ZIC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. The encoded protein may act as a transcriptional repressor. Studies in mouse and Xenopus support a role for this gene in neural crest development. Elevated expression of this gene has been observed in various human cancers and may contribute to cancer progression. This gene is closely linked to a related family member on chromosome 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)5.19354029
2regulation of gene silencing by miRNA (GO:0060964)5.19354029
3regulation of gene silencing by RNA (GO:0060966)5.19354029
4paraxial mesoderm development (GO:0048339)4.88909735
5nuclear pore organization (GO:0006999)4.41296362
6regulation of nuclear cell cycle DNA replication (GO:0033262)4.40116553
7nuclear pore complex assembly (GO:0051292)4.18908304
8mitotic metaphase plate congression (GO:0007080)4.14685171
9DNA unwinding involved in DNA replication (GO:0006268)3.97723309
10kinetochore organization (GO:0051383)3.97215341
11kinetochore assembly (GO:0051382)3.91284543
12pre-miRNA processing (GO:0031054)3.86307398
13L-serine metabolic process (GO:0006563)3.71565515
14regulation of histone H3-K9 methylation (GO:0051570)3.67328171
15somatic hypermutation of immunoglobulin genes (GO:0016446)3.64536531
16somatic diversification of immune receptors via somatic mutation (GO:0002566)3.64536531
17chromatin remodeling at centromere (GO:0031055)3.63665157
18regulation of helicase activity (GO:0051095)3.63457984
19cell migration involved in gastrulation (GO:0042074)3.62893561
20negative regulation of histone methylation (GO:0031061)3.59410398
21metaphase plate congression (GO:0051310)3.57042015
22notochord development (GO:0030903)3.52196237
23negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.51966685
24histone arginine methylation (GO:0034969)3.51145115
25regulation of double-strand break repair via homologous recombination (GO:0010569)3.46954241
26DNA strand renaturation (GO:0000733)3.45513108
27DNA replication-dependent nucleosome assembly (GO:0006335)3.42999735
28DNA replication-dependent nucleosome organization (GO:0034723)3.42999735
29CENP-A containing nucleosome assembly (GO:0034080)3.42228091
30DNA replication initiation (GO:0006270)3.39404538
31establishment of integrated proviral latency (GO:0075713)3.37079200
32IMP biosynthetic process (GO:0006188)3.36507357
33heterochromatin organization (GO:0070828)3.36360527
34ribosome biogenesis (GO:0042254)3.31687702
35histone H4-K12 acetylation (GO:0043983)3.30512859
36maturation of SSU-rRNA (GO:0030490)3.29297220
37regulation of centriole replication (GO:0046599)3.21409208
38anterior/posterior axis specification, embryo (GO:0008595)3.21276751
39mitotic sister chromatid segregation (GO:0000070)3.19594829
40peptidyl-arginine omega-N-methylation (GO:0035247)3.18975720
41positive regulation of DNA-dependent DNA replication (GO:2000105)3.18613812
42maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.16696394
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.16608010
44regulation of mitotic spindle checkpoint (GO:1903504)3.16608010
45pore complex assembly (GO:0046931)3.14646758
46histone exchange (GO:0043486)3.14449494
47negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.10065120
48DNA geometric change (GO:0032392)3.08619315
49regulation of gene silencing (GO:0060968)3.08167784
50DNA duplex unwinding (GO:0032508)3.06842730
51DNA replication-independent nucleosome organization (GO:0034724)3.06821653
52DNA replication-independent nucleosome assembly (GO:0006336)3.06821653
53replication fork processing (GO:0031297)3.06338872
54negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.06285945
55negative regulation of translation, ncRNA-mediated (GO:0040033)3.06285945
56regulation of translation, ncRNA-mediated (GO:0045974)3.06285945
57regulation of cell fate specification (GO:0042659)3.05030845
58regulation of telomere maintenance via telomerase (GO:0032210)3.04726619
59protein complex localization (GO:0031503)3.04541806
60mitotic nuclear envelope disassembly (GO:0007077)3.04005045
61protein localization to kinetochore (GO:0034501)3.02199215
62chaperone-mediated protein transport (GO:0072321)3.01845321
63chromatin assembly (GO:0031497)2.98144915
64purine nucleobase biosynthetic process (GO:0009113)2.97382347
65DNA strand elongation involved in DNA replication (GO:0006271)2.97334476
66sister chromatid segregation (GO:0000819)2.95002165
67DNA replication checkpoint (GO:0000076)2.94513799
68negative regulation of DNA-dependent DNA replication (GO:2000104)2.93883898
69spindle checkpoint (GO:0031577)2.92894949
70presynaptic membrane assembly (GO:0097105)2.92284744
71DNA ligation (GO:0006266)2.91934070
72establishment of chromosome localization (GO:0051303)2.91771822
73mitotic sister chromatid cohesion (GO:0007064)2.91517746
74DNA damage response, detection of DNA damage (GO:0042769)2.91399918
75peptidyl-arginine methylation (GO:0018216)2.88584313
76peptidyl-arginine N-methylation (GO:0035246)2.88584313
