ZFYVE21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.02898955
2L-phenylalanine catabolic process (GO:0006559)5.02898955
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.92996395
4L-phenylalanine metabolic process (GO:0006558)4.92996395
5cysteine metabolic process (GO:0006534)4.27759054
6sulfur amino acid catabolic process (GO:0000098)4.19676491
7fatty acid elongation (GO:0030497)4.14240592
8glyoxylate metabolic process (GO:0046487)4.02120544
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.98627671
10alpha-linolenic acid metabolic process (GO:0036109)3.96480232
11serine family amino acid biosynthetic process (GO:0009070)3.95475969
12aromatic amino acid family catabolic process (GO:0009074)3.92205156
13protein neddylation (GO:0045116)3.74608238
14L-serine metabolic process (GO:0006563)3.59858342
15lysine catabolic process (GO:0006554)3.58592552
16lysine metabolic process (GO:0006553)3.58592552
17ethanol oxidation (GO:0006069)3.57584872
18retinal cone cell development (GO:0046549)3.53163222
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.50213322
20branched-chain amino acid catabolic process (GO:0009083)3.43233798
21response to nitrosative stress (GO:0051409)3.41914985
22bile acid biosynthetic process (GO:0006699)3.41429130
23serine family amino acid metabolic process (GO:0009069)3.38591943
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36314673
25glycine metabolic process (GO:0006544)3.35587262
26fatty acid beta-oxidation (GO:0006635)3.32301782
27amino-acid betaine metabolic process (GO:0006577)3.28215827
28aspartate family amino acid catabolic process (GO:0009068)3.28212907
29proline metabolic process (GO:0006560)3.25763958
30Golgi transport vesicle coating (GO:0048200)3.25441162
31COPI coating of Golgi vesicle (GO:0048205)3.25441162
32proline biosynthetic process (GO:0006561)3.24801926
33response to misfolded protein (GO:0051788)3.23547533
34regulation of cholesterol esterification (GO:0010872)3.23452042
35reverse cholesterol transport (GO:0043691)3.22271252
36serine family amino acid catabolic process (GO:0009071)3.20309525
37high-density lipoprotein particle remodeling (GO:0034375)3.19730509
38neuronal action potential propagation (GO:0019227)3.18913000
39negative regulation of appetite (GO:0032099)3.16400315
40negative regulation of response to food (GO:0032096)3.16400315
41neurotransmitter catabolic process (GO:0042135)3.13663736
42tryptophan catabolic process (GO:0006569)3.09797235
43indole-containing compound catabolic process (GO:0042436)3.09797235
44indolalkylamine catabolic process (GO:0046218)3.09797235
45cellular ketone body metabolic process (GO:0046950)3.09739012
46fatty acid oxidation (GO:0019395)3.08946482
47lipid oxidation (GO:0034440)3.07498320
48tryptophan metabolic process (GO:0006568)3.06319523
49regulation of integrin-mediated signaling pathway (GO:2001044)3.06153284
50kynurenine metabolic process (GO:0070189)3.06070904
51alpha-amino acid catabolic process (GO:1901606)3.05343965
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04909171
53homocysteine metabolic process (GO:0050667)3.04419761
54L-methionine salvage (GO:0071267)3.02305905
55L-methionine biosynthetic process (GO:0071265)3.02305905
56amino acid salvage (GO:0043102)3.02305905
57valine metabolic process (GO:0006573)3.02113721
58branched-chain amino acid metabolic process (GO:0009081)3.00426663
59fat-soluble vitamin biosynthetic process (GO:0042362)2.99699156
60cellular amino acid catabolic process (GO:0009063)2.99378147
61short-chain fatty acid metabolic process (GO:0046459)2.99149585
62mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.99132601
63fatty acid catabolic process (GO:0009062)2.98170299
64response to gravity (GO:0009629)2.97903285
65aldehyde catabolic process (GO:0046185)2.96941520
66regulation of cholesterol biosynthetic process (GO:0045540)2.96892597
67cellular modified amino acid catabolic process (GO:0042219)2.96338546
68L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.92737150
69negative regulation of heart rate (GO:0010459)2.91382231
70regulation of cholesterol metabolic process (GO:0090181)2.91241976
71aromatic amino acid family metabolic process (GO:0009072)2.90660770
72protein complex biogenesis (GO:0070271)2.89692161
73postsynaptic membrane organization (GO:0001941)2.88150615
74pteridine-containing compound biosynthetic process (GO:0042559)2.86045293
75bile acid metabolic process (GO:0008206)2.85446291
76triglyceride homeostasis (GO:0070328)2.84988665
77acylglycerol homeostasis (GO:0055090)2.84988665
78organic acid catabolic process (GO:0016054)2.82125251
79carboxylic acid catabolic process (GO:0046395)2.82125251
80nitrogen cycle metabolic process (GO:0071941)2.81438148
81monocarboxylic acid catabolic process (GO:0072329)2.80957397
82coenzyme catabolic process (GO:0009109)2.80938581
83quinone biosynthetic process (GO:1901663)2.80692036
84ubiquinone biosynthetic process (GO:0006744)2.80692036
854-hydroxyproline metabolic process (GO:0019471)2.80681423
86urea metabolic process (GO:0019627)2.80238029
87urea cycle (GO:0000050)2.80238029
88carnitine metabolic process (GO:0009437)2.80219483
89cullin deneddylation (GO:0010388)2.79983453
90neurotransmitter uptake (GO:0001504)2.79392605
91negative regulation of fibrinolysis (GO:0051918)2.78213762
92peptidyl-glutamic acid carboxylation (GO:0017187)2.77944234
93protein carboxylation (GO:0018214)2.77944234
94negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.77178873
95regulation of protein activation cascade (GO:2000257)2.75320337
96protein deneddylation (GO:0000338)2.75280107
97aspartate family amino acid metabolic process (GO:0009066)2.74884350
98negative regulation of protein localization to cell surface (GO:2000009)2.74201544
99plasma lipoprotein particle remodeling (GO:0034369)2.73961753
100protein-lipid complex remodeling (GO:0034368)2.73961753
101macromolecular complex remodeling (GO:0034367)2.73961753
102regulation of triglyceride catabolic process (GO:0010896)2.73950453
103regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.73216331
104sulfur amino acid biosynthetic process (GO:0000097)2.71949603
105acetyl-CoA metabolic process (GO:0006084)2.71490369
106vocalization behavior (GO:0071625)2.70019690
107sulfur amino acid metabolic process (GO:0000096)2.67854758
108alpha-amino acid biosynthetic process (GO:1901607)2.67370058
