ZIC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cerebellar granule cell differentiation (GO:0021707)8.28760680
2response to pheromone (GO:0019236)7.44020552
3cerebellar Purkinje cell differentiation (GO:0021702)6.19164895
4locomotory exploration behavior (GO:0035641)5.97064999
5neuronal action potential propagation (GO:0019227)5.89642154
6cell differentiation in hindbrain (GO:0021533)5.82302357
7gamma-aminobutyric acid transport (GO:0015812)5.79521644
8G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.75372858
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.53931442
10cellular potassium ion homeostasis (GO:0030007)5.40716447
11glutamate receptor signaling pathway (GO:0007215)5.35524199
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.20146482
13sodium ion export (GO:0071436)5.19721666
14regulation of short-term neuronal synaptic plasticity (GO:0048172)5.19177793
15positive regulation of synapse maturation (GO:0090129)5.17389165
16vocalization behavior (GO:0071625)4.99989802
17synaptic vesicle maturation (GO:0016188)4.94083223
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.90056805
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.89457426
20synaptic transmission, glutamatergic (GO:0035249)4.81859690
21layer formation in cerebral cortex (GO:0021819)4.63041107
22neurotransmitter secretion (GO:0007269)4.60798397
23pyrimidine nucleobase catabolic process (GO:0006208)4.58992393
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.55010806
25presynaptic membrane assembly (GO:0097105)4.40115171
26regulation of synaptic vesicle exocytosis (GO:2000300)4.26563478
27regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.23912737
28long-term memory (GO:0007616)4.20968877
29positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.18118876
30neuron-neuron synaptic transmission (GO:0007270)4.17974604
31regulation of synapse maturation (GO:0090128)4.17281936
32synaptic vesicle exocytosis (GO:0016079)4.14267731
33potassium ion import (GO:0010107)4.10720693
34establishment of mitochondrion localization (GO:0051654)4.08055053
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.01486736
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.93426074
37dendrite morphogenesis (GO:0048813)3.92371782
38regulation of glutamate receptor signaling pathway (GO:1900449)3.90756913
39neuromuscular process controlling posture (GO:0050884)3.90164712
40glutamate secretion (GO:0014047)3.88583561
41establishment of nucleus localization (GO:0040023)3.88564281
42C4-dicarboxylate transport (GO:0015740)3.86488538
43exploration behavior (GO:0035640)3.83677606
44cell communication by electrical coupling (GO:0010644)3.83544111
45transmission of nerve impulse (GO:0019226)3.83066176
46cerebral cortex radially oriented cell migration (GO:0021799)3.80714299
47neuromuscular process controlling balance (GO:0050885)3.71994181
48neurotransmitter transport (GO:0006836)3.70951027
49neurotransmitter-gated ion channel clustering (GO:0072578)3.69057353
50nucleobase catabolic process (GO:0046113)3.62074754
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.60463167
52regulation of synaptic vesicle transport (GO:1902803)3.59919233
53central nervous system myelination (GO:0022010)3.58766993
54axon ensheathment in central nervous system (GO:0032291)3.58766993
55neuron cell-cell adhesion (GO:0007158)3.55942082
56potassium ion homeostasis (GO:0055075)3.55524083
57protein localization to synapse (GO:0035418)3.54634255
58membrane depolarization during action potential (GO:0086010)3.52969844
59positive regulation of synapse assembly (GO:0051965)3.47179056
60regulation of neurotransmitter levels (GO:0001505)3.45124437
61cellular sodium ion homeostasis (GO:0006883)3.43980966
62mating behavior (GO:0007617)3.43417246
63axonal fasciculation (GO:0007413)3.42705993
64mitochondrion transport along microtubule (GO:0047497)3.42488061
65establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.42488061
66dendritic spine morphogenesis (GO:0060997)3.42375848
67glycine transport (GO:0015816)3.40457143
68regulation of postsynaptic membrane potential (GO:0060078)3.38923163
69presynaptic membrane organization (GO:0097090)3.36550414
70axon extension (GO:0048675)3.36488139
71regulation of long-term neuronal synaptic plasticity (GO:0048169)3.34362360
72auditory behavior (GO:0031223)3.32881320
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.29707703
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27295756
75synaptic vesicle endocytosis (GO:0048488)3.26667450
76response to auditory stimulus (GO:0010996)3.26007528
