ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.30303634
2	response to pheromone (GO:0019236)	4.91038649
3	L-fucose catabolic process (GO:0042355)	4.71136148
4	fucose catabolic process (GO:0019317)	4.71136148
5	L-fucose metabolic process (GO:0042354)	4.71136148
6	DNA deamination (GO:0045006)	4.23982622
7	cellular response to ATP (GO:0071318)	3.94052756
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.75422607
9	kynurenine metabolic process (GO:0070189)	3.70872458
10	tryptophan catabolic process (GO:0006569)	3.69514871
11	indole-containing compound catabolic process (GO:0042436)	3.69514871
12	indolalkylamine catabolic process (GO:0046218)	3.69514871
13	indolalkylamine metabolic process (GO:0006586)	3.58557797
14	platelet dense granule organization (GO:0060155)	3.46924125
15	preassembly of GPI anchor in ER membrane (GO:0016254)	3.35623209
16	cellular ketone body metabolic process (GO:0046950)	3.32770914
17	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.31367819
18	gamma-aminobutyric acid transport (GO:0015812)	3.28173218
19	primary amino compound metabolic process (GO:1901160)	3.26840016
20	epithelial cilium movement (GO:0003351)	3.21692567
21	detection of light stimulus involved in visual perception (GO:0050908)	3.18416004
22	detection of light stimulus involved in sensory perception (GO:0050962)	3.18416004
23	neuronal action potential (GO:0019228)	3.13881073
24	negative regulation of telomere maintenance (GO:0032205)	3.07411805
25	indole-containing compound metabolic process (GO:0042430)	3.04255914
26	ketone body metabolic process (GO:1902224)	2.98539914
27	mannosylation (GO:0097502)	2.96002175
28	tryptophan metabolic process (GO:0006568)	2.95198274
29	pyrimidine nucleobase catabolic process (GO:0006208)	2.94671217
30	reflex (GO:0060004)	2.91988429
31	retinal cone cell development (GO:0046549)	2.90523754
32	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.88652804
33	protein-cofactor linkage (GO:0018065)	2.88316190
34	ubiquinone biosynthetic process (GO:0006744)	2.87463200
35	serotonin metabolic process (GO:0042428)	2.86793649
36	GPI anchor metabolic process (GO:0006505)	2.84890599
37	sulfation (GO:0051923)	2.80712423
38	hindbrain development (GO:0030902)	2.79655462
39	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.78594831
40	cullin deneddylation (GO:0010388)	2.77295006
41	amine catabolic process (GO:0009310)	2.76715021
42	cellular biogenic amine catabolic process (GO:0042402)	2.76715021
43	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.74456604
44	S-adenosylmethionine metabolic process (GO:0046500)	2.73249184
45	activated T cell proliferation (GO:0050798)	2.72064881
46	ubiquinone metabolic process (GO:0006743)	2.72025885
47	behavioral response to ethanol (GO:0048149)	2.71478396
48	adaptation of signaling pathway (GO:0023058)	2.69864963
49	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.69847456
50	protein polyglutamylation (GO:0018095)	2.67784860
51	axonemal dynein complex assembly (GO:0070286)	2.66961421
52	axoneme assembly (GO:0035082)	2.65188525
53	protein deneddylation (GO:0000338)	2.63817073
54	nonmotile primary cilium assembly (GO:0035058)	2.63608949
55	neural tube formation (GO:0001841)	2.63179936
56	regulation of cilium movement (GO:0003352)	2.62301283
57	startle response (GO:0001964)	2.60461944
58	negative regulation of mast cell activation (GO:0033004)	2.60048766
59	nucleobase catabolic process (GO:0046113)	2.59821216
60	protein localization to cilium (GO:0061512)	2.58127888
61	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.57712793
62	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.57712793
63	NADH dehydrogenase complex assembly (GO:0010257)	2.57712793
64	regulation of action potential (GO:0098900)	2.56992565
65	inner ear receptor stereocilium organization (GO:0060122)	2.56858327
66	protein complex biogenesis (GO:0070271)	2.55876820
67	multicellular organism reproduction (GO:0032504)	2.55436769
68	replication fork processing (GO:0031297)	2.55378577
69	protein import into peroxisome matrix (GO:0016558)	2.55138492
70	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.54711483
71	water-soluble vitamin biosynthetic process (GO:0042364)	2.54427469
72	piRNA metabolic process (GO:0034587)	2.54199426
73	presynaptic membrane assembly (GO:0097105)	2.53896677
