ZFYVE26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phospholipid homeostasis (GO:0055091)4.97511830
2urea cycle (GO:0000050)4.25477761
3urea metabolic process (GO:0019627)4.25477761
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.20676741
5L-phenylalanine catabolic process (GO:0006559)4.20676741
6alpha-linolenic acid metabolic process (GO:0036109)3.98023923
7aromatic amino acid family catabolic process (GO:0009074)3.97080588
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.96832580
9negative regulation of interleukin-12 production (GO:0032695)3.95706504
10fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.92770479
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.91782985
12L-phenylalanine metabolic process (GO:0006558)3.91782985
13regulation of cholesterol homeostasis (GO:2000188)3.82199637
14indole-containing compound catabolic process (GO:0042436)3.80014387
15indolalkylamine catabolic process (GO:0046218)3.80014387
16tryptophan catabolic process (GO:0006569)3.80014387
17kynurenine metabolic process (GO:0070189)3.78778683
18phospholipid efflux (GO:0033700)3.76700863
19tryptophan metabolic process (GO:0006568)3.74722719
20nitrogen cycle metabolic process (GO:0071941)3.73192153
21cellular response to ethanol (GO:0071361)3.72212218
22complement activation, alternative pathway (GO:0006957)3.67493454
23dicarboxylic acid biosynthetic process (GO:0043650)3.62919972
24high-density lipoprotein particle remodeling (GO:0034375)3.60847995
25negative regulation of fibrinolysis (GO:0051918)3.60632028
26response to type I interferon (GO:0034340)3.55276835
27type I interferon signaling pathway (GO:0060337)3.52278721
28cellular response to type I interferon (GO:0071357)3.52278721
29peptidyl-glutamic acid carboxylation (GO:0017187)3.50870369
30protein carboxylation (GO:0018214)3.50870369
31regulation of protein activation cascade (GO:2000257)3.50368502
32macrophage activation involved in immune response (GO:0002281)3.48902865
33positive regulation of gamma-delta T cell activation (GO:0046645)3.43768195
34positive regulation of fatty acid beta-oxidation (GO:0032000)3.42985737
35regulation of cholesterol storage (GO:0010885)3.41041106
36plasma lipoprotein particle clearance (GO:0034381)3.40694608
37reverse cholesterol transport (GO:0043691)3.38294551
38plasma lipoprotein particle assembly (GO:0034377)3.37501553
39glycosphingolipid catabolic process (GO:0046479)3.34989555
40cholesterol efflux (GO:0033344)3.34566943
41regulation of interferon-beta biosynthetic process (GO:0045357)3.32254544
42protein-lipid complex assembly (GO:0065005)3.30312023
43response to peptidoglycan (GO:0032494)3.29627037
44bile acid biosynthetic process (GO:0006699)3.28920057
45macroautophagy (GO:0016236)3.28619220
46regulation of complement activation (GO:0030449)3.28141361
47serine family amino acid catabolic process (GO:0009071)3.27055689
48negative regulation of cholesterol transport (GO:0032375)3.26507979
49negative regulation of sterol transport (GO:0032372)3.26507979
50protein-lipid complex remodeling (GO:0034368)3.25447288
51macromolecular complex remodeling (GO:0034367)3.25447288
52plasma lipoprotein particle remodeling (GO:0034369)3.25447288
53cysteine metabolic process (GO:0006534)3.24306084
54regulation of cholesterol esterification (GO:0010872)3.21995200
55low-density lipoprotein particle remodeling (GO:0034374)3.16818735
56regulation of fatty acid beta-oxidation (GO:0031998)3.16365829
57regulation of triglyceride catabolic process (GO:0010896)3.14396345
58glyoxylate metabolic process (GO:0046487)3.13912557
59positive regulation of lipid catabolic process (GO:0050996)3.13877405
60oligosaccharide catabolic process (GO:0009313)3.13760029
61bile acid metabolic process (GO:0008206)3.12813141
62regulation of fibrinolysis (GO:0051917)3.12248722
63homocysteine metabolic process (GO:0050667)3.12005752
64germinal center formation (GO:0002467)3.11477825
65sulfur amino acid catabolic process (GO:0000098)3.10203084
66regulation of gamma-delta T cell differentiation (GO:0045586)3.08999004
67positive regulation of cholesterol transport (GO:0032376)3.01093672
68positive regulation of sterol transport (GO:0032373)3.01093672
69amino-acid betaine metabolic process (GO:0006577)3.00260809
70low-density lipoprotein particle clearance (GO:0034383)2.98355216
71glycolipid catabolic process (GO:0019377)2.96489145
72plasma lipoprotein particle organization (GO:0071827)2.94497278
73regulation of T-helper 1 cell differentiation (GO:0045625)2.94378451
74positive regulation of cholesterol efflux (GO:0010875)2.93282190
75protein-lipid complex subunit organization (GO:0071825)2.93097181
76negative regulation of cell killing (GO:0031342)2.93012685
77negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93012685
78regulation of gamma-delta T cell activation (GO:0046643)2.91388122
79modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.90303354
80positive regulation by organism of defense response of other organism involved in symbiotic interact2.90303354
81modulation by symbiont of host immune response (GO:0052553)2.90303354
82positive regulation by symbiont of host defense response (GO:0052509)2.90303354
83modulation by symbiont of host defense response (GO:0052031)2.90303354
84detection of molecule of bacterial origin (GO:0032490)2.88628161
85regulation of type I interferon-mediated signaling pathway (GO:0060338)2.87801901
86positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.86359710
87lipoprotein metabolic process (GO:0042157)2.85956640
88valine metabolic process (GO:0006573)2.83746549
89tyrosine metabolic process (GO:0006570)2.83378408
90cholesterol homeostasis (GO:0042632)2.82758007
91regulation of vitamin D biosynthetic process (GO:0060556)2.81708285
