ZFYVE28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.39216480
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.26178071
3neuronal action potential propagation (GO:0019227)5.04449671
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.85311639
5vocalization behavior (GO:0071625)4.81339917
6ionotropic glutamate receptor signaling pathway (GO:0035235)4.74225131
7locomotory exploration behavior (GO:0035641)4.69621679
8synaptic vesicle maturation (GO:0016188)4.61194685
9synaptic vesicle exocytosis (GO:0016079)4.53960195
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.53229897
11glutamate receptor signaling pathway (GO:0007215)4.38969464
12protein localization to synapse (GO:0035418)4.38862411
13neuron cell-cell adhesion (GO:0007158)4.37831362
14regulation of synaptic vesicle exocytosis (GO:2000300)4.32478224
15regulation of glutamate receptor signaling pathway (GO:1900449)4.30900029
16synaptic transmission, glutamatergic (GO:0035249)4.27563328
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.25377540
18glutamate secretion (GO:0014047)4.20133185
19neuron-neuron synaptic transmission (GO:0007270)4.16451337
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.08127025
21neurotransmitter-gated ion channel clustering (GO:0072578)3.96635954
22neurotransmitter secretion (GO:0007269)3.93627867
23transmission of nerve impulse (GO:0019226)3.91673152
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87098472
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.86602547
26regulation of neuronal synaptic plasticity (GO:0048168)3.84879356
27gamma-aminobutyric acid transport (GO:0015812)3.83883542
28regulation of synaptic vesicle transport (GO:1902803)3.83114646
29regulation of excitatory postsynaptic membrane potential (GO:0060079)3.82154823
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.81548727
31cerebellar Purkinje cell differentiation (GO:0021702)3.80351548
32G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.75217486
33long-term memory (GO:0007616)3.72893151
34negative regulation of cell killing (GO:0031342)3.72345215
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.72345215
36negative regulation of synaptic transmission, GABAergic (GO:0032229)3.66722622
37regulation of postsynaptic membrane potential (GO:0060078)3.61497785
38regulation of synapse structural plasticity (GO:0051823)3.59548487
39regulation of synaptic transmission, glutamatergic (GO:0051966)3.57330689
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.57266814
41membrane depolarization during action potential (GO:0086010)3.57169207
42exploration behavior (GO:0035640)3.55181468
43regulation of neurotransmitter secretion (GO:0046928)3.52791818
44positive regulation of membrane potential (GO:0045838)3.52603834
45negative regulation of erythrocyte differentiation (GO:0045647)3.48017481
46regulation of ARF protein signal transduction (GO:0032012)3.47701255
47negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.47026066
48cellular potassium ion homeostasis (GO:0030007)3.46386196
49presynaptic membrane assembly (GO:0097105)3.45172414
50long-term synaptic potentiation (GO:0060291)3.44182124
51negative regulation of dendrite morphogenesis (GO:0050774)3.43572565
52auditory behavior (GO:0031223)3.42785563
53response to auditory stimulus (GO:0010996)3.41848226
54presynaptic membrane organization (GO:0097090)3.38898794
55sodium ion export (GO:0071436)3.37193904
56membrane depolarization (GO:0051899)3.36602448
57membrane hyperpolarization (GO:0060081)3.36413164
58positive regulation of neurotransmitter transport (GO:0051590)3.34773899
59positive regulation of synaptic transmission, GABAergic (GO:0032230)3.34409490
60negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.34394379
61neurotransmitter transport (GO:0006836)3.32405148
62prepulse inhibition (GO:0060134)3.32135072
63regulation of neurotransmitter transport (GO:0051588)3.31692058
64positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.31630677
65signal complex assembly (GO:0007172)3.31537762
66regulation of synaptic plasticity (GO:0048167)3.31115172
67synaptic vesicle endocytosis (GO:0048488)3.29488898
68regulation of voltage-gated calcium channel activity (GO:1901385)3.29263451
69positive regulation of neurotransmitter secretion (GO:0001956)3.24604870
70macrophage activation involved in immune response (GO:0002281)3.24523284
71striatum development (GO:0021756)3.24198580
72negative regulation of dendrite development (GO:2000171)3.20849411
73neuronal action potential (GO:0019228)3.20541779
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.20256099
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.19314297
76postsynaptic membrane organization (GO:0001941)3.19038631
77cerebellar granule cell differentiation (GO:0021707)3.18482809
78regulation of vesicle fusion (GO:0031338)3.17594989
79negative regulation of interleukin-12 production (GO:0032695)3.16927243
80adult walking behavior (GO:0007628)3.13877020
81learning (GO:0007612)3.13871813
82positive regulation of gamma-delta T cell activation (GO:0046645)3.12775772
83mechanosensory behavior (GO:0007638)3.12029030
84regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10214882
85behavioral response to cocaine (GO:0048148)3.09945197
86neuromuscular process controlling balance (GO:0050885)3.09415649
87positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06426172
88synaptic transmission, dopaminergic (GO:0001963)3.06169710
89dendritic spine morphogenesis (GO:0060997)3.06063862
90mannose metabolic process (GO:0006013)3.03605537
91lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03029110
92synapse assembly (GO:0007416)3.02619083
93neuron recognition (GO:0008038)3.02202982
94L-amino acid import (GO:0043092)3.01995679
95regulation of dendritic spine morphogenesis (GO:0061001)3.01420016
96regulation of neurotransmitter levels (GO:0001505)3.00701258
97neuromuscular process controlling posture (GO:0050884)2.99678233
98glycine transport (GO:0015816)2.98935262
99positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.98740993
100synaptic transmission (GO:0007268)2.98336845
101regulation of T-helper 2 cell differentiation (GO:0045628)2.96920072
