ZFYVE19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingosine metabolic process (GO:0006670)8.93554107
2diol metabolic process (GO:0034311)8.39089668
3aminoglycoside antibiotic metabolic process (GO:0030647)7.43377212
4sphingoid metabolic process (GO:0046519)6.87947194
5maintenance of protein location in nucleus (GO:0051457)6.03767218
6protein localization to kinetochore (GO:0034501)5.85532471
7regulation of mammary gland epithelial cell proliferation (GO:0033599)5.62683451
8regulation of nuclear cell cycle DNA replication (GO:0033262)5.50556356
9lipopolysaccharide biosynthetic process (GO:0009103)5.35609810
10rRNA transcription (GO:0009303)5.31548365
11negative regulation of epidermis development (GO:0045683)5.31150818
12somite rostral/caudal axis specification (GO:0032525)5.22811295
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.12200026
14L-phenylalanine metabolic process (GO:0006558)5.12200026
15regulation of response to osmotic stress (GO:0047484)5.10520278
16negative regulation of glycoprotein biosynthetic process (GO:0010561)4.97248814
17lipopolysaccharide metabolic process (GO:0008653)4.91843999
18DNA methylation involved in gamete generation (GO:0043046)4.90113702
19regulation of telomere maintenance via telomerase (GO:0032210)4.81073454
20negative regulation of telomerase activity (GO:0051974)4.70628778
21quinone metabolic process (GO:1901661)4.70578645
22NIK/NF-kappaB signaling (GO:0038061)4.69944604
23rRNA methylation (GO:0031167)4.69253049
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.64749776
25L-phenylalanine catabolic process (GO:0006559)4.64749776
26regulation of cilium movement (GO:0003352)4.60317860
27rRNA modification (GO:0000154)4.58315729
28histone H4-K5 acetylation (GO:0043981)4.53391529
29histone H4-K8 acetylation (GO:0043982)4.53391529
30cytidine deamination (GO:0009972)4.51213466
31cytidine metabolic process (GO:0046087)4.51213466
32cytidine catabolic process (GO:0006216)4.51213466
33mitotic sister chromatid segregation (GO:0000070)4.47986615
34negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.41608388
35regulation of translation in response to stress (GO:0043555)4.41151868
36GDP-mannose metabolic process (GO:0019673)4.40906878
37protein localization to chromosome, centromeric region (GO:0071459)4.36237343
38coenzyme catabolic process (GO:0009109)4.35627347
39cullin deneddylation (GO:0010388)4.35206836
40DNA replication checkpoint (GO:0000076)4.34669888
41protein retention in ER lumen (GO:0006621)4.32569138
42muscle organ morphogenesis (GO:0048644)4.31195010
43histone H4-K12 acetylation (GO:0043983)4.30714252
44interferon-gamma production (GO:0032609)4.26728881
45negative regulation of epidermal cell differentiation (GO:0045605)4.25006530
46regulation of MHC class I biosynthetic process (GO:0045343)4.20573576
47negative regulation of glycoprotein metabolic process (GO:1903019)4.18989463
48positive regulation of DNA-dependent DNA replication (GO:2000105)4.16316410
49protein deneddylation (GO:0000338)4.14665925
50nucleoside transmembrane transport (GO:1901642)4.14534678
51pseudouridine synthesis (GO:0001522)4.10868494
52negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.08347819
53ribosomal small subunit biogenesis (GO:0042274)4.06284201
54formation of translation preinitiation complex (GO:0001731)4.05381964
55negative regulation of telomere maintenance (GO:0032205)4.02799062
56maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.93119784
57DNA replication-dependent nucleosome organization (GO:0034723)3.90822984
58DNA replication-dependent nucleosome assembly (GO:0006335)3.90822984
59primitive streak formation (GO:0090009)3.86446929
60DNA damage response, detection of DNA damage (GO:0042769)3.80660942
61regulation of apoptotic process involved in morphogenesis (GO:1902337)3.79909278
62sister chromatid segregation (GO:0000819)3.72480905
63ribosome biogenesis (GO:0042254)3.71750085
64phenol-containing compound catabolic process (GO:0019336)3.70081830
65positive regulation of triglyceride lipase activity (GO:0061365)3.65857695
66positive regulation of lipoprotein lipase activity (GO:0051006)3.65857695
67hormone catabolic process (GO:0042447)3.63893228
68response to dietary excess (GO:0002021)3.60143389
69maintenance of protein localization in organelle (GO:0072595)3.59146029
70Golgi transport vesicle coating (GO:0048200)3.57145277
71COPI coating of Golgi vesicle (GO:0048205)3.57145277
72mannose metabolic process (GO:0006013)3.54112411
73positive regulation of Cdc42 GTPase activity (GO:0043089)3.51048205
74germinal center formation (GO:0002467)3.45733670
75piRNA metabolic process (GO:0034587)3.44774532
76heterochromatin organization (GO:0070828)3.44278986
77transcription from mitochondrial promoter (GO:0006390)3.44028095
78cellular modified amino acid catabolic process (GO:0042219)3.42905033
79mitochondrial DNA replication (GO:0006264)3.42323079
80protein-chromophore linkage (GO:0018298)3.41837806
81DNA unwinding involved in DNA replication (GO:0006268)3.38051947
82regulation of telomerase activity (GO:0051972)3.34855631
83pteridine-containing compound biosynthetic process (GO:0042559)3.32106990
84glycosphingolipid catabolic process (GO:0046479)3.27826976
85sulfate transmembrane transport (GO:1902358)3.27068164
86pyrimidine ribonucleoside catabolic process (GO:0046133)3.25999343
87ribonucleoprotein complex biogenesis (GO:0022613)3.23356471
88response to thyroid hormone (GO:0097066)3.22856423
89mitochondrion distribution (GO:0048311)3.22192420
90histone H4-K16 acetylation (GO:0043984)3.20915007
91regulation of superoxide anion generation (GO:0032928)3.20196061
92negative regulation of erythrocyte differentiation (GO:0045647)3.15535389
93positive regulation of protein deacetylation (GO:0090312)3.10378200
94protein maturation by protein folding (GO:0022417)3.09889613
95proline biosynthetic process (GO:0006561)3.09221882
96chromatin assembly (GO:0031497)3.06752887
97retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.04613766
98protein polyglutamylation (GO:0018095)3.03599139
99primary alcohol catabolic process (GO:0034310)3.01891046
100cellular response to thyroid hormone stimulus (GO:0097067)3.01313619
101regulation of microtubule-based movement (GO:0060632)2.96707343
102apoptotic DNA fragmentation (GO:0006309)2.96366457
103DNA replication initiation (GO:0006270)2.94835350
104nucleoside transport (GO:0015858)2.94192717
105cofactor transport (GO:0051181)2.94126665
106negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.93933681
107mitotic chromosome condensation (GO:0007076)2.93489691
