ZFYVE16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.85255947
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.60782400
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.38959446
4cellular response to ethanol (GO:0071361)3.38017554
5neural tube formation (GO:0001841)3.24383102
6oligosaccharide catabolic process (GO:0009313)3.10317356
7chondrocyte development (GO:0002063)3.04940257
8response to pheromone (GO:0019236)2.97672232
9presynaptic membrane organization (GO:0097090)2.93656147
10axon ensheathment in central nervous system (GO:0032291)2.93345586
11central nervous system myelination (GO:0022010)2.93345586
12regulation of non-canonical Wnt signaling pathway (GO:2000050)2.91285470
13limb bud formation (GO:0060174)2.90760135
14interkinetic nuclear migration (GO:0022027)2.90263456
15nerve growth factor signaling pathway (GO:0038180)2.89247918
16neutrophil activation involved in immune response (GO:0002283)2.87412729
17collagen fibril organization (GO:0030199)2.81669042
18nucleus localization (GO:0051647)2.80950334
19asymmetric protein localization (GO:0008105)2.74274357
20negative regulation of systemic arterial blood pressure (GO:0003085)2.72003229
21cytoplasmic mRNA processing body assembly (GO:0033962)2.71952922
22platelet-derived growth factor receptor signaling pathway (GO:0048008)2.70974981
23response to lipoprotein particle (GO:0055094)2.70330319
24proline transport (GO:0015824)2.67878329
25prostate gland growth (GO:0060736)2.67282182
26intraciliary transport (GO:0042073)2.66129414
27negative regulation of neurotransmitter secretion (GO:0046929)2.65891344
28relaxation of cardiac muscle (GO:0055119)2.65261498
29pericardium development (GO:0060039)2.63171991
30negative regulation of axon guidance (GO:1902668)2.61904991
31negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.60853679
32membrane raft organization (GO:0031579)2.60832630
33platelet dense granule organization (GO:0060155)2.60395606
34negative regulation of mast cell activation (GO:0033004)2.59139461
35cell adhesion mediated by integrin (GO:0033627)2.54639681
36mesenchymal-epithelial cell signaling (GO:0060638)2.53742946
37iron ion import (GO:0097286)2.53686706
38prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.53460248
39regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.53166289
40branching involved in prostate gland morphogenesis (GO:0060442)2.52483166
41retina vasculature morphogenesis in camera-type eye (GO:0061299)2.52215034
42regulation of interferon-beta biosynthetic process (GO:0045357)2.50326215
43I-kappaB phosphorylation (GO:0007252)2.50118759
44pyrimidine nucleobase catabolic process (GO:0006208)2.49743041
45cilium organization (GO:0044782)2.49149454
46ER overload response (GO:0006983)2.47817033
47protein K11-linked deubiquitination (GO:0035871)2.47281319
48retinal ganglion cell axon guidance (GO:0031290)2.46857520
49insulin-like growth factor receptor signaling pathway (GO:0048009)2.46256109
50negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.45612561
51negative regulation of translation, ncRNA-mediated (GO:0040033)2.45612561
52regulation of translation, ncRNA-mediated (GO:0045974)2.45612561
53cilium assembly (GO:0042384)2.44793236
54phospholipid translocation (GO:0045332)2.44128881
55lipid translocation (GO:0034204)2.44128881
56cilium morphogenesis (GO:0060271)2.44058520
57establishment of nucleus localization (GO:0040023)2.43661299
58regulation of heat generation (GO:0031650)2.42636518
59protein localization to cilium (GO:0061512)2.42612192
60glycosphingolipid catabolic process (GO:0046479)2.42196231
61photoreceptor cell differentiation (GO:0046530)2.41451779
62eye photoreceptor cell differentiation (GO:0001754)2.41451779
63positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.41382634
64retina layer formation (GO:0010842)2.40894128
65cilium or flagellum-dependent cell motility (GO:0001539)2.40717387
66inner ear receptor stereocilium organization (GO:0060122)2.40211140
67ganglioside metabolic process (GO:0001573)2.39938281
68embryonic foregut morphogenesis (GO:0048617)2.38148348
69regulation of sarcomere organization (GO:0060297)2.38058588
70wound healing, spreading of epidermal cells (GO:0035313)2.37528082
71regulation of mononuclear cell migration (GO:0071675)2.37032188
72membrane assembly (GO:0071709)2.36619572
73negative regulation of Rho protein signal transduction (GO:0035024)2.35678814
74establishment of protein localization to Golgi (GO:0072600)2.35225556
75neuronal stem cell maintenance (GO:0097150)2.34522813
76macroautophagy (GO:0016236)2.33159754
77modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.32864029
78positive regulation by organism of defense response of other organism involved in symbiotic interact2.32864029
79modulation by symbiont of host immune response (GO:0052553)2.32864029
80positive regulation by symbiont of host defense response (GO:0052509)2.32864029
81modulation by symbiont of host defense response (GO:0052031)2.32864029
82modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.32864029
83negative regulation of cytosolic calcium ion concentration (GO:0051481)2.32791280
84interleukin-6-mediated signaling pathway (GO:0070102)2.32650183
85nonmotile primary cilium assembly (GO:0035058)2.31592380
86dendrite morphogenesis (GO:0048813)2.31168210
87axonal fasciculation (GO:0007413)2.30687570
88detection of molecule of bacterial origin (GO:0032490)2.30259731
89regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.28256006
90negative chemotaxis (GO:0050919)2.27818330
91regulation of chemokine-mediated signaling pathway (GO:0070099)2.27792436
92nucleobase catabolic process (GO:0046113)2.26822711
93lymph vessel development (GO:0001945)2.26433901
94regulation of axon guidance (GO:1902667)2.25419517
95detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.25344960
96chondrocyte proliferation (GO:0035988)2.25241098
