ZG16B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.05068135
2negative regulation of bone mineralization (GO:0030502)5.03471584
3intestinal epithelial cell development (GO:0060576)4.90825377
4COPI coating of Golgi vesicle (GO:0048205)4.81499087
5Golgi transport vesicle coating (GO:0048200)4.81499087
6endothelial cell chemotaxis (GO:0035767)4.70513839
7negative regulation of biomineral tissue development (GO:0070168)4.49008988
8regulation of water loss via skin (GO:0033561)4.48867790
9O-glycan processing (GO:0016266)4.31690491
10GDP-mannose metabolic process (GO:0019673)4.03588724
11multicellular organismal water homeostasis (GO:0050891)4.01602956
12establishment of skin barrier (GO:0061436)3.93013562
13positive regulation of Cdc42 GTPase activity (GO:0043089)3.86122418
14iron ion import (GO:0097286)3.83056084
15* retina homeostasis (GO:0001895)3.82074868
16epithelial cell maturation (GO:0002070)3.60364111
17positive regulation of keratinocyte differentiation (GO:0045618)3.59036983
18glomerular filtration (GO:0003094)3.51806051
19proline biosynthetic process (GO:0006561)3.47750766
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.47705040
21water homeostasis (GO:0030104)3.40760787
22mammary gland epithelial cell differentiation (GO:0060644)3.36033153
23amyloid precursor protein catabolic process (GO:0042987)3.34721329
24cellular response to antibiotic (GO:0071236)3.34315123
25negative regulation of cell size (GO:0045792)3.26853750
26branching involved in mammary gland duct morphogenesis (GO:0060444)3.25902238
27maternal placenta development (GO:0001893)3.24209058
28renal filtration (GO:0097205)3.21431563
29primary alcohol catabolic process (GO:0034310)3.20443126
30glutathione biosynthetic process (GO:0006750)3.17524252
31positive regulation of epidermal cell differentiation (GO:0045606)3.14871734
32biotin metabolic process (GO:0006768)3.14597183
33retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.03557110
34sulfur amino acid catabolic process (GO:0000098)3.01688767
35calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.00301394
36antimicrobial humoral response (GO:0019730)3.00124301
37epithelial cell differentiation involved in prostate gland development (GO:0060742)2.99066219
38regulation of autophagic vacuole assembly (GO:2000785)2.98669481
39negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.92103392
40bundle of His cell to Purkinje myocyte communication (GO:0086069)2.91675219
41protein retention in ER lumen (GO:0006621)2.89801270
42complement activation, classical pathway (GO:0006958)2.88854629
43epithelial cell-cell adhesion (GO:0090136)2.87084610
44linoleic acid metabolic process (GO:0043651)2.85968917
45COPII vesicle coating (GO:0048208)2.83570079
46nonribosomal peptide biosynthetic process (GO:0019184)2.82756241
47keratinization (GO:0031424)2.82582958
48regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.81726038
49negative regulation of fatty acid transport (GO:2000192)2.81526786
50regulation of keratinocyte differentiation (GO:0045616)2.80926682
51peptide cross-linking (GO:0018149)2.80288224
52endocrine hormone secretion (GO:0060986)2.79636983
53ethanol metabolic process (GO:0006067)2.79618289
54lipoxygenase pathway (GO:0019372)2.77397087
55digestive system process (GO:0022600)2.77325725
56phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.76638798
57antibacterial humoral response (GO:0019731)2.76539325
58response to food (GO:0032094)2.75925809
59protein O-linked glycosylation (GO:0006493)2.74780683
60axonemal dynein complex assembly (GO:0070286)2.71765022
61negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.70996530
62regulation of respiratory burst (GO:0060263)2.68139535
63macroautophagy (GO:0016236)2.67772833
64maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.64271818
65one-carbon compound transport (GO:0019755)2.63095653
66regulation of vacuole organization (GO:0044088)2.56432782
67secretion by tissue (GO:0032941)2.52955993
68NADH metabolic process (GO:0006734)2.51988475
69interferon-gamma secretion (GO:0072643)2.49211500
70ear development (GO:0043583)2.48085646
