ZGLP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)7.06477140
2positive regulation of protein homodimerization activity (GO:0090073)6.96239667
3neutrophil activation involved in immune response (GO:0002283)6.58210729
4piRNA metabolic process (GO:0034587)6.05838880
5negative regulation of heart rate (GO:0010459)5.98627812
6thrombin receptor signaling pathway (GO:0070493)5.60429344
7neuronal action potential propagation (GO:0019227)5.25365579
8DNA methylation involved in gamete generation (GO:0043046)5.18373269
9adenosine receptor signaling pathway (GO:0001973)5.13347730
10regulation of protein heterodimerization activity (GO:0043497)5.07255437
11nuclear pore organization (GO:0006999)4.94443378
12mitotic metaphase plate congression (GO:0007080)4.90460114
13synaptonemal complex assembly (GO:0007130)4.76274238
14regulation of platelet activation (GO:0010543)4.61950153
15meiotic chromosome segregation (GO:0045132)4.56234052
16positive regulation of mast cell activation (GO:0033005)4.50468604
17nuclear pore complex assembly (GO:0051292)4.48921365
18regulation of platelet aggregation (GO:0090330)4.43088619
19kinetochore organization (GO:0051383)4.37877912
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.32746585
21positive regulation of cAMP-mediated signaling (GO:0043950)4.29430490
22Arp2/3 complex-mediated actin nucleation (GO:0034314)4.29152776
23protein localization to kinetochore (GO:0034501)4.29092913
24mitotic nuclear envelope disassembly (GO:0007077)4.28560127
25DNA strand elongation involved in DNA replication (GO:0006271)4.23492080
26DNA replication initiation (GO:0006270)4.23398661
27chromatin remodeling at centromere (GO:0031055)4.23393944
28ribosome biogenesis (GO:0042254)4.22600070
29attachment of spindle microtubules to kinetochore (GO:0008608)4.21996254
30metaphase plate congression (GO:0051310)4.21479603
31synaptonemal complex organization (GO:0070193)4.19476046
32leukocyte migration involved in inflammatory response (GO:0002523)4.18309115
33DNA replication checkpoint (GO:0000076)4.17993092
34DNA unwinding involved in DNA replication (GO:0006268)4.17986364
35cerebellar granule cell differentiation (GO:0021707)4.17544416
36kinetochore assembly (GO:0051382)4.16793347
37DNA replication-dependent nucleosome organization (GO:0034723)4.10875107
38DNA replication-dependent nucleosome assembly (GO:0006335)4.10875107
39telomere maintenance via semi-conservative replication (GO:0032201)4.10747617
40formation of translation preinitiation complex (GO:0001731)4.07266051
41mitotic sister chromatid segregation (GO:0000070)4.00437293
42nuclear envelope disassembly (GO:0051081)3.99984785
43membrane disassembly (GO:0030397)3.99984785
44maturation of SSU-rRNA (GO:0030490)3.97490686
45DNA strand elongation (GO:0022616)3.96164351
46CENP-A containing nucleosome assembly (GO:0034080)3.94691008
47neutrophil activation (GO:0042119)3.92297834
48polyamine biosynthetic process (GO:0006596)3.89690079
49nucleobase biosynthetic process (GO:0046112)3.88086100
50lipoxygenase pathway (GO:0019372)3.86523703
51negative regulation of appetite (GO:0032099)3.82295647
52negative regulation of response to food (GO:0032096)3.82295647
53blood coagulation, intrinsic pathway (GO:0007597)3.81779733
54protein localization to chromosome, centromeric region (GO:0071459)3.78612707
55meiotic nuclear division (GO:0007126)3.75370138
56regulation of gene silencing by RNA (GO:0060966)3.75261626
57regulation of posttranscriptional gene silencing (GO:0060147)3.75261626
58regulation of gene silencing by miRNA (GO:0060964)3.75261626
59positive regulation of systemic arterial blood pressure (GO:0003084)3.73304794
60mitotic chromosome condensation (GO:0007076)3.71954465
61establishment of chromosome localization (GO:0051303)3.71470987
62negative regulation of platelet activation (GO:0010544)3.69871967
63telomere maintenance via recombination (GO:0000722)3.69509190
64DNA replication-independent nucleosome assembly (GO:0006336)3.66990993
65DNA replication-independent nucleosome organization (GO:0034724)3.66990993
66granulocyte activation (GO:0036230)3.66862972
67negative regulation of calcium ion transport into cytosol (GO:0010523)3.66444143
68IMP biosynthetic process (GO:0006188)3.66023755
69fusion of sperm to egg plasma membrane (GO:0007342)3.65090973
70platelet aggregation (GO:0070527)3.64933274
71negative regulation of norepinephrine secretion (GO:0010700)3.64789161
72positive regulation of mast cell degranulation (GO:0043306)3.63280268
73positive regulation of mast cell activation involved in immune response (GO:0033008)3.63280268
74heterochromatin organization (GO:0070828)3.62721009
75chromosome organization involved in meiosis (GO:0070192)3.61758241
76mitotic recombination (GO:0006312)3.60557363
77negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.60502290
78DNA synthesis involved in DNA repair (GO:0000731)3.60474611
79regulation of translational termination (GO:0006449)3.59091761
80sister chromatid segregation (GO:0000819)3.58829515
81low-density lipoprotein particle remodeling (GO:0034374)3.58485358
82histone exchange (GO:0043486)3.56139141
83purine nucleobase biosynthetic process (GO:0009113)3.55620708
84actin nucleation (GO:0045010)3.54528072
85telomere maintenance via telomere lengthening (GO:0010833)3.53848078
86regulation of meiosis I (GO:0060631)3.51815235
87protein K6-linked ubiquitination (GO:0085020)3.51367803
88regulation of integrin-mediated signaling pathway (GO:2001044)3.50229149
89purinergic nucleotide receptor signaling pathway (GO:0035590)3.49567591
90ribonucleoprotein complex biogenesis (GO:0022613)3.48626512
91calcium-mediated signaling using intracellular calcium source (GO:0035584)3.47649167
92DNA methylation (GO:0006306)3.44882368
93DNA alkylation (GO:0006305)3.44882368
94folic acid-containing compound biosynthetic process (GO:0009396)3.41326388
95male meiosis (GO:0007140)3.41187944
96pore complex assembly (GO:0046931)3.38398926
97negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.37783024
98regulation of double-strand break repair via homologous recombination (GO:0010569)3.37379202
99reciprocal DNA recombination (GO:0035825)3.37078970
100reciprocal meiotic recombination (GO:0007131)3.37078970
101regulation of mast cell activation (GO:0033003)3.34113333
102resolution of meiotic recombination intermediates (GO:0000712)3.33613369
103G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.32338791
104regulation of mitotic spindle checkpoint (GO:1903504)3.32334780
105regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32334780
106regulation of spindle organization (GO:0090224)3.30618660
107spindle checkpoint (GO:0031577)3.30033451
108meiotic cell cycle process (GO:1903046)3.29951879
109somatic hypermutation of immunoglobulin genes (GO:0016446)3.29444536
110somatic diversification of immune receptors via somatic mutation (GO:0002566)3.29444536
111negative regulation of cation channel activity (GO:2001258)3.27934668
112gene silencing by RNA (GO:0031047)3.27689324
113protein maturation by protein folding (GO:0022417)3.27524931
114maturation of 5.8S rRNA (GO:0000460)3.27380541
115regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27033512
