ZIC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)6.60810955
2regulation of gene silencing by miRNA (GO:0060964)6.60810955
3regulation of gene silencing by RNA (GO:0060966)6.60810955
4nuclear pore organization (GO:0006999)5.01422231
5nuclear pore complex assembly (GO:0051292)4.73628442
6pre-miRNA processing (GO:0031054)4.58024588
7DNA replication-dependent nucleosome assembly (GO:0006335)4.52639071
8DNA replication-dependent nucleosome organization (GO:0034723)4.52639071
9DNA unwinding involved in DNA replication (GO:0006268)4.33383916
10regulation of helicase activity (GO:0051095)4.27344412
11protein localization to kinetochore (GO:0034501)4.27211556
12paraxial mesoderm development (GO:0048339)4.24738499
13DNA replication initiation (GO:0006270)4.16523581
14regulation of cell fate specification (GO:0042659)4.08338568
15anterior/posterior axis specification, embryo (GO:0008595)4.07244923
16somatic diversification of immune receptors via somatic mutation (GO:0002566)4.06911579
17somatic hypermutation of immunoglobulin genes (GO:0016446)4.06911579
18folic acid-containing compound biosynthetic process (GO:0009396)4.05399757
19histone H4-K12 acetylation (GO:0043983)4.00485233
20mitotic sister chromatid segregation (GO:0000070)3.93196931
21regulation of gene silencing (GO:0060968)3.82391981
22CENP-A containing nucleosome assembly (GO:0034080)3.82233198
23mitotic metaphase plate congression (GO:0007080)3.81714541
24mitotic nuclear envelope disassembly (GO:0007077)3.80604849
25heterochromatin organization (GO:0070828)3.79347787
26regulation of mesoderm development (GO:2000380)3.74159062
27positive regulation of SMAD protein import into nucleus (GO:0060391)3.71367428
28regulation of telomere maintenance via telomerase (GO:0032210)3.69484247
29IMP biosynthetic process (GO:0006188)3.62712281
30dorsal/ventral axis specification (GO:0009950)3.59985342
31regulation of histone H3-K9 methylation (GO:0051570)3.59847716
32nodal signaling pathway (GO:0038092)3.59081050
33negative regulation of histone methylation (GO:0031061)3.55036057
34DNA duplex unwinding (GO:0032508)3.54780117
35nuclear envelope disassembly (GO:0051081)3.53545773
36membrane disassembly (GO:0030397)3.53545773
37DNA geometric change (GO:0032392)3.53504209
38histone arginine methylation (GO:0034969)3.53430531
39determination of adult lifespan (GO:0008340)3.53355371
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.51775836
41formation of translation preinitiation complex (GO:0001731)3.51219864
42pore complex assembly (GO:0046931)3.49953009
43establishment of apical/basal cell polarity (GO:0035089)3.49091553
44sister chromatid segregation (GO:0000819)3.48471736
45ribosome biogenesis (GO:0042254)3.48402046
46L-serine metabolic process (GO:0006563)3.47886254
47DNA strand elongation involved in DNA replication (GO:0006271)3.43008511
48histone exchange (GO:0043486)3.41719932
49metaphase plate congression (GO:0051310)3.40067701
50DNA replication-independent nucleosome organization (GO:0034724)3.39425561
51DNA replication-independent nucleosome assembly (GO:0006336)3.39425561
52protein localization to chromosome, centromeric region (GO:0071459)3.38614051
53nucleobase biosynthetic process (GO:0046112)3.37935754
54embryonic process involved in female pregnancy (GO:0060136)3.37399913
55negative regulation of gene silencing (GO:0060969)3.36047729
56ribosome assembly (GO:0042255)3.35043187
57negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.31173615
58negative regulation of translation, ncRNA-mediated (GO:0040033)3.31173615
59regulation of translation, ncRNA-mediated (GO:0045974)3.31173615
60regulation of sister chromatid cohesion (GO:0007063)3.30807609
61maturation of SSU-rRNA (GO:0030490)3.28648927
62peptidyl-arginine omega-N-methylation (GO:0035247)3.26689995
63negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.25603680
64DNA strand elongation (GO:0022616)3.24267981
65cell migration involved in gastrulation (GO:0042074)3.23123509
66presynaptic membrane assembly (GO:0097105)3.22883051
67DNA replication checkpoint (GO:0000076)3.20660290
68positive regulation of chromosome segregation (GO:0051984)3.18671898
69regulation of SMAD protein import into nucleus (GO:0060390)3.18176212
70negative regulation of androgen receptor signaling pathway (GO:0060766)3.17169630
71G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.15176011
72cell fate commitment involved in formation of primary germ layer (GO:0060795)3.14645796
73regulation of centrosome cycle (GO:0046605)3.14547227
74regulation of cell fate commitment (GO:0010453)3.14078343
75regulation of translational fidelity (GO:0006450)3.13617208
76IMP metabolic process (GO:0046040)3.11902139
77protein complex localization (GO:0031503)3.10781355
78ribonucleoprotein complex biogenesis (GO:0022613)3.09840507
79chromatin assembly (GO:0031497)3.09679111
80DNA damage response, detection of DNA damage (GO:0042769)3.09413687
81ATP-dependent chromatin remodeling (GO:0043044)3.08889807
82establishment of integrated proviral latency (GO:0075713)3.08323724
83regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.07903197
84regulation of mitotic spindle checkpoint (GO:1903504)3.07903197
85regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.07210758
86regulation of hippo signaling (GO:0035330)3.04979184
87notochord development (GO:0030903)3.04506188
88lateral sprouting from an epithelium (GO:0060601)3.04369655