77regulation of double-strand break repair (GO:2000779)2.86428424
78telomere maintenance via semi-conservative replication (GO:0032201)2.85783898
79regulation of gene expression by genetic imprinting (GO:0006349)2.85420549
80mitotic spindle checkpoint (GO:0071174)2.84520595
81meiotic chromosome segregation (GO:0045132)2.84124379
82establishment of viral latency (GO:0019043)2.83949939
83viral mRNA export from host cell nucleus (GO:0046784)2.83941836
84negative regulation of chromosome segregation (GO:0051985)2.83071953
85ribosomal small subunit biogenesis (GO:0042274)2.82095600
86nucleobase biosynthetic process (GO:0046112)2.81913896
87DNA strand elongation (GO:0022616)2.81433145
88negative regulation of gene silencing (GO:0060969)2.81233379
89regulation of mesoderm development (GO:2000380)2.81117992
90lateral sprouting from an epithelium (GO:0060601)2.80870314
91regulation of centrosome cycle (GO:0046605)2.80640621
92cellular protein complex localization (GO:0034629)2.79555072
93nuclear envelope disassembly (GO:0051081)2.79008639
94membrane disassembly (GO:0030397)2.79008639
95histone H4-K5 acetylation (GO:0043981)2.78496715
96histone H4-K8 acetylation (GO:0043982)2.78496715
97termination of RNA polymerase II transcription (GO:0006369)2.78302632
98regulation of sister chromatid cohesion (GO:0007063)2.77972782
99ribosome assembly (GO:0042255)2.77825324
100lung-associated mesenchyme development (GO:0060484)2.76978027
101telomere maintenance via telomere lengthening (GO:0010833)2.76610205
102DNA topological change (GO:0006265)2.75968921
103protein localization to chromosome, centromeric region (GO:0071459)2.75523159
104mitotic recombination (GO:0006312)2.75336733
105regulation of chromosome segregation (GO:0051983)2.74586741
106embryonic process involved in female pregnancy (GO:0060136)2.74195290
107spliceosomal complex assembly (GO:0000245)2.73329585
108telomere maintenance via recombination (GO:0000722)2.73266318
109regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.72234608
110translational termination (GO:0006415)2.71454685
111ribosomal small subunit assembly (GO:0000028)2.70966930
112negative regulation of mitotic sister chromatid separation (GO:2000816)2.70945124
113negative regulation of mitotic sister chromatid segregation (GO:0033048)2.70945124
114negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.70945124
115negative regulation of sister chromatid segregation (GO:0033046)2.70945124
116spliceosomal snRNP assembly (GO:0000387)2.70905704
117mismatch repair (GO:0006298)2.70835026
118IMP metabolic process (GO:0046040)2.70119944
119pseudouridine synthesis (GO:0001522)2.69578550
120regulation of DNA-dependent DNA replication (GO:0090329)2.68967964
121chromatin assembly or disassembly (GO:0006333)2.68689938
122regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.68324219
123regulation of mitotic metaphase/anaphase transition (GO:0030071)2.68324219
124negative regulation of mitosis (GO:0045839)2.68103774
125negative regulation of telomerase activity (GO:0051974)2.67949516
126negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67847742
127ATP-dependent chromatin remodeling (GO:0043044)2.67811030
128nodal signaling pathway (GO:0038092)2.67799641
129establishment of protein localization to mitochondrial membrane (GO:0090151)2.67346244
130mitotic spindle assembly checkpoint (GO:0007094)2.66245410
131viral transcription (GO:0019083)2.65616982
132somite rostral/caudal axis specification (GO:0032525)2.65379079
133negative regulation of mRNA processing (GO:0050686)2.65343928
134outer ear morphogenesis (GO:0042473)2.65046407
135regulation of sister chromatid segregation (GO:0033045)2.64780050
136regulation of mitotic sister chromatid separation (GO:0010965)2.64780050
137regulation of mitotic sister chromatid segregation (GO:0033047)2.64780050
138convergent extension (GO:0060026)2.64301960
139mitotic chromosome condensation (GO:0007076)2.61911781
140spindle assembly checkpoint (GO:0071173)2.59949692
141negative regulation of RNA splicing (GO:0033119)2.59785879
142positive regulation of SMAD protein import into nucleus (GO:0060391)2.59576071
143DNA double-strand break processing (GO:0000729)2.59030633
144negative regulation of DNA recombination (GO:0045910)2.58034956
145otic vesicle formation (GO:0030916)2.55556519
146dorsal/ventral axis specification (GO:0009950)2.54798479
147serine family amino acid biosynthetic process (GO:0009070)2.54763662
148presynaptic membrane organization (GO:0097090)2.53935881

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.57690676
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.92676693
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.79164541
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.64980085
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.64980085
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.64980085
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.49891662
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.96445717
