ZFYVE9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.70482619
2synaptic vesicle maturation (GO:0016188)4.49479577
3locomotory exploration behavior (GO:0035641)4.41227641
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.39363195
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.32334125
6vocalization behavior (GO:0071625)4.28614804
7glutamate secretion (GO:0014047)4.24774009
8neuronal action potential propagation (GO:0019227)4.15792942
9regulation of synaptic vesicle exocytosis (GO:2000300)4.02918889
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.00220088
11synaptic vesicle exocytosis (GO:0016079)3.89712862
12layer formation in cerebral cortex (GO:0021819)3.81200855
13synaptic vesicle docking involved in exocytosis (GO:0016081)3.78615353
14regulation of glutamate receptor signaling pathway (GO:1900449)3.66354281
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.65628707
16cellular potassium ion homeostasis (GO:0030007)3.64036393
17neurotransmitter secretion (GO:0007269)3.62411722
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.60750302
19gamma-aminobutyric acid transport (GO:0015812)3.58675688
20protein localization to synapse (GO:0035418)3.58094728
21regulation of synaptic vesicle transport (GO:1902803)3.52255151
22cerebellar Purkinje cell differentiation (GO:0021702)3.42246681
23neuron cell-cell adhesion (GO:0007158)3.40108431
24exploration behavior (GO:0035640)3.35012151
25cytoskeletal anchoring at plasma membrane (GO:0007016)3.33549765
26glutamate receptor signaling pathway (GO:0007215)3.32393938
27dendritic spine morphogenesis (GO:0060997)3.30385724
28cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.29178794
29regulation of neuronal synaptic plasticity (GO:0048168)3.27039245
30neurotransmitter-gated ion channel clustering (GO:0072578)3.26251686
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.24872026
32sodium ion export (GO:0071436)3.23621724
33synaptic transmission, glutamatergic (GO:0035249)3.22446719
34paraxial mesoderm development (GO:0048339)3.16523614
35neuron-neuron synaptic transmission (GO:0007270)3.14101145
36cell communication by electrical coupling (GO:0010644)3.12191903
37neuron recognition (GO:0008038)3.08063704
38dendrite morphogenesis (GO:0048813)3.05963360
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.05289588
40activation of protein kinase A activity (GO:0034199)3.02253831
41proline transport (GO:0015824)3.01809443
42cerebellar granule cell differentiation (GO:0021707)2.98380102
43regulation of synapse structural plasticity (GO:0051823)2.96970209
44regulation of excitatory postsynaptic membrane potential (GO:0060079)2.95241404
45neurotransmitter transport (GO:0006836)2.94682269
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.94598872
47axonal fasciculation (GO:0007413)2.92203385
48long-term memory (GO:0007616)2.90804539
49cell migration in hindbrain (GO:0021535)2.90512907
50neuromuscular process controlling balance (GO:0050885)2.88708991
51positive regulation of synapse maturation (GO:0090129)2.88615557
52positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88530120
53regulation of dendritic spine morphogenesis (GO:0061001)2.87125207
54positive regulation of dendritic spine morphogenesis (GO:0061003)2.85499314
55regulation of postsynaptic membrane potential (GO:0060078)2.84728515
56membrane depolarization during action potential (GO:0086010)2.83148143
57G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.82579625
58regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.82564222
59gamma-aminobutyric acid signaling pathway (GO:0007214)2.80174357
60transmission of nerve impulse (GO:0019226)2.79435526
61glycine transport (GO:0015816)2.79392588
62regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.78793371
63innervation (GO:0060384)2.75260367
64neuromuscular process controlling posture (GO:0050884)2.75031649
65cell communication involved in cardiac conduction (GO:0086065)2.74917233
66potassium ion import (GO:0010107)2.71791398
67regulation of neurotransmitter secretion (GO:0046928)2.71192013
68vesicle transport along microtubule (GO:0047496)2.71074326
69positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.70898372
70positive regulation of membrane potential (GO:0045838)2.69081287
71regulation of neurotransmitter levels (GO:0001505)2.68440423
72establishment of nucleus localization (GO:0040023)2.68195266
73regulation of synaptic plasticity (GO:0048167)2.66667033
74regulation of synaptic transmission, glutamatergic (GO:0051966)2.66190689
75synaptic vesicle endocytosis (GO:0048488)2.65718630
76presynaptic membrane assembly (GO:0097105)2.62506304
77potassium ion homeostasis (GO:0055075)2.61527542
78cellular sodium ion homeostasis (GO:0006883)2.60322241
79neuronal ion channel clustering (GO:0045161)2.57328762
80regulation of vesicle fusion (GO:0031338)2.56949238
81hemidesmosome assembly (GO:0031581)2.56769098
82negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56709483
83membrane depolarization (GO:0051899)2.55873355
84long-term synaptic potentiation (GO:0060291)2.55596067
85regulation of clathrin-mediated endocytosis (GO:2000369)2.55107563