97endosome to pigment granule transport (GO:0043485)2.25221680
98endosome to melanosome transport (GO:0035646)2.25221680
99regulation of oligodendrocyte differentiation (GO:0048713)2.24371728
100central nervous system neuron axonogenesis (GO:0021955)2.24263872
101negative regulation of oligodendrocyte differentiation (GO:0048715)2.23664159
102regulation of fibroblast apoptotic process (GO:2000269)2.23524722
103otic vesicle formation (GO:0030916)2.23173200
104myelin assembly (GO:0032288)2.23155030
105regulation of protein polyubiquitination (GO:1902914)2.22472564
106urinary tract smooth muscle contraction (GO:0014848)2.22428868
107protein localization to endosome (GO:0036010)2.22098717
108pigment cell differentiation (GO:0050931)2.21967288
109glutamate receptor signaling pathway (GO:0007215)2.21829360
110cilium movement (GO:0003341)2.21467621
111cyclic nucleotide catabolic process (GO:0009214)2.19678044
112appendage development (GO:0048736)2.19256331
113limb development (GO:0060173)2.19256331
114smoothened signaling pathway (GO:0007224)2.19198007
115retinal rod cell development (GO:0046548)2.19179368
116cellular response to cholesterol (GO:0071397)2.17941865
117cAMP catabolic process (GO:0006198)2.17756917
118negative regulation of fibroblast apoptotic process (GO:2000270)2.17446294
119lung lobe morphogenesis (GO:0060463)2.17221437
120import into cell (GO:0098657)2.17072600
121regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.16961541
122positive regulation of smooth muscle cell migration (GO:0014911)2.16733382
123positive regulation of developmental pigmentation (GO:0048087)2.15672098
124extracellular matrix assembly (GO:0085029)2.15620156
125negative regulation of sodium ion transport (GO:0010766)2.15249089
126regulation of energy homeostasis (GO:2000505)2.14335371
127negative regulation of neurotransmitter transport (GO:0051589)2.12291891
128positive regulation of osteoblast proliferation (GO:0033690)2.12039147
129epithelial cilium movement (GO:0003351)2.11564847
130glycolipid catabolic process (GO:0019377)2.11553969
131osteoclast differentiation (GO:0030316)2.11063384
132positive regulation of muscle hypertrophy (GO:0014742)2.10875383
133positive regulation of cardiac muscle hypertrophy (GO:0010613)2.10875383
134cellular component assembly involved in morphogenesis (GO:0010927)2.10869517
135regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.10164470
136myelin maintenance (GO:0043217)2.09802842
137glycoprotein catabolic process (GO:0006516)2.09708753
138response to cholesterol (GO:0070723)2.09423825
139negative regulation of hormone biosynthetic process (GO:0032353)2.09016600
140retinal cone cell development (GO:0046549)2.08751851
141pancreas development (GO:0031016)2.08625044
142negative regulation of anoikis (GO:2000811)2.06930861
143growth hormone receptor signaling pathway (GO:0060396)2.06475792
144regulation of osteoblast proliferation (GO:0033688)2.04726377
145glomerular visceral epithelial cell development (GO:0072015)2.03961850
146regulation of pigment cell differentiation (GO:0050932)2.03393812
147axon extension involved in axon guidance (GO:0048846)2.03368649
148neuron projection extension involved in neuron projection guidance (GO:1902284)2.03368649
149Golgi to endosome transport (GO:0006895)2.03111291
150regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.02899626
151apical protein localization (GO:0045176)2.01100194
152vesicle fusion (GO:0006906)2.00828943
153myelination (GO:0042552)1.99997097
154cellular response to vitamin D (GO:0071305)1.98792651
155ensheathment of neurons (GO:0007272)1.98470359
156axon ensheathment (GO:0008366)1.98470359
157apoptotic cell clearance (GO:0043277)1.97994463
158mesodermal cell differentiation (GO:0048333)1.97827371
159adhesion of symbiont to host cell (GO:0044650)1.96945153
160virion attachment to host cell (GO:0019062)1.96945153
161positive regulation of actin filament depolymerization (GO:0030836)1.96887273
162artery development (GO:0060840)1.96637064
163protein localization to cell surface (GO:0034394)1.95560088
164cellular response to vitamin (GO:0071295)1.95081194
165negative regulation of osteoclast differentiation (GO:0045671)1.93604299
166sequestering of extracellular ligand from receptor (GO:0035581)1.93431800
167peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)1.92090475
168positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)1.90453857
169cellular response to interferon-alpha (GO:0035457)1.89639110
170endothelial cell morphogenesis (GO:0001886)1.89489955
171wound healing, spreading of cells (GO:0044319)1.89172424
172hippo signaling (GO:0035329)1.88947758
173regulation of nitric-oxide synthase biosynthetic process (GO:0051769)1.88554401
174regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450911.87508736
175positive regulation of oligodendrocyte differentiation (GO:0048714)1.86892341
176cartilage development involved in endochondral bone morphogenesis (GO:0060351)1.85585442
177positive regulation of bone mineralization (GO:0030501)1.85484050
178vascular smooth muscle contraction (GO:0014829)1.85399289
179substrate-dependent cell migration (GO:0006929)1.84820331
180lateral sprouting from an epithelium (GO:0060601)1.83569574
181microglial cell activation (GO:0001774)1.83216476
182presynaptic membrane assembly (GO:0097105)1.83202602
183regulation of smooth muscle cell migration (GO:0014910)1.82802096
184lung alveolus development (GO:0048286)1.82504024
185cellular response to growth hormone stimulus (GO:0071378)1.81997671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.03177063
2SMAD_19615063_ChIP-ChIP_OVARY_Human2.52102083
3GBX2_23144817_ChIP-Seq_PC3_Human2.40587600
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37395628
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.37300922
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.27091296
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.10636800