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93036488
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.86112637
11* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.74588911
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.69438068
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64531565
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.61921735
15* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.59476964
16* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.59377598
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54208609
18ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.52758020
19* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.52639834
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.52221677
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.51706946
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51203906
23SOX2_18555785_ChIP-Seq_MESCs_Mouse2.40627548
24* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.39383228
25* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.35737478
26* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.31622521
27* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.31123633
28SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.10455908
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07272250
30RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05867533
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03330066
32MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02915272
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99499658
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.96531358
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.89038417
36* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.88856917
37POU5F1_16518401_ChIP-PET_MESCs_Mouse1.81296086
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80540261
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68480844
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.68035033
41* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67494782
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67449583
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.64857076
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63180317
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61448049
46* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.60446186
47* EWS_26573619_Chip-Seq_HEK293_Human1.60073570
48ELK1_19687146_ChIP-ChIP_HELA_Human1.58400760
49KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.58011971
50* SOX2_16153702_ChIP-ChIP_HESCs_Human1.57908968
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57407718
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.56160533
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54797313
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54171194
55* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.53759685
56XRN2_22483619_ChIP-Seq_HELA_Human1.53416417
57FUS_26573619_Chip-Seq_HEK293_Human1.52410585
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52398886
59* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.52315727
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47710831
61TTF2_22483619_ChIP-Seq_HELA_Human1.47030310
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44352732
63* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.43575528
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.41217888
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.40765779
66* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.39886270
67* NANOG_16153702_ChIP-ChIP_HESCs_Human1.39036548
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38458180
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37446188
70* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.34699044
71AR_21909140_ChIP-Seq_LNCAP_Human1.33683952
72EZH2_22144423_ChIP-Seq_EOC_Human1.32506599
73* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.31569853
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28537261
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27205708
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.27126648
77* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.26110767
78* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22442133
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.22104347
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.21529265
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.21238250
82* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.17811632
83* NANOG_16518401_ChIP-PET_MESCs_Mouse1.17797900
84* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17422043
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12873891
86* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11826664
87* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11100430
88* MYC_18940864_ChIP-ChIP_HL60_Human1.10526543
89PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09401032
