ZFYVE27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.11556080
2presynaptic membrane organization (GO:0097090)5.08931566
3regulation of synaptic vesicle exocytosis (GO:2000300)4.94540818
4presynaptic membrane assembly (GO:0097105)4.75057017
5synaptic vesicle maturation (GO:0016188)4.73078712
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.70855801
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.63758280
8synaptic vesicle exocytosis (GO:0016079)4.60606656
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.58264112
10negative regulation of cell killing (GO:0031342)4.58264112
11glutamate secretion (GO:0014047)4.46123358
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.39734880
13locomotory exploration behavior (GO:0035641)4.35809887
14vocalization behavior (GO:0071625)4.35526303
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.31887035
16regulation of synaptic vesicle transport (GO:1902803)4.31617282
17neuron cell-cell adhesion (GO:0007158)4.30760324
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.25999708
19protein localization to synapse (GO:0035418)4.22304489
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.07200832
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.05354680
22regulation of glutamate receptor signaling pathway (GO:1900449)4.01744865
23negative regulation of erythrocyte differentiation (GO:0045647)3.97851449
24neuronal action potential propagation (GO:0019227)3.96728097
25antigen processing and presentation of endogenous antigen (GO:0019883)3.92774197
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.92406170
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.89190982
28neurotransmitter-gated ion channel clustering (GO:0072578)3.88914048
29neurotransmitter secretion (GO:0007269)3.86996638
30synaptic transmission, glutamatergic (GO:0035249)3.78374617
31modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.75884526
32modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.75884526
33positive regulation by organism of defense response of other organism involved in symbiotic interact3.75884526
34modulation by symbiont of host immune response (GO:0052553)3.75884526
35positive regulation by symbiont of host defense response (GO:0052509)3.75884526
36modulation by symbiont of host defense response (GO:0052031)3.75884526
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.69133467
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.64814690
39positive regulation of gamma-delta T cell activation (GO:0046645)3.63387429
40regulation of neuronal synaptic plasticity (GO:0048168)3.58583825
41positive regulation of synaptic transmission, GABAergic (GO:0032230)3.55327869
42neuron-neuron synaptic transmission (GO:0007270)3.53331030
43postsynaptic membrane organization (GO:0001941)3.52309659
44glutamate receptor signaling pathway (GO:0007215)3.46730689
45positive regulation of membrane potential (GO:0045838)3.42824229
46mannose metabolic process (GO:0006013)3.41429117
47regulation of long-term neuronal synaptic plasticity (GO:0048169)3.41236338
48proline transport (GO:0015824)3.38645462
49exploration behavior (GO:0035640)3.37741988
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34943187
51layer formation in cerebral cortex (GO:0021819)3.25480072
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.24462497
53regulation of vesicle fusion (GO:0031338)3.20759750
54regulation of neurotransmitter secretion (GO:0046928)3.20429194
55positive regulation of synapse maturation (GO:0090129)3.18563588
56cellular potassium ion homeostasis (GO:0030007)3.18532048
57regulation of postsynaptic membrane potential (GO:0060078)3.18175811
58regulation of synapse structural plasticity (GO:0051823)3.17227121
59neurotransmitter transport (GO:0006836)3.14805544
60long-term memory (GO:0007616)3.13328495
61cerebellar Purkinje cell differentiation (GO:0021702)3.13285135
62nerve growth factor signaling pathway (GO:0038180)3.11456003
63macrophage activation involved in immune response (GO:0002281)3.11179980
64gamma-aminobutyric acid transport (GO:0015812)3.08728101
65response to muramyl dipeptide (GO:0032495)3.07577758
66synaptic vesicle endocytosis (GO:0048488)3.07530355
67regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.07111778
68membrane depolarization during action potential (GO:0086010)3.06143558
69detection of other organism (GO:0098543)3.05749009
70detection of bacterium (GO:0016045)3.04945834
71NIK/NF-kappaB signaling (GO:0038061)3.04937817
72neuron recognition (GO:0008038)3.02514759
73positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.02504673
74long-term synaptic potentiation (GO:0060291)3.02475126
75membrane hyperpolarization (GO:0060081)3.01277797
76G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.00027191
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99765654
78regulation of synaptic transmission, GABAergic (GO:0032228)2.97060116
79positive regulation of neurotransmitter transport (GO:0051590)2.92930228
80positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.91518555
81regulation of neurotransmitter transport (GO:0051588)2.91481442
82membrane depolarization (GO:0051899)2.91183269
83glycine transport (GO:0015816)2.90277685
84gamma-aminobutyric acid signaling pathway (GO:0007214)2.88690764
85positive regulation of neurotransmitter secretion (GO:0001956)2.88613708
86regulation of synaptic plasticity (GO:0048167)2.88307679
87leukocyte aggregation (GO:0070486)2.88195772
88negative regulation of lymphocyte mediated immunity (GO:0002707)2.87896131
89regulation of neurotransmitter levels (GO:0001505)2.87305726
90regulation of regulated secretory pathway (GO:1903305)2.86838428
91regulation of synaptic transmission, glutamatergic (GO:0051966)2.85250574
92regulation of ARF GTPase activity (GO:0032312)2.84447201
93negative regulation of leukocyte mediated immunity (GO:0002704)2.83180493
94transmission of nerve impulse (GO:0019226)2.82602741
95positive regulation of synapse assembly (GO:0051965)2.81339536
96regulation of exocytosis (GO:0017157)2.80720648
97cell migration in hindbrain (GO:0021535)2.79424477
98regulation of synapse maturation (GO:0090128)2.79266902
99response to peptidoglycan (GO:0032494)2.78133184
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.77917836
101germinal center formation (GO:0002467)2.76969745
102positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76260845
103regulation of B cell receptor signaling pathway (GO:0050855)2.76176639
104regulation of ARF protein signal transduction (GO:0032012)2.74558160
105negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.73867901
106regulation of gamma-delta T cell activation (GO:0046643)2.73701042
107synapse assembly (GO:0007416)2.73095955
108response to pheromone (GO:0019236)2.72784197
109dendritic spine morphogenesis (GO:0060997)2.72739110
110positive regulation of synaptic transmission (GO:0050806)2.72618124
111innervation (GO:0060384)2.71280988
112cerebellar granule cell differentiation (GO:0021707)2.71195816
113dendrite morphogenesis (GO:0048813)2.70986808
114positive regulation of exocytosis (GO:0045921)2.70579748
115activation of protein kinase A activity (GO:0034199)2.70263599
116protein localization to endosome (GO:0036010)2.68929801
117neuronal action potential (GO:0019228)2.67600516
118neuronal ion channel clustering (GO:0045161)2.67584817
119negative regulation of interleukin-12 production (GO:0032695)2.65939199
120regulation of voltage-gated calcium channel activity (GO:1901385)2.65864031
121axonal fasciculation (GO:0007413)2.65649703
122regulation of interferon-beta biosynthetic process (GO:0045357)2.64596208
123regulation of defense response to virus by virus (GO:0050690)2.63185446
124negative regulation of toll-like receptor signaling pathway (GO:0034122)2.62244925
125neuromuscular synaptic transmission (GO:0007274)2.62142544
126regulation of calcium ion-dependent exocytosis (GO:0017158)2.60054313
127mechanosensory behavior (GO:0007638)2.60049253
128B cell receptor signaling pathway (GO:0050853)2.59511306
129mating behavior (GO:0007617)2.58007656
130cellular response to type I interferon (GO:0071357)2.57619339
131type I interferon signaling pathway (GO:0060337)2.57619339
132neuromuscular process controlling balance (GO:0050885)2.57073481
133regulation of leukocyte degranulation (GO:0043300)2.56901435
134regulation of synaptic transmission (GO:0050804)2.56329003
135positive regulation of vesicle fusion (GO:0031340)2.56328061
136retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.56017488
137synaptic vesicle transport (GO:0048489)2.55846958
138establishment of synaptic vesicle localization (GO:0097480)2.55846958
139response to host immune response (GO:0052572)2.55419055
140response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.55419055
141synaptic transmission (GO:0007268)2.55184352
142startle response (GO:0001964)2.54804593
143regulation of T-helper 2 cell differentiation (GO:0045628)2.54237207
144response to type I interferon (GO:0034340)2.53447980
145positive thymic T cell selection (GO:0045059)2.50781110
146Arp2/3 complex-mediated actin nucleation (GO:0034314)2.50107071
147signal complex assembly (GO:0007172)2.48552027
148Golgi transport vesicle coating (GO:0048200)2.48363266
149COPI coating of Golgi vesicle (GO:0048205)2.48363266
150respiratory burst (GO:0045730)2.47141671
151regulation of mast cell degranulation (GO:0043304)2.46781933
152positive regulation of Rap GTPase activity (GO:0032854)2.45944945
153regulation of myeloid leukocyte mediated immunity (GO:0002886)2.45671497
154detection of external biotic stimulus (GO:0098581)2.44789987
155negative regulation of glycoprotein biosynthetic process (GO:0010561)2.44413062
156negative regulation of glial cell proliferation (GO:0060253)2.44405547
157regulation of cellular amide metabolic process (GO:0034248)2.43769101
158positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.41679163
159activation of MAPKKK activity (GO:0000185)2.41558418
160regulation of gamma-delta T cell differentiation (GO:0045586)2.38826743
161thymic T cell selection (GO:0045061)2.36801695
162establishment of mitochondrion localization (GO:0051654)2.35826938
163positive regulation of regulated secretory pathway (GO:1903307)2.35455996
164negative thymic T cell selection (GO:0045060)2.35307125
165response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.34588065
166response to host (GO:0075136)2.34588065
167response to host defenses (GO:0052200)2.34588065
168regulation of amyloid precursor protein catabolic process (GO:1902991)2.34532801
169negative regulation of type 2 immune response (GO:0002829)2.34381077
170amino acid import (GO:0043090)2.33423363
171negative regulation of cell size (GO:0045792)2.32789623
172barbed-end actin filament capping (GO:0051016)2.31887405
173positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.30179828
174T cell selection (GO:0045058)2.28632000
175glucose 6-phosphate metabolic process (GO:0051156)2.26331320
176intracellular estrogen receptor signaling pathway (GO:0030520)2.25933867
177negative T cell selection (GO:0043383)2.24417997
178positive T cell selection (GO:0043368)2.23988082
179response to laminar fluid shear stress (GO:0034616)2.23281444
180negative regulation of T cell mediated immunity (GO:0002710)2.20897644
181L-amino acid import (GO:0043092)2.20838335
182adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.19047735
183actin filament polymerization (GO:0030041)2.18922841
184negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.18081468
185regulation of mast cell activation involved in immune response (GO:0033006)2.17125438
186positive regulation of Cdc42 GTPase activity (GO:0043089)2.12892012

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.71825009
2GBX2_23144817_ChIP-Seq_PC3_Human3.54098613
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.16271904
4VDR_21846776_ChIP-Seq_THP-1_Human2.99122353
5LXR_22292898_ChIP-Seq_THP-1_Human2.84936066
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.75230328
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69701011
8DROSHA_22980978_ChIP-Seq_HELA_Human2.69677897
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.57831635
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56173688
11REST_21632747_ChIP-Seq_MESCs_Mouse2.54025563
12MYC_22102868_ChIP-Seq_BL_Human2.47478082
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.40028508
14KDM2B_26808549_Chip-Seq_DND41_Human2.39344614
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33786380
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31163677
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.30880128