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09008988
9NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.08373089
10NRF2_20460467_ChIP-Seq_MEFs_Mouse2.08373089
11TAF15_26573619_Chip-Seq_HEK293_Human2.07694900
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03043521
13ZNF217_24962896_ChIP-Seq_MCF-7_Human1.94701371
14PIAS1_25552417_ChIP-Seq_VCAP_Human1.93448074
15WT1_19549856_ChIP-ChIP_CCG9911_Human1.92656072
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.89512329
17SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88630863
18OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87524637
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84274794
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80181736
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78407865
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74987984
23CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.72917322
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71639340
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.70426377
26AR_21572438_ChIP-Seq_LNCaP_Human1.69126067
27P300_19829295_ChIP-Seq_ESCs_Human1.67258556
28* CJUN_26792858_Chip-Seq_BT549_Human1.65732295
29ZNF274_21170338_ChIP-Seq_K562_Hela1.65151759
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62585641
31TP53_18474530_ChIP-ChIP_U2OS_Human1.60503329
32VDR_22108803_ChIP-Seq_LS180_Human1.60412813
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.59650416
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59189252
35TP53_16413492_ChIP-PET_HCT116_Human1.59113248
36SMAD4_21799915_ChIP-Seq_A2780_Human1.57270375
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56225922
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56225922
39EZH2_22144423_ChIP-Seq_EOC_Human1.54847317
40FUS_26573619_Chip-Seq_HEK293_Human1.53011551
41IGF1R_20145208_ChIP-Seq_DFB_Human1.51529193
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48525915
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.44892014
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44740635
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.42815765
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.41979554
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39631351
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.38503021
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37829042
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.37323847
51ER_23166858_ChIP-Seq_MCF-7_Human1.36872049
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36460925
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34639994
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33442035
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33063695
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31979896
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31203429
58STAT3_23295773_ChIP-Seq_U87_Human1.31060801
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30630767
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.30258417
61SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30062018
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28548005
63CBP_20019798_ChIP-Seq_JUKART_Human1.28548005
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28164559
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.27626622
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27578042
67BCAT_22108803_ChIP-Seq_LS180_Human1.27241809
68AHR_22903824_ChIP-Seq_MCF-7_Human1.26198927
69GATA1_22025678_ChIP-Seq_K562_Human1.25567579
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23961829
71LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22843840
72KDM2B_26808549_Chip-Seq_REH_Human1.22118797
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22063664
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.21434559
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21024048
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19991062
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19831285
78BP1_19119308_ChIP-ChIP_Hs578T_Human1.19632053
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18252686
80TCF4_23295773_ChIP-Seq_U87_Human1.18027093
81VDR_24787735_ChIP-Seq_THP-1_Human1.17576379
82TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16527381
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.14850037
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14562029
85AR_25329375_ChIP-Seq_VCAP_Human1.14407948
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13435810
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13266164
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.12582065
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.12578211
90CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12417475
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12142726
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12129463
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.11785303
94RXR_22108803_ChIP-Seq_LS180_Human1.11682547
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11078832
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.11070711
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.10235547
98NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09936456
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.09841781
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09836370
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.09653909
102FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09383654
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09035966
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08663758
105TP63_23658742_ChIP-Seq_EP156T_Human1.08615603
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07906805
107BRD4_25478319_ChIP-Seq_HGPS_Human1.07632097
108EWS_26573619_Chip-Seq_HEK293_Human1.07297890
109SMAD3_21741376_ChIP-Seq_HESCs_Human1.07017116
