ZIC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)5.74619442
2cerebellar granule cell differentiation (GO:0021707)5.40424102
3locomotory exploration behavior (GO:0035641)4.84069651
4response to pheromone (GO:0019236)4.77928858
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.68663834
6pyrimidine nucleobase catabolic process (GO:0006208)4.68626924
7central nervous system projection neuron axonogenesis (GO:0021952)4.64130570
8cell differentiation in hindbrain (GO:0021533)4.47802554
9layer formation in cerebral cortex (GO:0021819)4.44690478
10cerebellar Purkinje cell differentiation (GO:0021702)4.35624277
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.35509470
12gamma-aminobutyric acid transport (GO:0015812)4.31041901
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.28588894
14neuronal action potential propagation (GO:0019227)4.11272600
15dendrite morphogenesis (GO:0048813)4.06118252
16axonal fasciculation (GO:0007413)4.04659648
17behavioral response to nicotine (GO:0035095)4.03571672
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.99483649
19vocalization behavior (GO:0071625)3.98820637
20glutamate receptor signaling pathway (GO:0007215)3.98766254
21response to gravity (GO:0009629)3.98378546
22regulation of short-term neuronal synaptic plasticity (GO:0048172)3.97184348
23spinal cord development (GO:0021510)3.96133991
24G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.95109775
25regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.93571336
26regulation of glutamate receptor signaling pathway (GO:1900449)3.92786976
27cell proliferation in forebrain (GO:0021846)3.90854361
28synaptic vesicle maturation (GO:0016188)3.88762691
29calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.83887413
30protein localization to synapse (GO:0035418)3.78622058
31nucleobase catabolic process (GO:0046113)3.76405408
32neuron cell-cell adhesion (GO:0007158)3.73492283
33neuron projection extension involved in neuron projection guidance (GO:1902284)3.72141907
34axon extension involved in axon guidance (GO:0048846)3.72141907
35epithelial cilium movement (GO:0003351)3.71715621
36olfactory bulb development (GO:0021772)3.70413446
37regulation of non-canonical Wnt signaling pathway (GO:2000050)3.67856712
38presynaptic membrane organization (GO:0097090)3.66159304
39neuron fate determination (GO:0048664)3.62711253
40positive regulation of dendritic spine morphogenesis (GO:0061003)3.61750071
41nonmotile primary cilium assembly (GO:0035058)3.60010933
42dendritic spine morphogenesis (GO:0060997)3.58561946
43central nervous system neuron axonogenesis (GO:0021955)3.56848345
44cell migration in hindbrain (GO:0021535)3.55147209
45positive regulation of synapse assembly (GO:0051965)3.54496046
46intraciliary transport (GO:0042073)3.50834029
47synaptic transmission, glutamatergic (GO:0035249)3.50033171
48neuronal ion channel clustering (GO:0045161)3.49867006
49postsynaptic membrane organization (GO:0001941)3.49404149
50mechanosensory behavior (GO:0007638)3.47685420
51spinal cord association neuron differentiation (GO:0021527)3.45465410
52neuron recognition (GO:0008038)3.44596820
53cilium movement (GO:0003341)3.41379438
54positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.37052829
55adult walking behavior (GO:0007628)3.36951385
56cerebellum development (GO:0021549)3.36943576
57positive regulation of synapse maturation (GO:0090129)3.34957887
58neurotransmitter-gated ion channel clustering (GO:0072578)3.34627689
59synapse assembly (GO:0007416)3.32309059
60establishment of mitochondrion localization (GO:0051654)3.31328168
61cell communication by electrical coupling (GO:0010644)3.29262700
62mesenchymal-epithelial cell signaling (GO:0060638)3.28600557
63regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.28329382
64axon extension (GO:0048675)3.26934729
65exploration behavior (GO:0035640)3.24540352
66synaptic vesicle docking involved in exocytosis (GO:0016081)3.20834595
67glutamate secretion (GO:0014047)3.18570255
68tongue development (GO:0043586)3.18451116
69atrial cardiac muscle cell action potential (GO:0086014)3.18249769
70neuronal stem cell maintenance (GO:0097150)3.17509422
71regulation of neuron migration (GO:2001222)3.13684523
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.12366562
73auditory behavior (GO:0031223)3.11937392
74negative regulation of axon guidance (GO:1902668)3.10424888
75regulation of synaptic vesicle transport (GO:1902803)3.10032118
76regulation of synaptic vesicle exocytosis (GO:2000300)3.08782525
77presynaptic membrane assembly (GO:0097105)3.08209017
78neurotransmitter secretion (GO:0007269)3.06710853
79positive regulation of dendritic spine development (GO:0060999)3.05394665
80ephrin receptor signaling pathway (GO:0048013)3.03877197
81regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.02182039
82positive regulation of membrane potential (GO:0045838)3.01983270
83substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.01253893
84substrate-independent telencephalic tangential migration (GO:0021826)3.01253893
85cellular potassium ion homeostasis (GO:0030007)3.00753383