116nucleotide-excision repair, DNA gap filling (GO:0006297)3.23973142
117regulation of mast cell degranulation (GO:0043304)3.19600038
118ribosome assembly (GO:0042255)3.19598744
119IMP metabolic process (GO:0046040)3.18555561
120regulation of centrosome cycle (GO:0046605)3.17686265
121purinergic receptor signaling pathway (GO:0035587)3.17001106
122regulation of sensory perception of pain (GO:0051930)3.16724795
123regulation of sensory perception (GO:0051931)3.16724795
124peptidyl-arginine omega-N-methylation (GO:0035247)3.16114880
125mitotic spindle checkpoint (GO:0071174)3.15947092
126regulation of nuclear cell cycle DNA replication (GO:0033262)3.15936343
127folic acid metabolic process (GO:0046655)3.15890634
128negative regulation of chromosome segregation (GO:0051985)3.15789148
129negative regulation of homotypic cell-cell adhesion (GO:0034111)3.14476386
130regulation of norepinephrine secretion (GO:0014061)3.13949798
131ribosomal large subunit biogenesis (GO:0042273)3.13087406
132neuron remodeling (GO:0016322)3.12867813
133chromatin assembly or disassembly (GO:0006333)3.12694398
134negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.12326366
135regulation of chromosome segregation (GO:0051983)3.12081153
136chromosome segregation (GO:0007059)3.11984652
137negative regulation of heart contraction (GO:0045822)3.09735724
138negative regulation of mitotic sister chromatid separation (GO:2000816)3.09147424
139negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09147424
140negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09147424
141negative regulation of sister chromatid segregation (GO:0033046)3.09147424
142regulation of mitotic spindle organization (GO:0060236)3.08571155
143mitotic spindle assembly checkpoint (GO:0007094)3.08247261
144regulation of mast cell activation involved in immune response (GO:0033006)3.08088627
145negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07920746
146sequestering of actin monomers (GO:0042989)3.07347880
147rRNA processing (GO:0006364)3.07282661
148spindle assembly checkpoint (GO:0071173)3.05497765
149mRNA export from nucleus (GO:0006406)3.05358006
150regulation of centriole replication (GO:0046599)3.04983608
151RNA export from nucleus (GO:0006405)3.04854388
152negative regulation of meiosis (GO:0045835)3.04654910
153glycerophospholipid catabolic process (GO:0046475)3.04099772
154regulation of neuron projection regeneration (GO:0070570)3.03118621
155regulation of axon regeneration (GO:0048679)3.03118621
156leukocyte degranulation (GO:0043299)2.99778207
157regulation of cAMP-mediated signaling (GO:0043949)2.98509929
158negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.96823855
159negative regulation of calcium ion transmembrane transport (GO:1903170)2.96823855
160regulation of cholesterol efflux (GO:0010874)2.90163426
161G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.89949864
162regulation of MHC class II biosynthetic process (GO:0045346)2.89768681
163regulation of thymocyte apoptotic process (GO:0070243)2.89645085
164regulation of catecholamine metabolic process (GO:0042069)2.89151975
165regulation of dopamine metabolic process (GO:0042053)2.89151975
166cellular biogenic amine biosynthetic process (GO:0042401)2.85926441
167protein insertion into membrane (GO:0051205)2.84641562
168negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.83973745
169negative regulation of thymocyte apoptotic process (GO:0070244)2.83121224
170regulation of protein homodimerization activity (GO:0043496)2.82571720
171platelet formation (GO:0030220)2.81124666
172negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.79019608
173superoxide anion generation (GO:0042554)2.77989249
174amine biosynthetic process (GO:0009309)2.77426479
175regulation of female receptivity (GO:0045924)2.76428791
176regulation of glycogen (starch) synthase activity (GO:2000465)2.72996579
177lysosome localization (GO:0032418)2.70316106
178G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.69399921
179positive regulation of T cell apoptotic process (GO:0070234)2.68879708
180female mating behavior (GO:0060180)2.68446681
181polyamine metabolic process (GO:0006595)2.64118705
182regulation of integrin activation (GO:0033623)2.63730404
183regulation of mitochondrial depolarization (GO:0051900)2.62615248
184positive regulation of protein kinase C signaling (GO:0090037)2.62196126
185myeloid cell activation involved in immune response (GO:0002275)2.60921425
186platelet activation (GO:0030168)2.60505716
187plasma membrane fusion (GO:0045026)2.60414888
188megakaryocyte development (GO:0035855)2.59223145
189negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.58713781
190membrane invagination (GO:0010324)2.57074299
191platelet degranulation (GO:0002576)2.55578786
192detection of temperature stimulus involved in sensory perception (GO:0050961)2.55467293
193detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.55467293
194positive regulation of neurotransmitter secretion (GO:0001956)2.54567851
195negative regulation of mast cell activation (GO:0033004)2.54090813
196angiogenesis involved in wound healing (GO:0060055)2.53378973
197vesicle targeting (GO:0006903)2.52974233
198regulation of homotypic cell-cell adhesion (GO:0034110)2.51970334
199negative regulation of catecholamine secretion (GO:0033604)2.51078669
200homotypic cell-cell adhesion (GO:0034109)2.49896517

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human9.41307215
2E2F7_22180533_ChIP-Seq_HELA_Human9.19428830
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.62184930
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.30938719
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.85647743
6* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.59136396
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.37385909
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34721687
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.28486905
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.26195885
11IKZF1_21737484_ChIP-ChIP_HCT116_Human3.24247008
12MYC_19030024_ChIP-ChIP_MESCs_Mouse3.01826224
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.94802730
14SCL_19346495_ChIP-Seq_HPC-7_Human2.92071806
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.88788869
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.76744215
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.76660430
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75355838
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.70146376
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.69759425
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.60164525
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58086948
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.57120150
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.55448309
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.49115762
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45501542
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44939146
28SRY_22984422_ChIP-ChIP_TESTIS_Rat2.41406528
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39406388
30STAT6_21828071_ChIP-Seq_BEAS2B_Human2.36463637