86peripheral nervous system axon ensheathment (GO:0032292)2.54936740
87myelination in peripheral nervous system (GO:0022011)2.54936740
88synapse organization (GO:0050808)2.54760073
89positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.54606054
90regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.54291515
91dendritic spine organization (GO:0097061)2.54033299
92presynaptic membrane organization (GO:0097090)2.51839187
93postsynaptic membrane organization (GO:0001941)2.51301271
94plasma membrane repair (GO:0001778)2.51298242
95regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.50998755
96neuromuscular process (GO:0050905)2.50853840
97positive regulation of potassium ion transmembrane transport (GO:1901381)2.50643723
98organelle transport along microtubule (GO:0072384)2.50485822
99cell differentiation in hindbrain (GO:0021533)2.49225354
100regulation of neurotransmitter transport (GO:0051588)2.48125007
101membrane hyperpolarization (GO:0060081)2.47463457
102regulation of membrane repolarization (GO:0060306)2.45576037
103mating behavior (GO:0007617)2.44947672
104synapse assembly (GO:0007416)2.44768368
105detection of calcium ion (GO:0005513)2.44502990
106adherens junction assembly (GO:0034333)2.44317863
107regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.43532582
108positive regulation of potassium ion transport (GO:0043268)2.43175398
109sarcoplasmic reticulum calcium ion transport (GO:0070296)2.42240276
110axon extension (GO:0048675)2.37809528
111regulation of NFAT protein import into nucleus (GO:0051532)2.37236903
112focal adhesion assembly (GO:0048041)2.35535997
113cell-substrate adherens junction assembly (GO:0007045)2.35535997
114amino acid import (GO:0043090)2.33993015
115positive regulation of dendritic spine development (GO:0060999)2.32191016
116nuclear pore complex assembly (GO:0051292)2.31575119
117apical protein localization (GO:0045176)2.31120740
118cardiac myofibril assembly (GO:0055003)2.29678153
119cell-substrate junction assembly (GO:0007044)2.29433039
120neuron projection extension (GO:1990138)2.24947939
121negative regulation of dendrite morphogenesis (GO:0050774)2.23618496
122neuromuscular junction development (GO:0007528)2.20726431
123hippo signaling (GO:0035329)2.20036357
124membrane assembly (GO:0071709)2.19370969
125myotube differentiation (GO:0014902)2.18775267
126regulation of cell communication by electrical coupling (GO:0010649)2.18431587
127myoblast fusion (GO:0007520)2.16845452
128regulation of synapse maturation (GO:0090128)2.15470339
129notochord development (GO:0030903)2.15155663
130myofibril assembly (GO:0030239)2.11457592
131desmosome organization (GO:0002934)2.09847377
132embryonic retina morphogenesis in camera-type eye (GO:0060059)2.09221672
133developmental cell growth (GO:0048588)2.08468177
134regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.08253977
135L-amino acid import (GO:0043092)2.06910354
136muscle filament sliding (GO:0030049)2.04070204
137actin-myosin filament sliding (GO:0033275)2.04070204
138regulation of axon extension involved in axon guidance (GO:0048841)2.03521536
139regulation of cAMP-dependent protein kinase activity (GO:2000479)2.03511290
140asymmetric protein localization (GO:0008105)2.02091610
141protein retention in ER lumen (GO:0006621)2.00156632
142positive regulation of dendrite development (GO:1900006)1.98752649
143actin-mediated cell contraction (GO:0070252)1.97250935
144clathrin coat assembly (GO:0048268)1.96437554
145regulation of Rac protein signal transduction (GO:0035020)1.96051997
146positive regulation of calcium ion transmembrane transporter activity (GO:1901021)1.94280053
147nuclear pore organization (GO:0006999)1.94017972
148suckling behavior (GO:0001967)1.93407230
149morphogenesis of an epithelial sheet (GO:0002011)1.93318847
150camera-type eye morphogenesis (GO:0048593)1.92436243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.43367233
2GBX2_23144817_ChIP-Seq_PC3_Human3.15645489
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71379080
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62861977
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.55374419
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46979454
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46979454
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25750329
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.21798363
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21305798
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19586232
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19431722
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19070505
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11393333
15DROSHA_22980978_ChIP-Seq_HELA_Human2.09739867
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.09420676
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04551418
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97029195
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.96772690
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.96247234