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.30088538
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25692704
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25420634
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.19195337
22TCF7_22412390_ChIP-Seq_EML_Mouse2.19145306
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18155986
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18155986
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11114192
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08132861
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.07210686
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06844208
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06782688
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05933219
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05869315
32EZH2_27294783_Chip-Seq_ESCs_Mouse2.04260245
33EZH2_27304074_Chip-Seq_ESCs_Mouse2.03585647
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.99800993
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98426937
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.95081224
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.93433545
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.92375063
39VDR_24763502_ChIP-Seq_THP-1_Human1.85810713
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85046171
41MAF_26560356_Chip-Seq_TH1_Human1.83566126
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83434267
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81470497
44UTX_26944678_Chip-Seq_JUKART_Human1.79519458
45* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.79315768
46* P68_20966046_ChIP-Seq_HELA_Human1.78875063
47RACK7_27058665_Chip-Seq_MCF-7_Human1.77498691
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74975035
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.74736867
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.71432389
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.71315519
52MAF_26560356_Chip-Seq_TH2_Human1.70994880
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69556096
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69210183
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68386313
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.68018036
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.66935631
58SMC4_20622854_ChIP-Seq_HELA_Human1.66270069
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.66113941
60TAF15_26573619_Chip-Seq_HEK293_Human1.65510914
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63445126
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.62346918
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.61265932
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59102965
65SMAD4_21799915_ChIP-Seq_A2780_Human1.57277654
66* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56083634
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55938330
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.54907196
69BCOR_27268052_Chip-Seq_Bcells_Human1.53450280
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53014393
71BCL6_27268052_Chip-Seq_Bcells_Human1.52575189
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52285569
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.51821821
74* GATA1_19941827_ChIP-Seq_MEL_Mouse1.51266759
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50904894
76AR_21572438_ChIP-Seq_LNCaP_Human1.49816660
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.47751740
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46168788
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44342091
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42660212
81CREB1_26743006_Chip-Seq_LNCaP_Human1.42208580
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41901000
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40783807
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.39200196
85SPI1_23127762_ChIP-Seq_K562_Human1.38638862
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36158900
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35454918
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33554887
89STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32511227
90AHR_22903824_ChIP-Seq_MCF-7_Human1.31601197
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.30835331
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30473928
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28848407
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26564790
95BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26442771
96EGR1_19374776_ChIP-ChIP_THP-1_Human1.25445572
97* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24920349
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24773005
99STAT3_23295773_ChIP-Seq_U87_Human1.23712544
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23399985
101IRF8_27001747_Chip-Seq_BMDM_Mouse1.22689748
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.22262119
103SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20972907
104DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20956457
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20216287
106P300_19829295_ChIP-Seq_ESCs_Human1.19950302
107SA1_27219007_Chip-Seq_Bcells_Human1.18885481
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18765755
109* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17963634
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17935098
111IRF8_21731497_ChIP-ChIP_J774_Mouse1.17307954
112GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17132663
113STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16827181
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.15467894
115KDM2B_26808549_Chip-Seq_K562_Human1.14618839
116CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14384131
117* TCF4_23295773_ChIP-Seq_U87_Human1.13436787
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13387980
119PHF8_20622854_ChIP-Seq_HELA_Human1.12728686
120AR_25329375_ChIP-Seq_VCAP_Human1.12552718
121* AR_19668381_ChIP-Seq_PC3_Human1.12079993
122CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11956588
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10265646
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09768874
125CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09534784
126* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09309383
127* CTCF_27219007_Chip-Seq_Bcells_Human1.09069102
128* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08498984
129ERG_21242973_ChIP-ChIP_JURKAT_Human1.08348937
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07168791
131TP63_17297297_ChIP-ChIP_HaCaT_Human1.06995893
132P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06850415
133P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06478650
134NCOR1_26117541_ChIP-Seq_K562_Human1.05978932
135GATA1_19941826_ChIP-Seq_K562_Human1.05482700
136PIAS1_25552417_ChIP-Seq_VCAP_Human1.05076340
137SPI1_23547873_ChIP-Seq_NB4_Human1.05051835
138PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05008810
139OCT4_19829295_ChIP-Seq_ESCs_Human1.04986307
140ESR2_21235772_ChIP-Seq_MCF-7_Human1.04568849
141ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04061090
142BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03827559
143FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03574962
144* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03340618
145SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03333018
146* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02442266
147KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02311410
148NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02235693
149SMAD3_21741376_ChIP-Seq_ESCs_Human1.02118712
150RING1B_27294783_Chip-Seq_ESCs_Mouse1.02111460
151POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01962604
152CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01650396
153ZNF274_21170338_ChIP-Seq_K562_Hela1.01380043
154SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01159250
155TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00190066
156AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99873304
157TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99702988
158YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99653290
159CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99096662
160KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97654218
161* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96723757
162SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95080469
163ER_23166858_ChIP-Seq_MCF-7_Human0.94310706
164SMAD4_21741376_ChIP-Seq_HESCs_Human0.94098874
165PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94096235
166TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93462595
167CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93165166
168* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92878159
169RUNX2_22187159_ChIP-Seq_PCA_Human0.92420410
170RNF2_27304074_Chip-Seq_NSC_Mouse0.92369709
171MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91947990
172PRDM14_20953172_ChIP-Seq_ESCs_Human0.91275058
173RXR_22108803_ChIP-Seq_LS180_Human0.91199066
174TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90894287
175POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90840236
176TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90840236
177OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90281698
178RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88672268
179STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88493928
180CBX2_27304074_Chip-Seq_ESCs_Mouse0.88356789
181WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87975197
182RING1B_27294783_Chip-Seq_NPCs_Mouse0.86270645
183TET1_21490601_ChIP-Seq_MESCs_Mouse0.85136743
184TP53_16413492_ChIP-PET_HCT116_Human0.85106037

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.16089511
2MP0003880_abnormal_central_pattern3.89870263
3MP0003635_abnormal_synaptic_transmissio3.69321871
4MP0008260_abnormal_autophagy3.66750269
5MP0003436_decreased_susceptibility_to3.53997481
6MP0004270_analgesia3.36569384
7MP0001968_abnormal_touch/_nociception3.10674294
8MP0002735_abnormal_chemical_nociception3.04993832
9MP0009745_abnormal_behavioral_response3.01690091
10MP0005451_abnormal_body_composition2.89309478
11MP0009046_muscle_twitch2.88371014
12MP0002064_seizures2.86223111
13MP0002063_abnormal_learning/memory/cond2.83693229
14MP0003724_increased_susceptibility_to2.60593504
15MP0002734_abnormal_mechanical_nocicepti2.58512272
16MP0005058_abnormal_lysosome_morphology2.48131069
17MP0002572_abnormal_emotion/affect_behav2.47902394
18MP0002272_abnormal_nervous_system2.46988321
19MP0009840_abnormal_foam_cell2.46847221
20MP0002736_abnormal_nociception_after2.44959125
21MP0009780_abnormal_chondrocyte_physiolo2.44659724
22MP0005423_abnormal_somatic_nervous2.44158295
23MP0002733_abnormal_thermal_nociception2.33758275
24MP0001486_abnormal_startle_reflex2.23017432
25MP0001970_abnormal_pain_threshold2.08152994
26MP0002067_abnormal_sensory_capabilities2.06971246
27MP0008569_lethality_at_weaning2.03646058
28MP0005025_abnormal_response_to2.01251916
29MP0002419_abnormal_innate_immunity2.00924175
30MP0005646_abnormal_pituitary_gland2.00661626
31MP0005000_abnormal_immune_tolerance1.99806369
32MP0005387_immune_system_phenotype1.94378959
33MP0001790_abnormal_immune_system1.94378959
34MP0009278_abnormal_bone_marrow1.93669711
35MP0002822_catalepsy1.91193735
36MP0003183_abnormal_peptide_metabolism1.91060046
37MP0003300_gastrointestinal_ulcer1.90434859
38MP0000569_abnormal_digit_pigmentation1.89824315
39MP0004858_abnormal_nervous_system1.89606028
40MP0001501_abnormal_sleep_pattern1.88879595
41MP0003787_abnormal_imprinting1.87955432
42MP0004947_skin_inflammation1.86853667
43MP0002909_abnormal_adrenal_gland1.86174276
44MP0003191_abnormal_cellular_cholesterol1.83841451
45MP0000685_abnormal_immune_system1.81992130
46MP0003329_amyloid_beta_deposits1.81502818
47MP0001440_abnormal_grooming_behavior1.81240267
48MP0006276_abnormal_autonomic_nervous1.79351710
49MP0001800_abnormal_humoral_immune1.76858510
50MP0001835_abnormal_antigen_presentation1.75995587
51MP0002184_abnormal_innervation1.74332472
52MP0005671_abnormal_response_to1.72003220
53MP0001188_hyperpigmentation1.70654333
54MP0004811_abnormal_neuron_physiology1.69361612
55MP0002723_abnormal_immune_serum1.68823160
56MP0009785_altered_susceptibility_to1.67118143
57MP0001984_abnormal_olfaction1.65407897
58MP0005386_behavior/neurological_phenoty1.64295488
59MP0004924_abnormal_behavior1.64295488
60MP0000778_abnormal_nervous_system1.62604779
