Rank | Gene Set | Z-score |
---|---|---|
1 | desmosome organization (GO:0002934) | 6.05068135 |
2 | negative regulation of bone mineralization (GO:0030502) | 5.03471584 |
3 | intestinal epithelial cell development (GO:0060576) | 4.90825377 |
4 | COPI coating of Golgi vesicle (GO:0048205) | 4.81499087 |
5 | Golgi transport vesicle coating (GO:0048200) | 4.81499087 |
6 | endothelial cell chemotaxis (GO:0035767) | 4.70513839 |
7 | negative regulation of biomineral tissue development (GO:0070168) | 4.49008988 |
8 | regulation of water loss via skin (GO:0033561) | 4.48867790 |
9 | O-glycan processing (GO:0016266) | 4.31690491 |
10 | GDP-mannose metabolic process (GO:0019673) | 4.03588724 |
11 | multicellular organismal water homeostasis (GO:0050891) | 4.01602956 |
12 | establishment of skin barrier (GO:0061436) | 3.93013562 |
13 | positive regulation of Cdc42 GTPase activity (GO:0043089) | 3.86122418 |
14 | iron ion import (GO:0097286) | 3.83056084 |
15 | * retina homeostasis (GO:0001895) | 3.82074868 |
16 | epithelial cell maturation (GO:0002070) | 3.60364111 |
17 | positive regulation of keratinocyte differentiation (GO:0045618) | 3.59036983 |
18 | glomerular filtration (GO:0003094) | 3.51806051 |
19 | proline biosynthetic process (GO:0006561) | 3.47750766 |
20 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 3.47705040 |
21 | water homeostasis (GO:0030104) | 3.40760787 |
22 | mammary gland epithelial cell differentiation (GO:0060644) | 3.36033153 |
23 | amyloid precursor protein catabolic process (GO:0042987) | 3.34721329 |
24 | cellular response to antibiotic (GO:0071236) | 3.34315123 |
25 | negative regulation of cell size (GO:0045792) | 3.26853750 |
26 | branching involved in mammary gland duct morphogenesis (GO:0060444) | 3.25902238 |
27 | maternal placenta development (GO:0001893) | 3.24209058 |
28 | renal filtration (GO:0097205) | 3.21431563 |
29 | primary alcohol catabolic process (GO:0034310) | 3.20443126 |
30 | glutathione biosynthetic process (GO:0006750) | 3.17524252 |
31 | positive regulation of epidermal cell differentiation (GO:0045606) | 3.14871734 |
32 | biotin metabolic process (GO:0006768) | 3.14597183 |
33 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 3.03557110 |
34 | sulfur amino acid catabolic process (GO:0000098) | 3.01688767 |
35 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338) | 3.00301394 |
36 | antimicrobial humoral response (GO:0019730) | 3.00124301 |
37 | epithelial cell differentiation involved in prostate gland development (GO:0060742) | 2.99066219 |
38 | regulation of autophagic vacuole assembly (GO:2000785) | 2.98669481 |
39 | negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067) | 2.92103392 |
40 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 2.91675219 |
41 | protein retention in ER lumen (GO:0006621) | 2.89801270 |
42 | complement activation, classical pathway (GO:0006958) | 2.88854629 |
43 | epithelial cell-cell adhesion (GO:0090136) | 2.87084610 |
44 | linoleic acid metabolic process (GO:0043651) | 2.85968917 |
45 | COPII vesicle coating (GO:0048208) | 2.83570079 |
46 | nonribosomal peptide biosynthetic process (GO:0019184) | 2.82756241 |
47 | keratinization (GO:0031424) | 2.82582958 |
48 | regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358) | 2.81726038 |
49 | negative regulation of fatty acid transport (GO:2000192) | 2.81526786 |
50 | regulation of keratinocyte differentiation (GO:0045616) | 2.80926682 |
51 | peptide cross-linking (GO:0018149) | 2.80288224 |
52 | endocrine hormone secretion (GO:0060986) | 2.79636983 |
53 | ethanol metabolic process (GO:0006067) | 2.79618289 |
54 | lipoxygenase pathway (GO:0019372) | 2.77397087 |
55 | digestive system process (GO:0022600) | 2.77325725 |
56 | phospholipase C-activating dopamine receptor signaling pathway (GO:0060158) | 2.76638798 |
57 | antibacterial humoral response (GO:0019731) | 2.76539325 |
58 | response to food (GO:0032094) | 2.75925809 |
59 | protein O-linked glycosylation (GO:0006493) | 2.74780683 |
60 | axonemal dynein complex assembly (GO:0070286) | 2.71765022 |
61 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 2.70996530 |
62 | regulation of respiratory burst (GO:0060263) | 2.68139535 |