108negative regulation of phagocytosis (GO:0050765)2.92708565
109glycolipid catabolic process (GO:0019377)2.91714336
110activation of Rac GTPase activity (GO:0032863)2.91549747
111flavonoid metabolic process (GO:0009812)2.91047699
112branching involved in mammary gland duct morphogenesis (GO:0060444)2.88143095
113cellular component biogenesis (GO:0044085)2.87451342
114microtubule severing (GO:0051013)2.87162655
115tyrosine metabolic process (GO:0006570)2.86319464
116cell fate commitment involved in formation of primary germ layer (GO:0060795)2.84911731
117DNA duplex unwinding (GO:0032508)2.82730754
118negative regulation of interleukin-2 production (GO:0032703)2.80884293
119heme transport (GO:0015886)2.79859200
120notochord development (GO:0030903)2.79633333
121* negative regulation of cell cycle G2/M phase transition (GO:1902750)2.79313488
122DNA geometric change (GO:0032392)2.77892927
123positive regulation of defense response to virus by host (GO:0002230)2.77566108
124intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.77146373
125cardiovascular system development (GO:0072358)2.76697767
126regulation of ARF GTPase activity (GO:0032312)2.75753597
127endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.73585422
128regulation of telomere maintenance (GO:0032204)2.73422029
129cofactor catabolic process (GO:0051187)2.72078327
130nuclear pore complex assembly (GO:0051292)2.71076285
131amyloid precursor protein catabolic process (GO:0042987)2.70452160
132* negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.70255542
133regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.69210099
134maternal placenta development (GO:0001893)2.69089555
135epoxygenase P450 pathway (GO:0019373)2.67736352
136sulfate transport (GO:0008272)2.67237316
137retinoic acid receptor signaling pathway (GO:0048384)2.66870038
138positive regulation of gluconeogenesis (GO:0045722)2.65627480
139mitochondrial DNA metabolic process (GO:0032042)2.64813406
140thyroid hormone generation (GO:0006590)2.63065078
141pinocytosis (GO:0006907)2.63011783
142positive regulation of developmental pigmentation (GO:0048087)2.62736554
143protein localization to endosome (GO:0036010)2.60946563
144neutrophil activation involved in immune response (GO:0002283)2.57765754
145phospholipid efflux (GO:0033700)2.57656879
146purine deoxyribonucleotide catabolic process (GO:0009155)2.56675671
147barbed-end actin filament capping (GO:0051016)2.55010687
148glucose 6-phosphate metabolic process (GO:0051156)2.54578873
149protein-lipid complex assembly (GO:0065005)2.53556737
150ribonucleoprotein complex disassembly (GO:0032988)2.52674221
151plasma lipoprotein particle assembly (GO:0034377)2.52034229
152galactose metabolic process (GO:0006012)2.51882878
153positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.51878619
154regulation of cholesterol esterification (GO:0010872)2.46378427
155regulation of triglyceride catabolic process (GO:0010896)2.45925201
156regulation of retinoic acid receptor signaling pathway (GO:0048385)2.42835767
157positive regulation of triglyceride metabolic process (GO:0090208)2.41730708
158ceramide catabolic process (GO:0046514)2.41230011
159regulation of necrotic cell death (GO:0010939)2.40741100
160modulation by symbiont of host immune response (GO:0052553)2.39032770
161positive regulation by symbiont of host defense response (GO:0052509)2.39032770
162modulation by symbiont of host defense response (GO:0052031)2.39032770
163modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.39032770
164modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.39032770
165positive regulation by organism of defense response of other organism involved in symbiotic interact2.39032770
166regulation of necroptotic process (GO:0060544)2.38823742
167response to mercury ion (GO:0046689)2.37593071
168embryonic process involved in female pregnancy (GO:0060136)2.32808734
169SMAD protein complex assembly (GO:0007183)2.32102819
170virion assembly (GO:0019068)2.31890771
171regulation of extracellular matrix disassembly (GO:0010715)2.29797709
172regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.28929079
173proline metabolic process (GO:0006560)2.28380680
174trivalent inorganic anion homeostasis (GO:0072506)2.28349627
175phosphate ion homeostasis (GO:0055062)2.28349627
176regulation of protein glycosylation (GO:0060049)2.27670541
177ncRNA 3-end processing (GO:0043628)2.27110661
178negative regulation of stem cell proliferation (GO:2000647)2.27028121
179very-low-density lipoprotein particle assembly (GO:0034379)2.26419606
180positive regulation of pseudopodium assembly (GO:0031274)2.26128462
181amyloid precursor protein metabolic process (GO:0042982)2.25498593
182regulation of early endosome to late endosome transport (GO:2000641)2.23718174
183negative regulation of fatty acid biosynthetic process (GO:0045717)2.22410582
184regulation of translational termination (GO:0006449)2.22167436
185regulation of meiosis I (GO:0060631)2.21846711
186urea cycle (GO:0000050)2.21016009
187positive regulation of regulated secretory pathway (GO:1903307)2.17738564
188regulation of interleukin-5 production (GO:0032674)2.16846865
189positive regulation of histone acetylation (GO:0035066)2.15854094
190stress fiber assembly (GO:0043149)2.15468883
191signal complex assembly (GO:0007172)2.13655923
192amino sugar catabolic process (GO:0046348)2.11337390
193response to peptidoglycan (GO:0032494)2.11101717
194transferrin transport (GO:0033572)2.10322109
195daunorubicin metabolic process (GO:0044597)11.3079256
196polyketide metabolic process (GO:0030638)11.3079256
197doxorubicin metabolic process (GO:0044598)11.3079256

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.66207362
2E2F7_22180533_ChIP-Seq_HELA_Human4.72363689
3* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.71282784
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.28149989
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.28149989
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.28149989
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86731161
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80392756
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.72763837
10VDR_21846776_ChIP-Seq_THP-1_Human2.62783065
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62189479
12LXR_22292898_ChIP-Seq_THP-1_Human2.60823318
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.33258433
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.32179262
15* EST1_17652178_ChIP-ChIP_JURKAT_Human2.31635229
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30825887