31AR_21909140_ChIP-Seq_LNCAP_Human2.29824011
32XRN2_22483619_ChIP-Seq_HELA_Human2.29547010
33MYCN_18555785_ChIP-Seq_MESCs_Mouse2.27397914
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.22960908
35GABP_17652178_ChIP-ChIP_JURKAT_Human2.22602317
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.19478629
37GATA1_19941827_ChIP-Seq_MEL_Mouse2.18102315
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15293807
39E2F1_21310950_ChIP-Seq_MCF-7_Human2.14964132
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14634918
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.14106000
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13606584
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02400646
44VDR_23849224_ChIP-Seq_CD4+_Human1.98421489
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97611168
46SPI1_23127762_ChIP-Seq_K562_Human1.94874539
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93577686
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89528844
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88422620
50* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.88355464
51ELK4_26923725_Chip-Seq_MESODERM_Mouse1.87464864
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86484624
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.82224630
54DCP1A_22483619_ChIP-Seq_HELA_Human1.81701121
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79156352
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74919220
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71597354
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70755435
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.69960476
60IRF1_19129219_ChIP-ChIP_H3396_Human1.67891475
61GATA1_19941826_ChIP-Seq_K562_Human1.67730704
62MYC_22102868_ChIP-Seq_BL_Human1.65896766
63FOXP3_21729870_ChIP-Seq_TREG_Human1.65178830
64GABP_19822575_ChIP-Seq_HepG2_Human1.64384059
65TTF2_22483619_ChIP-Seq_HELA_Human1.63675027
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.62679243
67KDM5A_27292631_Chip-Seq_BREAST_Human1.62529156
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62271180
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58235045
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.57195276
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.57195276
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.57195276
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56907489
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.53918510
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.52506654
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.51271116
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50491120
78IRF8_27001747_Chip-Seq_BMDM_Mouse1.50488634
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.49772876
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49302472
81CIITA_25753668_ChIP-Seq_RAJI_Human1.47113505
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44848091
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.43180465
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42192059
85BCL6_27268052_Chip-Seq_Bcells_Human1.41137544
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38431288
87P68_20966046_ChIP-Seq_HELA_Human1.38304247
88HTT_18923047_ChIP-ChIP_STHdh_Human1.37537445
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.35913104
90BCOR_27268052_Chip-Seq_Bcells_Human1.35287377
91GATA2_19941826_ChIP-Seq_K562_Human1.35201528
92REST_18959480_ChIP-ChIP_MESCs_Mouse1.35066411
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34700697
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34155168
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32997983
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32326150
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31529709
98YY1_22570637_ChIP-Seq_MALME-3M_Human1.28651362
99ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28010541
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27152770
101ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23802662
102ELK1_19687146_ChIP-ChIP_HELA_Human1.22601511
103SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22489914
104TFEB_21752829_ChIP-Seq_HELA_Human1.21460960
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20548496
106REST_21632747_ChIP-Seq_MESCs_Mouse1.19912929
107E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19725610
108NOTCH1_21737748_ChIP-Seq_TLL_Human1.19137669
109CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17589324
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16673410
111TP63_19390658_ChIP-ChIP_HaCaT_Human1.14345118
112ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14243748
113SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13487486
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13406134
115UTX_26944678_Chip-Seq_JUKART_Human1.11705959
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11699720
117SPI1_20517297_ChIP-Seq_HL60_Human1.10926301
118E2F1_20622854_ChIP-Seq_HELA_Human1.10226220
119SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10063436
120NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.09705452
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08953714
122ELF1_20517297_ChIP-Seq_JURKAT_Human1.08548462
123TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07844505
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07392211
125LXR_22292898_ChIP-Seq_THP-1_Human1.06643270
126CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06297984
127HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05650145
128SOX2_21211035_ChIP-Seq_LN229_Human1.05364210
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04988996
130Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04024039
131THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03704891
132IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02758615
133FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02710320
134MYC_18940864_ChIP-ChIP_HL60_Human1.02622443
135NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.01891743
136CTCF_20526341_ChIP-Seq_ESCs_Human1.01828686
137PHF8_20622854_ChIP-Seq_HELA_Human1.01641424
138TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01402574
139EZH2_27294783_Chip-Seq_ESCs_Mouse1.01389179
140CTCF_26484167_Chip-Seq_Bcells_Mouse1.01264905
141EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01159436
142KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00789690
143CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00591503
144CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99476540
145TET1_21451524_ChIP-Seq_MESCs_Mouse0.99096452
146SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99045111
147CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98630197
148FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98193632
149TAF2_19829295_ChIP-Seq_ESCs_Human0.97729630
150SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96891208
151RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96270586
152SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95536170
153GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95338433
154ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95201868
