Rank | Gene Set | Z-score |
---|---|---|
1 | phospholipid homeostasis (GO:0055091) | 4.97511830 |
2 | urea cycle (GO:0000050) | 4.25477761 |
3 | urea metabolic process (GO:0019627) | 4.25477761 |
4 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 4.20676741 |
5 | L-phenylalanine catabolic process (GO:0006559) | 4.20676741 |
6 | alpha-linolenic acid metabolic process (GO:0036109) | 3.98023923 |
7 | aromatic amino acid family catabolic process (GO:0009074) | 3.97080588 |
8 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 3.96832580 |
9 | negative regulation of interleukin-12 production (GO:0032695) | 3.95706504 |
10 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 3.92770479 |
11 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 3.91782985 |
12 | L-phenylalanine metabolic process (GO:0006558) | 3.91782985 |
13 | regulation of cholesterol homeostasis (GO:2000188) | 3.82199637 |
14 | tryptophan catabolic process (GO:0006569) | 3.80014387 |
15 | indole-containing compound catabolic process (GO:0042436) | 3.80014387 |
16 | indolalkylamine catabolic process (GO:0046218) | 3.80014387 |
17 | kynurenine metabolic process (GO:0070189) | 3.78778683 |
18 | phospholipid efflux (GO:0033700) | 3.76700863 |
19 | tryptophan metabolic process (GO:0006568) | 3.74722719 |
20 | nitrogen cycle metabolic process (GO:0071941) | 3.73192153 |
21 | cellular response to ethanol (GO:0071361) | 3.72212218 |
22 | complement activation, alternative pathway (GO:0006957) | 3.67493454 |
23 | dicarboxylic acid biosynthetic process (GO:0043650) | 3.62919972 |
24 | high-density lipoprotein particle remodeling (GO:0034375) | 3.60847995 |
25 | negative regulation of fibrinolysis (GO:0051918) | 3.60632028 |
26 | response to type I interferon (GO:0034340) | 3.55276835 |
27 | type I interferon signaling pathway (GO:0060337) | 3.52278721 |
28 | cellular response to type I interferon (GO:0071357) | 3.52278721 |
29 | peptidyl-glutamic acid carboxylation (GO:0017187) | 3.50870369 |
30 | protein carboxylation (GO:0018214) | 3.50870369 |
31 | regulation of protein activation cascade (GO:2000257) | 3.50368502 |
32 | macrophage activation involved in immune response (GO:0002281) | 3.48902865 |
33 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.43768195 |
34 | positive regulation of fatty acid beta-oxidation (GO:0032000) | 3.42985737 |
35 | regulation of cholesterol storage (GO:0010885) | 3.41041106 |
36 | plasma lipoprotein particle clearance (GO:0034381) | 3.40694608 |
37 | reverse cholesterol transport (GO:0043691) | 3.38294551 |
38 | plasma lipoprotein particle assembly (GO:0034377) | 3.37501553 |
39 | glycosphingolipid catabolic process (GO:0046479) | 3.34989555 |
40 | cholesterol efflux (GO:0033344) | 3.34566943 |
41 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.32254544 |
42 | protein-lipid complex assembly (GO:0065005) | 3.30312023 |
43 | response to peptidoglycan (GO:0032494) | 3.29627037 |
44 | bile acid biosynthetic process (GO:0006699) | 3.28920057 |
45 | macroautophagy (GO:0016236) | 3.28619220 |
46 | regulation of complement activation (GO:0030449) | 3.28141361 |
47 | serine family amino acid catabolic process (GO:0009071) | 3.27055689 |
48 | negative regulation of cholesterol transport (GO:0032375) | 3.26507979 |
49 | negative regulation of sterol transport (GO:0032372) | 3.26507979 |
50 | protein-lipid complex remodeling (GO:0034368) | 3.25447288 |
51 | macromolecular complex remodeling (GO:0034367) | 3.25447288 |
52 | plasma lipoprotein particle remodeling (GO:0034369) | 3.25447288 |
53 | cysteine metabolic process (GO:0006534) | 3.24306084 |
54 | regulation of cholesterol esterification (GO:0010872) | 3.21995200 |
55 | low-density lipoprotein particle remodeling (GO:0034374) | 3.16818735 |
56 | regulation of fatty acid beta-oxidation (GO:0031998) | 3.16365829 |
57 | regulation of triglyceride catabolic process (GO:0010896) | 3.14396345 |
58 | glyoxylate metabolic process (GO:0046487) | 3.13912557 |
59 | positive regulation of lipid catabolic process (GO:0050996) | 3.13877405 |
60 | oligosaccharide catabolic process (GO:0009313) | 3.13760029 |
61 | bile acid metabolic process (GO:0008206) | 3.12813141 |
62 | regulation of fibrinolysis (GO:0051917) | 3.12248722 |
63 | homocysteine metabolic process (GO:0050667) | 3.12005752 |
64 | germinal center formation (GO:0002467) | 3.11477825 |
65 | sulfur amino acid catabolic process (GO:0000098) | 3.10203084 |
66 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.08999004 |
67 | positive regulation of cholesterol transport (GO:0032376) | 3.01093672 |
68 | positive regulation of sterol transport (GO:0032373) | 3.01093672 |
69 | amino-acid betaine metabolic process (GO:0006577) | 3.00260809 |
70 | low-density lipoprotein particle clearance (GO:0034383) | 2.98355216 |
71 | glycolipid catabolic process (GO:0019377) | 2.96489145 |
72 | plasma lipoprotein particle organization (GO:0071827) | 2.94497278 |
73 | regulation of T-helper 1 cell differentiation (GO:0045625) | 2.94378451 |
74 | positive regulation of cholesterol efflux (GO:0010875) | 2.93282190 |
75 | protein-lipid complex subunit organization (GO:0071825) | 2.93097181 |
76 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 2.93012685 |
77 | negative regulation of cell killing (GO:0031342) | 2.93012685 |
78 | regulation of gamma-delta T cell activation (GO:0046643) | 2.91388122 |
79 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 2.90303354 |
80 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 2.90303354 |
81 | modulation by symbiont of host immune response (GO:0052553) | 2.90303354 |
82 | positive regulation by symbiont of host defense response (GO:0052509) | 2.90303354 |
83 | modulation by symbiont of host defense response (GO:0052031) | 2.90303354 |
84 | detection of molecule of bacterial origin (GO:0032490) | 2.88628161 |
85 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.87801901 |
86 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 2.86359710 |
87 | lipoprotein metabolic process (GO:0042157) | 2.85956640 |
88 | valine metabolic process (GO:0006573) | 2.83746549 |
89 | tyrosine metabolic process (GO:0006570) | 2.83378408 |
90 | cholesterol homeostasis (GO:0042632) | 2.82758007 |
91 | regulation of vitamin D biosynthetic process (GO:0060556) | 2.81708285 |
92 | positive regulation of interferon-alpha production (GO:0032727) | 2.81288542 |
93 | mannose metabolic process (GO:0006013) | 2.80496933 |
94 | negative regulation of lipid transport (GO:0032369) | 2.80271561 |
95 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.80126722 |