89DNA double-strand break processing (GO:0000729)3.03744340
90regulation of centriole replication (GO:0046599)3.03176711
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01808532
92telomere maintenance via semi-conservative replication (GO:0032201)3.01100368
93negative regulation of cell fate specification (GO:0009996)3.01084312
94positive regulation of mitotic sister chromatid separation (GO:1901970)2.98902780
95positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98902780
96positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98902780
97kinetochore organization (GO:0051383)2.98799451
98establishment or maintenance of monopolar cell polarity (GO:0061339)2.97341751
99establishment of monopolar cell polarity (GO:0061162)2.97341751
100lung-associated mesenchyme development (GO:0060484)2.96833475
101mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.96560979
102negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96553348
103negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96553348
104negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96553348
105negative regulation of mitotic sister chromatid separation (GO:2000816)2.96553348
106negative regulation of sister chromatid segregation (GO:0033046)2.96553348
107histone H4-K5 acetylation (GO:0043981)2.95359425
108histone H4-K8 acetylation (GO:0043982)2.95359425
109chromatin remodeling at centromere (GO:0031055)2.91929122
110regulation of mitotic spindle organization (GO:0060236)2.91594091
111primitive streak formation (GO:0090009)2.89897684
112purine nucleobase biosynthetic process (GO:0009113)2.89818752
113cell surface receptor signaling pathway involved in heart development (GO:0061311)2.88224835
114histone H2A monoubiquitination (GO:0035518)2.87830498
115negative regulation of chromosome segregation (GO:0051985)2.87765678
116presynaptic membrane organization (GO:0097090)2.86696289
117establishment of chromosome localization (GO:0051303)2.86575451
118regulation of spindle organization (GO:0090224)2.85157660
119kinetochore assembly (GO:0051382)2.84901867
120mitotic chromosome condensation (GO:0007076)2.84867739
121peptidyl-arginine N-methylation (GO:0035246)2.83157210
122peptidyl-arginine methylation (GO:0018216)2.83157210
123ribosomal small subunit biogenesis (GO:0042274)2.82299066
124female gonad development (GO:0008585)2.82186420
125regulation of chromosome segregation (GO:0051983)2.81333575
126spindle checkpoint (GO:0031577)2.80751543
127spliceosomal tri-snRNP complex assembly (GO:0000244)2.80671594
128mitotic spindle checkpoint (GO:0071174)2.80272114
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.79644493
130establishment of viral latency (GO:0019043)2.79595442
131polarized epithelial cell differentiation (GO:0030859)2.79493707
132protein K6-linked ubiquitination (GO:0085020)2.78287563
133negative regulation of cell fate commitment (GO:0010454)2.78155858
134maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.76740233
135somite rostral/caudal axis specification (GO:0032525)2.76527881
136trophectodermal cell differentiation (GO:0001829)2.76244633
137intra-S DNA damage checkpoint (GO:0031573)2.75166777
138regulation of centrosome duplication (GO:0010824)2.74660547
139regulation of gastrulation (GO:0010470)2.74272287
140DNA ligation (GO:0006266)2.73109494
141anterior/posterior axis specification (GO:0009948)2.72221260
142mesenchymal to epithelial transition (GO:0060231)2.72045137
143negative regulation of DNA recombination (GO:0045910)2.70760305
144outer ear morphogenesis (GO:0042473)2.69333866
145mitotic spindle assembly checkpoint (GO:0007094)2.63932265
146regulation of development, heterochronic (GO:0040034)2.63623321
147double-strand break repair via nonhomologous end joining (GO:0006303)2.61686391
148non-recombinational repair (GO:0000726)2.61686391
149regulation of mitotic metaphase/anaphase transition (GO:0030071)2.60023335
150regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.60023335
151kidney morphogenesis (GO:0060993)2.59713569
152spindle assembly checkpoint (GO:0071173)2.58485767
153convergent extension (GO:0060026)2.58414079
154olfactory bulb development (GO:0021772)2.55445548
155regulation of chromatin silencing (GO:0031935)2.53633619
156negative regulation of mitosis (GO:0045839)2.51311375
157ncRNA catabolic process (GO:0034661)2.49757929
158regulation of sister chromatid segregation (GO:0033045)2.49666776
159regulation of mitotic sister chromatid segregation (GO:0033047)2.49666776

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.89513389
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.36545164
3* KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.18125432
4* KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.18125432
5* KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.18125432
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.93608675
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.91938274
8* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.50790678
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.39106977
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.30298700
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.26152269
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.05291287
13* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.92777808
14TCF3_18692474_ChIP-Seq_MEFs_Mouse2.76882618
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73333430