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09272638
91* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07236985
92* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07093867
93EGR1_19374776_ChIP-ChIP_THP-1_Human1.06279901
94JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05748207
95* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05464148
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03477154
97DCP1A_22483619_ChIP-Seq_HELA_Human1.01175184
98* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99463414
99RNF2_27304074_Chip-Seq_NSC_Mouse0.99302048
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98951514
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95170628
102CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92864659
103* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92763740
104IRF1_19129219_ChIP-ChIP_H3396_Human0.92691209
105GABP_19822575_ChIP-Seq_HepG2_Human0.92628255
106TAF15_26573619_Chip-Seq_HEK293_Human0.91703301
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91461326
108EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90285528
109HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90129732
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89644865
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89605163
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89605163
113P300_19829295_ChIP-Seq_ESCs_Human0.86633722
114FOXP3_21729870_ChIP-Seq_TREG_Human0.83455601
115KAP1_27257070_Chip-Seq_ESCs_Mouse0.80399517
116VDR_23849224_ChIP-Seq_CD4+_Human0.80388979
117* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80313361
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76822011
119* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.76691835
120KDM5A_27292631_Chip-Seq_BREAST_Human0.75518782
121* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74957028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry3.43537321
2MP0006292_abnormal_olfactory_placode3.41242345
3MP0003111_abnormal_nucleus_morphology3.04149839
4MP0004957_abnormal_blastocyst_morpholog2.94702507
5MP0010030_abnormal_orbit_morphology2.92249304
6MP0010094_abnormal_chromosome_stability2.86963400
7MP0004133_heterotaxia2.81684179
8MP0002653_abnormal_ependyma_morphology2.69455811
9MP0008057_abnormal_DNA_replication2.48873849
10MP0003693_abnormal_embryo_hatching2.47449110
11MP0008058_abnormal_DNA_repair2.40902344
12MP0008877_abnormal_DNA_methylation2.38059192
13MP0003077_abnormal_cell_cycle2.30196972
14MP0008789_abnormal_olfactory_epithelium2.16123125
15MP0005394_taste/olfaction_phenotype2.14715005
16MP0005499_abnormal_olfactory_system2.14715005
17MP0008007_abnormal_cellular_replicative2.11649086
18MP0008932_abnormal_embryonic_tissue2.06342208
19MP0003119_abnormal_digestive_system2.05572303
20MP0003941_abnormal_skin_development1.98007895
21MP0003136_yellow_coat_color1.95055558
22MP0003122_maternal_imprinting1.77162986
23MP0000350_abnormal_cell_proliferation1.74630160
24MP0003123_paternal_imprinting1.74392263
25MP0000049_abnormal_middle_ear1.73696637
26* MP0002085_abnormal_embryonic_tissue1.68445904
27* MP0001293_anophthalmia1.67904307
28MP0000579_abnormal_nail_morphology1.67462321
29MP0002084_abnormal_developmental_patter1.63562258
30MP0000566_synostosis1.63251856
31MP0001730_embryonic_growth_arrest1.63157241
32MP0001346_abnormal_lacrimal_gland1.61265565
33MP0002254_reproductive_system_inflammat1.59077077
34MP0005423_abnormal_somatic_nervous1.58365801
35MP0009379_abnormal_foot_pigmentation1.55979837
36MP0003315_abnormal_perineum_morphology1.55006601
37MP0001672_abnormal_embryogenesis/_devel1.54398594
38MP0005380_embryogenesis_phenotype1.54398594
39* MP0003861_abnormal_nervous_system1.50572356
40MP0002938_white_spotting1.49477610
41MP0001697_abnormal_embryo_size1.47756765
42MP0006072_abnormal_retinal_apoptosis1.46160390
43MP0005171_absent_coat_pigmentation1.42362741
44MP0004197_abnormal_fetal_growth/weight/1.41242940
45MP0003283_abnormal_digestive_organ1.40293258
46MP0001188_hyperpigmentation1.40200910
47MP0001529_abnormal_vocalization1.39640641
48MP0002249_abnormal_larynx_morphology1.38928641
49MP0000516_abnormal_urinary_system1.38704857
50MP0005367_renal/urinary_system_phenotyp1.38704857
51MP0003121_genomic_imprinting1.35978189
52MP0005377_hearing/vestibular/ear_phenot1.35464461
53MP0003878_abnormal_ear_physiology1.35464461
54* MP0001286_abnormal_eye_development1.33827890
55MP0002111_abnormal_tail_morphology1.32711953
56* MP0000432_abnormal_head_morphology1.32328402
57MP0000778_abnormal_nervous_system1.32040055
58MP0002233_abnormal_nose_morphology1.30921705
59MP0003942_abnormal_urinary_system1.28816564
60MP0000537_abnormal_urethra_morphology1.27197952
61MP0003755_abnormal_palate_morphology1.24005261
62MP0003937_abnormal_limbs/digits/tail_de1.21739258
63MP0009703_decreased_birth_body1.21301280
64MP0003984_embryonic_growth_retardation1.19819785
65MP0003787_abnormal_imprinting1.17842058
66MP0002088_abnormal_embryonic_growth/wei1.17335287