61MP0002420_abnormal_adaptive_immunity1.59128562
62MP0002557_abnormal_social/conspecific_i1.58849274
63MP0001819_abnormal_immune_cell1.58574843
64MP0010155_abnormal_intestine_physiology1.57969006
65MP0001502_abnormal_circadian_rhythm1.56274048
66MP0005645_abnormal_hypothalamus_physiol1.54848699
67MP0000015_abnormal_ear_pigmentation1.54051408
68MP0004885_abnormal_endolymph1.53595208
69MP0002452_abnormal_antigen_presenting1.52994827
70MP0005551_abnormal_eye_electrophysiolog1.51524880
71MP0003866_abnormal_defecation1.50777385
72MP0003879_abnormal_hair_cell1.49773454
73MP0001533_abnormal_skeleton_physiology1.46253471
74MP0003763_abnormal_thymus_physiology1.46231430
75MP0000955_abnormal_spinal_cord1.44559087
76MP0001986_abnormal_taste_sensitivity1.44238121
77MP0003633_abnormal_nervous_system1.43464943
78MP0003172_abnormal_lysosome_physiology1.43181004
79MP0002882_abnormal_neuron_morphology1.42228391
80MP0003656_abnormal_erythrocyte_physiolo1.37728249
81MP0003075_altered_response_to1.34712874
82MP0010386_abnormal_urinary_bladder1.32992423
83MP0004510_myositis1.28450577
84MP0002229_neurodegeneration1.27635418
85MP0000716_abnormal_immune_system1.26195357
86MP0001545_abnormal_hematopoietic_system1.25502779
87MP0005397_hematopoietic_system_phenotyp1.25502779
88MP0004742_abnormal_vestibular_system1.24450071
89MP0005464_abnormal_platelet_physiology1.23354890
90MP0002066_abnormal_motor_capabilities/c1.22945547
91MP0002398_abnormal_bone_marrow1.20915913
92MP0006082_CNS_inflammation1.20695885
93MP0003123_paternal_imprinting1.19540497
94MP0000858_altered_metastatic_potential1.18176727
95MP0003631_nervous_system_phenotype1.17277853
96MP0002405_respiratory_system_inflammati1.17125761
97MP0001905_abnormal_dopamine_level1.16780073
98MP0002876_abnormal_thyroid_physiology1.15755846
99MP0002132_abnormal_respiratory_system1.15562931
100MP0002638_abnormal_pupillary_reflex1.12948790
101MP0001845_abnormal_inflammatory_respons1.12516769
102MP0001529_abnormal_vocalization1.10442064
103MP0009333_abnormal_splenocyte_physiolog1.10054933
104MP0003303_peritoneal_inflammation1.07976194
105MP0002148_abnormal_hypersensitivity_rea1.06671255
106MP0003634_abnormal_glial_cell1.04868467
107MP0001849_ear_inflammation1.04446289
108MP0000920_abnormal_myelination1.01478321
109MP0004142_abnormal_muscle_tone1.00872508
110MP0005409_darkened_coat_color1.00153102
111MP0002429_abnormal_blood_cell0.99656768
112MP0002877_abnormal_melanocyte_morpholog0.98929254
113MP0002998_abnormal_bone_remodeling0.97444725
114MP0004130_abnormal_muscle_cell0.96728463
115MP0002722_abnormal_immune_system0.95512400
116MP0008961_abnormal_basal_metabolism0.95330906
117MP0008874_decreased_physiological_sensi0.94260603
118MP0002152_abnormal_brain_morphology0.92949289
119MP0005166_decreased_susceptibility_to0.90940422
120MP0008469_abnormal_protein_level0.90544046
121MP0000013_abnormal_adipose_tissue0.89810877
122MP0002234_abnormal_pharynx_morphology0.88730405
123MP0002069_abnormal_eating/drinking_beha0.88618727
124MP0000703_abnormal_thymus_morphology0.86787122
125MP0000689_abnormal_spleen_morphology0.86246317
126MP0001963_abnormal_hearing_physiology0.85000014
127MP0003632_abnormal_nervous_system0.84467692
128MP0005535_abnormal_body_temperature0.83156571
129MP0002090_abnormal_vision0.82830094
130MP0001664_abnormal_digestion0.81485115
131MP0002752_abnormal_somatic_nervous0.80533270
132MP0002837_dystrophic_cardiac_calcinosis0.80199371
133MP0003221_abnormal_cardiomyocyte_apopto0.79276723
134MP0000490_abnormal_crypts_of0.78985542
135MP0000465_gastrointestinal_hemorrhage0.78103232
136MP0000604_amyloidosis0.77494927
137MP0005253_abnormal_eye_physiology0.76375175
138MP0010234_abnormal_vibrissa_follicle0.75751285
139MP0003690_abnormal_glial_cell0.74564818
140MP0003453_abnormal_keratinocyte_physiol0.73141103
141MP0002933_joint_inflammation0.72325644
142MP0005310_abnormal_salivary_gland0.71942170
143MP0000631_abnormal_neuroendocrine_gland0.71789831
144MP0009764_decreased_sensitivity_to0.70399374
145MP0000681_abnormal_thyroid_gland0.69182363
146MP0003091_abnormal_cell_migration0.69113236
147MP0002751_abnormal_autonomic_nervous0.68450372
148MP0005584_abnormal_enzyme/coenzyme_acti0.68192616
149MP0001663_abnormal_digestive_system0.67652204
150MP0005499_abnormal_olfactory_system0.67474534
151MP0005394_taste/olfaction_phenotype0.67474534
152MP0008872_abnormal_physiological_respon0.66934245
153MP0005174_abnormal_tail_pigmentation0.66803544
154MP0001851_eye_inflammation0.66330158
155MP0004381_abnormal_hair_follicle0.65386308
156MP0000751_myopathy0.65211101
157MP0006072_abnormal_retinal_apoptosis0.64686595
158MP0001177_atelectasis0.64540647
159MP0004145_abnormal_muscle_electrophysio0.62107571
160MP0003122_maternal_imprinting0.61385192
161MP0000343_altered_response_to0.61383074
162MP0002928_abnormal_bile_duct0.60953763
163MP0003283_abnormal_digestive_organ0.60845197
164MP0004085_abnormal_heartbeat0.60463683
165MP0003868_abnormal_feces_composition0.55321168
166MP0003045_fibrosis0.54046478
167MP0001348_abnormal_lacrimal_gland0.53350979

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.20205843
2Atonic seizures (HP:0010819)4.77576687
3Focal seizures (HP:0007359)4.71454794
4Myokymia (HP:0002411)4.68956821
5Febrile seizures (HP:0002373)4.63643270
6Eczematoid dermatitis (HP:0000976)4.63504922
7Epileptic encephalopathy (HP:0200134)4.32415849
8Visual hallucinations (HP:0002367)4.14294292
9Progressive cerebellar ataxia (HP:0002073)3.65931661
10Supranuclear gaze palsy (HP:0000605)3.63562029
11Orchitis (HP:0100796)3.37116409
12Absence seizures (HP:0002121)3.31811525
13Myositis (HP:0100614)3.27615071
14Abnormality of macrophages (HP:0004311)3.24653729
15Action tremor (HP:0002345)3.13402107
16Dialeptic seizures (HP:0011146)3.11826911
17Recurrent bacterial skin infections (HP:0005406)3.06253707
18* Ankle clonus (HP:0011448)3.04970824
19Scanning speech (HP:0002168)3.04353524
20Optic neuritis (HP:0100653)3.03906198
21Retrobulbar optic neuritis (HP:0100654)3.03906198
22Recurrent abscess formation (HP:0002722)3.00278022
23Depression (HP:0000716)3.00192468
24Generalized tonic-clonic seizures (HP:0002069)2.97311531
25Slow saccadic eye movements (HP:0000514)2.96875295
26Truncal ataxia (HP:0002078)2.92570185
27Urinary bladder sphincter dysfunction (HP:0002839)2.89959040
28Gaze-evoked nystagmus (HP:0000640)2.89205266