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63322041
17TCF3_18692474_ChIP-Seq_MESCs_Mouse2.55164610
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.54798178
19NANOG_18555785_ChIP-Seq_MESCs_Mouse2.52863346
20SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.50825919
21ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.48960404
22SOX2_18555785_ChIP-Seq_MESCs_Mouse2.45914796
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.44026266
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.43484622
25POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.40339835
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.33614183
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.29431717
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.27997447
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.27946696
30MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23099045
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21310852
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12717343
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10462802
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.10335355
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.06969288
36EZH2_22144423_ChIP-Seq_EOC_Human2.04085078
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.95773784
38NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.95418429
39XRN2_22483619_ChIP-Seq_HELA_Human1.81290379
40NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.80840269
41EWS_26573619_Chip-Seq_HEK293_Human1.80115587
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.76883890
43* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.75603759
44FUS_26573619_Chip-Seq_HEK293_Human1.75057611
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71799595
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.70478408
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70345682
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69132940
49TAF15_26573619_Chip-Seq_HEK293_Human1.66069978
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61497710
51* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.61263893
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.60631438
53SOX2_18692474_ChIP-Seq_MEFs_Mouse1.59440867
54IGF1R_20145208_ChIP-Seq_DFB_Human1.58935008
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58005525
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.56877100
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.56708460
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.56087551
59* P300_19829295_ChIP-Seq_ESCs_Human1.55953726
60SOX2_18692474_ChIP-Seq_MESCs_Mouse1.55013309
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.51922017
62AR_21909140_ChIP-Seq_LNCAP_Human1.50237282
63* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.49600218
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49531402
65NANOG_21062744_ChIP-ChIP_HESCs_Human1.49276650
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49217305
67* TP63_19390658_ChIP-ChIP_HaCaT_Human1.49195300
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48532173
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45092354
70* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.44385879
71TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.43731547
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43080715
73OCT4_18692474_ChIP-Seq_MEFs_Mouse1.42548071
74MYC_18940864_ChIP-ChIP_HL60_Human1.41604448
75ZNF274_21170338_ChIP-Seq_K562_Hela1.40901262
76TTF2_22483619_ChIP-Seq_HELA_Human1.37949802
77GATA1_26923725_Chip-Seq_HPCs_Mouse1.37247466
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33401226
79POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.32539351
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.32332231
81* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.29614692
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29437261
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28434623
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28397765
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.26625292
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25108939
87* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.24752452
88VDR_22108803_ChIP-Seq_LS180_Human1.23575109
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21096719
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20169322
91YY1_21170310_ChIP-Seq_MESCs_Mouse1.18910646
92* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.17660464
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17067913
94* RNF2_27304074_Chip-Seq_NSC_Mouse1.16707078
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16666341
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15411424
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15411424
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15056962
99GABP_17652178_ChIP-ChIP_JURKAT_Human1.14675072
100ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12930796
101* SMAD3_21741376_ChIP-Seq_EPCs_Human1.12644051
102TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11532695
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09386630
104* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09185507
105* SOX2_16153702_ChIP-ChIP_HESCs_Human1.07808928
106VDR_23849224_ChIP-Seq_CD4+_Human1.07677530
107KAP1_27257070_Chip-Seq_ESCs_Mouse1.07275379
108* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06314655
109CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06016230
110ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05722433
111* NANOG_16153702_ChIP-ChIP_HESCs_Human1.05559873
112MYC_22102868_ChIP-Seq_BL_Human1.05367234
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05130575
114* NANOG_16518401_ChIP-PET_MESCs_Mouse1.04489626
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04443116
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04123551
117DCP1A_22483619_ChIP-Seq_HELA_Human1.03353011
118FLI1_27457419_Chip-Seq_LIVER_Mouse1.02230710
119* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01015126
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00514588
121FOXP3_21729870_ChIP-Seq_TREG_Human1.00294055
122SOX9_26525672_Chip-Seq_HEART_Mouse0.99228248
123KDM5A_27292631_Chip-Seq_BREAST_Human0.99211504
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98906332
125HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98362976
126GBX2_23144817_ChIP-Seq_PC3_Human0.98094244
127* IRF1_19129219_ChIP-ChIP_H3396_Human0.97896532
128* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97417763
129FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97201856
130GABP_19822575_ChIP-Seq_HepG2_Human0.95666021
131ELK1_19687146_ChIP-ChIP_HELA_Human0.93561243
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85603679
133* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85470297
134NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.82942658
135DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82787047
136* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.78472977
137PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78318378
138* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.77506159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.95393578
2MP0004957_abnormal_blastocyst_morpholog3.91176674
3MP0010094_abnormal_chromosome_stability3.46864834
4MP0003111_abnormal_nucleus_morphology3.43651394
5MP0003693_abnormal_embryo_hatching3.36343039
6MP0002653_abnormal_ependyma_morphology3.16253810
7MP0003890_abnormal_embryonic-extraembry3.06229374
8MP0003077_abnormal_cell_cycle3.04104352
9* MP0004133_heterotaxia2.83181260
10MP0010030_abnormal_orbit_morphology2.66298193
11MP0003122_maternal_imprinting2.57061745
12MP0010352_gastrointestinal_tract_polyps2.40372293
13MP0003123_paternal_imprinting2.38955837
14MP0008058_abnormal_DNA_repair2.38587427
15MP0008932_abnormal_embryonic_tissue2.32565883
16MP0003119_abnormal_digestive_system2.32088720
17* MP0002084_abnormal_developmental_patter2.21678685
18* MP0001730_embryonic_growth_arrest2.20619895
19MP0006292_abnormal_olfactory_placode2.19953835
20MP0000350_abnormal_cell_proliferation2.19770130
21* MP0002085_abnormal_embryonic_tissue2.16054757
22MP0003136_yellow_coat_color2.15708785
23* MP0005380_embryogenesis_phenotype2.11716122
24* MP0001672_abnormal_embryogenesis/_devel2.11716122
25MP0003283_abnormal_digestive_organ2.03867824
26MP0001293_anophthalmia1.96582044
27MP0001697_abnormal_embryo_size1.93689489
28MP0003941_abnormal_skin_development1.88760055
29MP0003121_genomic_imprinting1.86055292
30MP0004197_abnormal_fetal_growth/weight/1.85087681
31* MP0002086_abnormal_extraembryonic_tissu1.83905665
32MP0005623_abnormal_meninges_morphology1.80537949
33MP0003806_abnormal_nucleotide_metabolis1.78134434
34* MP0003984_embryonic_growth_retardation1.77692136
35MP0008007_abnormal_cellular_replicative1.76081971
36* MP0002088_abnormal_embryonic_growth/wei1.75741115
37MP0000778_abnormal_nervous_system1.71909052
38MP0001529_abnormal_vocalization1.63363137
39MP0003880_abnormal_central_pattern1.61161074
40MP0000566_synostosis1.58318034
41MP0005076_abnormal_cell_differentiation1.56813209
42MP0003786_premature_aging1.54924588
43* MP0002080_prenatal_lethality1.53547040
44MP0003718_maternal_effect1.40463696
45MP0000516_abnormal_urinary_system1.39220615
46MP0005367_renal/urinary_system_phenotyp1.39220615
47MP0008877_abnormal_DNA_methylation1.39040724
48MP0010307_abnormal_tumor_latency1.38863041
49MP0003937_abnormal_limbs/digits/tail_de1.35643155
50MP0001849_ear_inflammation1.34155699
51MP0005248_abnormal_Harderian_gland1.33541835
52MP0001286_abnormal_eye_development1.32740686
53MP0001299_abnormal_eye_distance/1.31926461
54MP0000579_abnormal_nail_morphology1.28776772
55* MP0003861_abnormal_nervous_system1.27489449
56MP0000631_abnormal_neuroendocrine_gland1.25950095
57MP0003567_abnormal_fetal_cardiomyocyte1.24947371
58MP0001984_abnormal_olfaction1.24648388
59MP0002736_abnormal_nociception_after1.24354923
60MP0003385_abnormal_body_wall1.22494001
61MP0000537_abnormal_urethra_morphology1.20077115
62MP0005377_hearing/vestibular/ear_phenot1.19748190
63MP0003878_abnormal_ear_physiology1.19748190
64MP0005167_abnormal_blood-brain_barrier1.18412132
65MP0000049_abnormal_middle_ear1.17474198
66MP0002697_abnormal_eye_size1.16737999
67MP0009053_abnormal_anal_canal1.15616042
68MP0003705_abnormal_hypodermis_morpholog1.14507960
69* MP0002111_abnormal_tail_morphology1.13215759
70MP0002102_abnormal_ear_morphology1.12910321
71MP0001485_abnormal_pinna_reflex1.10970086
72MP0003935_abnormal_craniofacial_develop1.10581428
73* MP0000432_abnormal_head_morphology1.09063217
74MP0005171_absent_coat_pigmentation1.08950182
75MP0003755_abnormal_palate_morphology1.08832307
76MP0002751_abnormal_autonomic_nervous1.08538574