102neuronal ion channel clustering (GO:0045161)2.96065975
103response to amphetamine (GO:0001975)2.95792755
104response to histamine (GO:0034776)2.95357628
105positive regulation of synapse maturation (GO:0090129)2.94823419
106regulation of synapse maturation (GO:0090128)2.92710572
107regulation of respiratory system process (GO:0044065)2.92126352
108positive regulation of synaptic transmission (GO:0050806)2.91611366
109behavioral fear response (GO:0001662)2.90978883
110behavioral defense response (GO:0002209)2.90978883
111behavioral response to ethanol (GO:0048149)2.90213011
112regulation of synaptic transmission, GABAergic (GO:0032228)2.89942355
113NIK/NF-kappaB signaling (GO:0038061)2.89876236
114proline transport (GO:0015824)2.89619032
115fear response (GO:0042596)2.87841805
116antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.87659604
117positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.84464047
118germinal center formation (GO:0002467)2.82163590
119positive regulation of Rap GTPase activity (GO:0032854)2.81669628
120protein localization to endosome (GO:0036010)2.79364258
121activation of MAPKKK activity (GO:0000185)2.73599667
122antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70748570
123myeloid dendritic cell differentiation (GO:0043011)2.64024176
124response to peptidoglycan (GO:0032494)2.59741263
125cellular response to thyroid hormone stimulus (GO:0097067)2.58636064
126negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.58227886
127regulation of ARF GTPase activity (GO:0032312)2.57691697
128type I interferon signaling pathway (GO:0060337)2.56545806
129cellular response to type I interferon (GO:0071357)2.56545806
130response to type I interferon (GO:0034340)2.55478741
131positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54742025
132regulation of T cell tolerance induction (GO:0002664)2.48943053
133regulation of vitamin D biosynthetic process (GO:0060556)2.48706188
134positive thymic T cell selection (GO:0045059)2.45803312
135leukocyte aggregation (GO:0070486)2.45166481
136modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.44766181
137positive regulation by organism of defense response of other organism involved in symbiotic interact2.44766181
138modulation by symbiont of host immune response (GO:0052553)2.44766181
139positive regulation by symbiont of host defense response (GO:0052509)2.44766181
140modulation by symbiont of host defense response (GO:0052031)2.44766181
141modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.44766181
142interferon-gamma-mediated signaling pathway (GO:0060333)2.44611773
143regulation of early endosome to late endosome transport (GO:2000641)2.44171440
144antigen processing and presentation of endogenous antigen (GO:0019883)2.43954736
145regulation of gamma-delta T cell activation (GO:0046643)2.43083299
146cytoskeletal anchoring at plasma membrane (GO:0007016)2.42848179
147glycosphingolipid catabolic process (GO:0046479)2.41981037
148negative regulation of cytokine production involved in immune response (GO:0002719)2.41826380
149positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.41364381
150positive regulation of protein dephosphorylation (GO:0035307)2.39570077
151adenosine receptor signaling pathway (GO:0001973)2.36354231
152neutrophil activation involved in immune response (GO:0002283)2.35520687
153T cell migration (GO:0072678)2.33802723
154amino acid import (GO:0043090)2.33428488
155regulation of Rap GTPase activity (GO:0032317)2.33345812
156response to manganese ion (GO:0010042)2.33192502
157response to acidic pH (GO:0010447)2.29569083
158thymic T cell selection (GO:0045061)2.27028911
159regulation of regulated secretory pathway (GO:1903305)2.22783707
160response to muramyl dipeptide (GO:0032495)2.22292693
161regulation of type 2 immune response (GO:0002828)2.22076078
162myeloid cell activation involved in immune response (GO:0002275)2.20321325
163positive regulation of chemokine biosynthetic process (GO:0045080)2.20152685
164negative regulation of type 2 immune response (GO:0002829)2.20063073
165glycolipid catabolic process (GO:0019377)2.19343365
166positive regulation of cellular amide metabolic process (GO:0034250)2.19142671
167regulation of interferon-beta biosynthetic process (GO:0045357)2.19142115
168regulation of leukocyte degranulation (GO:0043300)2.17215951
169T cell selection (GO:0045058)2.17010617
170positive regulation of type 2 immune response (GO:0002830)2.16944373
171regulation of T-helper 1 cell differentiation (GO:0045625)2.15572013
172regulation of chronic inflammatory response (GO:0002676)2.14569104
173negative regulation of amino acid transport (GO:0051956)2.14259021
174positive T cell selection (GO:0043368)2.12021825
175myeloid dendritic cell activation (GO:0001773)2.11764483
176regulation of membrane protein ectodomain proteolysis (GO:0051043)2.11561059
177adhesion of symbiont to host cell (GO:0044650)2.11126719
178virion attachment to host cell (GO:0019062)2.11126719
179negative regulation of leukocyte mediated immunity (GO:0002704)2.10026413
180regulation of interleukin-2 biosynthetic process (GO:0045076)2.09805195

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.37330812
2GBX2_23144817_ChIP-Seq_PC3_Human3.91969586
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.30604343
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05039052
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03512840
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96153595
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65432796
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65432796
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60203718
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55404433
11LXR_22292898_ChIP-Seq_THP-1_Human2.52808326
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.52176053
13REST_21632747_ChIP-Seq_MESCs_Mouse2.49026123
14* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.48273130
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48070356
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.42219068
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38726955