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.95796537
22REST_21632747_ChIP-Seq_MESCs_Mouse1.95373106
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.87240459
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.86555880
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86137439
26AR_21572438_ChIP-Seq_LNCaP_Human1.83848444
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.72957122
28SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.65216817
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.63313495
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59695388
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.58947063
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.57900491
33* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56457692
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52892577
35TAF15_26573619_Chip-Seq_HEK293_Human1.52054830
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51598351
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49378156
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47191308
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46670011
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.45425096
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44151059
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43519397
43CLOCK_20551151_ChIP-Seq_293T_Human1.41815281
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41299731
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.39862589
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38047766
47DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36897607
48ISL1_27105846_Chip-Seq_CPCs_Mouse1.34139959
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.33899751
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33574788
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33496020
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33116702
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.32644125
54* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32321498
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.29763140
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.28579765
57P300_19829295_ChIP-Seq_ESCs_Human1.28298793
58STAT3_23295773_ChIP-Seq_U87_Human1.28288855
59AHR_22903824_ChIP-Seq_MCF-7_Human1.27067587
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26553778
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25595756
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.25309986
63ZNF274_21170338_ChIP-Seq_K562_Hela1.23184346
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23010247
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22942734
66AR_19668381_ChIP-Seq_PC3_Human1.22890037
67AR_21909140_ChIP-Seq_LNCAP_Human1.22867119
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22025104
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21956399
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21772901
71* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21667214
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21509740
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.21244077
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20580453
75AR_25329375_ChIP-Seq_VCAP_Human1.20357693
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.20170967
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.20076942
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18473976
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17201599
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16719890
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.15302172
82SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15244451
83ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15176701
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14515886
85SOX9_26525672_Chip-Seq_HEART_Mouse1.14425461
86TP53_16413492_ChIP-PET_HCT116_Human1.14350076
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13474184
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.12691717
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11304875
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11304875
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11298162
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10693504
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10415248
94BCAT_22108803_ChIP-Seq_LS180_Human1.09719073
95TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09635228
96ESR1_20079471_ChIP-ChIP_T-47D_Human1.09634141
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09447193
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09098127
99* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08917057
100TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08732783
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08502719
102TCF4_23295773_ChIP-Seq_U87_Human1.08110509
103KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06565204
104STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05337379
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04624748
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03924335