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.27422687
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27224517
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24290904
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.22760699
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17919306
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.12997871
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12098411
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10545378
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08820030
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05107799
27ELK3_25401928_ChIP-Seq_HUVEC_Human2.05104344
28ZNF263_19887448_ChIP-Seq_K562_Human2.04049372
29YY1_21170310_ChIP-Seq_MESCs_Mouse2.03285536
30GABP_17652178_ChIP-ChIP_JURKAT_Human2.02351961
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96492182
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.96374082
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.92396698
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90374580
35SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.88078064
36RACK7_27058665_Chip-Seq_MCF-7_Human1.87219027
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.84479786
38SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.83391328
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82190759
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79578937
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.76904551
42IRF1_19129219_ChIP-ChIP_H3396_Human1.75167222
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.75111671
44P68_20966046_ChIP-Seq_HELA_Human1.74672487
45FOXP3_21729870_ChIP-Seq_TREG_Human1.72663032
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71365722
47BCOR_27268052_Chip-Seq_Bcells_Human1.66693567
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65503090
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62139915
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58608464
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.57896302
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57665854
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56602192
54TCF3_18692474_ChIP-Seq_MEFs_Mouse1.56467213
55NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.55318435
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54299774
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.54000562
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53787261
59TCF3_18692474_ChIP-Seq_MESCs_Mouse1.52976411
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.52458003
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51826492
62BCL6_27268052_Chip-Seq_Bcells_Human1.51641979
63VDR_24763502_ChIP-Seq_THP-1_Human1.51607059
64MYC_22102868_ChIP-Seq_BL_Human1.51534098
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50720789
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.50654477
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.50547799
68SCL_19346495_ChIP-Seq_HPC-7_Human1.49753943
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48561139
70XRN2_22483619_ChIP-Seq_HELA_Human1.47504741
71SMC4_20622854_ChIP-Seq_HELA_Human1.46757583
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46217876
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44328582
74VDR_23849224_ChIP-Seq_CD4+_Human1.42459709
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41573685
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40942435
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40477895
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39081099
79GABP_19822575_ChIP-Seq_HepG2_Human1.38829762
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38458957
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37302840
82E2F1_20622854_ChIP-Seq_HELA_Human1.37174781
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.36941136
84* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35871741
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35582497
86RXR_22158963_ChIP-Seq_LIVER_Mouse1.34577801
87PPARA_22158963_ChIP-Seq_LIVER_Mouse1.33976087
88TCF7_22412390_ChIP-Seq_EML_Mouse1.31480418
89PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29902784
90KDM2B_26808549_Chip-Seq_DND41_Human1.28258374
91* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28094606
92* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27540281
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27225870
94CTCF_26484167_Chip-Seq_Bcells_Mouse1.26360730
95ATF3_27146783_Chip-Seq_COLON_Human1.26138427
96MAF_26560356_Chip-Seq_TH2_Human1.26033974
97* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25621393
98RUNX1_22412390_ChIP-Seq_EML_Mouse1.24583330
99PHF8_20622854_ChIP-Seq_HELA_Human1.23658503
100STAT1_20625510_ChIP-Seq_HELA_Human1.22227762
101E2F1_17053090_ChIP-ChIP_MCF-7_Human1.22208882
102UTX_26944678_Chip-Seq_JUKART_Human1.21442823
103CTCF_18555785_ChIP-Seq_MESCs_Mouse1.20958707
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20613813
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20345169
106SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18971560
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18817826
108RARB_24833708_ChIP-Seq_LIVER_Mouse1.16952131
109IRF8_22096565_ChIP-ChIP_GC-B_Human1.15998665
110NCOR1_26117541_ChIP-Seq_K562_Human1.15818613
111* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.15746133
112DCP1A_22483619_ChIP-Seq_HELA_Human1.15100417
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15014288
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14507956
115STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14503135
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14234675
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13934138
118POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.13323954
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12752526
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12721515
121MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12357872
122RARA_24833708_ChIP-Seq_LIVER_Mouse1.11695880
123* SRF_21415370_ChIP-Seq_HL-1_Mouse1.10433402
124OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10298293
125TTF2_22483619_ChIP-Seq_HELA_Human1.10266161
126SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10108575
127ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09659795
128NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09648500
129CIITA_25753668_ChIP-Seq_RAJI_Human1.09334375
130EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09170859
