amino acid metabolic process (GO:0009069)3.84899085
62bile acid and bile salt transport (GO:0015721)3.84764989
63cholesterol efflux (GO:0033344)3.80236928
64acetyl-CoA metabolic process (GO:0006084)3.77047826
65plasma lipoprotein particle assembly (GO:0034377)3.76072061
66positive regulation of lipid catabolic process (GO:0050996)3.73678474
67drug catabolic process (GO:0042737)3.70267328
68imidazole-containing compound metabolic process (GO:0052803)3.69405677
69regulation of fatty acid beta-oxidation (GO:0031998)3.65881351
70indolalkylamine metabolic process (GO:0006586)3.61656886
712-oxoglutarate metabolic process (GO:0006103)3.61621801
72protein-lipid complex assembly (GO:0065005)3.59126158
73cellular glucuronidation (GO:0052695)3.58437787
74positive regulation of triglyceride lipase activity (GO:0061365)3.58364955
75positive regulation of lipoprotein lipase activity (GO:0051006)3.58364955
76aspartate family amino acid catabolic process (GO:0009068)3.56894374
77benzene-containing compound metabolic process (GO:0042537)3.53586060
78cholesterol homeostasis (GO:0042632)3.50583805
79cellular ketone body metabolic process (GO:0046950)3.50105373
80serine family amino acid biosynthetic process (GO:0009070)3.49952442
81sterol homeostasis (GO:0055092)3.46461124
82barbed-end actin filament capping (GO:0051016)3.44566870
83arginine metabolic process (GO:0006525)3.43276432
84very-low-density lipoprotein particle assembly (GO:0034379)3.40174293
85short-chain fatty acid metabolic process (GO:0046459)3.39217230
86cellular biogenic amine catabolic process (GO:0042402)3.38252003
87amine catabolic process (GO:0009310)3.38252003
88complement activation, classical pathway (GO:0006958)3.37568022
89heme transport (GO:0015886)3.37125937
90carboxylic acid catabolic process (GO:0046395)3.36291884
91organic acid catabolic process (GO:0016054)3.36291884
92epoxygenase P450 pathway (GO:0019373)3.34950365
93fibrinolysis (GO:0042730)3.34449879
94regulation of bile acid biosynthetic process (GO:0070857)3.34333822
95lipoprotein metabolic process (GO:0042157)3.33420865
96complement activation (GO:0006956)3.29476947
97valine metabolic process (GO:0006573)3.27196082
98low-density lipoprotein particle remodeling (GO:0034374)3.23729569
99cytolysis (GO:0019835)3.22929409
100plasma lipoprotein particle organization (GO:0071827)3.21649638
101exogenous drug catabolic process (GO:0042738)3.20404232
102negative regulation of lipase activity (GO:0060192)3.20180044
103stress fiber assembly (GO:0043149)3.03384043
104positive regulation by symbiont of host defense response (GO:0052509)2.98536243
105modulation by symbiont of host defense response (GO:0052031)2.98536243
106modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.98536243
107modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.98536243
108positive regulation by organism of defense response of other organism involved in symbiotic interact2.98536243
109modulation by symbiont of host immune response (GO:0052553)2.98536243
110amino sugar catabolic process (GO:0046348)2.89192638
111negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.87172898
112autophagic vacuole assembly (GO:0000045)2.79786384
113response to muramyl dipeptide (GO:0032495)2.77125369
114amyloid precursor protein catabolic process (GO:0042987)2.67065715
115detection of molecule of bacterial origin (GO:0032490)2.66873254
116neutrophil activation involved in immune response (GO:0002283)2.66423143
117negative regulation of erythrocyte differentiation (GO:0045647)2.66256608
118response to peptidoglycan (GO:0032494)2.66096135
119response to laminar fluid shear stress (GO:0034616)2.61846800
120Golgi transport vesicle coating (GO:0048200)2.60419601
121COPI coating of Golgi vesicle (GO:0048205)2.60419601
122regulation of early endosome to late endosome transport (GO:2000641)2.58729932
123positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.54474185
124skin morphogenesis (GO:0043589)2.52239098
125NIK/NF-kappaB signaling (GO:0038061)2.48895578
126macrophage activation involved in immune response (GO:0002281)2.48136153
127negative regulation of cell killing (GO:0031342)2.47321579
128negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.47321579
129positive regulation of Cdc42 GTPase activity (GO:0043089)2.45578066
130regulation of ARF protein signal transduction (GO:0032012)2.44397589
131regulation of T-helper 2 cell differentiation (GO:0045628)2.43853486
132positive regulation of receptor recycling (GO:0001921)2.41917932
133cellular response to nerve growth factor stimulus (GO:1990090)2.37634569
134response to nerve growth factor (GO:1990089)2.37634569
135substrate-dependent cell migration (GO:0006929)2.35167252
136positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.32483921
137regulation of leukocyte degranulation (GO:0043300)2.31805826
138macroautophagy (GO:0016236)2.30795794
139positive regulation of cholesterol efflux (GO:0010875)2.29195807
140cellular response to arsenic-containing substance (GO:0071243)2.27662400
141negative regulation of interleukin-12 production (GO:0032695)2.26387871
142granulocyte activation (GO:0036230)2.26368060
143detection of other organism (GO:0098543)2.25915089
144regulation of retinoic acid receptor signaling pathway (GO:0048385)2.25233352
145signal complex assembly (GO:0007172)2.22273834
146viral protein processing (GO:0019082)2.21966410
147endocytic recycling (GO:0032456)2.21224040
148negative regulation of cAMP-mediated signaling (GO:0043951)2.20428394
149detection of external biotic stimulus (GO:0098581)2.19218173
150vacuole organization (GO:0007033)2.19142901
151positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.17279119
152negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.16318539
153lipopolysaccharide-mediated signaling pathway (GO:0031663)2.16085068
154endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.15910669
155positive regulation of fibroblast migration (GO:0010763)2.15216529
156low-density lipoprotein particle clearance (GO:0034383)2.14215872
157membrane invagination (GO:0010324)2.13448567
158cell adhesion mediated by integrin (GO:0033627)2.11892890
