ZHX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.70653248
2L-phenylalanine catabolic process (GO:0006559)4.70653248
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.32607644
4L-phenylalanine metabolic process (GO:0006558)4.32607644
5synaptic vesicle docking involved in exocytosis (GO:0016081)4.23389438
6alpha-linolenic acid metabolic process (GO:0036109)4.21953811
7cellular ketone body metabolic process (GO:0046950)4.21686860
8aromatic amino acid family catabolic process (GO:0009074)4.21454968
9cysteine metabolic process (GO:0006534)3.82871681
10tryptophan catabolic process (GO:0006569)3.80160294
11indole-containing compound catabolic process (GO:0042436)3.80160294
12indolalkylamine catabolic process (GO:0046218)3.80160294
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.79136628
14bile acid biosynthetic process (GO:0006699)3.77102120
15cellular potassium ion homeostasis (GO:0030007)3.70032808
16urea cycle (GO:0000050)3.68643079
17urea metabolic process (GO:0019627)3.68643079
18kynurenine metabolic process (GO:0070189)3.66131552
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.62618155
20ketone body metabolic process (GO:1902224)3.61978691
21tryptophan metabolic process (GO:0006568)3.60214315
22glutamate metabolic process (GO:0006536)3.52354576
23high-density lipoprotein particle remodeling (GO:0034375)3.46646427
24sodium ion export (GO:0071436)3.45428934
25dicarboxylic acid biosynthetic process (GO:0043650)3.44471058
26homocysteine metabolic process (GO:0050667)3.43406848
27lysine catabolic process (GO:0006554)3.41788401
28lysine metabolic process (GO:0006553)3.41788401
29complement activation, alternative pathway (GO:0006957)3.37955515
30glyoxylate metabolic process (GO:0046487)3.37644455
31regulation of protein activation cascade (GO:2000257)3.36715183
32nitrogen cycle metabolic process (GO:0071941)3.33056060
33cellular modified amino acid catabolic process (GO:0042219)3.31860161
34reverse cholesterol transport (GO:0043691)3.31410263
35sulfur amino acid catabolic process (GO:0000098)3.30891326
36positive regulation of fatty acid beta-oxidation (GO:0032000)3.27843087
37serine family amino acid catabolic process (GO:0009071)3.26631413
38glutamate secretion (GO:0014047)3.22887739
39bile acid metabolic process (GO:0008206)3.21520041
40regulation of bile acid biosynthetic process (GO:0070857)3.18622680
41regulation of complement activation (GO:0030449)3.16745820
42amino-acid betaine metabolic process (GO:0006577)3.14768327
43alpha-amino acid catabolic process (GO:1901606)3.12168791
44positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.10575637
45negative regulation of fibrinolysis (GO:0051918)3.10146458
46plasma lipoprotein particle remodeling (GO:0034369)3.08136801
47protein-lipid complex remodeling (GO:0034368)3.08136801
48macromolecular complex remodeling (GO:0034367)3.08136801
49regulation of fibrinolysis (GO:0051917)3.07960253
50regulation of triglyceride catabolic process (GO:0010896)3.05518713
51protein carboxylation (GO:0018214)3.05246812
52peptidyl-glutamic acid carboxylation (GO:0017187)3.05246812
53triglyceride homeostasis (GO:0070328)3.02510297
54acylglycerol homeostasis (GO:0055090)3.02510297
55tyrosine metabolic process (GO:0006570)2.99517805
56coenzyme catabolic process (GO:0009109)2.95439020
57cellular amino acid catabolic process (GO:0009063)2.95354543
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.93858176
59regulation of short-term neuronal synaptic plasticity (GO:0048172)2.93503839
60L-amino acid import (GO:0043092)2.92060914
61gamma-aminobutyric acid transport (GO:0015812)2.91406590
62aromatic amino acid family metabolic process (GO:0009072)2.91172679
63positive regulation of fatty acid oxidation (GO:0046321)2.90533778
64cytoskeletal anchoring at plasma membrane (GO:0007016)2.88097599
65short-chain fatty acid metabolic process (GO:0046459)2.87232465
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.86359281
67amino acid import (GO:0043090)2.85446955
68pyrimidine nucleobase catabolic process (GO:0006208)2.84195711
69postsynaptic membrane organization (GO:0001941)2.82138090
70phospholipid homeostasis (GO:0055091)2.80848992
71regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.76454014
72negative regulation of protein activation cascade (GO:2000258)2.74897378
73neurotransmitter-gated ion channel clustering (GO:0072578)2.74548674
74aspartate family amino acid catabolic process (GO:0009068)2.74275093
75linoleic acid metabolic process (GO:0043651)2.72262123
76regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.72185177
77positive regulation of lipid catabolic process (GO:0050996)2.72169154
78regulation of fatty acid beta-oxidation (GO:0031998)2.71780172
79cholesterol efflux (GO:0033344)2.69977602
80drug catabolic process (GO:0042737)2.69761301
81regulation of acrosome reaction (GO:0060046)2.68988852
82dicarboxylic acid catabolic process (GO:0043649)2.68554775
83synaptic vesicle maturation (GO:0016188)2.65731520
84negative regulation of lipase activity (GO:0060192)2.64902283
85regulation of cholesterol esterification (GO:0010872)2.64687381
86phospholipid efflux (GO:0033700)2.64262414
87fatty acid transmembrane transport (GO:1902001)2.63987764
88indolalkylamine metabolic process (GO:0006586)2.63902019
89myelination in peripheral nervous system (GO:0022011)2.62476173
90peripheral nervous system axon ensheathment (GO:0032292)2.62476173
91low-density lipoprotein particle remodeling (GO:0034374)2.61927816
92cerebellar granule cell differentiation (GO:0021707)2.61261808
93regulation of cholesterol homeostasis (GO:2000188)2.60527797
94cellular sodium ion homeostasis (GO:0006883)2.59831778
95fatty acid beta-oxidation (GO:0006635)2.58561345
96bile acid and bile salt transport (GO:0015721)2.57816235
972-oxoglutarate metabolic process (GO:0006103)2.56053325
98organic acid catabolic process (GO:0016054)2.55591054
99carboxylic acid catabolic process (GO:0046395)2.55591054
100very long-chain fatty acid metabolic process (GO:0000038)2.53718206
101cellular biogenic amine catabolic process (GO:0042402)2.53611965
102amine catabolic process (GO:0009310)2.53611965
