ZIK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heparin biosynthetic process (GO:0030210)6.31518743
2heparin metabolic process (GO:0030202)6.31518743
3negative regulation of telomerase activity (GO:0051974)5.43711408
4spliceosomal tri-snRNP complex assembly (GO:0000244)5.25585634
5mRNA splice site selection (GO:0006376)4.65169509
6pyrimidine nucleobase catabolic process (GO:0006208)4.51640619
7replication fork processing (GO:0031297)4.41607634
8somatic hypermutation of immunoglobulin genes (GO:0016446)4.35535168
9somatic diversification of immune receptors via somatic mutation (GO:0002566)4.35535168
10mitochondrial genome maintenance (GO:0000002)4.32161693
11chromatin remodeling at centromere (GO:0031055)4.17792076
12meiotic chromosome segregation (GO:0045132)4.00541621
13mitochondrion transport along microtubule (GO:0047497)3.95083216
14establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.95083216
15CENP-A containing nucleosome assembly (GO:0034080)3.94080742
16atrial cardiac muscle cell action potential (GO:0086014)3.88342012
17establishment of mitochondrion localization (GO:0051654)3.83522536
18DNA double-strand break processing (GO:0000729)3.82334269
19mitochondrial DNA replication (GO:0006264)3.81471281
20central nervous system projection neuron axonogenesis (GO:0021952)3.78543028
21viral mRNA export from host cell nucleus (GO:0046784)3.77188604
22response to pheromone (GO:0019236)3.70586721
23kidney morphogenesis (GO:0060993)3.59916138
24neuron recognition (GO:0008038)3.59657646
25regulation of mitotic spindle checkpoint (GO:1903504)3.56176418
26regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.56176418
27histone exchange (GO:0043486)3.55534083
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.53766466
29resolution of meiotic recombination intermediates (GO:0000712)3.53751167
30regulation of telomerase activity (GO:0051972)3.52106914
31maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.50683299
32kinetochore assembly (GO:0051382)3.47646492
33negative regulation of DNA recombination (GO:0045910)3.47132173
34negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.46148694
35DNA replication-dependent nucleosome organization (GO:0034723)3.41490816
36DNA replication-dependent nucleosome assembly (GO:0006335)3.41490816
37regulation of helicase activity (GO:0051095)3.41402672
38kinetochore organization (GO:0051383)3.41218525
39cell migration in hindbrain (GO:0021535)3.33471719
40histone H2A acetylation (GO:0043968)3.31496229
41DNA-dependent DNA replication (GO:0006261)3.30388725
42nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.28766945
43negative regulation of DNA-dependent DNA replication (GO:2000104)3.27886001
44regulation of nuclear cell cycle DNA replication (GO:0033262)3.22154680
45axonal fasciculation (GO:0007413)3.20699364
46presynaptic membrane assembly (GO:0097105)3.16975014
47histone-serine phosphorylation (GO:0035404)3.16558660
48DNA replication-independent nucleosome organization (GO:0034724)3.15537032
49DNA replication-independent nucleosome assembly (GO:0006336)3.15537032
50nucleobase catabolic process (GO:0046113)3.12873585
51spliceosomal complex assembly (GO:0000245)3.11936612
52negative regulation of mRNA processing (GO:0050686)3.09904817
53regulation of gene silencing by miRNA (GO:0060964)3.08977923
54regulation of gene silencing by RNA (GO:0060966)3.08977923
55regulation of posttranscriptional gene silencing (GO:0060147)3.08977923
56neuron cell-cell adhesion (GO:0007158)3.06421251
57negative regulation of microtubule polymerization (GO:0031115)3.04552550
58negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04434640
59negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04434640
60negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04434640
61negative regulation of mitotic sister chromatid separation (GO:2000816)3.04434640
62negative regulation of sister chromatid segregation (GO:0033046)3.04434640
63deoxyribonucleotide biosynthetic process (GO:0009263)3.03952003
64spindle checkpoint (GO:0031577)3.03491292
65protein K6-linked ubiquitination (GO:0085020)3.03137259
66layer formation in cerebral cortex (GO:0021819)3.02491470
67spliceosomal snRNP assembly (GO:0000387)3.02080141
68negative regulation of chromosome segregation (GO:0051985)3.00687078
69metaphase plate congression (GO:0051310)3.00224477
70regulation of short-term neuronal synaptic plasticity (GO:0048172)2.98752773
71DNA ligation (GO:0006266)2.98384654
72negative regulation of RNA splicing (GO:0033119)2.97967916
73exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96704095
74regulation of mRNA splicing, via spliceosome (GO:0048024)2.96407941
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.95427868
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95203564
77tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95203564
78negative regulation of translation, ncRNA-mediated (GO:0040033)2.93876029
79regulation of translation, ncRNA-mediated (GO:0045974)2.93876029
80negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.93876029
81DNA unwinding involved in DNA replication (GO:0006268)2.93706130
82chondroitin sulfate biosynthetic process (GO:0030206)2.93347811
83protein localization to synapse (GO:0035418)2.93130869
84mitotic spindle checkpoint (GO:0071174)2.92107782
85negative regulation of oligodendrocyte differentiation (GO:0048715)2.91309467
86regulation of chemokine-mediated signaling pathway (GO:0070099)2.91130038
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.90521155
88centriole replication (GO:0007099)2.90095993
89protein localization to kinetochore (GO:0034501)2.89697244
90pyrimidine dimer repair (GO:0006290)2.87700458
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.87317116
92establishment of integrated proviral latency (GO:0075713)2.86705306
93postsynaptic membrane organization (GO:0001941)2.86131408
94non-recombinational repair (GO:0000726)2.85970931
95double-strand break repair via nonhomologous end joining (GO:0006303)2.85970931