29Dysostosis multiplex (HP:0000943)2.88929819
30Gingivitis (HP:0000230)2.86770168
31Broad-based gait (HP:0002136)2.84399035
32Impaired vibration sensation in the lower limbs (HP:0002166)2.82019905
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.81588900
34Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.79198324
35Absent speech (HP:0001344)2.76628292
36Peripheral hypomyelination (HP:0007182)2.76322664
37Abnormality of the corticospinal tract (HP:0002492)2.73990202
38Insidious onset (HP:0003587)2.68090661
39Termporal pattern (HP:0011008)2.68090661
40Abnormal eating behavior (HP:0100738)2.67796743
41* Spastic gait (HP:0002064)2.67697317
42Hyperventilation (HP:0002883)2.63933025
43Cellulitis (HP:0100658)2.61872491
44Failure to thrive in infancy (HP:0001531)2.61865424
45Limb dystonia (HP:0002451)2.60741532
46Mediastinal lymphadenopathy (HP:0100721)2.60154048
47Papilledema (HP:0001085)2.57089019
48Mucopolysacchariduria (HP:0008155)2.55887685
49Urinary glycosaminoglycan excretion (HP:0003541)2.55887685
50Abnormality of polysaccharide metabolism (HP:0011012)2.55499600
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.55499600
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.55499600
53Genetic anticipation (HP:0003743)2.53374908
54Upper limb amyotrophy (HP:0009129)2.49907096
55Distal upper limb amyotrophy (HP:0007149)2.49907096
56Urinary urgency (HP:0000012)2.49060134
57Obstructive sleep apnea (HP:0002870)2.46797724
58Protruding tongue (HP:0010808)2.45733946
59Retinal dysplasia (HP:0007973)2.44028708
60Retinal atrophy (HP:0001105)2.43365139
61Meningitis (HP:0001287)2.41965689
62Loss of speech (HP:0002371)2.40239202
63Poor eye contact (HP:0000817)2.36977802
64Abnormality of the lower motor neuron (HP:0002366)2.36842265
65Pheochromocytoma (HP:0002666)2.36332055
66Inability to walk (HP:0002540)2.36256211
67Hand muscle atrophy (HP:0009130)2.35388649
68Epileptiform EEG discharges (HP:0011182)2.34868240
69Bradykinesia (HP:0002067)2.34600431
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.34351053
71Reticulocytosis (HP:0001923)2.33804463
72Dysmetria (HP:0001310)2.32841097
73Degeneration of the lateral corticospinal tracts (HP:0002314)2.31966801
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31966801
75Chronic obstructive pulmonary disease (HP:0006510)2.29072417
76Obstructive lung disease (HP:0006536)2.29072417
77Impaired social interactions (HP:0000735)2.29013749
78Abnormal social behavior (HP:0012433)2.29013749
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.28844481
80Recurrent gram-negative bacterial infections (HP:0005420)2.28692011
81Anxiety (HP:0000739)2.28686328
82Hypoplasia of the brainstem (HP:0002365)2.28342898
83Aplasia/Hypoplasia of the brainstem (HP:0007362)2.28342898
84Increased IgE level (HP:0003212)2.27510665
85EEG with generalized epileptiform discharges (HP:0011198)2.26672402
86Interstitial pulmonary disease (HP:0006530)2.24988306
87Agitation (HP:0000713)2.24643448
88Hypothermia (HP:0002045)2.23526730
89Postural instability (HP:0002172)2.23239147
90Excessive salivation (HP:0003781)2.22836434
91Drooling (HP:0002307)2.22836434
92Hemorrhage of the eye (HP:0011885)2.21968788
93Abnormality of liposaccharide metabolism (HP:0010968)2.21620327
94Abnormality of glycosphingolipid metabolism (HP:0004343)2.21620327
95Abnormality of glycolipid metabolism (HP:0010969)2.21620327
96Progressive inability to walk (HP:0002505)2.20606427
97Increased cerebral lipofuscin (HP:0011813)2.19905042
98Mutism (HP:0002300)2.19328747
99Recurrent fungal infections (HP:0002841)2.19327079
100Akinesia (HP:0002304)2.18850919
101Congenital stationary night blindness (HP:0007642)2.17458665
102Impaired smooth pursuit (HP:0007772)2.16980374
103Stereotypic behavior (HP:0000733)2.15637273
104Abnormal hair whorl (HP:0010721)2.15145076
105Amblyopia (HP:0000646)2.11874517
106Elevated erythrocyte sedimentation rate (HP:0003565)2.11131372
107Rapidly progressive (HP:0003678)2.09891666
108Apathy (HP:0000741)2.09872437
109Hypsarrhythmia (HP:0002521)2.09618643
110Neoplasm of the adrenal cortex (HP:0100641)2.07276520
111Abnormality of calcium-phosphate metabolism (HP:0100530)2.07266174
112Colitis (HP:0002583)2.06717319
113Type II lissencephaly (HP:0007260)2.06586532
114Hemiplegia (HP:0002301)2.06131228
115Keratoconjunctivitis sicca (HP:0001097)2.05798153
116Dysdiadochokinesis (HP:0002075)2.05780645
117Central scotoma (HP:0000603)2.05548998
118Gastrointestinal inflammation (HP:0004386)2.05232003
119Open mouth (HP:0000194)2.03216987
120Hypoventilation (HP:0002791)2.02696276
121Distal lower limb amyotrophy (HP:0008944)2.02465657
122Growth hormone excess (HP:0000845)2.02129930
123Gastrointestinal stroma tumor (HP:0100723)2.00821295
124Abnormality of macular pigmentation (HP:0008002)2.00577597
125Pulmonary infiltrates (HP:0002113)1.99609714
126Insomnia (HP:0100785)1.97910060
127Intention tremor (HP:0002080)1.97442682
128Difficulty climbing stairs (HP:0003551)1.97329800
129Tented upper lip vermilion (HP:0010804)1.97232472
130Recurrent skin infections (HP:0001581)1.96776960
131Cerebral inclusion bodies (HP:0100314)1.95946101
132Abnormality of binocular vision (HP:0011514)1.95436828
133Diplopia (HP:0000651)1.95436828
134Neuronal loss in central nervous system (HP:0002529)1.94312760
135Neurofibrillary tangles (HP:0002185)1.94022689
136Vasculitis (HP:0002633)1.94015347
137* Lower limb muscle weakness (HP:0007340)1.93364463
138Gastrointestinal infarctions (HP:0005244)1.92765338
139Malnutrition (HP:0004395)1.92282110
140Lower limb amyotrophy (HP:0007210)1.91964193
141Amyotrophic lateral sclerosis (HP:0007354)1.91604618
142Fetal akinesia sequence (HP:0001989)1.91239574
143Hyperacusis (HP:0010780)1.90864558
144Polyphagia (HP:0002591)1.90276547
145Exotropia (HP:0000577)1.90263863
146Inflammation of the large intestine (HP:0002037)1.90242613
147Upper motor neuron abnormality (HP:0002127)1.86782221
148Gait imbalance (HP:0002141)1.86075587
149Encephalitis (HP:0002383)1.85862670
150Amyloidosis (HP:0011034)1.85496278
151Anosmia (HP:0000458)1.84948902
152Abnormality of ocular smooth pursuit (HP:0000617)1.84703836
153Abnormality of salivation (HP:0100755)1.84630454
154Hemiparesis (HP:0001269)1.83382871
155Emphysema (HP:0002097)1.83093320
156Increased serum ferritin (HP:0003281)1.82818584