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06929071
111IRF8_22096565_ChIP-ChIP_GC-B_Human1.06844410
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06551623
113SMAD4_21741376_ChIP-Seq_HESCs_Human1.06542524
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06472218
115PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06224698
116IRF8_21731497_ChIP-ChIP_J774_Mouse1.05904563
117P300_18555785_Chip-Seq_ESCs_Mouse1.05872266
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05335119
119RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05163774
120EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05163774
121MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04287981
122JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03652622
123PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03397468
124SOX2_21211035_ChIP-Seq_LN229_Gbm1.03049079
125E2F1_18555785_Chip-Seq_ESCs_Mouse1.03033266
126SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02590634
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02543559
128RUNX2_22187159_ChIP-Seq_PCA_Human1.02455835
129TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01939484
130* TCF4_22108803_ChIP-Seq_LS180_Human1.01913287
131SOX2_20726797_ChIP-Seq_SW620_Human1.00967515
132CMYC_18555785_Chip-Seq_ESCs_Mouse1.00054095
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97208004
134WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97156193
135CBX2_27304074_Chip-Seq_ESCs_Mouse0.96870696
136P53_22387025_ChIP-Seq_ESCs_Mouse0.96107703

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.48213857
2MP0003136_yellow_coat_color4.24478830
3MP0005503_abnormal_tendon_morphology3.70863115
4MP0003950_abnormal_plasma_membrane3.53049394
5MP0010234_abnormal_vibrissa_follicle3.30771714
6MP0009780_abnormal_chondrocyte_physiolo3.14206892
7MP0005171_absent_coat_pigmentation3.00323453
8MP0005275_abnormal_skin_tensile2.93821520
9MP0000372_irregular_coat_pigmentation2.81199630
10MP0000569_abnormal_digit_pigmentation2.73892424
11MP0001299_abnormal_eye_distance/2.47105361
12MP0003890_abnormal_embryonic-extraembry2.40510912
13MP0004272_abnormal_basement_membrane2.33694024
14MP0005174_abnormal_tail_pigmentation2.29557634
15MP0005167_abnormal_blood-brain_barrier2.22543243
16MP0000371_diluted_coat_color2.13990273
17MP0001324_abnormal_eye_pigmentation2.12664994
18MP0005058_abnormal_lysosome_morphology1.97604729
19MP0003279_aneurysm1.91582683
20MP0001984_abnormal_olfaction1.90444245
21MP0001879_abnormal_lymphatic_vessel1.89636728
22MP0003632_abnormal_nervous_system1.88690910
23MP0000920_abnormal_myelination1.88350775
24MP0002653_abnormal_ependyma_morphology1.87819122
25MP0005623_abnormal_meninges_morphology1.86493346
26MP0010678_abnormal_skin_adnexa1.86309512
27MP0004134_abnormal_chest_morphology1.84749130
28MP0003195_calcinosis1.82322326
29MP0009250_abnormal_appendicular_skeleto1.81036796
30MP0009384_cardiac_valve_regurgitation1.79912442
31MP0005408_hypopigmentation1.79214640
32MP0006054_spinal_hemorrhage1.74556531
33MP0001958_emphysema1.73020715
34MP0004742_abnormal_vestibular_system1.69082353
35MP0009046_muscle_twitch1.67627436
36MP0000013_abnormal_adipose_tissue1.67584879
37MP0004885_abnormal_endolymph1.67396058
38MP0002095_abnormal_skin_pigmentation1.67129129
39MP0000604_amyloidosis1.62971773
40MP0003880_abnormal_central_pattern1.60260600
41MP0001486_abnormal_startle_reflex1.58898244
42MP0003091_abnormal_cell_migration1.53215018
43MP0002282_abnormal_trachea_morphology1.52830854
44MP0002896_abnormal_bone_mineralization1.51698187
45MP0002009_preneoplasia1.49906348
46MP0010386_abnormal_urinary_bladder1.49178805
47MP0002295_abnormal_pulmonary_circulatio1.48880860
48MP0000015_abnormal_ear_pigmentation1.48052925
49MP0002102_abnormal_ear_morphology1.47128112
50MP0002837_dystrophic_cardiac_calcinosis1.44236277
51MP0003690_abnormal_glial_cell1.42760859
52MP0003787_abnormal_imprinting1.35101162
53MP0009697_abnormal_copulation1.34971462
54MP0004147_increased_porphyrin_level1.33321751
55MP0002735_abnormal_chemical_nociception1.30932426
56MP0005248_abnormal_Harderian_gland1.29752419
57MP0002933_joint_inflammation1.28694879
58MP0003937_abnormal_limbs/digits/tail_de1.28679357
59MP0005646_abnormal_pituitary_gland1.27310621
60MP0003566_abnormal_cell_adhesion1.26525818
61MP0002108_abnormal_muscle_morphology1.25398941
62MP0003633_abnormal_nervous_system1.23586610
63MP0002075_abnormal_coat/hair_pigmentati1.22178618
64MP0004084_abnormal_cardiac_muscle1.22055091
65MP0002115_abnormal_skeleton_extremities1.21692222
66MP0006082_CNS_inflammation1.21440650
67MP0004036_abnormal_muscle_relaxation1.20819052
68MP0003631_nervous_system_phenotype1.19658405
69MP0002638_abnormal_pupillary_reflex1.18393084
70MP0003828_pulmonary_edema1.18381032
71MP0000383_abnormal_hair_follicle1.17808073
72MP0000733_abnormal_muscle_development1.16650283
73MP0003385_abnormal_body_wall1.14512577
74MP0003634_abnormal_glial_cell1.14164274
75MP0005195_abnormal_posterior_eye1.12994469
76MP0005257_abnormal_intraocular_pressure1.10986365
77MP0003705_abnormal_hypodermis_morpholog1.08341153
78MP0003122_maternal_imprinting1.07923577
79MP0000516_abnormal_urinary_system1.06556780
80MP0005367_renal/urinary_system_phenotyp1.06556780
81MP0005508_abnormal_skeleton_morphology1.05865179
82MP0005388_respiratory_system_phenotype1.05649822
83MP0002133_abnormal_respiratory_system1.05649822
84MP0003045_fibrosis1.05569028
85MP0002064_seizures1.05108060
86MP0002090_abnormal_vision1.04177031
87MP0000955_abnormal_spinal_cord1.03637372
88MP0009764_decreased_sensitivity_to1.02031186
89MP0005409_darkened_coat_color1.00861809
90MP0002060_abnormal_skin_morphology1.00846528
91MP0003172_abnormal_lysosome_physiology1.00205404
92MP0002067_abnormal_sensory_capabilities0.99870635
93MP0001485_abnormal_pinna_reflex0.99838043
94MP0005391_vision/eye_phenotype0.99243923
95MP0002972_abnormal_cardiac_muscle0.98821087