96vocalization behavior (GO:0071625)2.85615412
97dendrite development (GO:0016358)2.85239753
98dendritic spine morphogenesis (GO:0060997)2.83807411
99forebrain neuron differentiation (GO:0021879)2.83551209
100cerebral cortex radially oriented cell migration (GO:0021799)2.82973097
101DNA damage response, detection of DNA damage (GO:0042769)2.82791309
102telomere maintenance via telomerase (GO:0007004)2.82585871
103cranial nerve structural organization (GO:0021604)2.81852125
104regulation of glutamate receptor signaling pathway (GO:1900449)2.79816308
105regulation of meiosis I (GO:0060631)2.78632152
106mismatch repair (GO:0006298)2.78418037
107histone arginine methylation (GO:0034969)2.78267837
108motile cilium assembly (GO:0044458)2.76737154
109paraxial mesoderm development (GO:0048339)2.76139439
110establishment of nucleus localization (GO:0040023)2.75684895
111auditory behavior (GO:0031223)2.75455850
112regulation of centriole replication (GO:0046599)2.75429904
1132-deoxyribonucleotide biosynthetic process (GO:0009265)2.75268712
114deoxyribose phosphate biosynthetic process (GO:0046385)2.75268712
115recombinational repair (GO:0000725)2.75060278
116hippocampus development (GO:0021766)2.74615633
117female gonad development (GO:0008585)2.73969631
118synaptic vesicle docking involved in exocytosis (GO:0016081)2.73694369
119peptidyl-lysine trimethylation (GO:0018023)2.73635881
120mitotic spindle assembly checkpoint (GO:0007094)2.73568691
121ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.73510071
122cell proliferation in forebrain (GO:0021846)2.73312738
123central nervous system neuron axonogenesis (GO:0021955)2.72792423
124negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72014560
125synaptic vesicle exocytosis (GO:0016079)2.71421527
126regulation of mitotic metaphase/anaphase transition (GO:0030071)2.70957406
127regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.70957406
128double-strand break repair via homologous recombination (GO:0000724)2.70666852
129negative chemotaxis (GO:0050919)2.70569684
130regulation of mitotic sister chromatid segregation (GO:0033047)2.69959823
131regulation of sister chromatid segregation (GO:0033045)2.69959823
132regulation of mitotic sister chromatid separation (GO:0010965)2.69959823
133reciprocal DNA recombination (GO:0035825)2.68804451
134reciprocal meiotic recombination (GO:0007131)2.68804451
135spindle assembly checkpoint (GO:0071173)2.68754525
136mitotic metaphase plate congression (GO:0007080)2.68615280
137mitochondrial DNA metabolic process (GO:0032042)2.68536771
138dosage compensation (GO:0007549)2.67543239
139regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.67327600
140negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.66993642
141neuron remodeling (GO:0016322)2.66622171
142urogenital system development (GO:0001655)2.65983466
143regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.65954001
144behavioral response to nicotine (GO:0035095)2.65553686
145ATP-dependent chromatin remodeling (GO:0043044)2.64919040
146regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.64621428
147microtubule depolymerization (GO:0007019)2.64598055
148positive regulation of synapse maturation (GO:0090129)2.64060057
149somite development (GO:0061053)2.63475094
150nucleosome disassembly (GO:0006337)2.63256979
151protein-DNA complex disassembly (GO:0032986)2.63256979
152presynaptic membrane organization (GO:0097090)2.62990943
153peptidyl-arginine omega-N-methylation (GO:0035247)2.62871686
154DNA replication checkpoint (GO:0000076)2.61380719
155regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.60630970
156synapsis (GO:0007129)2.59744401
157ionotropic glutamate receptor signaling pathway (GO:0035235)2.59556507
158sister chromatid segregation (GO:0000819)2.59371680
159telomere maintenance via telomere lengthening (GO:0010833)2.58917855
160peptidyl-arginine methylation (GO:0018216)2.58339286
161peptidyl-arginine N-methylation (GO:0035246)2.58339286
162mitotic nuclear envelope reassembly (GO:0007084)2.56988271
163nuclear envelope reassembly (GO:0031468)2.56988271
164deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.56550048
165glutamate receptor signaling pathway (GO:0007215)2.56415666
166limb bud formation (GO:0060174)2.56275772
167proteoglycan biosynthetic process (GO:0030166)2.56136998
168translesion synthesis (GO:0019985)2.55478024
169olfactory bulb development (GO:0021772)2.55353048
170positive regulation of histone H3-K4 methylation (GO:0051571)2.55269807
171negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.55187573
172postreplication repair (GO:0006301)2.53898489
173regulation of development, heterochronic (GO:0040034)2.52054204
174regulation of chromosome segregation (GO:0051983)2.51625808
175mitotic sister chromatid segregation (GO:0000070)2.51555285
176L-serine metabolic process (GO:0006563)2.49085632
177peptidyl-histidine modification (GO:0018202)2.48997390
178attachment of spindle microtubules to kinetochore (GO:0008608)2.47653176
179DNA strand renaturation (GO:0000733)2.47297450
180negative regulation of mitosis (GO:0045839)2.46613478
181histone mRNA metabolic process (GO:0008334)2.46481480
182DNA recombination (GO:0006310)2.43776555
183neural tube formation (GO:0001841)2.43313923
184cullin deneddylation (GO:0010388)2.43184700
185intraciliary transport (GO:0042073)2.42035203
186regulation of timing of cell differentiation (GO:0048505)2.40799538
187DNA strand elongation involved in DNA replication (GO:0006271)2.40437254
188RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.39344794
189establishment of chromosome localization (GO:0051303)2.38798135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.18033092
2E2F7_22180533_ChIP-Seq_HELA_Human4.39421116
3GBX2_23144817_ChIP-Seq_PC3_Human4.34439562
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.75316090
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.61276817
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.43006298