86transmission of nerve impulse (GO:0019226)2.99871947
87long-term memory (GO:0007616)2.98982355
88regulation of excitatory postsynaptic membrane potential (GO:0060079)2.98948103
89positive regulation of mitochondrial fission (GO:0090141)2.98777665
90neuromuscular synaptic transmission (GO:0007274)2.98398692
91cerebral cortex radially oriented cell migration (GO:0021799)2.97550885
92retinal ganglion cell axon guidance (GO:0031290)2.97549728
93camera-type eye morphogenesis (GO:0048593)2.96069411
94regulation of synapse maturation (GO:0090128)2.95014507
95negative regulation of astrocyte differentiation (GO:0048712)2.94964581
96gamma-aminobutyric acid signaling pathway (GO:0007214)2.93941086
97sodium ion export (GO:0071436)2.93701029
98synaptic vesicle endocytosis (GO:0048488)2.93691570
99establishment of nucleus localization (GO:0040023)2.93138936
100potassium ion import (GO:0010107)2.92264185
101somite development (GO:0061053)2.92251756
102heparin metabolic process (GO:0030202)2.91312799
103heparin biosynthetic process (GO:0030210)2.91312799
104neuron projection extension (GO:1990138)2.90729958
105response to auditory stimulus (GO:0010996)2.90557796
106central nervous system neuron differentiation (GO:0021953)2.89003784
107cornea development in camera-type eye (GO:0061303)2.87404802
108regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.85270348
109heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.84233923
110regulation of synapse assembly (GO:0051963)2.82761212
111regulation of timing of cell differentiation (GO:0048505)2.82242230
112left/right pattern formation (GO:0060972)2.82186338
113dendrite development (GO:0016358)2.82160401
114protein localization to cilium (GO:0061512)2.82029519
115appendage development (GO:0048736)2.81733518
116limb development (GO:0060173)2.81733518
117neuron-neuron synaptic transmission (GO:0007270)2.81149950
118cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.79509460
119proline transport (GO:0015824)2.78119187
120cranial nerve structural organization (GO:0021604)2.77626176
121regulation of glycogen (starch) synthase activity (GO:2000465)2.76858366
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.75732534
123negative regulation of catenin import into nucleus (GO:0035414)2.75639410
124regulation of axon guidance (GO:1902667)2.75405370
125regulation of postsynaptic membrane potential (GO:0060078)2.75166244
126positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.75161075
127synaptic vesicle exocytosis (GO:0016079)2.75116136
128dendritic spine organization (GO:0097061)2.73541585
129establishment of planar polarity (GO:0001736)2.72990279
130establishment of tissue polarity (GO:0007164)2.72990279
131axon ensheathment in central nervous system (GO:0032291)2.71065002
132central nervous system myelination (GO:0022010)2.71065002
133negative regulation of Ras GTPase activity (GO:0034261)2.70764420
134membrane depolarization (GO:0051899)2.70435562
135regulation of dendritic spine morphogenesis (GO:0061001)2.69617238
136synapse organization (GO:0050808)2.69328988
137neurotransmitter transport (GO:0006836)2.66895688
138regulation of development, heterochronic (GO:0040034)2.66700148
139neuron projection morphogenesis (GO:0048812)2.65083146
140regulation of synapse organization (GO:0050807)2.65036539
141cochlea development (GO:0090102)2.64879281
142regulation of smoothened signaling pathway (GO:0008589)2.64751082
143cerebral cortex neuron differentiation (GO:0021895)2.64517456
144regulation of neuronal synaptic plasticity (GO:0048168)2.64132148
145retina layer formation (GO:0010842)2.63816702
146regulation of respiratory system process (GO:0044065)2.62280183
147radial glial cell differentiation (GO:0060019)2.62176294
148negative regulation of synaptic transmission, GABAergic (GO:0032229)2.61061186

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.57436626
2* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.35362345
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15115438
4* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse3.10277396
5* EED_16625203_ChIP-ChIP_MESCs_Mouse3.06430335
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04429354
7RNF2_18974828_ChIP-Seq_MESCs_Mouse3.02328551
8EZH2_18974828_ChIP-Seq_MESCs_Mouse3.02328551
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.92764073
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.83044015
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65925820
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.65595340
13GBX2_23144817_ChIP-Seq_PC3_Human2.64799471
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61862999
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.56916867
16* EZH2_27294783_Chip-Seq_ESCs_Mouse2.56030374
17* RNF2_27304074_Chip-Seq_ESCs_Mouse2.52353539
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45948875
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41966109
20* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.35632830
21* CBX2_27304074_Chip-Seq_ESCs_Mouse2.33386393
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25470386