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08665099
132SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08600907
133* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07843258
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07838384
135MAF_26560356_Chip-Seq_TH1_Human1.06859877
136SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06749097
137ESR2_21235772_ChIP-Seq_MCF-7_Human1.06464266
138BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05425529
139GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05406332
140CREB1_26743006_Chip-Seq_LNCaP_Human1.04842131
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04731800
142PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04390585
143GATA1_19941827_ChIP-Seq_MEL_Mouse1.03998779
144KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03910499
145P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03818194
146* FOXP1_21924763_ChIP-Seq_HESCs_Human1.02636077
147HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02106156
148RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01456050
149KDM5A_27292631_Chip-Seq_BREAST_Human1.01264484
150NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01042182
151CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00351279
152TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99707724
153IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99627411
154POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98024976
155* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97440566
156* SPI1_23547873_ChIP-Seq_NB4_Human0.95332560
157SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94013485
158MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93332934
159YY1_22570637_ChIP-Seq_MALME-3M_Human0.93197776
160SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89835866
161ELK1_22589737_ChIP-Seq_MCF10A_Human0.89755977
162* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89082576
163HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88171234
164SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88112023
165NANOG_18692474_ChIP-Seq_MESCs_Mouse0.88073393
166SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87903302
167RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87431914
168KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86615678
169SOX2_18692474_ChIP-Seq_MESCs_Mouse0.85766266
170ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83170232
171YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81967169
172TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.81917625
173NANOG_16153702_ChIP-ChIP_HESCs_Human0.81478368
174BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80491018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.02611747
2MP0003011_delayed_dark_adaptation4.72358961
3MP0004264_abnormal_extraembryonic_tissu4.59627045
4MP0006292_abnormal_olfactory_placode4.53380055
5MP0005075_abnormal_melanosome_morpholog4.46824886
6MP0005058_abnormal_lysosome_morphology4.05125551
7MP0009840_abnormal_foam_cell3.78337105
8MP0008057_abnormal_DNA_replication3.64295344
9MP0005171_absent_coat_pigmentation3.63936756
10MP0003136_yellow_coat_color3.60895417
11MP0002254_reproductive_system_inflammat3.32411954
12MP0004957_abnormal_blastocyst_morpholog3.20310100
13MP0006035_abnormal_mitochondrial_morpho3.09912355
14MP0003890_abnormal_embryonic-extraembry3.06839302
15MP0008260_abnormal_autophagy2.95392625
16MP0003879_abnormal_hair_cell2.95010689
17MP0005394_taste/olfaction_phenotype2.93480267
18MP0005499_abnormal_olfactory_system2.93480267
19MP0003122_maternal_imprinting2.91884605
20MP0005451_abnormal_body_composition2.62612916
21MP0004858_abnormal_nervous_system2.61898392
22MP0003045_fibrosis2.58166400
23MP0002396_abnormal_hematopoietic_system2.57268869
24MP0005365_abnormal_bile_salt2.49635464
25MP0002138_abnormal_hepatobiliary_system2.47077439
26MP0002332_abnormal_exercise_endurance2.41667310
27MP0003191_abnormal_cellular_cholesterol2.37592481
28MP0003121_genomic_imprinting2.22347956
29MP0005085_abnormal_gallbladder_physiolo2.12816822
30MP0003077_abnormal_cell_cycle2.08313852
31MP0003436_decreased_susceptibility_to2.04623123
32MP0005360_urolithiasis2.01547262
33MP0000678_abnormal_parathyroid_gland2.00517974
34MP0003183_abnormal_peptide_metabolism2.00257184
35MP0005257_abnormal_intraocular_pressure1.94264076
36MP0003646_muscle_fatigue1.86546677
37MP0002653_abnormal_ependyma_morphology1.85376811
38MP0005670_abnormal_white_adipose1.79273305
39MP0003300_gastrointestinal_ulcer1.78153091
40MP0010094_abnormal_chromosome_stability1.75233143
41MP0005330_cardiomyopathy1.70185018
42MP0005266_abnormal_metabolism1.69095402
43MP0006082_CNS_inflammation1.63991081
44MP0003693_abnormal_embryo_hatching1.62902157
45MP0006036_abnormal_mitochondrial_physio1.62807138
46MP0004233_abnormal_muscle_weight1.60622022
47MP0003806_abnormal_nucleotide_metabolis1.60394957
48MP0005380_embryogenesis_phenotype1.56222689
49MP0001672_abnormal_embryogenesis/_devel1.56222689
50MP0006054_spinal_hemorrhage1.53199989
51MP0003123_paternal_imprinting1.53010812
52MP0002088_abnormal_embryonic_growth/wei1.52161446
53MP0003984_embryonic_growth_retardation1.51418998
54MP0000490_abnormal_crypts_of1.49125549
55MP0005464_abnormal_platelet_physiology1.48016290
56MP0003938_abnormal_ear_development1.42097469
57MP0002132_abnormal_respiratory_system1.39755821
58MP0000350_abnormal_cell_proliferation1.38941569
59MP0002277_abnormal_respiratory_mucosa1.38697360
60MP0010352_gastrointestinal_tract_polyps1.37720290
61MP0003111_abnormal_nucleus_morphology1.35792254
62MP0003453_abnormal_keratinocyte_physiol1.35428172
63MP0002139_abnormal_hepatobiliary_system1.32241279
64MP0005025_abnormal_response_to1.32001812
65MP0005387_immune_system_phenotype1.30231355
66MP0001790_abnormal_immune_system1.30231355
67MP0001293_anophthalmia1.28051022
68MP0002877_abnormal_melanocyte_morpholog1.27543522
69MP0010155_abnormal_intestine_physiology1.26977214
70MP0002127_abnormal_cardiovascular_syste1.26855181
71MP0005076_abnormal_cell_differentiation1.26512941
72MP0004043_abnormal_pH_regulation1.24584341
73MP0008932_abnormal_embryonic_tissue1.23715742
74MP0002419_abnormal_innate_immunity1.23054688
75MP0004381_abnormal_hair_follicle1.22441637
76MP0000313_abnormal_cell_death1.21940019
77MP0000858_altered_metastatic_potential1.21333782
78MP0000358_abnormal_cell_content/1.19860788
79MP0008789_abnormal_olfactory_epithelium1.17112964
80MP0002452_abnormal_antigen_presenting1.15983908
81MP0008961_abnormal_basal_metabolism1.14968632
82MP0003186_abnormal_redox_activity1.14590739