157Neuroendocrine neoplasm (HP:0100634)1.82220461
158Cholecystitis (HP:0001082)1.81133896
159Abnormal gallbladder physiology (HP:0012438)1.81133896
160Segmental peripheral demyelination/remyelination (HP:0003481)1.81094763
161Bradycardia (HP:0001662)1.80864796
162Rigidity (HP:0002063)1.80072555
163Panhypogammaglobulinemia (HP:0003139)1.79839595
164Prolonged bleeding time (HP:0003010)1.78998090
165Urticaria (HP:0001025)1.78365152
166Diminished motivation (HP:0000745)1.78210421
167Blue irides (HP:0000635)1.78134502
168Stomatitis (HP:0010280)1.78077043
169Progressive neurologic deterioration (HP:0002344)1.77069023
170Ventricular fibrillation (HP:0001663)1.75770589
171Iris hypopigmentation (HP:0007730)1.74632420
172Hemoptysis (HP:0002105)1.74438710
173Chest pain (HP:0100749)1.73428876
174Hyperparathyroidism (HP:0000843)1.73205270
175Ragged-red muscle fibers (HP:0003200)1.73135869
176Hypercortisolism (HP:0001578)1.72822759
177Premature loss of primary teeth (HP:0006323)1.72354645
178Petechiae (HP:0000967)1.71850224
179Systemic lupus erythematosus (HP:0002725)1.71736507
180Episodic fever (HP:0001954)1.71302291
181Keratoconjunctivitis (HP:0001096)1.70217566
182Ocular albinism (HP:0001107)1.69770375
183Deep palmar crease (HP:0006191)1.69625580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.74216855
2CASK3.46048660
3MARK13.05829705
4ERN12.98146214
5MAP3K92.95460232
6TRIB32.79720618
7DAPK22.67724594
8MAP3K42.60237269
9PRPF4B2.45080574
10MAP4K12.44793193
11EPHA42.39272794
12MINK12.27112693
13MAP2K72.23853918
14MAP3K112.16164350
15NTRK22.01872548
16NTRK11.85477494
17FES1.82700172
18PAK61.80887678
19TESK21.77718436
20ICK1.71028148
21TAOK11.68677737
22SIK21.66874724
23IRAK41.66831333
24SMG11.66451618
25TNIK1.66037875
26MAP3K61.65188159
27MAP2K31.64906201
28MAPK131.63629990
29MAP3K121.61434329
30BLK1.59438277
31SIK11.56079091
32RIPK41.46541846
33SGK2231.46446295
34SGK4941.46446295
35EPHA31.43459279
36GRK61.40648685
37CDK51.40316595
38CAMKK21.38948706
39MAP2K41.38225185
40SGK21.37475478
41TAOK21.36339395
42UHMK11.36091817
43MAP3K131.33903280
44DAPK11.31434704
45IRAK31.30672077
46CAMKK11.30151447
47ZAP701.26651309
48PIM21.25742170
49TYK21.25408043
50KSR11.19982443
51FGFR41.18164722
52ARAF1.17711776
53CDK191.17638313
54AKT31.17097044
55TBK11.14269661
56KSR21.12949484
57SGK31.11397064
58SIK31.11028496
59CAMK1G1.10551840
60PRKCH1.07751190
61PNCK1.06570228
62CSNK1G21.05987907
63IRAK21.04903994
64MAP3K21.04710807
65RPS6KA21.04672104
66PRKD21.02826877
67CSK1.02023944
68CAMK11.00376161
69PRKD30.97649952
70MAP3K30.96991983
71OXSR10.96593080
72TESK10.96315676
73TNK20.95594083
74DYRK1B0.95206854
75MARK20.93066570
76JAK20.92390484
77IKBKE0.91142512
78GRK50.90130453
79BTK0.89207105
80RET0.87472433
81CSNK1A1L0.87166968
82PRKCG0.86041241
83CDK120.85276584
84HCK0.82572362
85MAP3K10.80591918
86JAK30.79315022
87CSNK1G30.77880144
88LMTK20.77691336
89FER0.77572724
90MAPK120.77036372
91MAP3K50.75947288
92EPHB10.75657129
93PHKG10.73521688
94PHKG20.73521688
95CDC42BPA0.73328125
96CAMK2B0.73202901
97SGK10.72476153
98PKN20.72209908
99CAMK2A0.70659389
100PAK30.68057164
101PRKCE0.68038676
102MAP2K60.67376565
103WNK10.66928551
104HIPK20.66017607
105STK110.65316043
106PTK60.65283773
107DYRK1A0.63957626
108CCNB10.63532331
109MATK0.63018891
110WNK30.62657544
111STK380.62089001
112PLK20.61195807
113CDK180.60797467
114TYRO30.60331668
115FGFR30.57609590
116CDK150.56333518
117FGR0.55664732
118MAP3K70.54956803
119BRD40.52936775
120LYN0.52865908
121FYN0.52856306
122MAP3K140.52247045
123CAMK2G0.52116139
124JAK10.50719395
125EEF2K0.50602032
126LCK0.50371575
127ITK0.50232765
128CAMK2D0.49680131
129NEK60.49253236
130PDK10.48097667
131CDK11A0.47771238
132CDK140.46892190
133RAF10.44726226
134ERBB30.42314087
135MAPK110.42249968
136IKBKB0.41961870
137PDPK10.41198585
138CAMK40.41169629
139RPS6KC10.41023516
140RPS6KL10.41023516
141MAPK40.40785702
142INSRR0.40444772
143RPS6KB10.39921207
144RIPK10.38736419
145RPS6KA30.38592469
146ALK0.38088912
147MAPK150.37687074
148SYK0.37460162
149PRKCZ0.37017201
150MAPK80.36793855

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.35522484
2Nicotine addiction_Homo sapiens_hsa050332.95036105
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.93624579
4Other glycan degradation_Homo sapiens_hsa005112.45585104
5Circadian entrainment_Homo sapiens_hsa047132.41596982
6Olfactory transduction_Homo sapiens_hsa047402.41243746
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33370163
8GABAergic synapse_Homo sapiens_hsa047272.23560200
9Morphine addiction_Homo sapiens_hsa050322.19922182
10Glutamatergic synapse_Homo sapiens_hsa047242.17279544
11Long-term potentiation_Homo sapiens_hsa047202.13999799
12Insulin secretion_Homo sapiens_hsa049112.11897890
13Dopaminergic synapse_Homo sapiens_hsa047281.99054228
14Osteoclast differentiation_Homo sapiens_hsa043801.97177160
15Amphetamine addiction_Homo sapiens_hsa050311.95756795
16Taste transduction_Homo sapiens_hsa047421.87736258
17Salivary secretion_Homo sapiens_hsa049701.83840234
18Cholinergic synapse_Homo sapiens_hsa047251.82901386
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78497627
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.71748072
21Collecting duct acid secretion_Homo sapiens_hsa049661.66149562
22Phototransduction_Homo sapiens_hsa047441.64175817
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61854219
24Leishmaniasis_Homo sapiens_hsa051401.59492333
25Acute myeloid leukemia_Homo sapiens_hsa052211.59149201
26Cocaine addiction_Homo sapiens_hsa050301.57217626
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.55558672
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53739944
29Gastric acid secretion_Homo sapiens_hsa049711.52515422
30Serotonergic synapse_Homo sapiens_hsa047261.52380619
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.49584286
32Renin secretion_Homo sapiens_hsa049241.44597239
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40367985
34Long-term depression_Homo sapiens_hsa047301.39374455
35Type II diabetes mellitus_Homo sapiens_hsa049301.37064494
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32010403
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31410578
38Calcium signaling pathway_Homo sapiens_hsa040201.27989135
39Oxytocin signaling pathway_Homo sapiens_hsa049211.27699318
40Vibrio cholerae infection_Homo sapiens_hsa051101.25336008