23DROSHA_22980978_ChIP-Seq_HELA_Human2.21305142
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09217115
25* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.04827275
26* REST_21632747_ChIP-Seq_MESCs_Mouse2.03930696
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96098111
28* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95167285
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84649157
30TAF15_26573619_Chip-Seq_HEK293_Human1.76234218
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75045810
32RING1B_27294783_Chip-Seq_ESCs_Mouse1.74716415
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68909202
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.68491343
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65385387
36* TP53_20018659_ChIP-ChIP_R1E_Mouse1.60611752
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58150600
38IGF1R_20145208_ChIP-Seq_DFB_Human1.55387910
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53126526
40* RNF2_27304074_Chip-Seq_NSC_Mouse1.52907301
41* RING1B_27294783_Chip-Seq_NPCs_Mouse1.50436018
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49513549
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.48484240
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47356763
45ZNF274_21170338_ChIP-Seq_K562_Hela1.46778763
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42178335
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39971534
48* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35598838
49SMAD4_21799915_ChIP-Seq_A2780_Human1.34724060
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33959761
51IRF1_19129219_ChIP-ChIP_H3396_Human1.29846450
52RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29313943
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28844823
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.27234313
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.27144388
56KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26675477
57P300_19829295_ChIP-Seq_ESCs_Human1.25788065
58* ERG_21242973_ChIP-ChIP_JURKAT_Human1.24684342
59* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22195777
60* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22195777
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22154689
62* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19487761
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19124706
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.15420538
65AR_21572438_ChIP-Seq_LNCaP_Human1.13157697
66* AR_19668381_ChIP-Seq_PC3_Human1.11889542
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.11617866
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11090970
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09319676
70FUS_26573619_Chip-Seq_HEK293_Human1.08600669
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08497640
72STAT3_23295773_ChIP-Seq_U87_Human1.08107166
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07898568
74* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07706164
75* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06910449
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06735502
77OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06394583
78CTCF_27219007_Chip-Seq_Bcells_Human1.06288629
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05103156
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04285348
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04119948
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03791048
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03289405
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03237617
85RUNX2_22187159_ChIP-Seq_PCA_Human1.02649292
86BCAT_22108803_ChIP-Seq_LS180_Human1.02035315
87RARB_27405468_Chip-Seq_BRAIN_Mouse1.00878593
88* SOX2_21211035_ChIP-Seq_LN229_Gbm1.00841064
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00670588
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.00396790
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99211099
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98747230
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.98410447
94AR_25329375_ChIP-Seq_VCAP_Human0.98321552
95* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97698548
96DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97522815
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97124681
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96802502
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96763031
100KDM2B_26808549_Chip-Seq_K562_Human0.96610686
101ISL1_27105846_Chip-Seq_CPCs_Mouse0.96496038
102LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95854767
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94147231
104ER_23166858_ChIP-Seq_MCF-7_Human0.93224227
105EWS_26573619_Chip-Seq_HEK293_Human0.93199343
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92832132
107PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92782057
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92095583
109* SOX2_16153702_ChIP-ChIP_HESCs_Human0.91032547
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90701200
111* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90148738
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90044479
113TCF4_23295773_ChIP-Seq_U87_Human0.89157158
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88824964
115POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88821941
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88154208
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87902720
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.87778344
119ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86499365
120SOX9_26525672_Chip-Seq_HEART_Mouse0.86274906
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86088363
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84654040
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.84584836
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.84561992
125PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84514440
126ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84160972
127ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83611569
128ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83390892

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.55104921
2MP0005423_abnormal_somatic_nervous3.47618893
3MP0009046_muscle_twitch3.13238522
4MP0003880_abnormal_central_pattern3.13092104
5MP0002938_white_spotting2.99130181
6MP0003635_abnormal_synaptic_transmissio2.86649338
7MP0000778_abnormal_nervous_system2.65181139
8MP0003136_yellow_coat_color2.55634853
9MP0002653_abnormal_ependyma_morphology2.44394529
10MP0003787_abnormal_imprinting2.43387146
11MP0002184_abnormal_innervation2.33602923
12MP0001968_abnormal_touch/_nociception2.28193641
13MP0001486_abnormal_startle_reflex2.26358690
14MP0008569_lethality_at_weaning2.24101147
15MP0009745_abnormal_behavioral_response2.17190885
16MP0005187_abnormal_penis_morphology2.16828106
17MP0006276_abnormal_autonomic_nervous2.15579875
18* MP0002067_abnormal_sensory_capabilities2.14678625
19MP0002734_abnormal_mechanical_nocicepti2.14273809
20MP0006292_abnormal_olfactory_placode2.13418182
21MP0000537_abnormal_urethra_morphology2.09703870
22MP0004270_analgesia2.04530028
23MP0002064_seizures2.04044446
24MP0003121_genomic_imprinting2.03812247
25MP0001440_abnormal_grooming_behavior2.00475907
26MP0002063_abnormal_learning/memory/cond1.99246327
27MP0004142_abnormal_muscle_tone1.94295189
28MP0002272_abnormal_nervous_system1.93837042
29MP0001984_abnormal_olfaction1.93058128
30MP0002572_abnormal_emotion/affect_behav1.91815898
31MP0005257_abnormal_intraocular_pressure1.89852195
32MP0004742_abnormal_vestibular_system1.86943997
33MP0005646_abnormal_pituitary_gland1.84909307
34MP0004133_heterotaxia1.82631018
35MP0003123_paternal_imprinting1.81974875
36MP0002557_abnormal_social/conspecific_i1.80393617
37MP0000955_abnormal_spinal_cord1.79887455
38MP0001529_abnormal_vocalization1.78033380
39MP0003938_abnormal_ear_development1.75629819
40MP0002736_abnormal_nociception_after1.72417291
41MP0001502_abnormal_circadian_rhythm1.56093964
42MP0002638_abnormal_pupillary_reflex1.53385977
43MP0002733_abnormal_thermal_nociception1.52553949
44MP0000631_abnormal_neuroendocrine_gland1.51859930
45MP0002234_abnormal_pharynx_morphology1.50688275
46MP0004885_abnormal_endolymph1.48792386
47MP0004145_abnormal_muscle_electrophysio1.48397488
48MP0005409_darkened_coat_color1.46811424
49MP0002282_abnormal_trachea_morphology1.45112645
50MP0002882_abnormal_neuron_morphology1.44722870
51MP0002735_abnormal_chemical_nociception1.39577141
52* MP0002152_abnormal_brain_morphology1.38561414
53MP0001299_abnormal_eye_distance/1.38015014
54MP0004924_abnormal_behavior1.32385242
55MP0005386_behavior/neurological_phenoty1.32385242
56MP0000751_myopathy1.29878699
57MP0002233_abnormal_nose_morphology1.29615687
58MP0006072_abnormal_retinal_apoptosis1.29385788
59MP0000579_abnormal_nail_morphology1.28283602
60MP0001485_abnormal_pinna_reflex1.28039025
61MP0005377_hearing/vestibular/ear_phenot1.27035869
62MP0003878_abnormal_ear_physiology1.27035869
63MP0002102_abnormal_ear_morphology1.27032740
64MP0001188_hyperpigmentation1.25599230
65MP0001970_abnormal_pain_threshold1.24648689
66MP0001501_abnormal_sleep_pattern1.22328113
67MP0009379_abnormal_foot_pigmentation1.21734722
68MP0010030_abnormal_orbit_morphology1.21599069
69MP0000049_abnormal_middle_ear1.21367036
70* MP0003861_abnormal_nervous_system1.21193958
71MP0000428_abnormal_craniofacial_morphol1.17724896
72MP0004811_abnormal_neuron_physiology1.16660072
73MP0003385_abnormal_body_wall1.16414733
74MP0005171_absent_coat_pigmentation1.15945288
75MP0003137_abnormal_impulse_conducting1.15512928
76MP0000026_abnormal_inner_ear1.15088986
77* MP0002066_abnormal_motor_capabilities/c1.12792492
78MP0002752_abnormal_somatic_nervous1.12259251
79MP0009250_abnormal_appendicular_skeleto1.08670489
80MP0000569_abnormal_digit_pigmentation1.08234348
81MP0004858_abnormal_nervous_system1.07688211
82MP0002932_abnormal_joint_morphology1.07305439
83MP0008877_abnormal_DNA_methylation1.06456277
84MP0005623_abnormal_meninges_morphology1.05638695
85MP0002909_abnormal_adrenal_gland1.04271605
86MP0005499_abnormal_olfactory_system1.03086794