18* DROSHA_22980978_ChIP-Seq_HELA_Human2.34787251
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.33536565
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33127959
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32507668
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.29862851
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28945853
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.23485440
25* RARB_27405468_Chip-Seq_BRAIN_Mouse2.16985471
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16071184
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.15919194
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05259560
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01248235
30TAF15_26573619_Chip-Seq_HEK293_Human1.99404667
31* KDM2B_26808549_Chip-Seq_K562_Human1.97151440
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96955038
33* KDM2B_26808549_Chip-Seq_DND41_Human1.96570478
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90563323
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89602113
36* REST_18959480_ChIP-ChIP_MESCs_Mouse1.89181625
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89179099
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.88889680
39VDR_21846776_ChIP-Seq_THP-1_Human1.88421383
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.88073654
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85775729
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.85689175
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.85336415
44* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85296987
45TCF7_22412390_ChIP-Seq_EML_Mouse1.83992858
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82168170
47AR_21572438_ChIP-Seq_LNCaP_Human1.81015766
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77992912
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75996569
50* ELK3_25401928_ChIP-Seq_HUVEC_Human1.73609310
51SMAD4_21799915_ChIP-Seq_A2780_Human1.73219318
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70300847
53SPI1_23127762_ChIP-Seq_K562_Human1.69657387
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69131036
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69100800
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68712135
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68493353
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68390888
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67270749
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65892571
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65842900
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.65010776
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64424772
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63485598
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.62346836
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61861586
67VDR_24763502_ChIP-Seq_THP-1_Human1.60202600
68P300_19829295_ChIP-Seq_ESCs_Human1.57058268
69* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56857211
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50978544
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50974090
72RACK7_27058665_Chip-Seq_MCF-7_Human1.49834497
73* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48900512
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.48066855
75MAF_26560356_Chip-Seq_TH1_Human1.47492170
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46421180
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46324609
78* RUNX_20019798_ChIP-Seq_JUKART_Human1.43822346
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40913359
80* KDM2B_26808549_Chip-Seq_JURKAT_Human1.40843372
81* GATA1_19941826_ChIP-Seq_K562_Human1.40730188
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40244578
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38081563
84RNF2_27304074_Chip-Seq_NSC_Mouse1.37471615
85* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37241995
86BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37083932
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.37048003
88* GATA1_19941827_ChIP-Seq_MEL_Mouse1.34886840
89SMC4_20622854_ChIP-Seq_HELA_Human1.33817155
90STAT3_23295773_ChIP-Seq_U87_Human1.33238392
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33222404
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32472785
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31814335
94SCL_19346495_ChIP-Seq_HPC-7_Human1.31765160
95P53_22127205_ChIP-Seq_FIBROBLAST_Human1.31537423
96RUNX1_22412390_ChIP-Seq_EML_Mouse1.31347802
97* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30590239
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29961308
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.29091228
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27796217
101P68_20966046_ChIP-Seq_HELA_Human1.27520692
102CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27237698
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27002599
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26236404
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26070412
106FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25194904
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.25054578
108* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24256794
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23708525
110ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23082374
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.23004321
112VDR_22108803_ChIP-Seq_LS180_Human1.22917338
113MAF_26560356_Chip-Seq_TH2_Human1.22579409
114AR_25329375_ChIP-Seq_VCAP_Human1.21324890
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20866791
116* TCF4_23295773_ChIP-Seq_U87_Human1.20419430
117MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19343923
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.17929461
119MYC_22102868_ChIP-Seq_BL_Human1.17714335
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17599320
121PIAS1_25552417_ChIP-Seq_VCAP_Human1.17577820
122EGR1_19374776_ChIP-ChIP_THP-1_Human1.16575345
123SOX2_21211035_ChIP-Seq_LN229_Gbm1.16381054
124CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15655185