77MP0002092_abnormal_eye_morphology1.07454017
78MP0010234_abnormal_vibrissa_follicle1.03795244
79MP0000313_abnormal_cell_death1.03760964
80MP0003942_abnormal_urinary_system1.03699270
81MP0005187_abnormal_penis_morphology1.02744770
82MP0005394_taste/olfaction_phenotype1.00202505
83MP0005499_abnormal_olfactory_system1.00202505
84MP0003315_abnormal_perineum_morphology1.00135801
85MP0002210_abnormal_sex_determination0.99426245
86MP0001145_abnormal_male_reproductive0.98842080
87MP0002332_abnormal_exercise_endurance0.97040671
88MP0004264_abnormal_extraembryonic_tissu0.95837481
89* MP0002925_abnormal_cardiovascular_devel0.95796584
90MP0006054_spinal_hemorrhage0.95039528
91* MP0002152_abnormal_brain_morphology0.94001046
92MP0009703_decreased_birth_body0.92965917
93MP0005266_abnormal_metabolism0.92341644
94MP0001177_atelectasis0.91764949
95MP0001915_intracranial_hemorrhage0.91578318
96MP0008789_abnormal_olfactory_epithelium0.89948706
97MP0002160_abnormal_reproductive_system0.89667300
98MP0001188_hyperpigmentation0.89484864
99MP0000428_abnormal_craniofacial_morphol0.87703346
100MP0006276_abnormal_autonomic_nervous0.87540041
101MP0006072_abnormal_retinal_apoptosis0.87144601
102MP0000955_abnormal_spinal_cord0.86107579
103MP0000647_abnormal_sebaceous_gland0.85916051
104MP0002233_abnormal_nose_morphology0.85663644
105* MP0002249_abnormal_larynx_morphology0.84148229
106MP0005253_abnormal_eye_physiology0.84057071
107MP0000762_abnormal_tongue_morphology0.83974091
108MP0003938_abnormal_ear_development0.83958740
109MP0002234_abnormal_pharynx_morphology0.83455497
110* MP0002752_abnormal_somatic_nervous0.82168892
111MP0003936_abnormal_reproductive_system0.81322724
112MP0000490_abnormal_crypts_of0.81209618
113MP0003566_abnormal_cell_adhesion0.81055905
114MP0003137_abnormal_impulse_conducting0.77715026
115MP0002184_abnormal_innervation0.76722472
116MP0002282_abnormal_trachea_morphology0.75821296
117MP0002090_abnormal_vision0.75334264
118MP0002254_reproductive_system_inflammat0.75001692
119MP0009278_abnormal_bone_marrow0.74251048
120MP0002019_abnormal_tumor_incidence0.74163293
121MP0003787_abnormal_imprinting0.73928231
122MP0005391_vision/eye_phenotype0.73266617
123MP0002932_abnormal_joint_morphology0.73150164
124MP0009250_abnormal_appendicular_skeleto0.72478832
125MP0000653_abnormal_sex_gland0.72199597
126* MP0002116_abnormal_craniofacial_bone0.72099087
127MP0000534_abnormal_ureter_morphology0.71590671
128MP0009672_abnormal_birth_weight0.71094053
129MP0001929_abnormal_gametogenesis0.70591420
130MP0005501_abnormal_skin_physiology0.69656384
131* MP0002114_abnormal_axial_skeleton0.68349286
132MP0005389_reproductive_system_phenotype0.67011613
133MP0002081_perinatal_lethality0.65925519
134MP0008770_decreased_survivor_rate0.65412287
135MP0002938_white_spotting0.63693644
136MP0001348_abnormal_lacrimal_gland0.61138449

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.22089887
2Rib fusion (HP:0000902)4.38204215
3Abnormality of the labia minora (HP:0012880)4.03423767
4Medulloblastoma (HP:0002885)3.86635688
5Astrocytoma (HP:0009592)3.82792753
6Abnormality of the astrocytes (HP:0100707)3.82792753
7Neoplasm of the oral cavity (HP:0100649)3.55220451
8Rectal fistula (HP:0100590)3.32161041
9Rectovaginal fistula (HP:0000143)3.32161041
10Hepatoblastoma (HP:0002884)3.30168920
11* Absent radius (HP:0003974)3.27626892
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.27364948
13Rhabdomyosarcoma (HP:0002859)3.24040065
14Selective tooth agenesis (HP:0001592)3.23600852
15Myelomeningocele (HP:0002475)3.23222295
16Cortical dysplasia (HP:0002539)3.16368596
17Chromsome breakage (HP:0040012)3.13961244
18* Supernumerary spleens (HP:0009799)3.12622272
19Missing ribs (HP:0000921)3.11992724
20Esophageal atresia (HP:0002032)3.08980336
21* Aplasia involving forearm bones (HP:0009822)3.08808701
22* Absent forearm bone (HP:0003953)3.08808701
23Glioma (HP:0009733)3.07923598
24Breast hypoplasia (HP:0003187)3.07815643
25Colon cancer (HP:0003003)3.01997448
26Birth length less than 3rd percentile (HP:0003561)3.01476305
27Neoplasm of striated muscle (HP:0009728)2.99170430
28Intestinal fistula (HP:0100819)2.90407472
29Agnosia (HP:0010524)2.87342093
30Shawl scrotum (HP:0000049)2.85699080
31Absent septum pellucidum (HP:0001331)2.83146580
32Bifid tongue (HP:0010297)2.80214553
33Absent thumb (HP:0009777)2.79137877
34Abnormal number of incisors (HP:0011064)2.73835342
35Vaginal fistula (HP:0004320)2.73688468
36Abnormality of the septum pellucidum (HP:0007375)2.73310858
37* Aplasia/hypoplasia of the humerus (HP:0006507)2.71324910
38Stenosis of the external auditory canal (HP:0000402)2.68680601
39Patellar aplasia (HP:0006443)2.68139618
40Impulsivity (HP:0100710)2.66826191
41Reticulocytopenia (HP:0001896)2.59907460
42Meckel diverticulum (HP:0002245)2.58272876
43Abnormality of the ileum (HP:0001549)2.57109813
44Supernumerary ribs (HP:0005815)2.55729974
45Cutaneous finger syndactyly (HP:0010554)2.53579289
46Supernumerary bones of the axial skeleton (HP:0009144)2.53029220
47Cutaneous syndactyly (HP:0012725)2.51066551
48Gastrointestinal atresia (HP:0002589)2.50676755
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.49926044
50Carpal bone hypoplasia (HP:0001498)2.49644502
51* Short humerus (HP:0005792)2.46328294
52Vertebral fusion (HP:0002948)2.45083444
53Fused cervical vertebrae (HP:0002949)2.43784995
54Abnormality of the salivary glands (HP:0010286)2.43033098