87MP0005394_taste/olfaction_phenotype1.03086794
88MP0009780_abnormal_chondrocyte_physiolo1.02017575
89MP0002249_abnormal_larynx_morphology1.01839503
90MP0003937_abnormal_limbs/digits/tail_de0.99940143
91MP0003890_abnormal_embryonic-extraembry0.99435531
92MP0000534_abnormal_ureter_morphology0.96712172
93MP0002116_abnormal_craniofacial_bone0.94234186
94MP0005248_abnormal_Harderian_gland0.93782454
95MP0003879_abnormal_hair_cell0.93704796
96MP0005195_abnormal_posterior_eye0.93020060
97MP0003122_maternal_imprinting0.92978539
98MP0003942_abnormal_urinary_system0.92970464
99MP0001963_abnormal_hearing_physiology0.90479856
100MP0001293_anophthalmia0.89535348
101MP0004147_increased_porphyrin_level0.87099214
102MP0003632_abnormal_nervous_system0.85995491
103MP0001286_abnormal_eye_development0.85910723
104MP0003329_amyloid_beta_deposits0.84967868
105MP0002177_abnormal_outer_ear0.84738268
106MP0000566_synostosis0.84526481
107MP0005551_abnormal_eye_electrophysiolog0.84096046
108MP0002089_abnormal_postnatal_growth/wei0.83768206
109MP0003755_abnormal_palate_morphology0.83093703
110MP0005253_abnormal_eye_physiology0.82478184
111MP0003690_abnormal_glial_cell0.79992783
112MP0001346_abnormal_lacrimal_gland0.78731087
113MP0005645_abnormal_hypothalamus_physiol0.78375545
114MP0002009_preneoplasia0.78262101
115MP0000647_abnormal_sebaceous_gland0.78006821
116MP0005503_abnormal_tendon_morphology0.75097860
117MP0005391_vision/eye_phenotype0.74909180
118MP0008789_abnormal_olfactory_epithelium0.74491669
119MP0002081_perinatal_lethality0.73656366
120MP0004484_altered_response_of0.73262541
121MP0002114_abnormal_axial_skeleton0.72593922
122MP0003633_abnormal_nervous_system0.71350980
123MP0003935_abnormal_craniofacial_develop0.71177139
124MP0003119_abnormal_digestive_system0.69474520
125MP0000427_abnormal_hair_cycle0.69259289
126MP0000383_abnormal_hair_follicle0.67319441
127MP0002697_abnormal_eye_size0.66853121
128MP0003283_abnormal_digestive_organ0.65359912

Predicted human phenotypes

RankGene SetZ-score
1Abdominal situs inversus (HP:0003363)4.40570459
2Abnormality of abdominal situs (HP:0011620)4.40570459
3Abnormality of the nasal septum (HP:0000419)3.88214791
4Trigonocephaly (HP:0000243)3.80118221
5Hemiparesis (HP:0001269)3.74221756
6Focal motor seizures (HP:0011153)3.71909666
7Action tremor (HP:0002345)3.71045618
8Short 4th metacarpal (HP:0010044)3.68727603
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.68727603
10Progressive cerebellar ataxia (HP:0002073)3.53418605
11Abnormality of the diencephalon (HP:0010662)3.51200087
12Gait imbalance (HP:0002141)3.48745978
13Humeroradial synostosis (HP:0003041)3.47899030
14Synostosis involving the elbow (HP:0003938)3.47899030
15True hermaphroditism (HP:0010459)3.34705606
16Aplasia of the phalanges of the hand (HP:0009802)3.30763878
17Aplasia involving bones of the extremities (HP:0009825)3.30763878
18Aplasia involving bones of the upper limbs (HP:0009823)3.30763878
19Midline defect of the nose (HP:0004122)3.30732166
20Oligodactyly (HP:0012165)3.28112241
21Pancreatic fibrosis (HP:0100732)3.27433240
22Abnormality of the parietal bone (HP:0002696)3.23720714
23Broad-based gait (HP:0002136)3.08953755
24Congenital primary aphakia (HP:0007707)3.02827597
25Oligodactyly (hands) (HP:0001180)3.02195815
26Focal seizures (HP:0007359)2.99843406
27Febrile seizures (HP:0002373)2.94353281
28Medial flaring of the eyebrow (HP:0010747)2.91581171
29Gaze-evoked nystagmus (HP:0000640)2.89373357
30Pancreatic cysts (HP:0001737)2.85771386
31Hyperacusis (HP:0010780)2.84490489
32Neoplasm of the heart (HP:0100544)2.84367073
33Renal duplication (HP:0000075)2.83815227
34Supernumerary spleens (HP:0009799)2.78063789
35Elfin facies (HP:0004428)2.77884360
36Overriding aorta (HP:0002623)2.75517397
37Nephrogenic diabetes insipidus (HP:0009806)2.73126944
38Myokymia (HP:0002411)2.71128103
39Abnormality of midbrain morphology (HP:0002418)2.69786593
40Molar tooth sign on MRI (HP:0002419)2.69786593
41Abnormality of the proximal phalanges of the hand (HP:0009834)2.65101896
42Cystic liver disease (HP:0006706)2.61500346
43Morphological abnormality of the middle ear (HP:0008609)2.61002434
44Postaxial foot polydactyly (HP:0001830)2.60811432
45Abnormal respiratory motile cilium physiology (HP:0012261)2.60005099
46Nephronophthisis (HP:0000090)2.53403618
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.52722783
48Hemiplegia (HP:0002301)2.52387127
49Insomnia (HP:0100785)2.52331287
50Renovascular hypertension (HP:0100817)2.52113062
51Abnormality of the aortic arch (HP:0012303)2.51622224
52Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.51539045
53Vaginal atresia (HP:0000148)2.50671432
54Abnormality of the 4th metacarpal (HP:0010012)2.48507809
55Shallow orbits (HP:0000586)2.48265319
56Abnormality of the middle phalanges of the toes (HP:0010183)2.48075335
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.45947418
58Genital tract atresia (HP:0001827)2.43381345
59Rib fusion (HP:0000902)2.39415974
60Scanning speech (HP:0002168)2.38403094
61Short phalanx of the thumb (HP:0009660)2.37159678
62Anencephaly (HP:0002323)2.34814767
63Annular pancreas (HP:0001734)2.33989790
