ZIC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Expansion of an alanine repeat in the C-terminus of the encoded protein and other mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gamma-aminobutyric acid transport (GO:0015812)5.84791733
2cerebellar granule cell differentiation (GO:0021707)5.55356544
3cerebellar Purkinje cell differentiation (GO:0021702)5.06976744
4chromatin remodeling at centromere (GO:0031055)4.74829356
5CENP-A containing nucleosome assembly (GO:0034080)4.47767306
6cell differentiation in hindbrain (GO:0021533)4.40513301
7layer formation in cerebral cortex (GO:0021819)4.32618925
8locomotory exploration behavior (GO:0035641)4.20149796
9histone exchange (GO:0043486)4.18853896
10response to pheromone (GO:0019236)4.17520886
11potassium ion import (GO:0010107)4.10231090
12establishment of integrated proviral latency (GO:0075713)4.07840907
13G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.99649068
14negative regulation of translation, ncRNA-mediated (GO:0040033)3.94949144
15regulation of translation, ncRNA-mediated (GO:0045974)3.94949144
16negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.94949144
17cellular potassium ion homeostasis (GO:0030007)3.93318501
18sodium ion export (GO:0071436)3.91316442
19synaptic vesicle maturation (GO:0016188)3.91309700
20establishment of planar polarity (GO:0001736)3.88019539
21establishment of tissue polarity (GO:0007164)3.88019539
22heterochromatin organization (GO:0070828)3.83962551
23neuronal action potential propagation (GO:0019227)3.79784313
24DNA replication-independent nucleosome organization (GO:0034724)3.76952321
25DNA replication-independent nucleosome assembly (GO:0006336)3.76952321
26negative regulation of hormone biosynthetic process (GO:0032353)3.73139106
27negative regulation of hormone metabolic process (GO:0032351)3.73139106
28DNA replication checkpoint (GO:0000076)3.66578813
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.62210471
30positive regulation of synapse maturation (GO:0090129)3.58779181
31DNA ligation (GO:0006266)3.54822635
32regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.52309044
33cell migration in hindbrain (GO:0021535)3.51378797
34neurotransmitter secretion (GO:0007269)3.48957066
35regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.47895227
36regulation of mitotic spindle checkpoint (GO:1903504)3.47895227
37negative regulation of DNA-dependent DNA replication (GO:2000104)3.45267677
38protein localization to kinetochore (GO:0034501)3.44553725
39DNA double-strand break processing (GO:0000729)3.44413262
40head development (GO:0060322)3.43985859
41positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.41609935
42glutamate receptor signaling pathway (GO:0007215)3.40915645
43ionotropic glutamate receptor signaling pathway (GO:0035235)3.37991749
44mitotic metaphase plate congression (GO:0007080)3.34929126
45lymph vessel development (GO:0001945)3.34653498
46neuromuscular process controlling balance (GO:0050885)3.34246833
47negative regulation of catenin import into nucleus (GO:0035414)3.33906341
48vocalization behavior (GO:0071625)3.32399050
49regulation of nuclear cell cycle DNA replication (GO:0033262)3.31077586
50spindle checkpoint (GO:0031577)3.29581559
51regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.29562968
52spinal cord development (GO:0021510)3.28085702
53positive regulation of dendritic spine morphogenesis (GO:0061003)3.27413306
54L-serine metabolic process (GO:0006563)3.24410137
55negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22960820
56negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.22960820
57negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22960820
58negative regulation of mitotic sister chromatid separation (GO:2000816)3.22960820
59negative regulation of sister chromatid segregation (GO:0033046)3.22960820
60DNA replication-dependent nucleosome organization (GO:0034723)3.21483543
61DNA replication-dependent nucleosome assembly (GO:0006335)3.21483543
62negative regulation of chromosome segregation (GO:0051985)3.19342929
63dendrite morphogenesis (GO:0048813)3.18621202
64establishment of apical/basal cell polarity (GO:0035089)3.18261704
65somatic hypermutation of immunoglobulin genes (GO:0016446)3.18179959
66somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18179959
67kinetochore organization (GO:0051383)3.17588720
68mitotic spindle checkpoint (GO:0071174)3.17346888
69DNA damage response, detection of DNA damage (GO:0042769)3.17139065
70DNA strand elongation involved in DNA replication (GO:0006271)3.16705902
71metaphase plate congression (GO:0051310)3.13428018
72regulation of helicase activity (GO:0051095)3.13424986
73ATP-dependent chromatin remodeling (GO:0043044)3.13246256
74purine nucleobase biosynthetic process (GO:0009113)3.11610225
75kinetochore assembly (GO:0051382)3.10381527
76synaptic transmission, glutamatergic (GO:0035249)3.09280581
77regulation of short-term neuronal synaptic plasticity (GO:0048172)3.09131357
78establishment of nucleus localization (GO:0040023)3.07218426
79presynaptic membrane assembly (GO:0097105)3.06854449
80negative regulation of DNA recombination (GO:0045910)3.05035501
81IMP biosynthetic process (GO:0006188)3.03474508
82cell fate commitment involved in formation of primary germ layer (GO:0060795)3.01781914
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99734066
84gamma-aminobutyric acid signaling pathway (GO:0007214)2.99419580
85DNA strand elongation (GO:0022616)2.98986368
86C4-dicarboxylate transport (GO:0015740)2.95889226
87replication fork processing (GO:0031297)2.94848972
88establishment of viral latency (GO:0019043)2.92439607
89dendritic spine morphogenesis (GO:0060997)2.91908034
90establishment of protein localization to mitochondrial membrane (GO:0090151)2.89801600
91neuromuscular process controlling posture (GO:0050884)2.88339032
92regulation of mitotic sister chromatid separation (GO:0010965)2.88236766
93regulation of mitotic sister chromatid segregation (GO:0033047)2.88236766
94regulation of sister chromatid segregation (GO:0033045)2.88236766
95regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88189687
96regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88189687
97nucleobase biosynthetic process (GO:0046112)2.87219850