107SMAD4_21741376_ChIP-Seq_HESCs_Human1.03642599
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03593938
109* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03062970
110FOXA2_19822575_ChIP-Seq_HepG2_Human1.02354972
111KDM2B_26808549_Chip-Seq_K562_Human1.01898323
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01273901
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01193185
114SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00685374
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.99448936
116PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98498262
117* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98322693
118* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97505882
119RNF2_27304074_Chip-Seq_NSC_Mouse0.96714290
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95654249
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94672301
122TP53_18474530_ChIP-ChIP_U2OS_Human0.94264699
123RXR_22108803_ChIP-Seq_LS180_Human0.94073014
124RUNX2_22187159_ChIP-Seq_PCA_Human0.93371207
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93349685
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92670485
127SMAD3_21741376_ChIP-Seq_ESCs_Human0.92476384
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90057661
129SMAD4_21741376_ChIP-Seq_EPCs_Human0.89676809
130VDR_22108803_ChIP-Seq_LS180_Human0.89628860
131FUS_26573619_Chip-Seq_HEK293_Human0.88853530
132* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87799743
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86840640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.08185743
2MP0003880_abnormal_central_pattern3.51505461
3MP0004270_analgesia3.43383080
4MP0003635_abnormal_synaptic_transmissio3.37962539
5MP0009046_muscle_twitch2.71639511
6MP0002063_abnormal_learning/memory/cond2.64530978
7MP0009745_abnormal_behavioral_response2.63655742
8MP0002064_seizures2.50358687
9MP0001486_abnormal_startle_reflex2.27963887
10MP0002734_abnormal_mechanical_nocicepti2.24181634
11MP0005423_abnormal_somatic_nervous2.24076948
12MP0002272_abnormal_nervous_system2.23586642
13MP0008438_abnormal_cutaneous_collagen2.21057890
14MP0001968_abnormal_touch/_nociception2.17708266
15MP0002572_abnormal_emotion/affect_behav2.15769297
16MP0009780_abnormal_chondrocyte_physiolo2.13817167
17MP0004272_abnormal_basement_membrane2.09292824
18MP0004145_abnormal_muscle_electrophysio2.00682769
19MP0003941_abnormal_skin_development1.84967747
20MP0000751_myopathy1.82004393
21MP0001440_abnormal_grooming_behavior1.81647092
22MP0002822_catalepsy1.79978486
23MP0005275_abnormal_skin_tensile1.78603355
24MP0004885_abnormal_endolymph1.77363457
25MP0002067_abnormal_sensory_capabilities1.73361516
26MP0000778_abnormal_nervous_system1.68434457
27MP0001501_abnormal_sleep_pattern1.68366033
28MP0002184_abnormal_innervation1.65123754
29MP0008569_lethality_at_weaning1.61162578
30MP0002736_abnormal_nociception_after1.54024204
31MP0002735_abnormal_chemical_nociception1.53481051
32MP0004858_abnormal_nervous_system1.50972561
33MP0003329_amyloid_beta_deposits1.50268112
34MP0002733_abnormal_thermal_nociception1.48954859
35MP0002837_dystrophic_cardiac_calcinosis1.47820236
36MP0000537_abnormal_urethra_morphology1.45707428
37MP0002909_abnormal_adrenal_gland1.45154201
38MP0005386_behavior/neurological_phenoty1.43809227
39MP0004924_abnormal_behavior1.43809227
40MP0000955_abnormal_spinal_cord1.41575449
41MP0001970_abnormal_pain_threshold1.39141407
42MP0002557_abnormal_social/conspecific_i1.37564243
43MP0010352_gastrointestinal_tract_polyps1.36036960
44MP0001984_abnormal_olfaction1.35230615
45MP0005409_darkened_coat_color1.31362024
46MP0004811_abnormal_neuron_physiology1.31326263
47MP0010234_abnormal_vibrissa_follicle1.29512803
48MP0010368_abnormal_lymphatic_system1.28467863
49MP0002882_abnormal_neuron_morphology1.27514868
50MP0003566_abnormal_cell_adhesion1.26503325
51MP0002066_abnormal_motor_capabilities/c1.22064039
52MP0000733_abnormal_muscle_development1.21921926
53MP0003879_abnormal_hair_cell1.20974525
54MP0000762_abnormal_tongue_morphology1.19804095
55MP0005551_abnormal_eye_electrophysiolog1.19508813
56MP0003890_abnormal_embryonic-extraembry1.18314853
57MP0004215_abnormal_myocardial_fiber1.17851191
58MP0005646_abnormal_pituitary_gland1.17146484
59MP0010030_abnormal_orbit_morphology1.16759744
60MP0006276_abnormal_autonomic_nervous1.16705715
61MP0000566_synostosis1.15645225
62MP0002269_muscular_atrophy1.10714248
63MP0000013_abnormal_adipose_tissue1.10399677
64MP0000003_abnormal_adipose_tissue1.10232652
65MP0003950_abnormal_plasma_membrane1.10145616
66MP0004233_abnormal_muscle_weight1.10088715
67MP0003633_abnormal_nervous_system1.09238128
68MP0001299_abnormal_eye_distance/1.08324811
69MP0000428_abnormal_craniofacial_morphol1.07712510
70MP0005257_abnormal_intraocular_pressure1.06040313
71MP0001177_atelectasis1.06000975
72MP0004084_abnormal_cardiac_muscle1.05922484
73MP0000462_abnormal_digestive_system1.05134984
74MP0005503_abnormal_tendon_morphology1.04950002
75MP0005187_abnormal_penis_morphology1.04298529
76MP0003123_paternal_imprinting1.03323742