64Megalencephaly (HP:0001355)2.32060690
65Poor coordination (HP:0002370)2.30810031
66Cutaneous finger syndactyly (HP:0010554)2.29584610
67Postaxial hand polydactyly (HP:0001162)2.29058806
68Flat cornea (HP:0007720)2.28744125
69Fibular hypoplasia (HP:0003038)2.27462929
70Dysdiadochokinesis (HP:0002075)2.27361885
71Nonprogressive disorder (HP:0003680)2.27219608
72Short hallux (HP:0010109)2.26608746
73Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.24878294
74Status epilepticus (HP:0002133)2.24180580
75Long nose (HP:0003189)2.20556763
76Sleep apnea (HP:0010535)2.17242381
77Abnormal eating behavior (HP:0100738)2.16486974
78Anteriorly placed anus (HP:0001545)2.16214755
79Aplasia/Hypoplasia of the spleen (HP:0010451)2.14519765
80Chronic hepatic failure (HP:0100626)2.13354352
81Anophthalmia (HP:0000528)2.12806560
82Facial hemangioma (HP:0000329)2.11983821
83Specific learning disability (HP:0001328)2.11932166
84Abnormal number of incisors (HP:0011064)2.11925434
85Mesomelia (HP:0003027)2.11212501
86Truncal ataxia (HP:0002078)2.10527411
87Depressed nasal tip (HP:0000437)2.09587228
88Abnormality of the lower motor neuron (HP:0002366)2.05904729
89Abnormal ciliary motility (HP:0012262)2.05028597
90High anterior hairline (HP:0009890)2.04298459
91Abnormality of the phalanges of the 5th finger (HP:0004213)2.04192424
92Cutaneous syndactyly (HP:0012725)2.04105355
93Symphalangism affecting the phalanges of the hand (HP:0009773)2.03819126
94Epileptic encephalopathy (HP:0200134)2.02931467
95Progressive inability to walk (HP:0002505)2.02883682
96Spinal canal stenosis (HP:0003416)2.02459292
97Polyphagia (HP:0002591)2.01927673
98Turricephaly (HP:0000262)2.01653602
99Abnormality of the middle phalanges of the hand (HP:0009833)2.01473592
100Aqueductal stenosis (HP:0002410)2.00997181
101Asplenia (HP:0001746)1.99641359
102Aplasia/Hypoplasia of the hallux (HP:0008362)1.99170493
103Abnormality of the columella (HP:0009929)1.98715971
104Concave nail (HP:0001598)1.97717619
105Excessive salivation (HP:0003781)1.96349504
106Drooling (HP:0002307)1.96349504
107Abnormality of the renal medulla (HP:0100957)1.94764395
108Abnormality of the corticospinal tract (HP:0002492)1.92599551
109Broad metatarsal (HP:0001783)1.91571718
110Atonic seizures (HP:0010819)1.91269326
111Diplopia (HP:0000651)1.91171525
112Abnormality of binocular vision (HP:0011514)1.91171525
113Visual hallucinations (HP:0002367)1.90527565
114Aplasia/Hypoplasia of the breasts (HP:0010311)1.90370141
115Broad finger (HP:0001500)1.88895821
116Preaxial hand polydactyly (HP:0001177)1.88753443
117Hypoplastic nipples (HP:0002557)1.88364838
118Amblyopia (HP:0000646)1.87756310
119Papilledema (HP:0001085)1.87138206
120Holoprosencephaly (HP:0001360)1.87060818
121Hyperglycinemia (HP:0002154)1.86695501
122Pointed chin (HP:0000307)1.86559291
123Agitation (HP:0000713)1.86350503
124Narrow forehead (HP:0000341)1.84703645
125Breast aplasia (HP:0100783)1.84150017
126Generalized tonic-clonic seizures (HP:0002069)1.83603879
127Hypoplasia of the brainstem (HP:0002365)1.83058805
128Aplasia/Hypoplasia of the brainstem (HP:0007362)1.83058805
129Aplasia/Hypoplasia of the sternum (HP:0006714)1.81759053
130Spastic gait (HP:0002064)1.81217919
131Abnormal respiratory epithelium morphology (HP:0012253)1.81052229
132Abnormal respiratory motile cilium morphology (HP:0005938)1.81052229
133Supernumerary ribs (HP:0005815)1.80738812
134Limb dystonia (HP:0002451)1.80446144
135Micropenis (HP:0000054)1.80261351
136Down-sloping shoulders (HP:0200021)1.80031377
137Aplasia/Hypoplasia of the lens (HP:0008063)1.79849834
138Septo-optic dysplasia (HP:0100842)1.78611188
139Broad phalanx (HP:0006009)1.77840935
140Decreased testicular size (HP:0008734)1.77730595
141Median cleft lip (HP:0000161)1.77556244
142Narrow nasal bridge (HP:0000446)1.77476304
143Type II lissencephaly (HP:0007260)1.76776391
144Blue irides (HP:0000635)1.76030717
145Broad foot (HP:0001769)1.75908562
146Absent septum pellucidum (HP:0001331)1.75125723
147Adrenal hypoplasia (HP:0000835)1.74918211
148Congenital hepatic fibrosis (HP:0002612)1.74219811
149Obstructive sleep apnea (HP:0002870)1.73388581
150Morphological abnormality of the pyramidal tract (HP:0002062)1.72777782
151Infantile muscular hypotonia (HP:0008947)1.72756551
152Sclerocornea (HP:0000647)1.72132187
153Optic nerve hypoplasia (HP:0000609)1.71821723
154Broad phalanges of the hand (HP:0009768)1.71790748
155Genetic anticipation (HP:0003743)1.71481260
156Lissencephaly (HP:0001339)1.70746068
157Abnormal ventriculo-arterial connection (HP:0011563)1.70502911
158Transposition of the great arteries (HP:0001669)1.70502911
159Abnormal connection of the cardiac segments (HP:0011545)1.70502911
160Increased nuchal translucency (HP:0010880)1.69803509
161Macrotia (HP:0000400)1.67792251
162Macroorchidism (HP:0000053)1.67513179
163Omphalocele (HP:0001539)1.66364527
164Germ cell neoplasia (HP:0100728)1.66198124
165Absent speech (HP:0001344)1.65135743
166Supernumerary bones of the axial skeleton (HP:0009144)1.65039429
167Depression (HP:0000716)1.64454489
168Aplasia cutis congenita (HP:0001057)1.63556862