41Fructose and mannose metabolism_Homo sapiens_hsa000511.24335163
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22297437
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18482746
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17707905
45Salmonella infection_Homo sapiens_hsa051321.17155448
46GnRH signaling pathway_Homo sapiens_hsa049121.15893716
47Hepatitis C_Homo sapiens_hsa051601.15520606
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14726127
49cAMP signaling pathway_Homo sapiens_hsa040241.14496150
50Chronic myeloid leukemia_Homo sapiens_hsa052201.14280838
51Notch signaling pathway_Homo sapiens_hsa043301.13702392
52ErbB signaling pathway_Homo sapiens_hsa040121.11889854
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11808959
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11338814
55Primary immunodeficiency_Homo sapiens_hsa053401.10924283
56Axon guidance_Homo sapiens_hsa043601.09412399
57Shigellosis_Homo sapiens_hsa051311.07570317
58TNF signaling pathway_Homo sapiens_hsa046681.05951794
59Gap junction_Homo sapiens_hsa045401.05681219
60Staphylococcus aureus infection_Homo sapiens_hsa051501.04597400
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02127930
62Glioma_Homo sapiens_hsa052141.01427031
63Estrogen signaling pathway_Homo sapiens_hsa049150.99419959
64Hepatitis B_Homo sapiens_hsa051610.96231331
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95702159
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93990608
67Toxoplasmosis_Homo sapiens_hsa051450.93716075
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.93695186
69Pancreatic secretion_Homo sapiens_hsa049720.92836758
70Inositol phosphate metabolism_Homo sapiens_hsa005620.92546024
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89732935
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.89410666
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88020260
74Influenza A_Homo sapiens_hsa051640.87931988
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.87000676
76Apoptosis_Homo sapiens_hsa042100.85326623
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.84712268
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84381070
79MAPK signaling pathway_Homo sapiens_hsa040100.81702629
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.80211309
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79575671
82Pancreatic cancer_Homo sapiens_hsa052120.79354991
83Dorso-ventral axis formation_Homo sapiens_hsa043200.79249025
84mTOR signaling pathway_Homo sapiens_hsa041500.79155533
85Galactose metabolism_Homo sapiens_hsa000520.78242626
86Endometrial cancer_Homo sapiens_hsa052130.78038980
87Herpes simplex infection_Homo sapiens_hsa051680.77838887
88Pertussis_Homo sapiens_hsa051330.76410065
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76067497
90Prion diseases_Homo sapiens_hsa050200.74409815
91Melanogenesis_Homo sapiens_hsa049160.74122434
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73637489
93Thyroid hormone synthesis_Homo sapiens_hsa049180.73533411
94Allograft rejection_Homo sapiens_hsa053300.72216371
95Chemokine signaling pathway_Homo sapiens_hsa040620.71529776
96Malaria_Homo sapiens_hsa051440.71401504
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.71125348
98Measles_Homo sapiens_hsa051620.70302944
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70181274
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69832867
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67957773
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67917719
103Graft-versus-host disease_Homo sapiens_hsa053320.67337147
104Choline metabolism in cancer_Homo sapiens_hsa052310.66801604
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.65606678
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65356251
107Circadian rhythm_Homo sapiens_hsa047100.63332919
108Bladder cancer_Homo sapiens_hsa052190.62862172
109Ras signaling pathway_Homo sapiens_hsa040140.62845601
110* Endocytosis_Homo sapiens_hsa041440.61069976
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.60916994
112Lysosome_Homo sapiens_hsa041420.60389612
113Autoimmune thyroid disease_Homo sapiens_hsa053200.59921291
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59642586
115AMPK signaling pathway_Homo sapiens_hsa041520.59462336
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59301869
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.58708476
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58580966
119Rap1 signaling pathway_Homo sapiens_hsa040150.57632974
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56197204
121Viral myocarditis_Homo sapiens_hsa054160.55302602
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55278424
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52443517
124VEGF signaling pathway_Homo sapiens_hsa043700.52215076
125Non-small cell lung cancer_Homo sapiens_hsa052230.51761439
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51171393
127Platelet activation_Homo sapiens_hsa046110.49964599
128Glucagon signaling pathway_Homo sapiens_hsa049220.49927844
129Prolactin signaling pathway_Homo sapiens_hsa049170.49686009
130Renal cell carcinoma_Homo sapiens_hsa052110.49538362
131Rheumatoid arthritis_Homo sapiens_hsa053230.47699405
132Insulin signaling pathway_Homo sapiens_hsa049100.47450187
133Dilated cardiomyopathy_Homo sapiens_hsa054140.47088609
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47029849
135N-Glycan biosynthesis_Homo sapiens_hsa005100.46261500
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45174851
137Phagosome_Homo sapiens_hsa041450.44758723
138T cell receptor signaling pathway_Homo sapiens_hsa046600.41183675
139Type I diabetes mellitus_Homo sapiens_hsa049400.40354704
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40336283
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39494610
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.39326724
143Colorectal cancer_Homo sapiens_hsa052100.37819551
144B cell receptor signaling pathway_Homo sapiens_hsa046620.35715650
145Alcoholism_Homo sapiens_hsa050340.33517388
146Wnt signaling pathway_Homo sapiens_hsa043100.33360699
147Regulation of autophagy_Homo sapiens_hsa041400.33312072
148Tuberculosis_Homo sapiens_hsa051520.33283279

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