77membrane depolarization (GO:0051899)3.25727994
78positive regulation of potassium ion transmembrane transport (GO:1901381)3.25686580
79synaptic vesicle docking involved in exocytosis (GO:0016081)3.25531598
80* adult walking behavior (GO:0007628)3.24651731
81positive regulation of membrane potential (GO:0045838)3.22946270
82negative regulation of synaptic transmission, GABAergic (GO:0032229)3.21312074
83central nervous system projection neuron axonogenesis (GO:0021952)3.21121642
84gonadal mesoderm development (GO:0007506)3.19761267
85regulation of neurotransmitter secretion (GO:0046928)3.19662902
86camera-type eye morphogenesis (GO:0048593)3.19496002
87neuronal ion channel clustering (GO:0045161)3.19025322
88regulation of neuronal synaptic plasticity (GO:0048168)3.18286784
89cerebellar Purkinje cell layer development (GO:0021680)3.17822052
90multicellular organismal movement (GO:0050879)3.16576305
91musculoskeletal movement (GO:0050881)3.16576305
92neuron recognition (GO:0008038)3.15170809
93cerebellum development (GO:0021549)3.14541304
94long term synaptic depression (GO:0060292)3.14019887
95membrane hyperpolarization (GO:0060081)3.13535886
96positive regulation of dendritic spine morphogenesis (GO:0061003)3.12822353
97mechanosensory behavior (GO:0007638)3.12220456
98startle response (GO:0001964)3.11729651
99negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.07229847
100suckling behavior (GO:0001967)3.07060275
101negative regulation of hormone biosynthetic process (GO:0032353)3.06771118
102negative regulation of hormone metabolic process (GO:0032351)3.06771118
103acidic amino acid transport (GO:0015800)3.06461768
104apical protein localization (GO:0045176)3.06172322
105synapse assembly (GO:0007416)3.05642255
106spinal cord association neuron differentiation (GO:0021527)3.04983526
107prepulse inhibition (GO:0060134)3.04738345
108cell migration in hindbrain (GO:0021535)3.03903545
109dendritic spine organization (GO:0097061)3.03415321
110retinal ganglion cell axon guidance (GO:0031290)3.00685315
111regulation of synaptic transmission, glutamatergic (GO:0051966)3.00412343
112postsynaptic membrane organization (GO:0001941)2.99009970
113positive regulation of dendritic spine development (GO:0060999)2.97941907
114negative regulation of protein localization to cell surface (GO:2000009)2.97822035
115L-glutamate transport (GO:0015813)2.94320190
116neuron projection extension (GO:1990138)2.92007987
117regulation of neurotransmitter transport (GO:0051588)2.91071241
118neuromuscular process (GO:0050905)2.90805198
119regulation of voltage-gated calcium channel activity (GO:1901385)2.90600551
120regulation of synapse structural plasticity (GO:0051823)2.90482959
121synapse organization (GO:0050808)2.84322394
122negative regulation of catenin import into nucleus (GO:0035414)2.83354131
123dendrite development (GO:0016358)2.83000097
124neuronal stem cell maintenance (GO:0097150)2.79535112
125regulation of axon guidance (GO:1902667)2.78196126
126neuromuscular synaptic transmission (GO:0007274)2.74515484
127regulation of axon extension involved in axon guidance (GO:0048841)2.73791238
128axon cargo transport (GO:0008088)2.69663611
129regulation of synapse assembly (GO:0051963)2.69352616

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.90779125
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.48284846
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.41197055
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16722687
5IKZF1_21737484_ChIP-ChIP_HCT116_Human3.13992606
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse3.07556196
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse3.07556196
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04543198
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.77792621
10DROSHA_22980978_ChIP-Seq_HELA_Human2.74142285
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71991355
12* EED_16625203_ChIP-ChIP_MESCs_Mouse2.66257270
13REST_21632747_ChIP-Seq_MESCs_Mouse2.65870568
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.62722909
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60687982
16* EZH2_27294783_Chip-Seq_ESCs_Mouse2.59288098
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52323274
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.51867067
19* EZH2_27304074_Chip-Seq_ESCs_Mouse2.49748123
20GBX2_23144817_ChIP-Seq_PC3_Human2.43183599
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41839904
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.39728247
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.36751133