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.37085884
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27274431
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.63309215
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.61274217
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.60750201
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.42192332
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.37244456
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36254358
15SOX2_18555785_ChIP-Seq_MESCs_Mouse2.34454966
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.27506119
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.16574722
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15840124
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.07075497
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04883642
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.98281788
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96048527
23ELK1_19687146_ChIP-ChIP_HELA_Human1.94656449
24VDR_22108803_ChIP-Seq_LS180_Human1.91809081
25FOXM1_23109430_ChIP-Seq_U2OS_Human1.90247801
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90044468
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.84802213
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.83619383
29IRF1_19129219_ChIP-ChIP_H3396_Human1.81285834
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78561127
31FUS_26573619_Chip-Seq_HEK293_Human1.78559960
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78210057
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75207203
34RNF2_27304074_Chip-Seq_NSC_Mouse1.74501157
35REST_21632747_ChIP-Seq_MESCs_Mouse1.74485753
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.73657472
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68405677
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68405677
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68069007
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67628826
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66839528
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66410238
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64834501
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.63858174
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63852347
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.63176999
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61600063
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60700860
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60164912
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.56864893
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.56850556
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.56836496
53NANOG_16153702_ChIP-ChIP_HESCs_Human1.54979674
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.50618244
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50101493
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48176040
57VDR_23849224_ChIP-Seq_CD4+_Human1.47237763
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47210532
59* REST_18959480_ChIP-ChIP_MESCs_Mouse1.46142100
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43788436
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42777587
62P300_19829295_ChIP-Seq_ESCs_Human1.42159723
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42130999
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42096430
65ZNF274_21170338_ChIP-Seq_K562_Hela1.40690366
66FOXP3_21729870_ChIP-Seq_TREG_Human1.37711946
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37567106
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34717261
69TAF15_26573619_Chip-Seq_HEK293_Human1.34432958
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34347951
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32357127
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31119684
73SOX9_26525672_Chip-Seq_HEART_Mouse1.30956483
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30729694
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30375476
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30014908
77OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.28588993
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27613720
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27523910
80EWS_26573619_Chip-Seq_HEK293_Human1.27150738
81SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.25560145
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25519904
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23682306
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21562086
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.19898176
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19862133
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17942081
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.16805652
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.16321449
90PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15646865
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15282327
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15282327
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13721956
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12904290
95MYC_18555785_ChIP-Seq_MESCs_Mouse1.12639568
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11746358
97POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.11180396
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11010799
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10591730
100TTF2_22483619_ChIP-Seq_HELA_Human1.10133706
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.09662959
102MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08997972
103MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08944846
104ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08703304
105TP53_22573176_ChIP-Seq_HFKS_Human1.08534472
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08448628