96 | sterol homeostasis (GO:0055092) | 2.79759750 |
97 | response to muramyl dipeptide (GO:0032495) | 2.79365026 |
98 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.79133013 |
99 | aromatic amino acid family metabolic process (GO:0009072) | 2.78884999 |
100 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 2.78485953 |
101 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 2.78485953 |
102 | glycine metabolic process (GO:0006544) | 2.76195738 |
103 | lysine metabolic process (GO:0006553) | 2.74153370 |
104 | lysine catabolic process (GO:0006554) | 2.74153370 |
105 | very-low-density lipoprotein particle assembly (GO:0034379) | 2.73973337 |
106 | acylglycerol homeostasis (GO:0055090) | 2.73093844 |
107 | triglyceride homeostasis (GO:0070328) | 2.73093844 |
108 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 2.72608336 |
109 | N-acetylneuraminate metabolic process (GO:0006054) | 2.72459255 |
110 | negative regulation of macrophage derived foam cell differentiation (GO:0010745) | 2.71421183 |
111 | cellular response to exogenous dsRNA (GO:0071360) | 2.70449670 |
112 | detection of other organism (GO:0098543) | 2.70256194 |
113 | regulation of protein polyubiquitination (GO:1902914) | 2.70148630 |
114 | regulation of sterol transport (GO:0032371) | 2.65364901 |
115 | regulation of cholesterol transport (GO:0032374) | 2.65364901 |
116 | indolalkylamine metabolic process (GO:0006586) | 2.64975613 |
117 | regulation of membrane protein ectodomain proteolysis (GO:0051043) | 2.64128279 |
118 | cellular response to thyroid hormone stimulus (GO:0097067) | 2.64051700 |
119 | regulation of interferon-alpha production (GO:0032647) | 2.63954815 |
120 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.63937220 |
121 | antigen processing and presentation of endogenous antigen (GO:0019883) | 2.63615000 |
122 | negative regulation of cytokine production involved in immune response (GO:0002719) | 2.63576778 |
123 | negative regulation of lipid storage (GO:0010888) | 2.63215684 |
124 | ceramide catabolic process (GO:0046514) | 2.63122160 |
125 | alpha-amino acid catabolic process (GO:1901606) | 2.62795871 |
126 | positive regulation of histone deacetylation (GO:0031065) | 2.62386286 |
127 | myeloid dendritic cell differentiation (GO:0043011) | 2.59757497 |
128 | complement activation, classical pathway (GO:0006958) | 2.59421953 |
129 | ethanol oxidation (GO:0006069) | 2.58744206 |
130 | bile acid and bile salt transport (GO:0015721) | 2.58547232 |
131 | cytoplasmic mRNA processing body assembly (GO:0033962) | 2.57812125 |
132 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 2.57048821 |
133 | negative regulation of fatty acid biosynthetic process (GO:0045717) | 2.56771384 |
134 | negative regulation of lipase activity (GO:0060192) | 2.56034938 |
135 | lipoprotein transport (GO:0042953) | 2.56030186 |
136 | amino sugar catabolic process (GO:0046348) | 2.55214229 |
137 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 2.55088530 |
138 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 2.54397875 |
139 | regulation of MHC class I biosynthetic process (GO:0045343) | 2.53912179 |
140 | iron ion import (GO:0097286) | 2.53583251 |
141 | positive regulation of antigen processing and presentation (GO:0002579) | 2.52495108 |
142 | detection of external biotic stimulus (GO:0098581) | 2.51195727 |
143 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 2.50847456 |
144 | regulation of cytokine secretion involved in immune response (GO:0002739) | 2.50197843 |
145 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 2.49624597 |
146 | NIK/NF-kappaB signaling (GO:0038061) | 2.48991100 |
147 | T-helper 1 type immune response (GO:0042088) | 2.48466111 |
148 | regulation of antigen processing and presentation (GO:0002577) | 2.47671771 |
149 | cellular extravasation (GO:0045123) | 2.47367942 |
150 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 2.47097277 |
151 | immunoglobulin mediated immune response (GO:0016064) | 2.46213794 |
152 | regulation of interleukin-12 production (GO:0032655) | 2.42119090 |
153 | protein localization to endosome (GO:0036010) | 2.42095337 |
154 | positive regulation of interferon-beta production (GO:0032728) | 2.41416796 |
155 | detection of bacterium (GO:0016045) | 2.40546895 |
156 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 2.38442075 |
157 | histone H3-K36 demethylation (GO:0070544) | 2.36446939 |
158 | positive regulation of type 2 immune response (GO:0002830) | 2.35259394 |
159 | positive regulation of cellular amide metabolic process (GO:0034250) | 2.35170271 |
160 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.34370975 |
161 | regulation of T cell tolerance induction (GO:0002664) | 2.34267817 |
162 | defense response to protozoan (GO:0042832) | 2.34251272 |
163 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.33906450 |
164 | regulation of interferon-beta production (GO:0032648) | 2.33863125 |
165 | regulation of necroptotic process (GO:0060544) | 2.33403360 |
166 | response to protozoan (GO:0001562) | 2.32468374 |
167 | macrophage activation (GO:0042116) | 2.31203604 |
168 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 2.29092034 |
169 | pinocytosis (GO:0006907) | 2.28936144 |
170 | cellular response to interferon-alpha (GO:0035457) | 2.24143655 |
171 | positive regulation of heat generation (GO:0031652) | 2.22924642 |
172 | detection of biotic stimulus (GO:0009595) | 2.22416363 |
173 | positive regulation of leukocyte degranulation (GO:0043302) | 2.20421118 |
174 | negative regulation of T cell mediated immunity (GO:0002710) | 2.20417006 |
175 | positive regulation of natural killer cell activation (GO:0032816) | 2.19907296 |
176 | regulation of mononuclear cell migration (GO:0071675) | 2.19583914 |
177 | regulation of response to interferon-gamma (GO:0060330) | 2.19508763 |
178 | myeloid dendritic cell activation (GO:0001773) | 2.18499179 |
179 | negative regulation of toll-like receptor 4 signaling pathway (GO:0034144) | 2.17475794 |
180 | neutrophil activation involved in immune response (GO:0002283) | 2.16866160 |
181 | regulation of type 2 immune response (GO:0002828) | 2.16151493 |
182 | response to lipoprotein particle (GO:0055094) | 2.15833796 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 5.91911054 |
2 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 4.44794118 |
3 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 4.11611211 |
4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 3.83434692 |