74	cilium or flagellum-dependent cell motility (GO:0001539)	2.53614171
75	cilium movement (GO:0003341)	2.53575291
76	respiratory chain complex IV assembly (GO:0008535)	2.51698562
77	cilium morphogenesis (GO:0060271)	2.49854869
78	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.49177617
79	cAMP catabolic process (GO:0006198)	2.48448749
80	kidney morphogenesis (GO:0060993)	2.48119415
81	protein K11-linked deubiquitination (GO:0035871)	2.45657266
82	photoreceptor cell development (GO:0042461)	2.44723163
83	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.44422144
84	cytidine metabolic process (GO:0046087)	2.43712382
85	cytidine catabolic process (GO:0006216)	2.43712382
86	cytidine deamination (GO:0009972)	2.43712382
87	cornea development in camera-type eye (GO:0061303)	2.43242698
88	postsynaptic membrane organization (GO:0001941)	2.42945105
89	regulation of neurotransmitter uptake (GO:0051580)	2.42593798
90	auditory behavior (GO:0031223)	2.42413823
91	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.42313422
92	atrial cardiac muscle cell action potential (GO:0086014)	2.42102925
93	exogenous drug catabolic process (GO:0042738)	2.41738622
94	cilium organization (GO:0044782)	2.40832968
95	positive regulation of cAMP-mediated signaling (GO:0043950)	2.38615877
96	spinal cord motor neuron differentiation (GO:0021522)	2.38600315
97	magnesium ion transport (GO:0015693)	2.35888236
98	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.35314676
99	regulation of translation, ncRNA-mediated (GO:0045974)	2.35314676
100	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.35314676

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.84782438
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.32629254
3	VDR_22108803_ChIP-Seq_LS180_Human	3.08446399
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.91627944
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.85029945
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.64851146
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.58942511
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.35112499
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.18356678
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.15422106
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14668557
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.12806345
13	EWS_26573619_Chip-Seq_HEK293_Human	2.11731161
14	P300_19829295_ChIP-Seq_ESCs_Human	2.06526137
15	FUS_26573619_Chip-Seq_HEK293_Human	2.01550327
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.98405407
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.98240760
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.96725721
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.85246760
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.77529086
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.76647424
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.73285804
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.65500656
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65464274
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.62155124
26	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.61203954
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.59281127
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58798796
29	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.56862557
30	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56724480
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.56103055
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55646320
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.55620346
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.52584682
35	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.51704488
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.50709122
37	AR_25329375_ChIP-Seq_VCAP_Human	1.50056947
38	REST_21632747_ChIP-Seq_MESCs_Mouse	1.49498984
39	STAT3_23295773_ChIP-Seq_U87_Human	1.47538548
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.46986991
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46893962
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.46893962
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.46339351
44	TCF4_23295773_ChIP-Seq_U87_Human	1.41702292
45	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.38799951