63 | macroautophagy (GO:0016236) | 2.67772833 |
64 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.64271818 |
65 | one-carbon compound transport (GO:0019755) | 2.63095653 |
66 | regulation of vacuole organization (GO:0044088) | 2.56432782 |
67 | secretion by tissue (GO:0032941) | 2.52955993 |
68 | NADH metabolic process (GO:0006734) | 2.51988475 |
69 | interferon-gamma secretion (GO:0072643) | 2.49211500 |
70 | ear development (GO:0043583) | 2.48085646 |
71 | regulation of viral release from host cell (GO:1902186) | 2.46345917 |
72 | exocrine pancreas development (GO:0031017) | 2.42507623 |
73 | angiotensin maturation (GO:0002003) | 2.42052818 |
74 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 2.41610158 |
75 | complement activation (GO:0006956) | 2.41374561 |
76 | maintenance of gastrointestinal epithelium (GO:0030277) | 2.40790857 |
77 | regulation of branching involved in prostate gland morphogenesis (GO:0060687) | 2.40609094 |
78 | regulation of chemokine secretion (GO:0090196) | 2.38042227 |
79 | amyloid precursor protein metabolic process (GO:0042982) | 2.37664461 |
80 | alpha-linolenic acid metabolic process (GO:0036109) | 2.36223393 |
81 | positive regulation of chemokine secretion (GO:0090197) | 2.35660521 |
82 | peptidyl-tyrosine autophosphorylation (GO:0038083) | 2.34743631 |
83 | nitric oxide biosynthetic process (GO:0006809) | 2.33553356 |
84 | body fluid secretion (GO:0007589) | 2.33476400 |
85 | regulation of interleukin-13 production (GO:0032656) | 2.32756738 |
86 | diol metabolic process (GO:0034311) | 2.32602679 |
87 | hepatocyte apoptotic process (GO:0097284) | 2.32146032 |
88 | regulation of fatty acid beta-oxidation (GO:0031998) | 2.31050499 |
89 | positive regulation of respiratory burst (GO:0060267) | 2.30828316 |
90 | regulation of receptor binding (GO:1900120) | 2.30739180 |
91 | purine nucleotide transport (GO:0015865) | 2.28543970 |
92 | regulation of glucose import in response to insulin stimulus (GO:2001273) | 2.28364741 |
93 | proline metabolic process (GO:0006560) | 2.27989368 |
94 | positive regulation of epidermis development (GO:0045684) | 2.24842730 |
95 | ruffle organization (GO:0031529) | 2.23982035 |
96 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 2.22180598 |
97 | glutamine family amino acid biosynthetic process (GO:0009084) | 2.21702297 |
98 | negative regulation of viral release from host cell (GO:1902187) | 2.19396406 |
99 | regulation of cholesterol biosynthetic process (GO:0045540) | 2.18315256 |
100 | negative regulation of kidney development (GO:0090185) | 2.18208198 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 4.23864218 |
2 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 4.21173289 |
3 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 4.01709130 |
4 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.74047186 |
5 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 3.70750137 |
6 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 3.61940908 |
7 | ZNF263_19887448_ChIP-Seq_K562_Human | 3.15795729 |
8 | RACK7_27058665_Chip-Seq_MCF-7_Human | 2.80816346 |
9 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 2.52713311 |
10 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.50814889 |
11 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 2.42919746 |
12 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.42613003 |
13 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 2.35940349 |
14 | LXR_22292898_ChIP-Seq_THP-1_Human | 2.27881901 |
15 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.13925453 |
16 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 2.02506422 |
17 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.90162773 |
18 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.88813517 |
19 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.88640883 |
20 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.87777595 |
21 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.83544968 |
22 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.75893626 |
23 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.73026201 |
24 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.71480939 |
25 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 1.70370680 |