5 | * IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.81349201 |
6 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 3.17789718 |
7 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.97082671 |
8 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.77659022 |
9 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 2.67971508 |
10 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 2.63120143 |
11 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.51622926 |
12 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.39193196 |
13 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.38690075 |
14 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.37865032 |
15 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.35199438 |
16 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.25425494 |
17 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.20903653 |
18 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.19204924 |
19 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.17602599 |
20 | * CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 2.16698440 |
21 | GATA1_22025678_ChIP-Seq_K562_Human | 2.14927477 |
22 | MYC_22102868_ChIP-Seq_BL_Human | 2.07944282 |
23 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.06192174 |
24 | * CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.90915986 |
25 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.83177546 |
26 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.81213964 |
27 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.79971649 |
28 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.79874227 |
29 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.79475118 |
30 | * IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.78012978 |
31 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.71537497 |
32 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.71519714 |
33 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.68948719 |
34 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.67035957 |
35 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.63718368 |
36 | * E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.63650865 |
37 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.61762196 |
38 | MAF_26560356_Chip-Seq_TH1_Human | 1.58370831 |
39 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.57769226 |
40 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.51119243 |
41 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.50897252 |
42 | MYB_26560356_Chip-Seq_TH1_Human | 1.49727880 |
43 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.49509609 |
44 | SPI1_23127762_ChIP-Seq_K562_Human | 1.48479387 |
45 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.48174565 |
46 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.48120971 |
47 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.46574821 |
48 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.46307178 |
49 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.44150475 |
50 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.42462508 |
51 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.40156180 |
52 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.39993785 |
53 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.39708975 |
54 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.35967270 |
55 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.34037410 |
56 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.31132922 |
57 | UTX_26944678_Chip-Seq_JUKART_Human | 1.27757285 |
58 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.26271407 |
59 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.24390344 |
60 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.24123142 |
61 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.24092148 |
62 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.23195249 |
63 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.23148577 |
64 | TP53_16413492_ChIP-PET_HCT116_Human | 1.22721455 |
65 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.22713364 |
66 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.22308432 |
67 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.21457468 |
68 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.20949327 |
69 | GATA1_19941826_ChIP-Seq_K562_Human | 1.19974175 |
70 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.19598961 |
71 | MYB_26560356_Chip-Seq_TH2_Human | 1.19241219 |
72 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.18410329 |
73 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.17243403 |
74 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.15055443 |
75 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.14485650 |
76 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.12946826 |
77 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.12547403 |
78 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.11567911 |
79 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.11324851 |
80 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.10183415 |
81 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.09985010 |
82 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.09598230 |
83 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.08182889 |
84 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.07235823 |
85 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.07128118 |
86 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.05843873 |
87 | GATA6_25053715_ChIP-Seq_YYC3_Human | 1.04852414 |
88 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.04289336 |
89 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.01055224 |
90 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.00324478 |
91 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.99938918 |
92 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.99938918 |
93 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.99180801 |
94 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.97900239 |
95 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.96525542 |
96 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.95461596 |
97 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.94620672 |
98 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.94039835 |
99 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.92880723 |
100 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.92547647 |
101 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.92443528 |
102 | GATA3_27048872_Chip-Seq_THYMUS_Human | 0.92100990 |