46	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.37907271
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37747836
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36804038
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35433703
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35046914
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35046914
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33542277
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33542277
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.32769251
55	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32612825
56	AR_21572438_ChIP-Seq_LNCaP_Human	1.32451030
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32403448
58	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32011375
59	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.31784600
60	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30322401
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.28861719
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28563233
63	IRF1_19129219_ChIP-ChIP_H3396_Human	1.25843630
64	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.24671541
65	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24671541
66	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.22758591
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22619321
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.22281568
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.22164726
70	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21427744
71	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.20639178
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20386163
73	NCOR_22424771_ChIP-Seq_293T_Human	1.19559984
74	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18904654
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15318411
76	AR_20517297_ChIP-Seq_VCAP_Human	1.14911159
77	TP53_16413492_ChIP-PET_HCT116_Human	1.13117961
78	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11945723
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11868546
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11826071
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11060948
82	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06810835
83	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.06726834
84	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06433552
85	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.05605599
86	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04996662
87	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.03397062
88	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.03023130
89	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02968609
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01101883
91	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00374868
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00214030
93	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.00179548
94	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.99579903
95	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.99574336
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98042632
97	MYC_19829295_ChIP-Seq_ESCs_Human	0.97427076
98	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96785095
99	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.96462310
100	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95953117

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001968_abnormal_touch/_nociception	2.98727221
2	MP0001986_abnormal_taste_sensitivity	2.96733132
3	MP0003195_calcinosis	2.79220377
4	MP0008877_abnormal_DNA_methylation	2.66608133
5	MP0006292_abnormal_olfactory_placode	2.59542311
6	MP0008872_abnormal_physiological_respon	2.35990775
7	MP0002102_abnormal_ear_morphology	2.30906941
8	MP0003880_abnormal_central_pattern	2.25812190
9	MP0002876_abnormal_thyroid_physiology	2.23123966
10	MP0005551_abnormal_eye_electrophysiolog	2.21786253
11	MP0005645_abnormal_hypothalamus_physiol	2.21770732
12	MP0009046_muscle_twitch	2.20768027
13	MP0008875_abnormal_xenobiotic_pharmacok	2.19826397
14	MP0002736_abnormal_nociception_after	2.16068282
15	MP0005646_abnormal_pituitary_gland	2.08770813
16	MP0003646_muscle_fatigue	2.00347515
17	MP0009745_abnormal_behavioral_response	1.95559616
18	MP0004142_abnormal_muscle_tone	1.95113102