92positive regulation of interferon-alpha production (GO:0032727)2.81288542
93mannose metabolic process (GO:0006013)2.80496933
94negative regulation of lipid transport (GO:0032369)2.80271561
95interferon-gamma-mediated signaling pathway (GO:0060333)2.80126722
96sterol homeostasis (GO:0055092)2.79759750
97response to muramyl dipeptide (GO:0032495)2.79365026
98lipopolysaccharide-mediated signaling pathway (GO:0031663)2.79133013
99aromatic amino acid family metabolic process (GO:0009072)2.78884999
100antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78485953
101antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78485953
102glycine metabolic process (GO:0006544)2.76195738
103lysine metabolic process (GO:0006553)2.74153370
104lysine catabolic process (GO:0006554)2.74153370
105very-low-density lipoprotein particle assembly (GO:0034379)2.73973337
106triglyceride homeostasis (GO:0070328)2.73093844
107acylglycerol homeostasis (GO:0055090)2.73093844
108regulation of dendritic cell antigen processing and presentation (GO:0002604)2.72608336
109N-acetylneuraminate metabolic process (GO:0006054)2.72459255
110negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.71421183
111cellular response to exogenous dsRNA (GO:0071360)2.70449670
112detection of other organism (GO:0098543)2.70256194
113regulation of protein polyubiquitination (GO:1902914)2.70148630
114regulation of sterol transport (GO:0032371)2.65364901
115regulation of cholesterol transport (GO:0032374)2.65364901
116indolalkylamine metabolic process (GO:0006586)2.64975613
117regulation of membrane protein ectodomain proteolysis (GO:0051043)2.64128279
118cellular response to thyroid hormone stimulus (GO:0097067)2.64051700
119regulation of interferon-alpha production (GO:0032647)2.63954815
120regulation of interleukin-12 biosynthetic process (GO:0045075)2.63937220
121antigen processing and presentation of endogenous antigen (GO:0019883)2.63615000
122negative regulation of cytokine production involved in immune response (GO:0002719)2.63576778
123negative regulation of lipid storage (GO:0010888)2.63215684
124ceramide catabolic process (GO:0046514)2.63122160
125alpha-amino acid catabolic process (GO:1901606)2.62795871
126positive regulation of histone deacetylation (GO:0031065)2.62386286
127myeloid dendritic cell differentiation (GO:0043011)2.59757497
128complement activation, classical pathway (GO:0006958)2.59421953
129ethanol oxidation (GO:0006069)2.58744206
130bile acid and bile salt transport (GO:0015721)2.58547232
131cytoplasmic mRNA processing body assembly (GO:0033962)2.57812125
132antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.57048821
133negative regulation of fatty acid biosynthetic process (GO:0045717)2.56771384
134negative regulation of lipase activity (GO:0060192)2.56034938
135lipoprotein transport (GO:0042953)2.56030186
136amino sugar catabolic process (GO:0046348)2.55214229
137modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.55088530
138regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.54397875
139regulation of MHC class I biosynthetic process (GO:0045343)2.53912179
140iron ion import (GO:0097286)2.53583251
141positive regulation of antigen processing and presentation (GO:0002579)2.52495108
142detection of external biotic stimulus (GO:0098581)2.51195727
143positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.50847456
144regulation of cytokine secretion involved in immune response (GO:0002739)2.50197843
145positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.49624597
146NIK/NF-kappaB signaling (GO:0038061)2.48991100
147T-helper 1 type immune response (GO:0042088)2.48466111
148regulation of antigen processing and presentation (GO:0002577)2.47671771
149cellular extravasation (GO:0045123)2.47367942
150JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.47097277
151immunoglobulin mediated immune response (GO:0016064)2.46213794
152regulation of interleukin-12 production (GO:0032655)2.42119090
153protein localization to endosome (GO:0036010)2.42095337
154positive regulation of interferon-beta production (GO:0032728)2.41416796
155detection of bacterium (GO:0016045)2.40546895
156positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.38442075
157histone H3-K36 demethylation (GO:0070544)2.36446939
158positive regulation of type 2 immune response (GO:0002830)2.35259394
159positive regulation of cellular amide metabolic process (GO:0034250)2.35170271
160regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.34370975
161regulation of T cell tolerance induction (GO:0002664)2.34267817
162defense response to protozoan (GO:0042832)2.34251272
163positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.33906450
164regulation of interferon-beta production (GO:0032648)2.33863125
165regulation of necroptotic process (GO:0060544)2.33403360
166response to protozoan (GO:0001562)2.32468374
167macrophage activation (GO:0042116)2.31203604
168negative regulation of nitric oxide biosynthetic process (GO:0045019)2.29092034
169pinocytosis (GO:0006907)2.28936144
170cellular response to interferon-alpha (GO:0035457)2.24143655
171positive regulation of heat generation (GO:0031652)2.22924642
172detection of biotic stimulus (GO:0009595)2.22416363
173positive regulation of leukocyte degranulation (GO:0043302)2.20421118
174negative regulation of T cell mediated immunity (GO:0002710)2.20417006
175positive regulation of natural killer cell activation (GO:0032816)2.19907296
176regulation of mononuclear cell migration (GO:0071675)2.19583914
177regulation of response to interferon-gamma (GO:0060330)2.19508763
178myeloid dendritic cell activation (GO:0001773)2.18499179
179negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.17475794