26 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.70146821 |
27 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.66201121 |
28 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.64557203 |
29 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.64325108 |
30 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.59251056 |
31 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.56430363 |
32 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.55660196 |
33 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.55642935 |
34 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.52912142 |
35 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.51707619 |
36 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.51354449 |
37 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.50561587 |
38 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.47960390 |
39 | GATA6_25053715_ChIP-Seq_YYC3_Human | 1.47696584 |
40 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.44448915 |
41 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.42679430 |
42 | ATF3_27146783_Chip-Seq_COLON_Human | 1.39695225 |
43 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.39452539 |
44 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.39123566 |
45 | P68_20966046_ChIP-Seq_HELA_Human | 1.38335920 |
46 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.34282027 |
47 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.33436012 |
48 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.32782307 |
49 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.29127815 |
50 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.28731941 |
51 | ELF5_23300383_ChIP-Seq_T47D_Human | 1.27640573 |
52 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.26073254 |
53 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.24554310 |
54 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.23589352 |
55 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.21779863 |
56 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.21663040 |
57 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.21063676 |
58 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.18115331 |
59 | KLF5_25053715_ChIP-Seq_YYC3_Human | 1.16615265 |
60 | CHD1_26751641_Chip-Seq_LNCaP_Human | 1.16375660 |
61 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.15410444 |
62 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.12636392 |
63 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.12597843 |
64 | * GATA4_25053715_ChIP-Seq_YYC3_Human | 1.12478122 |
65 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.08462858 |
66 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.08096954 |
67 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.08096954 |
68 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.07682456 |
69 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.07457641 |
70 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.07296361 |
71 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 1.07094856 |
72 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.07052530 |
73 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.06832789 |
74 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.05789525 |
75 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.05417961 |
76 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.03389445 |
77 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.03221948 |
78 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.02826457 |
79 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.02578712 |
80 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.99004339 |
81 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.98523574 |
82 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.98344451 |
83 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.97831395 |
84 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.97359134 |
85 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.97093363 |
86 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.96923889 |
87 | MYC_22102868_ChIP-Seq_BL_Human | 0.96228568 |
88 | * PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.96190189 |