96MP0002233_abnormal_nose_morphology0.98499446
97MP0010368_abnormal_lymphatic_system0.98422803
98MP0006072_abnormal_retinal_apoptosis0.98213946
99MP0002998_abnormal_bone_remodeling0.98129129
100MP0000428_abnormal_craniofacial_morphol0.97856899
101MP0000163_abnormal_cartilage_morphology0.97645006
102MP0003329_amyloid_beta_deposits0.97317757
103MP0001186_pigmentation_phenotype0.97231286
104MP0000566_synostosis0.97106754
105MP0002229_neurodegeneration0.95890098
106MP0005253_abnormal_eye_physiology0.95585698
107MP0002166_altered_tumor_susceptibility0.94937965
108MP0008877_abnormal_DNA_methylation0.93350026
109MP0005076_abnormal_cell_differentiation0.92302796
110MP0002109_abnormal_limb_morphology0.92195464
111MP0001177_atelectasis0.91815416
112MP0004924_abnormal_behavior0.88164972
113MP0005386_behavior/neurological_phenoty0.88164972
114MP0000767_abnormal_smooth_muscle0.86993066
115MP0000647_abnormal_sebaceous_gland0.86846752
116MP0005075_abnormal_melanosome_morpholog0.86442077
117MP0004133_heterotaxia0.86375109
118MP0003283_abnormal_digestive_organ0.86367723
119MP0005164_abnormal_response_to0.86213788
120MP0003755_abnormal_palate_morphology0.85535892
121MP0004484_altered_response_of0.85104886
122MP0005197_abnormal_uvea_morphology0.84685919
123MP0001293_anophthalmia0.84674664
124MP0002938_white_spotting0.84436931
125MP0001340_abnormal_eyelid_morphology0.83100782
126MP0002572_abnormal_emotion/affect_behav0.82810848
127MP0004142_abnormal_muscle_tone0.82546350
128MP0000003_abnormal_adipose_tissue0.81302105
129MP0008775_abnormal_heart_ventricle0.80736094
130MP0001440_abnormal_grooming_behavior0.80451415
131MP0004043_abnormal_pH_regulation0.80094691
132MP0004510_myositis0.80068264
133MP0005187_abnormal_penis_morphology0.80058475
134MP0004215_abnormal_myocardial_fiber0.80011461
135MP0010352_gastrointestinal_tract_polyps0.79211332
136MP0002113_abnormal_skeleton_development0.78953570
137MP0000465_gastrointestinal_hemorrhage0.78757936
138MP0009745_abnormal_behavioral_response0.78319905
139MP0002272_abnormal_nervous_system0.78252565
140MP0009840_abnormal_foam_cell0.77595270
141MP0000778_abnormal_nervous_system0.77022647
142MP0004270_analgesia0.76269234
143MP0004883_abnormal_blood_vessel0.76149494
144MP0002752_abnormal_somatic_nervous0.75891145
145MP0008057_abnormal_DNA_replication0.75570140
146MP0002882_abnormal_neuron_morphology0.75247415
147MP0000432_abnormal_head_morphology0.73563895
148MP0005390_skeleton_phenotype0.73080016
149MP0000427_abnormal_hair_cycle0.72818947
150MP0002063_abnormal_learning/memory/cond0.72750888
151MP0002177_abnormal_outer_ear0.71870775
152MP0002734_abnormal_mechanical_nocicepti0.71525140
153MP0002928_abnormal_bile_duct0.71175928
154MP0003795_abnormal_bone_structure0.70786990
155MP0005620_abnormal_muscle_contractility0.70188509
156MP0001533_abnormal_skeleton_physiology0.68926876
157MP0002234_abnormal_pharynx_morphology0.68552200
158MP0003935_abnormal_craniofacial_develop0.67787831
159MP0002751_abnormal_autonomic_nervous0.67617560
160MP0003121_genomic_imprinting0.67423207
161MP0005551_abnormal_eye_electrophysiolog0.67232551
162MP0005595_abnormal_vascular_smooth0.67163378
163MP0000534_abnormal_ureter_morphology0.67077224
164MP0004185_abnormal_adipocyte_glucose0.64393124

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.53493682
2Arterial tortuosity (HP:0005116)4.19089179
3Vascular tortuosity (HP:0004948)3.97521039
4Abnormality of liposaccharide metabolism (HP:0010968)3.97230576
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.97230576
6Abnormality of glycolipid metabolism (HP:0010969)3.97230576
7Pancreatic fibrosis (HP:0100732)3.58607880
8Abnormality of midbrain morphology (HP:0002418)3.52415767
9Molar tooth sign on MRI (HP:0002419)3.52415767
10True hermaphroditism (HP:0010459)3.52219745
11Pancreatic cysts (HP:0001737)3.46727927
12Epiphyseal dysplasia (HP:0002656)3.19604571
13Neurofibrillary tangles (HP:0002185)3.05280623
14Premature rupture of membranes (HP:0001788)2.97526643
15Inappropriate behavior (HP:0000719)2.94527395
16Subacute progressive viral hepatitis (HP:0006572)2.87794939
17Hypoplastic ischia (HP:0003175)2.83036127
18Absent speech (HP:0001344)2.82933738
19Hypokalemic alkalosis (HP:0001949)2.81067626
20Aortic aneurysm (HP:0004942)2.75466097
21Increased circulating renin level (HP:0000848)2.69478484
22Medial flaring of the eyebrow (HP:0010747)2.66700453
23Aortic dissection (HP:0002647)2.66453432
24Blue irides (HP:0000635)2.66225223
25Abnormality of the ischium (HP:0003174)2.65096732
26Nephronophthisis (HP:0000090)2.63457191
27Gait imbalance (HP:0002141)2.56808187
28Genital tract atresia (HP:0001827)2.56681904
29Vaginal atresia (HP:0000148)2.56317885
30Tubulointerstitial fibrosis (HP:0005576)2.52664779
31Broad ribs (HP:0000885)2.52170606
32Hematochezia (HP:0002573)2.51038976
33Absent frontal sinuses (HP:0002688)2.47292869
34Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.46911828
35Congenital primary aphakia (HP:0007707)2.46890985
36Congenital hepatic fibrosis (HP:0002612)2.45555793
37Febrile seizures (HP:0002373)2.40321520
38Cone-rod dystrophy (HP:0000548)2.38879764
39Abnormality of the renal medulla (HP:0100957)2.38324485
40Drooling (HP:0002307)2.37618895
41Fair hair (HP:0002286)2.35191252
42Tubular atrophy (HP:0000092)2.33662343
43Polyuria (HP:0000103)2.31914732
44Metabolic alkalosis (HP:0200114)2.31686410
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.31277512
46Abnormal ciliary motility (HP:0012262)2.30890005
47Submucous cleft hard palate (HP:0000176)2.29544469
48Metaphyseal dysplasia (HP:0100255)2.29054399
49Abnormality of incisor morphology (HP:0011063)2.28901419
50Generalized hypopigmentation of hair (HP:0011358)2.27168092
51Widely spaced teeth (HP:0000687)2.26892623
52Fibular hypoplasia (HP:0003038)2.26533822
53Abnormality of the nasal septum (HP:0000419)2.24897730
54Cerebral inclusion bodies (HP:0100314)2.24392683