155STAT1_20625510_ChIP-Seq_HELA_Human0.94890147
156SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94684882
157SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.93063867
158EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92926800
159EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92779522
160KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92714616
161CTCF_21964334_Chip-Seq_Bcells_Human0.92306134
162* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91919490
163OCT4_20526341_ChIP-Seq_ESCs_Human0.91599274
164RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91432478
165TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91214448
166SRF_21415370_ChIP-Seq_HL-1_Mouse0.91167602
167CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91128622
168DROSHA_22980978_ChIP-Seq_HELA_Human0.90663874
169KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90544084
170SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90151743
171ERA_21632823_ChIP-Seq_H3396_Human0.90042241
172CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89879701
173P300_27268052_Chip-Seq_Bcells_Human0.89031157
174GBX2_23144817_ChIP-Seq_PC3_Human0.88735068
175PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88396091
176PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86564032
177TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.86404761
178CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85838309
179EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85485959
180SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85334336
181GATA2_21666600_ChIP-Seq_HMVEC_Human0.84974135
182CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84964090
183RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84528060
184GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83719451
185BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83049380
186NANOG_21062744_ChIP-ChIP_HESCs_Human0.82999739
187PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82661194
188KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.81108566
189OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81102081
190OCT4_19829295_ChIP-Seq_ESCs_Human0.80608970
191BCAT_22108803_ChIP-Seq_LS180_Human0.80298919
192NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80069592
193SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79476133
194SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.79047682
195POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.78447241
196VDR_22108803_ChIP-Seq_LS180_Human0.78261340
197STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77895354
198PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.77135877
199POU5F1_16518401_ChIP-PET_MESCs_Mouse0.75478888

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology7.02264972
2MP0003693_abnormal_embryo_hatching5.68068798
3MP0008877_abnormal_DNA_methylation5.42133430
4MP0010094_abnormal_chromosome_stability4.54471757
5MP0003111_abnormal_nucleus_morphology4.09095663
6MP0004957_abnormal_blastocyst_morpholog4.07992886
7MP0008057_abnormal_DNA_replication3.93552958
8MP0003123_paternal_imprinting3.92134492
9MP0003077_abnormal_cell_cycle3.53975572
10MP0008058_abnormal_DNA_repair3.40598970
11MP0008004_abnormal_stomach_pH3.40230598
12MP0005058_abnormal_lysosome_morphology2.97439831
13MP0003183_abnormal_peptide_metabolism2.91045013
14MP0003786_premature_aging2.81710454
15MP0008007_abnormal_cellular_replicative2.66011876
16MP0002736_abnormal_nociception_after2.57997658
17MP0010352_gastrointestinal_tract_polyps2.53608501
18MP0001730_embryonic_growth_arrest2.52945300
19MP0003303_peritoneal_inflammation2.48692854
20MP0000343_altered_response_to2.45426605
21MP0001968_abnormal_touch/_nociception2.43890908
22MP0008932_abnormal_embryonic_tissue2.43383037
23MP0008995_early_reproductive_senescence2.41719859
24MP0003724_increased_susceptibility_to2.39874519
25* MP0002210_abnormal_sex_determination2.37106357
26MP0000350_abnormal_cell_proliferation2.27537701
27MP0002733_abnormal_thermal_nociception2.26549896
28MP0003787_abnormal_imprinting2.15018444
29MP0003136_yellow_coat_color2.13768573
30MP0003718_maternal_effect2.08549079
31MP0005423_abnormal_somatic_nervous2.01781901
32MP0003879_abnormal_hair_cell1.98684695
33MP0003121_genomic_imprinting1.94917432
34MP0003890_abnormal_embryonic-extraembry1.93976787
35MP0005083_abnormal_biliary_tract1.91146221
36MP0001970_abnormal_pain_threshold1.90438608
37MP0003172_abnormal_lysosome_physiology1.90005590
38* MP0001145_abnormal_male_reproductive1.89319919
39* MP0001929_abnormal_gametogenesis1.88404502
40MP0003806_abnormal_nucleotide_metabolis1.86342954
41MP0008874_decreased_physiological_sensi1.85654399
42MP0001672_abnormal_embryogenesis/_devel1.85321927
43MP0005380_embryogenesis_phenotype1.85321927
44MP0004510_myositis1.84850919
45MP0000230_abnormal_systemic_arterial1.79240157
46MP0003941_abnormal_skin_development1.78213622
47* MP0000653_abnormal_sex_gland1.72659117
48MP0001835_abnormal_antigen_presentation1.71247709
49MP0003984_embryonic_growth_retardation1.69468054
50MP0005167_abnormal_blood-brain_barrier1.69170744
51MP0001697_abnormal_embryo_size1.68623636
52MP0004197_abnormal_fetal_growth/weight/1.62902132
53MP0002088_abnormal_embryonic_growth/wei1.62618562
54MP0002148_abnormal_hypersensitivity_rea1.59921108
55MP0002085_abnormal_embryonic_tissue1.59767036
56MP0005646_abnormal_pituitary_gland1.59746044
57MP0003880_abnormal_central_pattern1.58721477
58MP0005410_abnormal_fertilization1.58429384
59MP0002132_abnormal_respiratory_system1.58179283
60MP0003635_abnormal_synaptic_transmissio1.57092632
61MP0005084_abnormal_gallbladder_morpholo1.55376214
62MP0002063_abnormal_learning/memory/cond1.54198879
63MP0009764_decreased_sensitivity_to1.52993081
64MP0002735_abnormal_chemical_nociception1.52576733
65MP0004130_abnormal_muscle_cell1.52045928
66MP0001293_anophthalmia1.51432980
67MP0002084_abnormal_developmental_patter1.51429976
68MP0004859_abnormal_synaptic_plasticity1.49109367
69MP0003119_abnormal_digestive_system1.48211218
70MP0005671_abnormal_response_to1.47422419
71MP0002080_prenatal_lethality1.45632542
72MP0002653_abnormal_ependyma_morphology1.41790669
73MP0000313_abnormal_cell_death1.41675435
74MP0010307_abnormal_tumor_latency1.40795208
75MP0000465_gastrointestinal_hemorrhage1.40719072
76MP0003436_decreased_susceptibility_to1.40298445
77MP0002572_abnormal_emotion/affect_behav1.38742906
78MP0002086_abnormal_extraembryonic_tissu1.33854681
79MP0005397_hematopoietic_system_phenotyp1.33281511
80MP0001545_abnormal_hematopoietic_system1.33281511
81MP0005000_abnormal_immune_tolerance1.32116286
82MP0002102_abnormal_ear_morphology1.31072367
83MP0002064_seizures1.30864603
84MP0003638_abnormal_response/metabolism_1.29477477
85* MP0001119_abnormal_female_reproductive1.29103356
86MP0006292_abnormal_olfactory_placode1.28876863
87MP0000490_abnormal_crypts_of1.27937138
88MP0009840_abnormal_foam_cell1.27640700
89MP0004133_heterotaxia1.26571075
90MP0002272_abnormal_nervous_system1.25998650
91MP0003283_abnormal_digestive_organ1.24651993
92MP0001986_abnormal_taste_sensitivity1.24139176
93MP0008872_abnormal_physiological_respon1.23586753
94MP0002019_abnormal_tumor_incidence1.23431405