109behavioral response to nicotine (GO:0035095)2.67341453
110biotin metabolic process (GO:0006768)2.67183241
111drug metabolic process (GO:0017144)2.66183459
112protein retention in ER lumen (GO:0006621)2.65771286
1132-oxoglutarate metabolic process (GO:0006103)2.64537299
114maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.64173305
115ketone body metabolic process (GO:1902224)2.64096337
116very long-chain fatty acid metabolic process (GO:0000038)2.63118361
117peptidyl-histidine modification (GO:0018202)2.62167713
118peroxisome fission (GO:0016559)2.61815438
119regulation of complement activation (GO:0030449)2.61354058
120glutamine family amino acid biosynthetic process (GO:0009084)2.60342216
121tyrosine metabolic process (GO:0006570)2.60130751
122folic acid metabolic process (GO:0046655)2.59961541
123regulation of fibrinolysis (GO:0051917)2.59624353
124xenobiotic catabolic process (GO:0042178)2.59484368
125platelet dense granule organization (GO:0060155)2.59257279
126RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.56851972
127tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.56851972
128mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.53685214
129mitochondrial respiratory chain complex I assembly (GO:0032981)2.53685214
130NADH dehydrogenase complex assembly (GO:0010257)2.53685214
131glutathione derivative metabolic process (GO:1901685)2.51620737
132glutathione derivative biosynthetic process (GO:1901687)2.51620737
133positive regulation of meiosis (GO:0045836)2.50491969
134mitochondrial respiratory chain complex assembly (GO:0033108)2.50316016
135C4-dicarboxylate transport (GO:0015740)2.46215943
136piRNA metabolic process (GO:0034587)2.44011607
137proteasome assembly (GO:0043248)2.43041124
138water-soluble vitamin biosynthetic process (GO:0042364)2.42607902
139regulation of response to food (GO:0032095)2.42048684
140axoneme assembly (GO:0035082)2.41786404
141negative regulation of cation channel activity (GO:2001258)2.40875981
142phenol-containing compound catabolic process (GO:0019336)2.39200604
143electron transport chain (GO:0022900)2.39199678
144negative regulation of calcium ion transmembrane transport (GO:1903170)2.37426320
145negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.37426320
146synaptic vesicle maturation (GO:0016188)2.34145797
147positive regulation of meiotic cell cycle (GO:0051446)2.33531452
148lipopolysaccharide biosynthetic process (GO:0009103)2.33499408
149regulation of neurotransmitter uptake (GO:0051580)2.33255216
150mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.32104609
151respiratory electron transport chain (GO:0022904)2.31825786
152ovulation cycle (GO:0042698)2.30853132
153synaptic vesicle docking involved in exocytosis (GO:0016081)2.30304430
154mannosylation (GO:0097502)2.29376449
155regulation of sensory perception (GO:0051931)2.28413933
156regulation of sensory perception of pain (GO:0051930)2.28413933
157nonmotile primary cilium assembly (GO:0035058)2.25499527
158auditory behavior (GO:0031223)2.25129075
159chaperone-mediated protein transport (GO:0072321)2.23593933
160respiratory chain complex IV assembly (GO:0008535)2.23430088
161axon ensheathment in central nervous system (GO:0032291)2.23070506
162central nervous system myelination (GO:0022010)2.23070506
163transmission of nerve impulse (GO:0019226)2.20428038
164calcium-mediated signaling using intracellular calcium source (GO:0035584)2.20253691
165neuron cell-cell adhesion (GO:0007158)2.19103941
166positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.18616782
167tonic smooth muscle contraction (GO:0014820)2.17307396
168regulation of dopamine metabolic process (GO:0042053)2.16737006
169regulation of catecholamine metabolic process (GO:0042069)2.16737006
170neuromuscular process controlling posture (GO:0050884)2.16521913
171regulation of cell proliferation involved in kidney development (GO:1901722)2.16482456
172regulation of voltage-gated calcium channel activity (GO:1901385)2.16218717
173presynaptic membrane assembly (GO:0097105)2.14816939
174cellular response to leptin stimulus (GO:0044320)2.14721459
175hydrogen ion transmembrane transport (GO:1902600)2.14371184
176regulation of cilium movement (GO:0003352)2.12787849
177energy coupled proton transport, down electrochemical gradient (GO:0015985)2.12714532
178ATP synthesis coupled proton transport (GO:0015986)2.12714532
179response to redox state (GO:0051775)2.11341199
180regulation of short-term neuronal synaptic plasticity (GO:0048172)2.10806418
181cornea development in camera-type eye (GO:0061303)2.10018910
182regulation of microtubule-based movement (GO:0060632)2.09868820
183neurotransmitter metabolic process (GO:0042133)2.09442643
184neuronal action potential (GO:0019228)2.09415036
185cytochrome complex assembly (GO:0017004)2.08991588
186mesonephros development (GO:0001823)2.08819208
187regulation of appetite (GO:0032098)2.07900189
188regulation of mesoderm development (GO:2000380)2.06628842

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.45890514
2EZH2_22144423_ChIP-Seq_EOC_Human4.73322216
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.57397721
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.00374660
5* PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.88392316
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.62236660
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.29189463
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.15226528
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09683769
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.07352439
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72349667
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66552549
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.58398627
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49673894
15GBX2_23144817_ChIP-Seq_PC3_Human2.45883060
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.32658865
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28611531
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27333849
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25928535
20VDR_22108803_ChIP-Seq_LS180_Human2.25363524
21ZNF274_21170338_ChIP-Seq_K562_Hela2.22303900
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.20288979