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15596323
126UTX_26944678_Chip-Seq_JUKART_Human1.15354148
127VDR_24787735_ChIP-Seq_THP-1_Human1.13830292
128RING1B_27294783_Chip-Seq_ESCs_Mouse1.13438875
129BCOR_27268052_Chip-Seq_Bcells_Human1.13353003
130IGF1R_20145208_ChIP-Seq_DFB_Human1.13094689
131* AR_19668381_ChIP-Seq_PC3_Human1.12876994
132FLI1_27457419_Chip-Seq_LIVER_Mouse1.11577428
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11255100
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11255100
135CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10692967
136GATA2_21666600_ChIP-Seq_HMVEC_Human1.10128633
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09744636
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09728350
139ELF1_20517297_ChIP-Seq_JURKAT_Human1.09718745
140* RUNX2_22187159_ChIP-Seq_PCA_Human1.09532276
141RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09375428
142PRDM14_20953172_ChIP-Seq_ESCs_Human1.09065104
143FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09010203
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08924699
145P53_22387025_ChIP-Seq_ESCs_Mouse1.08567077
146UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08510254
147EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08313976
148PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07568590
149CMYC_18555785_Chip-Seq_ESCs_Mouse1.07399749
150UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07115878
151AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06570218
152CREB1_26743006_Chip-Seq_LNCaP_Human1.06298225
153AHR_22903824_ChIP-Seq_MCF-7_Human1.06297057
154ARNT_22903824_ChIP-Seq_MCF-7_Human1.06144451
155BCL6_27268052_Chip-Seq_Bcells_Human1.05207768
156RING1B_27294783_Chip-Seq_NPCs_Mouse1.04464472
157MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04429180
158NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02753303
159GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02636870
160ER_23166858_ChIP-Seq_MCF-7_Human1.02633952
161STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02143680
162TP53_16413492_ChIP-PET_HCT116_Human1.01915462
163CTCF_27219007_Chip-Seq_Bcells_Human1.01486988
164LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01237129
165SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00864880
166FUS_26573619_Chip-Seq_HEK293_Human1.00593343
167VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00545948
168TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98854898
169SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98645430
170* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98304475
171WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97888260
172NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97806520
173ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97423141
174SA1_27219007_Chip-Seq_Bcells_Human0.97367291
175CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97321874
176P300_18555785_Chip-Seq_ESCs_Mouse0.96704890
177PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95858183
178* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95830908
179EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95430249
180SMAD3_21741376_ChIP-Seq_HESCs_Human0.95121298
181CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95051323
182ESR1_21235772_ChIP-Seq_MCF-7_Human0.95046749
183TET1_21451524_ChIP-Seq_MESCs_Mouse0.95000907
184OCT4_19829295_ChIP-Seq_ESCs_Human0.94750370
185RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94584467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.29192820
2MP0003880_abnormal_central_pattern4.33761838
3MP0003303_peritoneal_inflammation3.78572538
4MP0003635_abnormal_synaptic_transmissio3.72202016
5MP0002822_catalepsy3.68482859
6MP0001968_abnormal_touch/_nociception3.56424722
7MP0004270_analgesia3.46758765
8MP0009046_muscle_twitch3.42876900
9MP0009745_abnormal_behavioral_response3.37672938
10MP0005423_abnormal_somatic_nervous3.15132297
11MP0005058_abnormal_lysosome_morphology3.08351707
12MP0002063_abnormal_learning/memory/cond2.98311721
13MP0002064_seizures2.98123404
14MP0006082_CNS_inflammation2.96817597
15MP0002736_abnormal_nociception_after2.95771442
16MP0003436_decreased_susceptibility_to2.95486942
17MP0002735_abnormal_chemical_nociception2.84570982
18MP0002272_abnormal_nervous_system2.83597537
19MP0002734_abnormal_mechanical_nocicepti2.83290955
20MP0001486_abnormal_startle_reflex2.79399549
21MP0002572_abnormal_emotion/affect_behav2.71825907
22MP0003172_abnormal_lysosome_physiology2.60885759
23MP0003724_increased_susceptibility_to2.36452767
24MP0009840_abnormal_foam_cell2.30364697
25MP0003075_altered_response_to2.20923755
26MP0002067_abnormal_sensory_capabilities2.20895759
27MP0001501_abnormal_sleep_pattern2.18762302
28MP0005671_abnormal_response_to2.15888309
29MP0001970_abnormal_pain_threshold2.15507840
30MP0000604_amyloidosis2.14534367
31MP0002733_abnormal_thermal_nociception2.12956427
32MP0001188_hyperpigmentation2.08856466
33MP0005000_abnormal_immune_tolerance2.08281916
34MP0003300_gastrointestinal_ulcer2.07287650
35MP0002148_abnormal_hypersensitivity_rea1.98893508
36MP0001440_abnormal_grooming_behavior1.97317478
37MP0008569_lethality_at_weaning1.96482380
38MP0002419_abnormal_innate_immunity1.91161091
39MP0001790_abnormal_immune_system1.89616531
40MP0005387_immune_system_phenotype1.89616531
41MP0002184_abnormal_innervation1.88594162
42MP0009785_altered_susceptibility_to1.85541855
43MP0004947_skin_inflammation1.85505060
44MP0001984_abnormal_olfaction1.85492339
45MP0001835_abnormal_antigen_presentation1.83942495
46MP0005025_abnormal_response_to1.83246921
47MP0006276_abnormal_autonomic_nervous1.78621011
48MP0005451_abnormal_body_composition1.78125525
49MP0005646_abnormal_pituitary_gland1.77265438
50MP0002557_abnormal_social/conspecific_i1.76811413
51MP0003191_abnormal_cellular_cholesterol1.69940518
52MP0003787_abnormal_imprinting1.69150855
53MP0005386_behavior/neurological_phenoty1.64237435
54MP0004924_abnormal_behavior1.64237435
55MP0005551_abnormal_eye_electrophysiolog1.61354673
56MP0001533_abnormal_skeleton_physiology1.60231072
57MP0002723_abnormal_immune_serum1.60029191