55Aplasia/Hypoplasia of the patella (HP:0006498)2.42076493
56Optic nerve hypoplasia (HP:0000609)2.40902717
57Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.40554185
58Hypoplastic pelvis (HP:0008839)2.38212188
59Maternal diabetes (HP:0009800)2.37326394
60Hemivertebrae (HP:0002937)2.35820438
61Anal stenosis (HP:0002025)2.35693667
62Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.35211620
63High anterior hairline (HP:0009890)2.33445242
64Abnormal sex determination (HP:0012244)2.33394516
65Sex reversal (HP:0012245)2.33394516
66Hyperglycinemia (HP:0002154)2.30454596
67* Abdominal situs inversus (HP:0003363)2.30414958
68* Abnormality of abdominal situs (HP:0011620)2.30414958
69Preaxial foot polydactyly (HP:0001841)2.28401186
70Renal hypoplasia (HP:0000089)2.26692931
71Intestinal atresia (HP:0011100)2.26356585
72Abnormality of chromosome stability (HP:0003220)2.21983681
73Malignant gastrointestinal tract tumors (HP:0006749)2.20596301
74Gastrointestinal carcinoma (HP:0002672)2.20596301
75Septo-optic dysplasia (HP:0100842)2.17830490
76Labial hypoplasia (HP:0000066)2.17681334
77Spastic diplegia (HP:0001264)2.16983925
78Abnormality of the lower motor neuron (HP:0002366)2.16403963
79Nephroblastoma (Wilms tumor) (HP:0002667)2.15991608
80Aqueductal stenosis (HP:0002410)2.15724883
81Hypoplastic female external genitalia (HP:0012815)2.15653116
82Basal cell carcinoma (HP:0002671)2.15246087
83Pseudobulbar signs (HP:0002200)2.14348244
84Aplasia/Hypoplasia of the sternum (HP:0006714)2.12930010
85Abnormality of the preputium (HP:0100587)2.11432605
86Choanal stenosis (HP:0000452)2.10158698
87Facial hemangioma (HP:0000329)2.08411523
88Biliary tract neoplasm (HP:0100574)2.08382322
89Trigonocephaly (HP:0000243)2.08140643
90Horseshoe kidney (HP:0000085)2.07473487
91Abnormal lung lobation (HP:0002101)2.06990214
92Anophthalmia (HP:0000528)2.06429474
93Breast aplasia (HP:0100783)2.04043999
94Skull defect (HP:0001362)2.01422948
95Vaginal atresia (HP:0000148)2.01024969
96Preaxial hand polydactyly (HP:0001177)2.00908860
97Small intestinal stenosis (HP:0012848)1.99229206
98Duodenal stenosis (HP:0100867)1.99229206
99Bilateral microphthalmos (HP:0007633)1.99111873
100Broad thumb (HP:0011304)1.98167037
101Broad foot (HP:0001769)1.97575285
102Embryonal renal neoplasm (HP:0011794)1.96913865
103Abnormality of the duodenum (HP:0002246)1.96428365
104Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.96315592
105Oral leukoplakia (HP:0002745)1.95515870
106Duplicated collecting system (HP:0000081)1.95221471
107Meningocele (HP:0002435)1.94826936
108Atresia of the external auditory canal (HP:0000413)1.94623884
109Volvulus (HP:0002580)1.94511099
110Short 1st metacarpal (HP:0010034)1.94433192
111Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.94433192
112Generalized hypotonia (HP:0001290)1.94038502
113Genital tract atresia (HP:0001827)1.94012110
114Oligodactyly (HP:0012165)1.91292006
115Hyperglycinuria (HP:0003108)1.89804900
116Short hallux (HP:0010109)1.89543199
117Trismus (HP:0000211)1.88978464
118Aplasia/Hypoplasia of the hallux (HP:0008362)1.88677442
119Adactyly (HP:0009776)1.88597394
120Abnormality of the middle phalanges of the toes (HP:0010183)1.87099199
121Oligodactyly (hands) (HP:0001180)1.86760747
122Triphalangeal thumb (HP:0001199)1.86757432
123Short phalanx of the thumb (HP:0009660)1.86123921
124Anencephaly (HP:0002323)1.85813111
125Increased nuchal translucency (HP:0010880)1.85327175
126Ectopic kidney (HP:0000086)1.85226839
127Chronic bronchitis (HP:0004469)1.83748159
128Omphalocele (HP:0001539)1.83385122
129Short thumb (HP:0009778)1.82100118
130Abnormality of glycine metabolism (HP:0010895)1.81443465
131Abnormality of serine family amino acid metabolism (HP:0010894)1.81443465
132Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.81128890
133Aplasia/Hypoplasia of the breasts (HP:0010311)1.80577283
134Micropenis (HP:0000054)1.80406426
135Duplication of thumb phalanx (HP:0009942)1.80299223
136Hypochromic microcytic anemia (HP:0004840)1.79596664
137Preauricular skin tag (HP:0000384)1.78944966
138Neoplasm of the pancreas (HP:0002894)1.78717335
13911 pairs of ribs (HP:0000878)1.78444248
140* Tracheoesophageal fistula (HP:0002575)1.77926856
141Vertebral clefting (HP:0008428)1.77354252
142Exercise-induced muscle cramps (HP:0003710)1.76680186
143Absent hand (HP:0004050)1.76505533
144Dandy-Walker malformation (HP:0001305)1.76409916
145Sloping forehead (HP:0000340)1.75931675
146Facial cleft (HP:0002006)1.73582221
147Abnormal hair whorl (HP:0010721)1.73047461
148Coronal craniosynostosis (HP:0004440)1.71143909
149Partial duplication of thumb phalanx (HP:0009944)1.69353303
150Gonadotropin excess (HP:0000837)1.68621642
151Midline defect of the nose (HP:0004122)1.68548876
152Holoprosencephaly (HP:0001360)1.68241431
153Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.68133077
154Primary amenorrhea (HP:0000786)1.67947147
155True hermaphroditism (HP:0010459)1.65218979
156Pancreatic fibrosis (HP:0100732)1.65198666
157Absent eyebrow (HP:0002223)1.64696549
158Erectile abnormalities (HP:0100639)1.64236416
159Abnormality of the aortic arch (HP:0012303)1.63469199
160Abnormality of the phalanges of the 5th finger (HP:0004213)1.61888139
161Abnormal umbilical cord blood vessels (HP:0011403)1.61420654
162Single umbilical artery (HP:0001195)1.61420654
163Abnormality of the fetal cardiovascular system (HP:0010948)1.61420654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.66231506