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20067784
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.19447816
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.15415582
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12626060
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09706163
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06428660
29AR_21909140_ChIP-Seq_LNCAP_Human2.03045441
30MYC_18555785_ChIP-Seq_MESCs_Mouse2.00312083
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97838318
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.81532728
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79154030
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77221743
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.74174546
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.67302115
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65603654
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64073008
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60720708
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.60705171
41REST_21632747_ChIP-Seq_MESCs_Mouse1.60453342
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.55509897
43GABP_19822575_ChIP-Seq_HepG2_Human1.55381194
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55264702
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50269136
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49638547
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49093912
48CLOCK_20551151_ChIP-Seq_293T_Human1.47813734
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47298702
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45961078
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.45782969
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45195953
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43101353
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42229736
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.41751394
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40520469
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.40376426
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38068399
59KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36945798
60DCP1A_22483619_ChIP-Seq_HELA_Human1.35430894
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34308727
62* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33783988
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.32953831
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31901828
65TP53_22573176_ChIP-Seq_HFKS_Human1.30809453
66BCAT_22108803_ChIP-Seq_LS180_Human1.29816684
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.28739988
68ESR1_20079471_ChIP-ChIP_T-47D_Human1.27587365
69* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.27049025
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26113323
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.25390295
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25022718
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23504512
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21075754
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20806060
76* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20518654
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20390419
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19808964
79SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19577573
80DROSHA_22980978_ChIP-Seq_HELA_Human1.19426640
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19272473
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19117122
83HOXB7_26014856_ChIP-Seq_BT474_Human1.16450804
84P300_19829295_ChIP-Seq_ESCs_Human1.15900263
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15730399
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15266164
87XRN2_22483619_ChIP-Seq_HELA_Human1.13717750
88SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13535517
89* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13143953
90RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12945959
91HTT_18923047_ChIP-ChIP_STHdh_Human1.12776129
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12307247
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.11445924
94MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08531155
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.07840911
96TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05955689
97FOXA1_25329375_ChIP-Seq_VCAP_Human1.05157992
98FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05157992
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05011002
100SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04910252
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04692237
102EZH2_27304074_Chip-Seq_ESCs_Mouse1.04312984
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04137722
104VDR_23849224_ChIP-Seq_CD4+_Human1.03875110
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03846569
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03818353
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03620970
108TAF15_26573619_Chip-Seq_HEK293_Human1.02857846
109IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02521218
110NANOG_19829295_ChIP-Seq_ESCs_Human1.02311423
111SOX2_19829295_ChIP-Seq_ESCs_Human1.02311423
112RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01618418
113ER_23166858_ChIP-Seq_MCF-7_Human1.01041132
114EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00939566
115RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00939566
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00650846
117ERA_21632823_ChIP-Seq_H3396_Human1.00181238
118JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00042389
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98435084
120AR_25329375_ChIP-Seq_VCAP_Human0.98320112
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97984833
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97905373
123RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97718640
124GATA3_21878914_ChIP-Seq_MCF-7_Human0.96994436
125MYC_19829295_ChIP-Seq_ESCs_Human0.95131410
126LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94805825
127GATA4_25053715_ChIP-Seq_YYC3_Human0.94765933
128FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94753557
129ELK1_22589737_ChIP-Seq_MCF10A_Human0.94203103
130SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94200118
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94047548
132* SMAD4_21741376_ChIP-Seq_EPCs_Human0.93998750
133FOXP3_21729870_ChIP-Seq_TREG_Human0.93708888
134MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93330573
135SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92913088
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91953243
137MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91818648
138ERG_21242973_ChIP-ChIP_JURKAT_Human0.91369396
139MYC_18940864_ChIP-ChIP_HL60_Human0.90949857
140TAF2_19829295_ChIP-Seq_ESCs_Human0.90884625
141ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90680425
142HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90202359
143TCF4_22108803_ChIP-Seq_LS180_Human0.89892502
144TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89821386
145ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88885204
146RNF2_27304074_Chip-Seq_ESCs_Mouse0.88874789
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88279126
148SMAD4_21799915_ChIP-Seq_A2780_Human0.88164734
149CTCF_20526341_ChIP-Seq_ESCs_Human0.87783675
150THAP11_20581084_ChIP-Seq_MESCs_Mouse0.87610817
151POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87477031
152TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87459007
153FOXH1_21741376_ChIP-Seq_ESCs_Human0.87319736
154JARID2_20064375_ChIP-Seq_MESCs_Mouse0.86874291
155PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86818314
156PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86165636
157SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85598035
158HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85478419
159GATA4_21415370_ChIP-Seq_HL-1_Mouse0.84925428
160CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84542908
161MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.83829582
162ERG_20517297_ChIP-Seq_VCAP_Human0.83784071
163KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83246980
164CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82466350
165PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82148030
166BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82139634
167MYC_19079543_ChIP-ChIP_MESCs_Mouse0.81543048
168OCT4_20526341_ChIP-Seq_ESCs_Human0.80803012
169SMAD4_21741376_ChIP-Seq_HESCs_Human0.80794871
170SOX2_21211035_ChIP-Seq_LN229_Human0.80458949
171RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.80228027
172* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.79737747
173SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79695576
174GATA1_22025678_ChIP-Seq_K562_Human0.78211878
175ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.75572954
176YY1_22570637_ChIP-Seq_MALME-3M_Human0.74847519
177MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.74759545
178E2F7_22180533_ChIP-Seq_HELA_Human0.74541586
179SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74331155
180AR_20517297_ChIP-Seq_VCAP_Human0.73898004
181SOX17_20123909_ChIP-Seq_XEN_Mouse0.73700854
182FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73194648
183OCT4_18692474_ChIP-Seq_MEFs_Mouse0.73029042
184NANOG_21062744_ChIP-ChIP_HESCs_Human0.72869948
185* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.72860761
186NANOG_20526341_ChIP-Seq_ESCs_Human0.72750449
187ELF1_17652178_ChIP-ChIP_JURKAT_Human0.72481781

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.58600419
2MP0005360_urolithiasis4.85832066
3MP0003806_abnormal_nucleotide_metabolis4.77144738
4MP0005365_abnormal_bile_salt4.01046115
5MP0005085_abnormal_gallbladder_physiolo3.62441175
6MP0009840_abnormal_foam_cell3.52635905
7MP0002736_abnormal_nociception_after3.18367776
8MP0008875_abnormal_xenobiotic_pharmacok3.03320233
9MP0004147_increased_porphyrin_level2.92127855
10MP0003195_calcinosis2.84707664
11MP0003880_abnormal_central_pattern2.80542798
12MP0001968_abnormal_touch/_nociception2.79999864
13MP0003186_abnormal_redox_activity2.61729956
14MP0005332_abnormal_amino_acid2.52234423
15MP0003718_maternal_effect2.46062962
16MP0009780_abnormal_chondrocyte_physiolo2.44251617
17MP0008877_abnormal_DNA_methylation2.33929724
18MP0005451_abnormal_body_composition2.26197676
19MP0005423_abnormal_somatic_nervous2.24171434
20MP0001666_abnormal_nutrient_absorption2.06462710
21MP0010329_abnormal_lipoprotein_level2.06014025
22MP0002272_abnormal_nervous_system2.03957829
23MP0004859_abnormal_synaptic_plasticity2.00891206
24MP0005551_abnormal_eye_electrophysiolog1.98332616
25MP0009745_abnormal_behavioral_response1.96674640
26MP0002638_abnormal_pupillary_reflex1.96273827
27MP0001984_abnormal_olfaction1.94483060
28MP0005083_abnormal_biliary_tract1.93889777
29MP0003646_muscle_fatigue1.93715320
30MP0001486_abnormal_startle_reflex1.82225276
31MP0002734_abnormal_mechanical_nocicepti1.81798352
32MP0002064_seizures1.78690940
33MP0009046_muscle_twitch1.75079854
34MP0000579_abnormal_nail_morphology1.72335344
35MP0003252_abnormal_bile_duct1.69864101
36MP0006276_abnormal_autonomic_nervous1.69266503
37MP0006036_abnormal_mitochondrial_physio1.65641710
38MP0003136_yellow_coat_color1.65491979
39MP0009643_abnormal_urine_homeostasis1.60768381
40MP0002572_abnormal_emotion/affect_behav1.59662862
41MP0004885_abnormal_endolymph1.59587954
42MP0004215_abnormal_myocardial_fiber1.59076397
43MP0001970_abnormal_pain_threshold1.55841105
44MP0010368_abnormal_lymphatic_system1.54620150
45MP0004270_analgesia1.54192574
46MP0004133_heterotaxia1.51610212
47MP0003635_abnormal_synaptic_transmissio1.50701119
48MP0005220_abnormal_exocrine_pancreas1.50058416
49MP0003693_abnormal_embryo_hatching1.50055810
50MP0004019_abnormal_vitamin_homeostasis1.48206073
51MP0002118_abnormal_lipid_homeostasis1.46510689
52MP0002234_abnormal_pharynx_morphology1.45874393
53MP0005670_abnormal_white_adipose1.44310071
54MP0004043_abnormal_pH_regulation1.43599457
55MP0001529_abnormal_vocalization1.41633721
56MP0001485_abnormal_pinna_reflex1.39729186
57MP0008872_abnormal_physiological_respon1.37953355
58MP0003011_delayed_dark_adaptation1.36736681
59MP0001501_abnormal_sleep_pattern1.36642437
60MP0002735_abnormal_chemical_nociception1.35754548
61MP0001905_abnormal_dopamine_level1.35729937
62MP0000609_abnormal_liver_physiology1.35192477
63MP0005408_hypopigmentation1.34994175
64MP0000678_abnormal_parathyroid_gland1.34714552
65MP0000566_synostosis1.34707208
66MP0003878_abnormal_ear_physiology1.33660821
67MP0005377_hearing/vestibular/ear_phenot1.33660821
68MP0003137_abnormal_impulse_conducting1.33604314
69MP0002733_abnormal_thermal_nociception1.32575298
70MP0002063_abnormal_learning/memory/cond1.29899807
71MP0005395_other_phenotype1.28690320
72MP0006054_spinal_hemorrhage1.27760346
73MP0002876_abnormal_thyroid_physiology1.26339379
74MP0001764_abnormal_homeostasis1.25230371
75MP0005319_abnormal_enzyme/_coenzyme1.24998751
76MP0003191_abnormal_cellular_cholesterol1.23891779
77MP0003879_abnormal_hair_cell1.22395756
78MP0009697_abnormal_copulation1.22036705
79MP0003941_abnormal_skin_development1.19191493
80MP0000383_abnormal_hair_follicle1.18906054
81MP0000462_abnormal_digestive_system1.17980143
82MP0010030_abnormal_orbit_morphology1.16155170
83MP0002557_abnormal_social/conspecific_i1.15652059
84MP0003329_amyloid_beta_deposits1.13174745
85MP0003656_abnormal_erythrocyte_physiolo1.11410592
86MP0003868_abnormal_feces_composition1.09670372
87MP0010386_abnormal_urinary_bladder1.09572832
88MP0000427_abnormal_hair_cycle1.08494086
89MP0004264_abnormal_extraembryonic_tissu1.08051492
90MP0002067_abnormal_sensory_capabilities1.07731758
91MP0004957_abnormal_blastocyst_morpholog1.06736405
92MP0005167_abnormal_blood-brain_barrier1.06136490
93MP0001502_abnormal_circadian_rhythm1.05944635
94MP0008789_abnormal_olfactory_epithelium1.04451643
95MP0001963_abnormal_hearing_physiology1.04326746
96MP0005266_abnormal_metabolism1.03805664
97MP0000230_abnormal_systemic_arterial1.02430581
98MP0002254_reproductive_system_inflammat1.01995128
99MP0005636_abnormal_mineral_homeostasis1.01405600
100MP0002295_abnormal_pulmonary_circulatio1.01000631
101MP0002249_abnormal_larynx_morphology1.00739524
102MP0005253_abnormal_eye_physiology1.00152429
103MP0001119_abnormal_female_reproductive0.99652769
104MP0000026_abnormal_inner_ear0.99076771
105MP0008775_abnormal_heart_ventricle0.98506131
106MP0000613_abnormal_salivary_gland0.98099468
107MP0004782_abnormal_surfactant_physiolog0.97806168
108MP0000598_abnormal_liver_morphology0.97715734
109MP0000639_abnormal_adrenal_gland0.97699945
110MP0005410_abnormal_fertilization0.97584774
111MP0002160_abnormal_reproductive_system0.97178271
112MP0005584_abnormal_enzyme/coenzyme_acti0.97173004
113MP0004142_abnormal_muscle_tone0.96130610
114MP0002229_neurodegeneration0.95914790
115MP0005503_abnormal_tendon_morphology0.95432099
116MP0000538_abnormal_urinary_bladder0.94483974
117MP0005058_abnormal_lysosome_morphology0.94021306
118MP0009384_cardiac_valve_regurgitation0.93541083
119MP0001756_abnormal_urination0.92044381
120MP0002837_dystrophic_cardiac_calcinosis0.92039564
121MP0003699_abnormal_female_reproductive0.91198374
122MP0004085_abnormal_heartbeat0.91090180
123MP0003123_paternal_imprinting0.89650408
124MP0002909_abnormal_adrenal_gland0.89540221
125MP0002138_abnormal_hepatobiliary_system0.89162817
126MP0008438_abnormal_cutaneous_collagen0.88776754
127MP0005646_abnormal_pituitary_gland0.88231464
128MP0005084_abnormal_gallbladder_morpholo0.86022329
129MP0000647_abnormal_sebaceous_gland0.85558885
130MP0004272_abnormal_basement_membrane0.84442430
131MP0003705_abnormal_hypodermis_morpholog0.81689016
132MP0003638_abnormal_response/metabolism_0.81344489
133MP0005394_taste/olfaction_phenotype0.80840242
134MP0005499_abnormal_olfactory_system0.80840242
135MP0002269_muscular_atrophy0.80619905
136MP0002653_abnormal_ependyma_morphology0.80218406
137MP0008569_lethality_at_weaning0.79473630
138MP0001944_abnormal_pancreas_morphology0.79062450
139MP0002127_abnormal_cardiovascular_syste0.78917278
140MP0005376_homeostasis/metabolism_phenot0.78887420
141MP0005386_behavior/neurological_phenoty0.76990845
142MP0004924_abnormal_behavior0.76990845
143MP0005275_abnormal_skin_tensile0.76780318
144MP0000749_muscle_degeneration0.75272722
145MP0001986_abnormal_taste_sensitivity0.75090269
146MP0002078_abnormal_glucose_homeostasis0.73906909
147MP0002332_abnormal_exercise_endurance0.72452674
148MP0001440_abnormal_grooming_behavior0.72076947
149MP0003787_abnormal_imprinting0.71854413
150MP0002090_abnormal_vision0.70978210
151MP0005330_cardiomyopathy0.69779554
152MP0002752_abnormal_somatic_nervous0.69513177
153MP0005666_abnormal_adipose_tissue0.69427641
154MP0004036_abnormal_muscle_relaxation0.68650817
155MP0002132_abnormal_respiratory_system0.68173280
156MP0005647_abnormal_sex_gland0.67860923
157MP0008260_abnormal_autophagy0.67264119
158MP0008932_abnormal_embryonic_tissue0.63083804
159MP0009642_abnormal_blood_homeostasis0.62468209
160MP0000653_abnormal_sex_gland0.60813628
161MP0009763_increased_sensitivity_to0.60124892
162MP0003077_abnormal_cell_cycle0.59493986
163MP0005379_endocrine/exocrine_gland_phen0.59463738
164MP0006292_abnormal_olfactory_placode0.59051465
165MP0004185_abnormal_adipocyte_glucose0.58811748
166MP0003942_abnormal_urinary_system0.58626619
167MP0003950_abnormal_plasma_membrane0.58074921
168MP0005595_abnormal_vascular_smooth0.57540584
169MP0003937_abnormal_limbs/digits/tail_de0.56460875
170MP0002136_abnormal_kidney_physiology0.54539422
171MP0006138_congestive_heart_failure0.54348179
172MP0002938_white_spotting0.54125287
173MP0004084_abnormal_cardiac_muscle0.54118222
174MP0003119_abnormal_digestive_system0.54112375
175MP0005023_abnormal_wound_healing0.53286655
176MP0005165_increased_susceptibility_to0.53282905
177MP0002972_abnormal_cardiac_muscle0.53148541
178MP0002877_abnormal_melanocyte_morpholog0.52605706

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.34550646
2Hypoglycemic coma (HP:0001325)5.11710667
3Intrahepatic cholestasis (HP:0001406)4.51245932
4Hyperglycinuria (HP:0003108)4.13892901
5Ketoacidosis (HP:0001993)4.03601383
6Ketosis (HP:0001946)3.94866697
7Deep venous thrombosis (HP:0002625)3.87103148
8Myokymia (HP:0002411)3.79452248
9Xanthomatosis (HP:0000991)3.77480367
10Hyperammonemia (HP:0001987)3.71817142
11Abnormality of glycine metabolism (HP:0010895)3.69768198
12Abnormality of serine family amino acid metabolism (HP:0010894)3.69768198
13Generalized aminoaciduria (HP:0002909)3.63916083
14Hypoglycemic seizures (HP:0002173)3.56017967
15Hyperglycinemia (HP:0002154)3.51428162
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.42960965
17Abnormality of fatty-acid metabolism (HP:0004359)3.35009990
18Hypobetalipoproteinemia (HP:0003563)3.31981773
19Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.29748346
20True hermaphroditism (HP:0010459)3.28897077
21Abnormality of dicarboxylic acid metabolism (HP:0010995)3.23993408
22Dicarboxylic aciduria (HP:0003215)3.23993408
23Hyperlipoproteinemia (HP:0010980)3.23089340
24Late onset (HP:0003584)3.21567450
25Hyperinsulinemic hypoglycemia (HP:0000825)3.03703192
26Hepatic necrosis (HP:0002605)2.97851887
27Abnormality of aspartate family amino acid metabolism (HP:0010899)2.95844086
28Acute necrotizing encephalopathy (HP:0006965)2.95635138
29Abnormality of methionine metabolism (HP:0010901)2.94321159
30Abnormality of serum amino acid levels (HP:0003112)2.90388399
31Lethargy (HP:0001254)2.87061697
32Prolonged partial thromboplastin time (HP:0003645)2.83075681
33Pancreatic cysts (HP:0001737)2.78090751
34Pancreatic fibrosis (HP:0100732)2.76211533
35Abnormality of the intrinsic pathway (HP:0010989)2.74285148
36Abnormality of sulfur amino acid metabolism (HP:0004339)2.71900253
37Hypolipoproteinemia (HP:0010981)2.70887994
38Abnormal mitochondria in muscle tissue (HP:0008316)2.70032712
39Testicular atrophy (HP:0000029)2.68412344
40Glycosuria (HP:0003076)2.67766004
41Abnormality of urine glucose concentration (HP:0011016)2.67766004
42Proximal tubulopathy (HP:0000114)2.64461809
43Mitochondrial inheritance (HP:0001427)2.59314137
44Medial flaring of the eyebrow (HP:0010747)2.58278242
45Abnormality of midbrain morphology (HP:0002418)2.56545364
46Molar tooth sign on MRI (HP:0002419)2.56545364
47Metabolic acidosis (HP:0001942)2.56143451
48Polyphagia (HP:0002591)2.55987344
49Fat malabsorption (HP:0002630)2.53468934
50Delayed CNS myelination (HP:0002188)2.52986709
51Symptomatic seizures (HP:0011145)2.52737087
52Hyperbilirubinemia (HP:0002904)2.50753679
53Gait imbalance (HP:0002141)2.48690313
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.48670385
55Hypoalphalipoproteinemia (HP:0003233)2.46621211
56Progressive macrocephaly (HP:0004481)2.45755558
57Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.45494233
58Congenital, generalized hypertrichosis (HP:0004540)2.40955158
59Hyperglycemia (HP:0003074)2.38053243
60Ulnar claw (HP:0001178)2.34770890
61Methylmalonic acidemia (HP:0002912)2.33646343
62Nephrogenic diabetes insipidus (HP:0009806)2.33407611
63Brushfield spots (HP:0001088)2.32148491
64Increased CSF lactate (HP:0002490)2.31659758
65Acute encephalopathy (HP:0006846)2.29651771
66Increased serum pyruvate (HP:0003542)2.29264448
67Abnormality of glycolysis (HP:0004366)2.29264448
68Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.28952725
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.28952725
70Nausea (HP:0002018)2.26980870
71Gout (HP:0001997)2.26838418
72Cerebral edema (HP:0002181)2.25853027
73Increased muscle lipid content (HP:0009058)2.25065787
74Nephronophthisis (HP:0000090)2.23907159
75Congenital primary aphakia (HP:0007707)2.21397820
76Congenital stationary night blindness (HP:0007642)2.21366419
77Conjugated hyperbilirubinemia (HP:0002908)2.20457363
78Abnormality of the pancreatic islet cells (HP:0006476)2.19876304
79Abnormality of endocrine pancreas physiology (HP:0012093)2.19876304
80Abnormality of binocular vision (HP:0011514)2.16480810
81Diplopia (HP:0000651)2.16480810
82Hepatocellular necrosis (HP:0001404)2.14737744
83Male infertility (HP:0003251)2.13664877
84Action tremor (HP:0002345)2.13557736
85Abnormality of purine metabolism (HP:0004352)2.12159399
86Abnormality of nucleobase metabolism (HP:0010932)2.11416348
87Generalized tonic-clonic seizures (HP:0002069)2.10637269
88Hemiparesis (HP:0001269)2.10336281
89Inability to walk (HP:0002540)2.10212555
90Abnormal eating behavior (HP:0100738)2.09934524
91Abnormality of pyrimidine metabolism (HP:0004353)2.09930244
92Progressive inability to walk (HP:0002505)2.06907637
93Abnormality of alanine metabolism (HP:0010916)2.06791627
94Hyperalaninemia (HP:0003348)2.06791627
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06791627
96Focal seizures (HP:0007359)2.06777376
97Complement deficiency (HP:0004431)2.06701269
98Aplasia/Hypoplasia of the tongue (HP:0010295)2.06004575
99Progressive cerebellar ataxia (HP:0002073)2.05593235
100Abnormality of the renal cortex (HP:0011035)2.03660704
101Type II lissencephaly (HP:0007260)2.03184147
102Vomiting (HP:0002013)2.02971246
103CNS demyelination (HP:0007305)2.02477970
104Enlarged kidneys (HP:0000105)2.02305907
105Abnormality of the common coagulation pathway (HP:0010990)2.01543206
106Cystic liver disease (HP:0006706)2.00943762
107Increased intramyocellular lipid droplets (HP:0012240)2.00170134
108Steatorrhea (HP:0002570)1.99855606
109Anencephaly (HP:0002323)1.99652723
110Lactic acidosis (HP:0003128)1.99258905
111Atonic seizures (HP:0010819)1.98873707
112Concave nail (HP:0001598)1.98619271
113Insulin resistance (HP:0000855)1.98321441
114Decreased central vision (HP:0007663)1.97106403
115Tongue fasciculations (HP:0001308)1.96725481
116Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96363039
117Male pseudohermaphroditism (HP:0000037)1.95145271
118Spastic paraparesis (HP:0002313)1.94372000
119Renal cortical cysts (HP:0000803)1.92449833
120Severe muscular hypotonia (HP:0006829)1.92134747
121Sclerocornea (HP:0000647)1.91017853
122Opisthotonus (HP:0002179)1.90323251
123Secondary amenorrhea (HP:0000869)1.90163312
124Flat capital femoral epiphysis (HP:0003370)1.89934621
125Methylmalonic aciduria (HP:0012120)1.89581991
126Malnutrition (HP:0004395)1.88846180
127Abolished electroretinogram (ERG) (HP:0000550)1.88384830
128Abnormal cartilage morphology (HP:0002763)1.87707504
129Irritability (HP:0000737)1.86365758
130Breast hypoplasia (HP:0003187)1.85248791
131Vaginal atresia (HP:0000148)1.85026727
132Occipital encephalocele (HP:0002085)1.83882309
133Aplasia/Hypoplasia of the fovea (HP:0008060)1.83560171
134Hypoplasia of the fovea (HP:0007750)1.83560171
135Myoglobinuria (HP:0002913)1.83174762
136Genital tract atresia (HP:0001827)1.83068908
137Pili torti (HP:0003777)1.82896427
138Renal Fanconi syndrome (HP:0001994)1.81921909
139Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81007109
140Progressive neurologic deterioration (HP:0002344)1.80229156
141Respiratory distress (HP:0002098)1.79752309
142Bile duct proliferation (HP:0001408)1.79247389
143Abnormal biliary tract physiology (HP:0012439)1.79247389
144Abnormality of the labia minora (HP:0012880)1.78983509