103lipid oxidation (GO:0034440)2.52628047
104monocarboxylic acid catabolic process (GO:0072329)2.52354884
105extracellular matrix assembly (GO:0085029)2.52297756
106insulin-like growth factor receptor signaling pathway (GO:0048009)2.52257560
107fatty acid oxidation (GO:0019395)2.52193753
108metanephric nephron tubule development (GO:0072234)2.52093975
109metanephric tubule development (GO:0072170)2.52093975
110acetyl-CoA metabolic process (GO:0006084)2.50906572
111carnitine shuttle (GO:0006853)2.47742510
112biotin metabolic process (GO:0006768)2.47616399
113plasma lipoprotein particle clearance (GO:0034381)2.46589244
114protein heterotrimerization (GO:0070208)2.46541466
115cell communication by electrical coupling (GO:0010644)2.45785735
116nucleobase catabolic process (GO:0046113)2.45683245
117fructose metabolic process (GO:0006000)2.45259769
118exogenous drug catabolic process (GO:0042738)2.44923001
119fatty acid catabolic process (GO:0009062)2.44645324
120drug transmembrane transport (GO:0006855)2.43823487
121very-low-density lipoprotein particle assembly (GO:0034379)2.43609942
122cell-substrate junction assembly (GO:0007044)2.43160253
123plasma lipoprotein particle assembly (GO:0034377)2.42877683
124plasma lipoprotein particle organization (GO:0071827)2.40916960
125dermatan sulfate biosynthetic process (GO:0030208)2.40262494
126vocalization behavior (GO:0071625)2.39844899
127skin morphogenesis (GO:0043589)2.39824907
128focal adhesion assembly (GO:0048041)2.39553352
129cell-substrate adherens junction assembly (GO:0007045)2.39553352
130positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.39526200
131regulation of ARF protein signal transduction (GO:0032012)2.39488813
132arginine metabolic process (GO:0006525)2.39443466
133flavonoid metabolic process (GO:0009812)2.38726973
134potassium ion homeostasis (GO:0055075)2.36533963
135negative regulation of fatty acid transport (GO:2000192)2.36427978
136negative regulation of protein localization to cell surface (GO:2000009)2.36426575
137potassium ion import (GO:0010107)2.35871890
138metanephric nephron epithelium development (GO:0072243)2.30057466
139synaptic vesicle exocytosis (GO:0016079)2.28261040
140neuronal ion channel clustering (GO:0045161)2.27927688
141kidney mesenchyme development (GO:0072074)2.27920769
142dermatan sulfate metabolic process (GO:0030205)2.26899976
143regulation of neuronal synaptic plasticity (GO:0048168)2.26608505
144regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.25677742
145adherens junction assembly (GO:0034333)2.25175875
146collagen fibril organization (GO:0030199)2.24535724
147locomotory exploration behavior (GO:0035641)2.24128159
148regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.23257751
149cell migration involved in heart development (GO:0060973)2.22556698
150astrocyte differentiation (GO:0048708)2.21543775
151actin filament depolymerization (GO:0030042)2.19775704
152positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.19741609
153negative regulation of hormone biosynthetic process (GO:0032353)2.19591048
154camera-type eye morphogenesis (GO:0048593)2.19484486
155neuron projection extension (GO:1990138)2.18024839
156positive regulation of synapse maturation (GO:0090129)2.17609713
157macroautophagy (GO:0016236)2.16354704
158embryonic retina morphogenesis in camera-type eye (GO:0060059)2.15117376
159positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.14825510
160regulation of axon extension involved in axon guidance (GO:0048841)2.13919552
161regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.13295816
162axon extension (GO:0048675)2.13024976
163metanephric mesenchyme development (GO:0072075)2.12660700
164plasma membrane repair (GO:0001778)2.10791260
165protein targeting to plasma membrane (GO:0072661)2.10493365
166hemidesmosome assembly (GO:0031581)2.10340606
167developmental cell growth (GO:0048588)2.09797407
168membrane assembly (GO:0071709)2.09480977
169vascular endothelial growth factor signaling pathway (GO:0038084)2.09197698
170cell volume homeostasis (GO:0006884)2.08485979
171myoblast fusion (GO:0007520)2.07903707
172peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.07680028
173activation of protein kinase A activity (GO:0034199)2.06443091
174positive regulation of blood vessel endothelial cell migration (GO:0043536)2.06404361
175negative regulation of synaptic transmission, GABAergic (GO:0032229)2.06249571
176positive regulation of axon extension (GO:0045773)2.05825364
177import into cell (GO:0098657)2.05450713
178metanephric epithelium development (GO:0072207)2.04932752
179axonal fasciculation (GO:0007413)2.04885322
180positive regulation of fibroblast migration (GO:0010763)2.04706266
181astrocyte development (GO:0014002)2.02549299
182endocardial cushion development (GO:0003197)2.00975162
183barbed-end actin filament capping (GO:0051016)1.99945839
184central nervous system myelination (GO:0022010)1.99884638
185axon ensheathment in central nervous system (GO:0032291)1.99884638
186regulation of female gonad development (GO:2000194)1.99687190
187cerebellar Purkinje cell layer development (GO:0021680)1.98828153
188chondroitin sulfate catabolic process (GO:0030207)1.97182822
189cell adhesion mediated by integrin (GO:0033627)1.96279809
190regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)1.96110430
191endodermal cell differentiation (GO:0035987)1.95992341
192regulation of cell communication by electrical coupling (GO:0010649)1.94222081
193positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.94186271
194negative regulation of hormone metabolic process (GO:0032351)1.93513210
195positive regulation of dendritic spine development (GO:0060999)1.93490665
196regulation of long-term neuronal synaptic plasticity (GO:0048169)1.93353986
197cardiac myofibril assembly (GO:0055003)1.92560909
198neuronal action potential propagation (GO:0019227)1.92484853
199negative regulation of dendrite morphogenesis (GO:0050774)1.92185426
200ensheathment of neurons (GO:0007272)1.91995478

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.05717641
2EZH2_22144423_ChIP-Seq_EOC_Human3.67082449
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.06629097