58MP0000778_abnormal_nervous_system1.59318070
59MP0005166_decreased_susceptibility_to1.58237620
60MP0001800_abnormal_humoral_immune1.53000393
61MP0001529_abnormal_vocalization1.52387572
62MP0005645_abnormal_hypothalamus_physiol1.50284909
63MP0004142_abnormal_muscle_tone1.49082768
64MP0004742_abnormal_vestibular_system1.48644057
65MP0004811_abnormal_neuron_physiology1.47337503
66MP0001986_abnormal_taste_sensitivity1.46842879
67MP0002452_abnormal_antigen_presenting1.46494108
68MP0002998_abnormal_bone_remodeling1.46135615
69MP0009333_abnormal_splenocyte_physiolog1.45677849
70MP0000569_abnormal_digit_pigmentation1.44094982
71MP0003879_abnormal_hair_cell1.43782117
72MP0005409_darkened_coat_color1.43540281
73MP0002882_abnormal_neuron_morphology1.42106668
74MP0000955_abnormal_spinal_cord1.41895533
75MP0010155_abnormal_intestine_physiology1.41266427
76MP0004858_abnormal_nervous_system1.41189883
77MP0002420_abnormal_adaptive_immunity1.39647418
78MP0001819_abnormal_immune_cell1.38615574
79MP0001905_abnormal_dopamine_level1.37652087
80MP0002638_abnormal_pupillary_reflex1.36835407
81MP0003763_abnormal_thymus_physiology1.35411012
82MP0002066_abnormal_motor_capabilities/c1.32794236
83MP0006292_abnormal_olfactory_placode1.29935802
84MP0003453_abnormal_keratinocyte_physiol1.29203242
85MP0005310_abnormal_salivary_gland1.28730531
86MP0000343_altered_response_to1.28288854
87MP0001502_abnormal_circadian_rhythm1.26918254
88MP0009278_abnormal_bone_marrow1.25553175
89MP0000685_abnormal_immune_system1.22626512
90MP0001845_abnormal_inflammatory_respons1.22604908
91MP0001348_abnormal_lacrimal_gland1.21834796
92MP0003633_abnormal_nervous_system1.20840985
93MP0004885_abnormal_endolymph1.19778292
94MP0002405_respiratory_system_inflammati1.18660446
95MP0005171_absent_coat_pigmentation1.14537484
96MP0010386_abnormal_urinary_bladder1.14439298
97MP0002229_neurodegeneration1.13781421
98MP0002332_abnormal_exercise_endurance1.10839488
99MP0001873_stomach_inflammation1.09059977
100MP0008004_abnormal_stomach_pH1.08868974
101MP0001963_abnormal_hearing_physiology1.08539816
102MP0003045_fibrosis1.08261502
103MP0002139_abnormal_hepatobiliary_system1.08157769
104MP0008872_abnormal_physiological_respon1.08112178
105MP0009764_decreased_sensitivity_to1.07565584
106MP0004145_abnormal_muscle_electrophysio1.04769743
107MP0001853_heart_inflammation1.04615665
108MP0003631_nervous_system_phenotype1.04338679
109MP0002752_abnormal_somatic_nervous1.03505485
110MP0008469_abnormal_protein_level1.03062878
111MP0002909_abnormal_adrenal_gland1.02234808
112MP0003136_yellow_coat_color1.01748503
113MP0003448_altered_tumor_morphology1.00897220
114MP0001485_abnormal_pinna_reflex1.00776295
115MP0000716_abnormal_immune_system0.97937182
116MP0005499_abnormal_olfactory_system0.97766958
117MP0005394_taste/olfaction_phenotype0.97766958
118MP0000920_abnormal_myelination0.97544563
119MP0000015_abnormal_ear_pigmentation0.96086858
120MP0002152_abnormal_brain_morphology0.95722187
121MP0009780_abnormal_chondrocyte_physiolo0.95326230
122MP0003866_abnormal_defecation0.92826045
123MP0001851_eye_inflammation0.91318915
124MP0005464_abnormal_platelet_physiology0.90983424
125MP0003091_abnormal_cell_migration0.89869514
126MP0005253_abnormal_eye_physiology0.87683985
127MP0002933_joint_inflammation0.86441400
128MP0003329_amyloid_beta_deposits0.85034648
129MP0000858_altered_metastatic_potential0.84285153
130MP0003705_abnormal_hypodermis_morpholog0.83806289
131MP0006072_abnormal_retinal_apoptosis0.82344059
132MP0001545_abnormal_hematopoietic_system0.82028476
133MP0005397_hematopoietic_system_phenotyp0.82028476
134MP0002398_abnormal_bone_marrow0.81790700
135MP0003183_abnormal_peptide_metabolism0.81345224
136MP0001177_atelectasis0.80352518
137MP0008874_decreased_physiological_sensi0.79665139
138MP0005165_increased_susceptibility_to0.79285517
139MP0002069_abnormal_eating/drinking_beha0.79089830
140MP0003690_abnormal_glial_cell0.77218291
141MP0000631_abnormal_neuroendocrine_gland0.76950067
142MP0001849_ear_inflammation0.75433291
143MP0003632_abnormal_nervous_system0.74645650
144MP0000026_abnormal_inner_ear0.74628839
145MP0003634_abnormal_glial_cell0.74163797
146MP0002090_abnormal_vision0.72070647
147MP0001765_abnormal_ion_homeostasis0.71932861
148MP0003279_aneurysm0.71169810
149MP0005666_abnormal_adipose_tissue0.67965941
150MP0004085_abnormal_heartbeat0.67148168
151MP0001663_abnormal_digestive_system0.66401484
152MP0005535_abnormal_body_temperature0.61114132
153MP0002751_abnormal_autonomic_nervous0.60508225
154MP0002876_abnormal_thyroid_physiology0.59977465
155MP0001664_abnormal_digestion0.59323187
156MP0002102_abnormal_ear_morphology0.54273990
157MP0008260_abnormal_autophagy0.53917247
158MP0008877_abnormal_DNA_methylation0.51835938
159MP0003137_abnormal_impulse_conducting0.50437647
160MP0001943_abnormal_respiration0.49607016
161MP0000751_myopathy0.48321140
162MP0005195_abnormal_posterior_eye0.48277669
163MP0005167_abnormal_blood-brain_barrier0.47563275
164MP0004510_myositis0.47321299
165MP0010769_abnormal_survival0.46372745
166MP0004147_increased_porphyrin_level0.46117713
167MP0002082_postnatal_lethality0.45916637
168MP0010770_preweaning_lethality0.45916637

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.67592023
2Myokymia (HP:0002411)6.64265156
3Febrile seizures (HP:0002373)5.62672641
4Focal seizures (HP:0007359)5.57771367
5Epileptic encephalopathy (HP:0200134)4.90014193
6Progressive cerebellar ataxia (HP:0002073)4.78743315
7Action tremor (HP:0002345)4.59552920
8Atonic seizures (HP:0010819)4.49521988
9Abnormality of glycolipid metabolism (HP:0010969)4.48002727
10Abnormality of liposaccharide metabolism (HP:0010968)4.48002727
11Abnormality of glycosphingolipid metabolism (HP:0004343)4.48002727
12Neurofibrillary tangles (HP:0002185)4.32763584
13Gaze-evoked nystagmus (HP:0000640)4.05410363
14Visual hallucinations (HP:0002367)3.94044524
15Broad-based gait (HP:0002136)3.76592195
16Dysostosis multiplex (HP:0000943)3.67972373
17Absence seizures (HP:0002121)3.60849140
18Cerebral inclusion bodies (HP:0100314)3.52879339
19Generalized tonic-clonic seizures (HP:0002069)3.51267992
20Eczematoid dermatitis (HP:0000976)3.48329986
21Dialeptic seizures (HP:0011146)3.46784139