19	MP0002735_abnormal_chemical_nociception	1.94144314
20	MP0006072_abnormal_retinal_apoptosis	1.86123303
21	MP0003787_abnormal_imprinting	1.84209676
22	MP0004885_abnormal_endolymph	1.81892882
23	MP0002837_dystrophic_cardiac_calcinosis	1.81551979
24	MP0005253_abnormal_eye_physiology	1.79534732
25	MP0002272_abnormal_nervous_system	1.78087189
26	MP0000427_abnormal_hair_cycle	1.75915843
27	MP0004043_abnormal_pH_regulation	1.70652784
28	MP0002733_abnormal_thermal_nociception	1.61948113
29	MP0000569_abnormal_digit_pigmentation	1.61946681
30	MP0004145_abnormal_muscle_electrophysio	1.61702880
31	MP0001486_abnormal_startle_reflex	1.54071474
32	MP0006276_abnormal_autonomic_nervous	1.52693505
33	MP0003011_delayed_dark_adaptation	1.52001044
34	MP0004133_heterotaxia	1.51953197
35	MP0003136_yellow_coat_color	1.51368614
36	MP0000631_abnormal_neuroendocrine_gland	1.51299774
37	MP0001501_abnormal_sleep_pattern	1.50974867
38	MP0002638_abnormal_pupillary_reflex	1.47735764
39	MP0002572_abnormal_emotion/affect_behav	1.46262317
40	MP0010386_abnormal_urinary_bladder	1.44307998
41	MP0002557_abnormal_social/conspecific_i	1.43145915
42	MP0001970_abnormal_pain_threshold	1.42313930
43	MP0002938_white_spotting	1.41792732
44	MP0001485_abnormal_pinna_reflex	1.39940704
45	MP0005386_behavior/neurological_phenoty	1.38795910
46	MP0004924_abnormal_behavior	1.38795910
47	MP0005084_abnormal_gallbladder_morpholo	1.35665755
48	MP0001529_abnormal_vocalization	1.33731730
49	MP0004147_increased_porphyrin_level	1.31947182
50	MP0004742_abnormal_vestibular_system	1.30786037
51	MP0005389_reproductive_system_phenotype	1.30337472
52	MP0000372_irregular_coat_pigmentation	1.28804844
53	MP0005423_abnormal_somatic_nervous	1.28431285
54	MP0003283_abnormal_digestive_organ	1.28069301
55	MP0002064_seizures	1.25818265
56	MP0002067_abnormal_sensory_capabilities	1.25533935
57	MP0001919_abnormal_reproductive_system	1.17613652
58	MP0003890_abnormal_embryonic-extraembry	1.15672627
59	MP0003635_abnormal_synaptic_transmissio	1.15527577
60	MP0002063_abnormal_learning/memory/cond	1.15353050
61	MP0005410_abnormal_fertilization	1.14006994
62	MP0002734_abnormal_mechanical_nocicepti	1.10683503
63	MP0002160_abnormal_reproductive_system	1.08274447
64	MP0002751_abnormal_autonomic_nervous	1.06161878
65	MP0005174_abnormal_tail_pigmentation	1.06053794
66	MP0002138_abnormal_hepatobiliary_system	1.05320466
67	MP0002234_abnormal_pharynx_morphology	1.05254851
68	MP0001905_abnormal_dopamine_level	1.03146164
69	MP0008995_early_reproductive_senescence	1.02066192
70	MP0003137_abnormal_impulse_conducting	1.00325071
71	MP0005671_abnormal_response_to	0.98908246
72	MP0000230_abnormal_systemic_arterial	0.97694664
73	MP0005195_abnormal_posterior_eye	0.91910803
74	MP0008775_abnormal_heart_ventricle	0.91480362
75	MP0003122_maternal_imprinting	0.90232676
76	MP0002184_abnormal_innervation	0.89330208
77	MP0003718_maternal_effect	0.89260945
78	MP0005187_abnormal_penis_morphology	0.89231890
79	MP0001984_abnormal_olfaction	0.88790602
80	MP0003121_genomic_imprinting	0.87379962
81	MP0002095_abnormal_skin_pigmentation	0.86355933
82	MP0001873_stomach_inflammation	0.84392761
83	MP0002752_abnormal_somatic_nervous	0.83200878
84	MP0001502_abnormal_circadian_rhythm	0.83085119
85	MP0001440_abnormal_grooming_behavior	0.81116672
86	MP0000778_abnormal_nervous_system	0.80299615
87	MP0000647_abnormal_sebaceous_gland	0.80093568
88	MP0002928_abnormal_bile_duct	0.79726481
89	MP0005085_abnormal_gallbladder_physiolo	0.79479579
90	MP0003698_abnormal_male_reproductive	0.78813686
91	MP0002693_abnormal_pancreas_physiology	0.76367773
92	MP0002277_abnormal_respiratory_mucosa	0.76023506
93	MP0001929_abnormal_gametogenesis	0.76012653
94	MP0005365_abnormal_bile_salt	0.72792916
95	MP0004215_abnormal_myocardial_fiber	0.72499500
96	MP0000026_abnormal_inner_ear	0.71866813
97	MP0002229_neurodegeneration	0.71638632
98	MP0000383_abnormal_hair_follicle	0.70712087
99	MP0000538_abnormal_urinary_bladder	0.69914814
100	MP0003119_abnormal_digestive_system	0.69600337

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.36287567
2	Molar tooth sign on MRI (HP:0002419)	4.24585670
3	Abnormality of midbrain morphology (HP:0002418)	4.24585670
4	Congenital stationary night blindness (HP:0007642)	3.82792326
5	Pancreatic fibrosis (HP:0100732)	3.78166320
6	Nephronophthisis (HP:0000090)	3.64896441