89 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.95087604 |
90 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.95067058 |
91 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.94224690 |
92 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.94200108 |
93 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.94187844 |
94 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.93978560 |
95 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.93461483 |
96 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.89780547 |
97 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 0.88223501 |
98 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.87695596 |
99 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.86613253 |
100 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.86331589 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0010234_abnormal_vibrissa_follicle | 6.77043254 |
2 | MP0004264_abnormal_extraembryonic_tissu | 4.10386097 |
3 | MP0002796_impaired_skin_barrier | 3.76729618 |
4 | MP0003705_abnormal_hypodermis_morpholog | 2.97453380 |
5 | MP0002166_altered_tumor_susceptibility | 2.58445288 |
6 | MP0005275_abnormal_skin_tensile | 2.45958985 |
7 | MP0001873_stomach_inflammation | 2.41297358 |
8 | MP0002098_abnormal_vibrissa_morphology | 2.26512829 |
9 | MP0003191_abnormal_cellular_cholesterol | 2.18703093 |
10 | MP0003724_increased_susceptibility_to | 2.11488348 |
11 | MP0002009_preneoplasia | 2.02014718 |
12 | MP0005083_abnormal_biliary_tract | 2.00520366 |
13 | MP0009780_abnormal_chondrocyte_physiolo | 2.00003106 |
14 | MP0005501_abnormal_skin_physiology | 1.96902907 |
15 | MP0003183_abnormal_peptide_metabolism | 1.93837542 |
16 | MP0005058_abnormal_lysosome_morphology | 1.91476611 |
17 | MP0010678_abnormal_skin_adnexa | 1.87810231 |
18 | MP0004858_abnormal_nervous_system | 1.85632210 |
19 | MP0005451_abnormal_body_composition | 1.83402309 |
20 | MP0004947_skin_inflammation | 1.78773346 |
21 | MP0002006_tumorigenesis | 1.67799803 |
22 | MP0010155_abnormal_intestine_physiology | 1.67459719 |
23 | MP0003453_abnormal_keratinocyte_physiol | 1.67286357 |
24 | MP0001881_abnormal_mammary_gland | 1.67145432 |
25 | MP0005670_abnormal_white_adipose | 1.60720899 |
26 | MP0000678_abnormal_parathyroid_gland | 1.58320144 |
27 | MP0000627_abnormal_mammary_gland | 1.54580507 |
28 | MP0001216_abnormal_epidermal_layer | 1.52924468 |
29 | MP0001765_abnormal_ion_homeostasis | 1.47169010 |
30 | MP0005310_abnormal_salivary_gland | 1.45021032 |
31 | MP0000377_abnormal_hair_follicle | 1.43864395 |
32 | MP0004043_abnormal_pH_regulation | 1.42677958 |
33 | MP0001346_abnormal_lacrimal_gland | 1.29870913 |
34 | MP0004381_abnormal_hair_follicle | 1.24602346 |
35 | MP0004782_abnormal_surfactant_physiolog | 1.23833368 |
36 | MP0005666_abnormal_adipose_tissue | 1.23302275 |
37 | MP0009840_abnormal_foam_cell | 1.22539441 |
38 | MP0001666_abnormal_nutrient_absorption | 1.19938701 |
39 | MP0000467_abnormal_esophagus_morphology | 1.19663031 |
40 | MP0004185_abnormal_adipocyte_glucose | 1.19035633 |
41 | MP0002060_abnormal_skin_morphology | 1.17949445 |
42 | MP0003436_decreased_susceptibility_to | 1.16860218 |
43 | MP0005360_urolithiasis | 1.15202395 |
44 | MP0009643_abnormal_urine_homeostasis | 1.14670152 |
45 | MP0003566_abnormal_cell_adhesion | 1.11788658 |
46 | MP0005409_darkened_coat_color | 1.11621988 |
47 | MP0005248_abnormal_Harderian_gland | 1.11481424 |
48 | MP0001664_abnormal_digestion | 1.10668301 |
49 | MP0001533_abnormal_skeleton_physiology | 1.10222785 |
50 | MP0005647_abnormal_sex_gland | 1.08915060 |
51 | MP0005636_abnormal_mineral_homeostasis | 1.05047001 |
52 | MP0003638_abnormal_response/metabolism_ | 1.04778533 |
53 | MP0009931_abnormal_skin_appearance | 1.03146630 |
54 | MP0000858_altered_metastatic_potential | 1.01745602 |
55 | MP0000383_abnormal_hair_follicle | 1.01668444 |
56 | MP0000681_abnormal_thyroid_gland | 1.01318656 |
57 | MP0005076_abnormal_cell_differentiation | 1.01310000 |
58 | MP0005365_abnormal_bile_salt | 0.98969494 |
59 | MP0010771_integument_phenotype | 0.97847887 |
60 | MP0001756_abnormal_urination | 0.97341191 |
61 | MP0002896_abnormal_bone_mineralization | 0.93204747 |