103 | GATA2_19941826_ChIP-Seq_K562_Human | 0.91133060 |
104 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.90461332 |
105 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.90251938 |
106 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.90171712 |
107 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.90068835 |
108 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.89771571 |
109 | KDM2B_26808549_Chip-Seq_K562_Human | 0.88713620 |
110 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.88053783 |
111 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.88045696 |
112 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.87596816 |
113 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.87473226 |
114 | MAF_26560356_Chip-Seq_TH2_Human | 0.87359228 |
115 | * SPI1_23547873_ChIP-Seq_NB4_Human | 0.86025858 |
116 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.85811844 |
117 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.84784804 |
118 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.84188288 |
119 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.84188288 |
120 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.84148171 |
121 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.83762947 |
122 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.82765724 |
123 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.82496275 |
124 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.82277799 |
125 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.81689672 |
126 | * TFEB_21752829_ChIP-Seq_HELA_Human | 0.81467701 |
127 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.81358783 |
128 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.81191294 |
129 | * STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.81137230 |
130 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.80993363 |
131 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.80541832 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 4.66336291 |
2 | MP0005360_urolithiasis | 4.40466965 |
3 | MP0005365_abnormal_bile_salt | 3.74877690 |
4 | MP0009840_abnormal_foam_cell | 3.66658953 |
5 | MP0000569_abnormal_digit_pigmentation | 3.52850708 |
6 | MP0005085_abnormal_gallbladder_physiolo | 3.14725568 |
7 | MP0003191_abnormal_cellular_cholesterol | 2.89955527 |
8 | MP0003724_increased_susceptibility_to | 2.85560247 |
9 | MP0003252_abnormal_bile_duct | 2.64412317 |
10 | MP0008875_abnormal_xenobiotic_pharmacok | 2.58332569 |
11 | MP0010329_abnormal_lipoprotein_level | 2.48891858 |
12 | MP0005058_abnormal_lysosome_morphology | 2.26410550 |
13 | MP0002148_abnormal_hypersensitivity_rea | 2.25160547 |
14 | MP0003806_abnormal_nucleotide_metabolis | 2.09784433 |
15 | MP0001835_abnormal_antigen_presentation | 2.05156773 |
16 | MP0003303_peritoneal_inflammation | 1.99514828 |
17 | MP0003172_abnormal_lysosome_physiology | 1.99462001 |
18 | MP0003705_abnormal_hypodermis_morpholog | 1.98795056 |
19 | MP0000609_abnormal_liver_physiology | 1.98379160 |
20 | MP0003436_decreased_susceptibility_to | 1.93915002 |
21 | MP0003646_muscle_fatigue | 1.88386315 |
22 | MP0005076_abnormal_cell_differentiation | 1.84557704 |
23 | MP0005310_abnormal_salivary_gland | 1.79712882 |
24 | MP0009278_abnormal_bone_marrow | 1.78750345 |
25 | MP0001800_abnormal_humoral_immune | 1.77053068 |
26 | MP0003300_gastrointestinal_ulcer | 1.73517441 |
27 | MP0005083_abnormal_biliary_tract | 1.71864778 |
28 | MP0010307_abnormal_tumor_latency | 1.70735335 |
29 | MP0002998_abnormal_bone_remodeling | 1.67734804 |
30 | MP0001790_abnormal_immune_system | 1.67711021 |
31 | MP0005387_immune_system_phenotype | 1.67711021 |
32 | MP0002332_abnormal_exercise_endurance | 1.66084371 |
33 | MP0000685_abnormal_immune_system | 1.63975298 |
34 | MP0002166_altered_tumor_susceptibility | 1.49603360 |
35 | MP0010352_gastrointestinal_tract_polyps | 1.48562777 |
36 | MP0000015_abnormal_ear_pigmentation | 1.46760666 |
37 | MP0002118_abnormal_lipid_homeostasis | 1.46174675 |
38 | MP0002419_abnormal_innate_immunity | 1.45151505 |
39 | MP0005670_abnormal_white_adipose | 1.44560856 |
40 | MP0003950_abnormal_plasma_membrane | 1.40950700 |
41 | MP0005464_abnormal_platelet_physiology | 1.40208312 |
42 | MP0002452_abnormal_antigen_presenting | 1.38536124 |
43 | MP0004947_skin_inflammation | 1.37193295 |
44 | MP0005167_abnormal_blood-brain_barrier | 1.35643143 |
45 | MP0002138_abnormal_hepatobiliary_system | 1.35229046 |
46 | MP0005332_abnormal_amino_acid | 1.34062531 |
47 | MP0001666_abnormal_nutrient_absorption | 1.32554354 |
48 | MP0002723_abnormal_immune_serum | 1.29524514 |
49 | MP0002877_abnormal_melanocyte_morpholog | 1.29086657 |
50 | MP0004510_myositis | 1.26411585 |
51 | MP0004185_abnormal_adipocyte_glucose | 1.25130548 |
52 | MP0003763_abnormal_thymus_physiology | 1.23784612 |
53 | MP0000604_amyloidosis | 1.23044933 |
54 | MP0006054_spinal_hemorrhage | 1.22404700 |
55 | MP0005025_abnormal_response_to | 1.21570214 |
56 | MP0003566_abnormal_cell_adhesion | 1.20932581 |
57 | MP0003828_pulmonary_edema | 1.20420482 |
58 | MP0003656_abnormal_erythrocyte_physiolo | 1.20083359 |
59 | MP0002254_reproductive_system_inflammat | 1.19857019 |
60 | MP0005257_abnormal_intraocular_pressure | 1.18615677 |
61 | MP0000598_abnormal_liver_morphology | 1.16250460 |
62 | MP0008961_abnormal_basal_metabolism | 1.15662836 |
63 | MP0005000_abnormal_immune_tolerance | 1.14163061 |
64 | MP0005319_abnormal_enzyme/_coenzyme | 1.14072388 |
65 | MP0006082_CNS_inflammation | 1.14019675 |
66 | MP0004130_abnormal_muscle_cell | 1.11820927 |
67 | MP0009763_increased_sensitivity_to | 1.11221722 |
68 | MP0008057_abnormal_DNA_replication | 1.10369034 |
69 | MP0000343_altered_response_to | 1.09146914 |
70 | MP0000689_abnormal_spleen_morphology | 1.08042317 |
71 | MP0003183_abnormal_peptide_metabolism | 1.07676444 |
72 | MP0008469_abnormal_protein_level | 1.07316821 |
73 | MP0005666_abnormal_adipose_tissue | 1.06745183 |
74 | MP0001819_abnormal_immune_cell | 1.06550787 |
75 | MP0002420_abnormal_adaptive_immunity | 1.05914413 |
76 | MP0003329_amyloid_beta_deposits | 1.05859511 |
77 | MP0003075_altered_response_to | 1.05046207 |
78 | MP0008004_abnormal_stomach_pH | 1.04998839 |
79 | MP0002006_tumorigenesis | 1.03592251 |
80 | MP0003868_abnormal_feces_composition | 1.02461543 |
81 | MP0001845_abnormal_inflammatory_respons | 1.02031897 |
82 | MP0004019_abnormal_vitamin_homeostasis | 1.01735402 |
83 | MP0004264_abnormal_extraembryonic_tissu | 1.01591522 |
84 | MP0000716_abnormal_immune_system | 0.99967938 |
85 | MP0005397_hematopoietic_system_phenotyp | 0.99840148 |