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.78556118
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.75431985
6GBX2_23144817_ChIP-Seq_PC3_Human2.74964616
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.42284548
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37427811
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.21667877
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.18288684
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.16064559
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15168692
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.12001882
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02135368
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93808788
16RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87354567
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85017433
18DROSHA_22980978_ChIP-Seq_HELA_Human1.67657572
19MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65130570
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64953605
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64953605
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63224630
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62033435
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61019943
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59127775
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56998420
27AR_21572438_ChIP-Seq_LNCaP_Human1.56676065
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.56241151
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55690616
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52316087
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.51479424
32* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.50722990
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49724058
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49583913
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49159061
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46661874
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46172684
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45936006
39SMAD4_21799915_ChIP-Seq_A2780_Human1.44411026
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43043072
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42212140
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.40203520
43BCAT_22108803_ChIP-Seq_LS180_Human1.39163586
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.38847482
45SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38545529
46* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38301936
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35961222
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35287830
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35206529
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32133731
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31772227
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.31560993
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.31379981
54KDM2B_26808549_Chip-Seq_K562_Human1.31271993
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31252305
56REST_21632747_ChIP-Seq_MESCs_Mouse1.30603494
57FOXA2_19822575_ChIP-Seq_HepG2_Human1.30115069
58* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29324955
59TAF15_26573619_Chip-Seq_HEK293_Human1.28625834
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28388187
61* TBX20_22328084_ChIP-Seq_HEART_Mouse1.27972078
62* TBX20_22080862_ChIP-Seq_HEART_Mouse1.27972078
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.27223433
64CJUN_26792858_Chip-Seq_BT549_Human1.27160609
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26907258
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25121952
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23836597
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22750179
69TP53_23651856_ChIP-Seq_MEFs_Mouse1.20933059
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20931263
71P300_19829295_ChIP-Seq_ESCs_Human1.19387810
72* STAT3_23295773_ChIP-Seq_U87_Human1.19115623
73* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18914757
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16569615
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16514234
76* AR_25329375_ChIP-Seq_VCAP_Human1.16369959
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15963790
78CLOCK_20551151_ChIP-Seq_293T_Human1.15678405
79TET1_21490601_ChIP-Seq_MESCs_Mouse1.14692361
80* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14051849
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13185702
82TP53_20018659_ChIP-ChIP_R1E_Mouse1.12679472
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12643578
84BRD4_25478319_ChIP-Seq_HGPS_Human1.11519115
85AHR_22903824_ChIP-Seq_MCF-7_Human1.11477577
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.10710580
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10693408
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.10325667
89* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08510151
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.08327406
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06975309
92RARB_27405468_Chip-Seq_BRAIN_Mouse1.06621079
93* EP300_21415370_ChIP-Seq_HL-1_Mouse1.06222093
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06130027
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.06113653
96POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05412294
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05080253
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04485686
99* TCF4_23295773_ChIP-Seq_U87_Human1.04089951
100* AR_19668381_ChIP-Seq_PC3_Human1.03755353
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02965234
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02583150
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01400502
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00200256
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00200256
106P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99720711
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.99501142
108PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99407877
109REST_18959480_ChIP-ChIP_MESCs_Mouse0.98740350
110WT1_19549856_ChIP-ChIP_CCG9911_Human0.97685100
111TP53_16413492_ChIP-PET_HCT116_Human0.96999546
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96921928
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96412231
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96320131
115TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95942522
116RXR_22108803_ChIP-Seq_LS180_Human0.95920070
117ESR1_20079471_ChIP-ChIP_T-47D_Human0.95749560
118GATA2_21666600_ChIP-Seq_HMVEC_Human0.95584667
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95421436
120ISL1_27105846_Chip-Seq_CPCs_Mouse0.95285185
121CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93838472
122HTT_18923047_ChIP-ChIP_STHdh_Human0.93613090
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93601035
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93601035
125SMAD_19615063_ChIP-ChIP_OVARY_Human0.93582346
126* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93565508
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93309353
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92782626
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92627208
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.92070609
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91779602
132FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90425573
133* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90404886
134* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89976017
135CBX2_27304074_Chip-Seq_ESCs_Mouse0.89694939
136ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89224872
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89044869
138SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88793636
139RUNX2_22187159_ChIP-Seq_PCA_Human0.88408915
140LXR_22292898_ChIP-Seq_THP-1_Human0.87734646
141IGF1R_20145208_ChIP-Seq_DFB_Human0.87256592
142TP53_18474530_ChIP-ChIP_U2OS_Human0.87171245
143* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86987214
144SMAD3_21741376_ChIP-Seq_HESCs_Human0.86480998
145TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85100896
146CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84698664
147YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84522387
148TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84180532

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.57583732
2MP0005360_urolithiasis5.42059737
3MP0005365_abnormal_bile_salt4.64125241
4MP0008438_abnormal_cutaneous_collagen4.37397012
5MP0005085_abnormal_gallbladder_physiolo4.31340637
6MP0008875_abnormal_xenobiotic_pharmacok3.24539635
7MP0003252_abnormal_bile_duct3.23943410
8MP0001958_emphysema2.80021738
9MP0010329_abnormal_lipoprotein_level2.70304998
10MP0005503_abnormal_tendon_morphology2.68457953
11MP0005275_abnormal_skin_tensile2.37327629
12MP0003195_calcinosis2.29231290
13MP0009780_abnormal_chondrocyte_physiolo2.28934524
14MP0003950_abnormal_plasma_membrane2.20681283
15MP0005332_abnormal_amino_acid2.18076567
16MP0003868_abnormal_feces_composition2.12264921
17MP0004859_abnormal_synaptic_plasticity2.11349893
18MP0004272_abnormal_basement_membrane1.93940930
19MP0003279_aneurysm1.87486711
20MP0005670_abnormal_white_adipose1.86604227
21MP0005623_abnormal_meninges_morphology1.81403777
22MP0005409_darkened_coat_color1.80145985
23MP0002837_dystrophic_cardiac_calcinosis1.76046311
24MP0004270_analgesia1.70185823
25MP0002118_abnormal_lipid_homeostasis1.70058018
26MP0004130_abnormal_muscle_cell1.67945737
27MP0004885_abnormal_endolymph1.67858084
28MP0005257_abnormal_intraocular_pressure1.66484981
29MP0003635_abnormal_synaptic_transmissio1.61309722
30MP0001666_abnormal_nutrient_absorption1.60765772
31MP0000749_muscle_degeneration1.60715710
32MP0005083_abnormal_biliary_tract1.60437133
33MP0002876_abnormal_thyroid_physiology1.50194683
34MP0004043_abnormal_pH_regulation1.45737235
35MP0001299_abnormal_eye_distance/1.41143511
36MP0005646_abnormal_pituitary_gland1.40446458
37MP0004019_abnormal_vitamin_homeostasis1.39369553
38MP0000759_abnormal_skeletal_muscle1.37969677
39MP0000534_abnormal_ureter_morphology1.37596084
40MP0003566_abnormal_cell_adhesion1.36848727
41MP0004036_abnormal_muscle_relaxation1.36147436
42MP0002063_abnormal_learning/memory/cond1.35613821
43MP0003091_abnormal_cell_migration1.35311393
44MP0001486_abnormal_startle_reflex1.34645919
45MP0002896_abnormal_bone_mineralization1.34636891
46MP0009046_muscle_twitch1.32964579
47MP0000733_abnormal_muscle_development1.32548060
48MP0004233_abnormal_muscle_weight1.32431378
49MP0009745_abnormal_behavioral_response1.29574041
50MP0002822_catalepsy1.28373855
51MP0000747_muscle_weakness1.27370114
52MP0009384_cardiac_valve_regurgitation1.26195145
53MP0000003_abnormal_adipose_tissue1.26156047
54MP0003690_abnormal_glial_cell1.24535579
55MP0002064_seizures1.22087980
56MP0003283_abnormal_digestive_organ1.20051391
57MP0002572_abnormal_emotion/affect_behav1.19259054
58MP0010368_abnormal_lymphatic_system1.18654678
59MP0005023_abnormal_wound_healing1.16012059
60MP0005647_abnormal_sex_gland1.15043826
61MP0000609_abnormal_liver_physiology1.14096895
62MP0005535_abnormal_body_temperature1.13479102
63MP0000920_abnormal_myelination1.12129686
64MP0000566_synostosis1.09321206
65MP0004087_abnormal_muscle_fiber1.09279346
66MP0002295_abnormal_pulmonary_circulatio1.08177851
67MP0005551_abnormal_eye_electrophysiolog1.07490515
68MP0002249_abnormal_larynx_morphology1.07406917
69MP0001501_abnormal_sleep_pattern1.05328512
70MP0001984_abnormal_olfaction1.04648146
71MP0003880_abnormal_central_pattern1.04282764
72MP0005187_abnormal_penis_morphology1.03974925
73MP0001502_abnormal_circadian_rhythm1.03929207
74MP0003806_abnormal_nucleotide_metabolis1.03860756
75MP0002060_abnormal_skin_morphology1.02008003
76MP0003329_amyloid_beta_deposits1.01180476
77MP0002269_muscular_atrophy1.00934836
78MP0002138_abnormal_hepatobiliary_system1.00760773
79MP0008961_abnormal_basal_metabolism0.99803513
80MP0001177_atelectasis0.99584764
81MP0002272_abnormal_nervous_system0.98948054
82MP0005508_abnormal_skeleton_morphology0.98600394