22Neuronal loss in central nervous system (HP:0002529)3.40971151
23Increased cerebral lipofuscin (HP:0011813)3.40678705
24Abnormality of macrophages (HP:0004311)3.36959276
25Loss of speech (HP:0002371)3.31226380
26Obstructive sleep apnea (HP:0002870)3.31111772
27Dysdiadochokinesis (HP:0002075)3.17650064
28Nuclear cataract (HP:0100018)3.12971737
29Systemic lupus erythematosus (HP:0002725)3.02995409
30Scanning speech (HP:0002168)2.96362870
31Congenital stationary night blindness (HP:0007642)2.94057621
32Poor eye contact (HP:0000817)2.93618883
33Axonal loss (HP:0003447)2.89198265
34Dysmetria (HP:0001310)2.88353784
35Abnormality of glycosaminoglycan metabolism (HP:0004371)2.87435710
36Abnormality of mucopolysaccharide metabolism (HP:0011020)2.87435710
37Abnormality of polysaccharide metabolism (HP:0011012)2.87435710
38Mucopolysacchariduria (HP:0008155)2.85753766
39Urinary glycosaminoglycan excretion (HP:0003541)2.85753766
40Hyperventilation (HP:0002883)2.82255359
41Supranuclear gaze palsy (HP:0000605)2.81457181
42Apathy (HP:0000741)2.80605759
43Urinary bladder sphincter dysfunction (HP:0002839)2.79860580
44Myositis (HP:0100614)2.78860891
45Truncal ataxia (HP:0002078)2.77765094
46Recurrent bacterial skin infections (HP:0005406)2.76151554
47Orchitis (HP:0100796)2.74835048
48Slow saccadic eye movements (HP:0000514)2.73635737
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.73533784
50Papilledema (HP:0001085)2.72832479
51Recurrent abscess formation (HP:0002722)2.70728475
52Impaired smooth pursuit (HP:0007772)2.66881128
53Amblyopia (HP:0000646)2.66464664
54Hemiparesis (HP:0001269)2.62806680
55Disinhibition (HP:0000734)2.62389321
56Ulnar claw (HP:0001178)2.61527079
57Impaired vibration sensation in the lower limbs (HP:0002166)2.60737116
58Diminished motivation (HP:0000745)2.60622967
59Ankle clonus (HP:0011448)2.60588946
60Retrobulbar optic neuritis (HP:0100654)2.56892439
61Optic neuritis (HP:0100653)2.56892439
62Anxiety (HP:0000739)2.56511877
63Fetal akinesia sequence (HP:0001989)2.54955872
64Stomatitis (HP:0010280)2.54141175
65Tetraplegia (HP:0002445)2.53505778
66Vacuolated lymphocytes (HP:0001922)2.53038171
67Abnormal eating behavior (HP:0100738)2.48214593
68Abnormality of binocular vision (HP:0011514)2.48075827
69Diplopia (HP:0000651)2.48075827
70Absent speech (HP:0001344)2.46237454
71Depression (HP:0000716)2.42736939
72Absent/shortened dynein arms (HP:0200106)2.41229260
73Dynein arm defect of respiratory motile cilia (HP:0012255)2.41229260
74Abnormal social behavior (HP:0012433)2.39576726
75Impaired social interactions (HP:0000735)2.39576726
76Genetic anticipation (HP:0003743)2.36270422
77Stereotypic behavior (HP:0000733)2.35343912
78Spastic gait (HP:0002064)2.29853645
79Gait imbalance (HP:0002141)2.29478493
80Abnormality of ocular smooth pursuit (HP:0000617)2.27267118
81Interstitial pulmonary disease (HP:0006530)2.25474052
82Dementia (HP:0000726)2.25268820
83Mediastinal lymphadenopathy (HP:0100721)2.24701311
84Recurrent gram-negative bacterial infections (HP:0005420)2.24316079
85Progressive inability to walk (HP:0002505)2.16616029
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.16353443
87Hemiplegia (HP:0002301)2.16094805
88Medial flaring of the eyebrow (HP:0010747)2.14591287
89Limb dystonia (HP:0002451)2.13568318
90Autoimmune thrombocytopenia (HP:0001973)2.12279150
91Delusions (HP:0000746)2.12038209
92Annular pancreas (HP:0001734)2.11832563
93Excessive salivation (HP:0003781)2.11040382
94Drooling (HP:0002307)2.11040382
95Congenital primary aphakia (HP:0007707)2.10501147
96Abnormality of the corticospinal tract (HP:0002492)2.09748882
97Rigidity (HP:0002063)2.09309213
98J-shaped sella turcica (HP:0002680)2.08681695
99Amyloidosis (HP:0011034)2.08531218
100Abnormal ciliary motility (HP:0012262)2.05928047
101Rapidly progressive (HP:0003678)2.05919436
102Postural instability (HP:0002172)2.05191016
103Inability to walk (HP:0002540)2.03116725
104Memory impairment (HP:0002354)2.02251348
105Nephrogenic diabetes insipidus (HP:0009806)1.99197828
106Urinary urgency (HP:0000012)1.98325271
107Intention tremor (HP:0002080)1.98224793
108Protruding tongue (HP:0010808)1.97325033
109Mutism (HP:0002300)1.97092546
110Status epilepticus (HP:0002133)1.96234186
111Impaired vibratory sensation (HP:0002495)1.95774206
112Ocular albinism (HP:0001107)1.95749208
113Distal upper limb amyotrophy (HP:0007149)1.95635822
114Upper limb amyotrophy (HP:0009129)1.95635822
115Asymmetric septal hypertrophy (HP:0001670)1.95425556
116Torticollis (HP:0000473)1.94698133
117Abnormality of the periventricular white matter (HP:0002518)1.94193175
118Dysmetric saccades (HP:0000641)1.93139956
119Gingivitis (HP:0000230)1.92779824
120Hyperparathyroidism (HP:0000843)1.92114255
121Specific learning disability (HP:0001328)1.91924192
122Blue irides (HP:0000635)1.91133919
123Progressive neurologic deterioration (HP:0002344)1.90725475
124Personality changes (HP:0000751)1.90675092
125Incomplete penetrance (HP:0003829)1.90641820
126Central scotoma (HP:0000603)1.90639566
127Abnormality of the nasal mucosa (HP:0000433)1.90604397
128Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.90555369
129Obstructive lung disease (HP:0006536)1.88212497
130Chronic obstructive pulmonary disease (HP:0006510)1.88212497
131Peripheral hypomyelination (HP:0007182)1.88149006
132Elevated erythrocyte sedimentation rate (HP:0003565)1.88138358
133Purpura (HP:0000979)1.87568031
134Pulmonary infiltrates (HP:0002113)1.87516402
135Termporal pattern (HP:0011008)1.87504026
136Insidious onset (HP:0003587)1.87504026
137Malnutrition (HP:0004395)1.86657306
138Cerebral aneurysm (HP:0004944)1.86486556
139Ventricular fibrillation (HP:0001663)1.85304285
140Epileptiform EEG discharges (HP:0011182)1.85033341
141Global brain atrophy (HP:0002283)1.84980830
142Focal dystonia (HP:0004373)1.83971475
143Abnormal hair whorl (HP:0010721)1.83641477
144Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83486946
145Stridor (HP:0010307)1.83142261
146Abnormal EKG (HP:0003115)1.81457908
147Genital tract atresia (HP:0001827)1.80616537
148Increased CSF protein (HP:0002922)1.80225928
149Deeply set eye (HP:0000490)1.78701148