98neuronal stem cell maintenance (GO:0097150)2.86875573
99proline transport (GO:0015824)2.86269282
100regulation of posttranscriptional gene silencing (GO:0060147)2.85518931
101regulation of gene silencing by miRNA (GO:0060964)2.85518931
102regulation of gene silencing by RNA (GO:0060966)2.85518931
103mitotic spindle assembly checkpoint (GO:0007094)2.84130056
104ventricular system development (GO:0021591)2.84015006
105telomere maintenance via semi-conservative replication (GO:0032201)2.83000354
106synaptic vesicle endocytosis (GO:0048488)2.82979762
107negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.82913350
108pre-miRNA processing (GO:0031054)2.82716328
109mitotic sister chromatid segregation (GO:0000070)2.81954695
110regulation of chromosome segregation (GO:0051983)2.81056596
111cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.80851870
112lateral sprouting from an epithelium (GO:0060601)2.80725397
113mitotic sister chromatid cohesion (GO:0007064)2.78084024
114presynaptic membrane organization (GO:0097090)2.77936721
115spindle assembly checkpoint (GO:0071173)2.77601703
116negative regulation of mitosis (GO:0045839)2.77231682
117establishment or maintenance of monopolar cell polarity (GO:0061339)2.76722941
118establishment of monopolar cell polarity (GO:0061162)2.76722941
119neurotransmitter transport (GO:0006836)2.76676983
120mating behavior (GO:0007617)2.76400923
121transmission of nerve impulse (GO:0019226)2.74446074
122regulation of neuron migration (GO:2001222)2.73802799
123anterior/posterior axis specification (GO:0009948)2.71897326
124cell communication by electrical coupling (GO:0010644)2.71888865
125sister chromatid segregation (GO:0000819)2.70923778
126protein neddylation (GO:0045116)2.70862009
127long-term memory (GO:0007616)2.70727021
128anterior/posterior axis specification, embryo (GO:0008595)2.70190089
129DNA strand renaturation (GO:0000733)2.69658168
130non-recombinational repair (GO:0000726)2.68766196
131double-strand break repair via nonhomologous end joining (GO:0006303)2.68766196
132regulation of respiratory system process (GO:0044065)2.68511992
133central nervous system myelination (GO:0022010)2.67667270
134axon ensheathment in central nervous system (GO:0032291)2.67667270
135regulation of synapse maturation (GO:0090128)2.67639541
136dorsal/ventral axis specification (GO:0009950)2.67102883
137lung-associated mesenchyme development (GO:0060484)2.65926020
138chromatin assembly or disassembly (GO:0006333)2.65631552
139membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65045779
140regulation of neurotransmitter levels (GO:0001505)2.64785169
141regulation of non-canonical Wnt signaling pathway (GO:2000050)2.64448053
142synaptic vesicle exocytosis (GO:0016079)2.63343437
143kidney morphogenesis (GO:0060993)2.63129289
144telomere maintenance via telomerase (GO:0007004)2.62949446
145paraxial mesoderm development (GO:0048339)2.62476092
146IMP metabolic process (GO:0046040)2.61500257
147cochlea morphogenesis (GO:0090103)2.60823186
148regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.58566447
149regulation of centriole replication (GO:0046599)2.57875961
150atrial cardiac muscle cell action potential (GO:0086014)2.56688622
151convergent extension (GO:0060026)2.56254349
152exploration behavior (GO:0035640)2.56134116
153cell migration involved in gastrulation (GO:0042074)2.55569826
154maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55347766
155somite rostral/caudal axis specification (GO:0032525)2.55103927
156otic vesicle formation (GO:0030916)2.55092117
157regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.55014495
158neuron-neuron synaptic transmission (GO:0007270)2.54963493
159establishment of chromosome localization (GO:0051303)2.54854991
160adult walking behavior (GO:0007628)2.54654673
161glutamate secretion (GO:0014047)2.54643230
162protein localization to chromosome, centromeric region (GO:0071459)2.53666294
163negative regulation of telomerase activity (GO:0051974)2.53196480
164DNA topological change (GO:0006265)2.52903168
165regulation of telomere maintenance via telomerase (GO:0032210)2.52902373
166regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.51212296
167response to X-ray (GO:0010165)2.50570257
168negative regulation of Ras GTPase activity (GO:0034261)2.50522168
169polarized epithelial cell differentiation (GO:0030859)2.49945473
170chaperone-mediated protein transport (GO:0072321)2.49802748
171establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.49756827
172regulation of mesoderm development (GO:2000380)2.49691524
173exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49006822
174positive regulation of synapse assembly (GO:0051965)2.48100875
175mitotic recombination (GO:0006312)2.48090922
176negative regulation of mRNA processing (GO:0050686)2.47727733
177neuromuscular junction development (GO:0007528)2.46652177
178regulation of cell fate specification (GO:0042659)2.45237635
179cytoskeletal anchoring at plasma membrane (GO:0007016)2.45222063
180regulation of respiratory gaseous exchange (GO:0043576)2.45181316
181regulation of dendritic spine morphogenesis (GO:0061001)2.45052744
182potassium ion homeostasis (GO:0055075)2.44680554
183epoxygenase P450 pathway (GO:0019373)2.44652784
184nuclear pore complex assembly (GO:0051292)2.44242196
185positive regulation of dendritic spine development (GO:0060999)2.44038730
186mitotic G2/M transition checkpoint (GO:0044818)2.43808623
187regulation of timing of cell differentiation (GO:0048505)2.43776821
188regulation of glutamate receptor signaling pathway (GO:1900449)2.43166138
189negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.42972492
190negative regulation of nuclear division (GO:0051784)2.42235363
191protein localization to synapse (GO:0035418)2.41727283
192embryonic camera-type eye morphogenesis (GO:0048596)2.41645827
193acidic amino acid transport (GO:0015800)2.41276934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.55045397
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.77907448
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62111853
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.61949212
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.61949212
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.61949212