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06936535
108SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06517041
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.06335145
110FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06044730
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04770828
112GATA1_26923725_Chip-Seq_HPCs_Mouse1.04425833
113MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04217297
114SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03900254
115BCAT_22108803_ChIP-Seq_LS180_Human1.03879269
116KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03533852
117KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03533852
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03533852
119RARB_27405468_Chip-Seq_BRAIN_Mouse1.03529369
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02439084
121IGF1R_20145208_ChIP-Seq_DFB_Human1.02350239
122JUN_21703547_ChIP-Seq_K562_Human1.01197540
123SOX2_21211035_ChIP-Seq_LN229_Gbm1.00274931
124HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99403587
125SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97680302
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97053097
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96969261
128CBP_20019798_ChIP-Seq_JUKART_Human0.96969261
129TP53_20018659_ChIP-ChIP_R1E_Mouse0.96863333
130ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96803844
131HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95084303
132WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93331988
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93279230
134SOX2_19829295_ChIP-Seq_ESCs_Human0.93071618
135NANOG_19829295_ChIP-Seq_ESCs_Human0.93071618
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92776596
137SALL1_21062744_ChIP-ChIP_HESCs_Human0.92558897
138STAT3_23295773_ChIP-Seq_U87_Human0.92487545
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92431320
140AR_21572438_ChIP-Seq_LNCaP_Human0.92281087
141KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92274862
142NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91016983
143SMAD4_21799915_ChIP-Seq_A2780_Human0.90442060
144MYC_18940864_ChIP-ChIP_HL60_Human0.89971971
145SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89839637
146MYCN_18555785_ChIP-Seq_MESCs_Mouse0.89651403
147NELFA_20434984_ChIP-Seq_ESCs_Mouse0.89412431
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88700924
149EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88278733
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87749442
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87244378
152FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86095353

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.22221064
2MP0000778_abnormal_nervous_system3.15131623
3MP0004270_analgesia3.07164134
4MP0010030_abnormal_orbit_morphology2.92871823
5MP0003693_abnormal_embryo_hatching2.85220054
6MP0008057_abnormal_DNA_replication2.83861623
7MP0000566_synostosis2.72900710
8MP0003880_abnormal_central_pattern2.71836175
9MP0005409_darkened_coat_color2.66652802
10MP0001986_abnormal_taste_sensitivity2.66329073
11MP0003122_maternal_imprinting2.52875971
12MP0005423_abnormal_somatic_nervous2.46566299
13MP0003121_genomic_imprinting2.41748193
14MP0004147_increased_porphyrin_level2.31439995
15MP0003787_abnormal_imprinting2.24543750
16MP0000049_abnormal_middle_ear2.08140694
17MP0003718_maternal_effect2.06478261
18MP0008789_abnormal_olfactory_epithelium2.04243300
19MP0003136_yellow_coat_color2.04210816
20MP0002734_abnormal_mechanical_nocicepti1.97603240
21MP0001293_anophthalmia1.96018923
22MP0001529_abnormal_vocalization1.95302082
23MP0003635_abnormal_synaptic_transmissio1.94513688
24MP0006292_abnormal_olfactory_placode1.90333288
25MP0004133_heterotaxia1.88849284
26MP0005394_taste/olfaction_phenotype1.86074690
27MP0005499_abnormal_olfactory_system1.86074690
28MP0002063_abnormal_learning/memory/cond1.85464140
29MP0002102_abnormal_ear_morphology1.77352187
30MP0001968_abnormal_touch/_nociception1.76224906
31MP0003077_abnormal_cell_cycle1.74895004
32MP0004957_abnormal_blastocyst_morpholog1.73905149
33MP0008932_abnormal_embryonic_tissue1.71025393
34MP0008877_abnormal_DNA_methylation1.66642081
35MP0002736_abnormal_nociception_after1.63618674
36MP0002557_abnormal_social/conspecific_i1.60977720
37MP0002184_abnormal_innervation1.60743738
38MP0006072_abnormal_retinal_apoptosis1.60321605
39MP0000015_abnormal_ear_pigmentation1.60108506
40MP0008007_abnormal_cellular_replicative1.58696324
41MP0002249_abnormal_larynx_morphology1.55831189
42MP0001188_hyperpigmentation1.54761519
43MP0000955_abnormal_spinal_cord1.49971819
44MP0003861_abnormal_nervous_system1.49023355
45MP0000631_abnormal_neuroendocrine_gland1.48043357
46MP0008058_abnormal_DNA_repair1.47780957
47MP0002572_abnormal_emotion/affect_behav1.46473031
48MP0010094_abnormal_chromosome_stability1.43342861
49MP0009745_abnormal_behavioral_response1.42852260
50MP0005248_abnormal_Harderian_gland1.38515284
51MP0005670_abnormal_white_adipose1.38247290
52MP0000537_abnormal_urethra_morphology1.36283093
53MP0006276_abnormal_autonomic_nervous1.33994036
54MP0004811_abnormal_neuron_physiology1.33610707
55MP0003938_abnormal_ear_development1.32766484
56MP0001286_abnormal_eye_development1.30888714
57MP0002751_abnormal_autonomic_nervous1.30817738
58MP0001486_abnormal_startle_reflex1.29550508
59MP0002254_reproductive_system_inflammat1.28624086
60MP0002152_abnormal_brain_morphology1.27985816
61MP0003315_abnormal_perineum_morphology1.27893025
62MP0003890_abnormal_embryonic-extraembry1.27873705
63MP0003567_abnormal_fetal_cardiomyocyte1.26631631
64MP0005645_abnormal_hypothalamus_physiol1.25066244
65MP0003123_paternal_imprinting1.24284359
66MP0005253_abnormal_eye_physiology1.24130879
67MP0005386_behavior/neurological_phenoty1.23135450
68MP0004924_abnormal_behavior1.23135450
69MP0001929_abnormal_gametogenesis1.21659901
70MP0002064_seizures1.21432641
71MP0002882_abnormal_neuron_morphology1.20844472