180neutrophil activation involved in immune response (GO:0002283)2.16866160
181regulation of type 2 immune response (GO:0002828)2.16151493
182response to lipoprotein particle (GO:0055094)2.15833796

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.91911054
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.44794118
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.11611211
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.83434692
5* IRF8_22096565_ChIP-ChIP_GC-B_Human3.81349201
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.17789718
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.97082671
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.77659022
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.67971508
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.63120143
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.51622926
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39193196
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.38690075
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37865032
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.35199438
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25425494
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.20903653
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.19204924
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.17602599
20* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.16698440
21GATA1_22025678_ChIP-Seq_K562_Human2.14927477
22MYC_22102868_ChIP-Seq_BL_Human2.07944282
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06192174
24* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.90915986
25E2F7_22180533_ChIP-Seq_HELA_Human1.83177546
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81213964
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79971649
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79874227
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.79475118
30* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78012978
31VDR_21846776_ChIP-Seq_THP-1_Human1.71537497
32TCF7_22412390_ChIP-Seq_EML_Mouse1.71519714
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.68948719
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.67035957
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63718368
36* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63650865
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.61762196
38MAF_26560356_Chip-Seq_TH1_Human1.58370831
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57769226
40SCL_19346495_ChIP-Seq_HPC-7_Human1.51119243
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50897252
42MYB_26560356_Chip-Seq_TH1_Human1.49727880
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.49509609
44SPI1_23127762_ChIP-Seq_K562_Human1.48479387
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48174565
46KDM2B_26808549_Chip-Seq_DND41_Human1.48120971
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46574821
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46307178
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.44150475
50CLOCK_20551151_ChIP-Seq_293T_Human1.42462508
51RUNX_20019798_ChIP-Seq_JUKART_Human1.40156180
52TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.39993785
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39708975
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35967270
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34037410
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31132922
57UTX_26944678_Chip-Seq_JUKART_Human1.27757285
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26271407
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24390344
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24123142
61PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24092148
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.23195249
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.23148577
64TP53_16413492_ChIP-PET_HCT116_Human1.22721455
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.22713364
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22308432
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.21457468
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.20949327
69GATA1_19941826_ChIP-Seq_K562_Human1.19974175
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19598961
71MYB_26560356_Chip-Seq_TH2_Human1.19241219
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.18410329
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17243403
74VDR_24763502_ChIP-Seq_THP-1_Human1.15055443
75AHR_22903824_ChIP-Seq_MCF-7_Human1.14485650
76ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12946826
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12547403
78PU_27001747_Chip-Seq_BMDM_Mouse1.11567911
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11324851
80SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10183415
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09985010
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09598230
83* HNF4A_19822575_ChIP-Seq_HepG2_Human1.08182889
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07235823
85TP63_17297297_ChIP-ChIP_HaCaT_Human1.07128118
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05843873
87GATA6_25053715_ChIP-Seq_YYC3_Human1.04852414
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04289336
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.01055224
90FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00324478
91SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99938918
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99938918
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99180801