95MP0002723_abnormal_immune_serum1.19602608
96MP0009053_abnormal_anal_canal1.18259056
97MP0005076_abnormal_cell_differentiation1.16919605
98MP0003315_abnormal_perineum_morphology1.15793086
99MP0002396_abnormal_hematopoietic_system1.15663262
100MP0005365_abnormal_bile_salt1.15275613
101* MP0003698_abnormal_male_reproductive1.14636552
102MP0001663_abnormal_digestive_system1.13471417
103MP0001905_abnormal_dopamine_level1.08927645
104MP0010329_abnormal_lipoprotein_level1.08927161
105MP0001800_abnormal_humoral_immune1.08103600
106MP0002452_abnormal_antigen_presenting1.07980354
107MP0003567_abnormal_fetal_cardiomyocyte1.06874697
108MP0010155_abnormal_intestine_physiology1.05599826
109MP0004808_abnormal_hematopoietic_stem1.04936960
110MP0002160_abnormal_reproductive_system1.04791435
111MP0009672_abnormal_birth_weight1.03110507
112MP0006276_abnormal_autonomic_nervous1.01931038
113MP0005174_abnormal_tail_pigmentation1.01809377
114MP0006035_abnormal_mitochondrial_morpho0.98499530
115MP0009745_abnormal_behavioral_response0.96745096
116* MP0002161_abnormal_fertility/fecundity0.96054329
117MP0000703_abnormal_thymus_morphology0.93417409
118MP0002419_abnormal_innate_immunity0.92142743
119MP0001533_abnormal_skeleton_physiology0.90244011
120MP0002420_abnormal_adaptive_immunity0.89933320
121MP0002111_abnormal_tail_morphology0.89793698
122MP0009278_abnormal_bone_marrow0.89013335
123MP0005535_abnormal_body_temperature0.88921953
124MP0003705_abnormal_hypodermis_morpholog0.88012705
125MP0005025_abnormal_response_to0.87926726
126MP0001819_abnormal_immune_cell0.87590169
127MP0003075_altered_response_to0.84019363
128MP0010030_abnormal_orbit_morphology0.83669281
129* MP0003699_abnormal_female_reproductive0.82814784
130MP0003937_abnormal_limbs/digits/tail_de0.82237145
131MP0000015_abnormal_ear_pigmentation0.81822735
132MP0003763_abnormal_thymus_physiology0.81542356
133MP0005384_cellular_phenotype0.81421877
134MP0005551_abnormal_eye_electrophysiolog0.81307194
135MP0001845_abnormal_inflammatory_respons0.81016277
136MP0005389_reproductive_system_phenotype0.80148432
137MP0002139_abnormal_hepatobiliary_system0.79755197
138MP0001879_abnormal_lymphatic_vessel0.78662955
139MP0005394_taste/olfaction_phenotype0.77902981
140MP0005499_abnormal_olfactory_system0.77902981
141MP0002067_abnormal_sensory_capabilities0.76821637
142MP0005621_abnormal_cell_physiology0.76671279
143MP0001286_abnormal_eye_development0.76173254
144MP0009642_abnormal_blood_homeostasis0.74464420
145MP0004885_abnormal_endolymph0.74099460
146MP0003186_abnormal_redox_activity0.73179362
147MP0002429_abnormal_blood_cell0.72761225
148MP0003632_abnormal_nervous_system0.71890332
149MP0001849_ear_inflammation0.71165424
150MP0005266_abnormal_metabolism0.70232263
151MP0000716_abnormal_immune_system0.70080826
152MP0009333_abnormal_splenocyte_physiolog0.68630110
153MP0002751_abnormal_autonomic_nervous0.67683682
154MP0002332_abnormal_exercise_endurance0.67559071
155MP0003631_nervous_system_phenotype0.67464037
156MP0001915_intracranial_hemorrhage0.66219787
157MP0001756_abnormal_urination0.66163618
158MP0005387_immune_system_phenotype0.65847056
159MP0001790_abnormal_immune_system0.65847056
160MP0000049_abnormal_middle_ear0.65469802
161MP0002269_muscular_atrophy0.65148929
162MP0009703_decreased_birth_body0.64687130
163MP0001664_abnormal_digestion0.64588170
164MP0002398_abnormal_bone_marrow0.64105768
165MP0008260_abnormal_autophagy0.63850761
166MP0002557_abnormal_social/conspecific_i0.63833682
167MP0000689_abnormal_spleen_morphology0.63603452
168MP0003755_abnormal_palate_morphology0.63031901
169MP0004947_skin_inflammation0.62844454
170MP0003936_abnormal_reproductive_system0.62462310
171MP0003861_abnormal_nervous_system0.61694773
172MP0000249_abnormal_blood_vessel0.61475874
173MP0005023_abnormal_wound_healing0.61005834
174MP0000358_abnormal_cell_content/0.60960559
175MP0009780_abnormal_chondrocyte_physiolo0.60830575
176MP0000432_abnormal_head_morphology0.60797775
177MP0002722_abnormal_immune_system0.60069942
178MP0003942_abnormal_urinary_system0.59159491
179MP0005367_renal/urinary_system_phenotyp0.58981106
180MP0000516_abnormal_urinary_system0.58981106
181MP0001529_abnormal_vocalization0.58859667
182MP0002114_abnormal_axial_skeleton0.55453944
183MP0003115_abnormal_respiratory_system0.54559081
184MP0003448_altered_tumor_morphology0.53723807
185MP0001919_abnormal_reproductive_system0.53699532
186MP0005395_other_phenotype0.53182705
187MP0000477_abnormal_intestine_morphology0.52397625
188MP0003566_abnormal_cell_adhesion0.52021667
189MP0005408_hypopigmentation0.50612402
190MP0002116_abnormal_craniofacial_bone0.49350915
191MP0002697_abnormal_eye_size0.49335496

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)8.97700709
2Purpura (HP:0000979)7.65165111
3Petechiae (HP:0000967)7.49172391
4Menorrhagia (HP:0000132)7.44410489
5Increased mean platelet volume (HP:0011877)6.99156425
6Abnormal platelet volume (HP:0011876)6.67104747
7Epistaxis (HP:0000421)5.68025229
8Hyperlipoproteinemia (HP:0010980)5.17336971
9Dyschromatopsia (HP:0007641)4.80769746
10Birth length less than 3rd percentile (HP:0003561)4.67976552
11Abnormality of the anterior horn cell (HP:0006802)4.33819060
12Degeneration of anterior horn cells (HP:0002398)4.33819060
13Gingival bleeding (HP:0000225)4.21858458
14Carpal bone hypoplasia (HP:0001498)4.10711254
15Abnormal platelet function (HP:0011869)3.84582193
16Impaired platelet aggregation (HP:0003540)3.84582193
17Patellar aplasia (HP:0006443)3.81843167
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.81153464
19Breast hypoplasia (HP:0003187)3.71636349
20Abnormality of the heme biosynthetic pathway (HP:0010472)3.52835227
21Aplasia/Hypoplasia of the patella (HP:0006498)3.45998535
22Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.40853633
23Spontaneous hematomas (HP:0007420)3.40653038
24Abnormality of macrophages (HP:0004311)3.38668229
25Ependymoma (HP:0002888)3.33993167
26Chromsome breakage (HP:0040012)3.32240698
27Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.27077120
28Decreased central vision (HP:0007663)3.23071868
29Abnormality of the labia minora (HP:0012880)3.10578091
30Abnormality of the lower motor neuron (HP:0002366)3.10539267
31Poikilocytosis (HP:0004447)3.08977405
32Colon cancer (HP:0003003)3.06759236
33Atrophy/Degeneration involving motor neurons (HP:0007373)3.04554353
34Absent radius (HP:0003974)3.03711060
35Medulloblastoma (HP:0002885)2.95251659
36Polyphagia (HP:0002591)2.95048785
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.94966251
38Rectovaginal fistula (HP:0000143)2.94496080
39Rectal fistula (HP:0100590)2.94496080
403-Methylglutaconic aciduria (HP:0003535)2.92903196
41Absent thumb (HP:0009777)2.92461543
42Irregular epiphyses (HP:0010582)2.90027181
43Abnormality of the vasculature of the conjunctiva (HP:0008054)2.88771358
44Intestinal fistula (HP:0100819)2.84981658
45Abnormality of lateral ventricle (HP:0030047)2.83697305
46Conjunctival telangiectasia (HP:0000524)2.83211921
47Absent forearm bone (HP:0003953)2.81693990
48Aplasia involving forearm bones (HP:0009822)2.81693990
49Metaphyseal cupping (HP:0003021)2.81115680
50Abnormal rod and cone electroretinograms (HP:0008323)2.76100451