7	Hyperventilation (HP:0002883)	3.61922066
8	True hermaphroditism (HP:0010459)	3.58245348
9	Abnormality of the renal medulla (HP:0100957)	3.17527496
10	Abnormality of the renal cortex (HP:0011035)	3.11980645
11	Type II lissencephaly (HP:0007260)	3.10307495
12	Attenuation of retinal blood vessels (HP:0007843)	2.92951480
13	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.87185727
14	Abnormality of alanine metabolism (HP:0010916)	2.87185727
15	Hyperalaninemia (HP:0003348)	2.87185727
16	Medial flaring of the eyebrow (HP:0010747)	2.83479859
17	Large for gestational age (HP:0001520)	2.78493160
18	Cerebellar dysplasia (HP:0007033)	2.78234783
19	Pendular nystagmus (HP:0012043)	2.65156464
20	Abnormal drinking behavior (HP:0030082)	2.60306180
21	Polydipsia (HP:0001959)	2.60306180
22	Cystic liver disease (HP:0006706)	2.57328155
23	Tubular atrophy (HP:0000092)	2.55954768
24	Inability to walk (HP:0002540)	2.47896495
25	Abnormality of the pons (HP:0007361)	2.47873606
26	Abolished electroretinogram (ERG) (HP:0000550)	2.44889920
27	Congenital, generalized hypertrichosis (HP:0004540)	2.35734439
28	Hypoplasia of the pons (HP:0012110)	2.33717918
29	Lissencephaly (HP:0001339)	2.33662889
30	Acute necrotizing encephalopathy (HP:0006965)	2.33607302
31	Chronic hepatic failure (HP:0100626)	2.33427714
32	Absent speech (HP:0001344)	2.31317858
33	Decreased central vision (HP:0007663)	2.30908617
34	Keratoconus (HP:0000563)	2.28944445
35	Increased corneal curvature (HP:0100692)	2.28944445
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.22469306
37	Mitochondrial inheritance (HP:0001427)	2.21417300
38	Furrowed tongue (HP:0000221)	2.20716589
39	Focal motor seizures (HP:0011153)	2.18859619
40	Broad-based gait (HP:0002136)	2.16055570
41	Renal cortical cysts (HP:0000803)	2.14748512
42	Protruding tongue (HP:0010808)	2.14408890
43	Sclerocornea (HP:0000647)	2.14226300
44	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.13429267
45	Polyuria (HP:0000103)	2.12892446
46	Optic nerve hypoplasia (HP:0000609)	2.11459357
47	Severe muscular hypotonia (HP:0006829)	2.11327291
48	Hypothermia (HP:0002045)	2.11044875
49	Gaze-evoked nystagmus (HP:0000640)	2.10815191
50	Progressive macrocephaly (HP:0004481)	2.09387655
51	Abnormal respiratory motile cilium morphology (HP:0005938)	2.09340327
52	Abnormal respiratory epithelium morphology (HP:0012253)	2.09340327
53	Anencephaly (HP:0002323)	2.07684674
54	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.07643091
55	Acute encephalopathy (HP:0006846)	2.06565119
56	Optic disc pallor (HP:0000543)	2.04870413
57	Hepatocellular necrosis (HP:0001404)	2.04402342
58	Decreased circulating renin level (HP:0003351)	2.04101267
59	Stomach cancer (HP:0012126)	2.03606250
60	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.02881306
61	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.02481159
62	Progressive cerebellar ataxia (HP:0002073)	2.01750876
63	Increased CSF lactate (HP:0002490)	2.01547732
64	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.01528449
65	Hypoproteinemia (HP:0003075)	2.00499728
66	Gait imbalance (HP:0002141)	1.98577232
67	Colon cancer (HP:0003003)	1.98257150
68	Progressive inability to walk (HP:0002505)	1.97957298
69	Tachypnea (HP:0002789)	1.96425812
70	Congenital hepatic fibrosis (HP:0002612)	1.96322630
71	Ketoacidosis (HP:0001993)	1.96014933
72	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.94448440
73	Abnormality of macular pigmentation (HP:0008002)	1.94301846
74	Hyperglycinuria (HP:0003108)	1.93255859
75	Stomatitis (HP:0010280)	1.90731056
76	Abnormal mitochondria in muscle tissue (HP:0008316)	1.88659871
77	Hepatic necrosis (HP:0002605)	1.88223714
78	Congenital primary aphakia (HP:0007707)	1.87359059
79	Abnormality of DNA repair (HP:0003254)	1.86591600
80	Clumsiness (HP:0002312)	1.85549138
81	Retinal dysplasia (HP:0007973)	1.84631484
82	Hemiparesis (HP:0001269)	1.84055797
83	Thyroid-stimulating hormone excess (HP:0002925)	1.84024984
84	Pachygyria (HP:0001302)	1.82425872
85	Methylmalonic acidemia (HP:0002912)	1.82235548
86	Aplasia/Hypoplasia of the patella (HP:0006498)	1.82055476
87	Hypoalbuminemia (HP:0003073)	1.81403392
88	Abnormal albumin level (HP:0012116)	1.81403392
89	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.80360878
90	Absent/shortened dynein arms (HP:0200106)	1.80360878