150Decreased central vision (HP:0007663)1.78574677
151Glomerulonephritis (HP:0000099)1.78545227
152Onion bulb formation (HP:0003383)1.78010901
153Keratoconjunctivitis sicca (HP:0001097)1.77854628
154Iris hypopigmentation (HP:0007730)1.77467808
155Pustule (HP:0200039)1.77105599
156Abnormality of macular pigmentation (HP:0008002)1.76412494
157T lymphocytopenia (HP:0005403)1.76060249
158Generalized hypopigmentation of hair (HP:0011358)1.75652143
159Bony spicule pigmentary retinopathy (HP:0007737)1.75326869
160Prolonged QT interval (HP:0001657)1.75321296
161Bradykinesia (HP:0002067)1.74953663
162Increased serum ferritin (HP:0003281)1.74643133
163Abnormal respiratory motile cilium physiology (HP:0012261)1.74543713
164Lower limb amyotrophy (HP:0007210)1.73092545
165Gait ataxia (HP:0002066)1.72586460
166Vaginal atresia (HP:0000148)1.71948073
167Steppage gait (HP:0003376)1.71893495
168Lower limb muscle weakness (HP:0007340)1.69997168
169EEG with generalized epileptiform discharges (HP:0011198)1.69683062
170Spinal canal stenosis (HP:0003416)1.69673797
171Horizontal nystagmus (HP:0000666)1.69538278
172Abnormality of saccadic eye movements (HP:0000570)1.68391975
173Pointed chin (HP:0000307)1.67732355
174Hypothermia (HP:0002045)1.66888188

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.53880249
2NTRK34.42106706
3CASK3.28958991
4RIPK12.86284017
5MAP2K72.72315404
6MAP3K92.72222378
7MAP3K42.56512408
8TNIK2.55134125
9RIPK42.48210321
10IRAK32.44233564
11DAPK22.43811901
12MINK12.36481841
13MAP4K12.24429787
14MAP3K112.01948523
15ERN12.00139240
16PRPF4B1.99460009
17MARK11.99115542
18NTRK21.92542560
19TAOK21.80678184
20TRIB31.78394410
21PAK61.77133916
22MAPK131.62520317
23BMPR21.59159612
24SIK21.55449194
25MAP3K121.53544386
26FES1.52174567
27NTRK11.51347307
28TYK21.49403400
29TBK11.45106400
30SGK21.42843339
31CAMKK11.41099043
32PNCK1.39645576
33SGK4941.38483109
34SGK2231.38483109
35CDK51.38188664
36CAMKK21.37087105
37MAP3K141.34874877
38MAP3K31.34567369
39KSR21.34211930
40GRK51.33561090
41MAP2K41.33037884
42PLK21.32762214
43TESK11.32414743
44ZAP701.29525605
45TNK21.29366118
46DDR21.28752933
47TAOK11.25664097
48MAP3K131.23903878
49MAP2K31.23280399
50CSK1.22528477
51NEK61.21494146
52NME21.19759694
53DAPK11.19644006
54ICK1.16710496
55JAK11.15274071
56PRKCG1.14844071
57STK381.14293918
58CDK191.10499645
59WNK11.08501562
60SIK11.06662932
61MOS1.06421400
62KSR11.06002077
63ARAF1.05789047
64PRKD31.00848777
65CAMK11.00749038
66OXSR10.99885326
67SIK30.99624912
68IKBKE0.95139237
69MAPK120.93980123
70CAMK2A0.93776701
71SGK30.92640172
72EPHB10.91936034
73AKT30.91791904
74PINK10.90376549
75MAP3K20.88984745
76TGFBR20.85975345
77MAP2K60.85725264
78CAMK2B0.85472359
79TXK0.84069561
80ADRBK20.83737572
81UHMK10.82332748
82SGK10.81536773
83HIPK20.80515290
84JAK20.79974126
85STK110.78277242
86DYRK1A0.78138792
87JAK30.77916453
88IRAK20.76704080
89PRKG20.76265178
90IRAK40.74906046
91PRKCH0.73765676
92FGR0.73053963
93LMTK20.71943673
94CDK180.71349749
95SYK0.69359486
96GRK60.68063043
97MARK20.67821177
98IKBKB0.67689118
99PRKCE0.67071499
100CDK150.66929507
101GRK10.66691645
102PKN10.60810692
103PTK2B0.60050209
104CDC42BPA0.59385916
105LATS20.59107034
106HCK0.58889243
107CDK140.58844885
108CDK11A0.58268790
109BRAF0.57541635
110PDPK10.57220466
111TTN0.56749981
112PDK10.56435405
113PHKG10.55427995
114PHKG20.55427995
115ITK0.55250625
116LCK0.54830673
117BMX0.53668518
118PTK60.52937909
119CDK30.52573320
120BTK0.51993061
121CAMK40.51975745
122CAMK2D0.51756609
123TYRO30.50656234
124YES10.50190434
125GRK70.49769631
126CCNB10.49718026
127TESK20.48627117
128PRKD20.48297046
129RET0.47732358
130CAMK2G0.47535294
131FGFR40.46771291
132FYN0.46756408
133RPS6KA20.46562450
134PIM20.45614397
135MST1R0.45147983
136RAF10.43898058
137ABL20.42591189
138RPS6KA30.42374789
139ADRBK10.40916287
140CSNK1A10.40278146
141MAP3K10.40271865
142PRKACA0.39809143
143MAPK100.39253362
144STK390.39194359
145BLK0.39179900
146MAPK70.39013153
147CAMK1G0.37934748
148PRKCB0.37730372
149MAPKAPK50.37589275
150PRKCZ0.37552480
151PRKG10.37292277
152INSRR0.36180189

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.99460126
2Synaptic vesicle cycle_Homo sapiens_hsa047213.12394202
3Olfactory transduction_Homo sapiens_hsa047402.98191491
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85761252
5Morphine addiction_Homo sapiens_hsa050322.79637094
6Glutamatergic synapse_Homo sapiens_hsa047242.73655810
7Circadian entrainment_Homo sapiens_hsa047132.70052201
8GABAergic synapse_Homo sapiens_hsa047272.61223311
9Long-term potentiation_Homo sapiens_hsa047202.43932094
10Phototransduction_Homo sapiens_hsa047442.41944236
11Other glycan degradation_Homo sapiens_hsa005112.31553527
12Taste transduction_Homo sapiens_hsa047422.31019219
13Amphetamine addiction_Homo sapiens_hsa050312.30629068
14Salivary secretion_Homo sapiens_hsa049702.17089519
15Dopaminergic synapse_Homo sapiens_hsa047282.10439290
16Osteoclast differentiation_Homo sapiens_hsa043802.02227646
17Cholinergic synapse_Homo sapiens_hsa047252.00699133
18Insulin secretion_Homo sapiens_hsa049111.90133601
19Serotonergic synapse_Homo sapiens_hsa047261.89962164
20Long-term depression_Homo sapiens_hsa047301.81470377
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.78356045
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.74324580
23Gastric acid secretion_Homo sapiens_hsa049711.73948009
24Calcium signaling pathway_Homo sapiens_hsa040201.72788188
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.68538700
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67606280
27Lysosome_Homo sapiens_hsa041421.63085844
28Renin secretion_Homo sapiens_hsa049241.57236924
29Oxytocin signaling pathway_Homo sapiens_hsa049211.56510739
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55864730
31Cocaine addiction_Homo sapiens_hsa050301.55732188
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54204922
33Collecting duct acid secretion_Homo sapiens_hsa049661.45816012
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.45172904
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43813238
36Leishmaniasis_Homo sapiens_hsa051401.41860734
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.41558670