145Focal motor seizures (HP:0011153)1.77946550
146Epidermoid cyst (HP:0200040)1.77083181
147Abnormality of the renal medulla (HP:0100957)1.76206930
148Pancreatic islet-cell hyperplasia (HP:0004510)1.74864977
149Multiple enchondromatosis (HP:0005701)1.74052792
150Megaloblastic anemia (HP:0001889)1.73891166
151Abnormality of the corticospinal tract (HP:0002492)1.73801437
152Optic disc pallor (HP:0000543)1.72728162
153Oral leukoplakia (HP:0002745)1.72203103
154Bilateral microphthalmos (HP:0007633)1.71884516
155Hyperphosphaturia (HP:0003109)1.71478066
156Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71063478
157Increased serum lactate (HP:0002151)1.70828476
158Hypercholesterolemia (HP:0003124)1.70757914
159Limb dystonia (HP:0002451)1.69540416
160Increased neuronal autofluorescent lipopigment (HP:0002074)1.68679271
161Pancreatitis (HP:0001733)1.68390318
162Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.67947857
163Degeneration of the lateral corticospinal tracts (HP:0002314)1.67947857
164Palpitations (HP:0001962)1.67370356
165Abnormality of the fovea (HP:0000493)1.66871275
166Status epilepticus (HP:0002133)1.65896571
167Poor suck (HP:0002033)1.65044151
168Anxiety (HP:0000739)1.64989460
169Optic nerve hypoplasia (HP:0000609)1.64657341
170Left ventricular hypertrophy (HP:0001712)1.64609743
171Rhabdomyolysis (HP:0003201)1.64165205
172Mesangial abnormality (HP:0001966)1.63612718
173Febrile seizures (HP:0002373)1.63295003
174Syncope (HP:0001279)1.62634768
175Follicular hyperkeratosis (HP:0007502)1.62595519

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.72110086
2STK38L3.35117181
3PDK22.70112286
4ERN12.68929069
5MAPK152.64578493
6MUSK2.55426239
7GRK12.54763513
8BMPR1B2.46373054
9ADRBK22.35948449
10MAP3K62.35035173
11BUB12.24072674
12ERBB42.14585087
13STK162.12950835
14LATS12.12530998
15PASK2.03259984
16INSRR1.98855611
17LMTK21.98677355
18BRAF1.96146956
19PLK41.93217740
20MAP4K21.92721177
21MST41.90890132
22TTK1.90790815
23PRKD31.90449799
24MOS1.85884778
25EPHA41.85798933
26TAOK31.84054088
27TRIB31.76215735
28ARAF1.74577669
29FRK1.69968581
30MAPK131.64903220
31DAPK21.64829409
32NTRK21.63139725
33TRIM281.58668140
34VRK21.58438683
35LATS21.52233069
36TAOK21.46213398
37FLT31.45131179
38PAK61.42570322
39PHKG11.41253509
40PHKG21.41253509
41CAMK2G1.38689419
42ABL21.38539547
43PLK21.37931666
44KSR21.36105817
45MAP2K61.35217487
46PRKCG1.34357205
47STK101.31227884
48WEE11.31151043
49MAP2K21.30712430
50NTRK31.30693498
51GRK51.29325461
52DYRK21.28406193
53CDK81.28241688
54MAP3K81.27782337
55EPHA21.24693688
56CAMK11.18716368
57MET1.18316163
58PAK31.17377649
59BRSK21.15798915
60ADRBK11.14319190
61DAPK11.13720754
62PRKCE1.12248528
63EIF2AK11.11676154
64PTK2B1.11272615
65ACVR1B1.10625744
66SIK11.08995681
67CAMK2D1.08320101
68CAMK2B1.06600842
69OBSCN1.05203118
70CAMK2A1.04878767
71NME21.04262634
72WNK31.03275280
73NEK61.01352239
74KDR0.98339255
75TIE10.97229590
76MARK10.96427643
77MAP3K30.95768753
78PNCK0.94913465
79PIK3CA0.93334465
80MAP3K110.91946968
81PINK10.91534843
82MAPKAPK30.91211203
83MYLK0.89252486
84TESK20.88321904
85MAP3K120.87890682
86MINK10.84804926
87OXSR10.83817793
88PLK10.82478669
89RAF10.80571619
90JAK30.79927196
91DAPK30.79232407
92EIF2AK30.78962006
93PLK30.78256814
94AURKA0.78233549
95LIMK10.77759844
96BMPR20.77116745
97TNK20.76779891
98MKNK20.76766551
99PKN20.75244131
100MAP3K130.74452307
101PKN10.71895940
102TLK10.70968932
103TGFBR10.70658864
104PRKD20.70425273
105PIM20.70409575
106CHEK20.69474143
107BMX0.69378251
108NLK0.67824810
109VRK10.67497731
110STK390.66232119
111TNIK0.66153170
112PBK0.65474693
113TYRO30.65239549
114MAPK110.64735004
115MAP2K70.64526040
116ROCK10.63863476
117AURKB0.63607960
118WNK40.63455500
119ZAK0.63145017
120RPS6KB20.62812289
121PRKCA0.62188391
122MAP2K10.62128923
123CSNK1G20.61458873
124STK30.61147814
125FER0.61037402
126CDK70.57081678
127MELK0.56607581
128MAPKAPK50.56444506
129UHMK10.56294457
130MAP3K50.55995412
131HIPK20.55479350
132NEK90.53457763
133MAP2K30.52846214
134PRKD10.52143649
135PRKACA0.52028218
136PRKCZ0.51736939
137IRAK30.51298502
138PRKG20.50685773
139PIK3CG0.50152616
140ILK0.50101588
141PDK40.49839082
142PDK30.49839082
143CSNK1G10.49609370
144TESK10.49494613
145CSNK1A10.47867948
146MAP3K40.46813860
147LRRK20.46706990
148NEK20.45725058
149RPS6KA40.45633141
150CAMKK10.44628688
151NTRK10.44150315
152CDK50.43340343
153PRKCI0.42074785
154PTK20.41696254
155MARK30.41627705
156NUAK10.38044877
157PRKAA20.38021429
158TYK20.36309144
159DYRK30.32388827
160BRSK10.31566918
161CSNK1G30.30874140
162CDK90.28962913
163CDC70.27663801

Predicted pathways (KEGG)

RankGene SetZ-score
1Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.66344601
2Nitrogen metabolism_Homo sapiens_hsa009102.61473590
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.61405033
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.50281846
5Fatty acid degradation_Homo sapiens_hsa000712.46856216
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45341846
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.42127998
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.29688621
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.26736270
10Propanoate metabolism_Homo sapiens_hsa006402.26544493
11Folate biosynthesis_Homo sapiens_hsa007902.21215516
12Peroxisome_Homo sapiens_hsa041462.07534291
13Tryptophan metabolism_Homo sapiens_hsa003801.98720392
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97658247
15Selenocompound metabolism_Homo sapiens_hsa004501.97413545
16Nicotine addiction_Homo sapiens_hsa050331.96330938
17Protein export_Homo sapiens_hsa030601.92734095
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.91982886
19Butanoate metabolism_Homo sapiens_hsa006501.84409061
20Fatty acid metabolism_Homo sapiens_hsa012121.83478571
21Sulfur metabolism_Homo sapiens_hsa009201.81475989
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.76608486
23Fatty acid elongation_Homo sapiens_hsa000621.69154749
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.64506236
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60113301
26Histidine metabolism_Homo sapiens_hsa003401.57747155
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56867219
28Sulfur relay system_Homo sapiens_hsa041221.56150923
29Cardiac muscle contraction_Homo sapiens_hsa042601.52092327
30Arginine biosynthesis_Homo sapiens_hsa002201.49723958