67MP0003786_premature_aging1.15895205
68MP0003718_maternal_effect1.13660029
69MP0002086_abnormal_extraembryonic_tissu1.11911499
70MP0003567_abnormal_fetal_cardiomyocyte1.10390146
71MP0003880_abnormal_central_pattern1.10259322
72MP0003935_abnormal_craniofacial_develop1.08780952
73MP0005248_abnormal_Harderian_gland1.08702311
74* MP0002116_abnormal_craniofacial_bone1.08639474
75MP0001485_abnormal_pinna_reflex1.05330028
76MP0002080_prenatal_lethality1.03253321
77MP0003385_abnormal_body_wall0.99717205
78MP0002751_abnormal_autonomic_nervous0.97164052
79MP0000762_abnormal_tongue_morphology0.96714744
80MP0005623_abnormal_meninges_morphology0.96009484
81MP0010352_gastrointestinal_tract_polyps0.95600815
82* MP0002152_abnormal_brain_morphology0.94598654
83MP0002114_abnormal_axial_skeleton0.94285403
84MP0004885_abnormal_endolymph0.93801661
85* MP0002697_abnormal_eye_size0.93543749
86MP0003938_abnormal_ear_development0.93199214
87MP0002210_abnormal_sex_determination0.92645332
88MP0000428_abnormal_craniofacial_morphol0.91845407
89MP0002932_abnormal_joint_morphology0.89527594
90MP0002736_abnormal_nociception_after0.89002029
91MP0009250_abnormal_appendicular_skeleto0.88949597
92MP0002234_abnormal_pharynx_morphology0.88520542
93MP0005076_abnormal_cell_differentiation0.86288010
94MP0009697_abnormal_copulation0.86126436
95MP0009046_muscle_twitch0.85947228
96MP0009053_abnormal_anal_canal0.85827616
97MP0000955_abnormal_spinal_cord0.85535844
98MP0002160_abnormal_reproductive_system0.85454739
99MP0001177_atelectasis0.85357861
100MP0000631_abnormal_neuroendocrine_gland0.84396055
101MP0009672_abnormal_birth_weight0.83901169
102MP0002102_abnormal_ear_morphology0.82175483
103* MP0005391_vision/eye_phenotype0.81762050
104* MP0002092_abnormal_eye_morphology0.81271742
105MP0005389_reproductive_system_phenotype0.81174583
106MP0000313_abnormal_cell_death0.80650356
107* MP0002081_perinatal_lethality0.78287620
108MP0001486_abnormal_startle_reflex0.78259809
109MP0001145_abnormal_male_reproductive0.78214845
110MP0001919_abnormal_reproductive_system0.77486783
111MP0004142_abnormal_muscle_tone0.76825738
112MP0004233_abnormal_muscle_weight0.75707310
113MP0000678_abnormal_parathyroid_gland0.75698677
114MP0002822_catalepsy0.74190582
115MP0005253_abnormal_eye_physiology0.73511952
116* MP0002752_abnormal_somatic_nervous0.73386321
117MP0000026_abnormal_inner_ear0.72658545
118MP0005187_abnormal_penis_morphology0.71633726
119MP0002127_abnormal_cardiovascular_syste0.71290166
120MP0001299_abnormal_eye_distance/0.70530015
121MP0000653_abnormal_sex_gland0.70183948

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)3.73933243
2Rectal fistula (HP:0100590)3.60040245
3Rectovaginal fistula (HP:0000143)3.60040245
4Absent radius (HP:0003974)3.50947258
5Aplasia involving forearm bones (HP:0009822)3.45674335
6Absent forearm bone (HP:0003953)3.45674335
7Abnormality of abdominal situs (HP:0011620)3.38471555
8Abdominal situs inversus (HP:0003363)3.38471555
9Abnormality of the labia minora (HP:0012880)3.26773518
10Reticulocytopenia (HP:0001896)3.24136114
11Ependymoma (HP:0002888)3.21274555
12Supernumerary spleens (HP:0009799)3.20318135
13Intestinal fistula (HP:0100819)3.14800172
14Selective tooth agenesis (HP:0001592)3.14008666
15Intestinal atresia (HP:0011100)3.13082705
16Abnormal number of incisors (HP:0011064)3.12225945
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99058048
18Colon cancer (HP:0003003)2.93767557
19Medulloblastoma (HP:0002885)2.87574301
20Vaginal fistula (HP:0004320)2.85436445
21Absent septum pellucidum (HP:0001331)2.84444029
22Septo-optic dysplasia (HP:0100842)2.81999911
23Chromsome breakage (HP:0040012)2.75866348
24Aplasia/hypoplasia of the humerus (HP:0006507)2.68516468
25Stenosis of the external auditory canal (HP:0000402)2.53881220
26Birth length less than 3rd percentile (HP:0003561)2.53140087
27Supernumerary ribs (HP:0005815)2.52316112
28Supernumerary bones of the axial skeleton (HP:0009144)2.51670159
29Esophageal atresia (HP:0002032)2.51601560
30Short humerus (HP:0005792)2.51456990
31Astrocytoma (HP:0009592)2.50906935
32Abnormality of the astrocytes (HP:0100707)2.50906935
33Hepatoblastoma (HP:0002884)2.50512290
34Impulsivity (HP:0100710)2.47587127
35Bifid tongue (HP:0010297)2.45011207
36Partial duplication of thumb phalanx (HP:0009944)2.44098275
37Patellar aplasia (HP:0006443)2.44007712
38Nephroblastoma (Wilms tumor) (HP:0002667)2.43013010
39Anophthalmia (HP:0000528)2.41057809
40Oligodactyly (HP:0012165)2.39226664
41Oral leukoplakia (HP:0002745)2.36753981
42Aplasia/Hypoplasia of the patella (HP:0006498)2.35908628
43Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.34233891
44Horseshoe kidney (HP:0000085)2.33082905
45Anal stenosis (HP:0002025)2.32552104
46Gastrointestinal atresia (HP:0002589)2.30787415
47Aplasia/Hypoplasia of the sternum (HP:0006714)2.29952352
48Glioma (HP:0009733)2.29641204
49Ectopic kidney (HP:0000086)2.28742793
50Choanal stenosis (HP:0000452)2.28193575
51Breast hypoplasia (HP:0003187)2.26583153