91	Patellar aplasia (HP:0006443)	1.80339769
92	Asplenia (HP:0001746)	1.79388155
93	Methylmalonic aciduria (HP:0012120)	1.77657439
94	Male pseudohermaphroditism (HP:0000037)	1.76464613
95	Concave nail (HP:0001598)	1.73388719
96	Constricted visual fields (HP:0001133)	1.71710349
97	Abnormal urine output (HP:0012590)	1.71096177
98	Abnormality of the labia minora (HP:0012880)	1.71028937
99	Birth length less than 3rd percentile (HP:0003561)	1.70672913
100	Genital tract atresia (HP:0001827)	1.69343022

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.33472641
2	BMPR1B	3.43387345
3	CASK	3.30390257
4	ADRBK2	3.25403158
5	INSRR	3.16895920
6	NUAK1	2.93558720
7	GRK1	2.69028213
8	MAP4K2	2.53842909
9	WNK3	2.38311540
10	WNK4	2.36236307
11	ZAK	2.26992693
12	TXK	2.15735402
13	DAPK2	1.97149022
14	TNIK	1.88750211
15	ACVR1B	1.83376893
16	PINK1	1.81671650
17	TLK1	1.81003624
18	MARK1	1.73882798
19	MAPK13	1.70928578
20	OXSR1	1.63534866
21	PNCK	1.61624809
22	STK39	1.60266973
23	DYRK2	1.42577480
24	MAP3K4	1.35061989
25	ADRBK1	1.23408430
26	TAOK3	1.21195603
27	PAK3	1.21101825
28	TGFBR1	1.16982340
29	PRKCE	1.15486995
30	MKNK2	1.11759893
31	PLK4	1.05285830
32	PRKCH	1.01964697
33	PLK2	1.00326945
34	CAMKK2	0.99794547
35	PRKCG	0.99150136
36	MAP2K7	0.98382655
37	VRK2	0.98178156
38	NTRK3	0.94967837
39	TRIM28	0.86944689
40	VRK1	0.84201210
41	MST4	0.82747085
42	MAPK15	0.81061565
43	IKBKB	0.76701844
44	TIE1	0.75392619
45	PTK2B	0.75328694
46	PHKG2	0.73140284
47	PHKG1	0.73140284
48	STK38L	0.71431796
49	PIK3CA	0.70568089
50	PRKCQ	0.69987608
51	MAP2K6	0.69328061
52	CAMK2A	0.67069136
53	IRAK1	0.65321583
54	EPHA4	0.59954954
55	ERBB3	0.56462750
56	NTRK2	0.56073659
57	GRK7	0.55790666
58	PBK	0.54981058
59	MAP2K2	0.54973415
60	TEC	0.53943894
61	CSNK1G2	0.53781065
62	DYRK3	0.53775003
63	RPS6KA5	0.52712554
64	ITK	0.51501194
65	SIK2	0.50982131
66	NME1	0.50799963
67	MKNK1	0.48340509
68	MUSK	0.47874732
69	PRKACA	0.47351369
70	BCKDK	0.46568532
71	PRKCI	0.46258523
72	PKN1	0.46234025
73	STK11	0.45260301
74	KIT	0.45086763
75	CSNK1G1	0.43501384
76	PLK3	0.42629966
77	TAF1	0.42264893
78	NLK	0.42103047
79	SGK2	0.41953438
80	FGFR2	0.40655823
81	CSNK1G3	0.40439557
82	EPHA3	0.39673872
83	PRKCA	0.37635182
84	EIF2AK3	0.37437363
85	BCR	0.37332718
86	CSNK1A1L	0.37263244
87	CHUK	0.36993852
88	CSNK1A1	0.36603481
89	MAPKAPK3	0.36529192
90	SGK494	0.36179321
91	SGK223	0.36179321
92	CCNB1	0.36037359
93	SYK	0.35967961
94	CAMK1	0.35881739
95	WNK1	0.35297695
96	BRSK2	0.35093662
97	DAPK1	0.32788292
98	MAP2K1	0.32700224
99	CDK8	0.31892673
100	PRKG1	0.31618075

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.83393313
2	Phototransduction_Homo sapiens_hsa04744	2.73320487
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.57209519
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.44312837
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.39052728
6	Nicotine addiction_Homo sapiens_hsa05033	2.37547637
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.35783811
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.35622087
9	Butanoate metabolism_Homo sapiens_hsa00650	2.26988884
10	RNA polymerase_Homo sapiens_hsa03020	2.22287177
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.18588322
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.14109395
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.13614571
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.07588265
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.04448474
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.92823609
17	Parkinsons disease_Homo sapiens_hsa05012	1.86930886
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.84628409
19	Caffeine metabolism_Homo sapiens_hsa00232	1.81569836
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.80661476
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.78437354
22	Protein export_Homo sapiens_hsa03060	1.72014673
23	Taste transduction_Homo sapiens_hsa04742	1.53997464
24	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.51614618
25	Homologous recombination_Homo sapiens_hsa03440	1.41043088
26	Olfactory transduction_Homo sapiens_hsa04740	1.40835755
27	Morphine addiction_Homo sapiens_hsa05032	1.38910531
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.38142661
29	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.31540102
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.30938176