62 | MP0000465_gastrointestinal_hemorrhage | 0.92787039 |
63 | MP0003866_abnormal_defecation | 0.91565920 |
64 | MP0000367_abnormal_coat/_hair | 0.90119396 |
65 | MP0003045_fibrosis | 0.90089094 |
66 | MP0003075_altered_response_to | 0.89566848 |
67 | MP0005165_increased_susceptibility_to | 0.89206771 |
68 | MP0005025_abnormal_response_to | 0.85849342 |
69 | MP0008875_abnormal_xenobiotic_pharmacok | 0.84236602 |
70 | MP0002933_joint_inflammation | 0.84194999 |
71 | MP0000613_abnormal_salivary_gland | 0.83815978 |
72 | MP0000538_abnormal_urinary_bladder | 0.83491360 |
73 | MP0005503_abnormal_tendon_morphology | 0.83402230 |
74 | MP0005166_decreased_susceptibility_to | 0.82507154 |
75 | MP0001849_ear_inflammation | 0.82034364 |
76 | MP0008260_abnormal_autophagy | 0.81808577 |
77 | MP0002148_abnormal_hypersensitivity_rea | 0.81499982 |
78 | MP0004019_abnormal_vitamin_homeostasis | 0.79977292 |
79 | MP0001919_abnormal_reproductive_system | 0.78373662 |
80 | MP0000470_abnormal_stomach_morphology | 0.78351589 |
81 | MP0001851_eye_inflammation | 0.76488586 |
82 | MP0001845_abnormal_inflammatory_respons | 0.76131558 |
83 | MP0003303_peritoneal_inflammation | 0.76008211 |
84 | MP0000427_abnormal_hair_cycle | 0.75064267 |
85 | MP0005408_hypopigmentation | 0.73275215 |
86 | MP0002108_abnormal_muscle_morphology | 0.73083015 |
87 | MP0000477_abnormal_intestine_morphology | 0.72520374 |
88 | MP0002277_abnormal_respiratory_mucosa | 0.71702933 |
89 | MP0002254_reproductive_system_inflammat | 0.71077045 |
90 | MP0005375_adipose_tissue_phenotype | 0.70402452 |
91 | MP0001243_abnormal_dermal_layer | 0.70150299 |
92 | MP0002136_abnormal_kidney_physiology | 0.69657740 |
93 | MP0000609_abnormal_liver_physiology | 0.67436381 |
94 | MP0003315_abnormal_perineum_morphology | 0.66687361 |
95 | MP0003123_paternal_imprinting | 0.65905979 |
96 | MP0001727_abnormal_embryo_implantation | 0.65427859 |
97 | MP0005646_abnormal_pituitary_gland | 0.65233181 |
98 | MP0002249_abnormal_larynx_morphology | 0.64401260 |
99 | MP0000462_abnormal_digestive_system | 0.64233910 |
100 | MP0003936_abnormal_reproductive_system | 0.64115013 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Right ventricular cardiomyopathy (HP:0011663) | 3.99696658 |
2 | Flat acetabular roof (HP:0003180) | 3.77865800 |
3 | Hyperactive renin-angiotensin system (HP:0000841) | 3.55545185 |
4 | Chronic bronchitis (HP:0004469) | 3.45764013 |
5 | Distal lower limb muscle weakness (HP:0009053) | 3.41052175 |
6 | Increased IgE level (HP:0003212) | 3.29303625 |
7 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 3.28108854 |
8 | Pili torti (HP:0003777) | 3.28045121 |
9 | Sparse lateral eyebrow (HP:0005338) | 3.21034778 |
10 | Thin bony cortex (HP:0002753) | 3.19307898 |
11 | Nasal polyposis (HP:0100582) | 3.13020264 |
12 | Systemic lupus erythematosus (HP:0002725) | 2.99564354 |
13 | Abnormality of the nasal mucosa (HP:0000433) | 2.98051576 |
14 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.77510367 |
15 | Glomerulonephritis (HP:0000099) | 2.77286381 |
16 | Acanthosis nigricans (HP:0000956) | 2.75213584 |
17 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.63867760 |
18 | Bulbar palsy (HP:0001283) | 2.58837478 |
19 | Esophageal varix (HP:0002040) | 2.58346451 |
20 | Deep venous thrombosis (HP:0002625) | 2.54278451 |
21 | Lip pit (HP:0100267) | 2.48074215 |
22 | Germ cell neoplasia (HP:0100728) | 2.46972531 |
23 | Complement deficiency (HP:0004431) | 2.44489710 |
24 | Amelogenesis imperfecta (HP:0000705) | 2.42212718 |
25 | Asymmetry of the thorax (HP:0001555) | 2.41090465 |
26 | Dysostosis multiplex (HP:0000943) | 2.38293800 |
27 | Abnormal hair laboratory examination (HP:0003328) | 2.36241724 |
28 | Rhinitis (HP:0012384) | 2.35654316 |
29 | Abnormality of nail color (HP:0100643) | 2.35075236 |
30 | Ulnar claw (HP:0001178) | 2.32644401 |
31 | Abnormality of small intestinal villus morphology (HP:0011472) | 2.32374175 |
32 | Villous atrophy (HP:0011473) | 2.32374175 |
33 | Oligomenorrhea (HP:0000876) | 2.32050117 |
34 | Abnormality of complement system (HP:0005339) | 2.30673322 |
35 | Growth hormone excess (HP:0000845) | 2.29308734 |
36 | Abnormal tarsal ossification (HP:0008369) | 2.27974630 |
37 | Nephritis (HP:0000123) | 2.26709723 |