7EZH2_22144423_ChIP-Seq_EOC_Human3.28479034
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.07284916
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.04794129
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01504740
11* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.75973829
12* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.68974992
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.66987800
14* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.60896478
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60680411
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.57032004
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.47669633
18* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47107762
19* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44696831
20* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44696831
21ERG_21242973_ChIP-ChIP_JURKAT_Human2.39886317
22* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.39795956
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.38577339
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.34664694
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34108836
26* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.32971221
27ZFP281_18757296_ChIP-ChIP_E14_Mouse2.31645788
28MYC_18555785_ChIP-Seq_MESCs_Mouse2.31192401
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.20985255
30* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.17126649
31TP63_19390658_ChIP-ChIP_HaCaT_Human2.15461874
32* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14399936
33RBPJ_22232070_ChIP-Seq_NCS_Mouse2.13619114
34GABP_17652178_ChIP-ChIP_JURKAT_Human2.12459835
35* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.10228416
36EWS_26573619_Chip-Seq_HEK293_Human2.09810014
37* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09318846
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.09070360
39* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.07923617
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.06690613
41* RING1B_27294783_Chip-Seq_NPCs_Mouse2.04259100
42* RNF2_27304074_Chip-Seq_ESCs_Mouse2.02612963
43* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01329837
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00553095
45* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.98573560
46POU5F1_16518401_ChIP-PET_MESCs_Mouse1.94795171
47* NANOG_16153702_ChIP-ChIP_HESCs_Human1.93935664
48* EZH2_27304074_Chip-Seq_ESCs_Mouse1.91013250
49* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.89124853
50FUS_26573619_Chip-Seq_HEK293_Human1.88231174
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87471267
52* TP53_20018659_ChIP-ChIP_R1E_Mouse1.86333064
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85682204
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84044928
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83284300
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83018628
57* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82683104
58ZNF274_21170338_ChIP-Seq_K562_Hela1.78196719
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74306898
60* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73019773
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71702692
62* EZH2_27294783_Chip-Seq_ESCs_Mouse1.71578213
63VDR_22108803_ChIP-Seq_LS180_Human1.71425902
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.70790268
65* KDM2B_26808549_Chip-Seq_K562_Human1.69004787
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68744544
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.67341294
68TAF15_26573619_Chip-Seq_HEK293_Human1.66755525
69AR_21909140_ChIP-Seq_LNCAP_Human1.66531349
70* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65973081
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.65389013
72REST_21632747_ChIP-Seq_MESCs_Mouse1.65330031
73* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.63932671
74ELK1_19687146_ChIP-ChIP_HELA_Human1.62738128
75* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61927456
76* RING1B_27294783_Chip-Seq_ESCs_Mouse1.61766317
77* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60827094
78* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60113943
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59774323
80* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59327792
81* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58601889
82P300_19829295_ChIP-Seq_ESCs_Human1.53806393
83* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.53277746
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52226779
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.51099483
86* MYC_18940864_ChIP-ChIP_HL60_Human1.50765886
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47848660
88TBX3_20139965_ChIP-Seq_MESCs_Mouse1.46119694
89TBX3_20139965_ChIP-Seq_ESCs_Mouse1.46106040
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.43014499
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42491101
92* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41729097
93PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.41537194
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40386085
95RARB_27405468_Chip-Seq_BRAIN_Mouse1.40232554
96DROSHA_22980978_ChIP-Seq_HELA_Human1.39339462
97TTF2_22483619_ChIP-Seq_HELA_Human1.35538893
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34093995
99* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33081797
100* SOX2_16153702_ChIP-ChIP_HESCs_Human1.31682838
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.31600758
102ETS1_20019798_ChIP-Seq_JURKAT_Human1.31429983
103MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30630711
104* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30595487
105* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30367596
106* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30259818
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29652618
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.28825687
109NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28620094
110THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24627621
111MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23598169
112* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.23569631
113RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23124245
114* RNF2_27304074_Chip-Seq_NSC_Mouse1.22397727
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20287793
116* KDM2B_26808549_Chip-Seq_JURKAT_Human1.19640342
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19566084
118JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16619458
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16145903
120STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15319581
121CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14822301
122POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14598272
123FOXP3_21729870_ChIP-Seq_TREG_Human1.14561158
124CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14318162
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13430417
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13430417
127E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13352228
128SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11687308
129* NANOG_16518401_ChIP-PET_MESCs_Mouse1.10929356
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10699324
131ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10363782
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09895924
133IGF1R_20145208_ChIP-Seq_DFB_Human1.09847205
134* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.09717099
135* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09378489
136* CBX2_27304074_Chip-Seq_ESCs_Mouse1.09140811
137HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08236758
138CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07977982
139OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07934755
140PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07640576
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06969496
142DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06490572
143DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06068668
144POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05207795
145XRN2_22483619_ChIP-Seq_HELA_Human1.04726730
146WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02492358
147DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01184044
148FLI1_27457419_Chip-Seq_LIVER_Mouse1.00909607
149ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00888645
150ISL1_27105846_Chip-Seq_CPCs_Mouse0.99432787
151* KDM2B_26808549_Chip-Seq_DND41_Human0.99351376
152FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99050854
153IRF1_19129219_ChIP-ChIP_H3396_Human0.98739762
154SMAD3_21741376_ChIP-Seq_EPCs_Human0.98714937
155VDR_23849224_ChIP-Seq_CD4+_Human0.98206690
156* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97376767
157SOX9_26525672_Chip-Seq_HEART_Mouse0.97020181
158* AR_19668381_ChIP-Seq_PC3_Human0.96383282
159FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95188758
160* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94597167
161TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93636748
162NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93560320
163* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93220085
164ZNF263_19887448_ChIP-Seq_K562_Human0.93206655
165FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93160209
166GBX2_23144817_ChIP-Seq_PC3_Human0.91348109
167LXR_22292898_ChIP-Seq_THP-1_Human0.90574546
168* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89026118
169* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88949455
170KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88113154
171TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87853045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009046_muscle_twitch3.30151695
2MP0005423_abnormal_somatic_nervous3.22048793
3MP0004859_abnormal_synaptic_plasticity3.05820342
4MP0003693_abnormal_embryo_hatching2.73287965
5MP0010094_abnormal_chromosome_stability2.66933399
6MP0005623_abnormal_meninges_morphology2.66175391
7MP0008877_abnormal_DNA_methylation2.56304743
8* MP0003635_abnormal_synaptic_transmissio2.50455751
9MP0008058_abnormal_DNA_repair2.42399034
10MP0004270_analgesia2.19348881
11MP0003111_abnormal_nucleus_morphology2.19063278
12MP0004957_abnormal_blastocyst_morpholog2.18687674
13MP0003890_abnormal_embryonic-extraembry2.18493505
14MP0003941_abnormal_skin_development2.17546265
15MP0001188_hyperpigmentation2.12935541
16MP0005171_absent_coat_pigmentation2.09459723
17MP0008932_abnormal_embryonic_tissue2.08328500
18MP0008569_lethality_at_weaning2.08195377
19MP0003283_abnormal_digestive_organ2.07370807
20MP0000566_synostosis2.02781772
21MP0003122_maternal_imprinting2.01877537
22MP0006072_abnormal_retinal_apoptosis2.00246929
23MP0002064_seizures1.95554689
24MP0000778_abnormal_nervous_system1.94962258
25MP0003937_abnormal_limbs/digits/tail_de1.93215010
26MP0003880_abnormal_central_pattern1.88059124
27MP0004145_abnormal_muscle_electrophysio1.85977167
28MP0008057_abnormal_DNA_replication1.85028969
29MP0002249_abnormal_larynx_morphology1.83187742
30MP0002272_abnormal_nervous_system1.81764458
31MP0009745_abnormal_behavioral_response1.76345309
32MP0004142_abnormal_muscle_tone1.75198651
33MP0004133_heterotaxia1.75163978
34MP0003077_abnormal_cell_cycle1.74697337
35MP0002067_abnormal_sensory_capabilities1.74696397
36MP0004858_abnormal_nervous_system1.74610508
37MP0002063_abnormal_learning/memory/cond1.73718991
38MP0010030_abnormal_orbit_morphology1.73658338
39MP0002184_abnormal_innervation1.71672833
40MP0002572_abnormal_emotion/affect_behav1.69804448
41MP0001346_abnormal_lacrimal_gland1.68480785
42MP0004885_abnormal_endolymph1.67042697
43MP0003123_paternal_imprinting1.66277047
44MP0003385_abnormal_body_wall1.65156553
45MP0008789_abnormal_olfactory_epithelium1.65155827
46MP0002734_abnormal_mechanical_nocicepti1.64670629
47MP0002653_abnormal_ependyma_morphology1.62838484
48MP0006292_abnormal_olfactory_placode1.62188856
49MP0001440_abnormal_grooming_behavior1.60528438
50MP0003119_abnormal_digestive_system1.54802376
51MP0002254_reproductive_system_inflammat1.54754502
52MP0000579_abnormal_nail_morphology1.51807689
53* MP0000955_abnormal_spinal_cord1.51509608
54MP0008007_abnormal_cellular_replicative1.51387892
55* MP0002938_white_spotting1.50928143
56MP0009672_abnormal_birth_weight1.50521070
57MP0005167_abnormal_blood-brain_barrier1.47199070
58MP0001968_abnormal_touch/_nociception1.47015596