31	ABC transporters_Homo sapiens_hsa02010	1.30835147
32	Propanoate metabolism_Homo sapiens_hsa00640	1.26336053
33	Regulation of autophagy_Homo sapiens_hsa04140	1.22547760
34	Basal transcription factors_Homo sapiens_hsa03022	1.19771560
35	Huntingtons disease_Homo sapiens_hsa05016	1.19640325
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.18228624
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.17095154
38	Peroxisome_Homo sapiens_hsa04146	1.15910382
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.12365100
40	Alzheimers disease_Homo sapiens_hsa05010	1.08720754
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.07735452
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.07069194
43	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.06885781
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.02868510
45	RNA degradation_Homo sapiens_hsa03018	1.02813487
46	Circadian entrainment_Homo sapiens_hsa04713	1.02749161
47	Insulin secretion_Homo sapiens_hsa04911	0.98957318
48	Serotonergic synapse_Homo sapiens_hsa04726	0.96355006
49	GABAergic synapse_Homo sapiens_hsa04727	0.90831514
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.90772322
51	One carbon pool by folate_Homo sapiens_hsa00670	0.88713983
52	Primary immunodeficiency_Homo sapiens_hsa05340	0.87870763
53	Glutamatergic synapse_Homo sapiens_hsa04724	0.87843858
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87326152
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.83359199
56	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.81965779
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.81836563
58	Retinol metabolism_Homo sapiens_hsa00830	0.81042213
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.79417742
60	Steroid biosynthesis_Homo sapiens_hsa00100	0.76660468
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.76149353
62	Purine metabolism_Homo sapiens_hsa00230	0.75900771
63	Type I diabetes mellitus_Homo sapiens_hsa04940	0.73061794
64	Asthma_Homo sapiens_hsa05310	0.70544329
65	Glycerolipid metabolism_Homo sapiens_hsa00561	0.69715255
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.67796728
67	Salivary secretion_Homo sapiens_hsa04970	0.67684178
68	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.66666638
69	Sulfur metabolism_Homo sapiens_hsa00920	0.65947031
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.65478995
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65072139
72	Graft-versus-host disease_Homo sapiens_hsa05332	0.64363443
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.62820577
74	Calcium signaling pathway_Homo sapiens_hsa04020	0.62187674
75	Proteasome_Homo sapiens_hsa03050	0.62160144
76	Metabolic pathways_Homo sapiens_hsa01100	0.60272914
77	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.59354888
78	Allograft rejection_Homo sapiens_hsa05330	0.57778467
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.56221250
80	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.56138661
81	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.55331381
82	Pyrimidine metabolism_Homo sapiens_hsa00240	0.54408544
83	Histidine metabolism_Homo sapiens_hsa00340	0.50998170
84	Dopaminergic synapse_Homo sapiens_hsa04728	0.49629153
85	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.49344778
86	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.49217410
87	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.48541299
88	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.47945392
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.47305504
90	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47093285
91	Mineral absorption_Homo sapiens_hsa04978	0.45838470
92	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.44670608
93	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.43175151
94	Long-term depression_Homo sapiens_hsa04730	0.38757003
95	Cocaine addiction_Homo sapiens_hsa05030	0.38423878
96	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.36878066
97	Circadian rhythm_Homo sapiens_hsa04710	0.36210338
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.32536628
99	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.32085539
100	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.31658188

ZIK1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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