38 | J-shaped sella turcica (HP:0002680) | 2.26590333 |
39 | Bronchitis (HP:0012387) | 2.25605698 |
40 | Mucopolysacchariduria (HP:0008155) | 2.25306339 |
41 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.25306339 |
42 | Hyperkalemia (HP:0002153) | 2.22526365 |
43 | Malnutrition (HP:0004395) | 2.18998847 |
44 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 2.18565384 |
45 | Cervical subluxation (HP:0003308) | 2.18337431 |
46 | Hyperparathyroidism (HP:0000843) | 2.17890476 |
47 | Decreased circulating renin level (HP:0003351) | 2.17887360 |
48 | Hemorrhage of the eye (HP:0011885) | 2.17565069 |
49 | Testicular neoplasm (HP:0010788) | 2.17125787 |
50 | Concave nail (HP:0001598) | 2.16412739 |
51 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.14440096 |
52 | Myopathic facies (HP:0002058) | 2.12689167 |
53 | Hypotrichosis (HP:0001006) | 2.11759894 |
54 | Diaphragmatic weakness (HP:0009113) | 2.07907416 |
55 | Renal salt wasting (HP:0000127) | 2.05330405 |
56 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.04843192 |
57 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.04843192 |
58 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.04843192 |
59 | Spinal cord compression (HP:0002176) | 2.04492912 |
60 | Vertebral compression fractures (HP:0002953) | 2.04299698 |
61 | Bronchiectasis (HP:0002110) | 2.04242289 |
62 | Erythema (HP:0010783) | 1.99946863 |
63 | Woolly hair (HP:0002224) | 1.99570922 |
64 | Seborrheic dermatitis (HP:0001051) | 1.99413252 |
65 | Septate vagina (HP:0001153) | 1.98594785 |
66 | Increased cerebral lipofuscin (HP:0011813) | 1.98253090 |
67 | Abnormality of carpal bone ossification (HP:0006257) | 1.97304861 |
68 | Loss of speech (HP:0002371) | 1.97266536 |
69 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.97106551 |
70 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.96974659 |
71 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.96974659 |
72 | Visceral angiomatosis (HP:0100761) | 1.95686595 |
73 | Pigmentary retinal degeneration (HP:0001146) | 1.94746545 |
74 | Lymphangioma (HP:0100764) | 1.92800722 |
75 | Testicular atrophy (HP:0000029) | 1.90639565 |
76 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.89927352 |
77 | Hyporeflexia of lower limbs (HP:0002600) | 1.89234096 |
78 | Axonal loss (HP:0003447) | 1.88231885 |
79 | Hyperammonemia (HP:0001987) | 1.85919930 |
80 | Flattened epiphyses (HP:0003071) | 1.85630725 |
81 | Abdominal distention (HP:0003270) | 1.85430011 |
82 | Infertility (HP:0000789) | 1.84920727 |
83 | Colitis (HP:0002583) | 1.84409927 |
84 | Alopecia of scalp (HP:0002293) | 1.83280612 |
85 | Segmental peripheral demyelination/remyelination (HP:0003481) | 1.81705890 |
86 | Cone-rod dystrophy (HP:0000548) | 1.81114061 |
87 | Neoplasm of the heart (HP:0100544) | 1.79509848 |
88 | Vacuolated lymphocytes (HP:0001922) | 1.78648974 |
89 | Intrahepatic cholestasis (HP:0001406) | 1.77213831 |
90 | Dehydration (HP:0001944) | 1.77153337 |
91 | Stroke (HP:0001297) | 1.77060308 |
92 | Hemangiomatosis (HP:0007461) | 1.74752490 |
93 | Advanced eruption of teeth (HP:0006288) | 1.74044029 |
94 | Eczematoid dermatitis (HP:0000976) | 1.72923786 |
95 | Congenital glaucoma (HP:0001087) | 1.71616801 |
96 | Interstitial pulmonary disease (HP:0006530) | 1.70804485 |
97 | Short nail (HP:0001799) | 1.68831898 |
98 | Bone pain (HP:0002653) | 1.68543616 |
99 | Insidious onset (HP:0003587) | 1.68303014 |
100 | Termporal pattern (HP:0011008) | 1.68303014 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TRIB3 | 5.94119523 |
2 | EPHA2 | 5.30608590 |
3 | MAPKAPK3 | 3.57250911 |
4 | PKN2 | 3.36260460 |
5 | ERN1 | 2.88862330 |
6 | TESK1 | 2.86685288 |
7 | EEF2K | 2.81091192 |
8 | SIK1 | 2.52662359 |
9 | RPS6KB2 | 2.27608730 |
10 | MST1R | 2.23144057 |
11 | MAP3K3 | 2.05186871 |
12 | SMG1 | 1.92164235 |
13 | MAPK15 | 1.87923728 |
14 | RIPK1 | 1.81709560 |
15 | NME2 | 1.80532572 |
16 | MUSK | 1.74069427 |
17 | SCYL2 | 1.67827035 |
18 | FER | 1.61378827 |
19 | PTK6 | 1.54663603 |
20 | PIK3CA | 1.51495596 |
21 | TBK1 | 1.50922662 |
22 | LRRK2 | 1.49876075 |
23 | TESK2 | 1.44926419 |
24 | ICK | 1.28375879 |
25 | NEK6 | 1.25786637 |
26 | IRAK3 | 1.23299368 |
27 | FGFR4 | 1.23228007 |