83MP0001849_ear_inflammation1.13757044
84MP0008007_abnormal_cellular_replicative1.12122954
85MP0002148_abnormal_hypersensitivity_rea1.09790167
86MP0002932_abnormal_joint_morphology1.09479226
87MP0002075_abnormal_coat/hair_pigmentati1.07833056
88MP0002420_abnormal_adaptive_immunity1.07478070
89MP0002723_abnormal_immune_serum1.06904900
90MP0001819_abnormal_immune_cell1.04445908
91MP0002092_abnormal_eye_morphology1.03918937
92MP0002970_abnormal_white_adipose1.03789066
93MP0008469_abnormal_protein_level1.03506158
94MP0008874_decreased_physiological_sensi1.02406407
95MP0002168_other_aberrant_phenotype1.00853202
96MP0003329_amyloid_beta_deposits0.99247607
97MP0002086_abnormal_extraembryonic_tissu0.98997012
98MP0000015_abnormal_ear_pigmentation0.98569722
99MP0005083_abnormal_biliary_tract0.98461745
100MP0000689_abnormal_spleen_morphology0.96915058
101MP0001845_abnormal_inflammatory_respons0.96261378
102MP0005000_abnormal_immune_tolerance0.95644580
103MP0000604_amyloidosis0.95149045
104MP0003786_premature_aging0.94589134
105MP0003763_abnormal_thymus_physiology0.94477100
106MP0009278_abnormal_bone_marrow0.94151008
107MP0005319_abnormal_enzyme/_coenzyme0.94123256
108MP0003075_altered_response_to0.91309873
109MP0002722_abnormal_immune_system0.90053112
110MP0001730_embryonic_growth_arrest0.89960974
111MP0009785_altered_susceptibility_to0.89328476
112MP0001186_pigmentation_phenotype0.89080801
113MP0002085_abnormal_embryonic_tissue0.88894016
114MP0008058_abnormal_DNA_repair0.86920333
115MP0003705_abnormal_hypodermis_morpholog0.86507542
116MP0002751_abnormal_autonomic_nervous0.85881328
117MP0003315_abnormal_perineum_morphology0.85285910
118MP0009333_abnormal_splenocyte_physiolog0.85242259
119MP0000049_abnormal_middle_ear0.85214225
120MP0002080_prenatal_lethality0.85141020
121MP0000749_muscle_degeneration0.84631574
122MP0002429_abnormal_blood_cell0.84385684
123MP0005501_abnormal_skin_physiology0.84215740
124MP0001348_abnormal_lacrimal_gland0.83933046
125MP0005671_abnormal_response_to0.83626455
126MP0010329_abnormal_lipoprotein_level0.83398138
127MP0005376_homeostasis/metabolism_phenot0.82291260
128MP0005584_abnormal_enzyme/coenzyme_acti0.81424912
129MP0005409_darkened_coat_color0.81301279
130MP0002398_abnormal_bone_marrow0.80956744
131MP0010030_abnormal_orbit_morphology0.80938369
132MP0001835_abnormal_antigen_presentation0.80744623
133MP0010234_abnormal_vibrissa_follicle0.80635976
134MP0003303_peritoneal_inflammation0.79127425
135MP0002114_abnormal_axial_skeleton0.78945480
136MP0002019_abnormal_tumor_incidence0.78641809
137MP0001697_abnormal_embryo_size0.78155137
138MP0000685_abnormal_immune_system0.77220929
139MP0002095_abnormal_skin_pigmentation0.74724280
140MP0004782_abnormal_surfactant_physiolog0.74251293
141MP0000762_abnormal_tongue_morphology0.73365762
142MP0004147_increased_porphyrin_level0.72287747
143MP0004510_myositis0.72244727
144MP0001666_abnormal_nutrient_absorption0.71266841
145MP0001764_abnormal_homeostasis0.71192668
146MP0003866_abnormal_defecation0.71037050
147MP0000609_abnormal_liver_physiology0.70797725
148MP0008770_decreased_survivor_rate0.70049754
149MP0000716_abnormal_immune_system0.69324141
150MP0005384_cellular_phenotype0.68576776
151MP0003172_abnormal_lysosome_physiology0.68377036
152MP0004019_abnormal_vitamin_homeostasis0.67962502
153MP0001533_abnormal_skeleton_physiology0.67209021
154MP0003656_abnormal_erythrocyte_physiolo0.67204264
155MP0005391_vision/eye_phenotype0.66882968
156MP0002796_impaired_skin_barrier0.66678117
157MP0005410_abnormal_fertilization0.66404946
158MP0008872_abnormal_physiological_respon0.66354438
159MP0009764_decreased_sensitivity_to0.65809273
160MP0005397_hematopoietic_system_phenotyp0.65515081
161MP0002269_muscular_atrophy0.65309508
162MP0002084_abnormal_developmental_patter0.63646788
163MP0002233_abnormal_nose_morphology0.62183930
164MP0001800_abnormal_humoral_immune0.60475303
165MP0004133_heterotaxia0.59499366
166MP0000598_abnormal_liver_morphology0.58281563
167MP0000703_abnormal_thymus_morphology0.57049269
168MP0003221_abnormal_cardiomyocyte_apopto0.53751114
169MP0008875_abnormal_xenobiotic_pharmacok0.53585216
170MP0003137_abnormal_impulse_conducting0.52700518
171MP0000343_altered_response_to0.52265213

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.83340477
2Hypochromic microcytic anemia (HP:0004840)5.76553226
3Multiple enchondromatosis (HP:0005701)5.59425091
4Hepatoblastoma (HP:0002884)4.85611301
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.53230377
6Amelogenesis imperfecta (HP:0000705)4.51890261
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.09563596
8Ragged-red muscle fibers (HP:0003200)4.08827386
9Abnormality of the lower motor neuron (HP:0002366)4.03551721
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.94357627
11Rib fusion (HP:0000902)3.86062788
12Reduced antithrombin III activity (HP:0001976)3.84590822
13Ependymoma (HP:0002888)3.84037359
14Parakeratosis (HP:0001036)3.77771992
15Hypoplasia of the fovea (HP:0007750)3.56601989
16Aplasia/Hypoplasia of the fovea (HP:0008060)3.56601989
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.52472404
18Microvesicular hepatic steatosis (HP:0001414)3.43853799
19Nephroblastoma (Wilms tumor) (HP:0002667)3.42619820
20Partial duplication of thumb phalanx (HP:0009944)3.38730231
21Neoplasm of striated muscle (HP:0009728)3.31389645
22Rhabdomyosarcoma (HP:0002859)3.31076436
23Abnormality of glycolysis (HP:0004366)3.24850047
24Increased serum pyruvate (HP:0003542)3.24850047
253-Methylglutaconic aciduria (HP:0003535)3.24722624
26Purpura (HP:0000979)3.21575598
27Petechiae (HP:0000967)3.20913097
28Type I transferrin isoform profile (HP:0003642)3.15208113
29Embryonal renal neoplasm (HP:0011794)3.14612146
30Acanthocytosis (HP:0001927)3.14256943
31Increased cerebral lipofuscin (HP:0011813)3.06494798
32Testicular atrophy (HP:0000029)3.05841989
33Colitis (HP:0002583)3.05768115
34Abnormal lung lobation (HP:0002101)3.04911905
35Dysostosis multiplex (HP:0000943)3.04538002
36Chromsome breakage (HP:0040012)2.99982348
37Vacuolated lymphocytes (HP:0001922)2.99335309
38Bifid tongue (HP:0010297)2.99021545
39Abnormality of macrophages (HP:0004311)2.98100184
40Trismus (HP:0000211)2.97294978
41Loss of speech (HP:0002371)2.93951827
42Congenital ichthyosiform erythroderma (HP:0007431)2.91602064
43Combined immunodeficiency (HP:0005387)2.90925225
44J-shaped sella turcica (HP:0002680)2.89027188
45Rectal fistula (HP:0100590)2.88692442
46Rectovaginal fistula (HP:0000143)2.88692442
47Hyperinsulinemic hypoglycemia (HP:0000825)2.88248535
48Microretrognathia (HP:0000308)2.85799444