86 | MP0001545_abnormal_hematopoietic_system | 0.99840148 |
87 | MP0002398_abnormal_bone_marrow | 0.99057267 |
88 | MP0001915_intracranial_hemorrhage | 0.96992226 |
89 | MP0009764_decreased_sensitivity_to | 0.96904733 |
90 | MP0009785_altered_susceptibility_to | 0.95281841 |
91 | MP0003195_calcinosis | 0.94906714 |
92 | MP0002971_abnormal_brown_adipose | 0.93724018 |
93 | MP0004808_abnormal_hematopoietic_stem | 0.92187891 |
94 | MP0009115_abnormal_fat_cell | 0.91819816 |
95 | MP0000371_diluted_coat_color | 0.91423351 |
96 | MP0002722_abnormal_immune_system | 0.89448245 |
97 | MP0002396_abnormal_hematopoietic_system | 0.89389153 |
98 | MP0003690_abnormal_glial_cell | 0.89002887 |
99 | MP0002405_respiratory_system_inflammati | 0.88771952 |
100 | MP0005671_abnormal_response_to | 0.87745814 |
101 | MP0009333_abnormal_splenocyte_physiolog | 0.85232545 |
102 | MP0003091_abnormal_cell_migration | 0.84644750 |
103 | MP0005451_abnormal_body_composition | 0.84466357 |
104 | MP0000920_abnormal_myelination | 0.84344538 |
105 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.83037492 |
106 | MP0010155_abnormal_intestine_physiology | 0.82769966 |
107 | MP0004233_abnormal_muscle_weight | 0.82755319 |
108 | MP0002429_abnormal_blood_cell | 0.82249047 |
109 | MP0000858_altered_metastatic_potential | 0.81993287 |
110 | MP0005164_abnormal_response_to | 0.81801186 |
111 | MP0003453_abnormal_keratinocyte_physiol | 0.81583533 |
112 | MP0003045_fibrosis | 0.80426453 |
113 | MP0009643_abnormal_urine_homeostasis | 0.79313560 |
114 | MP0005023_abnormal_wound_healing | 0.78635652 |
115 | MP0003279_aneurysm | 0.78585235 |
116 | MP0000249_abnormal_blood_vessel | 0.78051915 |
117 | MP0002933_joint_inflammation | 0.76879371 |
118 | MP0005409_darkened_coat_color | 0.75829871 |
119 | MP0002168_other_aberrant_phenotype | 0.75628815 |
120 | MP0001661_extended_life_span | 0.75159131 |
121 | MP0001851_eye_inflammation | 0.74626527 |
122 | MP0004381_abnormal_hair_follicle | 0.74490248 |
123 | MP0004883_abnormal_blood_vessel | 0.73987517 |
124 | MP0001853_heart_inflammation | 0.73654111 |
125 | MP0001873_stomach_inflammation | 0.73415568 |
126 | MP0008260_abnormal_autophagy | 0.72560993 |
127 | MP0001958_emphysema | 0.71501373 |
128 | MP0002136_abnormal_kidney_physiology | 0.71054805 |
129 | MP0001533_abnormal_skeleton_physiology | 0.70244312 |
130 | MP0001348_abnormal_lacrimal_gland | 0.70075765 |
131 | MP0005334_abnormal_fat_pad | 0.69924793 |
132 | MP0005174_abnormal_tail_pigmentation | 0.68408574 |
133 | MP0005647_abnormal_sex_gland | 0.67590840 |
134 | MP0003448_altered_tumor_morphology | 0.66599776 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormality of glycolipid metabolism (HP:0010969) | 6.38216830 |
2 | Abnormality of liposaccharide metabolism (HP:0010968) | 6.38216830 |
3 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 6.38216830 |
4 | Deep venous thrombosis (HP:0002625) | 4.68363004 |
5 | Intrahepatic cholestasis (HP:0001406) | 4.05546226 |
6 | Xanthomatosis (HP:0000991) | 4.04192186 |
7 | Vacuolated lymphocytes (HP:0001922) | 3.89267067 |
8 | Dysostosis multiplex (HP:0000943) | 3.87261393 |
9 | Myocardial infarction (HP:0001658) | 3.80448677 |
10 | Complement deficiency (HP:0004431) | 3.76639510 |
11 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 3.60647101 |
12 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.54566433 |
13 | Loss of speech (HP:0002371) | 3.43024152 |
14 | Hyperlipoproteinemia (HP:0010980) | 3.37917586 |
15 | Recurrent bacterial skin infections (HP:0005406) | 3.34545838 |
16 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 3.26442656 |
17 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 3.23759504 |
18 | Joint hemorrhage (HP:0005261) | 3.21282228 |
19 | Orchitis (HP:0100796) | 3.20027936 |
20 | Optic neuritis (HP:0100653) | 3.19905348 |
21 | Retrobulbar optic neuritis (HP:0100654) | 3.19905348 |
22 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 3.11216613 |
23 | Abnormality of polysaccharide metabolism (HP:0011012) | 3.11216613 |
24 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 3.11216613 |
25 | Abnormality of the fingertips (HP:0001211) | 3.09103393 |
26 | Prolonged partial thromboplastin time (HP:0003645) | 3.08698289 |
27 | Hypobetalipoproteinemia (HP:0003563) | 3.07917060 |
28 | Neurofibrillary tangles (HP:0002185) | 2.99259900 |
29 | Hypoalphalipoproteinemia (HP:0003233) | 2.98855361 |
30 | Abnormality of the common coagulation pathway (HP:0010990) | 2.98638612 |
31 | Mucopolysacchariduria (HP:0008155) | 2.97201149 |
32 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.97201149 |
33 | Epidermoid cyst (HP:0200040) | 2.90148327 |
34 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.88721874 |
35 | Hypolipoproteinemia (HP:0010981) | 2.83484240 |
36 | Mitral stenosis (HP:0001718) | 2.81946783 |
37 | Myositis (HP:0100614) | 2.78966307 |
38 | Hypercholesterolemia (HP:0003124) | 2.77836916 |
39 | Gingival bleeding (HP:0000225) | 2.77259630 |
40 | Recurrent abscess formation (HP:0002722) | 2.76573361 |
41 | Abnormality of complement system (HP:0005339) | 2.75707796 |
42 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 2.71729709 |
43 | Autoimmune thrombocytopenia (HP:0001973) | 2.71605706 |
44 | Disinhibition (HP:0000734) | 2.69805279 |
45 | Hematochezia (HP:0002573) | 2.64800672 |
46 | T lymphocytopenia (HP:0005403) | 2.63381868 |
47 | Hypochromic microcytic anemia (HP:0004840) | 2.61204179 |
48 | Interstitial pulmonary disease (HP:0006530) | 2.60086026 |
49 | Upper motor neuron abnormality (HP:0002127) | 2.56068776 |
50 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.55081102 |
51 | Systemic lupus erythematosus (HP:0002725) | 2.50629145 |
52 | Abnormality of T cell number (HP:0011839) | 2.48369987 |
53 | Mediastinal lymphadenopathy (HP:0100721) | 2.45993486 |
54 | Cerebral inclusion bodies (HP:0100314) | 2.42848053 |
55 | Hyperammonemia (HP:0001987) | 2.42480542 |
56 | Colitis (HP:0002583) | 2.42432982 |
57 | Periodontitis (HP:0000704) | 2.42238000 |
58 | Eczematoid dermatitis (HP:0000976) | 2.42022851 |
59 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 2.38541948 |
60 | Esophageal varix (HP:0002040) | 2.30228026 |
61 | Recurrent skin infections (HP:0001581) | 2.29082187 |
62 | Stomatitis (HP:0010280) | 2.26931207 |
63 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.23801980 |
64 | Hyperglycinemia (HP:0002154) | 2.23660843 |
65 | Recurrent fungal infections (HP:0002841) | 2.22816078 |
66 | Ketosis (HP:0001946) | 2.22285897 |