51Impulsivity (HP:0100710)2.75097145
52Agnosia (HP:0010524)2.74549813
53Generalized aminoaciduria (HP:0002909)2.71444478
54Selective tooth agenesis (HP:0001592)2.68799699
55Basal cell carcinoma (HP:0002671)2.68401671
56Visual hallucinations (HP:0002367)2.68197134
57Abnormal lung lobation (HP:0002101)2.65745556
58Rhabdomyosarcoma (HP:0002859)2.65272192
59Acanthocytosis (HP:0001927)2.62704674
60Abnormal spermatogenesis (HP:0008669)2.62507448
61Horseshoe kidney (HP:0000085)2.62182236
62Hyperthyroidism (HP:0000836)2.58914983
63Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.58544793
64Oral leukoplakia (HP:0002745)2.58122121
65Upper limb muscle weakness (HP:0003484)2.57996546
66Paralysis (HP:0003470)2.57676969
67Bruising susceptibility (HP:0000978)2.56686687
68Abnormality of glycolipid metabolism (HP:0010969)2.55761952
69Abnormality of liposaccharide metabolism (HP:0010968)2.55761952
70Abnormality of glycosphingolipid metabolism (HP:0004343)2.55761952
71Shawl scrotum (HP:0000049)2.54495698
72Stenosis of the external auditory canal (HP:0000402)2.51825021
73Aplasia/Hypoplasia of the sternum (HP:0006714)2.50648945
74Abnormal number of incisors (HP:0011064)2.50531953
75Biliary tract neoplasm (HP:0100574)2.49260728
76Hyperventilation (HP:0002883)2.48632760
77Chronic obstructive pulmonary disease (HP:0006510)2.48128944
78Obstructive lung disease (HP:0006536)2.48128944
79Azoospermia (HP:0000027)2.48045240
80Increased cerebral lipofuscin (HP:0011813)2.47048908
81Aplasia/Hypoplasia involving the musculature (HP:0001460)2.46355690
82Supernumerary spleens (HP:0009799)2.44510473
83Facial cleft (HP:0002006)2.43828856
84Cleft eyelid (HP:0000625)2.43010158
85Abnormality of chromosome stability (HP:0003220)2.42364421
86Lissencephaly (HP:0001339)2.41252671
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.39886684
88Ectopic kidney (HP:0000086)2.38784278
89Protruding tongue (HP:0010808)2.38347351
90Tongue fasciculations (HP:0001308)2.37849029
91Vaginal fistula (HP:0004320)2.36528747
92Hepatosplenomegaly (HP:0001433)2.35978561
93Spinal muscular atrophy (HP:0007269)2.35881091
94Cerebral hypomyelination (HP:0006808)2.33174173
95Xanthomatosis (HP:0000991)2.30626739
96Abnormality of the astrocytes (HP:0100707)2.30143195
97Astrocytoma (HP:0009592)2.30143195
98Aplasia/hypoplasia of the humerus (HP:0006507)2.28814855
99Shoulder girdle muscle weakness (HP:0003547)2.28078093
100Dysostosis multiplex (HP:0000943)2.27881379
101Abolished electroretinogram (ERG) (HP:0000550)2.27247745
102Increased density of long bones (HP:0006392)2.24504966
103Abnormal eating behavior (HP:0100738)2.24088494
104Abnormal hair whorl (HP:0010721)2.24031680
105Capillary hemangiomas (HP:0005306)2.22739961
106Premature ovarian failure (HP:0008209)2.20829128
107Ventricular fibrillation (HP:0001663)2.20039315
108Facial hemangioma (HP:0000329)2.19310123
109Abnormality of iron homeostasis (HP:0011031)2.18738666
110Small intestinal stenosis (HP:0012848)2.18196032
111Duodenal stenosis (HP:0100867)2.18196032
112Meckel diverticulum (HP:0002245)2.13756069
113Abdominal situs inversus (HP:0003363)2.13098589
114Abnormality of abdominal situs (HP:0011620)2.13098589
115Increased serum ferritin (HP:0003281)2.12713175
116Anal stenosis (HP:0002025)2.12553256
117Abnormal biliary tract morphology (HP:0012440)2.12122340
118Abnormality of transition element cation homeostasis (HP:0011030)2.11668569
119Vacuolated lymphocytes (HP:0001922)2.10785891
120Stomatitis (HP:0010280)2.09253446
121Male infertility (HP:0003251)2.08921761
122Joint swelling (HP:0001386)2.08872378
123Nausea (HP:0002018)2.08668017
124Muscle fibrillation (HP:0010546)2.08622111
125Rough bone trabeculation (HP:0100670)2.05941924
126Abnormality of the ileum (HP:0001549)2.05329294
127Recurrent bacterial skin infections (HP:0005406)2.04964850
128Nephroblastoma (Wilms tumor) (HP:0002667)2.02528172
129Cellular immunodeficiency (HP:0005374)2.00738857
130Esophageal atresia (HP:0002032)1.99603611
131Neoplasm of the pancreas (HP:0002894)1.98045877
132Breast aplasia (HP:0100783)1.97019424
133Neoplasm of striated muscle (HP:0009728)1.95141623
134Short humerus (HP:0005792)1.95017601
135Abnormality of the duodenum (HP:0002246)1.93649165
136Pseudobulbar signs (HP:0002200)1.93227862
137Eczematoid dermatitis (HP:0000976)1.92709424
138Dynein arm defect of respiratory motile cilia (HP:0012255)1.91993326
139Absent/shortened dynein arms (HP:0200106)1.91993326
140Glioma (HP:0009733)1.91148965
141Renal Fanconi syndrome (HP:0001994)1.90579379
142Recurrent abscess formation (HP:0002722)1.89321189
143Large eyes (HP:0001090)1.89212066
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.89037191
145Reticulocytopenia (HP:0001896)1.87897266
146Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87307018
147Abnormality of binocular vision (HP:0011514)1.86936182
148Diplopia (HP:0000651)1.86936182
149Microretrognathia (HP:0000308)1.85677869
150Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85236782
151Absent epiphyses (HP:0010577)1.85236782
152Genu varum (HP:0002970)1.85059873
153Cafe-au-lait spot (HP:0000957)1.84257968
154Postural tremor (HP:0002174)1.83596696
155Squamous cell carcinoma (HP:0002860)1.83567678
156Metaphyseal dysplasia (HP:0100255)1.83559554
157High anterior hairline (HP:0009890)1.83404042
158Abnormality of the preputium (HP:0100587)1.82811892
159Dysautonomia (HP:0002459)1.82722736
160Encephalitis (HP:0002383)1.80728886
161Atresia of the external auditory canal (HP:0000413)1.80621489
162Premature graying of hair (HP:0002216)1.80423173
163Agitation (HP:0000713)1.80106525
164Short thumb (HP:0009778)1.79368998
165Aplasia/Hypoplasia of the breasts (HP:0010311)1.78983275
166Embryonal renal neoplasm (HP:0011794)1.78826560
167Neoplasm of the colon (HP:0100273)1.77484680
168Fused cervical vertebrae (HP:0002949)1.76687509
169Vitreoretinal degeneration (HP:0000655)1.76287981
170Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75645973
171Hypoplasia of the brainstem (HP:0002365)1.75645973
172Myelodysplasia (HP:0002863)1.74968390
17311 pairs of ribs (HP:0000878)1.73962691
174Joint hemorrhage (HP:0005261)1.73909937
175Oligodactyly (HP:0012165)1.73599751
176Loss of speech (HP:0002371)1.73304768
177Delusions (HP:0000746)1.71863242
178Increased IgM level (HP:0003496)1.71432220
179Gastrointestinal atresia (HP:0002589)1.70676575
180Cystic hygroma (HP:0000476)1.69881021
181Hypochromic anemia (HP:0001931)1.69516386
182Abnormality of alanine metabolism (HP:0010916)1.68612414
183Hyperalaninemia (HP:0003348)1.68612414
184Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68612414
185Abnormality of magnesium homeostasis (HP:0004921)1.64301788
186Abnormal respiratory epithelium morphology (HP:0012253)1.64233550
187Abnormal respiratory motile cilium morphology (HP:0005938)1.64233550
188Intellectual disability, profound (HP:0002187)1.63716854
189Tinnitus (HP:0000360)1.63026515
190Pachygyria (HP:0001302)1.61671849
191Mutism (HP:0002300)1.61521307
192Thyroid-stimulating hormone excess (HP:0002925)1.61024404
193Basal ganglia calcification (HP:0002135)1.58173767
194Abnormal ciliary motility (HP:0012262)1.57660384
195Abnormality of the common coagulation pathway (HP:0010990)1.56886888