94ESR1_21235772_ChIP-Seq_MCF-7_Human0.97900239
95NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96525542
96NCOR1_26117541_ChIP-Seq_K562_Human0.95461596
97CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94620672
98SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94039835
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92880723
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92547647
101ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92443528
102GATA3_27048872_Chip-Seq_THYMUS_Human0.92100990
103GATA2_19941826_ChIP-Seq_K562_Human0.91133060
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90461332
105GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90251938
106GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90171712
107P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90068835
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89771571
109KDM2B_26808549_Chip-Seq_K562_Human0.88713620
110CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88053783
111LXR_22292898_ChIP-Seq_THP-1_Human0.88045696
112CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87596816
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87473226
114MAF_26560356_Chip-Seq_TH2_Human0.87359228
115* SPI1_23547873_ChIP-Seq_NB4_Human0.86025858
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85811844
117PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84784804
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.84188288
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.84188288
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.84148171
121GATA2_21666600_ChIP-Seq_HMVEC_Human0.83762947
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82765724
123VDR_24787735_ChIP-Seq_THP-1_Human0.82496275
124KDM2B_26808549_Chip-Seq_JURKAT_Human0.82277799
125NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81689672
126* TFEB_21752829_ChIP-Seq_HELA_Human0.81467701
127RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81358783
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81191294
129* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81137230
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80993363
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80541832

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.66336291
2MP0005360_urolithiasis4.40466965
3MP0005365_abnormal_bile_salt3.74877690
4MP0009840_abnormal_foam_cell3.66658953
5MP0000569_abnormal_digit_pigmentation3.52850708
6MP0005085_abnormal_gallbladder_physiolo3.14725568
7MP0003191_abnormal_cellular_cholesterol2.89955527
8MP0003724_increased_susceptibility_to2.85560247
9MP0003252_abnormal_bile_duct2.64412317
10MP0008875_abnormal_xenobiotic_pharmacok2.58332569
11MP0010329_abnormal_lipoprotein_level2.48891858
12MP0005058_abnormal_lysosome_morphology2.26410550
13MP0002148_abnormal_hypersensitivity_rea2.25160547
14MP0003806_abnormal_nucleotide_metabolis2.09784433
15MP0001835_abnormal_antigen_presentation2.05156773
16MP0003303_peritoneal_inflammation1.99514828
17MP0003172_abnormal_lysosome_physiology1.99462001
18MP0003705_abnormal_hypodermis_morpholog1.98795056
19MP0000609_abnormal_liver_physiology1.98379160
20MP0003436_decreased_susceptibility_to1.93915002
21MP0003646_muscle_fatigue1.88386315
22MP0005076_abnormal_cell_differentiation1.84557704
23MP0005310_abnormal_salivary_gland1.79712882
24MP0009278_abnormal_bone_marrow1.78750345
25MP0001800_abnormal_humoral_immune1.77053068
26MP0003300_gastrointestinal_ulcer1.73517441
27MP0005083_abnormal_biliary_tract1.71864778
28MP0010307_abnormal_tumor_latency1.70735335
29MP0002998_abnormal_bone_remodeling1.67734804
30MP0005387_immune_system_phenotype1.67711021
31MP0001790_abnormal_immune_system1.67711021
32MP0002332_abnormal_exercise_endurance1.66084371
33MP0000685_abnormal_immune_system1.63975298
34MP0002166_altered_tumor_susceptibility1.49603360
35MP0010352_gastrointestinal_tract_polyps1.48562777
36MP0000015_abnormal_ear_pigmentation1.46760666
37MP0002118_abnormal_lipid_homeostasis1.46174675
38MP0002419_abnormal_innate_immunity1.45151505
39MP0005670_abnormal_white_adipose1.44560856
40MP0003950_abnormal_plasma_membrane1.40950700
41MP0005464_abnormal_platelet_physiology1.40208312
42MP0002452_abnormal_antigen_presenting1.38536124
43MP0004947_skin_inflammation1.37193295
44MP0005167_abnormal_blood-brain_barrier1.35643143
45MP0002138_abnormal_hepatobiliary_system1.35229046
46MP0005332_abnormal_amino_acid1.34062531
47MP0001666_abnormal_nutrient_absorption1.32554354
48MP0002723_abnormal_immune_serum1.29524514
49MP0002877_abnormal_melanocyte_morpholog1.29086657
50MP0004510_myositis1.26411585
51MP0004185_abnormal_adipocyte_glucose1.25130548
52MP0003763_abnormal_thymus_physiology1.23784612
53MP0000604_amyloidosis1.23044933
54MP0006054_spinal_hemorrhage1.22404700
55MP0005025_abnormal_response_to1.21570214
56MP0003566_abnormal_cell_adhesion1.20932581
57MP0003828_pulmonary_edema1.20420482
58MP0003656_abnormal_erythrocyte_physiolo1.20083359
59MP0002254_reproductive_system_inflammat1.19857019
60MP0005257_abnormal_intraocular_pressure1.18615677
61MP0000598_abnormal_liver_morphology1.16250460
62MP0008961_abnormal_basal_metabolism1.15662836
63MP0005000_abnormal_immune_tolerance1.14163061
64MP0005319_abnormal_enzyme/_coenzyme1.14072388
65MP0006082_CNS_inflammation1.14019675
66MP0004130_abnormal_muscle_cell1.11820927
67MP0009763_increased_sensitivity_to1.11221722
68MP0008057_abnormal_DNA_replication1.10369034
69MP0000343_altered_response_to1.09146914
70MP0000689_abnormal_spleen_morphology1.08042317
71MP0003183_abnormal_peptide_metabolism1.07676444
72MP0008469_abnormal_protein_level1.07316821
73MP0005666_abnormal_adipose_tissue1.06745183
74MP0001819_abnormal_immune_cell1.06550787
75MP0002420_abnormal_adaptive_immunity1.05914413