159germinal center formation (GO:0002467)2.11201767
160positive regulation of p38MAPK cascade (GO:1900745)2.09047888
161negative regulation of glial cell proliferation (GO:0060253)2.08394865
162regulation of mast cell degranulation (GO:0043304)2.07864003
163mannose metabolic process (GO:0006013)2.07042698
164positive regulation of blood vessel endothelial cell migration (GO:0043536)2.06994444
165hemoglobin metabolic process (GO:0020027)2.06238232
166protein targeting to plasma membrane (GO:0072661)2.06111318
167detection of bacterium (GO:0016045)2.05851721
168regulation of regulated secretory pathway (GO:1903305)2.05817840
169regulation of macrophage cytokine production (GO:0010935)2.03399490
170positive regulation of protein homooligomerization (GO:0032464)2.03034077
171semaphorin-plexin signaling pathway (GO:0071526)2.02298210
172nerve growth factor signaling pathway (GO:0038180)2.02173107
173neutrophil activation (GO:0042119)2.01826597
174positive regulation of leukocyte degranulation (GO:0043302)2.00733776
175positive regulation of cellular amide metabolic process (GO:0034250)2.00537998
176mitochondrion degradation (GO:0000422)2.00226420
177hyaluronan catabolic process (GO:0030214)1.99885584
178retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)1.98787025
179regulation of myeloid leukocyte mediated immunity (GO:0002886)1.98031643
180cytoskeletal anchoring at plasma membrane (GO:0007016)1.97979142
181negative regulation of glycoprotein metabolic process (GO:1903019)1.97938279
182negative regulation of glycoprotein biosynthetic process (GO:0010561)1.97875008
183positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)1.97573925
184negative regulation of protein localization to plasma membrane (GO:1903077)1.95565561
185protein retention in ER lumen (GO:0006621)1.94683186
186regulation of necroptotic process (GO:0060544)1.94344474
187receptor recycling (GO:0001881)1.93903475
188basement membrane organization (GO:0071711)1.93192971
189regulation of Rho protein signal transduction (GO:0035023)1.92509778
190vascular endothelial growth factor receptor signaling pathway (GO:0048010)1.91768813
191amyloid precursor protein metabolic process (GO:0042982)1.91422735
192maintenance of protein localization in endoplasmic reticulum (GO:0035437)1.91360234
193regulation of mast cell activation involved in immune response (GO:0033006)1.90832260
194regulation of membrane protein ectodomain proteolysis (GO:0051043)1.90791981
195activation of MAPKKK activity (GO:0000185)1.90747676
196fibril organization (GO:0097435)1.89339713
197regulation of cholesterol storage (GO:0010885)1.88587990
198peptide catabolic process (GO:0043171)1.88285754
199type B pancreatic cell proliferation (GO:0044342)1.87407323
200virion assembly (GO:0019068)1.87366425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.66731160
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.99683670
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.15228906
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.63503651
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.85751196
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.37751449
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.22156731
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.76022664
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.29167415
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.69112301
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.34643015
12CLOCK_20551151_ChIP-Seq_293T_Human2.10513227
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09888202
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05386077
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97598060
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.92309573
17EGR1_19374776_ChIP-ChIP_THP-1_Human1.89463004
18FOXA2_19822575_ChIP-Seq_HepG2_Human1.88933403
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.87272442
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82537924
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.82315909
22GATA1_19941827_ChIP-Seq_MEL_Mouse1.76092475
23VDR_21846776_ChIP-Seq_THP-1_Human1.72914973
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70996505
25GATA2_21666600_ChIP-Seq_HMVEC_Human1.66615930
26ZNF263_19887448_ChIP-Seq_K562_Human1.62304140
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58959912
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58357899
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.57969740
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57202384
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54755452
32* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.53866635
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.48289418
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47928147
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46487378
36SPI1_23127762_ChIP-Seq_K562_Human1.43647726
37* HNF4A_19822575_ChIP-Seq_HepG2_Human1.43112160
38VDR_24763502_ChIP-Seq_THP-1_Human1.42338123
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.41709458
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40554102
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39958261
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38099841
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36072773
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31062073
45* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30689285
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29199401
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.27492615
48* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26471630
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26249265
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25863086
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24361397
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23663980
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.22865060
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21401453
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21120434
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20475847