196Left ventricular hypertrophy (HP:0001712)1.56546232
197Medial flaring of the eyebrow (HP:0010747)1.54052058
198Abnormal pupillary function (HP:0007686)1.53728778
199Cheilitis (HP:0100825)1.53532219
200Abnormal hemoglobin (HP:0011902)1.52700762

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.94799522
2BUB14.21789345
3RIPK43.94734408
4EIF2AK13.88599206
5MAP3K43.69997141
6CDK123.69677671
7BRSK23.40797085
8TYRO33.18044127
9WEE12.86978094
10ACVR1B2.79730938
11MKNK12.48794852
12TSSK62.46144372
13PTK2B2.41157941
14FGR2.36287699
15MKNK22.26196476
16PLK12.25800434
17TTK2.15058205
18BTK2.09307244
19PLK32.08283135
20BRSK12.07622563
21FES2.07017407
22MATK2.06687336
23TNK22.02984535
24MST42.02585928
25IRAK42.01640500
26ADRBK21.99138959
27PLK41.97951965
28NEK21.96246969
29EIF2AK31.95451652
30SRPK11.92803424
31RPS6KA41.90219180
32CSF1R1.80137736
33TAOK31.77929276
34NEK11.77611136
35TEC1.76293599
36GRK51.74642573
37PNCK1.74487215
38SYK1.73148829
39MAP3K111.70166579
40ATR1.63917506
41MAPK131.63850955
42STK38L1.63716910
43CHEK21.62319915
44BRD41.58781957
45WNK41.58062740
46CDK71.56842091
47WNK31.54560398
48MYLK1.45021413
49CHEK11.43885281
50AURKB1.40751325
51ILK1.38240006
52STK101.32097091
53BLK1.30837895
54AURKA1.28135744
55PKN11.27909735
56ZAP701.26762259
57STK241.25200801
58EPHA21.23232671
59CCNB11.22733939
60DAPK21.21020077
61EPHB21.20534278
62PIM11.19914406
63DDR21.17694868
64ALK1.16855107
65HCK1.10131712
66MAPKAPK31.09587233
67CDK41.09281732
68PLK21.06511607
69LYN1.03342073
70PIM21.02037512
71DAPK31.00407090
72RPS6KB21.00349990
73ATM1.00177315
74CDK20.99364026
75MAP3K100.98658583
76PDK40.95854228
77PDK30.95854228
78PRKD30.94314768
79STK40.94176612
80MAP2K70.92425163
81MELK0.91926789
82TAOK10.91904153
83DYRK20.91302738
84MAP3K80.90546012
85IKBKB0.88274461
86NTRK30.87555122
87TAOK20.85452225
88GRK10.85411224
89SIK20.84876366
90PBK0.84738876
91MAP3K30.81893995
92NME10.81106070
93CDK10.80538283
94PRPF4B0.79733539
95CSK0.79680112
96STK30.79338387
97LATS20.78096020
98VRK10.77251927
99CDK80.76559150
100PASK0.76179978
101CAMKK20.75753069
102MAP2K30.73862357
103NTRK20.73782700
104LATS10.70407176
105CAMK1G0.70336336
106CSNK2A20.70237740
107PKN20.70234608
108MARK30.69273286
109PRKD20.69067835
110MAPK120.65399071
111PRKD10.64499206
112MAP2K40.64486383
113MINK10.63766464
114PAK40.62827289
115IRAK30.62226840
116PRKCG0.61268173
117PRKCI0.61141748
118CHUK0.61075744
119CAMKK10.60911108
120CSNK2A10.60180478
121MAP4K20.58871460
122AKT30.57156500
123DAPK10.56003835
124EEF2K0.55884881
125TLK10.54399835
126EPHB10.53037307
127RPS6KA20.52739165
128CDK190.52338923
129CDK140.51307609
130STK160.50981374
131CSNK1E0.50455290
132EIF2AK20.50406112
133MAP3K50.49611769
134PDK20.48990367
135MARK10.48827514
136SIK30.48345285
137CAMK10.47778337
138DYRK30.47573231
139CDK60.47132787
140PAK60.46594916
141CDK50.46142068
142PRKCZ0.45741546
143PRKDC0.45548860
144FYN0.44692237
145PRKCQ0.43645571
146PIK3CG0.42750550
147MAP4K10.42252708
148RPS6KB10.42240344
149RPS6KA50.41932826
150ADRBK10.41678057
151PAK10.40994181
152MTOR0.39765075
153LRRK20.37567327
154NUAK10.36604646
155MAPK140.36564160
156NME20.36425068
157GRK60.35792671
158ERBB20.35264188
159PRKACG0.34235652
160BMX0.33156140
161GSK3B0.32958647
162DYRK1B0.32159210
163ABL20.31874545
164PDGFRB0.31483339
165EPHA40.30931718
166TESK10.29688459
167CSNK1D0.29397699
168FGFR10.28941031
169TESK20.27575405
170CDC42BPA0.27507307
171AKT20.27019712
172MAPK100.26436186
173BMPR20.26365190
174KSR10.26352428
175MAPK110.25871279
176RPS6KA10.25311682
177AKT10.20775642
178ZAK0.20602898
179MAPK10.20461866
180TGFBR10.19910450

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.14889735
2DNA replication_Homo sapiens_hsa030304.69052630
3Mismatch repair_Homo sapiens_hsa034304.51498819
4Platelet activation_Homo sapiens_hsa046113.65091542
5RNA transport_Homo sapiens_hsa030133.58816720
6Spliceosome_Homo sapiens_hsa030403.36034014
7Homologous recombination_Homo sapiens_hsa034403.23425903
8One carbon pool by folate_Homo sapiens_hsa006703.07632707
9RNA polymerase_Homo sapiens_hsa030203.07190788
10Proteasome_Homo sapiens_hsa030503.03863915
11Base excision repair_Homo sapiens_hsa034102.83802993
12Cell cycle_Homo sapiens_hsa041102.78070413
13mRNA surveillance pathway_Homo sapiens_hsa030152.72599081
14Nucleotide excision repair_Homo sapiens_hsa034202.67860855
15Basal transcription factors_Homo sapiens_hsa030222.56253088
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.53201024
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.44412094
18SNARE interactions in vesicular transport_Homo sapiens_hsa041302.39844171
19Fanconi anemia pathway_Homo sapiens_hsa034602.37735408
20Sulfur relay system_Homo sapiens_hsa041222.33704381
21Ribosome_Homo sapiens_hsa030102.28287360
22Collecting duct acid secretion_Homo sapiens_hsa049662.16907134
23RNA degradation_Homo sapiens_hsa030182.12368665
24Non-homologous end-joining_Homo sapiens_hsa034501.98967969
25Pyrimidine metabolism_Homo sapiens_hsa002401.97684377
26Hematopoietic cell lineage_Homo sapiens_hsa046401.88228423
27Gap junction_Homo sapiens_hsa045401.75413295
28Lysosome_Homo sapiens_hsa041421.70499421
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.67688197
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.61156589
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.50542950
32Synaptic vesicle cycle_Homo sapiens_hsa047211.50352082
33Endocytosis_Homo sapiens_hsa041441.45625108
34Arachidonic acid metabolism_Homo sapiens_hsa005901.45468066
35Chemokine signaling pathway_Homo sapiens_hsa040621.45286861
36p53 signaling pathway_Homo sapiens_hsa041151.43394198
37Glutamatergic synapse_Homo sapiens_hsa047241.40224180
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39890398
39Phenylalanine metabolism_Homo sapiens_hsa003601.39871662
40Morphine addiction_Homo sapiens_hsa050321.34001676
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.32478425
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30594787
43Phagosome_Homo sapiens_hsa041451.27974951
44Asthma_Homo sapiens_hsa053101.27614642
45GABAergic synapse_Homo sapiens_hsa047271.27040610
46Epstein-Barr virus infection_Homo sapiens_hsa051691.25611922
47Oocyte meiosis_Homo sapiens_hsa041141.24430186
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24364779
49Serotonergic synapse_Homo sapiens_hsa047261.24252153
50Osteoclast differentiation_Homo sapiens_hsa043801.24131126
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.21726910
52beta-Alanine metabolism_Homo sapiens_hsa004101.21277462
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20034230
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17581004
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17170446
56B cell receptor signaling pathway_Homo sapiens_hsa046621.16214526
57Circadian entrainment_Homo sapiens_hsa047131.15064860
58Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13353460
59Olfactory transduction_Homo sapiens_hsa047401.13049209
60Alcoholism_Homo sapiens_hsa050341.12192735
61Rheumatoid arthritis_Homo sapiens_hsa053231.11017123
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08083123
63Staphylococcus aureus infection_Homo sapiens_hsa051501.05146334