71regulation of viral release from host cell (GO:1902186)2.46345917
72exocrine pancreas development (GO:0031017)2.42507623
73angiotensin maturation (GO:0002003)2.42052818
74insulin-like growth factor receptor signaling pathway (GO:0048009)2.41610158
75complement activation (GO:0006956)2.41374561
76maintenance of gastrointestinal epithelium (GO:0030277)2.40790857
77regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.40609094
78regulation of chemokine secretion (GO:0090196)2.38042227
79amyloid precursor protein metabolic process (GO:0042982)2.37664461
80alpha-linolenic acid metabolic process (GO:0036109)2.36223393
81positive regulation of chemokine secretion (GO:0090197)2.35660521
82peptidyl-tyrosine autophosphorylation (GO:0038083)2.34743631
83nitric oxide biosynthetic process (GO:0006809)2.33553356
84body fluid secretion (GO:0007589)2.33476400
85regulation of interleukin-13 production (GO:0032656)2.32756738
86diol metabolic process (GO:0034311)2.32602679
87hepatocyte apoptotic process (GO:0097284)2.32146032
88regulation of fatty acid beta-oxidation (GO:0031998)2.31050499
89positive regulation of respiratory burst (GO:0060267)2.30828316
90regulation of receptor binding (GO:1900120)2.30739180
91purine nucleotide transport (GO:0015865)2.28543970
92regulation of glucose import in response to insulin stimulus (GO:2001273)2.28364741
93proline metabolic process (GO:0006560)2.27989368
94positive regulation of epidermis development (GO:0045684)2.24842730
95ruffle organization (GO:0031529)2.23982035
96dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.22180598
97glutamine family amino acid biosynthetic process (GO:0009084)2.21702297
98negative regulation of viral release from host cell (GO:1902187)2.19396406
99regulation of cholesterol biosynthetic process (GO:0045540)2.18315256
100negative regulation of kidney development (GO:0090185)2.18208198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR2_21235772_ChIP-Seq_MCF-7_Human4.23864218
2ESR1_20079471_ChIP-ChIP_T-47D_Human4.21173289
3ESR1_21235772_ChIP-Seq_MCF-7_Human4.01709130
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.74047186
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.70750137
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.61940908
7ZNF263_19887448_ChIP-Seq_K562_Human3.15795729
8RACK7_27058665_Chip-Seq_MCF-7_Human2.80816346
9TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.52713311
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50814889
11ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.42919746
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.42613003
13RUNX1_27514584_Chip-Seq_MCF-7_Human2.35940349
14LXR_22292898_ChIP-Seq_THP-1_Human2.27881901
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.13925453
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.02506422
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.90162773
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88813517
19SOX2_27498859_Chip-Seq_STOMACH_Mouse1.88640883
20PPARA_22158963_ChIP-Seq_LIVER_Mouse1.87777595
21KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.83544968
22RXR_22158963_ChIP-Seq_LIVER_Mouse1.75893626
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73026201
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71480939
25GATA3_24758297_ChIP-Seq_MCF-7_Human1.70370680
26VDR_21846776_ChIP-Seq_THP-1_Human1.70146821
27SOX2_20726797_ChIP-Seq_SW620_Human1.66201121
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.64557203
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.64325108
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59251056
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.56430363
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55660196
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.55642935
34CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.52912142
35CLOCK_20551151_ChIP-Seq_293T_Human1.51707619
36P63_26484246_Chip-Seq_KERATINOCYTES_Human1.51354449
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50561587
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.47960390
39GATA6_25053715_ChIP-Seq_YYC3_Human1.47696584