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27202199
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17247975
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.10769423
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10249377
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98657250
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.94068371
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.92753919
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80828625
32ZNF274_21170338_ChIP-Seq_K562_Hela1.68501990
33* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.67563435
34TAF15_26573619_Chip-Seq_HEK293_Human1.56221337
35* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48030364
36* RING1B_27294783_Chip-Seq_ESCs_Mouse1.47410770
37KDM2B_26808549_Chip-Seq_K562_Human1.47130425
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46577058
39SMAD4_21799915_ChIP-Seq_A2780_Human1.40120595
40* CBX2_27304074_Chip-Seq_ESCs_Mouse1.38137695
41* RING1B_27294783_Chip-Seq_NPCs_Mouse1.36640692
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36021271
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33439677
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32837448
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32054985
46* AR_19668381_ChIP-Seq_PC3_Human1.31070319
47RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26750294
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25563385
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24872231
50* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24775890
51* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24596898
52AR_21572438_ChIP-Seq_LNCaP_Human1.23608160
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22113493
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20759633
55* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17823173
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17380323
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.16397226
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13837472
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12239833
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11977281
61* TP53_20018659_ChIP-ChIP_R1E_Mouse1.11685590
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10806987
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10806987
64* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09797108
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09039418
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07797123
67STAT3_23295773_ChIP-Seq_U87_Human1.06709451
68* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06636576
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05381966
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05243331
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04956206
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04719214
73TP53_16413492_ChIP-PET_HCT116_Human1.02654808
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02402484
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01525222
76ISL1_27105846_Chip-Seq_CPCs_Mouse1.01517885
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00662544
78* RNF2_27304074_Chip-Seq_NSC_Mouse1.00507905
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99527244
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98887035
81* AR_25329375_ChIP-Seq_VCAP_Human0.98098050
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97024132
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96964176
84SMAD3_21741376_ChIP-Seq_ESCs_Human0.96675912
85SMAD3_21741376_ChIP-Seq_EPCs_Human0.95540800
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95176167
87TCF4_23295773_ChIP-Seq_U87_Human0.95110916
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94720511
89ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94710761
90SOX9_26525672_Chip-Seq_HEART_Mouse0.93996145
91PIAS1_25552417_ChIP-Seq_VCAP_Human0.92592912
92IGF1R_20145208_ChIP-Seq_DFB_Human0.92552606
93SMAD_19615063_ChIP-ChIP_OVARY_Human0.92450013
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92204588
95NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91559184
96* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91486764
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91479440
98CTCF_27219007_Chip-Seq_Bcells_Human0.91228830
99P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90294902
100SMAD4_21741376_ChIP-Seq_EPCs_Human0.90061581
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.88800468
102TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88742967
103RUNX2_22187159_ChIP-Seq_PCA_Human0.87892085
104CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87593646
105TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87488009
106* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87447125
107P300_19829295_ChIP-Seq_ESCs_Human0.86910132
108TET1_21490601_ChIP-Seq_MESCs_Mouse0.86427066
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84924579
110POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84106445
111RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83764334
112KDM2B_26808549_Chip-Seq_JURKAT_Human0.83572228
113CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83437788
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83312387
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82388383
116TBX3_20139965_ChIP-Seq_MESCs_Mouse0.82168117
117TBX3_20139965_ChIP-Seq_ESCs_Mouse0.82002167
118ZFP57_27257070_Chip-Seq_ESCs_Mouse0.81437686
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80922827
120KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80904347
121* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80539184

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.05004719
2MP0009046_muscle_twitch4.97149015
3MP0003635_abnormal_synaptic_transmissio3.92791211
4MP0005423_abnormal_somatic_nervous3.70516007
5MP0008569_lethality_at_weaning3.50904945
6MP0009745_abnormal_behavioral_response3.12769507
7MP0002064_seizures3.06639556
8MP0003880_abnormal_central_pattern3.06046957
9MP0002272_abnormal_nervous_system2.99248497
10MP0004270_analgesia2.89507540
11MP0004145_abnormal_muscle_electrophysio2.78991154
12MP0001968_abnormal_touch/_nociception2.75259056
13MP0002063_abnormal_learning/memory/cond2.71465289
14MP0002734_abnormal_mechanical_nocicepti2.67965122
15* MP0002067_abnormal_sensory_capabilities2.67030362
16MP0002184_abnormal_innervation2.59605281
17MP0002572_abnormal_emotion/affect_behav2.51883439
18MP0001440_abnormal_grooming_behavior2.44797144
19MP0001486_abnormal_startle_reflex2.37785447
20MP0002736_abnormal_nociception_after2.31055165
21MP0004885_abnormal_endolymph2.26083594
22MP0000778_abnormal_nervous_system2.16309273
23MP0001501_abnormal_sleep_pattern2.13362738
24MP0003121_genomic_imprinting2.01646825
25MP0002735_abnormal_chemical_nociception1.92584516
26MP0002557_abnormal_social/conspecific_i1.90573916
27MP0004742_abnormal_vestibular_system1.88369860
28MP0000955_abnormal_spinal_cord1.87445698
29MP0002733_abnormal_thermal_nociception1.86821308
30MP0003123_paternal_imprinting1.80299232
31MP0001970_abnormal_pain_threshold1.73780851
32MP0005386_behavior/neurological_phenoty1.70851132
33MP0004924_abnormal_behavior1.70851132
34MP0002653_abnormal_ependyma_morphology1.60756688
35MP0003632_abnormal_nervous_system1.60085278
36MP0004858_abnormal_nervous_system1.58683004
37MP0005187_abnormal_penis_morphology1.58248255
38* MP0002066_abnormal_motor_capabilities/c1.57289850
39MP0006276_abnormal_autonomic_nervous1.52959273
40MP0003329_amyloid_beta_deposits1.51206737
41MP0001984_abnormal_olfaction1.50973179
42MP0002882_abnormal_neuron_morphology1.49983354
43MP0004811_abnormal_neuron_physiology1.48141115
44MP0000566_synostosis1.42215323
45* MP0002152_abnormal_brain_morphology1.39982133
46MP0010030_abnormal_orbit_morphology1.39245515
47MP0004147_increased_porphyrin_level1.35893613
48MP0003633_abnormal_nervous_system1.34623866
49MP0003631_nervous_system_phenotype1.31398787
50MP0001502_abnormal_circadian_rhythm1.31255552
51MP0003787_abnormal_imprinting1.28956681
52MP0000049_abnormal_middle_ear1.28156912
53MP0005377_hearing/vestibular/ear_phenot1.27631148
54MP0003878_abnormal_ear_physiology1.27631148
55MP0003690_abnormal_glial_cell1.26172020
56* MP0004142_abnormal_muscle_tone1.21934936
57MP0001299_abnormal_eye_distance/1.20926270
58MP0002909_abnormal_adrenal_gland1.14381076
59MP0005248_abnormal_Harderian_gland1.14161034
60MP0000920_abnormal_myelination1.09584615
61MP0002938_white_spotting1.09366046
62MP0008789_abnormal_olfactory_epithelium1.08866055
63MP0002249_abnormal_larynx_morphology1.07734150
64MP0001293_anophthalmia1.06585645
65MP0006072_abnormal_retinal_apoptosis1.06442236
66MP0002638_abnormal_pupillary_reflex1.04384548
67MP0000534_abnormal_ureter_morphology1.03665534
68MP0003942_abnormal_urinary_system1.02652209
69MP0004215_abnormal_myocardial_fiber1.02333688
70MP0003283_abnormal_digestive_organ1.01614315
71MP0002822_catalepsy1.01077930
72MP0003137_abnormal_impulse_conducting1.00829110
73MP0005394_taste/olfaction_phenotype0.99998589
74MP0005499_abnormal_olfactory_system0.99998589
75MP0001529_abnormal_vocalization0.99595308
76MP0004133_heterotaxia0.99394653
