ZIM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In human, ZIM2 and PEG3 (GeneID:5178) are two distinct genes that share a set of 5' exons and have a common promoter, and both genes are paternally expressed. Alternative splicing events connect the shared exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. This is in contrast to mouse and cow, where ZIM2 and PEG3 genes do not share exons in common, and the imprinting status of ZIM2 is also not conserved amongst mammals. Additional 5' alternatively spliced transcripts encoding the same protein have been found for the human ZIM2 gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)8.58029375
2acrosome reaction (GO:0007340)8.07772368
3centriole replication (GO:0007099)7.40278825
4fusion of sperm to egg plasma membrane (GO:0007342)7.06576210
5protein polyglutamylation (GO:0018095)6.58568623
6protein targeting to Golgi (GO:0000042)6.54745641
7multicellular organism reproduction (GO:0032504)6.47761843
8chromosome condensation (GO:0030261)6.27220241
9establishment of protein localization to Golgi (GO:0072600)6.26791438
10retrograde transport, vesicle recycling within Golgi (GO:0000301)6.12131845
11spermatid development (GO:0007286)6.07868520
12microtubule depolymerization (GO:0007019)6.06047529
13centriole assembly (GO:0098534)5.99633840
14DNA packaging (GO:0006323)5.99175771
15spermatid nucleus differentiation (GO:0007289)5.95399212
16sperm capacitation (GO:0048240)5.91064840
17microtubule polymerization or depolymerization (GO:0031109)5.73337066
18sperm-egg recognition (GO:0035036)5.62701758
19single strand break repair (GO:0000012)5.39910312
20spermatogenesis (GO:0007283)5.33564994
21male gamete generation (GO:0048232)5.32623135
22reproduction (GO:0000003)5.28566116
23plasma membrane fusion (GO:0045026)5.26268078
24piRNA metabolic process (GO:0034587)5.14479305
25binding of sperm to zona pellucida (GO:0007339)5.11207898
26gamete generation (GO:0007276)5.01095425
27regulation of centriole replication (GO:0046599)4.92195783
28calcium ion-dependent exocytosis (GO:0017156)4.80644222
29rRNA methylation (GO:0031167)4.79780638
30seminiferous tubule development (GO:0072520)4.71767836
31regulation of meiosis I (GO:0060631)4.65759164
32DNA methylation involved in gamete generation (GO:0043046)4.64914824
33negative regulation of inclusion body assembly (GO:0090084)4.64213493
34protein localization to Golgi apparatus (GO:0034067)4.63363171
35microtubule severing (GO:0051013)4.54780557
36cell-cell recognition (GO:0009988)4.52152784
37single fertilization (GO:0007338)4.48957890
38axonemal dynein complex assembly (GO:0070286)4.38585076
39fertilization (GO:0009566)4.35897516
40phosphatidylethanolamine biosynthetic process (GO:0006646)4.33488259
41epithelial cilium movement (GO:0003351)4.17256001
42cilium or flagellum-dependent cell motility (GO:0001539)4.14204902
43regulation of cilium movement (GO:0003352)4.13749545
44phosphatidylethanolamine metabolic process (GO:0046337)4.06118292
45germ cell development (GO:0007281)4.00833016
46regulation of female gonad development (GO:2000194)3.98798164
47regulation of inclusion body assembly (GO:0090083)3.96507904
48multicellular organismal reproductive process (GO:0048609)3.94539668
49microtubule nucleation (GO:0007020)3.88620600
50rRNA modification (GO:0000154)3.83491267
51cellular process involved in reproduction in multicellular organism (GO:0022412)3.75168537
52RNA destabilization (GO:0050779)3.74050242
53glomerular visceral epithelial cell development (GO:0072015)3.72951748
54nucleus organization (GO:0006997)3.63331010
55meiotic cell cycle (GO:0051321)3.57783747
56cilium movement (GO:0003341)3.55793783
57male meiosis I (GO:0007141)3.50619487
58cell wall macromolecule catabolic process (GO:0016998)3.50233962
59multicellular organismal movement (GO:0050879)3.44325520
60musculoskeletal movement (GO:0050881)3.44325520
61regulation of microtubule-based movement (GO:0060632)3.42295230
62motile cilium assembly (GO:0044458)3.42151533
63response to pheromone (GO:0019236)3.42058932
64centrosome duplication (GO:0051298)3.41993174
65glomerular epithelial cell development (GO:0072310)3.37859754
66retinal cone cell development (GO:0046549)3.32357407
67male meiosis (GO:0007140)3.30772441
68cell wall macromolecule metabolic process (GO:0044036)3.28326098
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26044872
70synapsis (GO:0007129)3.23814031
71regulation of acrosome reaction (GO:0060046)3.21673594
72C4-dicarboxylate transport (GO:0015740)3.19882612
73regulation of Rab GTPase activity (GO:0032313)3.15067435