55Abnormality of the frontal sinuses (HP:0002687)2.24390663
56Nephrogenic diabetes insipidus (HP:0009806)2.21598095
57Macroorchidism (HP:0000053)2.20858665
58Abnormal drinking behavior (HP:0030082)2.20570401
59Polydipsia (HP:0001959)2.20570401
60Overgrowth (HP:0001548)2.19586974
61Aplasia/Hypoplasia of the fovea (HP:0008060)2.19339990
62Hypoplasia of the fovea (HP:0007750)2.19339990
63Spondylolisthesis (HP:0003302)2.17630888
64Pulmonary artery stenosis (HP:0004415)2.17472191
65Epidermoid cyst (HP:0200040)2.17356564
66Postaxial foot polydactyly (HP:0001830)2.16815886
67Cystic liver disease (HP:0006706)2.16172001
68Excessive salivation (HP:0003781)2.15019458
69Vacuolated lymphocytes (HP:0001922)2.11224076
70Action tremor (HP:0002345)2.09884611
71Protruding tongue (HP:0010808)2.09415686
72Hyperactive renin-angiotensin system (HP:0000841)2.08739979
73Increased neuronal autofluorescent lipopigment (HP:0002074)2.08556926
74Abnormality of the renal cortex (HP:0011035)2.08539426
75Disinhibition (HP:0000734)2.08498106
76Anencephaly (HP:0002323)2.08035490
77Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.07773644
78Decreased lacrimation (HP:0000633)2.06674061
79Hypoplasia of the iris (HP:0007676)2.04278755
80Abnormality of the right ventricle (HP:0001707)2.03975390
81Abnormality of the fovea (HP:0000493)2.03393297
82Mixed hearing impairment (HP:0000410)2.03239231
83Dynein arm defect of respiratory motile cilia (HP:0012255)2.02802454
84Absent/shortened dynein arms (HP:0200106)2.02802454
85Progressive cerebellar ataxia (HP:0002073)2.02547550
86Increased cerebral lipofuscin (HP:0011813)2.02463632
87Tubulointerstitial abnormality (HP:0001969)2.02105610
88Chronic hepatic failure (HP:0100626)2.01592051
89Occipital encephalocele (HP:0002085)2.00309729
90Papillary thyroid carcinoma (HP:0002895)1.99715013
91Hypoplastic pelvis (HP:0008839)1.99708887
92Atonic seizures (HP:0010819)1.99522408
93Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98157305
94Hyperaldosteronism (HP:0000859)1.98102304
95Abnormal auditory evoked potentials (HP:0006958)1.96137149
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.94885740
97Scapular winging (HP:0003691)1.93585046
98Soft skin (HP:0000977)1.92800374
99Degeneration of the lateral corticospinal tracts (HP:0002314)1.90638473
100Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90638473
101Asymmetry of the thorax (HP:0001555)1.88999009
102Vitreoretinal degeneration (HP:0000655)1.87480796
103Poor coordination (HP:0002370)1.87307315
104Limited elbow extension (HP:0001377)1.87060984
105Rhinitis (HP:0012384)1.84758086
106Neonatal short-limb short stature (HP:0008921)1.84543125
107Aplasia involving bones of the extremities (HP:0009825)1.83936697
108Aplasia involving bones of the upper limbs (HP:0009823)1.83936697
109Aplasia of the phalanges of the hand (HP:0009802)1.83936697
110Short nail (HP:0001799)1.83784701
111Cerebral aneurysm (HP:0004944)1.83778133
112Aplasia/Hypoplasia affecting the retina (HP:0008061)1.82918142
113Cupped ear (HP:0000378)1.82620415
114Abnormal respiratory motile cilium physiology (HP:0012261)1.82052670
115Femoral bowing (HP:0002980)1.81651216
116Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81567394
117Insidious onset (HP:0003587)1.81231745
118Termporal pattern (HP:0011008)1.81231745
119Cervical subluxation (HP:0003308)1.80891212
120Aplasia/Hypoplasia of the macula (HP:0008059)1.80675023
121Bell-shaped thorax (HP:0001591)1.80315237
122Postaxial hand polydactyly (HP:0001162)1.80136848
123Abnormal respiratory epithelium morphology (HP:0012253)1.80073726
124Abnormal respiratory motile cilium morphology (HP:0005938)1.80073726
125Abnormal urine output (HP:0012590)1.80008784
126Shallow orbits (HP:0000586)1.79449399
127Hepatoblastoma (HP:0002884)1.79050646
128Protrusio acetabuli (HP:0003179)1.78303539
129Sclerocornea (HP:0000647)1.78208471
130Agnosia (HP:0010524)1.77704950
131Osteolytic defects of the phalanges of the hand (HP:0009771)1.76889424
132Osteolytic defects of the hand bones (HP:0009699)1.76889424
133Global brain atrophy (HP:0002283)1.76855767
134Wormian bones (HP:0002645)1.76678064
135Alacrima (HP:0000522)1.76006516
136Cranial hyperostosis (HP:0004437)1.75659852
137Natal tooth (HP:0000695)1.75580645
138Exostoses (HP:0100777)1.74907242
139Volvulus (HP:0002580)1.74038429
140Short 4th metacarpal (HP:0010044)1.73170408
141Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.73170408
142Limited hip movement (HP:0008800)1.72931408
143Hypoplastic labia majora (HP:0000059)1.72664096
144Congenital sensorineural hearing impairment (HP:0008527)1.72595961
145Gaze-evoked nystagmus (HP:0000640)1.71992779
146Oculomotor apraxia (HP:0000657)1.71118495
147Short foot (HP:0001773)1.71087679
148Buphthalmos (HP:0000557)1.70818177
149Narrow palate (HP:0000189)1.70421475
150Aqueductal stenosis (HP:0002410)1.70136821
151Furrowed tongue (HP:0000221)1.69479296
152Small epiphyses (HP:0010585)1.69163229
153Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.68921406
154Albinism (HP:0001022)1.68865301
155Narrow forehead (HP:0000341)1.68539010
156Mitral valve prolapse (HP:0001634)1.68418063
157Aplasia/Hypoplasia of the fibula (HP:0006492)1.68389694
158Abnormality of the phalanges of the 2nd finger (HP:0009541)1.68243647
159Retinal atrophy (HP:0001105)1.67971394
160Abnormality of the fibula (HP:0002991)1.67695528
161Cupped ribs (HP:0000887)1.67150491
162Abolished electroretinogram (ERG) (HP:0000550)1.65775935
163Abnormality of chloride homeostasis (HP:0011422)1.65352429
164Abnormal pancreas size (HP:0012094)1.65236030
165Type II lissencephaly (HP:0007260)1.64911433
166Broad-based gait (HP:0002136)1.64183277
167Anophthalmia (HP:0000528)1.64087449
168Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.63796541
169Focal seizures (HP:0007359)1.62551780
170Left ventricular hypertrophy (HP:0001712)1.62519258
171Joint laxity (HP:0001388)1.61388603