40SMC4_20622854_ChIP-Seq_HELA_Human1.44448915
41CREB1_26743006_Chip-Seq_LNCaP_Human1.42679430
42ATF3_27146783_Chip-Seq_COLON_Human1.39695225
43TCF7_22412390_ChIP-Seq_EML_Mouse1.39452539
44FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.39123566
45P68_20966046_ChIP-Seq_HELA_Human1.38335920
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34282027
47CDX2_20551321_ChIP-Seq_CACO-2_Human1.33436012
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32782307
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29127815
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28731941
51ELF5_23300383_ChIP-Seq_T47D_Human1.27640573
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26073254
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24554310
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23589352
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21779863
56BCOR_27268052_Chip-Seq_Bcells_Human1.21663040
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.21063676
58AHR_22903824_ChIP-Seq_MCF-7_Human1.18115331
59KLF5_25053715_ChIP-Seq_YYC3_Human1.16615265
60CHD1_26751641_Chip-Seq_LNCaP_Human1.16375660
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.15410444
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12636392
63VDR_24763502_ChIP-Seq_THP-1_Human1.12597843
64* GATA4_25053715_ChIP-Seq_YYC3_Human1.12478122
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08462858
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08096954
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08096954
68STAT1_20625510_ChIP-Seq_HELA_Human1.07682456
69TP63_22573176_ChIP-Seq_HFKS_Human1.07457641
70LXR_22158963_ChIP-Seq_LIVER_Mouse1.07296361
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.07094856
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.07052530
73BCL6_27268052_Chip-Seq_Bcells_Human1.06832789
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05789525
75SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05417961
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03389445
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03221948
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02826457
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02578712
80KDM2B_26808549_Chip-Seq_DND41_Human0.99004339
81SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98523574
82SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98344451
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97831395
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97359134
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97093363
86FOXA1_25552417_ChIP-Seq_VCAP_Human0.96923889
87MYC_22102868_ChIP-Seq_BL_Human0.96228568
88* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96190189
89ERG_21242973_ChIP-ChIP_JURKAT_Human0.95087604
90CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95067058
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94224690
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94200108
93AR_21909140_ChIP-Seq_LNCAP_Human0.94187844
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93978560
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93461483
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89780547
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88223501
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87695596
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86613253
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86331589

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.77043254
2MP0004264_abnormal_extraembryonic_tissu4.10386097
3MP0002796_impaired_skin_barrier3.76729618
4MP0003705_abnormal_hypodermis_morpholog2.97453380
5MP0002166_altered_tumor_susceptibility2.58445288
6MP0005275_abnormal_skin_tensile2.45958985
7MP0001873_stomach_inflammation2.41297358
8MP0002098_abnormal_vibrissa_morphology2.26512829
9MP0003191_abnormal_cellular_cholesterol2.18703093
10MP0003724_increased_susceptibility_to2.11488348
11MP0002009_preneoplasia2.02014718
12MP0005083_abnormal_biliary_tract2.00520366
13MP0009780_abnormal_chondrocyte_physiolo2.00003106
14MP0005501_abnormal_skin_physiology1.96902907