52Hemivertebrae (HP:0002937)2.26307562
53Cutaneous finger syndactyly (HP:0010554)2.25642903
54Embryonal renal neoplasm (HP:0011794)2.25348211
55Oligodactyly (hands) (HP:0001180)2.24789343
56Shawl scrotum (HP:0000049)2.24195132
57Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.20990428
58Rhabdomyosarcoma (HP:0002859)2.20714112
59Duplication of thumb phalanx (HP:0009942)2.20594925
60Absent thumb (HP:0009777)2.19967376
61Carpal bone hypoplasia (HP:0001498)2.19266961
62Cutaneous syndactyly (HP:0012725)2.19107872
63Abnormal lung lobation (HP:0002101)2.18616979
64Partial duplication of the phalanx of hand (HP:0009999)2.15780298
65Aqueductal stenosis (HP:0002410)2.13900954
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.10673867
67Abnormality of cells of the erythroid lineage (HP:0012130)2.09546985
68Neoplasm of the oral cavity (HP:0100649)2.09410516
69Vertebral fusion (HP:0002948)2.09338728
70Asplenia (HP:0001746)2.09312706
71Macrocytic anemia (HP:0001972)2.08375224
72Neoplasm of striated muscle (HP:0009728)2.06847159
73Abnormality of the ileum (HP:0001549)2.06352786
74Pseudobulbar signs (HP:0002200)2.04654892
75Meckel diverticulum (HP:0002245)2.04446323
76Holoprosencephaly (HP:0001360)2.03866866
77Abnormality of cochlea (HP:0000375)2.02316306
78Facial cleft (HP:0002006)2.01819048
79High anterior hairline (HP:0009890)2.01738300
80Broad thumb (HP:0011304)2.01526887
81Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01033331
82Cortical dysplasia (HP:0002539)2.00539817
83Missing ribs (HP:0000921)1.96945385
84Optic nerve hypoplasia (HP:0000609)1.96914239
85Preaxial foot polydactyly (HP:0001841)1.96766399
86Coronal craniosynostosis (HP:0004440)1.95908302
87Aplasia/Hypoplasia of the spleen (HP:0010451)1.95882470
88Malignant gastrointestinal tract tumors (HP:0006749)1.95577649
89Gastrointestinal carcinoma (HP:0002672)1.95577649
90Abnormality of homocysteine metabolism (HP:0010919)1.94279466
91Homocystinuria (HP:0002156)1.94279466
92Abnormality of the anterior horn cell (HP:0006802)1.93241749
93Degeneration of anterior horn cells (HP:0002398)1.93241749
94Tracheoesophageal fistula (HP:0002575)1.91059012
95Increased nuchal translucency (HP:0010880)1.90491821
96Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.90249054
97Short 1st metacarpal (HP:0010034)1.90249054
98Abnormal number of erythroid precursors (HP:0012131)1.89227770
99Volvulus (HP:0002580)1.88192124
100Abnormality of the preputium (HP:0100587)1.87659238
101Short thumb (HP:0009778)1.87042285
102Preaxial hand polydactyly (HP:0001177)1.86955600
103Abnormality of the middle phalanges of the toes (HP:0010183)1.84804586
104Breast aplasia (HP:0100783)1.83766993
105Turricephaly (HP:0000262)1.82747725
106Bilateral microphthalmos (HP:0007633)1.82441182
107Midline defect of the nose (HP:0004122)1.82324724
108Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81913856
109Short 4th metacarpal (HP:0010044)1.81913856
110Pendular nystagmus (HP:0012043)1.81525263
111Trigonocephaly (HP:0000243)1.81263764
112Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.80903453
113Facial hemangioma (HP:0000329)1.80360027
114Anencephaly (HP:0002323)1.79680817
115Abnormality of the incisor (HP:0000676)1.78977570
116Anal atresia (HP:0002023)1.78733024
117Premature graying of hair (HP:0002216)1.78580291
118Short phalanx of the thumb (HP:0009660)1.77808734
119Abnormality of the lacrimal duct (HP:0011481)1.77419871
120Squamous cell carcinoma (HP:0002860)1.77208666
121Atresia of the external auditory canal (HP:0000413)1.74735837
122Absent eyebrow (HP:0002223)1.74686828
123Triphalangeal thumb (HP:0001199)1.74423570
124Abnormality of the septum pellucidum (HP:0007375)1.72877574
125Hemiparesis (HP:0001269)1.72693070
126Broad phalanges of the hand (HP:0009768)1.71424616
127Abnormality of chromosome stability (HP:0003220)1.70075970
128Broad finger (HP:0001500)1.68315644
129Maternal diabetes (HP:0009800)1.68138558
130Abnormality of the diencephalon (HP:0010662)1.67492469
131Aplasia/Hypoplasia of the breasts (HP:0010311)1.67384247
132Pancreatic fibrosis (HP:0100732)1.67297060
133Agnosia (HP:0010524)1.66237826
134Abnormality of the duodenum (HP:0002246)1.66077845
135Optic nerve coloboma (HP:0000588)1.66054014
136Myelomeningocele (HP:0002475)1.65898990
137Abnormality of the lower motor neuron (HP:0002366)1.65450115
138Leiomyosarcoma (HP:0100243)1.64894694
139Broad distal phalanx of finger (HP:0009836)1.64609073
140Omphalocele (HP:0001539)1.62883308
141Renal hypoplasia (HP:0000089)1.62871811
142Chronic bronchitis (HP:0004469)1.61333488
143Hypoplastic female external genitalia (HP:0012815)1.61239689
144Sclerocornea (HP:0000647)1.61013649
145Abnormality of the carotid arteries (HP:0005344)1.59224745
146Abnormal hair whorl (HP:0010721)1.59122713
147Small intestinal stenosis (HP:0012848)1.58091261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.45655801
2CDC73.80087509
3MKNK23.50202197
4MKNK13.29620266
5SRPK13.25232021
6CDK123.02978757
7TTK2.79240366
8BUB12.55023639