77MP0003879_abnormal_hair_cell0.99119562
78MP0000579_abnormal_nail_morphology0.98725235
79MP0002089_abnormal_postnatal_growth/wei0.97987390
80MP0003136_yellow_coat_color0.97809147
81MP0009379_abnormal_foot_pigmentation0.96555738
82MP0005623_abnormal_meninges_morphology0.94963884
83MP0002233_abnormal_nose_morphology0.94270387
84* MP0003861_abnormal_nervous_system0.94099964
85MP0006292_abnormal_olfactory_placode0.93282118
86MP0002229_neurodegeneration0.92496149
87MP0000569_abnormal_digit_pigmentation0.92429193
88MP0001963_abnormal_hearing_physiology0.90338096
89MP0009780_abnormal_chondrocyte_physiolo0.89742848
90MP0005167_abnormal_blood-brain_barrier0.89475418
91MP0005551_abnormal_eye_electrophysiolog0.87712895
92MP0002752_abnormal_somatic_nervous0.87648626
93MP0000751_myopathy0.87245151
94MP0002234_abnormal_pharynx_morphology0.86338376
95MP0003122_maternal_imprinting0.86210801
96MP0002116_abnormal_craniofacial_bone0.85731711
97MP0008872_abnormal_physiological_respon0.85396294
98MP0003634_abnormal_glial_cell0.85294628
99MP0001485_abnormal_pinna_reflex0.83374512
100MP0005645_abnormal_hypothalamus_physiol0.82931195
101MP0003119_abnormal_digestive_system0.81960631
102MP0001177_atelectasis0.80365629
103* MP0002081_perinatal_lethality0.78358989
104MP0004043_abnormal_pH_regulation0.77331848
105* MP0002069_abnormal_eating/drinking_beha0.74121322
106* MP0010769_abnormal_survival0.73476016
107MP0000631_abnormal_neuroendocrine_gland0.73077850
108MP0004085_abnormal_heartbeat0.72291588
109MP0005646_abnormal_pituitary_gland0.72105292
110MP0003755_abnormal_palate_morphology0.71859279
111MP0003937_abnormal_limbs/digits/tail_de0.71740360
112MP0001188_hyperpigmentation0.71631725
113MP0001905_abnormal_dopamine_level0.71053880
114MP0004484_altered_response_of0.70949828
115* MP0010768_mortality/aging0.70271062
116MP0000013_abnormal_adipose_tissue0.69440335
117* MP0002082_postnatal_lethality0.69427822
118* MP0010770_preweaning_lethality0.69427822
119MP0001943_abnormal_respiration0.68562154
120MP0000537_abnormal_urethra_morphology0.68030002
121MP0000026_abnormal_inner_ear0.63823075
122MP0005171_absent_coat_pigmentation0.59271726
123MP0005253_abnormal_eye_physiology0.57359073
124MP0003385_abnormal_body_wall0.52940581
125MP0003938_abnormal_ear_development0.51704873
126MP0004233_abnormal_muscle_weight0.51186689
127MP0008874_decreased_physiological_sensi0.49771630
128* MP0003956_abnormal_body_size0.49222670

Predicted human phenotypes

RankGene SetZ-score
1Progressive cerebellar ataxia (HP:0002073)6.74985551
2Action tremor (HP:0002345)6.61629864
3Focal motor seizures (HP:0011153)5.31420033
4Gaze-evoked nystagmus (HP:0000640)5.15997960
5Visual hallucinations (HP:0002367)5.07648799
6Focal seizures (HP:0007359)4.82302032
7Scanning speech (HP:0002168)4.72933762
8Myokymia (HP:0002411)4.46851694
9Dysdiadochokinesis (HP:0002075)4.42183861
10Hemiplegia (HP:0002301)4.41502341
11Dysmetric saccades (HP:0000641)4.31619650
12Atonic seizures (HP:0010819)4.30848325
13Impaired smooth pursuit (HP:0007772)4.23047406
14Hemiparesis (HP:0001269)4.18001906
15Febrile seizures (HP:0002373)4.08178261
16Genetic anticipation (HP:0003743)4.02035205
17Abnormality of ocular smooth pursuit (HP:0000617)4.00376339
18Broad-based gait (HP:0002136)3.97360566
19Intention tremor (HP:0002080)3.73093968
20Diplopia (HP:0000651)3.71398683
21Abnormality of binocular vision (HP:0011514)3.71398683
22Epileptic encephalopathy (HP:0200134)3.61015295
23Truncal ataxia (HP:0002078)3.58285170
24Dysmetria (HP:0001310)3.55447540
25Absence seizures (HP:0002121)3.42746476
26Tetraplegia (HP:0002445)3.23453314
27Postural tremor (HP:0002174)3.18969891
28Abnormality of the lower motor neuron (HP:0002366)3.16774092
29Neurofibrillary tangles (HP:0002185)3.05473594
30Oligodactyly (hands) (HP:0001180)2.96996568
31Poor eye contact (HP:0000817)2.96693660
32Generalized tonic-clonic seizures (HP:0002069)2.95199139
33Dialeptic seizures (HP:0011146)2.89127130
34Horizontal nystagmus (HP:0000666)2.78567387
35Status epilepticus (HP:0002133)2.76683616
36Neonatal short-limb short stature (HP:0008921)2.76118350
37Limb dystonia (HP:0002451)2.72497075
38Agitation (HP:0000713)2.71591237
39Annular pancreas (HP:0001734)2.70821146
40Neoplasm of the heart (HP:0100544)2.67972357
41Impaired social interactions (HP:0000735)2.66411461
42Abnormal social behavior (HP:0012433)2.66411461
43Depression (HP:0000716)2.65724710
44Morphological abnormality of the middle ear (HP:0008609)2.64928876
45Abnormality of the corticospinal tract (HP:0002492)2.64452529
46Trigonocephaly (HP:0000243)2.61501747