64Phospholipase D signaling pathway_Homo sapiens_hsa040721.04378150
65Nicotine addiction_Homo sapiens_hsa050331.03561184
66Purine metabolism_Homo sapiens_hsa002301.03366897
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02558918
68Cysteine and methionine metabolism_Homo sapiens_hsa002701.00676696
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00113801
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99608132
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98721508
72Tuberculosis_Homo sapiens_hsa051520.96679993
73VEGF signaling pathway_Homo sapiens_hsa043700.92886532
74Biosynthesis of amino acids_Homo sapiens_hsa012300.91427250
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91210907
76Nitrogen metabolism_Homo sapiens_hsa009100.91174698
77Dopaminergic synapse_Homo sapiens_hsa047280.91168593
78Allograft rejection_Homo sapiens_hsa053300.90322689
79HTLV-I infection_Homo sapiens_hsa051660.89020703
80Herpes simplex infection_Homo sapiens_hsa051680.88547255
81Phototransduction_Homo sapiens_hsa047440.88178911
82Salmonella infection_Homo sapiens_hsa051320.87977590
83Calcium signaling pathway_Homo sapiens_hsa040200.86623949
84Selenocompound metabolism_Homo sapiens_hsa004500.85847153
85Cocaine addiction_Homo sapiens_hsa050300.85505898
86Thyroid cancer_Homo sapiens_hsa052160.85178801
87Viral carcinogenesis_Homo sapiens_hsa052030.84747010
88MicroRNAs in cancer_Homo sapiens_hsa052060.79591098
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.78901108
90Glycerolipid metabolism_Homo sapiens_hsa005610.78260325
91Type I diabetes mellitus_Homo sapiens_hsa049400.73425956
92Rap1 signaling pathway_Homo sapiens_hsa040150.73041999
93Sphingolipid metabolism_Homo sapiens_hsa006000.72553623
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71835015
95Tyrosine metabolism_Homo sapiens_hsa003500.71657559
96TGF-beta signaling pathway_Homo sapiens_hsa043500.66329035
97Graft-versus-host disease_Homo sapiens_hsa053320.65795018
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65239980
99Other glycan degradation_Homo sapiens_hsa005110.65087176
100Regulation of autophagy_Homo sapiens_hsa041400.64675776
101Ras signaling pathway_Homo sapiens_hsa040140.62098791
102MAPK signaling pathway_Homo sapiens_hsa040100.61109970
103Sulfur metabolism_Homo sapiens_hsa009200.60103497
104Hippo signaling pathway_Homo sapiens_hsa043900.58577505
105Cholinergic synapse_Homo sapiens_hsa047250.56884992
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54821525
107Malaria_Homo sapiens_hsa051440.54661101
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.53786089
109Pancreatic secretion_Homo sapiens_hsa049720.52326692
110Steroid biosynthesis_Homo sapiens_hsa001000.51642591
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51516964
112Small cell lung cancer_Homo sapiens_hsa052220.50841202
113Bladder cancer_Homo sapiens_hsa052190.50196561
114Taste transduction_Homo sapiens_hsa047420.49864789
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49371962
116Axon guidance_Homo sapiens_hsa043600.49207502
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48884985
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.48053559
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46865678
120Glutathione metabolism_Homo sapiens_hsa004800.46644233
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46630188
122Amphetamine addiction_Homo sapiens_hsa050310.45768395
123Notch signaling pathway_Homo sapiens_hsa043300.44621736
124Oxytocin signaling pathway_Homo sapiens_hsa049210.44244357
125Autoimmune thyroid disease_Homo sapiens_hsa053200.43841911
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43139011
127Colorectal cancer_Homo sapiens_hsa052100.43011602
128Systemic lupus erythematosus_Homo sapiens_hsa053220.42727559
129Antigen processing and presentation_Homo sapiens_hsa046120.42084738
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.42068179
131Apoptosis_Homo sapiens_hsa042100.41845132
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41643019
133mTOR signaling pathway_Homo sapiens_hsa041500.41434425
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41187589
135ECM-receptor interaction_Homo sapiens_hsa045120.40732492
136Carbon metabolism_Homo sapiens_hsa012000.39706522
137Acute myeloid leukemia_Homo sapiens_hsa052210.39684226
138Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38244794
139Leishmaniasis_Homo sapiens_hsa051400.36455341
140Lysine degradation_Homo sapiens_hsa003100.36151618
141Gastric acid secretion_Homo sapiens_hsa049710.35884540
142Chemical carcinogenesis_Homo sapiens_hsa052040.35824477
143HIF-1 signaling pathway_Homo sapiens_hsa040660.35811496
144Basal cell carcinoma_Homo sapiens_hsa052170.34976574
145Drug metabolism - other enzymes_Homo sapiens_hsa009830.34326438
146Non-small cell lung cancer_Homo sapiens_hsa052230.33718620
147Influenza A_Homo sapiens_hsa051640.33223667
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33198817
149Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32703239
150Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32561525
151Central carbon metabolism in cancer_Homo sapiens_hsa052300.31948840
152Pentose phosphate pathway_Homo sapiens_hsa000300.30106914
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29226872
154Tight junction_Homo sapiens_hsa045300.29119104
155Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27970261
156Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27493308
157Hedgehog signaling pathway_Homo sapiens_hsa043400.27392871
158T cell receptor signaling pathway_Homo sapiens_hsa046600.26995103
159NF-kappa B signaling pathway_Homo sapiens_hsa040640.26790389
160Prostate cancer_Homo sapiens_hsa052150.26745027
161Huntingtons disease_Homo sapiens_hsa050160.26318430
162Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24365466
163Primary immunodeficiency_Homo sapiens_hsa053400.24353457
164Adherens junction_Homo sapiens_hsa045200.21506491
165Chronic myeloid leukemia_Homo sapiens_hsa052200.21048000
166Wnt signaling pathway_Homo sapiens_hsa043100.20668809
167Vitamin B6 metabolism_Homo sapiens_hsa007500.20219460
168Pathways in cancer_Homo sapiens_hsa052000.18863862
169Endometrial cancer_Homo sapiens_hsa052130.18838913
170Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18750425
171Dorso-ventral axis formation_Homo sapiens_hsa043200.17601722
172Legionellosis_Homo sapiens_hsa051340.17373534
173Linoleic acid metabolism_Homo sapiens_hsa005910.16953712
174Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16520390
175Shigellosis_Homo sapiens_hsa051310.15722287
176Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14706216
177Renal cell carcinoma_Homo sapiens_hsa052110.12863622
178Measles_Homo sapiens_hsa051620.10960049
179Pyruvate metabolism_Homo sapiens_hsa006200.10718469
180Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.10610555
1812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.10183398
182ErbB signaling pathway_Homo sapiens_hsa040120.09945743
183Fructose and mannose metabolism_Homo sapiens_hsa000510.09924792
184Long-term potentiation_Homo sapiens_hsa047200.08896454
185Pancreatic cancer_Homo sapiens_hsa052120.08894818

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