76MP0003329_amyloid_beta_deposits1.05859511
77MP0003075_altered_response_to1.05046207
78MP0008004_abnormal_stomach_pH1.04998839
79MP0002006_tumorigenesis1.03592251
80MP0003868_abnormal_feces_composition1.02461543
81MP0001845_abnormal_inflammatory_respons1.02031897
82MP0004019_abnormal_vitamin_homeostasis1.01735402
83MP0004264_abnormal_extraembryonic_tissu1.01591522
84MP0000716_abnormal_immune_system0.99967938
85MP0005397_hematopoietic_system_phenotyp0.99840148
86MP0001545_abnormal_hematopoietic_system0.99840148
87MP0002398_abnormal_bone_marrow0.99057267
88MP0001915_intracranial_hemorrhage0.96992226
89MP0009764_decreased_sensitivity_to0.96904733
90MP0009785_altered_susceptibility_to0.95281841
91MP0003195_calcinosis0.94906714
92MP0002971_abnormal_brown_adipose0.93724018
93MP0004808_abnormal_hematopoietic_stem0.92187891
94MP0009115_abnormal_fat_cell0.91819816
95MP0000371_diluted_coat_color0.91423351
96MP0002722_abnormal_immune_system0.89448245
97MP0002396_abnormal_hematopoietic_system0.89389153
98MP0003690_abnormal_glial_cell0.89002887
99MP0002405_respiratory_system_inflammati0.88771952
100MP0005671_abnormal_response_to0.87745814
101MP0009333_abnormal_splenocyte_physiolog0.85232545
102MP0003091_abnormal_cell_migration0.84644750
103MP0005451_abnormal_body_composition0.84466357
104MP0000920_abnormal_myelination0.84344538
105MP0005584_abnormal_enzyme/coenzyme_acti0.83037492
106MP0010155_abnormal_intestine_physiology0.82769966
107MP0004233_abnormal_muscle_weight0.82755319
108MP0002429_abnormal_blood_cell0.82249047
109MP0000858_altered_metastatic_potential0.81993287
110MP0005164_abnormal_response_to0.81801186
111MP0003453_abnormal_keratinocyte_physiol0.81583533
112MP0003045_fibrosis0.80426453
113MP0009643_abnormal_urine_homeostasis0.79313560
114MP0005023_abnormal_wound_healing0.78635652
115MP0003279_aneurysm0.78585235
116MP0000249_abnormal_blood_vessel0.78051915
117MP0002933_joint_inflammation0.76879371
118MP0005409_darkened_coat_color0.75829871
119MP0002168_other_aberrant_phenotype0.75628815
120MP0001661_extended_life_span0.75159131
121MP0001851_eye_inflammation0.74626527
122MP0004381_abnormal_hair_follicle0.74490248
123MP0004883_abnormal_blood_vessel0.73987517
124MP0001853_heart_inflammation0.73654111
125MP0001873_stomach_inflammation0.73415568
126MP0008260_abnormal_autophagy0.72560993
127MP0001958_emphysema0.71501373
128MP0002136_abnormal_kidney_physiology0.71054805
129MP0001533_abnormal_skeleton_physiology0.70244312
130MP0001348_abnormal_lacrimal_gland0.70075765
131MP0005334_abnormal_fat_pad0.69924793
132MP0005174_abnormal_tail_pigmentation0.68408574
133MP0005647_abnormal_sex_gland0.67590840
134MP0003448_altered_tumor_morphology0.66599776

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)6.38216830
2Abnormality of glycosphingolipid metabolism (HP:0004343)6.38216830
3Abnormality of glycolipid metabolism (HP:0010969)6.38216830
4Deep venous thrombosis (HP:0002625)4.68363004
5Intrahepatic cholestasis (HP:0001406)4.05546226
6Xanthomatosis (HP:0000991)4.04192186
7Vacuolated lymphocytes (HP:0001922)3.89267067
8Dysostosis multiplex (HP:0000943)3.87261393
9Myocardial infarction (HP:0001658)3.80448677
10Complement deficiency (HP:0004431)3.76639510
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.60647101
12Recurrent gram-negative bacterial infections (HP:0005420)3.54566433
13Loss of speech (HP:0002371)3.43024152
14Hyperlipoproteinemia (HP:0010980)3.37917586
15Recurrent bacterial skin infections (HP:0005406)3.34545838
16Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.26442656
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.23759504
18Joint hemorrhage (HP:0005261)3.21282228
19Orchitis (HP:0100796)3.20027936
20Retrobulbar optic neuritis (HP:0100654)3.19905348
21Optic neuritis (HP:0100653)3.19905348
22Abnormality of polysaccharide metabolism (HP:0011012)3.11216613
23Abnormality of glycosaminoglycan metabolism (HP:0004371)3.11216613
24Abnormality of mucopolysaccharide metabolism (HP:0011020)3.11216613
25Abnormality of the fingertips (HP:0001211)3.09103393
26Prolonged partial thromboplastin time (HP:0003645)3.08698289
27Hypobetalipoproteinemia (HP:0003563)3.07917060
28Neurofibrillary tangles (HP:0002185)2.99259900
29Hypoalphalipoproteinemia (HP:0003233)2.98855361
30Abnormality of the common coagulation pathway (HP:0010990)2.98638612
31Mucopolysacchariduria (HP:0008155)2.97201149
32Urinary glycosaminoglycan excretion (HP:0003541)2.97201149
33Epidermoid cyst (HP:0200040)2.90148327
34Abnormality of sulfur amino acid metabolism (HP:0004339)2.88721874
35Hypolipoproteinemia (HP:0010981)2.83484240
36Mitral stenosis (HP:0001718)2.81946783
37Myositis (HP:0100614)2.78966307
38Hypercholesterolemia (HP:0003124)2.77836916
39Gingival bleeding (HP:0000225)2.77259630
40Recurrent abscess formation (HP:0002722)2.76573361
41Abnormality of complement system (HP:0005339)2.75707796
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.71729709
43Autoimmune thrombocytopenia (HP:0001973)2.71605706
44Disinhibition (HP:0000734)2.69805279
45Hematochezia (HP:0002573)2.64800672
46T lymphocytopenia (HP:0005403)2.63381868
47Hypochromic microcytic anemia (HP:0004840)2.61204179
48Interstitial pulmonary disease (HP:0006530)2.60086026
49Upper motor neuron abnormality (HP:0002127)2.56068776
50Abnormality of pyrimidine metabolism (HP:0004353)2.55081102
51Systemic lupus erythematosus (HP:0002725)2.50629145
52Abnormality of T cell number (HP:0011839)2.48369987
53Mediastinal lymphadenopathy (HP:0100721)2.45993486
54Cerebral inclusion bodies (HP:0100314)2.42848053
55Hyperammonemia (HP:0001987)2.42480542
56Colitis (HP:0002583)2.42432982
57Periodontitis (HP:0000704)2.42238000
58Eczematoid dermatitis (HP:0000976)2.42022851