47Abnormality of saccadic eye movements (HP:0000570)2.61035687
48Sleep apnea (HP:0010535)2.59815798
49Shallow orbits (HP:0000586)2.57499386
50Polyphagia (HP:0002591)2.53154944
51Amyotrophic lateral sclerosis (HP:0007354)2.52614871
52Limb ataxia (HP:0002070)2.50941126
53Supranuclear gaze palsy (HP:0000605)2.49457892
54Turricephaly (HP:0000262)2.48586774
55Anxiety (HP:0000739)2.45719677
56Abnormal eating behavior (HP:0100738)2.42765904
57Insomnia (HP:0100785)2.42598473
58Pointed chin (HP:0000307)2.41707133
59Ventricular fibrillation (HP:0001663)2.35722873
60Septo-optic dysplasia (HP:0100842)2.32342706
61Cutaneous finger syndactyly (HP:0010554)2.30921990
62Cerebral inclusion bodies (HP:0100314)2.28134102
63Stereotypic behavior (HP:0000733)2.27612704
64Lower limb asymmetry (HP:0100559)2.26394899
65Impaired vibration sensation in the lower limbs (HP:0002166)2.26164489
66Gait ataxia (HP:0002066)2.25096778
67Aqueductal stenosis (HP:0002410)2.24471941
68Excessive salivation (HP:0003781)2.23309868
69Drooling (HP:0002307)2.23309868
70Megalencephaly (HP:0001355)2.18341837
71Papilledema (HP:0001085)2.16793346
72Vertebral arch anomaly (HP:0008438)2.14211239
73Morphological abnormality of the pyramidal tract (HP:0002062)2.14072705
74Mild short stature (HP:0003502)2.12918434
75Mutism (HP:0002300)2.12106803
76Vitreoretinal degeneration (HP:0000655)2.11096675
77Hyperacusis (HP:0010780)2.09648607
78Hypoplastic nipples (HP:0002557)2.09528459
79Cutaneous syndactyly (HP:0012725)2.08903068
80Wide anterior fontanel (HP:0000260)2.07188897
81Split foot (HP:0001839)2.06910833
82Spastic gait (HP:0002064)2.04167971
83Calcaneovalgus deformity (HP:0001848)2.02551451
84Neuronal loss in central nervous system (HP:0002529)2.02080886
85Oligodactyly (HP:0012165)2.01428357
86Elfin facies (HP:0004428)1.99186190
87Obstructive sleep apnea (HP:0002870)1.98773062
88Overriding aorta (HP:0002623)1.98376424
89Broad metatarsal (HP:0001783)1.97793306
90Gait imbalance (HP:0002141)1.94295636
91Hyperventilation (HP:0002883)1.91834259
92Abnormality of the ischium (HP:0003174)1.91519943
93Torticollis (HP:0000473)1.90926373
94Coronal craniosynostosis (HP:0004440)1.90067310
95Postural instability (HP:0002172)1.89559416
96Fetal akinesia sequence (HP:0001989)1.89536877
97High anterior hairline (HP:0009890)1.89184766
98Bundle branch block (HP:0011710)1.88614887
99Narrow nasal bridge (HP:0000446)1.87771988
100Spinal canal stenosis (HP:0003416)1.87475356
101Ankle clonus (HP:0011448)1.86722075
102Deformed tarsal bones (HP:0008119)1.86180797
103Abnormality of the diencephalon (HP:0010662)1.85027016
104Bronchomalacia (HP:0002780)1.84751694
105Myotonia (HP:0002486)1.83607426
106Genu recurvatum (HP:0002816)1.83394558
107Renovascular hypertension (HP:0100817)1.82863865
108Absent speech (HP:0001344)1.80481707
109Urinary bladder sphincter dysfunction (HP:0002839)1.80192596
110Psychosis (HP:0000709)1.79182867
111Anteriorly placed anus (HP:0001545)1.79042332
112Incomplete penetrance (HP:0003829)1.78896178
113Slow progression (HP:0003677)1.77005806
114Confusion (HP:0001289)1.76276216
115Specific learning disability (HP:0001328)1.75956787
116Abnormality of the 4th metacarpal (HP:0010012)1.75937669
117Pheochromocytoma (HP:0002666)1.75213834
118Optic nerve hypoplasia (HP:0000609)1.74744788
119Inappropriate behavior (HP:0000719)1.72954915
120Short 4th metacarpal (HP:0010044)1.72633466
121Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72633466
122Omphalocele (HP:0001539)1.72192025
123Hypoplasia of the brainstem (HP:0002365)1.71279160
124Aplasia/Hypoplasia of the brainstem (HP:0007362)1.71279160
125EEG with generalized epileptiform discharges (HP:0011198)1.70906782
126Bowel diverticulosis (HP:0005222)1.70536245
127Exotropia (HP:0000577)1.69029341
128Amblyopia (HP:0000646)1.68345785
129Epileptiform EEG discharges (HP:0011182)1.67432533
130Atrophic scars (HP:0001075)1.67319161
131Sacral dimple (HP:0000960)1.66379546
132Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66017131
133Degeneration of the lateral corticospinal tracts (HP:0002314)1.66017131
134Hypoplasia of the corpus callosum (HP:0002079)1.65955481
135Hypsarrhythmia (HP:0002521)1.65484264
136Sporadic (HP:0003745)1.65436645
137Aplasia involving bones of the upper limbs (HP:0009823)1.63745026
138Aplasia of the phalanges of the hand (HP:0009802)1.63745026
139Aplasia involving bones of the extremities (HP:0009825)1.63745026
140Deep palmar crease (HP:0006191)1.63419050
141Spastic tetraplegia (HP:0002510)1.61826485
142Abnormality of dentin (HP:0010299)1.61470705
143Failure to thrive in infancy (HP:0001531)1.61402549