15MP0003183_abnormal_peptide_metabolism1.93837542
16MP0005058_abnormal_lysosome_morphology1.91476611
17MP0010678_abnormal_skin_adnexa1.87810231
18MP0004858_abnormal_nervous_system1.85632210
19MP0005451_abnormal_body_composition1.83402309
20MP0004947_skin_inflammation1.78773346
21MP0002006_tumorigenesis1.67799803
22MP0010155_abnormal_intestine_physiology1.67459719
23MP0003453_abnormal_keratinocyte_physiol1.67286357
24MP0001881_abnormal_mammary_gland1.67145432
25MP0005670_abnormal_white_adipose1.60720899
26MP0000678_abnormal_parathyroid_gland1.58320144
27MP0000627_abnormal_mammary_gland1.54580507
28MP0001216_abnormal_epidermal_layer1.52924468
29MP0001765_abnormal_ion_homeostasis1.47169010
30MP0005310_abnormal_salivary_gland1.45021032
31MP0000377_abnormal_hair_follicle1.43864395
32MP0004043_abnormal_pH_regulation1.42677958
33MP0001346_abnormal_lacrimal_gland1.29870913
34MP0004381_abnormal_hair_follicle1.24602346
35MP0004782_abnormal_surfactant_physiolog1.23833368
36MP0005666_abnormal_adipose_tissue1.23302275
37MP0009840_abnormal_foam_cell1.22539441
38MP0001666_abnormal_nutrient_absorption1.19938701
39MP0000467_abnormal_esophagus_morphology1.19663031
40MP0004185_abnormal_adipocyte_glucose1.19035633
41MP0002060_abnormal_skin_morphology1.17949445
42MP0003436_decreased_susceptibility_to1.16860218
43MP0005360_urolithiasis1.15202395
44MP0009643_abnormal_urine_homeostasis1.14670152
45MP0003566_abnormal_cell_adhesion1.11788658
46MP0005409_darkened_coat_color1.11621988
47MP0005248_abnormal_Harderian_gland1.11481424
48MP0001664_abnormal_digestion1.10668301
49MP0001533_abnormal_skeleton_physiology1.10222785
50MP0005647_abnormal_sex_gland1.08915060
51MP0005636_abnormal_mineral_homeostasis1.05047001
52MP0003638_abnormal_response/metabolism_1.04778533
53MP0009931_abnormal_skin_appearance1.03146630
54MP0000858_altered_metastatic_potential1.01745602
55MP0000383_abnormal_hair_follicle1.01668444
56MP0000681_abnormal_thyroid_gland1.01318656
57MP0005076_abnormal_cell_differentiation1.01310000
58MP0005365_abnormal_bile_salt0.98969494
59MP0010771_integument_phenotype0.97847887
60MP0001756_abnormal_urination0.97341191
61MP0002896_abnormal_bone_mineralization0.93204747
62MP0000465_gastrointestinal_hemorrhage0.92787039
63MP0003866_abnormal_defecation0.91565920
64MP0000367_abnormal_coat/_hair0.90119396
65MP0003045_fibrosis0.90089094
66MP0003075_altered_response_to0.89566848
67MP0005165_increased_susceptibility_to0.89206771
68MP0005025_abnormal_response_to0.85849342
69MP0008875_abnormal_xenobiotic_pharmacok0.84236602
70MP0002933_joint_inflammation0.84194999
71MP0000613_abnormal_salivary_gland0.83815978
72MP0000538_abnormal_urinary_bladder0.83491360
73MP0005503_abnormal_tendon_morphology0.83402230
74MP0005166_decreased_susceptibility_to0.82507154
75MP0001849_ear_inflammation0.82034364
76MP0008260_abnormal_autophagy0.81808577
77MP0002148_abnormal_hypersensitivity_rea0.81499982
78MP0004019_abnormal_vitamin_homeostasis0.79977292
79MP0001919_abnormal_reproductive_system0.78373662
80MP0000470_abnormal_stomach_morphology0.78351589
81MP0001851_eye_inflammation0.76488586
82MP0001845_abnormal_inflammatory_respons0.76131558
83MP0003303_peritoneal_inflammation0.76008211
84MP0000427_abnormal_hair_cycle0.75064267
85MP0005408_hypopigmentation0.73275215
86MP0002108_abnormal_muscle_morphology0.73083015
87MP0000477_abnormal_intestine_morphology0.72520374
88MP0002277_abnormal_respiratory_mucosa0.71702933
89MP0002254_reproductive_system_inflammat0.71077045
90MP0005375_adipose_tissue_phenotype0.70402452
91MP0001243_abnormal_dermal_layer0.70150299
92MP0002136_abnormal_kidney_physiology0.69657740
93MP0000609_abnormal_liver_physiology0.67436381
94MP0003315_abnormal_perineum_morphology0.66687361
95MP0003123_paternal_imprinting0.65905979
96MP0001727_abnormal_embryo_implantation0.65427859
97MP0005646_abnormal_pituitary_gland0.65233181
98MP0002249_abnormal_larynx_morphology0.64401260
99MP0000462_abnormal_digestive_system0.64233910
100MP0003936_abnormal_reproductive_system0.64115013

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)3.99696658
2Flat acetabular roof (HP:0003180)3.77865800