28 | ILK | 1.22731463 |
29 | MAP2K2 | 1.22645204 |
30 | PAK4 | 1.21850577 |
31 | PIM2 | 1.05555814 |
32 | TNK2 | 1.01664626 |
33 | AKT3 | 0.99967466 |
34 | MAP2K3 | 0.98733205 |
35 | STK39 | 0.97628040 |
36 | TAOK1 | 0.97318995 |
37 | MST4 | 0.97083779 |
38 | PRKD3 | 0.96344797 |
39 | MAP3K12 | 0.93874933 |
40 | PRKCI | 0.92513035 |
41 | GRK6 | 0.91058725 |
42 | HIPK2 | 0.84289274 |
43 | PDPK1 | 0.83917642 |
44 | RPS6KA2 | 0.82814748 |
45 | LMTK2 | 0.82645437 |
46 | EPHB1 | 0.82331167 |
47 | MYLK | 0.81833546 |
48 | BCKDK | 0.81312944 |
49 | ARAF | 0.80007329 |
50 | EPHA3 | 0.78137824 |
51 | BMPR2 | 0.77904610 |
52 | IKBKE | 0.76604892 |
53 | CHUK | 0.75731247 |
54 | RET | 0.70487382 |
55 | MAP3K11 | 0.69498843 |
56 | DMPK | 0.67620808 |
57 | MAP3K1 | 0.67381526 |
58 | MAPKAPK2 | 0.67162579 |
59 | OBSCN | 0.66392486 |
60 | TRPM7 | 0.63603180 |
61 | IKBKB | 0.62749493 |
62 | BLK | 0.61727773 |
63 | MTOR | 0.61557461 |
64 | PRKD2 | 0.58744727 |
65 | TAOK2 | 0.58073830 |
66 | CDK7 | 0.56021778 |
67 | PRKD1 | 0.54909381 |
68 | MET | 0.54286035 |
69 | MAP2K1 | 0.53365736 |
70 | RPS6KC1 | 0.51655779 |
71 | RPS6KL1 | 0.51655779 |
72 | CAMK1D | 0.46722959 |
73 | MAP3K14 | 0.45064830 |
74 | ZAP70 | 0.43062380 |
75 | STK24 | 0.42539269 |
76 | PRPF4B | 0.42309945 |
77 | MATK | 0.41162600 |
78 | LIMK1 | 0.40927460 |
79 | PTK2 | 0.40719492 |
80 | VRK2 | 0.40323192 |
81 | MAP3K2 | 0.37948214 |
82 | RPS6KA6 | 0.37771709 |
83 | MAP2K6 | 0.37640689 |
84 | PDK1 | 0.36971719 |
85 | RIPK4 | 0.34615740 |
86 | PRKAA2 | 0.34410832 |
87 | MAP4K1 | 0.33482225 |
88 | JAK1 | 0.31446751 |
89 | PRKG2 | 0.31385641 |
90 | DDR2 | 0.30806439 |
91 | JAK2 | 0.30735934 |
92 | MAP3K6 | 0.30023061 |
93 | CAMK2G | 0.29527646 |
94 | CDC42BPA | 0.29221810 |
95 | STK38 | 0.28632125 |
96 | CSK | 0.28355043 |
97 | CDK9 | 0.28059121 |
98 | EPHB2 | 0.27652021 |
99 | TYK2 | 0.27459499 |
100 | DYRK1B | 0.27109004 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 3.33033586 |
2 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 2.76926937 |
3 | Other glycan degradation_Homo sapiens_hsa00511 | 2.45518532 |
4 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 2.24833363 |
5 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 2.18816487 |
6 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.18590039 |
7 | Salivary secretion_Homo sapiens_hsa04970 | 2.05812676 |
8 | Histidine metabolism_Homo sapiens_hsa00340 | 2.00033937 |
9 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.77498116 |
10 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.73545610 |
11 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.64378933 |
12 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.61034179 |
13 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.56565963 |
14 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.54314685 |
15 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.53391056 |
16 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.51174621 |
17 | Lysosome_Homo sapiens_hsa04142 | 1.49081143 |
18 | Renin-angiotensin system_Homo sapiens_hsa04614 | 1.46036159 |
19 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.42867206 |
20 | Hepatitis C_Homo sapiens_hsa05160 | 1.41318485 |
21 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.41139430 |
22 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.40067565 |
23 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.36026305 |
24 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.34466413 |
25 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.33256402 |
26 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.26203316 |
27 | Galactose metabolism_Homo sapiens_hsa00052 | 1.23604033 |
28 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.17962093 |
29 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.14708738 |
30 | Asthma_Homo sapiens_hsa05310 | 1.13773805 |
31 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.13226590 |
32 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.05901120 |
33 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.05007959 |
34 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.04123483 |
35 | Mineral absorption_Homo sapiens_hsa04978 | 1.02977354 |