77MP0003937_abnormal_limbs/digits/tail_de1.02154659
78MP0004085_abnormal_heartbeat0.99774830
79MP0001661_extended_life_span0.99143499
80MP0005623_abnormal_meninges_morphology0.98986059
81MP0004130_abnormal_muscle_cell0.98981269
82MP0004043_abnormal_pH_regulation0.98943974
83MP0002152_abnormal_brain_morphology0.98503388
84MP0003631_nervous_system_phenotype0.98487684
85MP0004142_abnormal_muscle_tone0.97617901
86MP0003787_abnormal_imprinting0.96622505
87MP0000747_muscle_weakness0.96546846
88MP0006138_congestive_heart_failure0.95709365
89MP0003942_abnormal_urinary_system0.95605176
90MP0003646_muscle_fatigue0.95599820
91MP0001502_abnormal_circadian_rhythm0.93259274
92MP0002697_abnormal_eye_size0.92595233
93MP0005369_muscle_phenotype0.92165099
94MP0003122_maternal_imprinting0.92140567
95MP0002106_abnormal_muscle_physiology0.91000276
96MP0003137_abnormal_impulse_conducting0.90484651
97MP0009672_abnormal_birth_weight0.90059430
98MP0002229_neurodegeneration0.89903819
99MP0003632_abnormal_nervous_system0.89275911
100MP0004036_abnormal_muscle_relaxation0.88981734
101MP0003690_abnormal_glial_cell0.88089907
102MP0005620_abnormal_muscle_contractility0.88050191
103MP0003283_abnormal_digestive_organ0.87730367
104MP0004742_abnormal_vestibular_system0.87653821
105MP0003861_abnormal_nervous_system0.86009424
106MP0002896_abnormal_bone_mineralization0.85970832
107MP0003935_abnormal_craniofacial_develop0.85097827
108MP0009250_abnormal_appendicular_skeleto0.84098876
109MP0001346_abnormal_lacrimal_gland0.83862311
110MP0001485_abnormal_pinna_reflex0.83625553
111MP0002234_abnormal_pharynx_morphology0.83365505
112MP0000569_abnormal_digit_pigmentation0.82979305
113MP0008961_abnormal_basal_metabolism0.82103131
114MP0003868_abnormal_feces_composition0.81354744
115MP0004484_altered_response_of0.80537973
116MP0001958_emphysema0.79204822
117MP0002090_abnormal_vision0.78718541
118MP0002752_abnormal_somatic_nervous0.78591039
119MP0002108_abnormal_muscle_morphology0.78405987
120MP0003634_abnormal_glial_cell0.76635731
121MP0002084_abnormal_developmental_patter0.76371595
122MP0002069_abnormal_eating/drinking_beha0.76362123
123MP0000749_muscle_degeneration0.76269289
124MP0000534_abnormal_ureter_morphology0.76221996
125MP0000579_abnormal_nail_morphology0.75422329
126MP0005645_abnormal_hypothalamus_physiol0.75421906
127MP0002081_perinatal_lethality0.75068256
128MP0010630_abnormal_cardiac_muscle0.73614314
129MP0003115_abnormal_respiratory_system0.73556654
130MP0009053_abnormal_anal_canal0.73546831
131MP0001963_abnormal_hearing_physiology0.73467799
132MP0004185_abnormal_adipocyte_glucose0.73194941
133MP0002233_abnormal_nose_morphology0.73142514
134MP0010678_abnormal_skin_adnexa0.72500521
135MP0005499_abnormal_olfactory_system0.71639368
136MP0005394_taste/olfaction_phenotype0.71639368
137MP0002114_abnormal_axial_skeleton0.71473808
138MP0003755_abnormal_palate_morphology0.71383121
139MP0004087_abnormal_muscle_fiber0.67652243
140MP0000920_abnormal_myelination0.67256521
141MP0005248_abnormal_Harderian_gland0.65123142
142MP0003385_abnormal_body_wall0.64317148
143MP0006072_abnormal_retinal_apoptosis0.63642913
144MP0000759_abnormal_skeletal_muscle0.63429142
145MP0005535_abnormal_body_temperature0.62267885
146MP0003705_abnormal_hypodermis_morpholog0.61091761
147MP0000631_abnormal_neuroendocrine_gland0.60289995
148MP0002796_impaired_skin_barrier0.60270228

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.38742216
2Myokymia (HP:0002411)4.61727822
3Focal seizures (HP:0007359)4.24423748
4Action tremor (HP:0002345)3.91351979
5Atonic seizures (HP:0010819)3.74372402
6Progressive cerebellar ataxia (HP:0002073)3.65064395
7Febrile seizures (HP:0002373)3.62393795
8Visual hallucinations (HP:0002367)3.43980651
9Epileptic encephalopathy (HP:0200134)3.32815411
10Absence seizures (HP:0002121)3.29122646
11Type 1 muscle fiber predominance (HP:0003803)3.17374211
12Dysdiadochokinesis (HP:0002075)3.15297195
13Generalized tonic-clonic seizures (HP:0002069)3.07222763
14Muscle fiber inclusion bodies (HP:0100299)3.03025069
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.99094848
16Nemaline bodies (HP:0003798)2.96860751
17Broad-based gait (HP:0002136)2.87811193
18Dialeptic seizures (HP:0011146)2.86438698
19Protrusio acetabuli (HP:0003179)2.74483322
20Gaze-evoked nystagmus (HP:0000640)2.71270395
21Termporal pattern (HP:0011008)2.68786873
22Insidious onset (HP:0003587)2.68786873
23Dysmetric saccades (HP:0000641)2.67736126
24Shallow orbits (HP:0000586)2.61831271
25Urinary bladder sphincter dysfunction (HP:0002839)2.59617387
26Impaired vibration sensation in the lower limbs (HP:0002166)2.59061813
27Exercise-induced myalgia (HP:0003738)2.57927647
28Ankle clonus (HP:0011448)2.50576521
29Dysmetria (HP:0001310)2.49705182
30Premature rupture of membranes (HP:0001788)2.46876651
31Ventricular fibrillation (HP:0001663)2.46817207
32Hyperventilation (HP:0002883)2.46567159
33Genetic anticipation (HP:0003743)2.45211440
34Intention tremor (HP:0002080)2.43635037
35Abnormality of the lower motor neuron (HP:0002366)2.43474504
36Impaired social interactions (HP:0000735)2.39970987