144Absent septum pellucidum (HP:0001331)1.60605950

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMKK23.67570996
2NTRK33.54417202
3RIPK13.16695248
4MARK12.97795978
5MAP3K42.80748513
6EPHA42.49825949
7CAMKK12.49479598
8NTRK22.48213553
9WNK12.46376587
10TNIK2.44132174
11MAP3K92.34903364
12MINK12.33590494
13PAK62.20065054
14CDK192.07765085
15MAP2K71.96539928
16STK381.90513247
17DAPK21.87721808
18PNCK1.84408981
19MAP2K41.82758255
20SIK21.81862676
21PRPF4B1.69980835
22LATS21.62002973
23UHMK11.49888068
24TYRO31.48753871
25DYRK21.48039859
26MAPK131.47353303
27CASK1.46591041
28MOS1.44124081
29PRKCG1.43955868
30RIPK41.41648403
31ALK1.39159597
32SGK2231.37527463
33SGK4941.37527463
34STK111.36718790
35SGK21.30197787
36CDK51.18201966
37KSR11.15469022
38OXSR11.14534979
39SGK31.14012798
40PTK61.13082575
41PRKCH1.12502725
42CDC42BPA1.12353128
43CAMK1G1.11466671
44CDK151.08385801
45CDK181.04483170
46ERBB31.03928759
47CAMK41.02376246
48CAMK11.00277012
49DYRK1A0.98068110
50CDK11A0.96116425
51ROCK20.93811141
52CDK140.91508139
53ARAF0.91010989
54NTRK10.90704691
55HIPK20.85982724
56PHKG10.85880140
57PHKG20.85880140
58IRAK20.84725137
59PINK10.84599673
60GRK50.81239282
61CAMK2G0.81033174
62CAMK2B0.76293523
63BRD40.76106289
64PLK20.74139220
65PRKG10.73891247
66CAMK2A0.71885067
67DYRK1B0.70752541
68MAPKAPK50.70540984
69SGK10.70309567
70TRIM280.69922089
71ICK0.69886857
72WNK40.69622401
73MAP3K120.67439504
74MKNK20.65706105
75RET0.62951222
76MARK20.62607099
77FGFR20.62454594
78RPS6KA30.61638958
79PDGFRA0.59546336
80CAMK2D0.58813194
81PTK20.58234445
82NEK60.57797709
83FYN0.56506587
84PRKDC0.56222419
85RPS6KA40.56143719
86STK390.56128760
87NEK20.55324757
88ERBB20.54439846
89EPHB20.54316836
90FES0.53979264
91CSNK1G20.53510709
92MAPK100.50770447
93RPS6KA20.50453482
94DAPK10.48173495
95MAPK90.47388916
96WNK30.47279370
97BCR0.47056193
98LMTK20.46833293
99MAPK80.45477381
100PRKCZ0.45009111
101KSR20.43831744
102ROCK10.43740295
103TNK20.43054665
104PKN10.42785139
105PRKD30.42781453
106SRC0.41730950
107MAPK150.41449540
108CSNK1A1L0.40962873
109PAK30.40631400
110PRKACA0.40190014
111RPS6KB10.39961035
112PDK10.39343578
113PRKACB0.38660886
114PRKCB0.38618829
115FGFR10.38432446
116GSK3B0.37964971
117EPHA30.37011435
118CSNK1E0.36835245
119PKN20.34006015
120DMPK0.32354852
121BRAF0.30114635
122CSNK1D0.29171131
123PRKCE0.28823569
124LATS10.28028814

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.56823492
2Glutamatergic synapse_Homo sapiens_hsa047243.13750320
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.94180438
4GABAergic synapse_Homo sapiens_hsa047272.81228413
5Long-term potentiation_Homo sapiens_hsa047202.78184225
6Circadian entrainment_Homo sapiens_hsa047132.68041890
7Long-term depression_Homo sapiens_hsa047302.62436156
8Synaptic vesicle cycle_Homo sapiens_hsa047212.54743392
9Morphine addiction_Homo sapiens_hsa050322.49052326
10Taste transduction_Homo sapiens_hsa047422.43536876
11Salivary secretion_Homo sapiens_hsa049702.19898541
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.09877707
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07118803
14Amphetamine addiction_Homo sapiens_hsa050311.99205133
15Gastric acid secretion_Homo sapiens_hsa049711.91470381
16Dopaminergic synapse_Homo sapiens_hsa047281.85827386
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76513662
18Olfactory transduction_Homo sapiens_hsa047401.67583472
19Insulin secretion_Homo sapiens_hsa049111.67519286
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63256584
21Cholinergic synapse_Homo sapiens_hsa047251.61512290
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.60396676
23Type II diabetes mellitus_Homo sapiens_hsa049301.53087939
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.52293259
25Oxytocin signaling pathway_Homo sapiens_hsa049211.51978526
26Renin secretion_Homo sapiens_hsa049241.43324644
27Calcium signaling pathway_Homo sapiens_hsa040201.42808200
28Serotonergic synapse_Homo sapiens_hsa047261.38113422
29Gap junction_Homo sapiens_hsa045401.35525019
30cAMP signaling pathway_Homo sapiens_hsa040241.35311157
31Estrogen signaling pathway_Homo sapiens_hsa049151.34554970
32GnRH signaling pathway_Homo sapiens_hsa049121.26622770
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26208452
34Pancreatic secretion_Homo sapiens_hsa049721.22044751
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18495123
36Cocaine addiction_Homo sapiens_hsa050301.12896972
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07383358
38Thyroid hormone synthesis_Homo sapiens_hsa049181.07068518
39Axon guidance_Homo sapiens_hsa043601.05775164