2WEE13.67410009
3EPHA23.66648709
4CDC73.65749256
5TNIK3.46869161
6BUB12.94207459
7TTK2.85460503
8NEK12.65969895
9PNCK2.59165564
10WNK32.54387539
11TRIM282.43690636
12RPS6KB22.37775859
13ACVR1B2.27004747
14CDK72.26506269
15CDK192.23898084
16SRPK12.18829692
17AKT32.16321287
18NEK22.12001071
19LATS22.05984066
20PLK11.99024513
21TSSK61.83911521
22EPHA41.83228112
23MAP3K41.80674886
24CASK1.78985203
25BRD41.70009217
26VRK21.68475535
27ICK1.66463216
28CHEK21.65834972
29BMPR1B1.61997144
30NUAK11.58774879
31MKNK11.54469907
32MKNK21.50730323
33CHEK11.43700972
34TAF11.43126162
35PLK31.41918326
36PAK41.39345749
37ATR1.36361325
38PASK1.35410886
39ALK1.35342972
40AURKB1.34794094
41TESK21.34690119
42TLK11.26906926
43MAP2K71.26587030
44AURKA1.26414837
45TYRO31.21494539
46DYRK31.21006947
47STK101.17932386
48PLK21.17528003
49VRK11.16768732
50GRK11.14111598
51CDK41.13842481
52ATM1.11280794
53MAP3K81.11149028
54CDK21.10568449
55CSNK1G11.09957175
56CSNK1G21.09658696
57EPHB21.08188335
58MET1.03121961
59CDK61.01614216
60FGFR21.00911328
61MTOR0.93192742
62STK160.92952770
63KDR0.90225306
64TGFBR10.88724072
65AKT20.86238314
66ERBB30.83810595
67RPS6KA40.83717044
68STK30.83404863
69PIM10.82657058
70CSNK1G30.82293564
71MARK10.81989122
72CSNK1E0.81194587
73PRKCI0.79854463
74PLK40.78914553
75NLK0.77624091
76CDK10.77551587
77CAMK1G0.77084976
78STK38L0.76961647
79EIF2AK10.76672544
80BMX0.76551941
81DYRK1A0.75784376
82DYRK20.75635321
83CSNK2A20.74278650
84MAP3K100.74126648
85CSNK1D0.72068356
86FLT30.71861572
87CSNK1A1L0.69963647
88MELK0.68404848
89NTRK20.68046870
90MAP3K90.67904614
91FGR0.67580605
92MAP4K20.67032542
93SCYL20.66872959
94ERBB40.66209223
95BRSK10.66178756
96BCR0.65141017
97DDR20.65092023
98BCKDK0.64958093
99LATS10.61550298
100BRSK20.59085997
101MAPKAPK30.58643600
102PAK10.58573927
103CDK180.57465632
104OXSR10.57298512
105STK40.57202164
106GRK60.56602343
107YES10.55818755
108PDGFRA0.54841926
109CSNK2A10.54430092
110MATK0.53984297
111PRKCG0.53168783
112NTRK10.52886390
113EEF2K0.52620831
114FGFR10.52230739
115NME10.52182561
116CDK11A0.51881785
117PRKDC0.51001970
118CDK150.50869082
119MAPK140.48191154
120TIE10.47093700
121PAK20.46796632
122PDK20.46283946
123CDK140.44502128
124GSK3B0.44349817
125DYRK1B0.43138487
126MAPK10.42689760
127EIF2AK20.41547196
128MINK10.41099938
129CAMK1D0.40996103
130MAPK100.40917934
131CDK30.40440903
132STK240.39571939
133EIF2AK30.36295576
134ERBB20.36202787
135AKT10.35602115
136DAPK10.35345062
137SIK30.34864036
138ROCK20.32109870
139GSK3A0.29822577
140PBK0.29165427
141MAP2K20.27930235
142MAPK150.27866402
143BRAF0.27312421
144UHMK10.27184935
145PTK20.26653170
146MST40.26642547
147MAPK70.26014893
148ZAK0.21457355
149RIPK10.21271472

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.63488565
2DNA replication_Homo sapiens_hsa030304.33845932
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.16126878
4Spliceosome_Homo sapiens_hsa030403.56158161
5RNA transport_Homo sapiens_hsa030133.42451773
6One carbon pool by folate_Homo sapiens_hsa006703.31334877
7Steroid biosynthesis_Homo sapiens_hsa001002.88694292
8Ribosome_Homo sapiens_hsa030102.84778910
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.78508951
10Nucleotide excision repair_Homo sapiens_hsa034202.73069904
11Homologous recombination_Homo sapiens_hsa034402.69383534
12Fanconi anemia pathway_Homo sapiens_hsa034602.66394444
13RNA polymerase_Homo sapiens_hsa030202.64275918
14Base excision repair_Homo sapiens_hsa034102.59625610
15Cell cycle_Homo sapiens_hsa041102.56582501
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.45305565
17mRNA surveillance pathway_Homo sapiens_hsa030152.39425502
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26100317
19Protein export_Homo sapiens_hsa030601.98574960
20RNA degradation_Homo sapiens_hsa030181.91895019
21Basal cell carcinoma_Homo sapiens_hsa052171.85855485
22Propanoate metabolism_Homo sapiens_hsa006401.84497089
23Basal transcription factors_Homo sapiens_hsa030221.75930121
24Pyrimidine metabolism_Homo sapiens_hsa002401.72420290
25* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.72233440
26p53 signaling pathway_Homo sapiens_hsa041151.67992882
27Hippo signaling pathway_Homo sapiens_hsa043901.62794366
28Non-homologous end-joining_Homo sapiens_hsa034501.61109573
29Proteasome_Homo sapiens_hsa030501.47576693
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46915776
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44677240
32Hedgehog signaling pathway_Homo sapiens_hsa043401.44150159
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40562113
34Adherens junction_Homo sapiens_hsa045201.30558278
35Notch signaling pathway_Homo sapiens_hsa043301.28314481
36TGF-beta signaling pathway_Homo sapiens_hsa043501.23701434
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22957404
38Systemic lupus erythematosus_Homo sapiens_hsa053221.22169342
39Oocyte meiosis_Homo sapiens_hsa041141.21872613
40Pyruvate metabolism_Homo sapiens_hsa006201.21214440
41MicroRNAs in cancer_Homo sapiens_hsa052061.16326867
42Biosynthesis of amino acids_Homo sapiens_hsa012301.14599571
43Parkinsons disease_Homo sapiens_hsa050121.09052276
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07410631
45Thyroid cancer_Homo sapiens_hsa052160.99855267
46Nicotine addiction_Homo sapiens_hsa050330.97973625
47Axon guidance_Homo sapiens_hsa043600.96954628
48Tight junction_Homo sapiens_hsa045300.96287564