72MP0002697_abnormal_eye_size1.20514484
73MP0001502_abnormal_circadian_rhythm1.18918830
74MP0002938_white_spotting1.18283759
75MP0002089_abnormal_postnatal_growth/wei1.18106681
76MP0008995_early_reproductive_senescence1.17508892
77MP0003937_abnormal_limbs/digits/tail_de1.16371017
78MP0002653_abnormal_ependyma_morphology1.15722824
79MP0002210_abnormal_sex_determination1.15492738
80MP0002735_abnormal_chemical_nociception1.14938596
81MP0002116_abnormal_craniofacial_bone1.11522371
82MP0005551_abnormal_eye_electrophysiolog1.09651129
83MP0003755_abnormal_palate_morphology1.09542017
84MP0002084_abnormal_developmental_patter1.08839309
85MP0000026_abnormal_inner_ear1.06850106
86MP0003385_abnormal_body_wall1.05879351
87MP0009697_abnormal_copulation1.05421456
88MP0002114_abnormal_axial_skeleton1.04467556
89MP0002085_abnormal_embryonic_tissue1.03859050
90MP0002067_abnormal_sensory_capabilities1.02912871
91MP0003119_abnormal_digestive_system1.02797782
92MP0002081_perinatal_lethality1.02450532
93MP0002272_abnormal_nervous_system1.02196190
94MP0009703_decreased_birth_body1.01634885
95MP0009046_muscle_twitch1.00887783
96MP0003941_abnormal_skin_development1.00856944
97MP0004142_abnormal_muscle_tone1.00139581
98MP0000653_abnormal_sex_gland1.00109264
99MP0003115_abnormal_respiratory_system1.00050415
100MP0003942_abnormal_urinary_system0.99949844
101MP0003283_abnormal_digestive_organ0.99804229
102MP0001145_abnormal_male_reproductive0.99021211
103MP0002111_abnormal_tail_morphology0.98424755
104MP0003698_abnormal_male_reproductive0.98392979
105MP0002234_abnormal_pharynx_morphology0.96658039
106MP0004858_abnormal_nervous_system0.96423407
107MP0002233_abnormal_nose_morphology0.95994869
108MP0002752_abnormal_somatic_nervous0.95801668
109MP0006035_abnormal_mitochondrial_morpho0.95047332
110MP0003935_abnormal_craniofacial_develop0.94883225
111MP0005084_abnormal_gallbladder_morpholo0.94716855
112MP0002638_abnormal_pupillary_reflex0.94622484
113MP0000372_irregular_coat_pigmentation0.94228805
114MP0005391_vision/eye_phenotype0.93721815
115MP0005171_absent_coat_pigmentation0.93257512
116MP0003137_abnormal_impulse_conducting0.92835451
117MP0001485_abnormal_pinna_reflex0.92590291
118MP0002177_abnormal_outer_ear0.90480064
119MP0004885_abnormal_endolymph0.89024436
120MP0005646_abnormal_pituitary_gland0.88972082
121MP0004197_abnormal_fetal_growth/weight/0.87989871
122MP0001299_abnormal_eye_distance/0.87948833
123MP0009250_abnormal_appendicular_skeleto0.87279757
124MP0004742_abnormal_vestibular_system0.87149914
125MP0002733_abnormal_thermal_nociception0.86374535
126MP0005367_renal/urinary_system_phenotyp0.86128758
127MP0000516_abnormal_urinary_system0.86128758
128MP0004215_abnormal_myocardial_fiber0.84511233
129MP0009672_abnormal_birth_weight0.84345438
130MP0001346_abnormal_lacrimal_gland0.83577862
131MP0001119_abnormal_female_reproductive0.82884649
132MP0002066_abnormal_motor_capabilities/c0.82115378
133MP0001440_abnormal_grooming_behavior0.82034724
134MP0003195_calcinosis0.81550211
135MP0003111_abnormal_nucleus_morphology0.81368395
136MP0001984_abnormal_olfaction0.80866995
137MP0001324_abnormal_eye_pigmentation0.80408024
138MP0002282_abnormal_trachea_morphology0.80252385
139MP0001963_abnormal_hearing_physiology0.79446939
140MP0005195_abnormal_posterior_eye0.78571038
141MP0001730_embryonic_growth_arrest0.78379343
142MP0001697_abnormal_embryo_size0.78087731
143MP0001672_abnormal_embryogenesis/_devel0.77784942
144MP0005380_embryogenesis_phenotype0.77784942
145MP0002075_abnormal_coat/hair_pigmentati0.77446479
146MP0000428_abnormal_craniofacial_morphol0.77274357

Predicted human phenotypes

RankGene SetZ-score
1Overlapping toe (HP:0001845)5.52409528
2Rib fusion (HP:0000902)5.09216305
3Colon cancer (HP:0003003)4.44253142
4Large for gestational age (HP:0001520)4.40076186
5Shawl scrotum (HP:0000049)4.02155334
6Abnormality of macular pigmentation (HP:0008002)3.91711143
7Growth hormone deficiency (HP:0000824)3.63609519
8Patchy hypopigmentation of hair (HP:0011365)3.56121723
9Progressive external ophthalmoplegia (HP:0000590)3.42435239
10Dysphonia (HP:0001618)3.33460058
11Birth length less than 3rd percentile (HP:0003561)3.26270824
12Broad alveolar ridges (HP:0000187)3.21108199
13Trigonocephaly (HP:0000243)3.14477539
14Self-mutilation (HP:0000742)3.01742364
15Meckel diverticulum (HP:0002245)2.98213225
16Aplasia/Hypoplasia of the uvula (HP:0010293)2.97919389
17Intestinal atresia (HP:0011100)2.95129514
18Abnormality of the ileum (HP:0001549)2.94440705
19Septo-optic dysplasia (HP:0100842)2.86773181
20Renal duplication (HP:0000075)2.86588085
21Shoulder girdle muscle weakness (HP:0003547)2.86555850
22Pelvic girdle muscle weakness (HP:0003749)2.82963163
23Pancreatic fibrosis (HP:0100732)2.80871054
24Pheochromocytoma (HP:0002666)2.76802696
25Ependymoma (HP:0002888)2.73648947
26Pancreatic cysts (HP:0001737)2.71613354
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.70240801
28Overriding aorta (HP:0002623)2.69405930
29Insomnia (HP:0100785)2.68710062
30Chromsome breakage (HP:0040012)2.68435183
31True hermaphroditism (HP:0010459)2.67296440
32Supernumerary nipples (HP:0002558)2.66278959
33Abnormality of chromosome stability (HP:0003220)2.62219164
34Elfin facies (HP:0004428)2.60801859
35Hyperacusis (HP:0010780)2.60471517
36Renovascular hypertension (HP:0100817)2.59270648
37Beaking of vertebral bodies (HP:0004568)2.58289523
38Molar tooth sign on MRI (HP:0002419)2.56360499
39Abnormality of midbrain morphology (HP:0002418)2.56360499
40Abnormality of the hip-girdle musculature (HP:0001445)2.53631684
41Abnormality of the musculature of the pelvis (HP:0001469)2.53631684
42Nephronophthisis (HP:0000090)2.51628708
43Long clavicles (HP:0000890)2.50608092
44Sacral dimple (HP:0000960)2.47523190
45Epileptic encephalopathy (HP:0200134)2.46063744
46Abnormal lung lobation (HP:0002101)2.45612413
47Follicular hyperkeratosis (HP:0007502)2.43336024
48Glioma (HP:0009733)2.42487067
49Abnormality of the labia minora (HP:0012880)2.39495161
