ZGRF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The encoded protein contains GRF zinc finger (zf-GRF) and transmembrane domains. GRF zinc fingers are found in a number of DNA-binding proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.32603300
2protein localization to kinetochore (GO:0034501)5.13203485
3kinetochore organization (GO:0051383)5.07887858
4mitotic sister chromatid cohesion (GO:0007064)5.02604731
5nuclear pore complex assembly (GO:0051292)4.99007599
6DNA strand elongation involved in DNA replication (GO:0006271)4.95253170
7DNA replication initiation (GO:0006270)4.89818309
8nuclear pore organization (GO:0006999)4.87927775
9telomere maintenance via semi-conservative replication (GO:0032201)4.84796554
10CENP-A containing nucleosome assembly (GO:0034080)4.84668522
11chromatin remodeling at centromere (GO:0031055)4.82578241
12mitotic chromosome condensation (GO:0007076)4.78907199
13DNA strand elongation (GO:0022616)4.73888092
14DNA replication checkpoint (GO:0000076)4.71563545
15mitotic recombination (GO:0006312)4.70713023
16telomere maintenance via recombination (GO:0000722)4.64813172
17protein localization to chromosome, centromeric region (GO:0071459)4.51449700
18DNA replication-independent nucleosome assembly (GO:0006336)4.43077563
19DNA replication-independent nucleosome organization (GO:0034724)4.43077563
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.37002059
21sister chromatid segregation (GO:0000819)4.34132992
22mitotic metaphase plate congression (GO:0007080)4.28585645
23meiotic chromosome segregation (GO:0045132)4.27093269
24DNA replication-dependent nucleosome assembly (GO:0006335)4.24054544
25DNA replication-dependent nucleosome organization (GO:0034723)4.24054544
26mitotic sister chromatid segregation (GO:0000070)4.23493848
27kinetochore assembly (GO:0051382)4.21686567
28histone exchange (GO:0043486)4.14897039
29attachment of spindle microtubules to kinetochore (GO:0008608)4.05299026
30regulation of DNA endoreduplication (GO:0032875)4.04320063
31metaphase plate congression (GO:0051310)4.02770249
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.99504338
33regulation of mitotic spindle checkpoint (GO:1903504)3.99504338
34telomere maintenance via telomere lengthening (GO:0010833)3.98568727
35synapsis (GO:0007129)3.91728870
36mitotic nuclear envelope disassembly (GO:0007077)3.87385527
37DNA geometric change (GO:0032392)3.86551550
38nucleotide-excision repair, DNA gap filling (GO:0006297)3.85753286
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.84526385
40DNA duplex unwinding (GO:0032508)3.84078658
41pore complex assembly (GO:0046931)3.81431764
42mitotic G2/M transition checkpoint (GO:0044818)3.80117281
43protein K6-linked ubiquitination (GO:0085020)3.72760629
44centriole replication (GO:0007099)3.71577508
45chromatin assembly or disassembly (GO:0006333)3.71306894
46translesion synthesis (GO:0019985)3.70489739
47recombinational repair (GO:0000725)3.69136329
48double-strand break repair via homologous recombination (GO:0000724)3.68692886
49establishment of chromosome localization (GO:0051303)3.66817793
50regulation of centrosome duplication (GO:0010824)3.65612221
51regulation of centriole replication (GO:0046599)3.65399092
52maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.61615411
53negative regulation of DNA-dependent DNA replication (GO:2000104)3.61052541
54membrane disassembly (GO:0030397)3.58149711
55nuclear envelope disassembly (GO:0051081)3.58149711
56regulation of nuclear cell cycle DNA replication (GO:0033262)3.57736151
57DNA ligation (GO:0006266)3.56901459
58DNA topological change (GO:0006265)3.56456982
59mismatch repair (GO:0006298)3.56272123
60regulation of histone H3-K9 methylation (GO:0051570)3.56068581
61regulation of double-strand break repair via homologous recombination (GO:0010569)3.56010010
62IMP biosynthetic process (GO:0006188)3.54709198
63telomere maintenance (GO:0000723)3.52362072
64telomere organization (GO:0032200)3.49082769
65ATP-dependent chromatin remodeling (GO:0043044)3.47283221
66DNA conformation change (GO:0071103)3.43139479
67chromosome segregation (GO:0007059)3.42996719
68nucleobase biosynthetic process (GO:0046112)3.40535718
69microtubule depolymerization (GO:0007019)3.38967893
70regulation of centrosome cycle (GO:0046605)3.37776007
71positive regulation of chromosome segregation (GO:0051984)3.37151673
72regulation of spindle organization (GO:0090224)3.35210286
73somatic diversification of immune receptors via somatic mutation (GO:0002566)3.34537331
74somatic hypermutation of immunoglobulin genes (GO:0016446)3.34537331
75non-recombinational repair (GO:0000726)3.33981464
76double-strand break repair via nonhomologous end joining (GO:0006303)3.33981464
77postreplication repair (GO:0006301)3.33744481
78positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.32325734
79positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.32325734
80positive regulation of mitotic sister chromatid separation (GO:1901970)3.32325734
81DNA synthesis involved in DNA repair (GO:0000731)3.30043131
82replication fork processing (GO:0031297)3.29927852
83spindle checkpoint (GO:0031577)3.27039956
84protein localization to chromosome (GO:0034502)3.26929445
85regulation of mitotic metaphase/anaphase transition (GO:0030071)3.26447020
86intra-S DNA damage checkpoint (GO:0031573)3.25733701
87chromosome condensation (GO:0030261)3.21204335
88regulation of chromosome segregation (GO:0051983)3.20825322
89negative regulation of DNA recombination (GO:0045910)3.20087637
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.19279216
91resolution of meiotic recombination intermediates (GO:0000712)3.19133281
92regulation of sister chromatid cohesion (GO:0007063)3.18595086
93DNA catabolic process, exonucleolytic (GO:0000738)3.17927088
94spindle assembly checkpoint (GO:0071173)3.16935116
95DNA packaging (GO:0006323)3.15380161
96DNA strand renaturation (GO:0000733)3.13170638
97sister chromatid cohesion (GO:0007062)3.13015343
98negative regulation of chromosome segregation (GO:0051985)3.12160227
99regulation of mitotic sister chromatid separation (GO:0010965)3.11257833
100regulation of mitotic sister chromatid segregation (GO:0033047)3.11257833
101regulation of sister chromatid segregation (GO:0033045)3.11257833
102purine nucleobase biosynthetic process (GO:0009113)3.11183700
103maturation of 5.8S rRNA (GO:0000460)3.10829980
104negative regulation of mitotic sister chromatid separation (GO:2000816)3.09643622
105negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09643622
106negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09643622
107negative regulation of sister chromatid segregation (GO:0033046)3.09643622
108regulation of double-strand break repair (GO:2000779)3.08978836
109regulation of helicase activity (GO:0051095)3.07313702
110DNA double-strand break processing (GO:0000729)3.04775662
111regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04710442
112negative regulation of histone methylation (GO:0031061)3.04279936
113double-strand break repair (GO:0006302)3.02274242
114dosage compensation (GO:0007549)3.01974719
115DNA recombination (GO:0006310)3.01942232
116IMP metabolic process (GO:0046040)3.01571922
117mitotic spindle assembly checkpoint (GO:0007094)3.01310547
118negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00861858
119mitotic spindle checkpoint (GO:0071174)2.99490318
120reciprocal DNA recombination (GO:0035825)2.98250830
121reciprocal meiotic recombination (GO:0007131)2.98250830
122centrosome organization (GO:0051297)2.97845605
123isotype switching (GO:0045190)2.91031107

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.84203673
2E2F4_17652178_ChIP-ChIP_JURKAT_Human5.07154108
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.88167488
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.30696449
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.76146667
6E2F1_21310950_ChIP-Seq_MCF-7_Human2.75589040
7ZNF274_21170338_ChIP-Seq_K562_Hela2.68364292
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.62023026
9AR_21909140_ChIP-Seq_LNCAP_Human2.46874461
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.41789933
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39583864
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.38464200
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34115012
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28936421
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.20547659
16MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13401689
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11704885
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10433622
19FUS_26573619_Chip-Seq_HEK293_Human2.04490267
20VDR_22108803_ChIP-Seq_LS180_Human2.00550899
21E2F7_22180533_ChIP-Seq_HELA_Human12.9070735
22MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98929839
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97060573
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94876240
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87751638
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82832388
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82040952
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.81800859
29VDR_23849224_ChIP-Seq_CD4+_Human1.80847338
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.80821743
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80446262
32IGF1R_20145208_ChIP-Seq_DFB_Human1.79452838
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79125359
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78510324
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76946370
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75955953
37FOXP3_21729870_ChIP-Seq_TREG_Human1.74345061
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73346681
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72343057
40XRN2_22483619_ChIP-Seq_HELA_Human1.70523684
41CIITA_25753668_ChIP-Seq_RAJI_Human1.70120424
42ELK1_19687146_ChIP-ChIP_HELA_Human1.67851777
43IRF1_19129219_ChIP-ChIP_H3396_Human1.62646806
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.60204706
45TAF15_26573619_Chip-Seq_HEK293_Human1.58676293
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.57918303
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52864084
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52849746
49MYC_22102868_ChIP-Seq_BL_Human1.49919049
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.48528837
51TTF2_22483619_ChIP-Seq_HELA_Human1.47414721
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45864129
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44608715
54P300_19829295_ChIP-Seq_ESCs_Human1.40298335
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40085704
56GBX2_23144817_ChIP-Seq_PC3_Human1.38630660
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37905594
58DCP1A_22483619_ChIP-Seq_HELA_Human1.36498832
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33844906
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32760138
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32573965
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32510874
63KDM5A_27292631_Chip-Seq_BREAST_Human1.32026407
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31030267
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28101280
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27368003
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27098416
68GABP_19822575_ChIP-Seq_HepG2_Human1.22156868
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20525310
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17936396
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16971052
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15004343
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14751080
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14708541
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13885855
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12152215
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11652680
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11589744
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09098918
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07843903
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06581743
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05933599
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05590743
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05523308
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05454349
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05342280
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03476374
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02480598
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99054181
90MYC_18940864_ChIP-ChIP_HL60_Human0.96189492
91TFEB_21752829_ChIP-Seq_HELA_Human0.95909166
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95626278
93ER_23166858_ChIP-Seq_MCF-7_Human0.95360635
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94485815
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94251906
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94231177
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94112546
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94112546
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93229411
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91758011
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88452104
102STAT3_23295773_ChIP-Seq_U87_Human0.88255173
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88028207
104TP53_22573176_ChIP-Seq_HFKS_Human0.87196626
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85889419
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.85871929
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84836076
108SPI1_23547873_ChIP-Seq_NB4_Human0.84793199
109CBP_20019798_ChIP-Seq_JUKART_Human0.84700261
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84700261
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83186470
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83018417
113EZH2_27294783_Chip-Seq_NPCs_Mouse0.83013755
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82382035
115KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82093376
116TCF4_23295773_ChIP-Seq_U87_Human0.81965607
117YY1_21170310_ChIP-Seq_MESCs_Mouse0.81260357
118EWS_26573619_Chip-Seq_HEK293_Human0.80661584
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79231524
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78737104
121SMAD3_21741376_ChIP-Seq_EPCs_Human0.78029677
122KLF5_20875108_ChIP-Seq_MESCs_Mouse0.77786588
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.77524033
124IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.77496526
125SMAD4_21799915_ChIP-Seq_A2780_Human0.77105660
126NFE2_27457419_Chip-Seq_LIVER_Mouse0.76294636
127VDR_21846776_ChIP-Seq_THP-1_Human0.75787103
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74947989
129SRF_21415370_ChIP-Seq_HL-1_Mouse0.74737039
130MYB_26560356_Chip-Seq_TH1_Human0.74110758
131NANOG_21062744_ChIP-ChIP_HESCs_Human0.73893501
132CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72902634
133FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.72342847
134NOTCH1_21737748_ChIP-Seq_TLL_Human0.71200851
135ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70734475
136SOX2_16153702_ChIP-ChIP_HESCs_Human0.67986193
137STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66721884
138NANOG_16153702_ChIP-ChIP_HESCs_Human0.62509475
139MYB_26560356_Chip-Seq_TH2_Human0.61970482
140POU5F1_16153702_ChIP-ChIP_HESCs_Human0.60821458
141SCL_19346495_ChIP-Seq_HPC-7_Human0.60263345

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.15114073
2MP0008057_abnormal_DNA_replication4.98813422
3MP0003693_abnormal_embryo_hatching4.37843830
4MP0003111_abnormal_nucleus_morphology4.22213201
5MP0003077_abnormal_cell_cycle3.79570158
6MP0008058_abnormal_DNA_repair3.50145318
7MP0004957_abnormal_blastocyst_morpholog3.46761054
8MP0008877_abnormal_DNA_methylation2.89456709
9MP0002396_abnormal_hematopoietic_system2.81876111
10MP0008007_abnormal_cellular_replicative2.73866214
11MP0010307_abnormal_tumor_latency2.40452604
12MP0008932_abnormal_embryonic_tissue2.28993678
13MP0000569_abnormal_digit_pigmentation2.25285779
14MP0003123_paternal_imprinting2.11571943
15MP0003121_genomic_imprinting2.11564943
16MP0000350_abnormal_cell_proliferation2.09257449
17MP0010352_gastrointestinal_tract_polyps2.06526660
18MP0001730_embryonic_growth_arrest1.91611107
19MP0004808_abnormal_hematopoietic_stem1.90533755
20MP0003786_premature_aging1.89240157
21MP0006072_abnormal_retinal_apoptosis1.72128536
22MP0005380_embryogenesis_phenotype1.64860874
23MP0001672_abnormal_embryogenesis/_devel1.64860874
24MP0003136_yellow_coat_color1.58073023
25MP0003890_abnormal_embryonic-extraembry1.56432745
26MP0001697_abnormal_embryo_size1.56227044
27MP0000490_abnormal_crypts_of1.50794968
28MP0003984_embryonic_growth_retardation1.48019178
29MP0004197_abnormal_fetal_growth/weight/1.46922240
30MP0002088_abnormal_embryonic_growth/wei1.43792602
31MP0002085_abnormal_embryonic_tissue1.43105885
32MP0004147_increased_porphyrin_level1.42209840
33MP0005076_abnormal_cell_differentiation1.42129764
34MP0001293_anophthalmia1.39679822
35MP0002084_abnormal_developmental_patter1.38626562
36MP0000427_abnormal_hair_cycle1.37514700
37MP0002210_abnormal_sex_determination1.37056855
38MP0003787_abnormal_imprinting1.35998658
39MP0000313_abnormal_cell_death1.33673093
40MP0002086_abnormal_extraembryonic_tissu1.33267474
41MP0002080_prenatal_lethality1.33246047
42MP0003567_abnormal_fetal_cardiomyocyte1.33167627
43MP0006292_abnormal_olfactory_placode1.31818226
44MP0000372_irregular_coat_pigmentation1.28975996
45MP0002019_abnormal_tumor_incidence1.28306412
46MP0003941_abnormal_skin_development1.26432385
47MP0003763_abnormal_thymus_physiology1.26321084
48MP0001545_abnormal_hematopoietic_system1.25953057
49MP0005397_hematopoietic_system_phenotyp1.25953057
50MP0005253_abnormal_eye_physiology1.25664915
51MP0000647_abnormal_sebaceous_gland1.24868918
52MP0006054_spinal_hemorrhage1.24516919
53MP0002638_abnormal_pupillary_reflex1.21747544
54MP0000703_abnormal_thymus_morphology1.21199410
55MP0003119_abnormal_digestive_system1.18273495
56MP0005551_abnormal_eye_electrophysiolog1.18161440
57MP0005174_abnormal_tail_pigmentation1.17210188
58MP0001929_abnormal_gametogenesis1.13872983
59MP0004133_heterotaxia1.13839959
60MP0001145_abnormal_male_reproductive1.11198808
61MP0009672_abnormal_birth_weight1.10553739
62MP0009278_abnormal_bone_marrow1.10248380
63MP0002009_preneoplasia1.08505943
64MP0000631_abnormal_neuroendocrine_gland1.08316397
65MP0010030_abnormal_orbit_morphology1.08071549
66MP0002398_abnormal_bone_marrow1.07778294
67MP0002751_abnormal_autonomic_nervous1.07650955
68MP0001529_abnormal_vocalization1.05522568
69MP0001485_abnormal_pinna_reflex1.04589492
70MP0002095_abnormal_skin_pigmentation1.03808741
71MP0002006_tumorigenesis1.03222144
72MP0000015_abnormal_ear_pigmentation1.02387809
73MP0009703_decreased_birth_body1.00322408
74MP0003806_abnormal_nucleotide_metabolis1.00022958
75MP0002166_altered_tumor_susceptibility0.98394788
76MP0000653_abnormal_sex_gland0.96737958
77MP0003315_abnormal_perineum_morphology0.94593920
78MP0009333_abnormal_splenocyte_physiolog0.94127170
79MP0003937_abnormal_limbs/digits/tail_de0.94126654
80MP0002722_abnormal_immune_system0.90979222
81MP0001346_abnormal_lacrimal_gland0.90407229
82MP0001119_abnormal_female_reproductive0.89831264
83MP0000689_abnormal_spleen_morphology0.89299584
84MP0005391_vision/eye_phenotype0.88900716
85MP0003646_muscle_fatigue0.87129343
86MP0002233_abnormal_nose_morphology0.86215358
87MP0003195_calcinosis0.82971990
88MP0003878_abnormal_ear_physiology0.82471030
89MP0005377_hearing/vestibular/ear_phenot0.82471030
90MP0002234_abnormal_pharynx_morphology0.80410242
91MP0003861_abnormal_nervous_system0.79893332
92MP0002092_abnormal_eye_morphology0.79404970
93MP0002938_white_spotting0.78181533
94MP0003943_abnormal_hepatobiliary_system0.78169409
95MP0001286_abnormal_eye_development0.77897321
96MP0010678_abnormal_skin_adnexa0.77832984
97MP0001915_intracranial_hemorrhage0.77807955
98MP0009697_abnormal_copulation0.77747255
99MP0001324_abnormal_eye_pigmentation0.76561286
100MP0002837_dystrophic_cardiac_calcinosis0.75743398
101MP0005645_abnormal_hypothalamus_physiol0.75163668
102MP0003935_abnormal_craniofacial_develop0.75158823
103MP0008789_abnormal_olfactory_epithelium0.75027314
104MP0002075_abnormal_coat/hair_pigmentati0.74962506
105MP0000432_abnormal_head_morphology0.73525509
106MP0006035_abnormal_mitochondrial_morpho0.72415263
107MP0002736_abnormal_nociception_after0.72117847
108MP0002429_abnormal_blood_cell0.71651622
109MP0005384_cellular_phenotype0.71144051
110MP0008995_early_reproductive_senescence0.70666279
111MP0005621_abnormal_cell_physiology0.70505897
112MP0002111_abnormal_tail_morphology0.70155268
113MP0005646_abnormal_pituitary_gland0.69587051
114MP0004215_abnormal_myocardial_fiber0.69233283
115MP0003115_abnormal_respiratory_system0.68736479
116MP0005195_abnormal_posterior_eye0.68414995
117MP0005389_reproductive_system_phenotype0.67534987
118MP0009046_muscle_twitch0.67003034
119MP0002160_abnormal_reproductive_system0.66380112
120MP0005075_abnormal_melanosome_morpholog0.66104561
121MP0000428_abnormal_craniofacial_morphol0.65472987
122MP0003698_abnormal_male_reproductive0.65127396
123MP0000537_abnormal_urethra_morphology0.63789431
124MP0002161_abnormal_fertility/fecundity0.63538769
125MP0001186_pigmentation_phenotype0.63499367
126MP0000716_abnormal_immune_system0.63241849
127MP0000383_abnormal_hair_follicle0.62642124
128MP0003950_abnormal_plasma_membrane0.62020749
129MP0002697_abnormal_eye_size0.61925980
130MP0005408_hypopigmentation0.61768781
131MP0002925_abnormal_cardiovascular_devel0.60443636
132MP0003705_abnormal_hypodermis_morpholog0.60003469
133MP0000733_abnormal_muscle_development0.59953358
134MP0002102_abnormal_ear_morphology0.59207078
135MP0003755_abnormal_palate_morphology0.58800927
136MP0003718_maternal_effect0.56026370
137MP0001919_abnormal_reproductive_system0.55349297
138MP0000049_abnormal_middle_ear0.55297179
139MP0001835_abnormal_antigen_presentation0.55051229

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.09547503
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.83762341
3Birth length less than 3rd percentile (HP:0003561)4.24783917
4Abnormality of chromosome stability (HP:0003220)3.85330331
5Volvulus (HP:0002580)3.84949348
6Ectopic kidney (HP:0000086)3.65063354
7Meckel diverticulum (HP:0002245)3.26902837
8Short 4th metacarpal (HP:0010044)3.21867135
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.21867135
10Abnormality of the ileum (HP:0001549)3.16233044
11Impulsivity (HP:0100710)3.14276301
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.12197517
13Abnormality of the preputium (HP:0100587)3.10478879
14Abnormality of the fingertips (HP:0001211)3.08733820
15Medulloblastoma (HP:0002885)3.07173791
16Colon cancer (HP:0003003)3.01944187
17Reticulocytopenia (HP:0001896)3.00504683
18Pancreatic cysts (HP:0001737)2.91952735
19Patellar aplasia (HP:0006443)2.89842505
20Selective tooth agenesis (HP:0001592)2.89790455
21Ependymoma (HP:0002888)2.83381047
22Agnosia (HP:0010524)2.80301831
23Myelodysplasia (HP:0002863)2.79291703
24Pancreatic fibrosis (HP:0100732)2.75503291
25Aplasia/Hypoplasia of the patella (HP:0006498)2.73889548
26Duodenal stenosis (HP:0100867)2.73721116
27Small intestinal stenosis (HP:0012848)2.73721116
28Increased nuchal translucency (HP:0010880)2.73187543
29Molar tooth sign on MRI (HP:0002419)2.71095253
30Abnormality of midbrain morphology (HP:0002418)2.71095253
31Abnormality of the labia minora (HP:0012880)2.69413457
3211 pairs of ribs (HP:0000878)2.63787929
33Nephroblastoma (Wilms tumor) (HP:0002667)2.60596596
34Abnormal number of incisors (HP:0011064)2.57138222
35Breast hypoplasia (HP:0003187)2.56506196
36True hermaphroditism (HP:0010459)2.54068128
37Long eyelashes (HP:0000527)2.51382182
38Rhabdomyosarcoma (HP:0002859)2.50626255
39Abnormal lung lobation (HP:0002101)2.48340510
40Sloping forehead (HP:0000340)2.47695286
41Duplicated collecting system (HP:0000081)2.47021743
42Abnormality of the carotid arteries (HP:0005344)2.44858357
43Embryonal renal neoplasm (HP:0011794)2.44611622
44Nephronophthisis (HP:0000090)2.44307484
45Chronic hepatic failure (HP:0100626)2.38908996
46Oral leukoplakia (HP:0002745)2.38393769
47Prominent nose (HP:0000448)2.38355825
48Bone marrow hypocellularity (HP:0005528)2.36201776
49Facial hemangioma (HP:0000329)2.29752254
50Premature graying of hair (HP:0002216)2.29005596
51Bilateral microphthalmos (HP:0007633)2.28575099
52Partial agenesis of the corpus callosum (HP:0001338)2.28231401
53Deviation of the thumb (HP:0009603)2.28083878
54Abnormality of the renal collecting system (HP:0004742)2.28036376
55Proximal placement of thumb (HP:0009623)2.27877219
56Abnormality of the duodenum (HP:0002246)2.27268556
57Absent radius (HP:0003974)2.24999612
58Abnormality of the pons (HP:0007361)2.24199872
59Clubbing of toes (HP:0100760)2.22963963
60Neoplasm of the oral cavity (HP:0100649)2.22786761
61Short thumb (HP:0009778)2.22197534
62Hypoplasia of the pons (HP:0012110)2.21069405
63Neoplasm of the adrenal cortex (HP:0100641)2.20836238
64Abnormality of the anterior horn cell (HP:0006802)2.20748452
65Degeneration of anterior horn cells (HP:0002398)2.20748452
66Aplasia/Hypoplasia of the sternum (HP:0006714)2.17344896
67Deep philtrum (HP:0002002)2.16993236
68Acute myeloid leukemia (HP:0004808)2.14346901
69Atresia of the external auditory canal (HP:0000413)2.14157471
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13607770
71Abnormality of alanine metabolism (HP:0010916)2.13607770
72Hyperalaninemia (HP:0003348)2.13607770
73High pitched voice (HP:0001620)2.12350746
74Absent thumb (HP:0009777)2.10195154
75Basal cell carcinoma (HP:0002671)2.08742334
76Glioma (HP:0009733)2.08011188
77Cafe-au-lait spot (HP:0000957)2.07929033
78Abnormality of the astrocytes (HP:0100707)2.07873026
79Astrocytoma (HP:0009592)2.07873026
80Aplasia involving forearm bones (HP:0009822)2.06442091
81Absent forearm bone (HP:0003953)2.06442091
82Abnormality of DNA repair (HP:0003254)2.04126962
83Microtia (HP:0008551)2.03445652
84Abnormality of the renal medulla (HP:0100957)2.03169511
85Abnormality of the renal cortex (HP:0011035)2.02694222
86Intestinal atresia (HP:0011100)2.02688957
87Neoplasm of the pancreas (HP:0002894)2.01013342
88Abnormality of the 4th metacarpal (HP:0010012)2.00369231
89Astigmatism (HP:0000483)2.00347571
90Cerebellar dysplasia (HP:0007033)2.00129641
91Cortical dysplasia (HP:0002539)1.99720413
92Tracheoesophageal fistula (HP:0002575)1.98888276
93Neoplasm of striated muscle (HP:0009728)1.98308974
94Acute lymphatic leukemia (HP:0006721)1.98244965
95Oligohydramnios (HP:0001562)1.93526045
96Neoplasm of the colon (HP:0100273)1.93132216
97Renal cortical cysts (HP:0000803)1.91223433
98Sclerocornea (HP:0000647)1.90127305
99Small hand (HP:0200055)1.86676017
100Lymphoma (HP:0002665)1.85276157
101Abnormality of chromosome segregation (HP:0002916)1.84762094
102Horseshoe kidney (HP:0000085)1.84596542
103Dandy-Walker malformation (HP:0001305)1.82889927
104Medial flaring of the eyebrow (HP:0010747)1.82463894
105Preaxial hand polydactyly (HP:0001177)1.81962869
106Abnormality of the columella (HP:0009929)1.81763474
107Aplasia/Hypoplasia of the tongue (HP:0010295)1.81533159
108Aplasia/Hypoplasia of the earlobes (HP:0009906)1.80676810
109Supernumerary spleens (HP:0009799)1.80429834
110Abnormal biliary tract physiology (HP:0012439)1.80079171
111Bile duct proliferation (HP:0001408)1.80079171
112Cellular immunodeficiency (HP:0005374)1.77964374
113Broad palm (HP:0001169)1.77638915
114Tubulointerstitial nephritis (HP:0001970)1.77189303
115Anencephaly (HP:0002323)1.77048294
116Triphalangeal thumb (HP:0001199)1.76603734
117Missing ribs (HP:0000921)1.75406278
118Aplastic anemia (HP:0001915)1.75366707
119Amaurosis fugax (HP:0100576)1.75341758
120Arteriovenous malformation (HP:0100026)1.74820757
121Abnormality of the incisor (HP:0000676)1.74457198
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74254438
123Abnormality of abdominal situs (HP:0011620)1.73615590
124Abdominal situs inversus (HP:0003363)1.73615590
125Trigonocephaly (HP:0000243)1.73422915
126Optic nerve coloboma (HP:0000588)1.72780276
127Embryonal neoplasm (HP:0002898)1.72443255
128Truncal obesity (HP:0001956)1.72287015
129Squamous cell carcinoma (HP:0002860)1.71954303
130Bifid tongue (HP:0010297)1.71531249
131Congenital stationary night blindness (HP:0007642)1.69447732
132Biliary tract neoplasm (HP:0100574)1.68919812
133Anal stenosis (HP:0002025)1.64663454
134Septo-optic dysplasia (HP:0100842)1.64357484
135Long clavicles (HP:0000890)1.64091547
136Carpal bone hypoplasia (HP:0001498)1.63927628
137Oligodactyly (hands) (HP:0001180)1.63765701
138Cystic liver disease (HP:0006706)1.63150082
139Sandal gap (HP:0001852)1.63098774
140Congenital primary aphakia (HP:0007707)1.62436237
141Postaxial foot polydactyly (HP:0001830)1.61606288
142Genital tract atresia (HP:0001827)1.60945217
143Gastrointestinal atresia (HP:0002589)1.60434120
144Overlapping toe (HP:0001845)1.60277668
145Supernumerary bones of the axial skeleton (HP:0009144)1.60277663
146Pancreatic islet-cell hyperplasia (HP:0004510)1.58053038
147Slender long bone (HP:0003100)1.57599193
148Vaginal atresia (HP:0000148)1.57369412
149Rib fusion (HP:0000902)1.57130378
150Attenuation of retinal blood vessels (HP:0007843)1.56232795
151Choanal atresia (HP:0000453)1.56181946
152Aganglionic megacolon (HP:0002251)1.53830623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.76577002
2WEE13.59757547
3NEK23.42291945
4SRPK13.13816403
5CDK122.96329407
6FRK2.61807318
7TTK2.53796065
8MKNK12.47326478
9EIF2AK12.46965892
10ATR2.37556088
11BRSK22.25054091
12PLK42.22747723
13BUB12.22074831
14TLK12.19910446
15TAF12.16634208
16WNK32.07551194
17MKNK22.04883465
18PLK12.04141433
19BMPR1B1.99297347
20ACVR1B1.91479109
21CHEK21.86227298
22AURKB1.85920669
23BRD41.84939963
24ZAK1.75494633
25VRK11.75439744
26PASK1.71226552
27PLK31.71111702
28TRIM281.67558295
29STK41.65742505
30CDK71.65734926
31CCNB11.63320014
32EIF2AK31.62605865
33CHEK11.56114723
34TSSK61.54458011
35CDK41.53730793
36NEK11.53325016
37MST41.50381658
38MAP4K21.46013847
39RPS6KA41.41381282
40ATM1.41303830
41BRSK11.37150241
42DYRK31.36537872
43VRK21.31382292
44RPS6KB21.30804086
45CDK81.24222915
46CDK61.22923820
47LATS11.21081126
48PNCK1.20836196
49INSRR1.18742962
50EIF2AK21.18288772
51STK101.12194661
52CLK11.10114739
53CDK21.05756968
54MAP3K81.05713140
55PIM11.01704216
56STK30.99963480
57MELK0.99611640
58TNIK0.96695688
59EEF2K0.95994939
60CDK10.93355683
61WNK40.90409565
62ADRBK20.89864167
63CAMK1D0.86135363
64MAP3K40.84903999
65AURKA0.84840881
66MAP4K10.83306480
67TEC0.80092867
68STK390.79898399
69FGFR20.78136387
70YES10.77936558
71OXSR10.77769382
72BCR0.76583624
73MAPK130.76529420
74CDK90.74527340
75GRK10.72461170
76CASK0.68986534
77CSNK1G10.67946391
78STK38L0.67306067
79TGFBR10.66147405
80RPS6KA50.62463618
81NUAK10.61541916
82TXK0.59851539
83PRKDC0.58152077
84CSNK2A20.56047787
85CSNK2A10.54961234
86CHUK0.54146558
87MTOR0.53918919
88MAPK140.52711058
89MAP3K100.52597677
90MAP3K130.52324231
91IRAK40.51531535
92MAP3K140.51129281
93BTK0.48382413
94NME10.48095832
95CSNK1G30.47712565
96CSNK1G20.47268911
97PAK40.47027368
98ERBB30.46874707
99TESK20.46849407
100CDK190.45768049
101CSNK1A1L0.43156367
102RPS6KB10.42544381
103AKT10.42484803
104SCYL20.42099892
105DYRK20.41720074
106MAPKAPK50.41642644
107NLK0.41567546
108CSNK1D0.40728136
109STK160.39490618
110MARK30.39176508
111MET0.38283430
112NME20.37627073
113PBK0.37549205
114ALK0.37423963
115MAP2K30.35820720
116GSK3B0.34398578
117CDK30.32520631
118FLT30.32460626
119ITK0.32220748
120PINK10.31628828
121TRPM70.31612935
122FGFR10.31482638
123CSF1R0.31152939
124MAPK10.30375403
125CAMK1G0.29617067
126PLK20.28825459
127NEK90.28825194
128PRKCG0.28594756
129PKN10.27374844
130ERBB40.26338244
131JAK30.25493094
132KIT0.25413876
133AKT20.24830013
134RPS6KC10.23781181
135RPS6KL10.23781181
136RPS6KA60.23502389
137CSNK1E0.21260909
138SIK30.20262039
139MAPK80.19939166

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.37606980
2Mismatch repair_Homo sapiens_hsa034304.68907264
3Homologous recombination_Homo sapiens_hsa034403.67119190
4Cell cycle_Homo sapiens_hsa041103.29696377
5Base excision repair_Homo sapiens_hsa034103.26045114
6Fanconi anemia pathway_Homo sapiens_hsa034603.18852057
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06972412
8Spliceosome_Homo sapiens_hsa030402.94392681
9One carbon pool by folate_Homo sapiens_hsa006702.86613074
10Non-homologous end-joining_Homo sapiens_hsa034502.84971751
11RNA transport_Homo sapiens_hsa030132.80596178
12Nucleotide excision repair_Homo sapiens_hsa034202.79922832
13RNA polymerase_Homo sapiens_hsa030202.08793526
14RNA degradation_Homo sapiens_hsa030182.08784337
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00545201
16mRNA surveillance pathway_Homo sapiens_hsa030151.98977108
17Systemic lupus erythematosus_Homo sapiens_hsa053221.98497870
18Pyrimidine metabolism_Homo sapiens_hsa002401.97419775
19Basal transcription factors_Homo sapiens_hsa030221.90686047
20Protein export_Homo sapiens_hsa030601.69936115
21p53 signaling pathway_Homo sapiens_hsa041151.68831342
22Ribosome_Homo sapiens_hsa030101.68732861
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54759929
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51516773
25Propanoate metabolism_Homo sapiens_hsa006401.44472886
26Proteasome_Homo sapiens_hsa030501.41994205
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36250600
28Viral carcinogenesis_Homo sapiens_hsa052031.26972805
29Phototransduction_Homo sapiens_hsa047441.26638768
30Herpes simplex infection_Homo sapiens_hsa051681.25689100
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17106336
32Oocyte meiosis_Homo sapiens_hsa041141.16110026
33Epstein-Barr virus infection_Homo sapiens_hsa051691.11674252
34MicroRNAs in cancer_Homo sapiens_hsa052061.11465454
35Purine metabolism_Homo sapiens_hsa002301.07731407
36Antigen processing and presentation_Homo sapiens_hsa046121.07626178
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05898610
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02372832
39Steroid biosynthesis_Homo sapiens_hsa001001.01106685
40HTLV-I infection_Homo sapiens_hsa051660.98620523
41Nitrogen metabolism_Homo sapiens_hsa009100.97931889
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94340661
43Alcoholism_Homo sapiens_hsa050340.92303552
44Small cell lung cancer_Homo sapiens_hsa052220.90801056
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87653128
46Butanoate metabolism_Homo sapiens_hsa006500.87450121
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85937065
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83430175
49Primary immunodeficiency_Homo sapiens_hsa053400.82629055
50Caffeine metabolism_Homo sapiens_hsa002320.79570345
51Pyruvate metabolism_Homo sapiens_hsa006200.78466814
52Huntingtons disease_Homo sapiens_hsa050160.76243994
53Lysine degradation_Homo sapiens_hsa003100.74856317
54Oxidative phosphorylation_Homo sapiens_hsa001900.73817868
55Selenocompound metabolism_Homo sapiens_hsa004500.73346683
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72466645
57Parkinsons disease_Homo sapiens_hsa050120.72114857
58Measles_Homo sapiens_hsa051620.71821701
59Hepatitis B_Homo sapiens_hsa051610.71546252
60Nicotine addiction_Homo sapiens_hsa050330.71487942
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70013739
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.69451978
63Olfactory transduction_Homo sapiens_hsa047400.68404648
64Chronic myeloid leukemia_Homo sapiens_hsa052200.65854075
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65421284
66Ether lipid metabolism_Homo sapiens_hsa005650.65351593
67Colorectal cancer_Homo sapiens_hsa052100.62295995
68Taste transduction_Homo sapiens_hsa047420.60541722
69TGF-beta signaling pathway_Homo sapiens_hsa043500.60098861
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58896763
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57437900
72Vitamin digestion and absorption_Homo sapiens_hsa049770.57138589
73Tryptophan metabolism_Homo sapiens_hsa003800.56205628
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56064470
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56040377
76Linoleic acid metabolism_Homo sapiens_hsa005910.55682840
77Notch signaling pathway_Homo sapiens_hsa043300.54677351
78Prostate cancer_Homo sapiens_hsa052150.53105416
79Thyroid cancer_Homo sapiens_hsa052160.52757534
80Influenza A_Homo sapiens_hsa051640.51738786
81Viral myocarditis_Homo sapiens_hsa054160.51643564
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.51313385
83Basal cell carcinoma_Homo sapiens_hsa052170.51089483
84Hematopoietic cell lineage_Homo sapiens_hsa046400.50517642
85Adherens junction_Homo sapiens_hsa045200.50271683
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49846394
87Legionellosis_Homo sapiens_hsa051340.47862702
88Folate biosynthesis_Homo sapiens_hsa007900.46095775
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45065402
90Pancreatic cancer_Homo sapiens_hsa052120.44859926
91Peroxisome_Homo sapiens_hsa041460.44849999
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44708472
93Metabolic pathways_Homo sapiens_hsa011000.44602689
94Vitamin B6 metabolism_Homo sapiens_hsa007500.44250267
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44223861
96Apoptosis_Homo sapiens_hsa042100.43461202
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.42180250
98Pathways in cancer_Homo sapiens_hsa052000.40443905
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40302662
100Hippo signaling pathway_Homo sapiens_hsa043900.38230906
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37235638
102Shigellosis_Homo sapiens_hsa051310.35201429
103Non-small cell lung cancer_Homo sapiens_hsa052230.34225189
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32407607
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32031871
106B cell receptor signaling pathway_Homo sapiens_hsa046620.31910000
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28913986
108Wnt signaling pathway_Homo sapiens_hsa043100.27878792
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27653224
110T cell receptor signaling pathway_Homo sapiens_hsa046600.27156552
111Fatty acid metabolism_Homo sapiens_hsa012120.27085212
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26511575
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26308892
114Glutathione metabolism_Homo sapiens_hsa004800.25794724
115FoxO signaling pathway_Homo sapiens_hsa040680.25128422
116Fatty acid elongation_Homo sapiens_hsa000620.24734992
117HIF-1 signaling pathway_Homo sapiens_hsa040660.23711086
118Graft-versus-host disease_Homo sapiens_hsa053320.23674156
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.23180569
120Acute myeloid leukemia_Homo sapiens_hsa052210.22126592
121Pentose phosphate pathway_Homo sapiens_hsa000300.22085472
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22039773
123Alzheimers disease_Homo sapiens_hsa050100.22035742
124Melanoma_Homo sapiens_hsa052180.22012202
125Leishmaniasis_Homo sapiens_hsa051400.21807235
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.21769345
127Hedgehog signaling pathway_Homo sapiens_hsa043400.21380826
128N-Glycan biosynthesis_Homo sapiens_hsa005100.21359677
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19518221
130Allograft rejection_Homo sapiens_hsa053300.19447308
131Asthma_Homo sapiens_hsa053100.19409951
132mTOR signaling pathway_Homo sapiens_hsa041500.18942798
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.18300936
134Proteoglycans in cancer_Homo sapiens_hsa052050.18267212
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18189295
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17578158
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.17250356
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16338783
139Regulation of autophagy_Homo sapiens_hsa041400.16226909
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.15514403
141Fatty acid biosynthesis_Homo sapiens_hsa000610.14616801
142Platelet activation_Homo sapiens_hsa046110.14445658
143Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14300249
144Toxoplasmosis_Homo sapiens_hsa051450.13599423
145Bladder cancer_Homo sapiens_hsa052190.13578144
146Serotonergic synapse_Homo sapiens_hsa047260.12550833
147Morphine addiction_Homo sapiens_hsa050320.12258158
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.12228692
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.11955719
150Retinol metabolism_Homo sapiens_hsa008300.08174436
151GABAergic synapse_Homo sapiens_hsa047270.07854568
152Fatty acid degradation_Homo sapiens_hsa000710.07750377
153Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.07570130

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