3Hyperactive renin-angiotensin system (HP:0000841)3.55545185
4Chronic bronchitis (HP:0004469)3.45764013
5Distal lower limb muscle weakness (HP:0009053)3.41052175
6Increased IgE level (HP:0003212)3.29303625
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.28108854
8Pili torti (HP:0003777)3.28045121
9Sparse lateral eyebrow (HP:0005338)3.21034778
10Thin bony cortex (HP:0002753)3.19307898
11Nasal polyposis (HP:0100582)3.13020264
12Systemic lupus erythematosus (HP:0002725)2.99564354
13Abnormality of the nasal mucosa (HP:0000433)2.98051576
14Congenital ichthyosiform erythroderma (HP:0007431)2.77510367
15Glomerulonephritis (HP:0000099)2.77286381
16Acanthosis nigricans (HP:0000956)2.75213584
17Abnormality of the distal phalanges of the toes (HP:0010182)2.63867760
18Bulbar palsy (HP:0001283)2.58837478
19Esophageal varix (HP:0002040)2.58346451
20Deep venous thrombosis (HP:0002625)2.54278451
21Lip pit (HP:0100267)2.48074215
22Germ cell neoplasia (HP:0100728)2.46972531
23Complement deficiency (HP:0004431)2.44489710
24Amelogenesis imperfecta (HP:0000705)2.42212718
25Asymmetry of the thorax (HP:0001555)2.41090465
26Dysostosis multiplex (HP:0000943)2.38293800
27Abnormal hair laboratory examination (HP:0003328)2.36241724
28Rhinitis (HP:0012384)2.35654316
29Abnormality of nail color (HP:0100643)2.35075236
30Ulnar claw (HP:0001178)2.32644401
31Abnormality of small intestinal villus morphology (HP:0011472)2.32374175
32Villous atrophy (HP:0011473)2.32374175
33Oligomenorrhea (HP:0000876)2.32050117
34Abnormality of complement system (HP:0005339)2.30673322
35Growth hormone excess (HP:0000845)2.29308734
36Abnormal tarsal ossification (HP:0008369)2.27974630
37Nephritis (HP:0000123)2.26709723
38J-shaped sella turcica (HP:0002680)2.26590333
39Bronchitis (HP:0012387)2.25605698
40Mucopolysacchariduria (HP:0008155)2.25306339
41Urinary glycosaminoglycan excretion (HP:0003541)2.25306339
42Hyperkalemia (HP:0002153)2.22526365
43Malnutrition (HP:0004395)2.18998847
44Abnormality of monocarboxylic acid metabolism (HP:0010996)2.18565384
45Cervical subluxation (HP:0003308)2.18337431
46Hyperparathyroidism (HP:0000843)2.17890476
47Decreased circulating renin level (HP:0003351)2.17887360
48Hemorrhage of the eye (HP:0011885)2.17565069
49Testicular neoplasm (HP:0010788)2.17125787
50Concave nail (HP:0001598)2.16412739
51Abnormal respiratory motile cilium physiology (HP:0012261)2.14440096
52Myopathic facies (HP:0002058)2.12689167
53Hypotrichosis (HP:0001006)2.11759894
54Diaphragmatic weakness (HP:0009113)2.07907416
55Renal salt wasting (HP:0000127)2.05330405
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04843192
57Abnormality of polysaccharide metabolism (HP:0011012)2.04843192
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04843192
59Spinal cord compression (HP:0002176)2.04492912
60Vertebral compression fractures (HP:0002953)2.04299698
61Bronchiectasis (HP:0002110)2.04242289
62Erythema (HP:0010783)1.99946863
63Woolly hair (HP:0002224)1.99570922
64Seborrheic dermatitis (HP:0001051)1.99413252
65Septate vagina (HP:0001153)1.98594785
66Increased cerebral lipofuscin (HP:0011813)1.98253090
67Abnormality of carpal bone ossification (HP:0006257)1.97304861
68Loss of speech (HP:0002371)1.97266536
69Increased neuronal autofluorescent lipopigment (HP:0002074)1.97106551
70Abnormal respiratory epithelium morphology (HP:0012253)1.96974659
71Abnormal respiratory motile cilium morphology (HP:0005938)1.96974659
72Visceral angiomatosis (HP:0100761)1.95686595
73Pigmentary retinal degeneration (HP:0001146)1.94746545
74Lymphangioma (HP:0100764)1.92800722
75Testicular atrophy (HP:0000029)1.90639565
76Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.89927352
77Hyporeflexia of lower limbs (HP:0002600)1.89234096
78Axonal loss (HP:0003447)1.88231885
79Hyperammonemia (HP:0001987)1.85919930
80Flattened epiphyses (HP:0003071)1.85630725
81Abdominal distention (HP:0003270)1.85430011
82Infertility (HP:0000789)1.84920727
83Colitis (HP:0002583)1.84409927
84Alopecia of scalp (HP:0002293)1.83280612
85Segmental peripheral demyelination/remyelination (HP:0003481)1.81705890
86Cone-rod dystrophy (HP:0000548)1.81114061