59MP0003567_abnormal_fetal_cardiomyocyte1.46831338
60* MP0003861_abnormal_nervous_system1.46094702
61MP0001293_anophthalmia1.45383816
62MP0002102_abnormal_ear_morphology1.44622882
63MP0000049_abnormal_middle_ear1.41026017
64MP0003718_maternal_effect1.40459789
65MP0005394_taste/olfaction_phenotype1.39581284
66MP0005499_abnormal_olfactory_system1.39581284
67MP0001529_abnormal_vocalization1.37057643
68MP0002009_preneoplasia1.36564101
69* MP0002152_abnormal_brain_morphology1.36380053
70MP0003137_abnormal_impulse_conducting1.32596650
71MP0002332_abnormal_exercise_endurance1.27410846
72MP0002751_abnormal_autonomic_nervous1.23762568
73MP0000537_abnormal_urethra_morphology1.21535159
74* MP0001486_abnormal_startle_reflex1.21233754
75MP0004272_abnormal_basement_membrane1.21043124
76MP0002733_abnormal_thermal_nociception1.20480892
77MP0005248_abnormal_Harderian_gland1.19193801
78MP0002882_abnormal_neuron_morphology1.17707838
79MP0003938_abnormal_ear_development1.13815441
80MP0002557_abnormal_social/conspecific_i1.13464368
81MP0004233_abnormal_muscle_weight1.13283431
82MP0003632_abnormal_nervous_system1.12542706
83MP0002116_abnormal_craniofacial_bone1.11473331
84MP0001984_abnormal_olfaction1.11450162
85* MP0002111_abnormal_tail_morphology1.10387433
86MP0005253_abnormal_eye_physiology1.09753067
87* MP0002066_abnormal_motor_capabilities/c1.09532159
88MP0002084_abnormal_developmental_patter1.08060897
89MP0001177_atelectasis1.07505159
90MP0005187_abnormal_penis_morphology1.07454577
91MP0002127_abnormal_cardiovascular_syste1.07051705
92MP0001970_abnormal_pain_threshold1.04665256
93MP0003755_abnormal_palate_morphology1.03727882
94MP0003935_abnormal_craniofacial_develop1.03391586
95MP0001697_abnormal_embryo_size1.02668048
96MP0004811_abnormal_neuron_physiology1.02156436
97MP0000762_abnormal_tongue_morphology1.02058405
98* MP0002085_abnormal_embryonic_tissue1.01557521
99MP0005367_renal/urinary_system_phenotyp0.99684484
100MP0000516_abnormal_urinary_system0.99684484
101MP0003136_yellow_coat_color0.99347435
102MP0005391_vision/eye_phenotype0.99124969
103MP0005386_behavior/neurological_phenoty0.98851095
104MP0004924_abnormal_behavior0.98851095
105MP0001730_embryonic_growth_arrest0.98718906
106* MP0000432_abnormal_head_morphology0.98375801
107MP0001672_abnormal_embryogenesis/_devel0.98115918
108MP0005380_embryogenesis_phenotype0.98115918
109MP0003942_abnormal_urinary_system0.97551688
110MP0003633_abnormal_nervous_system0.97162956
111MP0001299_abnormal_eye_distance/0.94414561
112MP0004215_abnormal_myocardial_fiber0.93933236
113* MP0002752_abnormal_somatic_nervous0.93441331
114MP0002081_perinatal_lethality0.92814688
115MP0001485_abnormal_pinna_reflex0.92352415
116MP0000462_abnormal_digestive_system0.91174820
117MP0005377_hearing/vestibular/ear_phenot0.91166737
118MP0003878_abnormal_ear_physiology0.91166737
119MP0003121_genomic_imprinting0.91093688
120MP0003315_abnormal_perineum_morphology0.90798493
121MP0004742_abnormal_vestibular_system0.90032951
122MP0000350_abnormal_cell_proliferation0.89244141
123MP0000534_abnormal_ureter_morphology0.88863748
124* MP0002114_abnormal_axial_skeleton0.88668233
125MP0003631_nervous_system_phenotype0.88520746
126MP0009379_abnormal_foot_pigmentation0.88448349
127MP0000631_abnormal_neuroendocrine_gland0.88170615
128MP0000647_abnormal_sebaceous_gland0.87836873
129MP0001286_abnormal_eye_development0.86643891
130MP0009703_decreased_birth_body0.86554278
131MP0002736_abnormal_nociception_after0.86410434
132MP0002092_abnormal_eye_morphology0.86172592
133MP0002697_abnormal_eye_size0.85589416
134MP0009053_abnormal_anal_canal0.85580868
135MP0002210_abnormal_sex_determination0.84666185
136MP0004197_abnormal_fetal_growth/weight/0.82789881
137MP0002282_abnormal_trachea_morphology0.81985659
138MP0002234_abnormal_pharynx_morphology0.81692356
139MP0002233_abnormal_nose_morphology0.81620732
140MP0001501_abnormal_sleep_pattern0.81136843
141MP0000428_abnormal_craniofacial_morphol0.80940470
142MP0001943_abnormal_respiration0.80608346
143MP0001879_abnormal_lymphatic_vessel0.79800960
144MP0003787_abnormal_imprinting0.79228375
145MP0006276_abnormal_autonomic_nervous0.78337420
146MP0003984_embryonic_growth_retardation0.78016712
147MP0002088_abnormal_embryonic_growth/wei0.77522512
148MP0009697_abnormal_copulation0.76093926

Predicted human phenotypes

RankGene SetZ-score
1Hemiparesis (HP:0001269)4.38452436
2Septo-optic dysplasia (HP:0100842)4.32524265
3Action tremor (HP:0002345)3.76181832
4Atonic seizures (HP:0010819)3.73642769
5Progressive cerebellar ataxia (HP:0002073)3.72092336
6Hemiplegia (HP:0002301)3.71016073
7Rib fusion (HP:0000902)3.56233258
8Colon cancer (HP:0003003)3.53760477
9Annular pancreas (HP:0001734)3.37773859
10Abnormality of the lower motor neuron (HP:0002366)3.32202769
11Abnormal lung lobation (HP:0002101)3.12505148
12Abnormality of binocular vision (HP:0011514)3.08589261
13Diplopia (HP:0000651)3.08589261
14Short humerus (HP:0005792)3.04725557
15Visual hallucinations (HP:0002367)2.94792208
16Dysdiadochokinesis (HP:0002075)2.93117817
17Absent septum pellucidum (HP:0001331)2.91718524
18Aplasia/hypoplasia of the humerus (HP:0006507)2.87527192
19Meckel diverticulum (HP:0002245)2.85547071
20Febrile seizures (HP:0002373)2.74237910
21Scanning speech (HP:0002168)2.73125764
22Abnormality of the ileum (HP:0001549)2.69275521
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.67806831
24Focal seizures (HP:0007359)2.64711545
25Abnormality of the septum pellucidum (HP:0007375)2.64568904
26Shawl scrotum (HP:0000049)2.62260490
27Epileptic encephalopathy (HP:0200134)2.59903118
28Stenosis of the external auditory canal (HP:0000402)2.58778090
29Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.58275172
30Optic nerve hypoplasia (HP:0000609)2.56426595
31Gaze-evoked nystagmus (HP:0000640)2.56159633
32Horizontal nystagmus (HP:0000666)2.55428869
33Ectopic kidney (HP:0000086)2.51855160
34Rectal fistula (HP:0100590)2.50703128
35Rectovaginal fistula (HP:0000143)2.50703128
36Chromsome breakage (HP:0040012)2.47494331
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.47438289
38Supernumerary ribs (HP:0005815)2.46951026
39Absence seizures (HP:0002121)2.44048076
40Impaired smooth pursuit (HP:0007772)2.43821977
41Focal motor seizures (HP:0011153)2.43433480