172Aplasia/Hypoplasia of the lens (HP:0008063)1.60590052
173Dilatation of the ascending aorta (HP:0005111)1.59320023
174Atrophic scars (HP:0001075)1.57841388
175Micronodular cirrhosis (HP:0001413)1.56960336
176Abnormality of the 2nd finger (HP:0004100)1.55634290
177Craniofacial hyperostosis (HP:0004493)1.54532793
178Abnormal foot bone ossification (HP:0010675)1.53168810
179Progressive visual loss (HP:0000529)1.52840031
180Abnormality of the labia majora (HP:0012881)1.52609024
181Follicular hyperkeratosis (HP:0007502)1.52385657
182Pectus carinatum (HP:0000768)1.51791092
183Delayed closure of the anterior fontanelle (HP:0001476)1.51454994
184Abnormality of dentin (HP:0010299)1.51264389
185Mild short stature (HP:0003502)1.49745692
186Segmental peripheral demyelination/remyelination (HP:0003481)1.48969996
187Neoplasm of the adrenal cortex (HP:0100641)1.48765029
188Short clavicles (HP:0000894)1.48586855
189Tarsal synostosis (HP:0008368)1.48507332

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.82388331
2ACVR1B3.70426151
3FGFR23.13811014
4MET2.71309720
5PBK2.70310946
6LATS12.60623900
7PNCK2.58469474
8STK392.48198057
9BCR2.37774945
10TNIK2.31467686
11NUAK12.14182161
12MARK12.05091648
13WNK31.96347935
14INSRR1.93266156
15CAMK1G1.82244434
16SIK11.81981022
17STK31.74788993
18DDR21.72691342
19ADRBK21.72063671
20CAMK1D1.69231716
21MST1R1.65763278
22PTK61.65489303
23TTN1.60592550
24MST41.59534312
25MAP3K141.52419296
26PIK3CA1.49897068
27TRPM71.47560810
28FER1.46900861
29WNK41.43278805
30PINK11.41946679
31TIE11.40752559
32NTRK31.40180544
33MAP4K21.38672035
34WNK11.34202409
35PKN11.32982346
36TGFBR21.31012449
37TGFBR11.29385170
38MARK31.26734714
39ERBB31.26614741
40PAK31.26007866
41OXSR11.25260857
42NTRK21.23435399
43PDGFRB1.22504189
44MAPK151.19192057
45CSNK1A1L1.18883870
46PLK21.17539268
47AKT31.15650861
48SGK4941.12903631
49SGK2231.12903631
50PTK2B1.11203313
51CAMKK21.10702559
52EPHA41.10396672
53NEK61.10319252
54TRIM281.08854793
55DAPK21.06131608
56MKNK21.04055284
57PDK21.02971502
58DMPK0.98313936
59OBSCN0.98233375
60NEK90.97023344
61JAK10.96857388
62MAPK130.96424778
63PDGFRA0.94843627
64LIMK10.93078101
65NLK0.91445421
66MATK0.90533612
67BMPR1B0.85440455
68EPHA30.84037458
69PRKCE0.83754904
70BLK0.83193565
71FGFR30.80676436
72BRD40.79987611
73MELK0.79276941
74STK38L0.79076050
75ROCK10.77682006
76SGK20.77306502
77MAP3K20.75857657
78FGFR10.74835052
79CSNK1G20.73824058
80SGK30.73518721
81YES10.73460113
82ITK0.73349314
83CSNK1G10.71876376
84NTRK10.71795874
85* INSR0.71116796
86KSR10.70582497
87STK240.69792824
88MAP2K40.67546501
89MKNK10.66683338
90MAP3K40.66459534
91EPHB20.65113506
92ERBB20.63636468
93RET0.63590716
94FGR0.63421629
95DYRK1A0.63256619
96TYRO30.62670865
97RIPK40.62581948
98GRK10.62356471
99IRAK30.60897398
100PRKCQ0.60550325
101PRKAA20.59584769
102PRKG10.59221595
103WEE10.59158677
104IGF1R0.58004731
105RIPK10.56810261
106GRK70.56800748
107PRKACB0.56689666
108PRKD10.55395122
109SGK10.55381010
110PTK20.54856668
111PRKCG0.54035796
112BMX0.52207818
113CAMK2D0.51953119
114CDK60.51915854
115CASK0.51047626
116CAMK2A0.49793473
117CDC42BPA0.49729545
118BMPR20.49423920
119GSK3A0.49319648
120ZAK0.49029496
121ROCK20.48326667
122RPS6KB10.47298530
123PRKCH0.46611442
124CSK0.46506961
125MAP2K70.46362430
126TYK20.46163375
127CHUK0.45526784
128EGFR0.45466438
129STK110.42981762
130BRSK20.42460817
131FYN0.42109269
132TAOK30.41804516
133STK100.41734254
134ABL10.40878171
135SRC0.40592946
136EPHB10.40556347
137CAMK2B0.40396998
138IRAK10.39395066
139CSNK1G30.39310970
140CDK30.39261383
141MAP3K70.38771503
142IRAK20.37482135

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.11848054
2ECM-receptor interaction_Homo sapiens_hsa045121.84976386
3Primary bile acid biosynthesis_Homo sapiens_hsa001201.81597748
4Histidine metabolism_Homo sapiens_hsa003401.67488311
5Rheumatoid arthritis_Homo sapiens_hsa053231.59083756
6Collecting duct acid secretion_Homo sapiens_hsa049661.55262264
7Focal adhesion_Homo sapiens_hsa045101.53767934
8Malaria_Homo sapiens_hsa051441.52504207
9Phagosome_Homo sapiens_hsa041451.48428968
10Lysosome_Homo sapiens_hsa041421.47688226
11Fatty acid biosynthesis_Homo sapiens_hsa000611.47261692
12Nicotine addiction_Homo sapiens_hsa050331.42389907
13Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.39984315
14ABC transporters_Homo sapiens_hsa020101.35435763
15Axon guidance_Homo sapiens_hsa043601.34789057
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28660724
17Sulfur metabolism_Homo sapiens_hsa009201.27845409
18Proteoglycans in cancer_Homo sapiens_hsa052051.27660292
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.26777852
20Nitrogen metabolism_Homo sapiens_hsa009101.26132291
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25374387
22Vibrio cholerae infection_Homo sapiens_hsa051101.24992531
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24158712
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23899962
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21841283
26Adherens junction_Homo sapiens_hsa045201.21510302
27Type II diabetes mellitus_Homo sapiens_hsa049301.21166419
28Dilated cardiomyopathy_Homo sapiens_hsa054141.21166274
29Renal cell carcinoma_Homo sapiens_hsa052111.19475364
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19285611
31Taste transduction_Homo sapiens_hsa047421.18755048
32Mineral absorption_Homo sapiens_hsa049781.17312459
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16792152
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13065923
35Renin secretion_Homo sapiens_hsa049241.12882795
36Other glycan degradation_Homo sapiens_hsa005111.10904530
37Dorso-ventral axis formation_Homo sapiens_hsa043201.07871995
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06942593
39Prostate cancer_Homo sapiens_hsa052151.00888554
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00604767
41Ether lipid metabolism_Homo sapiens_hsa005651.00592804