87Neoplasm of the heart (HP:0100544)1.79509848
88Vacuolated lymphocytes (HP:0001922)1.78648974
89Intrahepatic cholestasis (HP:0001406)1.77213831
90Dehydration (HP:0001944)1.77153337
91Stroke (HP:0001297)1.77060308
92Hemangiomatosis (HP:0007461)1.74752490
93Advanced eruption of teeth (HP:0006288)1.74044029
94Eczematoid dermatitis (HP:0000976)1.72923786
95Congenital glaucoma (HP:0001087)1.71616801
96Interstitial pulmonary disease (HP:0006530)1.70804485
97Short nail (HP:0001799)1.68831898
98Bone pain (HP:0002653)1.68543616
99Insidious onset (HP:0003587)1.68303014
100Termporal pattern (HP:0011008)1.68303014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.94119523
2EPHA25.30608590
3MAPKAPK33.57250911
4PKN23.36260460
5ERN12.88862330
6TESK12.86685288
7EEF2K2.81091192
8SIK12.52662359
9RPS6KB22.27608730
10MST1R2.23144057
11MAP3K32.05186871
12SMG11.92164235
13MAPK151.87923728
14RIPK11.81709560
15NME21.80532572
16MUSK1.74069427
17SCYL21.67827035
18FER1.61378827
19PTK61.54663603
20PIK3CA1.51495596
21TBK11.50922662
22LRRK21.49876075
23TESK21.44926419
24ICK1.28375879
25NEK61.25786637
26IRAK31.23299368
27FGFR41.23228007
28ILK1.22731463
29MAP2K21.22645204
30PAK41.21850577
31PIM21.05555814
32TNK21.01664626
33AKT30.99967466
34MAP2K30.98733205
35STK390.97628040
36TAOK10.97318995
37MST40.97083779
38PRKD30.96344797
39MAP3K120.93874933
40PRKCI0.92513035
41GRK60.91058725
42HIPK20.84289274
43PDPK10.83917642
44RPS6KA20.82814748
45LMTK20.82645437
46EPHB10.82331167
47MYLK0.81833546
48BCKDK0.81312944
49ARAF0.80007329
50EPHA30.78137824
51BMPR20.77904610
52IKBKE0.76604892
53CHUK0.75731247
54RET0.70487382
55MAP3K110.69498843
56DMPK0.67620808
57MAP3K10.67381526
58MAPKAPK20.67162579
59OBSCN0.66392486
60TRPM70.63603180
61IKBKB0.62749493
62BLK0.61727773
63MTOR0.61557461
64PRKD20.58744727
65TAOK20.58073830
66CDK70.56021778
67PRKD10.54909381
68MET0.54286035
69MAP2K10.53365736
70RPS6KC10.51655779
71RPS6KL10.51655779
72CAMK1D0.46722959
73MAP3K140.45064830
74ZAP700.43062380
75STK240.42539269
76PRPF4B0.42309945
77MATK0.41162600
78LIMK10.40927460
79PTK20.40719492
80VRK20.40323192
81MAP3K20.37948214
82RPS6KA60.37771709
83MAP2K60.37640689
84PDK10.36971719
85RIPK40.34615740
86PRKAA20.34410832
87MAP4K10.33482225
88JAK10.31446751
89PRKG20.31385641
90DDR20.30806439
91JAK20.30735934
92MAP3K60.30023061
93CAMK2G0.29527646
94CDC42BPA0.29221810
95STK380.28632125
96CSK0.28355043
97CDK90.28059121
98EPHB20.27652021
99TYK20.27459499
100DYRK1B0.27109004

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.33033586
2Phenylalanine metabolism_Homo sapiens_hsa003602.76926937
3Other glycan degradation_Homo sapiens_hsa005112.45518532
4Fructose and mannose metabolism_Homo sapiens_hsa000512.24833363
5Fatty acid biosynthesis_Homo sapiens_hsa000612.18816487
6Sulfur metabolism_Homo sapiens_hsa009202.18590039
7Salivary secretion_Homo sapiens_hsa049702.05812676
8Histidine metabolism_Homo sapiens_hsa003402.00033937
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77498116
10Arginine biosynthesis_Homo sapiens_hsa002201.73545610
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.64378933
12Vibrio cholerae infection_Homo sapiens_hsa051101.61034179
13Tyrosine metabolism_Homo sapiens_hsa003501.56565963
14Glutathione metabolism_Homo sapiens_hsa004801.54314685
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.53391056
16Sphingolipid metabolism_Homo sapiens_hsa006001.51174621
17Lysosome_Homo sapiens_hsa041421.49081143
18Renin-angiotensin system_Homo sapiens_hsa046141.46036159
19Caffeine metabolism_Homo sapiens_hsa002321.42867206
20Hepatitis C_Homo sapiens_hsa051601.41318485
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41139430
22Vitamin digestion and absorption_Homo sapiens_hsa049771.40067565
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36026305
24Staphylococcus aureus infection_Homo sapiens_hsa051501.34466413
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33256402
26Acute myeloid leukemia_Homo sapiens_hsa052211.26203316
27Galactose metabolism_Homo sapiens_hsa000521.23604033
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17962093
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14708738