40Cardiac muscle contraction_Homo sapiens_hsa042601.05285472
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05113384
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01661596
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.01478934
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01177024
45Protein digestion and absorption_Homo sapiens_hsa049740.98795268
46Hedgehog signaling pathway_Homo sapiens_hsa043400.96325569
47Nitrogen metabolism_Homo sapiens_hsa009100.94403506
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94298128
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93548756
50Melanogenesis_Homo sapiens_hsa049160.92498392
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88887642
52Phototransduction_Homo sapiens_hsa047440.85909403
53Dilated cardiomyopathy_Homo sapiens_hsa054140.81419105
54Choline metabolism in cancer_Homo sapiens_hsa052310.81258049
55Inositol phosphate metabolism_Homo sapiens_hsa005620.80589161
56Glioma_Homo sapiens_hsa052140.80063363
57Bile secretion_Homo sapiens_hsa049760.78949823
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.78619356
59ErbB signaling pathway_Homo sapiens_hsa040120.78003697
60Oocyte meiosis_Homo sapiens_hsa041140.77799356
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76824132
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76237618
63Notch signaling pathway_Homo sapiens_hsa043300.74879875
64MAPK signaling pathway_Homo sapiens_hsa040100.72799781
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71272159
66Prion diseases_Homo sapiens_hsa050200.68759316
67Basal cell carcinoma_Homo sapiens_hsa052170.67552306
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66368753
69Adherens junction_Homo sapiens_hsa045200.64986382
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63791463
71Circadian rhythm_Homo sapiens_hsa047100.63594358
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63570869
73Dorso-ventral axis formation_Homo sapiens_hsa043200.61970830
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.61832629
75ECM-receptor interaction_Homo sapiens_hsa045120.61748822
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61637122
77Wnt signaling pathway_Homo sapiens_hsa043100.58576431
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57589812
79mTOR signaling pathway_Homo sapiens_hsa041500.56786438
80Endometrial cancer_Homo sapiens_hsa052130.52486269
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52381953
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48571996
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47867610
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47747928
85Mineral absorption_Homo sapiens_hsa049780.47518403
86Rap1 signaling pathway_Homo sapiens_hsa040150.47098297
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.46576930
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43788351
89Proteoglycans in cancer_Homo sapiens_hsa052050.43221161
90VEGF signaling pathway_Homo sapiens_hsa043700.43018478
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42556802
92Colorectal cancer_Homo sapiens_hsa052100.41937158
93Collecting duct acid secretion_Homo sapiens_hsa049660.41492134
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40028634
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39520658
96Steroid biosynthesis_Homo sapiens_hsa001000.39428915
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.39213063
98AMPK signaling pathway_Homo sapiens_hsa041520.39163309
99Renal cell carcinoma_Homo sapiens_hsa052110.38499447
100Hippo signaling pathway_Homo sapiens_hsa043900.37133010
101Alcoholism_Homo sapiens_hsa050340.35644415
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35347693
103Non-small cell lung cancer_Homo sapiens_hsa052230.35056808
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34503538
105Ras signaling pathway_Homo sapiens_hsa040140.34051143
106Pathways in cancer_Homo sapiens_hsa052000.33362516
107Chemokine signaling pathway_Homo sapiens_hsa040620.33194348
108Endocytosis_Homo sapiens_hsa041440.32781486
109Butanoate metabolism_Homo sapiens_hsa006500.32336269
110Platelet activation_Homo sapiens_hsa046110.30557647
111Tight junction_Homo sapiens_hsa045300.29589297
112Glucagon signaling pathway_Homo sapiens_hsa049220.29354035
113Fatty acid biosynthesis_Homo sapiens_hsa000610.28518566
114Ovarian steroidogenesis_Homo sapiens_hsa049130.28404658
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26616664
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24861812
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23927698

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