74positive regulation of Rab GTPase activity (GO:0032851)3.15067435
75nuclear pore complex assembly (GO:0051292)3.09532371
76regulation of DNA methylation (GO:0044030)3.06568940
77negative regulation of histone methylation (GO:0031061)2.97651377
78phosphorelay signal transduction system (GO:0000160)2.94405158
79positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.93813286
80positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.93813286
81positive regulation of mitotic sister chromatid separation (GO:1901970)2.93813286
82histone H3-K9 demethylation (GO:0033169)2.89593176
83sexual reproduction (GO:0019953)2.88010445
84female gamete generation (GO:0007292)2.84291886
85vesicle transport along microtubule (GO:0047496)2.79414486
86regulation of timing of cell differentiation (GO:0048505)2.79268905
87regulation of centrosome cycle (GO:0046605)2.77867308
88chromosome organization involved in meiosis (GO:0070192)2.76503040
89Golgi to endosome transport (GO:0006895)2.75894382
90regulation of male gonad development (GO:2000018)2.72143946
91oogenesis (GO:0048477)2.71419101
92regulation of centrosome duplication (GO:0010824)2.69121942
93regulation of histone H3-K9 methylation (GO:0051570)2.68387029
94axoneme assembly (GO:0035082)2.67773695
95meiosis I (GO:0007127)2.65624614
96meiotic cell cycle process (GO:1903046)2.65444434
97RNA localization (GO:0006403)2.64352927
98resolution of meiotic recombination intermediates (GO:0000712)2.63873756
99cerebral cortex neuron differentiation (GO:0021895)2.63860772
100histone mRNA catabolic process (GO:0071044)2.63489699

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.67529972
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.14494415
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.75350877
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.64027501
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.58251353
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53699816
7GBX2_23144817_ChIP-Seq_PC3_Human2.51185240
8FUS_26573619_Chip-Seq_HEK293_Human2.50079400
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.49094237
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49059989
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.46128389
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44526800
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.44526800
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.26712824
15IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.10552402
16CBP_20019798_ChIP-Seq_JUKART_Human2.10552402
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01770227
18VDR_22108803_ChIP-Seq_LS180_Human2.01748353
19UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.99780415
20P300_19829295_ChIP-Seq_ESCs_Human1.97409790
21SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.88956456
22SMAD3_21741376_ChIP-Seq_EPCs_Human1.80786576
23* SMAD4_21799915_ChIP-Seq_A2780_Human1.75111517
24AR_25329375_ChIP-Seq_VCAP_Human1.74716361
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70510491
26SMAD4_21741376_ChIP-Seq_EPCs_Human1.69526561
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69329740
28ARNT_22903824_ChIP-Seq_MCF-7_Human1.68975469
29TOP2B_26459242_ChIP-Seq_MCF-7_Human1.67458305
30ER_23166858_ChIP-Seq_MCF-7_Human1.66481696
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66107164
32* STAT3_23295773_ChIP-Seq_U87_Human1.65656243
33TAF15_26573619_Chip-Seq_HEK293_Human1.65405053
34* ZNF274_21170338_ChIP-Seq_K562_Hela1.61753473
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60823149
36DROSHA_22980978_ChIP-Seq_HELA_Human1.54772454
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54644651
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54135231
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46713415
40TCF4_23295773_ChIP-Seq_U87_Human1.44218533
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43798623
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39157895
43TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38832313
44TCF4_18268006_ChIP-ChIP_LS174T_Human1.37137105
45AR_21572438_ChIP-Seq_LNCaP_Human1.36819296
46RUNX2_22187159_ChIP-Seq_PCA_Human1.35988292
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34818175
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30835237
49AHR_22903824_ChIP-Seq_MCF-7_Human1.30540537
50* TP63_19390658_ChIP-ChIP_HaCaT_Human1.29966885
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29578286
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28332339
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.27187954