67 | Asymmetric septal hypertrophy (HP:0001670) | 2.19254566 |
68 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.19168112 |
69 | Recurrent cutaneous fungal infections (HP:0011370) | 2.19168112 |
70 | Increased cerebral lipofuscin (HP:0011813) | 2.19087694 |
71 | Glomerulonephritis (HP:0000099) | 2.18956948 |
72 | Thoracic kyphosis (HP:0002942) | 2.18370420 |
73 | Pulmonary infiltrates (HP:0002113) | 2.18080016 |
74 | Keratoconjunctivitis sicca (HP:0001097) | 2.16696692 |
75 | Abnormality of the periventricular white matter (HP:0002518) | 2.15839662 |
76 | Albinism (HP:0001022) | 2.14685442 |
77 | Ulnar bowing (HP:0003031) | 2.13482734 |
78 | Recurrent viral infections (HP:0004429) | 2.13254862 |
79 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.12817405 |
80 | Hepatocellular carcinoma (HP:0001402) | 2.12769352 |
81 | Spondylolisthesis (HP:0003302) | 2.11602490 |
82 | Spontaneous hematomas (HP:0007420) | 2.11081144 |
83 | Abnormality of glycine metabolism (HP:0010895) | 2.10157043 |
84 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.10157043 |
85 | Cerebral aneurysm (HP:0004944) | 2.10039518 |
86 | Spastic diplegia (HP:0001264) | 2.09006856 |
87 | Hyperglycinuria (HP:0003108) | 2.08304917 |
88 | Skin nodule (HP:0200036) | 2.07697844 |
89 | Hemorrhage of the eye (HP:0011885) | 2.07655720 |
90 | Fat malabsorption (HP:0002630) | 2.07059231 |
91 | Abnormality of iron homeostasis (HP:0011031) | 2.06157659 |
92 | Hypoglycemic coma (HP:0001325) | 2.05162851 |
93 | Gingivitis (HP:0000230) | 2.04986653 |
94 | Nephritis (HP:0000123) | 2.04841491 |
95 | Facial shape deformation (HP:0011334) | 2.04550836 |
96 | Potter facies (HP:0002009) | 2.04550836 |
97 | Heterotopia (HP:0002282) | 2.04402955 |
98 | Abnormality of methionine metabolism (HP:0010901) | 2.03558948 |
99 | Hemoptysis (HP:0002105) | 2.03020593 |
100 | Pseudobulbar signs (HP:0002200) | 1.99464207 |
101 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.97603766 |
102 | Keratoconjunctivitis (HP:0001096) | 1.97472528 |
103 | Global brain atrophy (HP:0002283) | 1.96162956 |
104 | Abnormality of the intrinsic pathway (HP:0010989) | 1.95953171 |
105 | Vasculitis (HP:0002633) | 1.95919668 |
106 | Inappropriate behavior (HP:0000719) | 1.95899916 |
107 | Abnormality of the thoracic spine (HP:0100711) | 1.95429087 |
108 | Thin bony cortex (HP:0002753) | 1.95175112 |
109 | Autoimmune hemolytic anemia (HP:0001890) | 1.94901413 |
110 | Subacute progressive viral hepatitis (HP:0006572) | 1.93168106 |
111 | Pustule (HP:0200039) | 1.92923821 |
112 | Conjugated hyperbilirubinemia (HP:0002908) | 1.92258972 |
113 | Amyloidosis (HP:0011034) | 1.91300404 |
114 | Abnormality of nucleobase metabolism (HP:0010932) | 1.89754162 |
115 | Abnormality of macrophages (HP:0004311) | 1.89461259 |
116 | Turricephaly (HP:0000262) | 1.85260723 |
117 | Coarse hair (HP:0002208) | 1.84823978 |
118 | Arterial thrombosis (HP:0004420) | 1.84668145 |
119 | Macroorchidism (HP:0000053) | 1.83948779 |
120 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.83864418 |
121 | Reticulocytosis (HP:0001923) | 1.83120764 |
122 | Hypoplasia of the thymus (HP:0000778) | 1.81376361 |
123 | Increased serum ferritin (HP:0003281) | 1.81366023 |
124 | Apathy (HP:0000741) | 1.81308435 |
125 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.80800044 |
126 | Neuronal loss in central nervous system (HP:0002529) | 1.79842063 |
127 | Prominent nose (HP:0000448) | 1.78850539 |
128 | Polycythemia (HP:0001901) | 1.77721056 |
129 | Dysmetric saccades (HP:0000641) | 1.76177181 |
130 | Abnormal enzyme/coenzyme activity (HP:0012379) | 1.76151726 |
131 | Mutism (HP:0002300) | 1.75699859 |
132 | Cellulitis (HP:0100658) | 1.74585484 |
133 | IgA deficiency (HP:0002720) | 1.74585416 |
134 | Persistence of primary teeth (HP:0006335) | 1.74507144 |
135 | Increased CSF protein (HP:0002922) | 1.73642734 |
136 | Aplasia/Hypoplasia involving the sinuses (HP:0009120) | 1.72263761 |
137 | Osteolytic defects of the hand bones (HP:0009699) | 1.71735856 |
138 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.71735856 |
139 | Axonal loss (HP:0003447) | 1.71579831 |
140 | Clumsiness (HP:0002312) | 1.70346869 |
141 | Progressive visual loss (HP:0000529) | 1.70197451 |
142 | Gastrointestinal infarctions (HP:0005244) | 1.70004498 |
143 | Restrictive lung disease (HP:0002091) | 1.69199413 |
144 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 1.69048264 |
145 | Ovoid vertebral bodies (HP:0003300) | 1.68775581 |
146 | Depressed nasal tip (HP:0000437) | 1.67872488 |
147 | Basal ganglia calcification (HP:0002135) | 1.67733109 |
148 | Absent frontal sinuses (HP:0002688) | 1.67668003 |
149 | Abnormality of the endocardium (HP:0004306) | 1.66672865 |
150 | Diminished motivation (HP:0000745) | 1.66529459 |
151 | Gastrointestinal inflammation (HP:0004386) | 1.66369130 |
152 | Increased mean platelet volume (HP:0011877) | 1.66317296 |
153 | Cardiomegaly (HP:0001640) | 1.66294062 |
154 | Abnormal platelet volume (HP:0011876) | 1.65022531 |
155 | Protuberant abdomen (HP:0001538) | 1.64546738 |
156 | Acanthocytosis (HP:0001927) | 1.64474289 |
157 | Conjunctival telangiectasia (HP:0000524) | 1.64453855 |
158 | Thrombophlebitis (HP:0004418) | 1.64191250 |
159 | Epistaxis (HP:0000421) | 1.64190591 |
160 | Increased IgE level (HP:0003212) | 1.64164008 |
161 | Peripheral demyelination (HP:0011096) | 1.63152972 |
162 | Aneurysm (HP:0002617) | 1.62913538 |
163 | Onion bulb formation (HP:0003383) | 1.61955869 |
164 | Flat acetabular roof (HP:0003180) | 1.61677492 |
165 | Frequent falls (HP:0002359) | 1.61598948 |
166 | Abnormality of alkaline phosphatase activity (HP:0004379) | 1.61513413 |
167 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.61330865 |
168 | Inflammation of the large intestine (HP:0002037) | 1.61177757 |
169 | Elevated alkaline phosphatase (HP:0003155) | 1.60961294 |
170 | Osteomyelitis (HP:0002754) | 1.60947953 |
171 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.58153575 |
Rank | Gene Set | Z-score |
---|---|---|
1 | CDK12 | 3.93617394 |
2 | TRIB3 | 3.09353528 |
3 | ERN1 | 2.84766744 |
4 | CAMK1D | 2.74115378 |
5 | TYK2 | 2.69904476 |
6 | MAP3K10 | 2.59698071 |
7 | MAP4K1 | 2.58094959 |
8 | SIK1 | 2.32410465 |
9 | CAMK1G | 2.30482588 |
10 | FGFR4 | 2.20368302 |
11 | TAOK3 | 2.07842372 |
12 | PRPF4B | 2.07759483 |
13 | JAK1 | 1.98859852 |
14 | EPHB1 | 1.80877363 |
15 | MAP3K14 | 1.77877419 |
16 | PTK6 | 1.77644534 |
17 | PKN2 | 1.75839856 |
18 | CDC42BPA | 1.74850107 |
19 | ACVR1B | 1.72910707 |
20 | TTN | 1.62421579 |