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.85334504
50Partial duplication of the phalanx of hand (HP:0009999)2.83469813
51Amyotrophic lateral sclerosis (HP:0007354)2.83008233
52Abnormality of the fovea (HP:0000493)2.81531389
53Abnormal cartilage morphology (HP:0002763)2.79605447
54Aplastic anemia (HP:0001915)2.79594651
55Abnormality of polysaccharide metabolism (HP:0011012)2.78389763
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.78389763
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.78389763
58Anomalous pulmonary venous return (HP:0010772)2.75508207
59Achilles tendon contracture (HP:0001771)2.71388991
60Tongue fasciculations (HP:0001308)2.70290414
61Recurrent abscess formation (HP:0002722)2.66962719
62Hyperventilation (HP:0002883)2.65781229
63Horizontal nystagmus (HP:0000666)2.64477608
64Urinary glycosaminoglycan excretion (HP:0003541)2.64316626
65Mucopolysacchariduria (HP:0008155)2.64316626
66Ulnar bowing (HP:0003031)2.62741253
67Cholecystitis (HP:0001082)2.62712996
68Abnormal gallbladder physiology (HP:0012438)2.62712996
69Abnormality of the Achilles tendon (HP:0005109)2.62459116
70Progressive muscle weakness (HP:0003323)2.62126932
71Fused cervical vertebrae (HP:0002949)2.59704665
72Intestinal fistula (HP:0100819)2.56400978
73Pendular nystagmus (HP:0012043)2.56292843
74Hypochromic anemia (HP:0001931)2.56034184
75Vaginal fistula (HP:0004320)2.54583707
76Meckel diverticulum (HP:0002245)2.53957730
77Aplasia/Hypoplasia of the sacrum (HP:0008517)2.53111800
78Vertebral compression fractures (HP:0002953)2.52751751
79Spontaneous hematomas (HP:0007420)2.51377290
80Preauricular skin tag (HP:0000384)2.46618078
81Systemic lupus erythematosus (HP:0002725)2.44336447
82Abnormality of the salivary glands (HP:0010286)2.44327611
83Recurrent bacterial skin infections (HP:0005406)2.42187009
84Nuclear cataract (HP:0100018)2.41195694
85Upper limb amyotrophy (HP:0009129)2.39254242
86Distal upper limb amyotrophy (HP:0007149)2.39254242
87Gastrointestinal inflammation (HP:0004386)2.38579537
88Hypokinesia (HP:0002375)2.37922175
89Generalized hypotonia (HP:0001290)2.37083449
90Astrocytoma (HP:0009592)2.36748250
91Abnormality of the astrocytes (HP:0100707)2.36748250
92Abnormality of the ileum (HP:0001549)2.36537401
93Gastrointestinal stroma tumor (HP:0100723)2.35889667
94Abnormality of the intrinsic pathway (HP:0010989)2.34906581
95Sensory axonal neuropathy (HP:0003390)2.33945131
96Deep venous thrombosis (HP:0002625)2.33847789
97Difficulty walking (HP:0002355)2.33626239
98Muscle fibrillation (HP:0010546)2.33224057
99Atrophy/Degeneration involving motor neurons (HP:0007373)2.30286954
100Rectal prolapse (HP:0002035)2.28606760
101Impulsivity (HP:0100710)2.28594958
102Fatigue (HP:0012378)2.28400320
103Glomerulonephritis (HP:0000099)2.28282905
104Abnormality of the pulmonary veins (HP:0011718)2.27956543
105Tetraplegia (HP:0002445)2.27631353
106Aplasia/Hypoplasia of the uvula (HP:0010293)2.26655967
107Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.24522340
108Eczematoid dermatitis (HP:0000976)2.24338216
109Nasolacrimal duct obstruction (HP:0000579)2.24260499
110Aplasia/Hypoplasia of the macula (HP:0008059)2.23738010
111Nasal polyposis (HP:0100582)2.22649486
112Opisthotonus (HP:0002179)2.20143703
113Abnormality of glycolipid metabolism (HP:0010969)2.19281471
114Abnormality of liposaccharide metabolism (HP:0010968)2.19281471
115Abnormality of glycosphingolipid metabolism (HP:0004343)2.19281471
116Upper motor neuron abnormality (HP:0002127)2.19270286
117Thoracic kyphosis (HP:0002942)2.19164568
118Elevated erythrocyte sedimentation rate (HP:0003565)2.18808672
119Premature ovarian failure (HP:0008209)2.17213174
120Inflammation of the large intestine (HP:0002037)2.16958665
121Hypertensive crisis (HP:0100735)2.15061430
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14778206
123Glossoptosis (HP:0000162)2.13112965
124Axonal loss (HP:0003447)2.11783896
125Skin tags (HP:0010609)2.08384860
126Aplasia/hypoplasia of the humerus (HP:0006507)2.07361225
127Villous atrophy (HP:0011473)2.06373392
128Abnormality of small intestinal villus morphology (HP:0011472)2.06373392
129Abnormality of the vocal cords (HP:0008777)2.05337088
130Increased serum ferritin (HP:0003281)2.04392307
131Amyloidosis (HP:0011034)2.04320314
132Progressive external ophthalmoplegia (HP:0000590)2.03969833
133Obstructive lung disease (HP:0006536)2.03482019
134Chronic obstructive pulmonary disease (HP:0006510)2.03482019
135Severe visual impairment (HP:0001141)2.02427124
136Hand muscle atrophy (HP:0009130)2.02266737
137Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01667339
138Duodenal stenosis (HP:0100867)2.00558642
139Small intestinal stenosis (HP:0012848)2.00558642
140Hemorrhage of the eye (HP:0011885)2.00022720
141Aplasia/Hypoplasia affecting the retina (HP:0008061)2.00010092
142Short 5th finger (HP:0009237)1.99770473
143Peripheral hypomyelination (HP:0007182)1.99151952
144Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98247274
145Abnormal protein N-linked glycosylation (HP:0012347)1.98247274
146Abnormal protein glycosylation (HP:0012346)1.98247274
147Abnormal glycosylation (HP:0012345)1.98247274
148Myelodysplasia (HP:0002863)1.97784055
149Scapular winging (HP:0003691)1.95887292
150Fasciculations (HP:0002380)1.95007545
151Subcapsular cataract (HP:0000523)1.94783301
152Periauricular skin pits (HP:0100277)1.94279336
153Preauricular pit (HP:0004467)1.94279336
154Cheilitis (HP:0100825)1.94213102
155Abnormality of pyrimidine metabolism (HP:0004353)1.92372107
156Supernumerary spleens (HP:0009799)1.92028959
157Abnormality of the heme biosynthetic pathway (HP:0010472)1.91781479
158Facial cleft (HP:0002006)1.91512043
159Progressive neurologic deterioration (HP:0002344)1.90868874
160Shawl scrotum (HP:0000049)1.89471213
161Abnormality of the nasal mucosa (HP:0000433)1.88911361
162Abnormality of the phalanges of the hallux (HP:0010057)1.88810400
163Stridor (HP:0010307)1.88794240
164Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88056627
165Abnormality of the thoracic spine (HP:0100711)1.88052931
166Xanthomatosis (HP:0000991)1.86866990
167Short humerus (HP:0005792)1.86131639
168Nausea (HP:0002018)1.86084964
169Hypophosphatemia (HP:0002148)1.85543292
170Recurrent gram-negative bacterial infections (HP:0005420)1.85322258
171Bilateral sensorineural hearing impairment (HP:0008619)1.85130910
172Centrally nucleated skeletal muscle fibers (HP:0003687)1.84777976
173Stroke (HP:0001297)1.84416379
174Esophageal varix (HP:0002040)1.82185770
175Cellulitis (HP:0100658)1.82046364
176Thin bony cortex (HP:0002753)1.81846530