42Abnormality of chromosome stability (HP:0003220)2.42676719
43Concave nail (HP:0001598)2.42111095
44Amblyopia (HP:0000646)2.41976138
45Triphalangeal thumb (HP:0001199)2.39940606
46Anophthalmia (HP:0000528)2.37901571
47Myokymia (HP:0002411)2.37555592
48Broad-based gait (HP:0002136)2.37302958
49Abnormal number of incisors (HP:0011064)2.35946488
50Pancreatic fibrosis (HP:0100732)2.32695420
51Renal duplication (HP:0000075)2.31854108
52Rhabdomyosarcoma (HP:0002859)2.29482464
53True hermaphroditism (HP:0010459)2.29021300
54Intention tremor (HP:0002080)2.26369693
55Abnormality of ocular smooth pursuit (HP:0000617)2.26022896
56Oligodactyly (hands) (HP:0001180)2.25931818
57Intestinal fistula (HP:0100819)2.24336668
58Facial hemangioma (HP:0000329)2.21761656
59Dysmetric saccades (HP:0000641)2.21439712
60Birth length less than 3rd percentile (HP:0003561)2.20994675
61Preaxial hand polydactyly (HP:0001177)2.20935736
62Breast aplasia (HP:0100783)2.20042599
63Shallow orbits (HP:0000586)2.18556200
64Supernumerary bones of the axial skeleton (HP:0009144)2.18230105
65Anencephaly (HP:0002323)2.17753827
66Pseudobulbar signs (HP:0002200)2.17606896
67Bifid tongue (HP:0010297)2.17306970
68Aplasia/Hypoplasia of the breasts (HP:0010311)2.16557025
69Status epilepticus (HP:0002133)2.15913154
70Tetraplegia (HP:0002445)2.15835669
71Abdominal situs inversus (HP:0003363)2.15147560
72Abnormality of abdominal situs (HP:0011620)2.15147560
73Hepatoblastoma (HP:0002884)2.14712522
74Gastrointestinal atresia (HP:0002589)2.11596441
75Reticulocytopenia (HP:0001896)2.11085008
76Hypoplastic female external genitalia (HP:0012815)2.10925550
77Abnormal hair whorl (HP:0010721)2.10804565
78Cutaneous finger syndactyly (HP:0010554)2.10693300
79Amyotrophic lateral sclerosis (HP:0007354)2.09311877
80Confusion (HP:0001289)2.09152284
81Dialeptic seizures (HP:0011146)2.08652160
82Pancreatic cysts (HP:0001737)2.07835073
83Dysmetria (HP:0001310)2.07624386
84Preaxial foot polydactyly (HP:0001841)2.07048388
85Bilateral microphthalmos (HP:0007633)2.06578076
86Cortical dysplasia (HP:0002539)2.04963341
87Maternal diabetes (HP:0009800)2.04962236
88Short hallux (HP:0010109)2.03848507
89Supernumerary spleens (HP:0009799)2.01958189
90Postural tremor (HP:0002174)2.01655129
91Nephroblastoma (Wilms tumor) (HP:0002667)2.00633855
92Abnormality of the astrocytes (HP:0100707)2.00381314
93Astrocytoma (HP:0009592)2.00381314
94Ependymoma (HP:0002888)2.00049757
95Horseshoe kidney (HP:0000085)1.99831063
96Split hand (HP:0001171)1.98800371
97Intestinal atresia (HP:0011100)1.98380579
98Labial hypoplasia (HP:0000066)1.97984566
99Anteriorly placed anus (HP:0001545)1.97238736
100Abnormality of the duodenum (HP:0002246)1.96874502
101Vertebral fusion (HP:0002948)1.96642886
102Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.95972325
103Hyperglycinemia (HP:0002154)1.95153745
104Cutaneous syndactyly (HP:0012725)1.95004836
105Hypoplastic pelvis (HP:0008839)1.94902741
106Volvulus (HP:0002580)1.94892450
107Renal hypoplasia (HP:0000089)1.94564552
108Vaginal fistula (HP:0004320)1.93844475
109High anterior hairline (HP:0009890)1.92748944
110Dandy-Walker malformation (HP:0001305)1.92683577
111Narrow nasal bridge (HP:0000446)1.92313889
112Medulloblastoma (HP:0002885)1.92017223
113Increased nuchal translucency (HP:0010880)1.90648458
114Aplasia involving forearm bones (HP:0009822)1.88747922
115Absent forearm bone (HP:0003953)1.88747922
116Buphthalmos (HP:0000557)1.88309892
117Turricephaly (HP:0000262)1.88300389
118Glioma (HP:0009733)1.88297265
119Small intestinal stenosis (HP:0012848)1.88017067
120Duodenal stenosis (HP:0100867)1.88017067
121Abnormality of the labia minora (HP:0012880)1.87634214
122Hypochromic microcytic anemia (HP:0004840)1.87131732
123Embryonal renal neoplasm (HP:0011794)1.86016970
124Aqueductal stenosis (HP:0002410)1.85965751
125Abnormality of the preputium (HP:0100587)1.85644427
126Genetic anticipation (HP:0003743)1.84875867
127Aplasia/Hypoplasia of the tongue (HP:0010295)1.84534876
128Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84152707
129Sclerocornea (HP:0000647)1.83717027
130Hypoplastic nipples (HP:0002557)1.83364103
131Sloping forehead (HP:0000340)1.83215958
132Orthostatic hypotension (HP:0001278)1.83203088
133Aplasia/Hypoplasia of the hallux (HP:0008362)1.83082880
134Absent hand (HP:0004050)1.82502117
135Hyperventilation (HP:0002883)1.82440388
136Choanal stenosis (HP:0000452)1.82323331
137Macroorchidism (HP:0000053)1.81534213
138Obstructive sleep apnea (HP:0002870)1.81302775
139Neoplasm of the heart (HP:0100544)1.80885370
140Absent radius (HP:0003974)1.80287714
141Oligodactyly (HP:0012165)1.80175478
142Molar tooth sign on MRI (HP:0002419)1.79890921
143Abnormality of midbrain morphology (HP:0002418)1.79890921
144Vaginal atresia (HP:0000148)1.79146437
145Nephronophthisis (HP:0000090)1.79057795
146Genital tract atresia (HP:0001827)1.78848741
147Abnormality of cochlea (HP:0000375)1.77137410
148Hemivertebrae (HP:0002937)1.76158245
149Bladder diverticulum (HP:0000015)1.75355747
150Neoplasm of striated muscle (HP:0009728)1.74736040
151* Holoprosencephaly (HP:0001360)1.74111998
152Pointed chin (HP:0000307)1.73009358
153Broad metatarsal (HP:0001783)1.72687182
154Pendular nystagmus (HP:0012043)1.72441542
155Morphological abnormality of the pyramidal tract (HP:0002062)1.71883766
156Esophageal atresia (HP:0002032)1.71192740
157Growth hormone deficiency (HP:0000824)1.71104961
158Coronal craniosynostosis (HP:0004440)1.69954937
159Skin tags (HP:0010609)1.68952885
160Truncal ataxia (HP:0002078)1.68480222
161Abnormality of the diencephalon (HP:0010662)1.68442571
162Generalized tonic-clonic seizures (HP:0002069)1.67678633
163Hamartoma (HP:0010566)1.65918545
164Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.65690726
165Aplasia/Hypoplasia of the sternum (HP:0006714)1.64723756
166Chorioretinal coloboma (HP:0000567)1.62931975
167Methylmalonic acidemia (HP:0002912)1.62521858
168Pancreatic islet-cell hyperplasia (HP:0004510)1.60818120
169Broad thumb (HP:0011304)1.60182011
170Optic nerve coloboma (HP:0000588)1.58832125
171Renal agenesis (HP:0000104)1.58407993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.79271819
2CDC73.39371934
3WNK33.27908178
4TYRO33.23448538
5BUB13.21691698
6TSSK62.78251881
7CAMK1G2.61065622
8ICK2.56016684