42Legionellosis_Homo sapiens_hsa051340.99091755
43Dopaminergic synapse_Homo sapiens_hsa047280.97736880
44Phototransduction_Homo sapiens_hsa047440.96919707
45Osteoclast differentiation_Homo sapiens_hsa043800.92947196
46Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92550249
47Amoebiasis_Homo sapiens_hsa051460.92000113
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.91919465
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.91238969
50Melanoma_Homo sapiens_hsa052180.90666071
51MicroRNAs in cancer_Homo sapiens_hsa052060.88862088
52Viral myocarditis_Homo sapiens_hsa054160.88845476
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88416431
54Long-term depression_Homo sapiens_hsa047300.88352584
55Staphylococcus aureus infection_Homo sapiens_hsa051500.88218523
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87873043
57Ras signaling pathway_Homo sapiens_hsa040140.86490358
58Selenocompound metabolism_Homo sapiens_hsa004500.85308505
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85186255
60Tryptophan metabolism_Homo sapiens_hsa003800.84555753
61PPAR signaling pathway_Homo sapiens_hsa033200.84355428
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84266018
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.83559486
64Hedgehog signaling pathway_Homo sapiens_hsa043400.83365709
65Salmonella infection_Homo sapiens_hsa051320.83297734
66Ovarian steroidogenesis_Homo sapiens_hsa049130.83237090
67Linoleic acid metabolism_Homo sapiens_hsa005910.83107474
68TNF signaling pathway_Homo sapiens_hsa046680.82964526
69Inositol phosphate metabolism_Homo sapiens_hsa005620.82437995
70Protein digestion and absorption_Homo sapiens_hsa049740.81973610
71* TGF-beta signaling pathway_Homo sapiens_hsa043500.81735329
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80942993
73Hippo signaling pathway_Homo sapiens_hsa043900.80654786
74ErbB signaling pathway_Homo sapiens_hsa040120.80260044
75* Endocytosis_Homo sapiens_hsa041440.79057409
76Toxoplasmosis_Homo sapiens_hsa051450.78794686
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77729170
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77320306
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77315768
80Sphingolipid metabolism_Homo sapiens_hsa006000.76691292
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76554043
82Small cell lung cancer_Homo sapiens_hsa052220.76366592
83Serotonergic synapse_Homo sapiens_hsa047260.76273875
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76269053
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.76182184
86Basal cell carcinoma_Homo sapiens_hsa052170.75859236
87Platelet activation_Homo sapiens_hsa046110.75667587
88Tuberculosis_Homo sapiens_hsa051520.75545846
89Circadian entrainment_Homo sapiens_hsa047130.75372271
90Butanoate metabolism_Homo sapiens_hsa006500.75311368
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75301430
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.74643175
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74423055
94Tight junction_Homo sapiens_hsa045300.74300578
95Morphine addiction_Homo sapiens_hsa050320.74204662
96GABAergic synapse_Homo sapiens_hsa047270.73440361
97Chemokine signaling pathway_Homo sapiens_hsa040620.73312760
98Cocaine addiction_Homo sapiens_hsa050300.70814347
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.68313873
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66814461
101Leishmaniasis_Homo sapiens_hsa051400.66497036
102Rap1 signaling pathway_Homo sapiens_hsa040150.66396312
103MAPK signaling pathway_Homo sapiens_hsa040100.66033228
104Pancreatic cancer_Homo sapiens_hsa052120.66024623
105Salivary secretion_Homo sapiens_hsa049700.65917966
106Steroid biosynthesis_Homo sapiens_hsa001000.65799068
107Olfactory transduction_Homo sapiens_hsa047400.65772126
108Choline metabolism in cancer_Homo sapiens_hsa052310.64901424
109Estrogen signaling pathway_Homo sapiens_hsa049150.64315300
110Synaptic vesicle cycle_Homo sapiens_hsa047210.63737349
111Pathways in cancer_Homo sapiens_hsa052000.63580028
112cAMP signaling pathway_Homo sapiens_hsa040240.63347475
113Propanoate metabolism_Homo sapiens_hsa006400.63343526
114Cholinergic synapse_Homo sapiens_hsa047250.63198480
115FoxO signaling pathway_Homo sapiens_hsa040680.63108777
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62995690
117Insulin secretion_Homo sapiens_hsa049110.62285499
118Insulin resistance_Homo sapiens_hsa049310.62278341
119Gastric acid secretion_Homo sapiens_hsa049710.62220030
120Complement and coagulation cascades_Homo sapiens_hsa046100.62042640
121Renin-angiotensin system_Homo sapiens_hsa046140.61652495
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61609021
123Glutamatergic synapse_Homo sapiens_hsa047240.61448469
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61433324
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59705865
126Glioma_Homo sapiens_hsa052140.59666666
127B cell receptor signaling pathway_Homo sapiens_hsa046620.58995194
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58827375
129Melanogenesis_Homo sapiens_hsa049160.58597371
130Wnt signaling pathway_Homo sapiens_hsa043100.57691150
131Oxytocin signaling pathway_Homo sapiens_hsa049210.57603765
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57489049
133Circadian rhythm_Homo sapiens_hsa047100.57024774
134Calcium signaling pathway_Homo sapiens_hsa040200.56052739
135Pertussis_Homo sapiens_hsa051330.54852284
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54225601
137Bile secretion_Homo sapiens_hsa049760.54032143
138Amphetamine addiction_Homo sapiens_hsa050310.49604649
139GnRH signaling pathway_Homo sapiens_hsa049120.48424515
140Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47832108
141beta-Alanine metabolism_Homo sapiens_hsa004100.47386379
142Regulation of autophagy_Homo sapiens_hsa041400.46325035

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