59Abnormality of glutamine family amino acid metabolism (HP:0010902)2.38541948
60Esophageal varix (HP:0002040)2.30228026
61Recurrent skin infections (HP:0001581)2.29082187
62Stomatitis (HP:0010280)2.26931207
63Abnormality of the vasculature of the conjunctiva (HP:0008054)2.23801980
64Hyperglycinemia (HP:0002154)2.23660843
65Recurrent fungal infections (HP:0002841)2.22816078
66Ketosis (HP:0001946)2.22285897
67Asymmetric septal hypertrophy (HP:0001670)2.19254566
68Recurrent cutaneous fungal infections (HP:0011370)2.19168112
69Chronic mucocutaneous candidiasis (HP:0002728)2.19168112
70Increased cerebral lipofuscin (HP:0011813)2.19087694
71Glomerulonephritis (HP:0000099)2.18956948
72Thoracic kyphosis (HP:0002942)2.18370420
73Pulmonary infiltrates (HP:0002113)2.18080016
74Keratoconjunctivitis sicca (HP:0001097)2.16696692
75Abnormality of the periventricular white matter (HP:0002518)2.15839662
76Albinism (HP:0001022)2.14685442
77Ulnar bowing (HP:0003031)2.13482734
78Recurrent viral infections (HP:0004429)2.13254862
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.12817405
80Hepatocellular carcinoma (HP:0001402)2.12769352
81Spondylolisthesis (HP:0003302)2.11602490
82Spontaneous hematomas (HP:0007420)2.11081144
83Abnormality of serine family amino acid metabolism (HP:0010894)2.10157043
84Abnormality of glycine metabolism (HP:0010895)2.10157043
85Cerebral aneurysm (HP:0004944)2.10039518
86Spastic diplegia (HP:0001264)2.09006856
87Hyperglycinuria (HP:0003108)2.08304917
88Skin nodule (HP:0200036)2.07697844
89Hemorrhage of the eye (HP:0011885)2.07655720
90Fat malabsorption (HP:0002630)2.07059231
91Abnormality of iron homeostasis (HP:0011031)2.06157659
92Hypoglycemic coma (HP:0001325)2.05162851
93Gingivitis (HP:0000230)2.04986653
94Nephritis (HP:0000123)2.04841491
95Potter facies (HP:0002009)2.04550836
96Facial shape deformation (HP:0011334)2.04550836
97Heterotopia (HP:0002282)2.04402955
98Abnormality of methionine metabolism (HP:0010901)2.03558948
99Hemoptysis (HP:0002105)2.03020593
100Pseudobulbar signs (HP:0002200)1.99464207
101Abnormality of aspartate family amino acid metabolism (HP:0010899)1.97603766
102Keratoconjunctivitis (HP:0001096)1.97472528
103Global brain atrophy (HP:0002283)1.96162956
104Abnormality of the intrinsic pathway (HP:0010989)1.95953171
105Vasculitis (HP:0002633)1.95919668
106Inappropriate behavior (HP:0000719)1.95899916
107Abnormality of the thoracic spine (HP:0100711)1.95429087
108Thin bony cortex (HP:0002753)1.95175112
109Autoimmune hemolytic anemia (HP:0001890)1.94901413
110Subacute progressive viral hepatitis (HP:0006572)1.93168106
111Pustule (HP:0200039)1.92923821
112Conjugated hyperbilirubinemia (HP:0002908)1.92258972
113Amyloidosis (HP:0011034)1.91300404
114Abnormality of nucleobase metabolism (HP:0010932)1.89754162
115Abnormality of macrophages (HP:0004311)1.89461259
116Turricephaly (HP:0000262)1.85260723
117Coarse hair (HP:0002208)1.84823978
118Arterial thrombosis (HP:0004420)1.84668145
119Macroorchidism (HP:0000053)1.83948779
120Abnormality of transition element cation homeostasis (HP:0011030)1.83864418
121Reticulocytosis (HP:0001923)1.83120764
122Hypoplasia of the thymus (HP:0000778)1.81376361
123Increased serum ferritin (HP:0003281)1.81366023
124Apathy (HP:0000741)1.81308435
125Increased neuronal autofluorescent lipopigment (HP:0002074)1.80800044
126Neuronal loss in central nervous system (HP:0002529)1.79842063
127Prominent nose (HP:0000448)1.78850539
128Polycythemia (HP:0001901)1.77721056
129Dysmetric saccades (HP:0000641)1.76177181
130Abnormal enzyme/coenzyme activity (HP:0012379)1.76151726
131Mutism (HP:0002300)1.75699859
132Cellulitis (HP:0100658)1.74585484
133IgA deficiency (HP:0002720)1.74585416
134Persistence of primary teeth (HP:0006335)1.74507144
135Increased CSF protein (HP:0002922)1.73642734
136Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.72263761
137Osteolytic defects of the phalanges of the hand (HP:0009771)1.71735856
138Osteolytic defects of the hand bones (HP:0009699)1.71735856
139Axonal loss (HP:0003447)1.71579831
140Clumsiness (HP:0002312)1.70346869
141Progressive visual loss (HP:0000529)1.70197451
142Gastrointestinal infarctions (HP:0005244)1.70004498
143Restrictive lung disease (HP:0002091)1.69199413
144Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.69048264
145Ovoid vertebral bodies (HP:0003300)1.68775581
146Depressed nasal tip (HP:0000437)1.67872488
147Basal ganglia calcification (HP:0002135)1.67733109
148Absent frontal sinuses (HP:0002688)1.67668003
149Abnormality of the endocardium (HP:0004306)1.66672865
150Diminished motivation (HP:0000745)1.66529459
151Gastrointestinal inflammation (HP:0004386)1.66369130
152Increased mean platelet volume (HP:0011877)1.66317296
153Cardiomegaly (HP:0001640)1.66294062
154Abnormal platelet volume (HP:0011876)1.65022531
155Protuberant abdomen (HP:0001538)1.64546738
156Acanthocytosis (HP:0001927)1.64474289
157Conjunctival telangiectasia (HP:0000524)1.64453855
158Thrombophlebitis (HP:0004418)1.64191250
159Epistaxis (HP:0000421)1.64190591
160Increased IgE level (HP:0003212)1.64164008
161Peripheral demyelination (HP:0011096)1.63152972
162Aneurysm (HP:0002617)1.62913538
163Onion bulb formation (HP:0003383)1.61955869
164Flat acetabular roof (HP:0003180)1.61677492
165Frequent falls (HP:0002359)1.61598948
166Abnormality of alkaline phosphatase activity (HP:0004379)1.61513413
167Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.61330865
168Inflammation of the large intestine (HP:0002037)1.61177757
169Elevated alkaline phosphatase (HP:0003155)1.60961294
170Osteomyelitis (HP:0002754)1.60947953
171Abnormality of fatty-acid metabolism (HP:0004359)1.58153575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.93617394