9TTK2.54706770
10PLK32.47340585
11DDR22.46979775
12VRK22.45940013
13TRIM282.41418120
14SRPK12.22333661
15BMPR1B2.16357096
16PDGFRA2.11159762
17CDK122.06634380
18TAF12.06337192
19UHMK12.04360595
20NUAK12.03112427
21NTRK21.96369019
22NTRK31.92321548
23ZAK1.91795912
24AKT31.86531450
25MAP3K91.86175636
26RIPK11.83809932
27WEE11.81617405
28PLK41.80861107
29MAPK151.75926835
30ALK1.67128682
31BRD41.64431121
32BRSK21.63530269
33EPHA41.60928548
34FGR1.60114359
35PAK61.59854374
36ACVR1B1.50532886
37PLK11.48121187
38DYRK21.45694031
39LATS21.45231398
40MKNK21.42489835
41WNK11.41946619
42VRK11.40920900
43GRK51.40330028
44BMX1.38474846
45HIPK21.37958074
46PBK1.37494600
47NEK11.36982828
48SIK21.34281850
49MARK11.32398332
50MATK1.31229220
51MARK21.26848131
52PLK21.18426631
53MAP3K41.18217377
54STK161.16992085
55DYRK31.16339468
56MINK11.15551736
57CAMKK21.12855326
58PAK31.11996917
59CDC42BPA1.11782742
60ATR1.11056527
61TGFBR11.10215709
62CAMK41.08207922
63MAP4K21.05933199
64DYRK1B1.05538408
65BRSK11.05369487
66CHEK21.04757472
67FGFR11.03799713
68YES11.03312073
69STK111.02409656
70MAP3K61.00884824
71PRPF4B1.00440527
72PRKD21.00424864
73EEF2K0.98433179
74STK38L0.95416552
75PRKCG0.93559206
76DAPK20.93234059
77PASK0.93158438
78CDK150.92699676
79DAPK10.92415058
80NTRK10.91943454
81MAP2K20.91591502
82PAK20.87958005
83CDK11A0.87363011
84NME10.85339354
85CDK180.85205262
86CDK140.84424015
87STK380.82616163
88MAP2K40.81943064
89PTK20.80846344
90PTK60.80054292
91MST40.80046387
92ATM0.79624022
93EPHB20.79212359
94CDK190.78607462
95AURKB0.78078164
96CDK60.76389508
97ADRBK10.76169407
98FGFR20.75516194
99BCR0.74606755
100CHEK10.74457131
101NLK0.74289055
102CAMK10.72527401
103CSNK1G10.72265687
104ERBB40.71719414
105MKNK10.69299387
106RPS6KB20.69203406
107MAPK130.66887822
108STK30.66229931
109CAMKK10.65934044
110EIF2AK30.65253455
111CAMK1D0.65195827
112CSNK1G20.64169519
113ROCK20.64136038
114CDK70.63661787
115MAP3K100.63281218
116CASK0.62245040
117GRK10.61310958
118CSNK1E0.60491611
119ERBB30.59960918
120PDGFRB0.59738178
121GSK3A0.59605148
122MAPK100.59537388
123CDK50.59430707
124RPS6KA30.58174916
125EIF2AK10.57221188
126EIF2AK20.56477316
127PINK10.55428998
128OXSR10.55391703
129PHKG10.54516190
130PHKG20.54516190
131MTOR0.52945590
132MAPK90.52568265
133CDK20.52558319
134MAPK70.52491666
135CDK30.52202426
136CAMK2A0.52190203
137CAMK2B0.51515208
138DYRK1A0.50684350
139DMPK0.49419464
140TNIK0.48790148
141CDK10.48295102
142SGK10.48253931
143INSR0.48090367
144RPS6KA40.47784107
145GSK3B0.47734898
146CSK0.46346107
147MAPK140.45875634
148INSRR0.45665134
149NEK20.44839975
150* PRKDC0.44817403
151STK40.44504311
152PRKAA20.44453417
153RPS6KL10.43166934
154RPS6KC10.43166934
155PAK40.42565546
156TIE10.42111788
157CSNK1G30.41049319
158CSNK2A10.38158911
159STK390.37013884
160CSNK1A1L0.32304663
161PRKD30.30106823
162CSNK2A20.29416982
163BRAF0.27830409
164CDK90.27585387

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.55679313
2Mismatch repair_Homo sapiens_hsa034303.52641113
3DNA replication_Homo sapiens_hsa030303.21214185
4Non-homologous end-joining_Homo sapiens_hsa034503.16524042
5Glutamatergic synapse_Homo sapiens_hsa047242.77220140
6Homologous recombination_Homo sapiens_hsa034402.74911608
7GABAergic synapse_Homo sapiens_hsa047272.72607056
8Proteasome_Homo sapiens_hsa030502.46868334
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35913709
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35446841
11Long-term depression_Homo sapiens_hsa047302.33736786
12Fanconi anemia pathway_Homo sapiens_hsa034602.32224434
13RNA polymerase_Homo sapiens_hsa030202.29054102
14Long-term potentiation_Homo sapiens_hsa047202.22884629
15Circadian entrainment_Homo sapiens_hsa047132.15638668
16Base excision repair_Homo sapiens_hsa034102.11830008
17RNA transport_Homo sapiens_hsa030132.11393032
18Cell cycle_Homo sapiens_hsa041102.08495610
19Protein export_Homo sapiens_hsa030602.02160825
20Basal cell carcinoma_Homo sapiens_hsa052172.00898470
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00798495
22Basal transcription factors_Homo sapiens_hsa030221.94923919
23RNA degradation_Homo sapiens_hsa030181.92971296
24Morphine addiction_Homo sapiens_hsa050321.92410187
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.92025309
26Taste transduction_Homo sapiens_hsa047421.91382736
27Hippo signaling pathway_Homo sapiens_hsa043901.87860712
28Salivary secretion_Homo sapiens_hsa049701.87169464
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.82644546
30Nitrogen metabolism_Homo sapiens_hsa009101.81205828
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76499312
32Propanoate metabolism_Homo sapiens_hsa006401.71155122
33Vitamin B6 metabolism_Homo sapiens_hsa007501.70349652
34Nucleotide excision repair_Homo sapiens_hsa034201.65831356
35Gap junction_Homo sapiens_hsa045401.65649939
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63033322
37* Hedgehog signaling pathway_Homo sapiens_hsa043401.61029767
38Ribosome_Homo sapiens_hsa030101.60378659
39Steroid biosynthesis_Homo sapiens_hsa001001.58898529
40Dopaminergic synapse_Homo sapiens_hsa047281.58423687
41Amphetamine addiction_Homo sapiens_hsa050311.57744312
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55901972
43Synaptic vesicle cycle_Homo sapiens_hsa047211.55023106
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54955245
45Gastric acid secretion_Homo sapiens_hsa049711.51790630
46Estrogen signaling pathway_Homo sapiens_hsa049151.48726632
47One carbon pool by folate_Homo sapiens_hsa006701.45723156
48Melanogenesis_Homo sapiens_hsa049161.45021915
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44072881
50Wnt signaling pathway_Homo sapiens_hsa043101.42340733
51Pyruvate metabolism_Homo sapiens_hsa006201.39825178
52Parkinsons disease_Homo sapiens_hsa050121.39536320
53Oxytocin signaling pathway_Homo sapiens_hsa049211.34755911
54Oxidative phosphorylation_Homo sapiens_hsa001901.33620360
55Cholinergic synapse_Homo sapiens_hsa047251.32273996
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30858336
57mRNA surveillance pathway_Homo sapiens_hsa030151.29978720
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27603829
59Serotonergic synapse_Homo sapiens_hsa047261.27501109
60Fatty acid biosynthesis_Homo sapiens_hsa000611.26185376
61Huntingtons disease_Homo sapiens_hsa050161.26098922