37Abnormal social behavior (HP:0012433)2.39970987
38Postural instability (HP:0002172)2.39729198
39Poor eye contact (HP:0000817)2.37142344
40Bundle branch block (HP:0011710)2.33528761
41Truncal ataxia (HP:0002078)2.32462815
42Scanning speech (HP:0002168)2.31386902
43Excessive salivation (HP:0003781)2.30765198
44Drooling (HP:0002307)2.30765198
45Supranuclear gaze palsy (HP:0000605)2.30718103
46Depression (HP:0000716)2.29682891
47Overgrowth (HP:0001548)2.22846329
48Amblyopia (HP:0000646)2.19948349
49Abnormality of the corticospinal tract (HP:0002492)2.18693075
50Muscle hypertrophy of the lower extremities (HP:0008968)2.17925999
51Atrophic scars (HP:0001075)2.16601960
52Difficulty running (HP:0009046)2.15035031
53Urinary urgency (HP:0000012)2.13417021
54Anxiety (HP:0000739)2.11562850
55Pheochromocytoma (HP:0002666)2.11443295
56Hemiparesis (HP:0001269)2.08343679
57Hemiplegia (HP:0002301)2.08239109
58Coronal craniosynostosis (HP:0004440)2.07779703
59Fetal akinesia sequence (HP:0001989)2.03440790
60Arterial tortuosity (HP:0005116)2.02186380
61Vascular tortuosity (HP:0004948)2.00705535
62Aplasia involving bones of the upper limbs (HP:0009823)2.00418650
63Aplasia of the phalanges of the hand (HP:0009802)2.00418650
64Aplasia involving bones of the extremities (HP:0009825)2.00418650
65Calf muscle hypertrophy (HP:0008981)1.99255937
66Cerebral inclusion bodies (HP:0100314)1.98827398
67Megalencephaly (HP:0001355)1.98409374
68Insomnia (HP:0100785)1.97345088
69Spinal rigidity (HP:0003306)1.96441204
70Abnormal eating behavior (HP:0100738)1.96031144
71Papillary thyroid carcinoma (HP:0002895)1.94029662
72Torticollis (HP:0000473)1.93243643
73Round ear (HP:0100830)1.92761929
74Sudden death (HP:0001699)1.92516317
75Epileptiform EEG discharges (HP:0011182)1.92435121
76Mildly elevated creatine phosphokinase (HP:0008180)1.91877268
77Impaired vibratory sensation (HP:0002495)1.91726229
78Status epilepticus (HP:0002133)1.91584133
79Spastic gait (HP:0002064)1.91321182
80Hyporeflexia of lower limbs (HP:0002600)1.91035138
81Impaired smooth pursuit (HP:0007772)1.89110402
82EEG with generalized epileptiform discharges (HP:0011198)1.87149914
83Neurofibrillary tangles (HP:0002185)1.86737397
84Right ventricular cardiomyopathy (HP:0011663)1.86602158
85Abnormality of the calf musculature (HP:0001430)1.84848709
86Turricephaly (HP:0000262)1.84608508
87Myotonia (HP:0002486)1.84545855
88Lower limb muscle weakness (HP:0007340)1.83611818
89Postural tremor (HP:0002174)1.83361520
90Subaortic stenosis (HP:0001682)1.82983386
91Abnormality of the left ventricular outflow tract (HP:0011103)1.82983386
92Vertebral arch anomaly (HP:0008438)1.80831161
93Prolonged QT interval (HP:0001657)1.80162926
94Broad metatarsal (HP:0001783)1.79995270
95Hyperacusis (HP:0010780)1.78928913
96Absent speech (HP:0001344)1.77816133
97Limited hip movement (HP:0008800)1.77623033
98Hypsarrhythmia (HP:0002521)1.77509567
99Progressive inability to walk (HP:0002505)1.76795732
100Syncope (HP:0001279)1.76552643
101Blue irides (HP:0000635)1.75886207
102Bladder diverticulum (HP:0000015)1.74849854
103Exercise-induced muscle cramps (HP:0003710)1.74318613
104Calcaneovalgus deformity (HP:0001848)1.72889602
105Obstructive sleep apnea (HP:0002870)1.72194535
106Lower limb amyotrophy (HP:0007210)1.71651056
107Central scotoma (HP:0000603)1.70456835
108Renovascular hypertension (HP:0100817)1.70254870
109Hepatoblastoma (HP:0002884)1.68646456
110Agitation (HP:0000713)1.67520461
111Increased connective tissue (HP:0009025)1.66676901
112Abnormality of ocular smooth pursuit (HP:0000617)1.66612024
113Abnormality of skeletal muscle fiber size (HP:0012084)1.66014213
114Cubitus valgus (HP:0002967)1.65863344
115Focal dystonia (HP:0004373)1.65428836
116Distal lower limb amyotrophy (HP:0008944)1.65153018
117Bradykinesia (HP:0002067)1.64319651
118Neuroendocrine neoplasm (HP:0100634)1.64157512
119Cutaneous finger syndactyly (HP:0010554)1.63595502
120Mutism (HP:0002300)1.62278406
121Increased variability in muscle fiber diameter (HP:0003557)1.62105307
122Resting tremor (HP:0002322)1.61966606
123Wormian bones (HP:0002645)1.61359132
124Abnormal EKG (HP:0003115)1.60305850
125Gait ataxia (HP:0002066)1.60182215
126Generalized myoclonic seizures (HP:0002123)1.60064418
127Aortic aneurysm (HP:0004942)1.59946248
128Achilles tendon contracture (HP:0001771)1.59468009
129Distal arthrogryposis (HP:0005684)1.59296076
130Mitral valve prolapse (HP:0001634)1.58118000
131Hammertoe (HP:0001765)1.57642104
132Incomplete penetrance (HP:0003829)1.57598804
133Neonatal short-limb short stature (HP:0008921)1.57456448
134Abnormality of the Achilles tendon (HP:0005109)1.57438301
135Bronchomalacia (HP:0002780)1.56380248
136Lower limb asymmetry (HP:0100559)1.55199783
137Cutaneous syndactyly (HP:0012725)1.55126835
138Shoulder girdle muscle weakness (HP:0003547)1.54971858
139Overriding aorta (HP:0002623)1.54959970
140Relative macrocephaly (HP:0004482)1.54946609
141Aortic dissection (HP:0002647)1.54461930
142Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.53567962
143Aqueductal stenosis (HP:0002410)1.53244699
144Impaired pain sensation (HP:0007328)1.53213399