9WEE12.53516723
10VRK22.28375417
11TAF12.11206700
12LATS22.05042844
13NEK22.00953151
14PLK11.95698515
15MAP3K101.92524335
16PLK31.87911208
17AKT31.83205221
18WNK31.82350224
19ALK1.68673904
20CDK71.66301139
21TSSK61.63720690
22FGFR21.59874763
23PBK1.55155430
24CHEK21.55073436
25ATR1.54642793
26BRD41.50103095
27EPHA21.48610395
28YES11.48527966
29PLK41.46999559
30STK38L1.41619001
31ICK1.36720898
32NUAK11.35660202
33CHEK11.34126798
34CASK1.33929936
35AURKB1.33657134
36TRIM281.28000687
37EIF2AK11.27367053
38AURKA1.24142632
39MAP3K91.22461874
40EIF2AK21.19284616
41CAMK1D1.18147327
42NEK11.17710591
43CDK21.10741501
44ATM1.10560695
45IRAK21.08862092
46NME11.02704549
47VRK11.01650169
48CDK61.00108096
49BMPR1B0.99559569
50PRPF4B0.96474416
51CDK190.95810248
52LATS10.95462569
53STK30.94667450
54CSNK1E0.94200286
55NLK0.93370476
56FGFR10.91548572
57CDK10.90951940
58EPHA40.89215628
59TLK10.87064546
60PAK40.86319673
61DYRK30.84946893
62EPHB20.83527299
63ERBB30.82802347
64NEK60.82530579
65TYRO30.80836916
66CSNK1G10.79756266
67ZAK0.76759329
68RPS6KB20.75777738
69NTRK30.75697596
70PASK0.74896085
71PRKDC0.71921303
72MAP3K80.71856526
73CSNK2A20.71471171
74UHMK10.69502460
75STK240.69220326
76CSNK2A10.69184570
77CDK30.65474904
78STK100.65263832
79MARK10.64645607
80BRAF0.63387462
81DYRK20.62878277
82PLK20.62125439
83CSNK1G20.61751213
84RPS6KA40.60788008
85MELK0.60378397
86MAPK140.60209047
87GRK10.59775531
88SMG10.59702181
89CDK40.59602035
90BCR0.56318124
91GSK3B0.56153694
92CAMK1G0.56031405
93BRSK20.55940428
94MAP3K40.54428166
95AKT20.52092519
96NTRK20.51813386
97DDR20.51484561
98MINK10.50693102
99SGK20.50465688
100TESK20.49422766
101PRKCI0.47965912
102CSNK1D0.47163316
103CSNK1G30.46848805
104TNIK0.46701434
105STK40.45315070
106BRSK10.45065143
107MTOR0.44017387
108MAPK100.41754414
109MST40.41611052
110PRKCG0.41002449
111PIM10.40018433
112MAPK10.39251662
113AKT10.38965230
114ERBB40.38852321
115DYRK1A0.37378907
116ACVR1B0.36605627
117FGR0.36600751
118OXSR10.36364821
119CSNK1A1L0.36088062
120MAPK90.35986090
121CDK150.35917190
122CDK80.35915947
123CAMK40.35612593
124EEF2K0.35518639
125STK160.35437523
126IRAK10.35248389
127CDK140.35233015
128KSR10.34824972
129STK380.34737663
130INSRR0.34520619
131CDK180.34494502
132CDK11A0.33756421
133ADRBK20.33558283
134SGK2230.32044842
135SGK4940.32044842

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.23293810
2DNA replication_Homo sapiens_hsa030303.82208446
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.79452522
4Spliceosome_Homo sapiens_hsa030403.48372975
5RNA transport_Homo sapiens_hsa030133.05647882
6Homologous recombination_Homo sapiens_hsa034403.04447174
7One carbon pool by folate_Homo sapiens_hsa006702.91705097
8RNA polymerase_Homo sapiens_hsa030202.87143284
9Fanconi anemia pathway_Homo sapiens_hsa034602.84541583
10mRNA surveillance pathway_Homo sapiens_hsa030152.58166870
11Base excision repair_Homo sapiens_hsa034102.45650819
12Nucleotide excision repair_Homo sapiens_hsa034202.41459926
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34115679
14Cell cycle_Homo sapiens_hsa041102.27050464
15Basal cell carcinoma_Homo sapiens_hsa052172.24392824
16Fatty acid biosynthesis_Homo sapiens_hsa000612.21043211
17RNA degradation_Homo sapiens_hsa030181.84878009
18Hedgehog signaling pathway_Homo sapiens_hsa043401.83501686
19Hippo signaling pathway_Homo sapiens_hsa043901.76188906
20Basal transcription factors_Homo sapiens_hsa030221.70908961
21Pyrimidine metabolism_Homo sapiens_hsa002401.69191492
22Ribosome_Homo sapiens_hsa030101.69133143
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.64472330
24Parkinsons disease_Homo sapiens_hsa050121.61934410
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61590996
26Oxidative phosphorylation_Homo sapiens_hsa001901.59090281
27Proteasome_Homo sapiens_hsa030501.56238207
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52250484
29Oocyte meiosis_Homo sapiens_hsa041141.39059818
30Non-homologous end-joining_Homo sapiens_hsa034501.35628859
31Nicotine addiction_Homo sapiens_hsa050331.33063751
32p53 signaling pathway_Homo sapiens_hsa041151.27865566
33Wnt signaling pathway_Homo sapiens_hsa043101.27543983
34Steroid biosynthesis_Homo sapiens_hsa001001.22895477
35Protein export_Homo sapiens_hsa030601.21776229
36Pyruvate metabolism_Homo sapiens_hsa006201.20489364
37Adherens junction_Homo sapiens_hsa045201.17887566
38TGF-beta signaling pathway_Homo sapiens_hsa043501.15523389
39MicroRNAs in cancer_Homo sapiens_hsa052061.14854392
40Notch signaling pathway_Homo sapiens_hsa043301.12644702
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06630771
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01602965
43Thyroid cancer_Homo sapiens_hsa052161.00511859
44Colorectal cancer_Homo sapiens_hsa052101.00357852
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.00175729
46Propanoate metabolism_Homo sapiens_hsa006400.95150832
47Alzheimers disease_Homo sapiens_hsa050100.94956225
48Purine metabolism_Homo sapiens_hsa002300.93805110