62Tight junction_Homo sapiens_hsa045301.25892370
63GnRH signaling pathway_Homo sapiens_hsa049121.25393630
64Adherens junction_Homo sapiens_hsa045201.24624801
65Notch signaling pathway_Homo sapiens_hsa043301.21748551
66Calcium signaling pathway_Homo sapiens_hsa040201.21556534
67Insulin secretion_Homo sapiens_hsa049111.19608235
68cAMP signaling pathway_Homo sapiens_hsa040241.18873431
69Dorso-ventral axis formation_Homo sapiens_hsa043201.18437396
70Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18283247
71Selenocompound metabolism_Homo sapiens_hsa004501.16578905
72Choline metabolism in cancer_Homo sapiens_hsa052311.16387488
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15671112
74Renin secretion_Homo sapiens_hsa049241.15377861
75Axon guidance_Homo sapiens_hsa043601.15219852
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14598983
77Oocyte meiosis_Homo sapiens_hsa041141.14384096
78mTOR signaling pathway_Homo sapiens_hsa041501.12500926
79Phospholipase D signaling pathway_Homo sapiens_hsa040721.10753784
80Phototransduction_Homo sapiens_hsa047441.09133740
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07123003
82Cardiac muscle contraction_Homo sapiens_hsa042601.06172904
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05147979
84TGF-beta signaling pathway_Homo sapiens_hsa043501.02368233
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01339804
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01047332
87Purine metabolism_Homo sapiens_hsa002300.99206537
88Biosynthesis of amino acids_Homo sapiens_hsa012300.98690510
89Pyrimidine metabolism_Homo sapiens_hsa002400.98212789
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98164434
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97920817
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96867852
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95817693
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95547807
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95111305
96Thyroid hormone synthesis_Homo sapiens_hsa049180.94253988
97Proteoglycans in cancer_Homo sapiens_hsa052050.93387094
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88336506
99Rap1 signaling pathway_Homo sapiens_hsa040150.87068985
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86557371
101Glioma_Homo sapiens_hsa052140.84690098
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.84687048
103Lysine degradation_Homo sapiens_hsa003100.84352835
104Dilated cardiomyopathy_Homo sapiens_hsa054140.83188992
105Olfactory transduction_Homo sapiens_hsa047400.83032418
106p53 signaling pathway_Homo sapiens_hsa041150.82051206
107Fatty acid elongation_Homo sapiens_hsa000620.82010095
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81775768
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81386030
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79528146
111Cocaine addiction_Homo sapiens_hsa050300.78947459
112MicroRNAs in cancer_Homo sapiens_hsa052060.78025514
113ErbB signaling pathway_Homo sapiens_hsa040120.77848482
114Vitamin digestion and absorption_Homo sapiens_hsa049770.77538724
115Bile secretion_Homo sapiens_hsa049760.76201152
116Colorectal cancer_Homo sapiens_hsa052100.75678228
117Alzheimers disease_Homo sapiens_hsa050100.74674310
118MAPK signaling pathway_Homo sapiens_hsa040100.73818662
119Pancreatic secretion_Homo sapiens_hsa049720.72466770
120Carbon metabolism_Homo sapiens_hsa012000.72250621
121Type II diabetes mellitus_Homo sapiens_hsa049300.71779177
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71647355
123Focal adhesion_Homo sapiens_hsa045100.67244125
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.66219475
125Pathways in cancer_Homo sapiens_hsa052000.65608693
126Mineral absorption_Homo sapiens_hsa049780.65323825
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64222971
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62877360
129VEGF signaling pathway_Homo sapiens_hsa043700.62689062
130African trypanosomiasis_Homo sapiens_hsa051430.59716125
131Endometrial cancer_Homo sapiens_hsa052130.59329996
132Renal cell carcinoma_Homo sapiens_hsa052110.58784031
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57640858
134Butanoate metabolism_Homo sapiens_hsa006500.55757571
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54713098
136Melanoma_Homo sapiens_hsa052180.54629787
137Ras signaling pathway_Homo sapiens_hsa040140.53784410
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52989893
139Spliceosome_Homo sapiens_hsa030400.52648812
140Circadian rhythm_Homo sapiens_hsa047100.51021914
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49901645
142ECM-receptor interaction_Homo sapiens_hsa045120.49833831
143Arginine and proline metabolism_Homo sapiens_hsa003300.49431371
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.49059336
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48430677
146Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48357133
147Alcoholism_Homo sapiens_hsa050340.47728226
148Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47316609
149Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47065399
150Inositol phosphate metabolism_Homo sapiens_hsa005620.46911442
151Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45649495
152Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45367591
153Metabolic pathways_Homo sapiens_hsa011000.43895978
154beta-Alanine metabolism_Homo sapiens_hsa004100.41335297
155Glutathione metabolism_Homo sapiens_hsa004800.39259879
156Fatty acid metabolism_Homo sapiens_hsa012120.38170221
157Folate biosynthesis_Homo sapiens_hsa007900.37206916
158Thyroid cancer_Homo sapiens_hsa052160.35882710
159Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30857026
160Retinol metabolism_Homo sapiens_hsa008300.30751991
161Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30592482
162Tryptophan metabolism_Homo sapiens_hsa003800.25498340
163Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24599139
164Fatty acid degradation_Homo sapiens_hsa000710.24591360
165Caffeine metabolism_Homo sapiens_hsa002320.23465654
166Fat digestion and absorption_Homo sapiens_hsa049750.21029896
167Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20719437

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