49Fatty acid elongation_Homo sapiens_hsa000620.96216494
50Viral carcinogenesis_Homo sapiens_hsa052030.94010248
51Wnt signaling pathway_Homo sapiens_hsa043100.92141977
52Oxidative phosphorylation_Homo sapiens_hsa001900.89694642
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87997870
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86815940
55Purine metabolism_Homo sapiens_hsa002300.82810061
56Colorectal cancer_Homo sapiens_hsa052100.80229427
57Butanoate metabolism_Homo sapiens_hsa006500.79497659
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.79436836
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79092504
60Epstein-Barr virus infection_Homo sapiens_hsa051690.78762520
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78740455
62Fatty acid metabolism_Homo sapiens_hsa012120.74114143
63HTLV-I infection_Homo sapiens_hsa051660.72098735
64Pathways in cancer_Homo sapiens_hsa052000.70263166
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.68989046
66mTOR signaling pathway_Homo sapiens_hsa041500.68346270
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.67663947
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67190856
69Selenocompound metabolism_Homo sapiens_hsa004500.66671082
70Melanoma_Homo sapiens_hsa052180.64892920
71Alcoholism_Homo sapiens_hsa050340.63744000
72Bladder cancer_Homo sapiens_hsa052190.63254168
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63231415
74Fructose and mannose metabolism_Homo sapiens_hsa000510.60719405
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60520626
76Cardiac muscle contraction_Homo sapiens_hsa042600.53324877
77Small cell lung cancer_Homo sapiens_hsa052220.52129426
78Metabolic pathways_Homo sapiens_hsa011000.50439371
79Phototransduction_Homo sapiens_hsa047440.49396836
80Prostate cancer_Homo sapiens_hsa052150.49391852
81Herpes simplex infection_Homo sapiens_hsa051680.47574232
82Lysine degradation_Homo sapiens_hsa003100.47392106
83HIF-1 signaling pathway_Homo sapiens_hsa040660.45972022
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45101023
85Alzheimers disease_Homo sapiens_hsa050100.44784029
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43963240
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41027135
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40426888
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40066954
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39331943
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39172894
92beta-Alanine metabolism_Homo sapiens_hsa004100.39104957
93Arginine and proline metabolism_Homo sapiens_hsa003300.38412898
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38409280
95Rap1 signaling pathway_Homo sapiens_hsa040150.36033416
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35471301
97Proteoglycans in cancer_Homo sapiens_hsa052050.35367600
98Nitrogen metabolism_Homo sapiens_hsa009100.35258147
99Vitamin digestion and absorption_Homo sapiens_hsa049770.33530798
100Retinol metabolism_Homo sapiens_hsa008300.33261279
101Peroxisome_Homo sapiens_hsa041460.32409602
102Taste transduction_Homo sapiens_hsa047420.31344440
103Endometrial cancer_Homo sapiens_hsa052130.30210484
104Melanogenesis_Homo sapiens_hsa049160.29225221
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28486782
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28415746
107Protein digestion and absorption_Homo sapiens_hsa049740.28311270
108Fatty acid degradation_Homo sapiens_hsa000710.28181647
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27360655
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.26683964
111Carbon metabolism_Homo sapiens_hsa012000.25496972
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25286483
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24637201
114GABAergic synapse_Homo sapiens_hsa047270.23990778
115Vitamin B6 metabolism_Homo sapiens_hsa007500.23348814
116Galactose metabolism_Homo sapiens_hsa000520.23158919
117Folate biosynthesis_Homo sapiens_hsa007900.23150392
118N-Glycan biosynthesis_Homo sapiens_hsa005100.22625109
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.20569425
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20485931
121Renal cell carcinoma_Homo sapiens_hsa052110.19746116
122Serotonergic synapse_Homo sapiens_hsa047260.19649039
123Glutathione metabolism_Homo sapiens_hsa004800.19458842
124Huntingtons disease_Homo sapiens_hsa050160.18474153
125Dorso-ventral axis formation_Homo sapiens_hsa043200.17755915
126Antigen processing and presentation_Homo sapiens_hsa046120.17012653
127Focal adhesion_Homo sapiens_hsa045100.15997737
128Linoleic acid metabolism_Homo sapiens_hsa005910.15095076
129Gap junction_Homo sapiens_hsa045400.14491727
130Pentose phosphate pathway_Homo sapiens_hsa000300.14267167
131Ras signaling pathway_Homo sapiens_hsa040140.14068375
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13431651
133Apoptosis_Homo sapiens_hsa042100.12976008
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.07777430
135Choline metabolism in cancer_Homo sapiens_hsa052310.06341324
136AMPK signaling pathway_Homo sapiens_hsa041520.05731519
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.05510138
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.04738657
139MAPK signaling pathway_Homo sapiens_hsa040100.04259356
140Arachidonic acid metabolism_Homo sapiens_hsa005900.03726704

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