83MP0000762_abnormal_tongue_morphology0.98330373
84MP0010386_abnormal_urinary_bladder0.98294215
85MP0002909_abnormal_adrenal_gland0.98047443
86MP0004084_abnormal_cardiac_muscle0.97536056
87MP0003045_fibrosis0.97424765
88MP0005584_abnormal_enzyme/coenzyme_acti0.96492902
89MP0005423_abnormal_somatic_nervous0.95511540
90MP0009250_abnormal_appendicular_skeleto0.94736907
91MP0001348_abnormal_lacrimal_gland0.94645730
92MP0003633_abnormal_nervous_system0.93277662
93MP0003634_abnormal_glial_cell0.92894329
94MP0002971_abnormal_brown_adipose0.92360188
95MP0002078_abnormal_glucose_homeostasis0.91855585
96MP0000751_myopathy0.91184382
97MP0002734_abnormal_mechanical_nocicepti0.90871613
98MP0000462_abnormal_digestive_system0.90153678
99MP0010030_abnormal_orbit_morphology0.89949574
100MP0000013_abnormal_adipose_tissue0.89900651
101MP0000767_abnormal_smooth_muscle0.89659869
102MP0004134_abnormal_chest_morphology0.89209889
103MP0005620_abnormal_muscle_contractility0.88853762
104MP0002067_abnormal_sensory_capabilities0.88789100
105MP0004215_abnormal_myocardial_fiber0.87731714
106MP0009697_abnormal_copulation0.87122987
107MP0005369_muscle_phenotype0.86355132
108MP0000428_abnormal_craniofacial_morphol0.85597156
109MP0003191_abnormal_cellular_cholesterol0.85084222
110MP0005666_abnormal_adipose_tissue0.84771809
111MP0001440_abnormal_grooming_behavior0.84017713
112MP0005319_abnormal_enzyme/_coenzyme0.83934932
113MP0005375_adipose_tissue_phenotype0.83486706
114MP0000778_abnormal_nervous_system0.82077758
115MP0003705_abnormal_hypodermis_morpholog0.81496484
116MP0003879_abnormal_hair_cell0.81450316
117MP0004858_abnormal_nervous_system0.80528536
118MP0006138_congestive_heart_failure0.80039765
119MP0004085_abnormal_heartbeat0.79694803
120MP0004145_abnormal_muscle_electrophysio0.78699378
121MP0004924_abnormal_behavior0.78202863
122MP0005386_behavior/neurological_phenoty0.78202863
123MP0002557_abnormal_social/conspecific_i0.77448122
124MP0002108_abnormal_muscle_morphology0.76706845
125MP0001764_abnormal_homeostasis0.76512497
126MP0001879_abnormal_lymphatic_vessel0.75950978
127MP0002089_abnormal_postnatal_growth/wei0.75887822
128MP0006276_abnormal_autonomic_nervous0.75752676
129MP0005334_abnormal_fat_pad0.75473662
130MP0005595_abnormal_vascular_smooth0.75282864
131MP0003942_abnormal_urinary_system0.75272867
132MP0009840_abnormal_foam_cell0.74515646
133MP0003011_delayed_dark_adaptation0.74306833
134MP0000579_abnormal_nail_morphology0.72481266
135MP0001542_abnormal_bone_strength0.72468419
136MP0003631_nervous_system_phenotype0.72312034
137MP0002106_abnormal_muscle_physiology0.71428532
138MP0002234_abnormal_pharynx_morphology0.71244629
139MP0000163_abnormal_cartilage_morphology0.70610821
140MP0008569_lethality_at_weaning0.69747473
141MP0002168_other_aberrant_phenotype0.69701815
142MP0003953_abnormal_hormone_level0.69622776
143MP0009643_abnormal_urine_homeostasis0.69140498
144MP0000639_abnormal_adrenal_gland0.68251141
145MP0000604_amyloidosis0.67782858
146MP0002066_abnormal_motor_capabilities/c0.67299022
147MP0005220_abnormal_exocrine_pancreas0.66320881
148MP0005171_absent_coat_pigmentation0.65999261
149MP0003646_muscle_fatigue0.65696680
150MP0005377_hearing/vestibular/ear_phenot0.65323524
151MP0003878_abnormal_ear_physiology0.65323524
152MP0000230_abnormal_systemic_arterial0.65147247
153MP0003137_abnormal_impulse_conducting0.65145317
154MP0001968_abnormal_touch/_nociception0.64110488
155MP0001661_extended_life_span0.64025032
156MP0001270_distended_abdomen0.64025028
157MP0005448_abnormal_energy_balance0.63887555
158MP0005248_abnormal_Harderian_gland0.63327347

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.88517122
2Intrahepatic cholestasis (HP:0001406)4.78888486
3Protrusio acetabuli (HP:0003179)4.75289767
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.28332654
5Xanthomatosis (HP:0000991)4.07871676
6Premature rupture of membranes (HP:0001788)4.05648382
7Type 1 muscle fiber predominance (HP:0003803)4.00143842
8Prolonged partial thromboplastin time (HP:0003645)3.96839326
9Hyperlipoproteinemia (HP:0010980)3.93547027
10Hypoalphalipoproteinemia (HP:0003233)3.77828436
11Epidermoid cyst (HP:0200040)3.75653368
12Complement deficiency (HP:0004431)3.68867152
13Ketosis (HP:0001946)3.61934568
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.59207898
15Hypobetalipoproteinemia (HP:0003563)3.41021923
16Hypolipoproteinemia (HP:0010981)3.38965487
17Aortic aneurysm (HP:0004942)3.37897369
18Shallow orbits (HP:0000586)3.35492196
19Hyperglycinuria (HP:0003108)3.31361031
20Hyperventilation (HP:0002883)3.23328455
21Ketoacidosis (HP:0001993)3.23114104
22Hyperglycinemia (HP:0002154)3.23063187
23Vascular tortuosity (HP:0004948)3.22330008
24Hyperammonemia (HP:0001987)3.18887461
25Abnormality of glycine metabolism (HP:0010895)3.17200691
26Abnormality of serine family amino acid metabolism (HP:0010894)3.17200691
27Ankle contracture (HP:0006466)3.12920298
28Spinal rigidity (HP:0003306)3.11946209
29Obstructive sleep apnea (HP:0002870)3.04558266
30Hypoglycemic coma (HP:0001325)3.02715985
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.02683793
32Abnormality of glutamine family amino acid metabolism (HP:0010902)2.99187325
33Conjugated hyperbilirubinemia (HP:0002908)2.86214150
34Aortic dissection (HP:0002647)2.85639078
35Arterial tortuosity (HP:0005116)2.81538520
36Abnormality of sulfur amino acid metabolism (HP:0004339)2.79509637
37Increased variability in muscle fiber diameter (HP:0003557)2.77390072
38Abnormality of aspartate family amino acid metabolism (HP:0010899)2.75607113
39Bladder diverticulum (HP:0000015)2.75413168
40Neonatal short-limb short stature (HP:0008921)2.66198573
41Hypoglycemic seizures (HP:0002173)2.62288677
42Focal motor seizures (HP:0011153)2.61080480
43Broad metatarsal (HP:0001783)2.59645278
44Hyporeflexia of lower limbs (HP:0002600)2.58605733
45Overgrowth (HP:0001548)2.56980258
46Bundle branch block (HP:0011710)2.56742944
47Abnormality of the common coagulation pathway (HP:0010990)2.56694205
48Wormian bones (HP:0002645)2.54885406
49Hyperinsulinemic hypoglycemia (HP:0000825)2.53390428
50Atrophic scars (HP:0001075)2.52329240