169Narrow palate (HP:0000189)1.63282319
170Postural tremor (HP:0002174)1.62735103
171Alacrima (HP:0000522)1.61822594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.11659798
2TNIK3.90492880
3CASK3.00832005
4NTRK32.88387850
5MUSK2.68179019
6MAPK132.51090044
7NTRK22.47336708
8MAP2K72.41730071
9MAP3K42.31010661
10SIK21.96843025
11WNK31.88874655
12TRIM281.87132584
13CAMKK21.79132888
14MKNK21.79115034
15EPHB21.78002638
16STK111.74715165
17MAP4K21.74269506
18MAP3K91.72483315
19CDK191.69194535
20PRKD31.69036415
21PNCK1.63733541
22UHMK11.61882387
23PLK21.59504330
24MINK11.52682324
25DAPK21.52563671
26BCKDK1.49233774
27MKNK11.49229618
28PHKG21.30709400
29PHKG11.30709400
30HIPK21.27815603
31ERBB31.27472791
32SRPK11.24125600
33CAMK1G1.23922152
34CAMKK11.17154918
35SGK21.14647174
36SGK2231.13770805
37SGK4941.13770805
38MAP2K41.07578949
39KSR11.03656759
40CDK51.03270976
41WNK41.02315372
42DYRK21.01497163
43MAPK151.01367948
44PRKCG1.01192254
45DYRK1A1.00333454
46IRAK20.99954775
47INSRR0.96231241
48PAK60.95756141
49ERBB20.92410454
50PKN10.90011931
51FGFR20.88243319
52CAMK40.86462469
53MAP3K60.85689710
54CSNK1A1L0.84821895
55ICK0.84517120
56PDGFRA0.83725739
57WNK10.82763151
58SGK30.82078215
59CAMK2A0.81944870
60SIK10.80676721
61ALK0.77863064
62STK380.77545897
63CSNK1G10.77442972
64PRKG10.76082005
65CDC42BPA0.75188531
66ROCK20.74384082
67CSNK1G20.74370282
68ROCK10.73760935
69YES10.73440605
70ADRBK20.73207281
71RIPK10.71951659
72DYRK30.70954114
73CSNK1G30.70676369
74LIMK10.69609727
75ADRBK10.68311201
76RPS6KA20.66415826
77TNK20.66246785
78MAPKAPK50.65970061
79CAMK2B0.65458135
80PAK30.64950303
81PRKCZ0.64488619
82CAMK10.64360392
83PTK60.63606830
84CDK150.63012238
85NTRK10.62261823
86FGFR10.61921604
87EIF2AK20.61049034
88CDK80.61003915
89BCR0.60328584
90MAP3K70.60232637
91FER0.60050749
92CDK30.59941403
93GRK50.59300130
94CDK180.58424634
95MAPK90.57306642
96CDK11A0.56932404
97PRKCH0.56425974
98CDK140.55201275
99FES0.54479564
100RET0.54114672
101RPS6KA40.52811007
102EPHA30.52337992
103PINK10.51991831
104SGK10.50672447
105EPHA40.49572720
106DYRK1B0.48513306
107MARK20.47089388
108OXSR10.47080031
109GRK10.46663157
110BMPR1B0.45765649
111NUAK10.45702318
112MAP3K110.44896823
113PRKDC0.44795740
114BMX0.44264770
115PRKAA10.43808173
116TIE10.43181576
117BRD40.43055532
118DMPK0.42928437
119AKT20.42504353
120PRKACA0.42482936
121TYRO30.41083156
122MAPK100.40841499
123RPS6KA30.40330581
124CSNK1A10.40327735
125FGR0.40246335
126PRKCE0.39828182
127CSNK1E0.35344350
128CAMK2G0.34356130
129SRC0.34097076
130CAMK2D0.33641194

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.12869583
2Glutamatergic synapse_Homo sapiens_hsa047242.74755718
3GABAergic synapse_Homo sapiens_hsa047272.63029038
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54268390
5Morphine addiction_Homo sapiens_hsa050322.47406001
6Hedgehog signaling pathway_Homo sapiens_hsa043402.46466876
7Circadian entrainment_Homo sapiens_hsa047132.38836511
8Basal cell carcinoma_Homo sapiens_hsa052172.24804622
9Taste transduction_Homo sapiens_hsa047422.12651071
10Steroid biosynthesis_Homo sapiens_hsa001001.99477816
11Long-term depression_Homo sapiens_hsa047301.93244806
12Salivary secretion_Homo sapiens_hsa049701.90551621
13Synaptic vesicle cycle_Homo sapiens_hsa047211.90221295
14Long-term potentiation_Homo sapiens_hsa047201.86591304
15Olfactory transduction_Homo sapiens_hsa047401.80354834
16Axon guidance_Homo sapiens_hsa043601.79202297
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79093846
18Dopaminergic synapse_Homo sapiens_hsa047281.58905124
19Gastric acid secretion_Homo sapiens_hsa049711.57724697
20Cholinergic synapse_Homo sapiens_hsa047251.54832823
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49387497
22Amphetamine addiction_Homo sapiens_hsa050311.48802078
23Gap junction_Homo sapiens_hsa045401.48231943
24Serotonergic synapse_Homo sapiens_hsa047261.45780836
25Melanogenesis_Homo sapiens_hsa049161.45548514
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43831551
27Renin secretion_Homo sapiens_hsa049241.43259177
28Wnt signaling pathway_Homo sapiens_hsa043101.41956065
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39602171
30Calcium signaling pathway_Homo sapiens_hsa040201.36341174
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33155508
32Insulin secretion_Homo sapiens_hsa049111.33047409
33cAMP signaling pathway_Homo sapiens_hsa040241.30721330
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.29113631
35Oxidative phosphorylation_Homo sapiens_hsa001901.27040597
36Oxytocin signaling pathway_Homo sapiens_hsa049211.23612346
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23014957
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19080928
39GnRH signaling pathway_Homo sapiens_hsa049121.18226385
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12957554
41Cocaine addiction_Homo sapiens_hsa050301.12469998
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12355833
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11021651
44Parkinsons disease_Homo sapiens_hsa050121.10964140
45Nitrogen metabolism_Homo sapiens_hsa009101.10130671