30Asthma_Homo sapiens_hsa053101.13773805
31PPAR signaling pathway_Homo sapiens_hsa033201.13226590
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05901120
33TNF signaling pathway_Homo sapiens_hsa046681.05007959
34Chemical carcinogenesis_Homo sapiens_hsa052041.04123483
35Mineral absorption_Homo sapiens_hsa049781.02977354
36Insulin resistance_Homo sapiens_hsa049311.01547328
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.00525453
38Leukocyte transendothelial migration_Homo sapiens_hsa046700.97932282
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96096593
40Sulfur relay system_Homo sapiens_hsa041220.92751877
41VEGF signaling pathway_Homo sapiens_hsa043700.90440374
42Prolactin signaling pathway_Homo sapiens_hsa049170.90133305
43Arginine and proline metabolism_Homo sapiens_hsa003300.88544907
44Influenza A_Homo sapiens_hsa051640.87704302
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86243609
46Fatty acid metabolism_Homo sapiens_hsa012120.85297658
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84061998
48Prostate cancer_Homo sapiens_hsa052150.83594618
49Endometrial cancer_Homo sapiens_hsa052130.82540756
50Fatty acid degradation_Homo sapiens_hsa000710.81919833
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80705423
52beta-Alanine metabolism_Homo sapiens_hsa004100.80408445
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79121175
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77179325
55Pentose phosphate pathway_Homo sapiens_hsa000300.76061938
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75578616
57Thyroid cancer_Homo sapiens_hsa052160.75559083
58Amoebiasis_Homo sapiens_hsa051460.75502086
59Fatty acid elongation_Homo sapiens_hsa000620.74202603
60Legionellosis_Homo sapiens_hsa051340.73435642
61Tight junction_Homo sapiens_hsa045300.70539314
62Notch signaling pathway_Homo sapiens_hsa043300.70519390
63B cell receptor signaling pathway_Homo sapiens_hsa046620.69786352
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69641116
65Leishmaniasis_Homo sapiens_hsa051400.69565216
66AMPK signaling pathway_Homo sapiens_hsa041520.69525122
67Estrogen signaling pathway_Homo sapiens_hsa049150.69313707
68Allograft rejection_Homo sapiens_hsa053300.67789521
69ABC transporters_Homo sapiens_hsa020100.67724838
70Toxoplasmosis_Homo sapiens_hsa051450.66077960
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65863225
72Peroxisome_Homo sapiens_hsa041460.65651461
73Pertussis_Homo sapiens_hsa051330.63827442
74Bladder cancer_Homo sapiens_hsa052190.62812091
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62475602
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62256280
77Collecting duct acid secretion_Homo sapiens_hsa049660.61536999
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.61473564
79Endocytosis_Homo sapiens_hsa041440.61227148
80Complement and coagulation cascades_Homo sapiens_hsa046100.60952392
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60923129
82Arachidonic acid metabolism_Homo sapiens_hsa005900.59874166
83Insulin signaling pathway_Homo sapiens_hsa049100.58491334
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57231635
85Non-small cell lung cancer_Homo sapiens_hsa052230.56993859
86Rheumatoid arthritis_Homo sapiens_hsa053230.56323477
87Biosynthesis of amino acids_Homo sapiens_hsa012300.55695710
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55321405
89Prion diseases_Homo sapiens_hsa050200.54098006
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53667576
91Autoimmune thyroid disease_Homo sapiens_hsa053200.53633272
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.53196300
93mTOR signaling pathway_Homo sapiens_hsa041500.52449256
94N-Glycan biosynthesis_Homo sapiens_hsa005100.50011259
95Osteoclast differentiation_Homo sapiens_hsa043800.49655202
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.48964734
97Chronic myeloid leukemia_Homo sapiens_hsa052200.48763840
98Tuberculosis_Homo sapiens_hsa051520.48700375
99Choline metabolism in cancer_Homo sapiens_hsa052310.47947871
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47513767

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