31Chemical carcinogenesis_Homo sapiens_hsa052041.48211470
32Pyruvate metabolism_Homo sapiens_hsa006201.47556853
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43188270
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.39949472
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39784855
36Arginine and proline metabolism_Homo sapiens_hsa003301.39617433
37Complement and coagulation cascades_Homo sapiens_hsa046101.39244658
38PPAR signaling pathway_Homo sapiens_hsa033201.38151276
39Glutathione metabolism_Homo sapiens_hsa004801.38020242
40beta-Alanine metabolism_Homo sapiens_hsa004101.37635437
41Carbon metabolism_Homo sapiens_hsa012001.36427042
42Synaptic vesicle cycle_Homo sapiens_hsa047211.36050356
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.34937857
44Biosynthesis of amino acids_Homo sapiens_hsa012301.33968160
45Phototransduction_Homo sapiens_hsa047441.29462153
46Vitamin B6 metabolism_Homo sapiens_hsa007501.25469181
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24861251
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23398229
49Alzheimers disease_Homo sapiens_hsa050101.22801268
50Retinol metabolism_Homo sapiens_hsa008301.22166560
51Steroid biosynthesis_Homo sapiens_hsa001001.21775218
52Collecting duct acid secretion_Homo sapiens_hsa049661.20420903
53Insulin secretion_Homo sapiens_hsa049111.17486972
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16499068
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16247817
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.16147819
57One carbon pool by folate_Homo sapiens_hsa006701.15454215
58RNA polymerase_Homo sapiens_hsa030201.15117150
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13928280
60Circadian entrainment_Homo sapiens_hsa047131.13904887
61GABAergic synapse_Homo sapiens_hsa047271.12149803
62Morphine addiction_Homo sapiens_hsa050321.11483818
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09003159
64Starch and sucrose metabolism_Homo sapiens_hsa005001.08455506
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07280378
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07158541
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06266425
68Glutamatergic synapse_Homo sapiens_hsa047241.02397297
69Fat digestion and absorption_Homo sapiens_hsa049751.02172246
70Linoleic acid metabolism_Homo sapiens_hsa005911.00535177
71Tyrosine metabolism_Homo sapiens_hsa003500.98411038
72Caffeine metabolism_Homo sapiens_hsa002320.97028534
73Pyrimidine metabolism_Homo sapiens_hsa002400.96543490
74Olfactory transduction_Homo sapiens_hsa047400.96140709
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95872185
76Galactose metabolism_Homo sapiens_hsa000520.94044048
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92942850
78Amphetamine addiction_Homo sapiens_hsa050310.88230720
79Vitamin digestion and absorption_Homo sapiens_hsa049770.87879939
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87690274
81Phenylalanine metabolism_Homo sapiens_hsa003600.85382714
82Mismatch repair_Homo sapiens_hsa034300.84049355
83Serotonergic synapse_Homo sapiens_hsa047260.83981476
84Metabolic pathways_Homo sapiens_hsa011000.83652519
85Proteasome_Homo sapiens_hsa030500.83021257
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82693039
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82526370
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82379103
89DNA replication_Homo sapiens_hsa030300.81527039
90Mineral absorption_Homo sapiens_hsa049780.80765889
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77138356
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76570723
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76245151
94Other glycan degradation_Homo sapiens_hsa005110.75599861
95Taste transduction_Homo sapiens_hsa047420.74224235
96Gastric acid secretion_Homo sapiens_hsa049710.69867024
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69689919
98Arachidonic acid metabolism_Homo sapiens_hsa005900.68434722
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68011263
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67405820
101Dopaminergic synapse_Homo sapiens_hsa047280.67241194
102Pentose phosphate pathway_Homo sapiens_hsa000300.66957293
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.66356296
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.63527771
105Salivary secretion_Homo sapiens_hsa049700.63402292
106Calcium signaling pathway_Homo sapiens_hsa040200.62948994
107Lysine degradation_Homo sapiens_hsa003100.62037188
108Fructose and mannose metabolism_Homo sapiens_hsa000510.59786876
109Cocaine addiction_Homo sapiens_hsa050300.58345510
110RNA degradation_Homo sapiens_hsa030180.57591742
111Base excision repair_Homo sapiens_hsa034100.57510733
112Homologous recombination_Homo sapiens_hsa034400.57413526
113Oxidative phosphorylation_Homo sapiens_hsa001900.57349075
114ABC transporters_Homo sapiens_hsa020100.56818548
115Bile secretion_Homo sapiens_hsa049760.56741088
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55793645
117Glycerolipid metabolism_Homo sapiens_hsa005610.53611608
118Parkinsons disease_Homo sapiens_hsa050120.52705655
119Basal transcription factors_Homo sapiens_hsa030220.52527133
120Hedgehog signaling pathway_Homo sapiens_hsa043400.52380716
121Nucleotide excision repair_Homo sapiens_hsa034200.51603025
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51286422
123cAMP signaling pathway_Homo sapiens_hsa040240.50611606
124Hippo signaling pathway_Homo sapiens_hsa043900.48907144
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48056916
126Purine metabolism_Homo sapiens_hsa002300.46381932
127N-Glycan biosynthesis_Homo sapiens_hsa005100.45900944
128Fatty acid biosynthesis_Homo sapiens_hsa000610.45501419
129Ovarian steroidogenesis_Homo sapiens_hsa049130.44040810
130Cell cycle_Homo sapiens_hsa041100.43922544
131Ether lipid metabolism_Homo sapiens_hsa005650.43254214
132Huntingtons disease_Homo sapiens_hsa050160.39599630
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.31796611
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.30360964
135Staphylococcus aureus infection_Homo sapiens_hsa051500.28310718
136RNA transport_Homo sapiens_hsa030130.28024735
137Regulation of autophagy_Homo sapiens_hsa041400.27392337

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