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09512395
47Ribosome_Homo sapiens_hsa030101.09246253
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08919687
49Cardiac muscle contraction_Homo sapiens_hsa042601.08902986
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07709554
51Linoleic acid metabolism_Homo sapiens_hsa005911.06780309
52Type II diabetes mellitus_Homo sapiens_hsa049301.05776697
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05324330
54Phospholipase D signaling pathway_Homo sapiens_hsa040721.04562440
55Estrogen signaling pathway_Homo sapiens_hsa049151.04354570
56Colorectal cancer_Homo sapiens_hsa052101.02580534
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99415323
58Butanoate metabolism_Homo sapiens_hsa006500.98062596
59Choline metabolism in cancer_Homo sapiens_hsa052310.97885861
60Dilated cardiomyopathy_Homo sapiens_hsa054140.97194556
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97126551
62Propanoate metabolism_Homo sapiens_hsa006400.96812219
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96655908
64Alzheimers disease_Homo sapiens_hsa050100.96647129
65Huntingtons disease_Homo sapiens_hsa050160.94542496
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94531738
67Endometrial cancer_Homo sapiens_hsa052130.93803376
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92940168
69Hippo signaling pathway_Homo sapiens_hsa043900.92795274
70ErbB signaling pathway_Homo sapiens_hsa040120.91999769
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91395539
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90356010
73Arginine and proline metabolism_Homo sapiens_hsa003300.90090994
74Glioma_Homo sapiens_hsa052140.88879642
75Melanoma_Homo sapiens_hsa052180.79112449
76Pancreatic secretion_Homo sapiens_hsa049720.76024642
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75858089
78MAPK signaling pathway_Homo sapiens_hsa040100.74099546
79Rap1 signaling pathway_Homo sapiens_hsa040150.72254966
80Protein export_Homo sapiens_hsa030600.71428399
81Alcoholism_Homo sapiens_hsa050340.70571858
82Ovarian steroidogenesis_Homo sapiens_hsa049130.70428146
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68161817
84Proteoglycans in cancer_Homo sapiens_hsa052050.67186498
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67080217
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.66896830
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66172888
88Phototransduction_Homo sapiens_hsa047440.65277261
89Thyroid hormone synthesis_Homo sapiens_hsa049180.64891703
90Circadian rhythm_Homo sapiens_hsa047100.64488024
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.61706708
92Pathways in cancer_Homo sapiens_hsa052000.61361643
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61319241
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61203750
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60780215
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58423188
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58181692
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.58145930
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57659948
100Dorso-ventral axis formation_Homo sapiens_hsa043200.56097367
101Ras signaling pathway_Homo sapiens_hsa040140.55064261
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54723529
103Ether lipid metabolism_Homo sapiens_hsa005650.54438656
104Peroxisome_Homo sapiens_hsa041460.52896218
105Renal cell carcinoma_Homo sapiens_hsa052110.52327475
106Inositol phosphate metabolism_Homo sapiens_hsa005620.51474908
107Oocyte meiosis_Homo sapiens_hsa041140.49663846
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49657908
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48780532
110mRNA surveillance pathway_Homo sapiens_hsa030150.48109934
111Bile secretion_Homo sapiens_hsa049760.47650132
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47208551
113Non-small cell lung cancer_Homo sapiens_hsa052230.46537941
114ECM-receptor interaction_Homo sapiens_hsa045120.45469509
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45066944
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44326930
117Tight junction_Homo sapiens_hsa045300.43520076
118Collecting duct acid secretion_Homo sapiens_hsa049660.42879612
119Fatty acid metabolism_Homo sapiens_hsa012120.42740438
120Amoebiasis_Homo sapiens_hsa051460.41328283
121beta-Alanine metabolism_Homo sapiens_hsa004100.41266094
122Focal adhesion_Homo sapiens_hsa045100.41196294
123Mineral absorption_Homo sapiens_hsa049780.40836737
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39488184
125Fat digestion and absorption_Homo sapiens_hsa049750.39354713
126Protein digestion and absorption_Homo sapiens_hsa049740.39210194
127Notch signaling pathway_Homo sapiens_hsa043300.39140172
128Biosynthesis of amino acids_Homo sapiens_hsa012300.37723426
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36841812
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36443969
131MicroRNAs in cancer_Homo sapiens_hsa052060.32279365
132Platelet activation_Homo sapiens_hsa046110.32021204

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