50Medulloblastoma (HP:0002885)2.38673365
51Neoplasm of the oral cavity (HP:0100649)2.37453140
52Degeneration of anterior horn cells (HP:0002398)2.34358046
53Abnormality of the anterior horn cell (HP:0006802)2.34358046
54Febrile seizures (HP:0002373)2.32789946
55Hemivertebrae (HP:0002937)2.31027529
56Progressive sensorineural hearing impairment (HP:0000408)2.30482443
57Long eyelashes (HP:0000527)2.29096675
58Wide nose (HP:0000445)2.28895284
59Optic nerve hypoplasia (HP:0000609)2.28433483
60Atrophy/Degeneration involving motor neurons (HP:0007373)2.25267956
61Oligodactyly (hands) (HP:0001180)2.24581371
62Volvulus (HP:0002580)2.21216354
63Aplasia/Hypoplasia of the sternum (HP:0006714)2.20760646
64Ectopic kidney (HP:0000086)2.19496189
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.18906922
66Progressive inability to walk (HP:0002505)2.18383507
67Flat cornea (HP:0007720)2.18109435
68Abnormality of the duodenum (HP:0002246)2.17578396
69Abnormality of the preputium (HP:0100587)2.17470682
70Hyperglycinemia (HP:0002154)2.16907600
71Anxiety (HP:0000739)2.16178520
72Sparse eyelashes (HP:0000653)2.15313354
73Lissencephaly (HP:0001339)2.14325461
74Abnormality of the renal medulla (HP:0100957)2.14171067
75Triphalangeal thumb (HP:0001199)2.12069138
76Small intestinal stenosis (HP:0012848)2.11173153
77Duodenal stenosis (HP:0100867)2.11173153
78Narrow nasal bridge (HP:0000446)2.10741836
79Neuroendocrine neoplasm (HP:0100634)2.10196586
80Gastrointestinal atresia (HP:0002589)2.09288188
81Abnormality of the astrocytes (HP:0100707)2.08325839
82Astrocytoma (HP:0009592)2.08325839
83Bilateral microphthalmos (HP:0007633)2.07905702
84Alopecia of scalp (HP:0002293)2.07007100
85Anencephaly (HP:0002323)2.06752090
86Stenosis of the external auditory canal (HP:0000402)2.06226107
87Narrow forehead (HP:0000341)2.04895169
88Rhabdomyosarcoma (HP:0002859)2.04538475
89Sloping forehead (HP:0000340)2.03208594
90Spinal rigidity (HP:0003306)2.01468341
91Abnormality of the diencephalon (HP:0010662)2.01088657
92Pendular nystagmus (HP:0012043)2.00753298
93Medial flaring of the eyebrow (HP:0010747)2.00502792
94Neoplasm of the adrenal cortex (HP:0100641)2.00411506
95Chronic hepatic failure (HP:0100626)1.99496636
96Sclerocornea (HP:0000647)1.97965216
97Delayed closure of the anterior fontanelle (HP:0001476)1.97369103
98Genital tract atresia (HP:0001827)1.96772092
99Wide intermamillary distance (HP:0006610)1.96432269
100Bowel diverticulosis (HP:0005222)1.95821983
101Anophthalmia (HP:0000528)1.95650052
102Papillary thyroid carcinoma (HP:0002895)1.95425618
103Focal motor seizures (HP:0011153)1.94738729
104Nasal speech (HP:0001611)1.94458282
105Abnormality of the carotid arteries (HP:0005344)1.92687313
106Thick eyebrow (HP:0000574)1.91907601
107Preaxial hand polydactyly (HP:0001177)1.91397709
108Vaginal atresia (HP:0000148)1.91042949
109Bile duct proliferation (HP:0001408)1.88178861
110Abnormal biliary tract physiology (HP:0012439)1.88178861
111Hypoplastic female external genitalia (HP:0012815)1.88129725
112Hypoplasia of the brainstem (HP:0002365)1.87664562
113Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87664562
114Cortical dysplasia (HP:0002539)1.87509212
115Agnosia (HP:0010524)1.86010055
116Abnormality of abdominal situs (HP:0011620)1.85091247
117Abdominal situs inversus (HP:0003363)1.85091247
118Renal hypoplasia (HP:0000089)1.84760035
119Patellar aplasia (HP:0006443)1.84649071
120Hepatoblastoma (HP:0002884)1.83989179
121Methylmalonic acidemia (HP:0002912)1.83406712
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.83284995
123Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83265966
124Short 4th metacarpal (HP:0010044)1.83265966
125Esophageal atresia (HP:0002032)1.82965784
126Nephroblastoma (Wilms tumor) (HP:0002667)1.82535119
127Absent radius (HP:0003974)1.82143630
128Blue irides (HP:0000635)1.81924163
129Amyotrophic lateral sclerosis (HP:0007354)1.81235487
130Megalocornea (HP:0000485)1.81147583
131Increased nuchal translucency (HP:0010880)1.81142407
132Absent septum pellucidum (HP:0001331)1.80277097
133Dandy-Walker malformation (HP:0001305)1.80252227
134Broad-based gait (HP:0002136)1.80183370
135Occipital encephalocele (HP:0002085)1.79957794
136Aplasia/Hypoplasia of the fovea (HP:0008060)1.79880554
137Hypoplasia of the fovea (HP:0007750)1.79880554
138Rimmed vacuoles (HP:0003805)1.79609326
139Polyphagia (HP:0002591)1.79091783
140Oligodactyly (HP:0012165)1.77150671
141Enlarged kidneys (HP:0000105)1.77119458
142Abnormality of the intervertebral disk (HP:0005108)1.76886266
143Aplasia involving forearm bones (HP:0009822)1.76861582
144Absent forearm bone (HP:0003953)1.76861582
145Optic nerve coloboma (HP:0000588)1.76805321
146Hypoplasia of the maxilla (HP:0000327)1.76738872
147Hyperglycinuria (HP:0003108)1.75797753
148Attention deficit hyperactivity disorder (HP:0007018)1.75742786
149Split foot (HP:0001839)1.75201472
150Aqueductal stenosis (HP:0002410)1.75126686
151Abnormal hair whorl (HP:0010721)1.74397094
152Labial hypoplasia (HP:0000066)1.73921430
153Bifid tongue (HP:0010297)1.73407526
154Nephrogenic diabetes insipidus (HP:0009806)1.73160126
155Inability to walk (HP:0002540)1.73050461
156Horseshoe kidney (HP:0000085)1.72798083
157Hypercalcemia (HP:0003072)1.72739592
158Coarse hair (HP:0002208)1.72355080
159Wide mouth (HP:0000154)1.72236297
160Sprengel anomaly (HP:0000912)1.71652685
161Aplasia/Hypoplasia of the patella (HP:0006498)1.70548439
162Flat face (HP:0012368)1.70448589
163Embryonal renal neoplasm (HP:0011794)1.70265830
164Pancreatic islet-cell hyperplasia (HP:0004510)1.70259168
165Congenital primary aphakia (HP:0007707)1.69908143
166Gait imbalance (HP:0002141)1.68736965
167Acute necrotizing encephalopathy (HP:0006965)1.68135337
168Myokymia (HP:0002411)1.67876363
169Protruding tongue (HP:0010808)1.67626290
170Abnormality of the septum pellucidum (HP:0007375)1.67090807
171Generalized amyotrophy (HP:0003700)1.66949954
172Clubbing of toes (HP:0100760)1.66791380
173Tented upper lip vermilion (HP:0010804)1.66289997