51Gout (HP:0001997)2.51795601
52Abnormality of methionine metabolism (HP:0010901)2.51386452
53Joint hemorrhage (HP:0005261)2.51005156
54Fat malabsorption (HP:0002630)2.49625417
55Blue irides (HP:0000635)2.47419148
56Mildly elevated creatine phosphokinase (HP:0008180)2.39658912
57Slender build (HP:0001533)2.38793767
58Increased connective tissue (HP:0009025)2.38544862
59Hyperglycemia (HP:0003074)2.37982878
60Cerebral aneurysm (HP:0004944)2.36782218
61Abnormality of skeletal muscle fiber size (HP:0012084)2.35446808
62Mitral stenosis (HP:0001718)2.30016016
63Round ear (HP:0100830)2.29389927
64Abnormality of fatty-acid metabolism (HP:0004359)2.28242207
65Skin nodule (HP:0200036)2.28110898
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.27910344
67Abnormality of complement system (HP:0005339)2.27003280
68Hypercholesterolemia (HP:0003124)2.26105868
69Neurofibrillary tangles (HP:0002185)2.26086064
70Bowel diverticulosis (HP:0005222)2.25805835
71Muscle fiber inclusion bodies (HP:0100299)2.25417103
72Enlarged kidneys (HP:0000105)2.25373365
73Follicular hyperkeratosis (HP:0007502)2.23820013
74Hyperacusis (HP:0010780)2.23243770
75Hypochromic microcytic anemia (HP:0004840)2.19446856
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.19020764
77Fragile skin (HP:0001030)2.18515980
78Nemaline bodies (HP:0003798)2.17703545
79Myocardial infarction (HP:0001658)2.16218865
80Delayed CNS myelination (HP:0002188)2.14702753
81Progressive cerebellar ataxia (HP:0002073)2.14046662
82Alkalosis (HP:0001948)2.13712203
83Abnormality of the intrinsic pathway (HP:0010989)2.13512554
84Abnormality of purine metabolism (HP:0004352)2.11222738
85Exercise-induced myalgia (HP:0003738)2.10485511
86Status epilepticus (HP:0002133)2.09115474
87Metabolic acidosis (HP:0001942)2.08018675
88Abnormality of the lower motor neuron (HP:0002366)2.07470373
89Soft skin (HP:0000977)2.07335531
90Ulnar bowing (HP:0003031)2.06756649
91Focal seizures (HP:0007359)2.06440083
92Mitral regurgitation (HP:0001653)2.06362862
93Cerebral inclusion bodies (HP:0100314)2.03387281
94Confusion (HP:0001289)2.01636630
95Hyperextensible skin (HP:0000974)2.01358222
96Chronic hepatic failure (HP:0100626)2.00175015
97Vertebral compression fractures (HP:0002953)1.98600858
98Advanced eruption of teeth (HP:0006288)1.97970933
99Hyperbilirubinemia (HP:0002904)1.97794587
100Wrist flexion contracture (HP:0001239)1.97572005
101Hypokalemic alkalosis (HP:0001949)1.96967781
102Hypoplasia of the iris (HP:0007676)1.96316955
103Hypoventilation (HP:0002791)1.95539486
104Renovascular hypertension (HP:0100817)1.95032472
105Aplasia involving bones of the extremities (HP:0009825)1.94254521
106Aplasia involving bones of the upper limbs (HP:0009823)1.94254521
107Aplasia of the phalanges of the hand (HP:0009802)1.94254521
108Insomnia (HP:0100785)1.94130366
109Supranuclear gaze palsy (HP:0000605)1.92910599
110Abnormality of serum amino acid levels (HP:0003112)1.92281017
111Genu recurvatum (HP:0002816)1.90436815
112Turricephaly (HP:0000262)1.89512101
113Spontaneous abortion (HP:0005268)1.89351609
114Action tremor (HP:0002345)1.88384919
115Cervical subluxation (HP:0003308)1.87312964
116Fair hair (HP:0002286)1.86109180
117Natal tooth (HP:0000695)1.85903347
118Distal lower limb muscle weakness (HP:0009053)1.85794825
119Aneurysm (HP:0002617)1.85594629
120Hepatocellular carcinoma (HP:0001402)1.84523130
121Scanning speech (HP:0002168)1.84224628
122Spinal cord compression (HP:0002176)1.83294491
123Difficulty running (HP:0009046)1.83212752
124Coronal craniosynostosis (HP:0004440)1.82762503
125Neonatal onset (HP:0003623)1.82433024
126Hyperactive renin-angiotensin system (HP:0000841)1.81768020
127Hepatoblastoma (HP:0002884)1.81717932
128Back pain (HP:0003418)1.81237619
129Symptomatic seizures (HP:0011145)1.79969581
130Febrile seizures (HP:0002373)1.79919712
131Joint laxity (HP:0001388)1.79545590
132Dysmetric saccades (HP:0000641)1.78179094
133Hyperuricemia (HP:0002149)1.77838778
134Increased purine levels (HP:0004368)1.77838778
135Blue sclerae (HP:0000592)1.76861646
136Increased circulating renin level (HP:0000848)1.76730295
137Dysdiadochokinesis (HP:0002075)1.76678622
138Generalized tonic-clonic seizures (HP:0002069)1.76496027
139Abnormal atrioventricular conduction (HP:0005150)1.76067634
140Mild short stature (HP:0003502)1.75621856
141Upper limb amyotrophy (HP:0009129)1.75522348
142Distal upper limb amyotrophy (HP:0007149)1.75522348
143Impaired vibratory sensation (HP:0002495)1.75360658
144Bradycardia (HP:0001662)1.74665317
145Truncal ataxia (HP:0002078)1.73804375
146Torticollis (HP:0000473)1.72995404
147Chorioretinal atrophy (HP:0000533)1.72782569
148Lower limb amyotrophy (HP:0007210)1.72549822
149Scapular winging (HP:0003691)1.71496120
150Sensorimotor neuropathy (HP:0007141)1.70304387
151Limited hip movement (HP:0008800)1.69859164
152Mitral valve prolapse (HP:0001634)1.69323405
153Urinary bladder sphincter dysfunction (HP:0002839)1.69197131
154Abnormality of nucleobase metabolism (HP:0010932)1.68805803
155Genetic anticipation (HP:0003743)1.68252738
156Abnormality of the calf musculature (HP:0001430)1.67937373
157Impaired vibration sensation in the lower limbs (HP:0002166)1.67513048
158Abnormal gallbladder morphology (HP:0012437)1.67417410
159Flat cornea (HP:0007720)1.67302512
160Myokymia (HP:0002411)1.67060467
161Abnormality of dentin (HP:0010299)1.66977825
162Facial shape deformation (HP:0011334)1.66781750
163Potter facies (HP:0002009)1.66781750
164Elbow flexion contracture (HP:0002987)1.66297590
165Vascular calcification (HP:0004934)1.66127669
166Striae distensae (HP:0001065)1.65911788
167Cardiovascular calcification (HP:0011915)1.63814905
168Wide anterior fontanel (HP:0000260)1.62975775
169Asymmetric septal hypertrophy (HP:0001670)1.62287765
170Pigmentary retinal degeneration (HP:0001146)1.61603270
171Aortic regurgitation (HP:0001659)1.61195095
172Hemiplegia (HP:0002301)1.60491069
173Osteolytic defects of the hand bones (HP:0009699)1.59983247
174Osteolytic defects of the phalanges of the hand (HP:0009771)1.59983247
175Abnormal social behavior (HP:0012433)1.59362252
176Impaired social interactions (HP:0000735)1.59362252