2TRIB33.09353528
3ERN12.84766744
4CAMK1D2.74115378
5TYK22.69904476
6MAP3K102.59698071
7MAP4K12.58094959
8SIK12.32410465
9CAMK1G2.30482588
10FGFR42.20368302
11TAOK32.07842372
12PRPF4B2.07759483
13JAK11.98859852
14EPHB11.80877363
15MAP3K141.77877419
16PTK61.77644534
17PKN21.75839856
18CDC42BPA1.74850107
19ACVR1B1.72910707
20TTN1.62421579
21CSF1R1.60209543
22BRD41.59037015
23LATS11.58232284
24MAP3K131.56548926
25GRK71.51308361
26ICK1.48905945
27DDR21.46722141
28TBK11.44786332
29KIT1.41595111
30CDK61.33978562
31JAK31.33497230
32RIPK11.33354395
33MTOR1.33249890
34GRK61.32136494
35CHUK1.26124466
36FRK1.25582843
37CSK1.24826738
38STK101.22886930
39NEK21.22777631
40SIK21.22696741
41EEF2K1.21835503
42IKBKE1.21155485
43FGR1.18893825
44MAP3K31.15961254
45IKBKB1.14822073
46HCK1.13050128
47SGK31.12574781
48MARK21.09319370
49FGFR31.06672130
50ZAP701.06330905
51STK41.05475260
52BCKDK1.02816010
53STK31.01481226
54MAPK111.00587394
55JAK21.00534617
56MAP2K30.99699703
57TGFBR20.99285507
58TAOK10.98463632
59IRAK10.97642758
60RIPK40.92674453
61TXK0.92057324
62PRKAA20.90384765
63AKT30.88327271
64MAP3K70.86127634
65FLT30.86071325
66TYRO30.84937244
67CAMKK20.83019743
68BLK0.81712871
69IRAK30.80260102
70PIM10.79635050
71CDK40.76497105
72ADRBK20.73437189
73TAOK20.72755330
74ERBB20.72489351
75INSRR0.72062486
76PRKAA10.71341050
77SGK20.71193431
78RPS6KA20.70988238
79MAP3K10.70862227
80SYK0.68163563
81BMX0.65801858
82HIPK20.65091584
83CDK90.64819251
84BTK0.63760209
85PDGFRB0.61454831
86NLK0.60964047
87PIK3CG0.60773383
88LCK0.59301591
89ALK0.57788770
90MAP3K110.56564216
91EGFR0.55664651
92MARK30.54901395
93FES0.54804937
94DYRK1B0.54788197
95CSNK1A1L0.54300646
96PRKD20.53906371
97ITK0.53157498
98PTK20.53040270
99WNK10.52956723
100STK380.52333863
101RPS6KA60.51839868
102RPS6KC10.51427319
103RPS6KL10.51427319
104PDK10.50403632
105PRKCH0.49071210
106NEK90.48389056
107ABL10.47145956
108IRAK40.46470843
109ERBB40.45707087
110LYN0.45697659
111EPHA30.45212240
112TNK20.45087855
113PDPK10.45027663
114RET0.44718646
115ATR0.44472909
116TRPM70.43848377
117PDGFRA0.43834606
118MELK0.43358312
119MAPK70.42529339
120PKN10.42219834
121CAMK40.41471851
122MAP3K60.39959083
123CSNK1D0.39884776
124MAPK10.38522791
125MATK0.36514618
126MAPK120.36260479
127FGFR20.35700572
128GSK3A0.34713098
129CHEK10.33360429
130RPS6KA40.32498747

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.30958507
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.28867872
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.11886376
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.90976941
5Other glycan degradation_Homo sapiens_hsa005112.67645070
6Arginine biosynthesis_Homo sapiens_hsa002202.55264330
7Staphylococcus aureus infection_Homo sapiens_hsa051502.46076850
8Complement and coagulation cascades_Homo sapiens_hsa046102.45572553
9Lysine degradation_Homo sapiens_hsa003102.16407803
10Caffeine metabolism_Homo sapiens_hsa002322.06346429
11Tryptophan metabolism_Homo sapiens_hsa003802.05176377
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.99601182
13Fatty acid degradation_Homo sapiens_hsa000711.82167602
14ABC transporters_Homo sapiens_hsa020101.75806599
15Allograft rejection_Homo sapiens_hsa053301.72517304
16PPAR signaling pathway_Homo sapiens_hsa033201.67790247
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66872742
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.65821558
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62440826
20Selenocompound metabolism_Homo sapiens_hsa004501.61634989
21Asthma_Homo sapiens_hsa053101.56867235
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53889159
23Graft-versus-host disease_Homo sapiens_hsa053321.50939904
24Malaria_Homo sapiens_hsa051441.50284476
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49096492
26Autoimmune thyroid disease_Homo sapiens_hsa053201.48414028
27Fatty acid metabolism_Homo sapiens_hsa012121.45857775
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44430407
29Rheumatoid arthritis_Homo sapiens_hsa053231.35639546
30B cell receptor signaling pathway_Homo sapiens_hsa046621.31227585
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.29925195
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28854659
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26349765
34Peroxisome_Homo sapiens_hsa041461.26126478
35Pertussis_Homo sapiens_hsa051331.22168506
36Bile secretion_Homo sapiens_hsa049761.19482050
37Prolactin signaling pathway_Homo sapiens_hsa049171.16314749
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.15623478
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15538478
40Starch and sucrose metabolism_Homo sapiens_hsa005001.15329266
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14760022
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13573986
43One carbon pool by folate_Homo sapiens_hsa006701.11412853
44Butanoate metabolism_Homo sapiens_hsa006501.11218214
45Chemical carcinogenesis_Homo sapiens_hsa052041.09948976
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09279034
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08957170
48beta-Alanine metabolism_Homo sapiens_hsa004101.08453999
49Insulin resistance_Homo sapiens_hsa049311.06108667
50Vitamin B6 metabolism_Homo sapiens_hsa007501.05225056
51African trypanosomiasis_Homo sapiens_hsa051431.04709089
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04634331
53Osteoclast differentiation_Homo sapiens_hsa043801.04397537
54Hematopoietic cell lineage_Homo sapiens_hsa046401.03718081
55Dorso-ventral axis formation_Homo sapiens_hsa043201.03688008
56Retinol metabolism_Homo sapiens_hsa008301.02661392
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02315332
58Glycerolipid metabolism_Homo sapiens_hsa005611.02218203