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.18371711
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17916367
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17037677
60LXR_22292898_ChIP-Seq_THP-1_Human1.16340530
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16017499
62* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14453633
63SCL_19346495_ChIP-Seq_HPC-7_Human1.13892702
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13163217
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10810353
66FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10218913
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09997227
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.09421097
69IRF8_21731497_ChIP-ChIP_J774_Mouse1.09368130
70TP53_22127205_ChIP-Seq_IMR90_Human1.07564127
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.02901605
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01847235
73MAF_26560356_Chip-Seq_TH1_Human1.01660661
74VDR_24787735_ChIP-Seq_THP-1_Human1.01327027
75UTX_26944678_Chip-Seq_JUKART_Human1.01185165
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00591963
77GATA1_22025678_ChIP-Seq_K562_Human1.00237164
78SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99943016
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99676901
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99354379
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98537140
82* TET1_21490601_ChIP-Seq_MESCs_Mouse0.98390437
83RACK7_27058665_Chip-Seq_MCF-7_Human0.98308042
84TFEB_21752829_ChIP-Seq_HELA_Human0.98052506
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97900906
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97161031
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97140442
88HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96758163
89GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95341811
90STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94617315
91P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93734062
92MAF_26560356_Chip-Seq_TH2_Human0.93640847
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93250322
94SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92738939
95TRIM28_21343339_ChIP-Seq_HEK293_Human0.91972292
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90764551
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90278256
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90122834
99ESR1_21235772_ChIP-Seq_MCF-7_Human0.89961289
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89552329
101NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88945961
102PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87323943
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87215338
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87211826
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86982942
106RARA_24833708_ChIP-Seq_LIVER_Mouse0.86759053
107CREB1_26743006_Chip-Seq_LNCaP_Human0.86228050
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85837839
109* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85143579
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84375786
111KDM2B_26808549_Chip-Seq_K562_Human0.84360973
112KDM2B_26808549_Chip-Seq_DND41_Human0.84039991
113MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83975939
114GATA1_19941826_ChIP-Seq_K562_Human0.81815991
115GATA4_25053715_ChIP-Seq_YYC3_Human0.80384564
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79982178
117* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79477649
118GATA6_25053715_ChIP-Seq_YYC3_Human0.79023731
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.78770933
120NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78674537
121ELK3_25401928_ChIP-Seq_HUVEC_Human0.78593684
122* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.78504390
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78343003
124EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78068442
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77968293
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77550130
127KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77393894
128* TBX20_22080862_ChIP-Seq_HEART_Mouse0.76143041
129* TBX20_22328084_ChIP-Seq_HEART_Mouse0.76143041
130RARB_24833708_ChIP-Seq_LIVER_Mouse0.75989710
131RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.75599573
132TCF7_22412390_ChIP-Seq_EML_Mouse0.74811660
133Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73287989
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.71723454
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.71610731
136ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71535897
137KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.71508849
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71151793
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.70768261
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.70588062
141ATF3_27146783_Chip-Seq_COLON_Human0.70160170
142SMC4_20622854_ChIP-Seq_HELA_Human0.67806806
143POU5F1_16518401_ChIP-PET_MESCs_Mouse0.65652679
144FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.65500153
145P68_20966046_ChIP-Seq_HELA_Human0.65364996
146ZFP281_27345836_Chip-Seq_ESCs_Mouse0.65293814
147SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.64078726
148BCOR_27268052_Chip-Seq_Bcells_Human0.63322683
149FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.63098277
150* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.62500292
151NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.61797321
152HTT_18923047_ChIP-ChIP_STHdh_Human0.61121477
153FOXA1_25552417_ChIP-Seq_VCAP_Human0.60642183
154MYC_27129775_Chip-Seq_CORNEA_Mouse0.60572936
155KLF4_19829295_ChIP-Seq_ESCs_Human0.60033031
156RUNX1_27514584_Chip-Seq_MCF-7_Human0.59720345
157GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.59154914
158TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.58046961
159STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.57970991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.75216342
2MP0005360_urolithiasis7.10290567
3MP0005085_abnormal_gallbladder_physiolo5.92985579