49Melanoma_Homo sapiens_hsa052180.90151564
50Cardiac muscle contraction_Homo sapiens_hsa042600.88930777
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88841686
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88432406
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82654318
54Nitrogen metabolism_Homo sapiens_hsa009100.81406528
55Tight junction_Homo sapiens_hsa045300.81115939
56Melanogenesis_Homo sapiens_hsa049160.79849370
57Glutamatergic synapse_Homo sapiens_hsa047240.73531296
58Vitamin digestion and absorption_Homo sapiens_hsa049770.72138477
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69390463
60Folate biosynthesis_Homo sapiens_hsa007900.68886221
61Pathways in cancer_Homo sapiens_hsa052000.68336146
62Biosynthesis of amino acids_Homo sapiens_hsa012300.67298409
63Lysine degradation_Homo sapiens_hsa003100.66520488
64Long-term depression_Homo sapiens_hsa047300.63268836
65Long-term potentiation_Homo sapiens_hsa047200.62387665
66Epstein-Barr virus infection_Homo sapiens_hsa051690.62119830
67HTLV-I infection_Homo sapiens_hsa051660.60912858
68Phototransduction_Homo sapiens_hsa047440.59971868
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.59594208
70Systemic lupus erythematosus_Homo sapiens_hsa053220.59187554
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56707303
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55796673
73Axon guidance_Homo sapiens_hsa043600.55610488
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52922801
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52862003
76Carbon metabolism_Homo sapiens_hsa012000.52139603
77Endometrial cancer_Homo sapiens_hsa052130.51960936
78Alcoholism_Homo sapiens_hsa050340.50494979
79Taste transduction_Homo sapiens_hsa047420.49588576
80GABAergic synapse_Homo sapiens_hsa047270.46681424
81Selenocompound metabolism_Homo sapiens_hsa004500.46402070
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45172643
83Fructose and mannose metabolism_Homo sapiens_hsa000510.45103336
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44933754
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43972530
86Prostate cancer_Homo sapiens_hsa052150.43716763
87Viral carcinogenesis_Homo sapiens_hsa052030.43274550
88mTOR signaling pathway_Homo sapiens_hsa041500.43074180
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43014669
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42453600
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41779216
92Metabolic pathways_Homo sapiens_hsa011000.39973564
93Bladder cancer_Homo sapiens_hsa052190.39934364
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39074143
95Gap junction_Homo sapiens_hsa045400.38692968
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34328139
97Fatty acid elongation_Homo sapiens_hsa000620.34162647
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34002934
99Rap1 signaling pathway_Homo sapiens_hsa040150.32376985
100Small cell lung cancer_Homo sapiens_hsa052220.29557300
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29185399
102Sulfur relay system_Homo sapiens_hsa041220.28590007
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28528745
104HIF-1 signaling pathway_Homo sapiens_hsa040660.28343226
105Proteoglycans in cancer_Homo sapiens_hsa052050.27184263
106Vitamin B6 metabolism_Homo sapiens_hsa007500.26968882
107Huntingtons disease_Homo sapiens_hsa050160.26432282
108Morphine addiction_Homo sapiens_hsa050320.25002917
109Dopaminergic synapse_Homo sapiens_hsa047280.24292437
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23493529
111Glutathione metabolism_Homo sapiens_hsa004800.23343476
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23216465
113Arginine and proline metabolism_Homo sapiens_hsa003300.22208785
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21956261
115Herpes simplex infection_Homo sapiens_hsa051680.21757202
116Amphetamine addiction_Homo sapiens_hsa050310.21409888
117Circadian entrainment_Homo sapiens_hsa047130.20128229
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19419445
119Calcium signaling pathway_Homo sapiens_hsa040200.19323495
120ErbB signaling pathway_Homo sapiens_hsa040120.18525377
121beta-Alanine metabolism_Homo sapiens_hsa004100.18322742
122Estrogen signaling pathway_Homo sapiens_hsa049150.18229069
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18083336
124Serotonergic synapse_Homo sapiens_hsa047260.17042824
125Olfactory transduction_Homo sapiens_hsa047400.16874296
126Cocaine addiction_Homo sapiens_hsa050300.15646262
127Choline metabolism in cancer_Homo sapiens_hsa052310.13682012
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.13586037
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13465523
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13394326
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13093952
132MAPK signaling pathway_Homo sapiens_hsa040100.12932856
133Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11688786

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