21 | CSF1R | 1.60209543 |
22 | BRD4 | 1.59037015 |
23 | LATS1 | 1.58232284 |
24 | MAP3K13 | 1.56548926 |
25 | GRK7 | 1.51308361 |
26 | ICK | 1.48905945 |
27 | DDR2 | 1.46722141 |
28 | TBK1 | 1.44786332 |
29 | KIT | 1.41595111 |
30 | CDK6 | 1.33978562 |
31 | JAK3 | 1.33497230 |
32 | RIPK1 | 1.33354395 |
33 | MTOR | 1.33249890 |
34 | GRK6 | 1.32136494 |
35 | CHUK | 1.26124466 |
36 | FRK | 1.25582843 |
37 | CSK | 1.24826738 |
38 | STK10 | 1.22886930 |
39 | NEK2 | 1.22777631 |
40 | SIK2 | 1.22696741 |
41 | EEF2K | 1.21835503 |
42 | IKBKE | 1.21155485 |
43 | FGR | 1.18893825 |
44 | MAP3K3 | 1.15961254 |
45 | IKBKB | 1.14822073 |
46 | HCK | 1.13050128 |
47 | SGK3 | 1.12574781 |
48 | MARK2 | 1.09319370 |
49 | FGFR3 | 1.06672130 |
50 | ZAP70 | 1.06330905 |
51 | STK4 | 1.05475260 |
52 | BCKDK | 1.02816010 |
53 | STK3 | 1.01481226 |
54 | MAPK11 | 1.00587394 |
55 | JAK2 | 1.00534617 |
56 | MAP2K3 | 0.99699703 |
57 | TGFBR2 | 0.99285507 |
58 | TAOK1 | 0.98463632 |
59 | IRAK1 | 0.97642758 |
60 | RIPK4 | 0.92674453 |
61 | TXK | 0.92057324 |
62 | PRKAA2 | 0.90384765 |
63 | AKT3 | 0.88327271 |
64 | MAP3K7 | 0.86127634 |
65 | FLT3 | 0.86071325 |
66 | TYRO3 | 0.84937244 |
67 | CAMKK2 | 0.83019743 |
68 | BLK | 0.81712871 |
69 | IRAK3 | 0.80260102 |
70 | PIM1 | 0.79635050 |
71 | CDK4 | 0.76497105 |
72 | ADRBK2 | 0.73437189 |
73 | TAOK2 | 0.72755330 |
74 | ERBB2 | 0.72489351 |
75 | INSRR | 0.72062486 |
76 | PRKAA1 | 0.71341050 |
77 | SGK2 | 0.71193431 |
78 | RPS6KA2 | 0.70988238 |
79 | MAP3K1 | 0.70862227 |
80 | SYK | 0.68163563 |
81 | BMX | 0.65801858 |
82 | HIPK2 | 0.65091584 |
83 | CDK9 | 0.64819251 |
84 | BTK | 0.63760209 |
85 | PDGFRB | 0.61454831 |
86 | NLK | 0.60964047 |
87 | PIK3CG | 0.60773383 |
88 | LCK | 0.59301591 |
89 | ALK | 0.57788770 |
90 | MAP3K11 | 0.56564216 |
91 | EGFR | 0.55664651 |
92 | MARK3 | 0.54901395 |
93 | FES | 0.54804937 |
94 | DYRK1B | 0.54788197 |
95 | CSNK1A1L | 0.54300646 |
96 | PRKD2 | 0.53906371 |
97 | ITK | 0.53157498 |
98 | PTK2 | 0.53040270 |
99 | WNK1 | 0.52956723 |
100 | STK38 | 0.52333863 |
101 | RPS6KA6 | 0.51839868 |
102 | RPS6KC1 | 0.51427319 |
103 | RPS6KL1 | 0.51427319 |
104 | PDK1 | 0.50403632 |
105 | PRKCH | 0.49071210 |
106 | NEK9 | 0.48389056 |
107 | ABL1 | 0.47145956 |
108 | IRAK4 | 0.46470843 |
109 | ERBB4 | 0.45707087 |
110 | LYN | 0.45697659 |
111 | EPHA3 | 0.45212240 |
112 | TNK2 | 0.45087855 |
113 | PDPK1 | 0.45027663 |
114 | RET | 0.44718646 |
115 | ATR | 0.44472909 |
116 | TRPM7 | 0.43848377 |
117 | PDGFRA | 0.43834606 |
118 | MELK | 0.43358312 |
119 | MAPK7 | 0.42529339 |
120 | PKN1 | 0.42219834 |
121 | CAMK4 | 0.41471851 |
122 | MAP3K6 | 0.39959083 |
123 | CSNK1D | 0.39884776 |
124 | MAPK1 | 0.38522791 |
125 | MATK | 0.36514618 |
126 | MAPK12 | 0.36260479 |
127 | FGFR2 | 0.35700572 |
128 | GSK3A | 0.34713098 |
129 | CHEK1 | 0.33360429 |
130 | RPS6KA4 | 0.32498747 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.30958507 |
2 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 3.28867872 |
3 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.11886376 |
4 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 2.90976941 |
5 | Other glycan degradation_Homo sapiens_hsa00511 | 2.67645070 |
6 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.55264330 |
7 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.46076850 |
8 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.45572553 |
9 | Lysine degradation_Homo sapiens_hsa00310 | 2.16407803 |
10 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.06346429 |
11 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.05176377 |
12 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.99601182 |
13 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.82167602 |
14 | ABC transporters_Homo sapiens_hsa02010 | 1.75806599 |
15 | Allograft rejection_Homo sapiens_hsa05330 | 1.72517304 |
16 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.67790247 |
17 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.66872742 |
18 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.65821558 |
19 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.62440826 |
20 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.61634989 |
21 | Asthma_Homo sapiens_hsa05310 | 1.56867235 |
22 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.53889159 |
23 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.50939904 |
24 | Malaria_Homo sapiens_hsa05144 | 1.50284476 |
25 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.49096492 |
26 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.48414028 |
27 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.45857775 |
28 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.44430407 |
29 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.35639546 |
30 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.31227585 |
31 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.29925195 |
32 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.28854659 |
33 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.26349765 |
34 | Peroxisome_Homo sapiens_hsa04146 | 1.26126478 |
35 | Pertussis_Homo sapiens_hsa05133 | 1.22168506 |
36 | Bile secretion_Homo sapiens_hsa04976 | 1.19482050 |
37 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.16314749 |
38 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.15623478 |
39 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.15538478 |
40 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.15329266 |
41 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.14760022 |
42 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.13573986 |
43 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.11412853 |
44 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.11218214 |
45 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.09948976 |
46 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.09279034 |
47 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.08957170 |
48 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.08453999 |
49 | Insulin resistance_Homo sapiens_hsa04931 | 1.06108667 |
50 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.05225056 |
51 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.04709089 |
52 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.04634331 |
53 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.04397537 |
54 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.03718081 |
55 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.03688008 |
56 | Retinol metabolism_Homo sapiens_hsa00830 | 1.02661392 |