177Distal lower limb amyotrophy (HP:0008944)1.81798459
178Deformed sella turcica (HP:0002681)1.80436540
179Overlapping toe (HP:0001845)1.79518690
180Focal motor seizures (HP:0011153)1.79070721
181Hematochezia (HP:0002573)1.77166952
182Ulnar claw (HP:0001178)1.76911157
183Asymmetric septal hypertrophy (HP:0001670)1.76057524
184Distal lower limb muscle weakness (HP:0009053)1.75247258
185Segmental peripheral demyelination/remyelination (HP:0003481)1.74294575
186Radial bowing (HP:0002986)1.73457819
187Pustule (HP:0200039)1.72015171
188Malnutrition (HP:0004395)1.71642764
189Myopathic facies (HP:0002058)1.70380914
190Diaphragmatic weakness (HP:0009113)1.69929356

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.00692504
2LATS16.66968755
3ERN15.10566826
4GRK54.95498428
5GRK64.37132685
6LATS24.29999796
7ADRBK23.65533408
8STK38L3.49511849
9CSF1R3.45410404
10GRK12.98668833
11IRAK32.84389577
12TRIB32.76072131
13TGFBR22.68977658
14GRK72.63135983
15MATK2.44945276
16TTK2.31262775
17STK382.23962216
18MAPK72.14456882
19PRKD32.14319295
20MST1R2.10974967
21STK102.05811290
22PRPF4B1.86718418
23TESK11.80833804
24MAP2K21.80049051
25SIK11.76037729
26MOS1.68404739
27SMG11.67751981
28PDPK11.65546038
29MAP3K111.65410158
30TYRO31.64051249
31ARAF1.62605079
32CDK71.61948934
33RIPK41.59029792
34WNK11.56529461
35PRKG21.49007991
36KSR21.48253236
37MAP3K21.45692442
38PAK41.40376878
39CAMK41.27052397
40BUB11.23752552
41TNK21.19011585
42CHEK21.17842948
43MAP2K61.16827809
44MAP3K31.16022389
45PLK11.14763503
46ICK1.14085385
47NTRK11.13859230
48MAP3K101.12529490
49ADRBK11.11915977
50RIPK11.08909152
51MAP4K11.06861517
52MARK21.05997018
53HIPK21.02887248
54WEE11.01287967
55MELK1.00330128
56TBK10.99690611
57MAP3K10.97988510
58EPHA20.97660864
59MAP2K40.96766321
60CCNB10.95701858
61MAP3K130.94692993
62ACVR1B0.92233637
63STK160.88290836
64PDK20.87548754
65ABL20.85876019
66TESK20.85465421
67CDC70.85227997
68SRPK10.84615690
69IRAK40.83604595
70KIT0.83298173
71NEK20.83222397
72DYRK30.82559871
73BLK0.81235520
74AKT30.79469059
75EIF2AK30.78641930
76EIF2AK20.78334848
77BCKDK0.78117530
78MAP3K80.76833296
79PRKD20.74508713
80TAOK10.72201230
81EIF2AK10.70580371
82SIK30.68708723
83CHEK10.67480494
84FLT30.67253661
85CDK80.66040952
86PRKD10.65821236
87NME20.65320365
88ZAP700.65114077
89AKT20.62135798
90BRAF0.60829613
91PDK40.60154224
92PDK30.60154224
93MAPK110.58209065
94FGFR30.57319492
95MAPK120.56521319
96EPHB10.56156117
97MET0.55851015
98VRK10.53182207
99AURKA0.52285520
100CSK0.51551251
101PDK10.51078605
102EEF2K0.51058974
103ITK0.50668220
104AURKB0.49985548
105PRKAA20.48900532
106BMX0.48557839
107BRSK20.47089370
108NLK0.46705948
109IRAK20.46642332
110PTK60.46514497
111LMTK20.46272821
112LRRK20.46142493
113IGF1R0.44423694
114MAPK40.44385972
115CDK40.43967437
116PRKCD0.42926186
117SIK20.42299733
118WNK30.41209486
119IKBKB0.40734165
120CDK20.40303215
121PRKCI0.40124067
122CDK190.39928659
123STK30.39447034
124RPS6KB20.38773786
125SCYL20.37711099
126NEK10.37629139
127TSSK60.37319141
128JAK30.36515868
129PIM20.36353222
130LIMK10.35924960
131DYRK20.35440505
132MAPKAPK30.35345188
133IKBKE0.34525628
134PAK10.34269438
135KDR0.34266906
136SYK0.33779032
137CSNK1A1L0.33456521
138MAP3K70.33427087
139DAPK10.32062140
140CDC42BPA0.31981850
141BRSK10.31903538
142ATR0.31573956
143MAP2K30.30196711
144RPS6KA20.29489730
145NME10.29456845
146ATM0.27429538
147PTK20.26376749
148VRK20.26246074
149NEK90.25299727
150TAOK20.23269517
151MST40.21609628
152LCK0.21101684
153CDK10.20909019
154ALK0.20033655
155LYN0.16881617
156MTOR0.16289628
157CSNK2A10.16053880
158TLK10.16024733
159TYK20.14826831
160CSNK2A20.12027000
161MAPKAPK20.11965677
162PRKACB0.11825619

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.88106857
2Vitamin B6 metabolism_Homo sapiens_hsa007505.22774300
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.36267852
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.92656185
5Sphingolipid metabolism_Homo sapiens_hsa006003.66979033
6Ribosome_Homo sapiens_hsa030103.25926054
7Fructose and mannose metabolism_Homo sapiens_hsa000513.24790213
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.88775183
9DNA replication_Homo sapiens_hsa030302.87746304
10Galactose metabolism_Homo sapiens_hsa000522.52160672
11Mismatch repair_Homo sapiens_hsa034302.37006628
12Proteasome_Homo sapiens_hsa030502.26229537
13Arachidonic acid metabolism_Homo sapiens_hsa005902.19233904
14Phenylalanine metabolism_Homo sapiens_hsa003602.16611127
15Lysosome_Homo sapiens_hsa041422.13900383
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.09858825
17Homologous recombination_Homo sapiens_hsa034401.98053294
18RNA transport_Homo sapiens_hsa030131.95413609
19RNA polymerase_Homo sapiens_hsa030201.86035455
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.82692747
21Base excision repair_Homo sapiens_hsa034101.79524462
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.79253370
23Spliceosome_Homo sapiens_hsa030401.72849515
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69732234
25Other glycan degradation_Homo sapiens_hsa005111.69119362
26Linoleic acid metabolism_Homo sapiens_hsa005911.61973944
27VEGF signaling pathway_Homo sapiens_hsa043701.59904862
28Fanconi anemia pathway_Homo sapiens_hsa034601.55473866
29Folate biosynthesis_Homo sapiens_hsa007901.54626606
30Pyrimidine metabolism_Homo sapiens_hsa002401.53323262
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45318521
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44283507
33Pentose phosphate pathway_Homo sapiens_hsa000301.41124794
34Sulfur relay system_Homo sapiens_hsa041221.40147421
35Sphingolipid signaling pathway_Homo sapiens_hsa040711.39614828
36Cell cycle_Homo sapiens_hsa041101.34216041
37RNA degradation_Homo sapiens_hsa030181.30884352
38Collecting duct acid secretion_Homo sapiens_hsa049661.30339498
39One carbon pool by folate_Homo sapiens_hsa006701.30204323
40Non-homologous end-joining_Homo sapiens_hsa034501.26294535
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21191334
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20951347
43Osteoclast differentiation_Homo sapiens_hsa043801.18952630
44Primary immunodeficiency_Homo sapiens_hsa053401.15791012
45Tuberculosis_Homo sapiens_hsa051521.13711765
46Vibrio cholerae infection_Homo sapiens_hsa051101.11543292
47Basal transcription factors_Homo sapiens_hsa030221.10393734
48Chemical carcinogenesis_Homo sapiens_hsa052041.10210027
49Nucleotide excision repair_Homo sapiens_hsa034201.09848841
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08378296
51Thyroid cancer_Homo sapiens_hsa052161.07975930