4MP0005365_abnormal_bile_salt5.87302385
5MP0008875_abnormal_xenobiotic_pharmacok4.32114613
6MP0003252_abnormal_bile_duct3.95839139
7MP0003806_abnormal_nucleotide_metabolis3.68129248
8MP0009840_abnormal_foam_cell3.60835468
9MP0010329_abnormal_lipoprotein_level3.56598026
10MP0008260_abnormal_autophagy3.47218367
11MP0003303_peritoneal_inflammation3.39558221
12MP0005332_abnormal_amino_acid2.62378164
13MP0003705_abnormal_hypodermis_morpholog2.60239506
14MP0005083_abnormal_biliary_tract2.59535887
15MP0004510_myositis2.58918070
16MP0003724_increased_susceptibility_to2.39533477
17MP0001666_abnormal_nutrient_absorption2.34553809
18MP0003191_abnormal_cellular_cholesterol2.33479271
19MP0003436_decreased_susceptibility_to2.26620955
20MP0000609_abnormal_liver_physiology2.20374141
21MP0003279_aneurysm2.20111262
22MP0003195_calcinosis2.10481637
23MP0002118_abnormal_lipid_homeostasis2.08709509
24MP0004019_abnormal_vitamin_homeostasis1.98811754
25MP0002877_abnormal_melanocyte_morpholog1.86519345
26MP0000015_abnormal_ear_pigmentation1.85216090
27MP0004233_abnormal_muscle_weight1.84613864
28MP0000751_myopathy1.84099000
29MP0005319_abnormal_enzyme/_coenzyme1.80685581
30MP0001958_emphysema1.73045851
31MP0003091_abnormal_cell_migration1.68229882
32MP0003828_pulmonary_edema1.66792486
33MP0002138_abnormal_hepatobiliary_system1.62931716
34MP0005275_abnormal_skin_tensile1.62765388
35MP0003183_abnormal_peptide_metabolism1.62645658
36MP0005257_abnormal_intraocular_pressure1.59417926
37MP0009278_abnormal_bone_marrow1.52527107
38MP0003868_abnormal_feces_composition1.52069094
39MP0002332_abnormal_exercise_endurance1.50957230
40MP0006054_spinal_hemorrhage1.50497061
41MP0001533_abnormal_skeleton_physiology1.48077483
42MP0005670_abnormal_white_adipose1.47599392
43MP0002998_abnormal_bone_remodeling1.44220357
44MP0000604_amyloidosis1.43556224
45MP0002419_abnormal_innate_immunity1.41527056
46MP0000750_abnormal_muscle_regeneration1.38980627
47MP0000343_altered_response_to1.37413054
48MP0005584_abnormal_enzyme/coenzyme_acti1.35719249
49MP0002254_reproductive_system_inflammat1.34796289
50MP0003221_abnormal_cardiomyocyte_apopto1.30831111
51MP0001542_abnormal_bone_strength1.27532671
52MP0009643_abnormal_urine_homeostasis1.24698757
53MP0004130_abnormal_muscle_cell1.24242466
54MP0006082_CNS_inflammation1.23750802
55MP0000598_abnormal_liver_morphology1.21470064
56MP0005464_abnormal_platelet_physiology1.17504299
57MP0002148_abnormal_hypersensitivity_rea1.17013722
58MP0003656_abnormal_erythrocyte_physiolo1.16161201
59MP0004947_skin_inflammation1.14202734
60MP0000759_abnormal_skeletal_muscle1.13007047
61MP0005397_hematopoietic_system_phenotyp1.12924409
62MP0001545_abnormal_hematopoietic_system1.12924409
63MP0000920_abnormal_myelination1.12791351
64MP0001764_abnormal_homeostasis1.10963732
65MP0005025_abnormal_response_to1.10558791
66MP0003329_amyloid_beta_deposits1.10024985
67MP0005451_abnormal_body_composition1.08355233
68MP0000733_abnormal_muscle_development1.08251862
69MP0005171_absent_coat_pigmentation1.07074854
70MP0009785_altered_susceptibility_to1.06224546
71MP0004272_abnormal_basement_membrane1.06091255
72MP0000767_abnormal_smooth_muscle1.05264730
73MP0004381_abnormal_hair_follicle1.04449531
74MP0005647_abnormal_sex_gland1.03759287
75MP0002295_abnormal_pulmonary_circulatio1.01916424
76MP0005000_abnormal_immune_tolerance1.01563021
77MP0005666_abnormal_adipose_tissue1.01328604
78MP0000749_muscle_degeneration0.99807381
79MP0005390_skeleton_phenotype0.98573853
80MP0008004_abnormal_stomach_pH0.96900516
81MP0005058_abnormal_lysosome_morphology0.92625605
82MP0005409_darkened_coat_color0.92152317
83MP0003690_abnormal_glial_cell0.92061739
84MP0001986_abnormal_taste_sensitivity0.87760066
85MP0002971_abnormal_brown_adipose0.85169001
86MP0000858_altered_metastatic_potential0.84716692
87MP0009053_abnormal_anal_canal0.82581245
88MP0002896_abnormal_bone_mineralization0.82410270
89MP0008438_abnormal_cutaneous_collagen0.82076791
90MP0003634_abnormal_glial_cell0.82039330
91MP0003011_delayed_dark_adaptation0.81630770
92MP0001661_extended_life_span0.81260992
93MP0003300_gastrointestinal_ulcer0.80504058
94MP0004185_abnormal_adipocyte_glucose0.80470797
95MP0001756_abnormal_urination0.79709359
96MP0002078_abnormal_glucose_homeostasis0.79411415
97MP0005503_abnormal_tendon_morphology0.79202304
98MP0009763_increased_sensitivity_to0.79030576
99MP0010234_abnormal_vibrissa_follicle0.79018955
100MP0001790_abnormal_immune_system0.78201996
101MP0005387_immune_system_phenotype0.78201996
102MP0004859_abnormal_synaptic_plasticity0.77008949
103MP0003186_abnormal_redox_activity0.76409460
104MP0009642_abnormal_blood_homeostasis0.76095482
105MP0003879_abnormal_hair_cell0.76006877
106MP0008961_abnormal_basal_metabolism0.74967051
107MP0009764_decreased_sensitivity_to0.74709324
108MP0002060_abnormal_skin_morphology0.74414474
109MP0005334_abnormal_fat_pad0.73466674
110MP0002269_muscular_atrophy0.72610571
111MP0005508_abnormal_skeleton_morphology0.69928415
112MP0005164_abnormal_response_to0.69926502
113MP0009697_abnormal_copulation0.69757723
114MP0003448_altered_tumor_morphology0.69639848
115MP0001835_abnormal_antigen_presentation0.69414821
116MP0009333_abnormal_splenocyte_physiolog0.68486249
117MP0004087_abnormal_muscle_fiber0.68398960
118MP0002452_abnormal_antigen_presenting0.68081455
119MP0000685_abnormal_immune_system0.67489604
120MP0010386_abnormal_urinary_bladder0.67399765
121MP0005621_abnormal_cell_physiology0.67152323
122MP0003795_abnormal_bone_structure0.66915783
123MP0005636_abnormal_mineral_homeostasis0.66777197
124MP0009765_abnormal_xenobiotic_induced0.65270461
125MP0005410_abnormal_fertilization0.65224765
126MP0003566_abnormal_cell_adhesion0.61813007
127MP0008469_abnormal_protein_level0.59548155
128MP0005248_abnormal_Harderian_gland0.59266151
129MP0002168_other_aberrant_phenotype0.58507821
130MP0005408_hypopigmentation0.58162410
131MP0004858_abnormal_nervous_system0.58161434
132MP0004264_abnormal_extraembryonic_tissu0.58147809
133MP0005376_homeostasis/metabolism_phenot0.58048337
134MP0005375_adipose_tissue_phenotype0.57738962
135MP0009672_abnormal_birth_weight0.57379239
136MP0005023_abnormal_wound_healing0.55990125