57 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.02315332 |
58 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.02218203 |
59 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.01783375 |
60 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.00888847 |
61 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.98556826 |
62 | Histidine metabolism_Homo sapiens_hsa00340 | 0.96027021 |
63 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.94110896 |
64 | Phagosome_Homo sapiens_hsa04145 | 0.93636750 |
65 | Leishmaniasis_Homo sapiens_hsa05140 | 0.93595710 |
66 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.92858818 |
67 | Viral myocarditis_Homo sapiens_hsa05416 | 0.92180216 |
68 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.90226778 |
69 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.89939602 |
70 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.88598215 |
71 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.87997804 |
72 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.87033931 |
73 | Measles_Homo sapiens_hsa05162 | 0.85519388 |
74 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.84922347 |
75 | Legionellosis_Homo sapiens_hsa05134 | 0.83639993 |
76 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.82834467 |
77 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.82712607 |
78 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.82540421 |
79 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.82381195 |
80 | Amoebiasis_Homo sapiens_hsa05146 | 0.82211668 |
81 | Platelet activation_Homo sapiens_hsa04611 | 0.82114868 |
82 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.81943230 |
83 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.78801623 |
84 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.78146748 |
85 | Influenza A_Homo sapiens_hsa05164 | 0.76609957 |
86 | Bladder cancer_Homo sapiens_hsa05219 | 0.75371863 |
87 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.75115637 |
88 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.74199803 |
89 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.73158254 |
90 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.72855636 |
91 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.72461584 |
92 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.72270837 |
93 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.70753570 |
94 | Lysosome_Homo sapiens_hsa04142 | 0.70648585 |
95 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.68423884 |
96 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.67971636 |
97 | Carbon metabolism_Homo sapiens_hsa01200 | 0.67937015 |
98 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.67644332 |
99 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.67086721 |
100 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.65271331 |
101 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.65051556 |
102 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.64732784 |
103 | Salmonella infection_Homo sapiens_hsa05132 | 0.64636931 |
104 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.62544500 |
105 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.61302027 |
106 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.60699992 |
107 | Prostate cancer_Homo sapiens_hsa05215 | 0.60621020 |
108 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.60273038 |
109 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.60179753 |
110 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.59689668 |
111 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.59284431 |
112 | Endometrial cancer_Homo sapiens_hsa05213 | 0.58805401 |
113 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.58585536 |
114 | Hepatitis C_Homo sapiens_hsa05160 | 0.57866596 |
115 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.57406386 |
116 | Tuberculosis_Homo sapiens_hsa05152 | 0.57268567 |
117 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.56371593 |
118 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.56358093 |
119 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.55972311 |
120 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.55743123 |
121 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.55342607 |
122 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.55035831 |
123 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.53425978 |
124 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.52407154 |
125 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.52042036 |
126 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.51915507 |
127 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.50134269 |
128 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.49678334 |
129 | Focal adhesion_Homo sapiens_hsa04510 | 0.49462831 |
130 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.49102150 |
131 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.48975847 |
132 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.48746171 |
133 | Apoptosis_Homo sapiens_hsa04210 | 0.48282159 |
134 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.46856984 |
135 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.46831572 |
136 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.46492591 |
137 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.46222461 |
138 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.45244887 |
139 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.43854297 |
140 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.43548076 |
141 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.43205999 |
142 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.42997728 |
143 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.42123538 |
144 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.39211361 |
145 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.38801873 |
146 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.36111126 |
147 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.34944092 |
148 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.34760630 |
149 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.34575252 |
150 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.34506961 |
151 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.34369505 |
152 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.33841608 |
153 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.33129346 |
154 | Hepatitis B_Homo sapiens_hsa05161 | 0.32396934 |
155 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.31542764 |