38TNF signaling pathway_Homo sapiens_hsa046681.38926525
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.36489150
40Tuberculosis_Homo sapiens_hsa051521.33093047
41cAMP signaling pathway_Homo sapiens_hsa040241.32488506
42GnRH signaling pathway_Homo sapiens_hsa049121.32324376
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.31494667
44Allograft rejection_Homo sapiens_hsa053301.30477632
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30324179
46Graft-versus-host disease_Homo sapiens_hsa053321.29037186
47Prion diseases_Homo sapiens_hsa050201.28756414
48B cell receptor signaling pathway_Homo sapiens_hsa046621.19256639
49Gap junction_Homo sapiens_hsa045401.17142101
50Pertussis_Homo sapiens_hsa051331.16540315
51Staphylococcus aureus infection_Homo sapiens_hsa051501.15621381
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12065565
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11673952
54Acute myeloid leukemia_Homo sapiens_hsa052211.09892136
55Malaria_Homo sapiens_hsa051441.09653855
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07064477
57Type II diabetes mellitus_Homo sapiens_hsa049301.04807303
58Axon guidance_Homo sapiens_hsa043601.03823356
59Autoimmune thyroid disease_Homo sapiens_hsa053201.03519635
60Toxoplasmosis_Homo sapiens_hsa051451.00531864
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99273939
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.96946425
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95647350
64ErbB signaling pathway_Homo sapiens_hsa040120.93916203
65Pancreatic secretion_Homo sapiens_hsa049720.92126983
66Melanogenesis_Homo sapiens_hsa049160.90488781
67Estrogen signaling pathway_Homo sapiens_hsa049150.89811398
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.89631084
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.89044852
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88331822
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87718641
72Influenza A_Homo sapiens_hsa051640.86503686
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85870336
74Cardiac muscle contraction_Homo sapiens_hsa042600.85062250
75Glioma_Homo sapiens_hsa052140.84710538
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84132542
77Hepatitis C_Homo sapiens_hsa051600.81950255
78Choline metabolism in cancer_Homo sapiens_hsa052310.80857632
79Antigen processing and presentation_Homo sapiens_hsa046120.79851570
80mTOR signaling pathway_Homo sapiens_hsa041500.79132826
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78879809
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75576086
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74723892
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73876772
85Vibrio cholerae infection_Homo sapiens_hsa051100.73234341
86Inositol phosphate metabolism_Homo sapiens_hsa005620.73006062
87MAPK signaling pathway_Homo sapiens_hsa040100.72914389
88Dorso-ventral axis formation_Homo sapiens_hsa043200.72586498
89Phagosome_Homo sapiens_hsa041450.71685347
90Measles_Homo sapiens_hsa051620.65988679
91Legionellosis_Homo sapiens_hsa051340.65601538
92Oocyte meiosis_Homo sapiens_hsa041140.64006858
93Hepatitis B_Homo sapiens_hsa051610.63970251
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.63517059
95Primary immunodeficiency_Homo sapiens_hsa053400.62700241
96Ras signaling pathway_Homo sapiens_hsa040140.62591946
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61852355
98Chemokine signaling pathway_Homo sapiens_hsa040620.61045064
99Chronic myeloid leukemia_Homo sapiens_hsa052200.60871000
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.60425162
101Amoebiasis_Homo sapiens_hsa051460.59716429
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.59426518
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58788992
104Shigellosis_Homo sapiens_hsa051310.58662931
105Thyroid hormone synthesis_Homo sapiens_hsa049180.58590354
106Hematopoietic cell lineage_Homo sapiens_hsa046400.58515947
107Renal cell carcinoma_Homo sapiens_hsa052110.57822348
108Alcoholism_Homo sapiens_hsa050340.56870998
109Rap1 signaling pathway_Homo sapiens_hsa040150.55999953
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.55942718
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55760007
112Dilated cardiomyopathy_Homo sapiens_hsa054140.55382833
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55232833
114African trypanosomiasis_Homo sapiens_hsa051430.52014879
115Circadian rhythm_Homo sapiens_hsa047100.51429020
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50645452
117Rheumatoid arthritis_Homo sapiens_hsa053230.46998126
118Ovarian steroidogenesis_Homo sapiens_hsa049130.45294768
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.44985381
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44251895
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42811991
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42133487
123Wnt signaling pathway_Homo sapiens_hsa043100.41697705
124Type I diabetes mellitus_Homo sapiens_hsa049400.40870781
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40081207
126Alzheimers disease_Homo sapiens_hsa050100.39741697
127VEGF signaling pathway_Homo sapiens_hsa043700.39261435
128Mineral absorption_Homo sapiens_hsa049780.39014585
129Ether lipid metabolism_Homo sapiens_hsa005650.36594169
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35253392
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33859947
132Endocytosis_Homo sapiens_hsa041440.33786585
133Endometrial cancer_Homo sapiens_hsa052130.32193928
134Non-small cell lung cancer_Homo sapiens_hsa052230.31206136
135Melanoma_Homo sapiens_hsa052180.29142516
136T cell receptor signaling pathway_Homo sapiens_hsa046600.28958864
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.26690903
138Sphingolipid metabolism_Homo sapiens_hsa006000.24676287
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24333218
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24060052
141Salmonella infection_Homo sapiens_hsa051320.22975745
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22678549
143Prolactin signaling pathway_Homo sapiens_hsa049170.20899075

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »