ZHX1-C8ORF76

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring zinc fingers and homeoboxes 1 (ZHX1) and chromosome 8 open reading frame 76 (C8orf76) genes. The read-through transcript encodes a protein that shares sequence identity with the downstream gene, but it has a distinct N-terminus encoded by exon structure from the upstream gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein prenylation (GO:0018342)9.04305820
2prenylation (GO:0097354)9.04305820
3positive regulation of mitotic sister chromatid separation (GO:1901970)8.82215843
4positive regulation of mitotic metaphase/anaphase transition (GO:0045842)8.82215843
5positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)8.82215843
6regulation of sister chromatid cohesion (GO:0007063)6.87009214
7negative regulation of Ras GTPase activity (GO:0034261)6.74154182
8eosinophil chemotaxis (GO:0048245)6.56439821
9negative regulation of T cell receptor signaling pathway (GO:0050860)6.31388113
10ribosomal small subunit assembly (GO:0000028)6.18648397
11positive regulation of chromosome segregation (GO:0051984)6.04215340
12eosinophil migration (GO:0072677)5.92202061
13vesicle fusion (GO:0006906)5.39607364
14regulation of mononuclear cell migration (GO:0071675)5.24318502
15proteasome assembly (GO:0043248)4.95889507
16organelle membrane fusion (GO:0090174)4.87654851
17negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.84456031
18L-fucose catabolic process (GO:0042355)4.71634551
19fucose catabolic process (GO:0019317)4.71634551
20L-fucose metabolic process (GO:0042354)4.71634551
21autophagic vacuole fusion (GO:0000046)4.65116421
22coenzyme A biosynthetic process (GO:0015937)4.59262710
23negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.56839047
24peptidyl-lysine dimethylation (GO:0018027)4.48191315
25localization within membrane (GO:0051668)4.46409219
26double-strand break repair via nonhomologous end joining (GO:0006303)4.28732602
27non-recombinational repair (GO:0000726)4.28732602
28metallo-sulfur cluster assembly (GO:0031163)4.24271435
29iron-sulfur cluster assembly (GO:0016226)4.24271435
30negative regulation of circadian rhythm (GO:0042754)4.17741658
31regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.08591884
32branch elongation of an epithelium (GO:0060602)3.89895514
33telomere maintenance via recombination (GO:0000722)3.83998682
34organ growth (GO:0035265)3.83105888
35positive regulation of calcium ion import (GO:0090280)3.81140333
36negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.72253894
37seminiferous tubule development (GO:0072520)3.71379329
38mitochondrial RNA metabolic process (GO:0000959)3.67744929
39membrane budding (GO:0006900)3.66516985
40organelle fusion (GO:0048284)3.62331367
41regulation of autophagic vacuole assembly (GO:2000785)3.61822506
42regulation of T cell receptor signaling pathway (GO:0050856)3.59579299
43preassembly of GPI anchor in ER membrane (GO:0016254)3.58167438
44regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.57822471
45protein import into peroxisome matrix (GO:0016558)3.57705269
46histone H3-K9 methylation (GO:0051567)3.57218624
47protein sumoylation (GO:0016925)3.53938495
483-UTR-mediated mRNA stabilization (GO:0070935)3.52712194
49macrophage chemotaxis (GO:0048246)3.52429964
50pteridine-containing compound biosynthetic process (GO:0042559)3.48242935
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.46185004
52termination of RNA polymerase III transcription (GO:0006386)3.46185004
53mitotic recombination (GO:0006312)3.38440683
54Golgi transport vesicle coating (GO:0048200)3.30293633
55COPI coating of Golgi vesicle (GO:0048205)3.30293633
56purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.28618534
57ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.28618534
58nucleoside bisphosphate biosynthetic process (GO:0033866)3.28618534
59histone H3-K9 modification (GO:0061647)3.27036024
60fucose metabolic process (GO:0006004)3.20930692
61negative regulation of GTP catabolic process (GO:0033125)3.20165489
62negative regulation of GTPase activity (GO:0034260)3.20165489
63RNA methylation (GO:0001510)3.19615264
64coenzyme A metabolic process (GO:0015936)3.19274757
65folic acid-containing compound biosynthetic process (GO:0009396)3.18356289
66oxidative demethylation (GO:0070989)3.18062903
67regulation of beta-amyloid formation (GO:1902003)3.16599825
68detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.16028432
69regulation of vacuole organization (GO:0044088)3.14396152
70monocyte chemotaxis (GO:0002548)3.12591265
71protein-chromophore linkage (GO:0018298)3.11343267
72single-organism membrane fusion (GO:0044801)3.08951400
73COPII vesicle coating (GO:0048208)3.07044944
74transcription-coupled nucleotide-excision repair (GO:0006283)3.03143523
75detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.00382055
76establishment of mitotic spindle orientation (GO:0000132)2.99917889
77protein K6-linked ubiquitination (GO:0085020)2.99693091
78intracellular protein transmembrane import (GO:0044743)2.97054156
79ER to Golgi vesicle-mediated transport (GO:0006888)2.94943004
80pseudouridine synthesis (GO:0001522)2.92929722
817-methylguanosine mRNA capping (GO:0006370)2.90221364
82establishment of mitotic spindle localization (GO:0040001)2.85274352
837-methylguanosine RNA capping (GO:0009452)2.82396219
84RNA capping (GO:0036260)2.82396219
85protein complex biogenesis (GO:0070271)2.81172592
86acrosome assembly (GO:0001675)2.80796439
87mitochondrial respiratory chain complex assembly (GO:0033108)2.76705185
88pantothenate metabolic process (GO:0015939)2.73985768
89regulation of chronic inflammatory response (GO:0002676)2.71650169
90DNA integration (GO:0015074)2.64130330
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.63909986
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.63909986
93DNA demethylation (GO:0080111)2.63131038
94C-terminal protein lipidation (GO:0006501)2.62669111
95positive chemotaxis (GO:0050918)2.58265262
96RNA modification (GO:0009451)2.57736975
97pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.57666250
98GPI anchor biosynthetic process (GO:0006506)2.57446092
99establishment of protein localization to mitochondrial membrane (GO:0090151)2.57249782
100cardiolipin metabolic process (GO:0032048)2.57208089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.15017185
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.90916655
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.11546079
4NOTCH1_21737748_ChIP-Seq_TLL_Human3.88212395
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.71184095
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.55386806
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.45401767
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.40468023
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.28084631
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.90347821
11SRF_21415370_ChIP-Seq_HL-1_Mouse2.75626541
12VDR_23849224_ChIP-Seq_CD4+_Human2.68908406
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68858217
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.67041482
15E2F7_22180533_ChIP-Seq_HELA_Human2.66179333
16VDR_22108803_ChIP-Seq_LS180_Human2.58855981
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48797835
18YY1_21170310_ChIP-Seq_MESCs_Mouse2.42827628
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.40385872
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32355512
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.27634457
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27633653
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10785444
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10565315
25ELK1_19687146_ChIP-ChIP_HELA_Human2.08744315
26FOXP3_21729870_ChIP-Seq_TREG_Human2.08288131
27DCP1A_22483619_ChIP-Seq_HELA_Human2.05891480
28ZNF263_19887448_ChIP-Seq_K562_Human1.99921509
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96208662
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90515352
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88289653
32GABP_19822575_ChIP-Seq_HepG2_Human1.87784558
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75683339
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.74966736
35TFEB_21752829_ChIP-Seq_HELA_Human1.71031394
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62818636
37TTF2_22483619_ChIP-Seq_HELA_Human1.57841611
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54880731
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54491753
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54292337
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.53535671
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51181710
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50160966
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49410555
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49296225
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49261395
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48904517
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46109663
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41093042
50ZNF274_21170338_ChIP-Seq_K562_Hela1.39420474
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36681594
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35990428
53PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.35675369
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33293244
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31006282
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30257954
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28102122
58GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23608288
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22515120
60KDM5A_27292631_Chip-Seq_BREAST_Human1.20891987
61TAF15_26573619_Chip-Seq_HEK293_Human1.15349862
62HTT_18923047_ChIP-ChIP_STHdh_Human1.13942596
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13361010
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12796000
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.06888699
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05228647
67XRN2_22483619_ChIP-Seq_HELA_Human1.03706512
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02695588
69CIITA_25753668_ChIP-Seq_RAJI_Human1.02315477
70SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98955955
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96856337
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96052624
73GATA3_26560356_Chip-Seq_TH1_Human0.95665257
74MYC_18940864_ChIP-ChIP_HL60_Human0.94644577
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93747557
76MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93422398
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93353769
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93106968
79TP53_22573176_ChIP-Seq_HFKS_Human0.90842025
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90371422
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90096182
82IRF1_19129219_ChIP-ChIP_H3396_Human0.89730538
83ZFX_18555785_ChIP-Seq_MESCs_Mouse0.82078556
84SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81683929
85E2F1_21310950_ChIP-Seq_MCF-7_Human0.80974957
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79987888
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77268663
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.77141067
89SPI1_23547873_ChIP-Seq_NB4_Human0.75345422
90STAT4_19710469_ChIP-ChIP_TH1__Mouse0.73160671
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72885445
92FUS_26573619_Chip-Seq_HEK293_Human0.70805877
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.69475512
94FOXA1_27270436_Chip-Seq_PROSTATE_Human0.69475512
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.69434652
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68553203
97TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.67315567
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.67285765
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.65339869
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.64156935

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.73436856
2MP0003303_peritoneal_inflammation6.05333663
3MP0006082_CNS_inflammation4.00638538
4MP0002638_abnormal_pupillary_reflex3.54674396
5MP0003806_abnormal_nucleotide_metabolis3.11045237
6MP0008058_abnormal_DNA_repair2.89305821
7MP0001764_abnormal_homeostasis2.85149920
8MP0002837_dystrophic_cardiac_calcinosis2.77689948
9MP0008057_abnormal_DNA_replication2.56098549
10MP0008995_early_reproductive_senescence2.35400225
11MP0001664_abnormal_digestion2.18159262
12MP0000372_irregular_coat_pigmentation2.17706392
13MP0001919_abnormal_reproductive_system2.13191895
14MP0002254_reproductive_system_inflammat2.07834694
15MP0001663_abnormal_digestive_system2.02624254
16MP0000358_abnormal_cell_content/2.01475805
17MP0008004_abnormal_stomach_pH2.01348095
18MP0008877_abnormal_DNA_methylation1.92745595
19MP0006036_abnormal_mitochondrial_physio1.76715888
20MP0003786_premature_aging1.72450696
21MP0005389_reproductive_system_phenotype1.60735801
22MP0010094_abnormal_chromosome_stability1.60718700
23MP0003195_calcinosis1.57441763
24MP0003646_muscle_fatigue1.56547464
25MP0003077_abnormal_cell_cycle1.56018861
26MP0002751_abnormal_autonomic_nervous1.52662231
27MP0000467_abnormal_esophagus_morphology1.52153716
28MP0006035_abnormal_mitochondrial_morpho1.49539320
29MP0005381_digestive/alimentary_phenotyp1.47055810
30MP0002139_abnormal_hepatobiliary_system1.45950106
31MP0005253_abnormal_eye_physiology1.40764605
32MP0003186_abnormal_redox_activity1.38117809
33MP0002019_abnormal_tumor_incidence1.37917411
34MP0001986_abnormal_taste_sensitivity1.37003600
35MP0002876_abnormal_thyroid_physiology1.34741038
36MP0003111_abnormal_nucleus_morphology1.31086130
37MP0009697_abnormal_copulation1.25599445
38MP0005379_endocrine/exocrine_gland_phen1.22988732
39MP0001661_extended_life_span1.15963130
40MP0005166_decreased_susceptibility_to1.11798708
41MP0008875_abnormal_xenobiotic_pharmacok1.10979638
42MP0002210_abnormal_sex_determination1.08743748
43MP0008932_abnormal_embryonic_tissue1.08059612
44MP0003950_abnormal_plasma_membrane1.06579366
45MP0000383_abnormal_hair_follicle1.02742433
46MP0005075_abnormal_melanosome_morpholog1.02226463
47MP0003115_abnormal_respiratory_system1.01341481
48MP0002693_abnormal_pancreas_physiology1.01144714
49MP0001929_abnormal_gametogenesis1.00275456
50MP0005397_hematopoietic_system_phenotyp0.99375421
51MP0001545_abnormal_hematopoietic_system0.99375421
52MP0002163_abnormal_gland_morphology0.95285006
53MP0005410_abnormal_fertilization0.95127815
54MP0003718_maternal_effect0.93355933
55MP0005367_renal/urinary_system_phenotyp0.91589731
56MP0000516_abnormal_urinary_system0.91589731
57MP0010678_abnormal_skin_adnexa0.91137090
58MP0003221_abnormal_cardiomyocyte_apopto0.90299786
59MP0005535_abnormal_body_temperature0.89816667
60MP0001835_abnormal_antigen_presentation0.88455219
61MP0003937_abnormal_limbs/digits/tail_de0.87836275
62MP0000343_altered_response_to0.87811210
63MP0001944_abnormal_pancreas_morphology0.85987932
64MP0004957_abnormal_blastocyst_morpholog0.85090358
65MP0009785_altered_susceptibility_to0.83118201
66MP0003656_abnormal_erythrocyte_physiolo0.82013707
67MP0002822_catalepsy0.81837631
68MP0009763_increased_sensitivity_to0.81319203
69MP0005646_abnormal_pituitary_gland0.80217510
70MP0000653_abnormal_sex_gland0.79634726
71MP0006072_abnormal_retinal_apoptosis0.79385070
72MP0000313_abnormal_cell_death0.78185348
73MP0001145_abnormal_male_reproductive0.76256657
74MP0005220_abnormal_exocrine_pancreas0.76056097
75MP0005332_abnormal_amino_acid0.74354094
76MP0002405_respiratory_system_inflammati0.72561315
77MP0000639_abnormal_adrenal_gland0.72159054
78MP0005645_abnormal_hypothalamus_physiol0.71868103
79MP0009333_abnormal_splenocyte_physiolog0.71583497
80MP0003453_abnormal_keratinocyte_physiol0.70499736
81MP0001529_abnormal_vocalization0.70377923
82MP0000013_abnormal_adipose_tissue0.70165724
83MP0000689_abnormal_spleen_morphology0.69373814
84MP0001905_abnormal_dopamine_level0.68025045
85MP0005266_abnormal_metabolism0.67828982
86MP0002909_abnormal_adrenal_gland0.67759859
87MP0005501_abnormal_skin_physiology0.67610192
88MP0003693_abnormal_embryo_hatching0.65814387
89MP0008007_abnormal_cellular_replicative0.65291410
90MP0000350_abnormal_cell_proliferation0.65231072
91MP0005376_homeostasis/metabolism_phenot0.64328134
92MP0003763_abnormal_thymus_physiology0.63648720
93MP0002148_abnormal_hypersensitivity_rea0.61916550
94MP0002398_abnormal_bone_marrow0.61716000
95MP0004142_abnormal_muscle_tone0.61405353
96MP0004215_abnormal_myocardial_fiber0.61167331
97MP0005464_abnormal_platelet_physiology0.58898589
98MP0005408_hypopigmentation0.58305696
99MP0002078_abnormal_glucose_homeostasis0.57100368
100MP0003698_abnormal_male_reproductive0.56143846

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of long-chain fatty-acid metabolism (HP:0010964)6.73025278
2Duplicated collecting system (HP:0000081)5.92214101
3Abnormality of the renal collecting system (HP:0004742)5.48593039
4Long foot (HP:0001833)4.61989895
5Hypoplastic pelvis (HP:0008839)4.55935557
6Acute necrotizing encephalopathy (HP:0006965)4.48720229
7Large for gestational age (HP:0001520)4.38970596
8Dry hair (HP:0011359)4.38520196
9Acute lymphatic leukemia (HP:0006721)4.26543890
10Abnormal mitochondria in muscle tissue (HP:0008316)4.14733717
11Abnormality of fatty-acid metabolism (HP:0004359)4.04348737
12Progressive muscle weakness (HP:0003323)4.03384652
13Progressive macrocephaly (HP:0004481)4.01205223
14Menstrual irregularities (HP:0000858)3.99255530
15Acute encephalopathy (HP:0006846)3.87323014
163-Methylglutaconic aciduria (HP:0003535)3.84810298
17Ureteral duplication (HP:0000073)3.69859382
18Transposition of the great arteries (HP:0001669)3.45752637
19Abnormal connection of the cardiac segments (HP:0011545)3.45752637
20Abnormal ventriculo-arterial connection (HP:0011563)3.45752637
21Anhidrosis (HP:0000970)3.37699541
22Mitochondrial inheritance (HP:0001427)3.31402511
23Brushfield spots (HP:0001088)3.23926827
24Increased CSF lactate (HP:0002490)3.20817874
25Reduced subcutaneous adipose tissue (HP:0003758)3.19921875
26Autoamputation (HP:0001218)3.13249829
27Lactic acidosis (HP:0003128)3.12335587
28Adactyly (HP:0009776)3.10838378
29Steatorrhea (HP:0002570)3.05859962
30Renal Fanconi syndrome (HP:0001994)2.81732758
31Respiratory failure (HP:0002878)2.80090738
32Cerebral edema (HP:0002181)2.78173068
33Pulmonary artery stenosis (HP:0004415)2.75926957
34Ureteral stenosis (HP:0000071)2.74515240
35Increased serum lactate (HP:0002151)2.71735985
36Exercise intolerance (HP:0003546)2.58662302
37Epiphyseal stippling (HP:0010655)2.57195881
38Severe muscular hypotonia (HP:0006829)2.55528209
39Ureteral obstruction (HP:0006000)2.53753551
40Increased hepatocellular lipid droplets (HP:0006565)2.53368292
41Abnormality of aromatic amino acid family metabolism (HP:0004338)2.52865012
42Polyneuropathy (HP:0001271)2.52469207
43Hepatocellular necrosis (HP:0001404)2.50926169
44Abnormal auditory evoked potentials (HP:0006958)2.49528299
45Hepatic necrosis (HP:0002605)2.42338330
46Clubbing of toes (HP:0100760)2.41885364
47Abnormal rod and cone electroretinograms (HP:0008323)2.37461377
48Septate vagina (HP:0001153)2.34229900
49Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21043788
50Lipid accumulation in hepatocytes (HP:0006561)2.19813303
51Fat malabsorption (HP:0002630)2.19180267
52Female pseudohermaphroditism (HP:0010458)2.18007012
53Abnormality of vision evoked potentials (HP:0000649)2.17281095
54Hypoplastic nipples (HP:0002557)2.16301654
55Polymicrogyria (HP:0002126)2.07384033
56Rhabdomyolysis (HP:0003201)2.07184271
57Generalized aminoaciduria (HP:0002909)2.06548558
58Testicular neoplasm (HP:0010788)2.00223730
59Increased number of teeth (HP:0011069)1.96109713
60Abnormal epiphyseal ossification (HP:0010656)1.92951074
61Decreased activity of mitochondrial respiratory chain (HP:0008972)1.92380949
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.92380949
63Ketoacidosis (HP:0001993)1.91567097
64Decreased lacrimation (HP:0000633)1.89329047
65Basal ganglia calcification (HP:0002135)1.88550447
66Abnormality of renal resorption (HP:0011038)1.86828852
67Optic disc pallor (HP:0000543)1.86291117
68Degeneration of anterior horn cells (HP:0002398)1.86056650
69Abnormality of the anterior horn cell (HP:0006802)1.86056650
70Hypoglycemic seizures (HP:0002173)1.82936797
71Primary adrenal insufficiency (HP:0008207)1.82867737
72Multiple enchondromatosis (HP:0005701)1.82709436
73CNS demyelination (HP:0007305)1.81821492
74Metabolic acidosis (HP:0001942)1.77527716
75Exertional dyspnea (HP:0002875)1.75268038
76Sudden death (HP:0001699)1.72825258
77Purpura (HP:0000979)1.72350025
78Petechiae (HP:0000967)1.71333174
79Hypoglycemic coma (HP:0001325)1.71139689
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.70566621
81Palmoplantar hyperkeratosis (HP:0000972)1.68732718
82Broad-based gait (HP:0002136)1.67070776
83Methylmalonic acidemia (HP:0002912)1.65898295
84Increased intramyocellular lipid droplets (HP:0012240)1.64805785
85Male infertility (HP:0003251)1.62968619
86Glycosuria (HP:0003076)1.62918632
87Abnormality of urine glucose concentration (HP:0011016)1.62918632
88Large hands (HP:0001176)1.62090571
89Constricted visual fields (HP:0001133)1.60967241
90Palmar hyperkeratosis (HP:0010765)1.60669503
91Flat face (HP:0012368)1.59050264
92Lethargy (HP:0001254)1.57929299
93Tongue fasciculations (HP:0001308)1.56771139
94Symptomatic seizures (HP:0011145)1.55673921
95Type I transferrin isoform profile (HP:0003642)1.55283494
96Hyperammonemia (HP:0001987)1.55205135
97Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.53631761
98Short 1st metacarpal (HP:0010034)1.53631761
99Gonadal dysgenesis (HP:0000133)1.52044160
100Limb hypertonia (HP:0002509)1.50091210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK29.78091030
2MKNK15.82642936
3TAOK25.12810272
4TAOK14.75113132
5MAP2K34.68603056
6MAP3K113.26712151
7MAP3K33.22309808
8SRPK12.42426919
9JAK32.25297912
10ABL21.95524066
11MAP3K51.90333377
12EIF2AK11.27573888
13DYRK1A1.20484774
14BCKDK1.18458677
15MST41.18424401
16MAP3K61.17186721
17FRK1.08969674
18CHEK21.05328457
19BUB11.04990928
20TRIM280.96661129
21SIK30.92892544
22EIF2AK30.88630799
23MAP2K60.86918565
24WNK30.83762452
25CSNK1G30.79664095
26NME20.76862026
27TSSK60.74799274
28STK160.72189629
29PINK10.68114084
30MAP3K80.68107975
31CSNK1G10.67806722
32MAP3K10.60178827
33PASK0.59498293
34CDC70.59478725
35PLK30.58800210
36ZAK0.58493033
37IRAK30.55248437
38NEK10.53489250
39CSNK1G20.53055142
40ERBB30.52721920
41PLK10.49602807
42PBK0.49231164
43PDK20.48308254
44BMPR20.45971494
45ACVR1B0.43666827
46TEC0.42813383
47MARK30.42211875
48ATR0.41243370
49PLK40.39936102
50TTK0.38935051
51IKBKB0.38527881
52AURKA0.38400625
53PRKCQ0.37723585
54CSNK1A1L0.37571678
55KIT0.34727850
56MAP3K140.34675318
57CSNK2A20.34253683
58TNK20.34086902
59CSNK1A10.33363977
60MAP2K40.33318680
61TLK10.32536362
62CSNK2A10.28830786
63EIF2AK20.28028181
64VRK10.27639729
65MAPKAPK30.24091870
66NUAK10.23986152
67CCNB10.23716130
68IKBKE0.22893166
69SIK20.20971609
70ZAP700.20438055
71ADRBK20.20228263
72AURKB0.19730168
73WEE10.18907957
74PIM20.18776653
75CSNK1E0.17857205
76TBK10.17741643
77GRK10.17444340
78MAPKAPK50.16365784
79VRK20.16174526
80PRKCI0.14762221
81IRAK10.14243859
82IRAK20.14193334
83SCYL20.13881020
84GRK70.13621778
85MAP4K20.13444326
86SIK10.13089331
87ATM0.12751893
88ABL10.12279203
89CHUK0.12170607
90BMPR1B0.11445196
91STK240.10438131
92PRKAA10.09773425
93TYK20.09174682
94CHEK10.08217254
95TRPM70.08208821
96ALK0.06420367
97PRKCB0.06317086
98MAP3K40.05584069
99CDK10.04964611
100CDK70.04942629

Predicted pathways (KEGG)

RankGene SetZ-score
1SNARE interactions in vesicular transport_Homo sapiens_hsa041304.33928160
2Proteasome_Homo sapiens_hsa030503.63941649
3RNA polymerase_Homo sapiens_hsa030203.61563598
4Pantothenate and CoA biosynthesis_Homo sapiens_hsa007703.47570364
5Fatty acid elongation_Homo sapiens_hsa000623.16767060
6Protein export_Homo sapiens_hsa030602.84222865
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.78646840
8Oxidative phosphorylation_Homo sapiens_hsa001902.42849173
9One carbon pool by folate_Homo sapiens_hsa006702.31573370
10Mismatch repair_Homo sapiens_hsa034302.29065516
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.22186853
12Nucleotide excision repair_Homo sapiens_hsa034202.07496644
13DNA replication_Homo sapiens_hsa030302.05444445
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03992897
15Base excision repair_Homo sapiens_hsa034101.95789659
16RNA transport_Homo sapiens_hsa030131.93041543
17Ribosome_Homo sapiens_hsa030101.88948372
18Parkinsons disease_Homo sapiens_hsa050121.88294735
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.87310482
20Folate biosynthesis_Homo sapiens_hsa007901.73696606
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72529146
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64790267
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63086020
24Butanoate metabolism_Homo sapiens_hsa006501.61234071
25Pyrimidine metabolism_Homo sapiens_hsa002401.60099106
26Homologous recombination_Homo sapiens_hsa034401.57270672
27Propanoate metabolism_Homo sapiens_hsa006401.56230922
28Huntingtons disease_Homo sapiens_hsa050161.55374230
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40078359
30Fanconi anemia pathway_Homo sapiens_hsa034601.32645641
31Basal transcription factors_Homo sapiens_hsa030221.30734652
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29382540
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20649382
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19458292
35Taste transduction_Homo sapiens_hsa047421.17828830
36Peroxisome_Homo sapiens_hsa041461.17389520
37Steroid biosynthesis_Homo sapiens_hsa001001.17264366
38Regulation of autophagy_Homo sapiens_hsa041401.15728366
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10579112
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08805455
41Purine metabolism_Homo sapiens_hsa002301.07447677
42RNA degradation_Homo sapiens_hsa030181.06686861
43Type I diabetes mellitus_Homo sapiens_hsa049401.00876972
44Caffeine metabolism_Homo sapiens_hsa002320.93903593
45Lysine degradation_Homo sapiens_hsa003100.92614217
46Glutathione metabolism_Homo sapiens_hsa004800.89754156
47Spliceosome_Homo sapiens_hsa030400.84602952
48Alzheimers disease_Homo sapiens_hsa050100.83559480
49Epstein-Barr virus infection_Homo sapiens_hsa051690.82874683
50Collecting duct acid secretion_Homo sapiens_hsa049660.81911985
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81243290
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73236712
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70268705
54Tryptophan metabolism_Homo sapiens_hsa003800.69384503
55Asthma_Homo sapiens_hsa053100.68638893
56Non-homologous end-joining_Homo sapiens_hsa034500.66362490
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64057439
58Metabolic pathways_Homo sapiens_hsa011000.63562579
59Sulfur metabolism_Homo sapiens_hsa009200.63052387
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.62968517
61Fatty acid metabolism_Homo sapiens_hsa012120.60889487
62Glycerolipid metabolism_Homo sapiens_hsa005610.60522441
63Primary immunodeficiency_Homo sapiens_hsa053400.58998536
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.58266246
65Legionellosis_Homo sapiens_hsa051340.57457691
66Cell cycle_Homo sapiens_hsa041100.56634290
67beta-Alanine metabolism_Homo sapiens_hsa004100.55612482
68mRNA surveillance pathway_Homo sapiens_hsa030150.53738152
69Circadian rhythm_Homo sapiens_hsa047100.53279598
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52807351
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45592009
72Rheumatoid arthritis_Homo sapiens_hsa053230.44873982
73Systemic lupus erythematosus_Homo sapiens_hsa053220.44281673
74Pyruvate metabolism_Homo sapiens_hsa006200.42333244
75Cardiac muscle contraction_Homo sapiens_hsa042600.41534794
76Oocyte meiosis_Homo sapiens_hsa041140.39018909
77Herpes simplex infection_Homo sapiens_hsa051680.38753763
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38494520
79p53 signaling pathway_Homo sapiens_hsa041150.38366822
80Galactose metabolism_Homo sapiens_hsa000520.36976168
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35960888
82Olfactory transduction_Homo sapiens_hsa047400.34947669
83Carbon metabolism_Homo sapiens_hsa012000.32625531
84Hematopoietic cell lineage_Homo sapiens_hsa046400.31931149
85Phototransduction_Homo sapiens_hsa047440.31741117
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.31311716
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.30224640
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29834915
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.29388989
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.25111625
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25061530
92Allograft rejection_Homo sapiens_hsa053300.22037904
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.21778370
94Autoimmune thyroid disease_Homo sapiens_hsa053200.20938984
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.19688134
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18995118
97Selenocompound metabolism_Homo sapiens_hsa004500.17407808
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16059629
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15646999
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15037193

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