137MP0005266_abnormal_metabolism0.55929213
138MP0001849_ear_inflammation0.55560092
139MP0005535_abnormal_body_temperature0.55228134
140MP0003172_abnormal_lysosome_physiology0.55127615
141MP0005448_abnormal_energy_balance0.53963785
142MP0001915_intracranial_hemorrhage0.53758134
143MP0002136_abnormal_kidney_physiology0.52602613
144MP0000639_abnormal_adrenal_gland0.52125531
145MP0009115_abnormal_fat_cell0.51545016
146MP0002928_abnormal_bile_duct0.48914585
147MP0010368_abnormal_lymphatic_system0.48859653
148MP0008874_decreased_physiological_sensi0.47212558
149MP0005076_abnormal_cell_differentiation0.46458477
150MP0005167_abnormal_blood-brain_barrier0.45817661
151MP0005395_other_phenotype0.45289552
152MP0003075_altered_response_to0.44411492
153MP0002653_abnormal_ependyma_morphology0.43677477
154MP0002970_abnormal_white_adipose0.43254545
155MP0003453_abnormal_keratinocyte_physiol0.42644248
156MP0009384_cardiac_valve_regurgitation0.42038280
157MP0002837_dystrophic_cardiac_calcinosis0.41655163
158MP0003953_abnormal_hormone_level0.40504608
159MP0005187_abnormal_penis_morphology0.40234429
160MP0002822_catalepsy0.39095898
161MP0010352_gastrointestinal_tract_polyps0.37906193
162MP0006036_abnormal_mitochondrial_physio0.36928364
163MP0003283_abnormal_digestive_organ0.36221911
164MP0001881_abnormal_mammary_gland0.35509471
165MP0009780_abnormal_chondrocyte_physiolo0.35322020
166MP0000371_diluted_coat_color0.34430204
167MP0003632_abnormal_nervous_system0.33919198
168MP0000747_muscle_weakness0.33788696

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.77211357
2Intrahepatic cholestasis (HP:0001406)6.60841917
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.92944889
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.89026680
5Xanthomatosis (HP:0000991)5.83683840
6Hypobetalipoproteinemia (HP:0003563)5.31353657
7Complement deficiency (HP:0004431)4.99008256
8Hyperlipoproteinemia (HP:0010980)4.89125176
9Prolonged partial thromboplastin time (HP:0003645)4.81176596
10Abnormality of glycolipid metabolism (HP:0010969)4.26754547
11Abnormality of liposaccharide metabolism (HP:0010968)4.26754547
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.26754547
13Hypolipoproteinemia (HP:0010981)4.23982564
14Epidermoid cyst (HP:0200040)4.21393017
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.08785227
16Hyperammonemia (HP:0001987)4.03537218
17Hyperglycinemia (HP:0002154)4.03074432
18Hypoalphalipoproteinemia (HP:0003233)3.95842704
19Abnormality of sulfur amino acid metabolism (HP:0004339)3.93217835
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.91199630
21Ketosis (HP:0001946)3.88477136
22Abnormality of the common coagulation pathway (HP:0010990)3.84181259
23Hyperglycinuria (HP:0003108)3.76306600
24Abnormality of glycine metabolism (HP:0010895)3.68644425
25Abnormality of serine family amino acid metabolism (HP:0010894)3.68644425
26Neurofibrillary tangles (HP:0002185)3.59113475
27Joint hemorrhage (HP:0005261)3.57309713
28Fat malabsorption (HP:0002630)3.55518516
29Abnormality of complement system (HP:0005339)3.54125657
30Hypercholesterolemia (HP:0003124)3.48923059
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.32920668
32Abnormality of methionine metabolism (HP:0010901)3.22127909
33Myocardial infarction (HP:0001658)3.21754167
34Premature rupture of membranes (HP:0001788)3.20972491
35Cerebral inclusion bodies (HP:0100314)3.19054099
36Hypoglycemic coma (HP:0001325)3.17037549
37Conjugated hyperbilirubinemia (HP:0002908)3.14373557
38Protrusio acetabuli (HP:0003179)3.12819714
39Hepatocellular carcinoma (HP:0001402)3.11717169
40Abnormality of the intrinsic pathway (HP:0010989)3.06676921
41Dysostosis multiplex (HP:0000943)3.06570877
42Abnormality of pyrimidine metabolism (HP:0004353)2.99686264
43Skin nodule (HP:0200036)2.83773940
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.82543530
45Gout (HP:0001997)2.75799409
46Increased connective tissue (HP:0009025)2.75330526
47Spastic diplegia (HP:0001264)2.75127158
48Abnormality of nucleobase metabolism (HP:0010932)2.73776438
49Hyperbilirubinemia (HP:0002904)2.73081173
50Increased variability in muscle fiber diameter (HP:0003557)2.72849230
51Loss of speech (HP:0002371)2.72502856
52Ketoacidosis (HP:0001993)2.71959321
53Abnormality of fatty-acid metabolism (HP:0004359)2.69440085
54Supranuclear gaze palsy (HP:0000605)2.68989573
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.67147201
56Abnormality of polysaccharide metabolism (HP:0011012)2.67147201
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.67147201
58Centrally nucleated skeletal muscle fibers (HP:0003687)2.67135950
59Abnormality of macrophages (HP:0004311)2.62804030
60Mitral stenosis (HP:0001718)2.61042698
61Abnormality of purine metabolism (HP:0004352)2.60821525
62Hypochromic microcytic anemia (HP:0004840)2.60346750
63Abnormality of the lower motor neuron (HP:0002366)2.60002597
64Vertebral compression fractures (HP:0002953)2.59501487
65Abnormality of skeletal muscle fiber size (HP:0012084)2.54734873
66Eczematoid dermatitis (HP:0000976)2.51641037
67Exercise-induced myalgia (HP:0003738)2.51517163
68Hand muscle atrophy (HP:0009130)2.47652215
69Distal upper limb amyotrophy (HP:0007149)2.47391287
70Upper limb amyotrophy (HP:0009129)2.47391287
71Vascular calcification (HP:0004934)2.44949476
72Steatorrhea (HP:0002570)2.43703947
73Mucopolysacchariduria (HP:0008155)2.42366875
74Urinary glycosaminoglycan excretion (HP:0003541)2.42366875
75Spontaneous abortion (HP:0005268)2.40470280
76Abnormality of serum amino acid levels (HP:0003112)2.39932091
77Neuronal loss in central nervous system (HP:0002529)2.38765531
78Delayed CNS myelination (HP:0002188)2.37297281
79Hypercortisolism (HP:0001578)2.36292338
80Cerebral aneurysm (HP:0004944)2.35632685
81Systemic lupus erythematosus (HP:0002725)2.35378250
82Distal lower limb amyotrophy (HP:0008944)2.33869436
83Cholelithiasis (HP:0001081)2.33355653
84Cardiovascular calcification (HP:0011915)2.32439813
85Increased cerebral lipofuscin (HP:0011813)2.31966991
86Vacuolated lymphocytes (HP:0001922)2.31568950
87Hemorrhage of the eye (HP:0011885)2.30896332
88Turricephaly (HP:0000262)2.30473276