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01783375
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.00888847
61Chemokine signaling pathway_Homo sapiens_hsa040620.98556826
62Histidine metabolism_Homo sapiens_hsa003400.96027021
63Sphingolipid metabolism_Homo sapiens_hsa006000.94110896
64Phagosome_Homo sapiens_hsa041450.93636750
65Leishmaniasis_Homo sapiens_hsa051400.93595710
66VEGF signaling pathway_Homo sapiens_hsa043700.92858818
67Viral myocarditis_Homo sapiens_hsa054160.92180216
68Type I diabetes mellitus_Homo sapiens_hsa049400.90226778
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89939602
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88598215
71Biosynthesis of amino acids_Homo sapiens_hsa012300.87997804
72Propanoate metabolism_Homo sapiens_hsa006400.87033931
73Measles_Homo sapiens_hsa051620.85519388
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84922347
75Legionellosis_Homo sapiens_hsa051340.83639993
76Pentose phosphate pathway_Homo sapiens_hsa000300.82834467
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.82712607
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.82540421
79Fat digestion and absorption_Homo sapiens_hsa049750.82381195
80Amoebiasis_Homo sapiens_hsa051460.82211668
81Platelet activation_Homo sapiens_hsa046110.82114868
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81943230
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.78801623
84Renal cell carcinoma_Homo sapiens_hsa052110.78146748
85Influenza A_Homo sapiens_hsa051640.76609957
86Bladder cancer_Homo sapiens_hsa052190.75371863
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.75115637
88mTOR signaling pathway_Homo sapiens_hsa041500.74199803
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.73158254
90Phenylalanine metabolism_Homo sapiens_hsa003600.72855636
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72461584
92FoxO signaling pathway_Homo sapiens_hsa040680.72270837
93Primary immunodeficiency_Homo sapiens_hsa053400.70753570
94Lysosome_Homo sapiens_hsa041420.70648585
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68423884
96GnRH signaling pathway_Homo sapiens_hsa049120.67971636
97Carbon metabolism_Homo sapiens_hsa012000.67937015
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67644332
99Acute myeloid leukemia_Homo sapiens_hsa052210.67086721
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65271331
101Type II diabetes mellitus_Homo sapiens_hsa049300.65051556
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.64732784
103Salmonella infection_Homo sapiens_hsa051320.64636931
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62544500
105Toxoplasmosis_Homo sapiens_hsa051450.61302027
106Chronic myeloid leukemia_Homo sapiens_hsa052200.60699992
107Prostate cancer_Homo sapiens_hsa052150.60621020
108Systemic lupus erythematosus_Homo sapiens_hsa053220.60273038
109Vitamin digestion and absorption_Homo sapiens_hsa049770.60179753
110Fatty acid biosynthesis_Homo sapiens_hsa000610.59689668
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59284431
112Endometrial cancer_Homo sapiens_hsa052130.58805401
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58585536
114Hepatitis C_Homo sapiens_hsa051600.57866596
115Steroid biosynthesis_Homo sapiens_hsa001000.57406386
116Tuberculosis_Homo sapiens_hsa051520.57268567
117Herpes simplex infection_Homo sapiens_hsa051680.56371593
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56358093
119Tyrosine metabolism_Homo sapiens_hsa003500.55972311
120Viral carcinogenesis_Homo sapiens_hsa052030.55743123
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55342607
122Proteoglycans in cancer_Homo sapiens_hsa052050.55035831
123Small cell lung cancer_Homo sapiens_hsa052220.53425978
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.52407154
125ErbB signaling pathway_Homo sapiens_hsa040120.52042036
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51915507
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50134269
128Choline metabolism in cancer_Homo sapiens_hsa052310.49678334
129Focal adhesion_Homo sapiens_hsa045100.49462831
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.49102150
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48975847
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.48746171
133Apoptosis_Homo sapiens_hsa042100.48282159
134Estrogen signaling pathway_Homo sapiens_hsa049150.46856984
135MAPK signaling pathway_Homo sapiens_hsa040100.46831572
136Antigen processing and presentation_Homo sapiens_hsa046120.46492591
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46222461
138AMPK signaling pathway_Homo sapiens_hsa041520.45244887
139Non-small cell lung cancer_Homo sapiens_hsa052230.43854297
140TNF signaling pathway_Homo sapiens_hsa046680.43548076
141Notch signaling pathway_Homo sapiens_hsa043300.43205999
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42997728
143Fatty acid elongation_Homo sapiens_hsa000620.42123538
144Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39211361
145Pancreatic cancer_Homo sapiens_hsa052120.38801873
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36111126
147Pyruvate metabolism_Homo sapiens_hsa006200.34944092
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.34760630
149MicroRNAs in cancer_Homo sapiens_hsa052060.34575252
150Inositol phosphate metabolism_Homo sapiens_hsa005620.34506961
151T cell receptor signaling pathway_Homo sapiens_hsa046600.34369505
152Leukocyte transendothelial migration_Homo sapiens_hsa046700.33841608
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33129346
154Hepatitis B_Homo sapiens_hsa051610.32396934
155Insulin signaling pathway_Homo sapiens_hsa049100.31542764

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