145Abnormality of pain sensation (HP:0010832)1.53213399
146Tetraplegia (HP:0002445)1.52924218
147Macroorchidism (HP:0000053)1.52681699
148EMG: myopathic abnormalities (HP:0003458)1.52046765
149Bowel diverticulosis (HP:0005222)1.49585789
150Ulnar bowing (HP:0003031)1.49420669
151Hypoplasia of the iris (HP:0007676)1.48814258
152Cerebral aneurysm (HP:0004944)1.47337795
153Scapular winging (HP:0003691)1.47132736
154Ankyloglossia (HP:0010296)1.46277827
155Deformed tarsal bones (HP:0008119)1.45202734
156Advanced eruption of teeth (HP:0006288)1.44787251
157Heterotopia (HP:0002282)1.43597579

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.59793329
2EPHA43.17753564
3MAP3K43.16082184
4MAP3K93.14359561
5MARK12.65674355
6EEF2K2.33119781
7MAP2K42.25356048
8PAK62.16564965
9MINK12.09613040
10MAP2K71.98870766
11PRKD31.97009852
12DAPK21.95899691
13LATS21.88619810
14NTRK21.78461604
15PHKG21.77744786
16PHKG11.77744786
17KSR21.75261156
18MET1.68603603
19CASK1.64502967
20NTRK11.64052008
21STK381.63819021
22LATS11.53600879
23CAMKK11.47239495
24MAP3K21.43451195
25CDK121.32834541
26KSR11.29749196
27PTK21.28963468
28SGK2231.28907813
29SGK4941.28907813
30PNCK1.26768479
31WNK11.26287090
32CDK51.22330423
33BRD41.18060400
34TYRO31.17421428
35STK38L1.16791806
36PLK21.15458601
37PINK11.13819079
38SCYL21.13288625
39SGK21.12885426
40OXSR11.12475670
41MAPK131.12198322
42PAK31.10450389
43LMTK21.08675781
44FER1.07961201
45TRIB31.07397791
46CAMK1G1.05252639
47RIPK11.04506609
48SGK31.03762478
49PRKCG1.03084957
50DDR21.02900299
51GRK51.01386625
52STK111.00606096
53AKT30.99675112
54CAMKK20.95636933
55CAMK2A0.93288753
56PRPF4B0.90151651
57RET0.89101722
58PRKCH0.85049823
59UHMK10.84642424
60MTOR0.83693038
61PDGFRB0.82870598
62FGFR20.81372877
63SGK10.80998872
64STK390.80384446
65MST1R0.79733498
66PDGFRA0.76713575
67DMPK0.76386427
68WNK30.75352867
69MAP3K70.73226670
70TAOK10.73078362
71CAMK2B0.71581176
72ERBB40.71285978
73MARK20.70248019
74OBSCN0.70208331
75FGFR10.70183771
76CDK190.70087366
77DYRK1A0.69964736
78PKN20.69295197
79FRK0.69154373
80ERBB30.67963640
81NEK90.67574176
82PAK20.67281986
83NEK60.67008721
84MAP3K120.66209699
85WNK40.65481390
86CAMK10.63860699
87CDK150.63376180
88CDK140.62965718
89PDK40.62280376
90PDK30.62280376
91CDK180.61857910
92CAMK2D0.61208230
93PRKCE0.60874964
94MAP3K60.60265000
95CAMK2G0.60023307
96BRAF0.59951557
97RPS6KA30.59713741
98AKT20.59199873
99ALK0.58592366
100DAPK10.58435230
101PDPK10.55971848
102RPS6KB10.55842642
103NEK10.55522763
104SIK20.54716511
105CDC42BPA0.54499373
106PRKCZ0.54484863
107CSNK1G20.54028448
108ICK0.53938898
109MAP2K10.53904557
110CAMK40.53810035
111LIMK10.53304330
112TNIK0.53025290
113PKN10.52749025
114BCR0.52690674
115EPHB20.52087516
116CSNK1E0.51581312
117PTK2B0.51311002
118CDK11A0.50432556
119MOS0.50164328
120RAF10.50096752
121TRPM70.49697525
122TTN0.49599503
123ARAF0.49318772
124MAPK100.48510528
125PRKAA10.48270178
126ROCK20.47719922
127ROCK10.47575230
128CAMK1D0.46220450
129PBK0.45672819
130MAPK120.42120016
131TIE10.41580276

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.95963174
2Nitrogen metabolism_Homo sapiens_hsa009102.48312514
3Synaptic vesicle cycle_Homo sapiens_hsa047212.42823656
4GABAergic synapse_Homo sapiens_hsa047272.29521060
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15971007
6Circadian entrainment_Homo sapiens_hsa047132.15888844
7Long-term potentiation_Homo sapiens_hsa047202.14051955
8Glutamatergic synapse_Homo sapiens_hsa047242.12003791
9Olfactory transduction_Homo sapiens_hsa047402.04927234
10Morphine addiction_Homo sapiens_hsa050321.89373591
11Amphetamine addiction_Homo sapiens_hsa050311.88697996
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87536214
13Salivary secretion_Homo sapiens_hsa049701.78346318
14Insulin secretion_Homo sapiens_hsa049111.75350398
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71648812
16Dopaminergic synapse_Homo sapiens_hsa047281.70597523
17Gastric acid secretion_Homo sapiens_hsa049711.67117609
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56273289
19Adherens junction_Homo sapiens_hsa045201.55525640
20ECM-receptor interaction_Homo sapiens_hsa045121.54476474
21Taste transduction_Homo sapiens_hsa047421.54200576
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51208632
23Renin secretion_Homo sapiens_hsa049241.50907148
24Cholinergic synapse_Homo sapiens_hsa047251.49764098
25Oxytocin signaling pathway_Homo sapiens_hsa049211.43894608
26Long-term depression_Homo sapiens_hsa047301.42899426
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42179272
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39377055
29Focal adhesion_Homo sapiens_hsa045101.30859726
30Calcium signaling pathway_Homo sapiens_hsa040201.27206721
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26914299
32GnRH signaling pathway_Homo sapiens_hsa049121.25462183
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24213835
34Cocaine addiction_Homo sapiens_hsa050301.22812098
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22390050
36Serotonergic synapse_Homo sapiens_hsa047261.19950268
37Arginine biosynthesis_Homo sapiens_hsa002201.17883994