89Apathy (HP:0000741)2.30150119
90Hydroxyprolinuria (HP:0003080)2.29996135
91Abnormality of proline metabolism (HP:0010907)2.29996135
92Esophageal varix (HP:0002040)2.28680812
93Acanthocytosis (HP:0001927)2.27771161
94Malnutrition (HP:0004395)2.27156562
95Abnormal gallbladder morphology (HP:0012437)2.26467849
96Hypoplasia of the iris (HP:0007676)2.26210710
97Spinal rigidity (HP:0003306)2.25911639
98Neonatal onset (HP:0003623)2.23684118
99Abnormality of the Achilles tendon (HP:0005109)2.21686410
100Asymmetric septal hypertrophy (HP:0001670)2.20960237
101Interstitial pulmonary disease (HP:0006530)2.19604925
102Diminished motivation (HP:0000745)2.18938014
103Distal lower limb muscle weakness (HP:0009053)2.18650210
104Abnormal gallbladder physiology (HP:0012438)2.18591087
105Cholecystitis (HP:0001082)2.18591087
106Type 1 muscle fiber predominance (HP:0003803)2.18381199
107Sensorimotor neuropathy (HP:0007141)2.16095012
108Slender build (HP:0001533)2.15521383
109Abnormal cartilage morphology (HP:0002763)2.12854672
110Vascular tortuosity (HP:0004948)2.09632996
111Atrophic scars (HP:0001075)2.07961742
112Irritability (HP:0000737)2.07392925
113Global brain atrophy (HP:0002283)2.05723888
114Aneurysm (HP:0002617)2.04957109
115Cervical subluxation (HP:0003308)2.04210375
116Difficulty climbing stairs (HP:0003551)2.04034951
117Pseudobulbar signs (HP:0002200)2.03030797
118Genu recurvatum (HP:0002816)2.02763804
119Hypoglycemic seizures (HP:0002173)2.02659005
120Back pain (HP:0003418)2.02412231
121Metabolic acidosis (HP:0001942)2.01594412
122Reticulocytosis (HP:0001923)2.00790581
123Upper motor neuron abnormality (HP:0002127)1.99947553
124Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.99252848
125Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98772752
126Prolonged neonatal jaundice (HP:0006579)1.98403647
127Hyperglycemia (HP:0003074)1.96474098
128Myositis (HP:0100614)1.94739166
129Short nail (HP:0001799)1.94229594
130Recurrent abscess formation (HP:0002722)1.93253162
131Recurrent bacterial skin infections (HP:0005406)1.91956985
132Wormian bones (HP:0002645)1.91753832
133Status epilepticus (HP:0002133)1.91511327
134Orchitis (HP:0100796)1.90935525
135Abnormal enzyme/coenzyme activity (HP:0012379)1.89609609
136Ankle contracture (HP:0006466)1.88857635
137Stroke (HP:0001297)1.88779344
138Arterial tortuosity (HP:0005116)1.88168401
139Hyperinsulinemic hypoglycemia (HP:0000825)1.86989404
140Mutism (HP:0002300)1.86241538
141Dilatation of the ascending aorta (HP:0005111)1.85053103
142Late onset (HP:0003584)1.83905658
143Amyloidosis (HP:0011034)1.83299127
144Peripheral hypomyelination (HP:0007182)1.83157080
145Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82568536
146Dicarboxylic aciduria (HP:0003215)1.82568536
147Poikilocytosis (HP:0004447)1.82553517
148Wrist flexion contracture (HP:0001239)1.80550813
149Glomerulonephritis (HP:0000099)1.79489797
150Abnormality of transition element cation homeostasis (HP:0011030)1.78514127
151Spastic tetraparesis (HP:0001285)1.78490986
152Abnormality of the gallbladder (HP:0005264)1.78070982
153Albinism (HP:0001022)1.77977058
154Increased purine levels (HP:0004368)1.77535974
155Hyperuricemia (HP:0002149)1.77535974
156Tetraparesis (HP:0002273)1.76614317
157Myopathic facies (HP:0002058)1.76379353
158Polycythemia (HP:0001901)1.76052253
159Death in childhood (HP:0003819)1.75161372
160Aortic aneurysm (HP:0004942)1.75154546
161Hyporeflexia of lower limbs (HP:0002600)1.74159975
162Rapidly progressive (HP:0003678)1.74072981
163Lower limb amyotrophy (HP:0007210)1.73990992
164Nuclear cataract (HP:0100018)1.73138937
165Peritonitis (HP:0002586)1.72980539
166Gingival bleeding (HP:0000225)1.72936547
167Long palpebral fissure (HP:0000637)1.72410468
168Spontaneous hematomas (HP:0007420)1.72265279
169Spondylolisthesis (HP:0003302)1.71868650
170Overgrowth (HP:0001548)1.71300846
171J-shaped sella turcica (HP:0002680)1.70778074
172Tetraplegia (HP:0002445)1.69150077
173Decreased motor nerve conduction velocity (HP:0003431)1.68755658
174Abnormality of alkaline phosphatase activity (HP:0004379)1.67535195
175Abnormality of iron homeostasis (HP:0011031)1.67523751
176Obstructive sleep apnea (HP:0002870)1.66610283
177Muscle fiber splitting (HP:0003555)1.65515370
178Disinhibition (HP:0000734)1.63795489
179Muscle fibrillation (HP:0010546)1.63695458
180Nephritis (HP:0000123)1.63338709
181Difficulty running (HP:0009046)1.61908606
182Deformed sella turcica (HP:0002681)1.61672655
183Recurrent gram-negative bacterial infections (HP:0005420)1.60864159
184Thin bony cortex (HP:0002753)1.60191768
185Increased neuronal autofluorescent lipopigment (HP:0002074)1.60090911
186Gingivitis (HP:0000230)1.58155201
187Achilles tendon contracture (HP:0001771)1.57777781
188Aortic dissection (HP:0002647)1.57381844
189Ankle clonus (HP:0011448)1.56389552
190Mildly elevated creatine phosphokinase (HP:0008180)1.56107778
191Bilateral sensorineural hearing impairment (HP:0008619)1.55928861
192Neoplasm of the heart (HP:0100544)1.54587659

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.89578867
2SIK13.84690129
3ERN13.34905471
4BCKDK3.15242607
5FGFR43.07944756
6PKN22.82013610
7PRPF4B2.63710427
8ICK2.36277400
9MAP2K32.15939353
10FLT32.02651467
11MAP3K102.00666766
12LATS11.95885836
13MAP3K61.92116621
14PTK61.91898196
15PDGFRA1.77579839
16TESK11.76993453
17CDK121.72102866
18MAP3K31.70898493
19MARK21.69603881
20RIPK11.66542592
21PDK41.60002397
22PDK31.60002397
23ERBB41.53211718
24EPHB21.49963388
25EPHB11.48371935
26IRAK31.46719135
27TYRO31.45286043
28CAMK1D1.44034241
29PRKD21.40021984
30MAP3K111.39254277
31MET1.35261655
32TESK21.31909853
33KSR21.29617845
34EEF2K1.29038473
35TAOK31.28816717
36SIK31.26869712
37ZAP701.25714208
38MTOR1.25084415
39DAPK21.24120158
40SGK31.22530632
41CSK1.22466302
42MAP2K71.21342820
43MAPK111.18683268
44BLK1.18479451
45MAP3K71.16144364
46FGFR21.15460280
47TGFBR21.14871015
48DYRK1B1.13537409
49TTN1.12051701
50FGR1.10859808
51PTK21.10673791
52INSRR1.10361527
53MAP2K41.10094672
54CDC42BPA1.07682376
55CAMK1G1.06900830
56MAP3K141.06801088
57MST1R1.06712128
58MAP3K41.06712026
59RET1.06425710
60MARK11.06101969
61LATS21.06012583
62NTRK11.05049806
63STK381.00960423
64PRKD31.00954985
65NEK11.00419796
66BMX0.99467535
67MAP3K90.99380120
68PDK20.97252589
69TYK20.96258465
70MAP4K10.96175446
71EPHA20.93989538
72JAK20.90778975
73RPS6KA20.89686434
74MAP3K50.89483491
75PDPK10.89291694
76CDK60.89231214
77PINK10.89212982
78PRKAA10.88836168
79JAK10.88783154
80NEK90.87282484
81DDR20.87037682
82MATK0.85394348
83IRAK20.81914773
84MAP3K10.81859024
85MOS0.80010762
86ERBB20.79835385
87GRK70.78681067
88LIMK10.78107054
89STK30.78057383
90PDK10.77573264
91PAK60.76232342
92JAK30.74985427
93IRAK40.74797093
94PRKAA20.74615734
95CAMKK10.71081032
96CSF1R0.69483797
97FES0.69156129
98PRKCZ0.68458643
99MAPK70.67410536
100PIM20.67165324
101TRIM280.66350105
102TAOK10.63918195
103HCK0.63869841
104GRK60.63006481
105KSR10.61784533
106FGFR30.61430634
107PDGFRB0.60968600
108IKBKE0.60311970
109MARK30.59592323
110EPHA30.58851213
111RIPK40.58647001
112PAK30.58107355
113PIK3CG0.56680083
114PRKD10.56520729
115PHKG20.55255221
116PHKG10.55255221
117MAP3K20.54842417
118LMTK20.54338910
119DYRK30.53373280
120PRKCH0.52439498
121SGK4940.51717755
122SGK2230.51717755
123PAK40.51443338
124GSK3A0.50609795
125TAOK20.50489494
126SGK20.50345012
127LRRK20.49816708
128TNK20.49633865
129AKT30.49073759
130RPS6KC10.48690630
131RPS6KL10.48690630
132MAPK40.48313861
133ALK0.47598350
134FYN0.46483119
135PRKACG0.43308520
136PAK20.42468212
137MAP2K10.41983720
138MAP3K80.41858040
139ABL20.41517980
140SIK20.40850754
141TBK10.40362064
142MAPK120.39574991
143NEK20.38991049
144SCYL20.38229268
145MELK0.35379976
146PTK2B0.35149841
147CAMK40.34950352
148FGFR10.34036109
149FRK0.32437180
150STK38L0.31918769

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.22911568
2Nitrogen metabolism_Homo sapiens_hsa009104.12415603
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.49917141
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.08732190
5Arginine biosynthesis_Homo sapiens_hsa002203.07903050
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55888372
7Tryptophan metabolism_Homo sapiens_hsa003802.54500114
8Fatty acid degradation_Homo sapiens_hsa000712.52624026
9Complement and coagulation cascades_Homo sapiens_hsa046102.49534029
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.49208450
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31816603
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23543012
13PPAR signaling pathway_Homo sapiens_hsa033202.06689704
14Butanoate metabolism_Homo sapiens_hsa006502.02531319
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95273246
16Fatty acid metabolism_Homo sapiens_hsa012121.93088509
17Propanoate metabolism_Homo sapiens_hsa006401.86704125
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.84686913
19Peroxisome_Homo sapiens_hsa041461.79145210
20Osteoclast differentiation_Homo sapiens_hsa043801.77486079
21Other glycan degradation_Homo sapiens_hsa005111.77091180
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74507502
23Bile secretion_Homo sapiens_hsa049761.74284608
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.72275811
25Caffeine metabolism_Homo sapiens_hsa002321.64207108
26Chemical carcinogenesis_Homo sapiens_hsa052041.59451158
27Selenocompound metabolism_Homo sapiens_hsa004501.58962359
28Histidine metabolism_Homo sapiens_hsa003401.57507495
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56938174
30Acute myeloid leukemia_Homo sapiens_hsa052211.52784910
31Staphylococcus aureus infection_Homo sapiens_hsa051501.52343960
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51258204
33beta-Alanine metabolism_Homo sapiens_hsa004101.49630661
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47760123
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47375524
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.46941347
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44865176
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.44422267
39Notch signaling pathway_Homo sapiens_hsa043301.41826586
40Renal cell carcinoma_Homo sapiens_hsa052111.40204759
41Malaria_Homo sapiens_hsa051441.39270586
42Vitamin B6 metabolism_Homo sapiens_hsa007501.37823053
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31189757
44Retinol metabolism_Homo sapiens_hsa008301.30722163
45Phenylalanine metabolism_Homo sapiens_hsa003601.30352602
46Pyruvate metabolism_Homo sapiens_hsa006201.28381914
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.27674495
48Biosynthesis of amino acids_Homo sapiens_hsa012301.27515055
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27211838
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26852166
51Salmonella infection_Homo sapiens_hsa051321.26183435
52Fat digestion and absorption_Homo sapiens_hsa049751.25674666
53ABC transporters_Homo sapiens_hsa020101.23124911
54VEGF signaling pathway_Homo sapiens_hsa043701.22900855
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.22549427
56Starch and sucrose metabolism_Homo sapiens_hsa005001.22374084
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20532781
58Vibrio cholerae infection_Homo sapiens_hsa051101.20483201
59Shigellosis_Homo sapiens_hsa051311.19260434
60Phospholipase D signaling pathway_Homo sapiens_hsa040721.18867842
61Tuberculosis_Homo sapiens_hsa051521.18428381
62Chronic myeloid leukemia_Homo sapiens_hsa052201.18277887
63Lysine degradation_Homo sapiens_hsa003101.18197548
64Phagosome_Homo sapiens_hsa041451.16714090
65Tyrosine metabolism_Homo sapiens_hsa003501.16419197
66Carbon metabolism_Homo sapiens_hsa012001.16326750
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14240842
68Hepatitis C_Homo sapiens_hsa051601.12673401
69TNF signaling pathway_Homo sapiens_hsa046681.11590795
70Cysteine and methionine metabolism_Homo sapiens_hsa002701.11373331
71Sphingolipid signaling pathway_Homo sapiens_hsa040711.10218390
72Endocytosis_Homo sapiens_hsa041441.09959648
73Pancreatic cancer_Homo sapiens_hsa052121.08490285
74Prolactin signaling pathway_Homo sapiens_hsa049171.08404633
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08362573
76Fatty acid biosynthesis_Homo sapiens_hsa000611.06305038
77Leukocyte transendothelial migration_Homo sapiens_hsa046701.05720146