177Epileptic encephalopathy (HP:0200134)1.59310701
178Dilatation of the ascending aorta (HP:0005111)1.59064782
179Postural instability (HP:0002172)1.58996611
180Heart block (HP:0012722)1.57814325
181Long toe (HP:0010511)1.57510408
182Short nail (HP:0001799)1.56946949
183Renal duplication (HP:0000075)1.56734271
184Hypercortisolism (HP:0001578)1.56699853
185Knee flexion contracture (HP:0006380)1.56096568
186Hip contracture (HP:0003273)1.55259129
187Distal lower limb amyotrophy (HP:0008944)1.53549892
188Complete atrioventricular canal defect (HP:0001674)1.52318983
189Limb-girdle muscle weakness (HP:0003325)1.51730623
190Infantile muscular hypotonia (HP:0008947)1.51515441
191Hyperparathyroidism (HP:0000843)1.50891787
192Tibial bowing (HP:0002982)1.50891037
193Muscle fiber splitting (HP:0003555)1.49374723

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK3.57774749
2LATS12.81513090
3INSRR2.77943220
4SIK12.44190597
5EPHA42.35766413
6NTRK32.14025628
7SGK22.12473544
8TTN2.10117448
9CASK1.96407213
10FGFR21.89799188
11NTRK21.87517539
12SGK4941.86550200
13SGK2231.86550200
14MAP3K41.83598531
15SGK31.82253764
16PTK21.80991288
17MAP2K41.78282401
18CAMK1G1.71954600
19DAPK21.70976909
20MYLK1.68950544
21BCKDK1.68179006
22AKT31.67430181
23CDK121.66509353
24PRKD31.66051630
25ERBB41.64671192
26FGFR41.61261805
27MARK11.57951439
28PINK11.54898417
29EEF2K1.49427390
30MAP2K71.46706614
31TNIK1.46326563
32CAMK1D1.43640288
33MET1.37611978
34PHKG21.35933206
35PHKG11.35933206
36STK381.32944509
37ARAF1.31380275
38ICK1.25649843
39PAK21.25488155
40KSR21.24888835
41NEK91.24282375
42WNK31.21580824
43FRK1.18481022
44LIMK11.17741020
45TRIB31.16536942
46PAK61.15818481
47MTOR1.15238757
48PRKD21.15191408
49RIPK11.14107649
50MOS1.12961463
51CAMK2B1.11522105
52PDGFRB1.09532581
53TRPM71.09095754
54TESK11.08004191
55WNK41.06127019
56MAP3K131.02529116
57PRKCH1.00993509
58NTRK11.00922647
59CAMK2G0.99879528
60MINK10.97357806
61LMTK20.96890896
62PDK30.95836717
63PDK40.95836717
64MAP3K70.95510824
65PKN10.91463392
66PRPF4B0.90725298
67PRKAA20.89836104
68EPHA30.87138520
69SCYL20.85334078
70ROCK20.83783938
71PRKCG0.83662612
72CAMKK10.81020337
73RPS6KA20.81010036
74NUAK10.80978932
75OXSR10.80615379
76MAPK120.80135409
77DMPK0.79777108
78PRKAA10.79290530
79UHMK10.78302595
80STK38L0.78196628
81FGFR30.77266048
82CAMK2D0.74921315
83PDK20.74264044
84MAPK130.74227929
85RET0.73873985
86CDC42BPA0.73848050
87SGK10.73432430
88MAP2K10.73392985
89FER0.72011727
90PDGFRA0.71427912
91EPHB20.70560703
92MELK0.70515282
93MAP3K90.70194421
94MAP3K60.69560015
95PAK30.68990127
96TYRO30.68930932
97CDK50.68505277
98MAPKAPK30.67042931
99CAMK10.65421387
100CAMK2A0.65411607
101TIE10.65124822
102PRKCZ0.64866209
103CAMK40.64821049
104PTK2B0.64532832
105IRAK20.64135860
106MAPK100.62765986
107ERN10.62499677
108MARK20.62150489
109TAOK30.60540319
110CDK190.59303463
111MAPK70.58274733
112WNK10.57840482
113DYRK1A0.56406137
114MAP3K10.56403300
115PIK3CA0.56340638
116MAPK110.55847528
117PRKCE0.54481839
118LATS20.54299290
119PKN20.54085163
120PRKACG0.53283702
121OBSCN0.52512840
122IRAK10.52388089
123PDK10.52065766
124KSR10.52041327
125RPS6KA30.51344618
126GRK50.50511291
127STK110.50187346
128CSNK1G20.49578669
129PRKD10.48860516
130PDPK10.48730821
131ABL20.48583736
132DDR20.48480708
133BRAF0.48319668
134ROCK10.47540351
135ERBB20.47442240
136EPHB10.47063146
137MAP3K20.46995905
138NEK60.46289209
139MST1R0.45556102

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.24544706
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.30238857
3Arginine biosynthesis_Homo sapiens_hsa002202.53123815
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.49719133
5Butanoate metabolism_Homo sapiens_hsa006502.40854292
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.36013149
7Fatty acid degradation_Homo sapiens_hsa000712.30005799
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.15939767
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05706319
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01182130
11Fatty acid metabolism_Homo sapiens_hsa012122.01072021
12Tryptophan metabolism_Homo sapiens_hsa003801.97251533
13Propanoate metabolism_Homo sapiens_hsa006401.90934040
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.89650166
15PPAR signaling pathway_Homo sapiens_hsa033201.88092529
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.85871806
17Complement and coagulation cascades_Homo sapiens_hsa046101.83399095
18ECM-receptor interaction_Homo sapiens_hsa045121.82218294
19Bile secretion_Homo sapiens_hsa049761.69265827
20Peroxisome_Homo sapiens_hsa041461.63084617
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59823739
22Dilated cardiomyopathy_Homo sapiens_hsa054141.58410412
23Focal adhesion_Homo sapiens_hsa045101.57938769
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49922190
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49089535
26Fatty acid biosynthesis_Homo sapiens_hsa000611.44550456
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34624993
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.29435205
29Glioma_Homo sapiens_hsa052141.27134298
30beta-Alanine metabolism_Homo sapiens_hsa004101.26561062
31Gap junction_Homo sapiens_hsa045401.26416035
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24755116
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.22118369
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.19917315
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19583405
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16247026
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.15425914
38Estrogen signaling pathway_Homo sapiens_hsa049151.14817474
39ABC transporters_Homo sapiens_hsa020101.12589155
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11542851
41Pyruvate metabolism_Homo sapiens_hsa006201.10555126
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.08603342
43Oxytocin signaling pathway_Homo sapiens_hsa049211.08447581
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.07879055
45Nicotine addiction_Homo sapiens_hsa050331.05061115
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04984609
47Prion diseases_Homo sapiens_hsa050201.04741671