38Gap junction_Homo sapiens_hsa045401.17442920
39Type II diabetes mellitus_Homo sapiens_hsa049301.16867843
40cAMP signaling pathway_Homo sapiens_hsa040241.13745964
41Axon guidance_Homo sapiens_hsa043601.13210282
42Dorso-ventral axis formation_Homo sapiens_hsa043201.08671801
43Dilated cardiomyopathy_Homo sapiens_hsa054141.07571471
44Bile secretion_Homo sapiens_hsa049761.05046105
45Vitamin B6 metabolism_Homo sapiens_hsa007501.03440217
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02402501
47Estrogen signaling pathway_Homo sapiens_hsa049151.02276711
48Melanogenesis_Homo sapiens_hsa049161.00740856
49Phototransduction_Homo sapiens_hsa047441.00598505
50Butanoate metabolism_Homo sapiens_hsa006500.99904792
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99810505
52Cardiac muscle contraction_Homo sapiens_hsa042600.98773978
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98352004
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98087274
55Glioma_Homo sapiens_hsa052140.95665562
56Proteoglycans in cancer_Homo sapiens_hsa052050.95637629
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95052707
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.92882899
59Thyroid cancer_Homo sapiens_hsa052160.91908105
60ErbB signaling pathway_Homo sapiens_hsa040120.89095519
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.88258408
62Arginine and proline metabolism_Homo sapiens_hsa003300.87129672
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84742787
64Protein digestion and absorption_Homo sapiens_hsa049740.84590098
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83617829
66Glucagon signaling pathway_Homo sapiens_hsa049220.82599774
67Lysine degradation_Homo sapiens_hsa003100.81485316
68Collecting duct acid secretion_Homo sapiens_hsa049660.81230103
69Pancreatic secretion_Homo sapiens_hsa049720.79506238
70Thyroid hormone synthesis_Homo sapiens_hsa049180.75952203
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75869224
72Basal cell carcinoma_Homo sapiens_hsa052170.75581024
73Circadian rhythm_Homo sapiens_hsa047100.72085897
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71549496
75MicroRNAs in cancer_Homo sapiens_hsa052060.71118481
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.70054129
77Fatty acid biosynthesis_Homo sapiens_hsa000610.67723783
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.67488420
79Choline metabolism in cancer_Homo sapiens_hsa052310.65354905
80mTOR signaling pathway_Homo sapiens_hsa041500.63482462
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63332220
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61648699
83Tight junction_Homo sapiens_hsa045300.60864460
84Insulin signaling pathway_Homo sapiens_hsa049100.60081402
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59857398
86Oocyte meiosis_Homo sapiens_hsa041140.59217894
87Biosynthesis of amino acids_Homo sapiens_hsa012300.58898843
88Amoebiasis_Homo sapiens_hsa051460.58877109
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58405163
90Colorectal cancer_Homo sapiens_hsa052100.58032272
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57829218
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56842920
93Alcoholism_Homo sapiens_hsa050340.55510590
94MAPK signaling pathway_Homo sapiens_hsa040100.55330798
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54423547
96Melanoma_Homo sapiens_hsa052180.53932251
97Ovarian steroidogenesis_Homo sapiens_hsa049130.53705504
98Chronic myeloid leukemia_Homo sapiens_hsa052200.53163194
99Vibrio cholerae infection_Homo sapiens_hsa051100.52936652
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.52654678
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52514191
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52222417
103Ras signaling pathway_Homo sapiens_hsa040140.52048260
104* TGF-beta signaling pathway_Homo sapiens_hsa043500.51600708
105Endometrial cancer_Homo sapiens_hsa052130.51322816
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49372498
107Wnt signaling pathway_Homo sapiens_hsa043100.49157656
108Rap1 signaling pathway_Homo sapiens_hsa040150.48983862
109Renal cell carcinoma_Homo sapiens_hsa052110.48152948
110Hedgehog signaling pathway_Homo sapiens_hsa043400.44854479
111Inositol phosphate metabolism_Homo sapiens_hsa005620.42408154
112AMPK signaling pathway_Homo sapiens_hsa041520.42124737
113Fatty acid metabolism_Homo sapiens_hsa012120.41692212
114Prion diseases_Homo sapiens_hsa050200.40358493
115Hippo signaling pathway_Homo sapiens_hsa043900.39316923
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39069972
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35913614
118Insulin resistance_Homo sapiens_hsa049310.35370800
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34745954
120Mineral absorption_Homo sapiens_hsa049780.34221355
121VEGF signaling pathway_Homo sapiens_hsa043700.34044161
122Glycerolipid metabolism_Homo sapiens_hsa005610.34042197
123PPAR signaling pathway_Homo sapiens_hsa033200.33210413
124Propanoate metabolism_Homo sapiens_hsa006400.33019138

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