52Carbon metabolism_Homo sapiens_hsa012001.04689993
53Drug metabolism - other enzymes_Homo sapiens_hsa009831.03382298
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03372951
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00483214
56B cell receptor signaling pathway_Homo sapiens_hsa046620.99293891
57Vitamin digestion and absorption_Homo sapiens_hsa049770.96505088
58mRNA surveillance pathway_Homo sapiens_hsa030150.95273487
59Oxidative phosphorylation_Homo sapiens_hsa001900.94873672
60Pancreatic cancer_Homo sapiens_hsa052120.93944138
61Parkinsons disease_Homo sapiens_hsa050120.93532535
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93322977
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92645030
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.87538775
65Tyrosine metabolism_Homo sapiens_hsa003500.86835894
66Protein export_Homo sapiens_hsa030600.84839244
67Biosynthesis of amino acids_Homo sapiens_hsa012300.82093710
68Sulfur metabolism_Homo sapiens_hsa009200.82084126
69Bladder cancer_Homo sapiens_hsa052190.79698776
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78721117
71Chronic myeloid leukemia_Homo sapiens_hsa052200.78022764
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.73721220
73Prion diseases_Homo sapiens_hsa050200.73306780
74Metabolic pathways_Homo sapiens_hsa011000.71278492
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71113168
76Endocytosis_Homo sapiens_hsa041440.70295486
77Histidine metabolism_Homo sapiens_hsa003400.68573012
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67935605
79Arginine biosynthesis_Homo sapiens_hsa002200.67083784
80Herpes simplex infection_Homo sapiens_hsa051680.66814929
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65797231
82Tryptophan metabolism_Homo sapiens_hsa003800.65254814
83Synaptic vesicle cycle_Homo sapiens_hsa047210.65169828
84Huntingtons disease_Homo sapiens_hsa050160.65004975
85Ether lipid metabolism_Homo sapiens_hsa005650.64227123
86Dorso-ventral axis formation_Homo sapiens_hsa043200.63971613
87Selenocompound metabolism_Homo sapiens_hsa004500.63601340
88Staphylococcus aureus infection_Homo sapiens_hsa051500.63535663
89Leishmaniasis_Homo sapiens_hsa051400.62478774
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61682410
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61422276
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61021826
93Hepatitis C_Homo sapiens_hsa051600.60624456
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59313096
95Starch and sucrose metabolism_Homo sapiens_hsa005000.58538235
96Viral myocarditis_Homo sapiens_hsa054160.58012645
97Purine metabolism_Homo sapiens_hsa002300.57236247
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54827300
99Renal cell carcinoma_Homo sapiens_hsa052110.54066492
100Glutathione metabolism_Homo sapiens_hsa004800.52382687
101Non-small cell lung cancer_Homo sapiens_hsa052230.51548634
102Regulation of autophagy_Homo sapiens_hsa041400.51452418
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51410191
104p53 signaling pathway_Homo sapiens_hsa041150.51329913
105Toxoplasmosis_Homo sapiens_hsa051450.50558866
106Pertussis_Homo sapiens_hsa051330.49342934
107Shigellosis_Homo sapiens_hsa051310.49098468
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.48533510
109Fatty acid elongation_Homo sapiens_hsa000620.46873535
110Hepatitis B_Homo sapiens_hsa051610.46684769
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44952189
112Bile secretion_Homo sapiens_hsa049760.44823313
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43683642
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43402241
115Pyruvate metabolism_Homo sapiens_hsa006200.42844347
116GnRH signaling pathway_Homo sapiens_hsa049120.42783828
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41542014
118mTOR signaling pathway_Homo sapiens_hsa041500.40936413
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40292811
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40026758
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39913252
122Salmonella infection_Homo sapiens_hsa051320.39340275
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38900300
124Influenza A_Homo sapiens_hsa051640.38766470
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.37920517
126PPAR signaling pathway_Homo sapiens_hsa033200.37414318
127Caffeine metabolism_Homo sapiens_hsa002320.36932896
128TNF signaling pathway_Homo sapiens_hsa046680.35570341
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35371816
130Acute myeloid leukemia_Homo sapiens_hsa052210.33343860
131Alzheimers disease_Homo sapiens_hsa050100.32959915
132Phagosome_Homo sapiens_hsa041450.32804460
133Fatty acid degradation_Homo sapiens_hsa000710.31114794
134Endometrial cancer_Homo sapiens_hsa052130.30943176
135Arginine and proline metabolism_Homo sapiens_hsa003300.30879197
136Peroxisome_Homo sapiens_hsa041460.30825289
137Epstein-Barr virus infection_Homo sapiens_hsa051690.30562319
138Retinol metabolism_Homo sapiens_hsa008300.30464019
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30050415
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.29789803
141Insulin signaling pathway_Homo sapiens_hsa049100.29542184
142Insulin resistance_Homo sapiens_hsa049310.28797560
143Glycerolipid metabolism_Homo sapiens_hsa005610.28473870
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.27952424
145Renin-angiotensin system_Homo sapiens_hsa046140.27206606
146N-Glycan biosynthesis_Homo sapiens_hsa005100.25080104
147Ovarian steroidogenesis_Homo sapiens_hsa049130.23607134
148Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23145386
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22508827
150Cyanoamino acid metabolism_Homo sapiens_hsa004600.22477601
151Intestinal immune network for IgA production_Homo sapiens_hsa046720.20110881
152Legionellosis_Homo sapiens_hsa051340.19381209
153Central carbon metabolism in cancer_Homo sapiens_hsa052300.19287546
154Complement and coagulation cascades_Homo sapiens_hsa046100.18739728
155Maturity onset diabetes of the young_Homo sapiens_hsa049500.18727571
156Antigen processing and presentation_Homo sapiens_hsa046120.17204460
157Apoptosis_Homo sapiens_hsa042100.15481832
158Inositol phosphate metabolism_Homo sapiens_hsa005620.14893294
159Viral carcinogenesis_Homo sapiens_hsa052030.13840655
160Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13657720
161Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.13319156
162Hematopoietic cell lineage_Homo sapiens_hsa046400.09659181

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