48mTOR signaling pathway_Homo sapiens_hsa041501.03913546
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02936370
50Fatty acid elongation_Homo sapiens_hsa000621.01863035
51GnRH signaling pathway_Homo sapiens_hsa049121.01378564
52Inositol phosphate metabolism_Homo sapiens_hsa005621.00813032
53Protein digestion and absorption_Homo sapiens_hsa049741.00716740
54Lysine degradation_Homo sapiens_hsa003101.00367913
55Chemical carcinogenesis_Homo sapiens_hsa052040.99755524
56GABAergic synapse_Homo sapiens_hsa047270.97010660
57Retinol metabolism_Homo sapiens_hsa008300.96393418
58Histidine metabolism_Homo sapiens_hsa003400.95587072
59ErbB signaling pathway_Homo sapiens_hsa040120.93916379
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93764850
61Melanogenesis_Homo sapiens_hsa049160.91964640
62Selenocompound metabolism_Homo sapiens_hsa004500.90916784
63Caffeine metabolism_Homo sapiens_hsa002320.90579275
64Glycerolipid metabolism_Homo sapiens_hsa005610.89711955
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89323561
66Starch and sucrose metabolism_Homo sapiens_hsa005000.87134632
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86606953
68Adherens junction_Homo sapiens_hsa045200.86335370
69Phenylalanine metabolism_Homo sapiens_hsa003600.86290816
70Sulfur metabolism_Homo sapiens_hsa009200.86000456
71Circadian entrainment_Homo sapiens_hsa047130.85014696
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83931496
73Proteoglycans in cancer_Homo sapiens_hsa052050.83834806
74Glutamatergic synapse_Homo sapiens_hsa047240.83755602
75Insulin secretion_Homo sapiens_hsa049110.83447929
76Endometrial cancer_Homo sapiens_hsa052130.82265688
77Fat digestion and absorption_Homo sapiens_hsa049750.82251542
78Dorso-ventral axis formation_Homo sapiens_hsa043200.81083971
79Vitamin digestion and absorption_Homo sapiens_hsa049770.80968892
80Long-term depression_Homo sapiens_hsa047300.80960465
81Amoebiasis_Homo sapiens_hsa051460.80270705
82Pancreatic secretion_Homo sapiens_hsa049720.80015777
83Tyrosine metabolism_Homo sapiens_hsa003500.79747260
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76994963
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.75679228
86Melanoma_Homo sapiens_hsa052180.74950371
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74342144
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73432319
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73189810
90Hippo signaling pathway_Homo sapiens_hsa043900.71752302
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71431946
92Axon guidance_Homo sapiens_hsa043600.70932758
93Renal cell carcinoma_Homo sapiens_hsa052110.70561468
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.68598115
95Circadian rhythm_Homo sapiens_hsa047100.68363398
96Vitamin B6 metabolism_Homo sapiens_hsa007500.67678532
97Morphine addiction_Homo sapiens_hsa050320.67220590
98Glucagon signaling pathway_Homo sapiens_hsa049220.66974471
99Staphylococcus aureus infection_Homo sapiens_hsa051500.66958692
100Steroid biosynthesis_Homo sapiens_hsa001000.66200278
101Rap1 signaling pathway_Homo sapiens_hsa040150.65710900
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65489532
103Carbon metabolism_Homo sapiens_hsa012000.65307059
104Tight junction_Homo sapiens_hsa045300.64709485
105VEGF signaling pathway_Homo sapiens_hsa043700.63673600
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63602965
107Choline metabolism in cancer_Homo sapiens_hsa052310.63093698
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62992469
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.62311212
110Taste transduction_Homo sapiens_hsa047420.62247780
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.61906859
112Salivary secretion_Homo sapiens_hsa049700.61437529
113Type II diabetes mellitus_Homo sapiens_hsa049300.61430798
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59528477
115Biosynthesis of amino acids_Homo sapiens_hsa012300.59451144
116Chronic myeloid leukemia_Homo sapiens_hsa052200.58406486
117Amphetamine addiction_Homo sapiens_hsa050310.56638498
118Gastric acid secretion_Homo sapiens_hsa049710.56634467
119Vibrio cholerae infection_Homo sapiens_hsa051100.56440585
120Renin secretion_Homo sapiens_hsa049240.56381406
121Ras signaling pathway_Homo sapiens_hsa040140.55931552
122Olfactory transduction_Homo sapiens_hsa047400.55640002
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55485131
124Insulin resistance_Homo sapiens_hsa049310.54642506
125MicroRNAs in cancer_Homo sapiens_hsa052060.54283685
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54096547
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.53996201
128Non-small cell lung cancer_Homo sapiens_hsa052230.53959724
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53614795
130Long-term potentiation_Homo sapiens_hsa047200.49829127
131Synaptic vesicle cycle_Homo sapiens_hsa047210.49779705
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48408470
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47344323
134Arginine and proline metabolism_Homo sapiens_hsa003300.46652116
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.46397083
136cAMP signaling pathway_Homo sapiens_hsa040240.45240502
137Calcium signaling pathway_Homo sapiens_hsa040200.43969006
138Ovarian steroidogenesis_Homo sapiens_hsa049130.43337089
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.42586300
140Cocaine addiction_Homo sapiens_hsa050300.41624587
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41264506
142AMPK signaling pathway_Homo sapiens_hsa041520.40514066
143Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39801898
144Dopaminergic synapse_Homo sapiens_hsa047280.38783453
145Cholinergic synapse_Homo sapiens_hsa047250.38746254
146Insulin signaling pathway_Homo sapiens_hsa049100.37578151
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.36471683
148Thyroid hormone synthesis_Homo sapiens_hsa049180.36392815
149Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33300253
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32277126
151Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31885593

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