174Obsessive-compulsive behavior (HP:0000722)1.66189865
175Septate vagina (HP:0001153)1.65636191
176Abolished electroretinogram (ERG) (HP:0000550)1.63205609
177Impaired vibration sensation in the lower limbs (HP:0002166)1.63176474
178Scotoma (HP:0000575)1.62924797
179Wrist flexion contracture (HP:0001239)1.62498693
180Proximal amyotrophy (HP:0007126)1.62448257
181Acute encephalopathy (HP:0006846)1.61901484
182Focal seizures (HP:0007359)1.61513054
183Congenital stationary night blindness (HP:0007642)1.60735154
184Aplasia/Hypoplasia of the tibia (HP:0005772)1.60506459
185Absent thumb (HP:0009777)1.59545509
186Small hand (HP:0200055)1.58063168
187Cerebellar hypoplasia (HP:0001321)1.57565065
188Supernumerary spleens (HP:0009799)1.56619194
189Slow-growing hair (HP:0002217)1.55801575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK27.67940329
2TNIK6.16047624
3MKNK15.68361327
4MARK13.28766813
5ZAK2.92106394
6TRIM282.86366684
7NUAK12.75063931
8VRK12.49149822
9MAPK132.30060946
10SRPK12.20936467
11CDC72.19808844
12WEE12.10999088
13PNCK2.05968438
14EEF2K1.96071247
15TTK1.95971843
16MAP2K71.95089960
17NTRK31.93432088
18BRSK21.75714747
19CASK1.74785961
20VRK21.71710429
21NTRK21.70095556
22ADRBK21.61147392
23FRK1.60443622
24BMPR1B1.57023228
25UHMK11.56604112
26MAP4K21.55957734
27TAF11.55816611
28SIK31.54634555
29ERBB31.52085153
30MAP3K41.50098140
31DYRK21.42695695
32MINK11.33493920
33EIF2AK11.27571333
34MAP2K61.19078748
35KSR11.18440082
36PRKCG1.16310477
37PLK31.10164777
38FGFR21.09066889
39GRK11.08805559
40SGK4941.02412994
41SGK2231.02412994
42NEK21.01708358
43PBK1.00156505
44SGK20.98009818
45CDK190.94818072
46PLK20.92664646
47STK38L0.91569114
48EPHA40.91230433
49ACVR1B0.89421978
50STK30.86977899
51WNK30.85221257
52CCNB10.84825447
53CDK30.83085690
54TGFBR10.80639967
55DAPK20.79804430
56RIPK10.79747693
57DAPK10.78614104
58FGFR10.75278338
59SGK30.74432711
60NME10.73089156
61TYRO30.71322048
62AURKB0.71150920
63PLK40.70755456
64ATR0.69719063
65TIE10.69183239
66BCR0.68140716
67OXSR10.67921876
68EPHB20.67702270
69STK160.67092884
70INSRR0.66820401
71STK380.65125812
72FGFR30.65092233
73CHEK20.64138117
74STK40.63841483
75BRD40.62568416
76PHKG20.62455106
77PHKG10.62455106
78CAMK1G0.62425387
79SIK20.61570455
80EIF2AK20.59517564
81NEK10.59290655
82PRKCE0.58560286
83DYRK1A0.58404628
84CDK180.57179605
85PLK10.57179403
86BCKDK0.56500838
87CSNK1G30.56002973
88ERBB40.55057688
89MAPKAPK50.54453384
90NLK0.54393810
91IRAK40.52600119
92CSNK1A1L0.52559430
93PKN10.51977057
94PAK30.51621709
95MAP3K90.51486754
96MAP3K100.51115158
97RPS6KB10.51065518
98CDK50.50971655
99LATS10.50804487
100AURKA0.50697550
101MST40.48773484
102CDK150.47397393
103EIF2AK30.47211196
104CSNK1G20.47076492
105MAP3K120.46707605
106IRAK10.45071525
107PASK0.44389056
108PRKDC0.44246731
109CSNK1A10.44086651
110DYRK30.43550363
111CDK140.43413156
112PAK40.42953736
113ICK0.42627829
114PINK10.41703846
115TNK20.41240856
116CDK11A0.40671761
117SGK10.40027738
118CSNK1E0.39769153
119MAP2K40.39674334
120BUB10.38864910
121CDK10.37542651
122MAPK150.36532281
123RPS6KA40.35629366
124ATM0.34680376
125CSNK2A10.34382294
126PAK60.33163508
127MAPK120.33147208
128CHEK10.32796982
129CSNK1D0.31545086
130YES10.31120701
131RPS6KB20.30697600
132PRKACB0.30574945
133MAPK90.30549506
134RPS6KA50.29589077
135CLK10.29043960
136STK390.28297348
137TSSK60.27585758
138PRKG10.27355987
139GRK70.27096696
140BRSK10.26394058
141CAMK2B0.25403099
142CSNK1G10.25334397
143CDK20.25097400
144MAPKAPK30.24594537
145GSK3B0.23965100

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.85368601
2Spliceosome_Homo sapiens_hsa030402.84699886
3DNA replication_Homo sapiens_hsa030302.78370455
4Nicotine addiction_Homo sapiens_hsa050332.77019260
5Protein export_Homo sapiens_hsa030602.47495121
6Mismatch repair_Homo sapiens_hsa034302.29725267
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.24958039
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08037151
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07688110
10Glutamatergic synapse_Homo sapiens_hsa047241.96565790
11Propanoate metabolism_Homo sapiens_hsa006401.95939624
12Axon guidance_Homo sapiens_hsa043601.93655113
13Selenocompound metabolism_Homo sapiens_hsa004501.92308904
14Circadian entrainment_Homo sapiens_hsa047131.89808191
15Synaptic vesicle cycle_Homo sapiens_hsa047211.89184157
16Steroid biosynthesis_Homo sapiens_hsa001001.78208018
17Proteasome_Homo sapiens_hsa030501.72712440
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71466837
19Dopaminergic synapse_Homo sapiens_hsa047281.68915154
20Basal cell carcinoma_Homo sapiens_hsa052171.68609760
21Olfactory transduction_Homo sapiens_hsa047401.67871580
22Cell cycle_Homo sapiens_hsa041101.67501640
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65579704
24RNA degradation_Homo sapiens_hsa030181.65094277
25Morphine addiction_Homo sapiens_hsa050321.63601362
26GABAergic synapse_Homo sapiens_hsa047271.61764780
27RNA transport_Homo sapiens_hsa030131.60943797
28Long-term potentiation_Homo sapiens_hsa047201.59285538
29Butanoate metabolism_Homo sapiens_hsa006501.57999958
30One carbon pool by folate_Homo sapiens_hsa006701.56455288
31Fanconi anemia pathway_Homo sapiens_hsa034601.54522106
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54291014
33Oocyte meiosis_Homo sapiens_hsa041141.50653040
34Taste transduction_Homo sapiens_hsa047421.50114858
35mRNA surveillance pathway_Homo sapiens_hsa030151.49163165
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48617974
37Alcoholism_Homo sapiens_hsa050341.48293680
38Gap junction_Homo sapiens_hsa045401.47995381
39Parkinsons disease_Homo sapiens_hsa050121.47475459
40Oxidative phosphorylation_Homo sapiens_hsa001901.45598041
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44991911
42Circadian rhythm_Homo sapiens_hsa047101.43380773
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.39069234
44Wnt signaling pathway_Homo sapiens_hsa043101.38772724
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.36897892