78Synaptic vesicle cycle_Homo sapiens_hsa047211.05069677
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04238920
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03194416
81Regulation of autophagy_Homo sapiens_hsa041401.02589222
82Focal adhesion_Homo sapiens_hsa045101.01063433
83Pertussis_Homo sapiens_hsa051331.01001203
84GnRH signaling pathway_Homo sapiens_hsa049121.00752206
85Toxoplasmosis_Homo sapiens_hsa051451.00750438
86Endometrial cancer_Homo sapiens_hsa052130.99681453
87Leishmaniasis_Homo sapiens_hsa051400.95613455
88Chemokine signaling pathway_Homo sapiens_hsa040620.94732006
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93993087
90Sulfur metabolism_Homo sapiens_hsa009200.93930786
91ErbB signaling pathway_Homo sapiens_hsa040120.91949539
92Choline metabolism in cancer_Homo sapiens_hsa052310.91506761
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90484155
94Glycerolipid metabolism_Homo sapiens_hsa005610.90396679
95Folate biosynthesis_Homo sapiens_hsa007900.89124254
96Arginine and proline metabolism_Homo sapiens_hsa003300.88206223
97B cell receptor signaling pathway_Homo sapiens_hsa046620.87896843
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87865798
99Glioma_Homo sapiens_hsa052140.85658715
100Hepatitis B_Homo sapiens_hsa051610.84291578
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83832443
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83474774
103Steroid biosynthesis_Homo sapiens_hsa001000.82088313
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80260033
105Influenza A_Homo sapiens_hsa051640.79919575
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.79005761
107Apoptosis_Homo sapiens_hsa042100.78995703
108Fatty acid elongation_Homo sapiens_hsa000620.78708350
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77393219
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77019106
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77013019
112Vitamin digestion and absorption_Homo sapiens_hsa049770.76912800
113Sulfur relay system_Homo sapiens_hsa041220.76017069
114Inositol phosphate metabolism_Homo sapiens_hsa005620.75893608
115Collecting duct acid secretion_Homo sapiens_hsa049660.74882110
116Proteoglycans in cancer_Homo sapiens_hsa052050.72812444
117Sphingolipid metabolism_Homo sapiens_hsa006000.72398972
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.71334556
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69089078
120HIF-1 signaling pathway_Homo sapiens_hsa040660.67770523
121Platelet activation_Homo sapiens_hsa046110.67003814
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.66881556
123Axon guidance_Homo sapiens_hsa043600.66440530
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65931695
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65539021
126Rap1 signaling pathway_Homo sapiens_hsa040150.65308815
127Pentose phosphate pathway_Homo sapiens_hsa000300.65167793
128Rheumatoid arthritis_Homo sapiens_hsa053230.64736708
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64666381
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.64253656
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63889778
132African trypanosomiasis_Homo sapiens_hsa051430.62192225
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62008091
134Insulin resistance_Homo sapiens_hsa049310.61560551
135MAPK signaling pathway_Homo sapiens_hsa040100.60927552
136Legionellosis_Homo sapiens_hsa051340.60160648
137Dilated cardiomyopathy_Homo sapiens_hsa054140.58796518
138Estrogen signaling pathway_Homo sapiens_hsa049150.58163504
139Gap junction_Homo sapiens_hsa045400.55817537
140Small cell lung cancer_Homo sapiens_hsa052220.55453018
141Prion diseases_Homo sapiens_hsa050200.55341669
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.54563113
143Measles_Homo sapiens_hsa051620.53269140
144T cell receptor signaling pathway_Homo sapiens_hsa046600.52985524
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51891997
146Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50239792
147Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49985037
148One carbon pool by folate_Homo sapiens_hsa006700.47701567
149Fructose and mannose metabolism_Homo sapiens_hsa000510.46760968
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45129710
151Glutathione metabolism_Homo sapiens_hsa004800.43940601
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.41476659
153AMPK signaling pathway_Homo sapiens_hsa041520.39369272
154Glucagon signaling pathway_Homo sapiens_hsa049220.36297891
155Galactose metabolism_Homo sapiens_hsa000520.34718321
156Central carbon metabolism in cancer_Homo sapiens_hsa052300.26250703
157Insulin signaling pathway_Homo sapiens_hsa049100.23281434
158alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21617920
159mTOR signaling pathway_Homo sapiens_hsa041500.21013747
160Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20899025
161Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19721580
162Metabolic pathways_Homo sapiens_hsa011000.19098046
163Type II diabetes mellitus_Homo sapiens_hsa049300.17972331
164Glycosaminoglycan degradation_Homo sapiens_hsa005310.16095981
165Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14801388
166Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.13389042
167Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.08219235
168Amoebiasis_Homo sapiens_hsa051460.07594857
169Bladder cancer_Homo sapiens_hsa052190.06641979
170Dorso-ventral axis formation_Homo sapiens_hsa043200.05295438
171Linoleic acid metabolism_Homo sapiens_hsa005910.02771035
172Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.00121246
173FoxO signaling pathway_Homo sapiens_hsa04068-0.0669018
174Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0394707
175Protein digestion and absorption_Homo sapiens_hsa04974-0.0289572
176Renin-angiotensin system_Homo sapiens_hsa04614-0.0279606
177Non-small cell lung cancer_Homo sapiens_hsa05223-0.0249768
178Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0208409
179Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0132764
180Lysosome_Homo sapiens_hsa04142-0.0033113

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