36 | Insulin resistance_Homo sapiens_hsa04931 | 1.01547328 |
37 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.00525453 |
38 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.97932282 |
39 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.96096593 |
40 | Sulfur relay system_Homo sapiens_hsa04122 | 0.92751877 |
41 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.90440374 |
42 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.90133305 |
43 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.88544907 |
44 | Influenza A_Homo sapiens_hsa05164 | 0.87704302 |
45 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.86243609 |
46 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.85297658 |
47 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.84061998 |
48 | Prostate cancer_Homo sapiens_hsa05215 | 0.83594618 |
49 | Endometrial cancer_Homo sapiens_hsa05213 | 0.82540756 |
50 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.81919833 |
51 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.80705423 |
52 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.80408445 |
53 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.79121175 |
54 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.77179325 |
55 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.76061938 |
56 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.75578616 |
57 | Thyroid cancer_Homo sapiens_hsa05216 | 0.75559083 |
58 | Amoebiasis_Homo sapiens_hsa05146 | 0.75502086 |
59 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.74202603 |
60 | Legionellosis_Homo sapiens_hsa05134 | 0.73435642 |
61 | Tight junction_Homo sapiens_hsa04530 | 0.70539314 |
62 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.70519390 |
63 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.69786352 |
64 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.69641116 |
65 | Leishmaniasis_Homo sapiens_hsa05140 | 0.69565216 |
66 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.69525122 |
67 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.69313707 |
68 | Allograft rejection_Homo sapiens_hsa05330 | 0.67789521 |
69 | ABC transporters_Homo sapiens_hsa02010 | 0.67724838 |
70 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.66077960 |
71 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.65863225 |
72 | Peroxisome_Homo sapiens_hsa04146 | 0.65651461 |
73 | Pertussis_Homo sapiens_hsa05133 | 0.63827442 |
74 | Bladder cancer_Homo sapiens_hsa05219 | 0.62812091 |
75 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.62475602 |
76 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.62256280 |
77 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.61536999 |
78 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.61473564 |
79 | Endocytosis_Homo sapiens_hsa04144 | 0.61227148 |
80 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.60952392 |
81 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.60923129 |
82 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.59874166 |
83 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.58491334 |
84 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.57231635 |
85 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.56993859 |
86 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.56323477 |
87 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.55695710 |
88 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.55321405 |
89 | Prion diseases_Homo sapiens_hsa05020 | 0.54098006 |
90 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.53667576 |
91 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.53633272 |
92 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.53196300 |
93 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.52449256 |
94 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.50011259 |
95 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.49655202 |
96 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.48964734 |
97 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.48763840 |
98 | Tuberculosis_Homo sapiens_hsa05152 | 0.48700375 |
99 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.47947871 |
100 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.47513767 |