46Systemic lupus erythematosus_Homo sapiens_hsa053221.33922773
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33837323
48Base excision repair_Homo sapiens_hsa034101.30408860
49Long-term depression_Homo sapiens_hsa047301.28359919
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25402969
51Serotonergic synapse_Homo sapiens_hsa047261.25249105
52Colorectal cancer_Homo sapiens_hsa052101.23575065
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21606762
54Amphetamine addiction_Homo sapiens_hsa050311.17183408
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16940630
56Cocaine addiction_Homo sapiens_hsa050301.15084519
57Melanogenesis_Homo sapiens_hsa049161.12043151
58Hedgehog signaling pathway_Homo sapiens_hsa043401.09997378
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06280765
60Ribosome_Homo sapiens_hsa030101.03929119
61Insulin secretion_Homo sapiens_hsa049111.03394956
62GnRH signaling pathway_Homo sapiens_hsa049121.02797606
63Cholinergic synapse_Homo sapiens_hsa047251.01429871
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00836505
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99686727
66Notch signaling pathway_Homo sapiens_hsa043300.97131754
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93928383
68Pyrimidine metabolism_Homo sapiens_hsa002400.93903832
69Gastric acid secretion_Homo sapiens_hsa049710.90557449
70Nucleotide excision repair_Homo sapiens_hsa034200.90430038
71Fatty acid elongation_Homo sapiens_hsa000620.89242656
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88223932
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87220110
74mTOR signaling pathway_Homo sapiens_hsa041500.86789213
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85066332
76Renin secretion_Homo sapiens_hsa049240.84686544
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.84450307
78Regulation of autophagy_Homo sapiens_hsa041400.84265406
79Oxytocin signaling pathway_Homo sapiens_hsa049210.83594291
80Hippo signaling pathway_Homo sapiens_hsa043900.81384221
81Folate biosynthesis_Homo sapiens_hsa007900.81242380
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81187364
83Peroxisome_Homo sapiens_hsa041460.78541747
84Homologous recombination_Homo sapiens_hsa034400.77919462
85Salivary secretion_Homo sapiens_hsa049700.77266352
86Non-homologous end-joining_Homo sapiens_hsa034500.77092107
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73172492
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72925678
89Ether lipid metabolism_Homo sapiens_hsa005650.72759195
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72321135
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70574648
92Linoleic acid metabolism_Homo sapiens_hsa005910.70376672
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70018283
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69744839
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69198246
96Alzheimers disease_Homo sapiens_hsa050100.68110089
97RNA polymerase_Homo sapiens_hsa030200.67939397
98TGF-beta signaling pathway_Homo sapiens_hsa043500.67645556
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67447829
100Calcium signaling pathway_Homo sapiens_hsa040200.65594815
101MAPK signaling pathway_Homo sapiens_hsa040100.65167800
102MicroRNAs in cancer_Homo sapiens_hsa052060.64530301
103p53 signaling pathway_Homo sapiens_hsa041150.61358015
104Purine metabolism_Homo sapiens_hsa002300.60930541
105ErbB signaling pathway_Homo sapiens_hsa040120.60656653
106Pyruvate metabolism_Homo sapiens_hsa006200.59993424
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.59441552
108Lysine degradation_Homo sapiens_hsa003100.58535200
109Melanoma_Homo sapiens_hsa052180.57784568
110Rap1 signaling pathway_Homo sapiens_hsa040150.57448624
111Dilated cardiomyopathy_Homo sapiens_hsa054140.57432568
112Viral myocarditis_Homo sapiens_hsa054160.55161089
113Fatty acid metabolism_Homo sapiens_hsa012120.53629522
114Metabolic pathways_Homo sapiens_hsa011000.53627187
115Tryptophan metabolism_Homo sapiens_hsa003800.53446902
116Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53267668
117Cardiac muscle contraction_Homo sapiens_hsa042600.51704518
118Phototransduction_Homo sapiens_hsa047440.51536863
119Nitrogen metabolism_Homo sapiens_hsa009100.50844082
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50459092
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47604032
122Glioma_Homo sapiens_hsa052140.47381924
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47063590
124beta-Alanine metabolism_Homo sapiens_hsa004100.44132898
125Caffeine metabolism_Homo sapiens_hsa002320.43235551
126Huntingtons disease_Homo sapiens_hsa050160.42982895
127HTLV-I infection_Homo sapiens_hsa051660.41287437
128Basal transcription factors_Homo sapiens_hsa030220.41207554
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40652903
130Vibrio cholerae infection_Homo sapiens_hsa051100.38991282
131Pathways in cancer_Homo sapiens_hsa052000.38589933
132Tight junction_Homo sapiens_hsa045300.37566630
133Autoimmune thyroid disease_Homo sapiens_hsa053200.37138956
134Epstein-Barr virus infection_Homo sapiens_hsa051690.36434877
135Collecting duct acid secretion_Homo sapiens_hsa049660.36074810
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36073428
137VEGF signaling pathway_Homo sapiens_hsa043700.35353233
138Glucagon signaling pathway_Homo sapiens_hsa049220.33160641
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32534491
140cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31591456
141Glutathione metabolism_Homo sapiens_hsa004800.30116129
142Biosynthesis of amino acids_Homo sapiens_hsa012300.29610148
143Fatty acid degradation_Homo sapiens_hsa000710.29119764
144Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26419552
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23756206
146Retinol metabolism_Homo sapiens_hsa008300.20781887
147Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17579393

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