54TP53_18474530_ChIP-ChIP_U2OS_Human1.26869582
55TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24589764
56KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22645257
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.22259543
58SMAD3_21741376_ChIP-Seq_ESCs_Human1.21761532
59WDR5_24793694_ChIP-Seq_LNCAP_Human1.21277871
60KDM2B_26808549_Chip-Seq_REH_Human1.20438763
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.19821982
62CBX2_22325352_ChIP-Seq_293T-Rex_Human1.19003231
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18445215
64TBL1_22424771_ChIP-Seq_293T_Human1.16848240
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15787686
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15681506
67MYC_19829295_ChIP-Seq_ESCs_Human1.14480143
68SMAD4_21741376_ChIP-Seq_HESCs_Human1.14302350
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13677477
70TCF4_22108803_ChIP-Seq_LS180_Human1.12068729
71SOX2_19829295_ChIP-Seq_ESCs_Human1.11460039
72NANOG_19829295_ChIP-Seq_ESCs_Human1.11460039
73REST_21632747_ChIP-Seq_MESCs_Mouse1.10890048
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.10210770
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.08788763
76CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08359574
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08293734
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07666866
79PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06108133
80NFYB_21822215_ChIP-Seq_K562_Human1.05687896
81ETV1_20927104_ChIP-Seq_GIST48_Human1.05681540
82* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03288117
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00981328
84NANOG_20526341_ChIP-Seq_ESCs_Human1.00284879
85HNFA_21074721_ChIP-Seq_CACO-2_Human0.99623035
86TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98727999
87BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98663966
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98446086
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98444722
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96857035
91EWS_26573619_Chip-Seq_HEK293_Human0.94572042
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93268851
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93244353
94RBPJ_21746931_ChIP-Seq_IB4_Human0.92131853
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92063201
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.90973339
97PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90610300
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90492306
99OCT1_27270436_Chip-Seq_PROSTATE_Human0.90323301
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90127727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.60441371
2MP0003718_maternal_effect4.23662103
3MP0005377_hearing/vestibular/ear_phenot3.58714499
4MP0003878_abnormal_ear_physiology3.58714499
5MP0001929_abnormal_gametogenesis3.46096126
6MP0003698_abnormal_male_reproductive3.41861101
7MP0008877_abnormal_DNA_methylation3.07315051
8MP0001984_abnormal_olfaction2.36614209
9MP0000566_synostosis2.34186071
10MP0006292_abnormal_olfactory_placode2.29765680
11MP0005670_abnormal_white_adipose2.22223340
12MP0002210_abnormal_sex_determination2.19145808
13MP0002161_abnormal_fertility/fecundity2.15576486
14MP0001486_abnormal_startle_reflex2.11721489
15MP0008789_abnormal_olfactory_epithelium2.00037885
16MP0001485_abnormal_pinna_reflex1.88655109
17MP0005379_endocrine/exocrine_gland_phen1.86497007
18MP0005551_abnormal_eye_electrophysiolog1.86282343
19MP0004742_abnormal_vestibular_system1.80146153
20MP0005423_abnormal_somatic_nervous1.71029685
21MP0000653_abnormal_sex_gland1.67344029
22MP0005394_taste/olfaction_phenotype1.63109694
23MP0005499_abnormal_olfactory_system1.63109694
24MP0005395_other_phenotype1.62930816
25MP0001145_abnormal_male_reproductive1.60224504
26MP0004859_abnormal_synaptic_plasticity1.55276360
27MP0003879_abnormal_hair_cell1.45786415
28MP0004270_analgesia1.44152790
29MP0002234_abnormal_pharynx_morphology1.35988596
30MP0003950_abnormal_plasma_membrane1.32607764
31MP0003880_abnormal_central_pattern1.28206383
32MP0001963_abnormal_hearing_physiology1.20846154
33MP0001968_abnormal_touch/_nociception1.20711008
34MP0002272_abnormal_nervous_system1.18927106
35MP0002735_abnormal_chemical_nociception1.18670133
36MP0005253_abnormal_eye_physiology1.16013423
37MP0002067_abnormal_sensory_capabilities1.15336953
38MP0001348_abnormal_lacrimal_gland1.15333611
39MP0002557_abnormal_social/conspecific_i1.14358115
40MP0003122_maternal_imprinting1.12650677
41MP0003121_genomic_imprinting1.11281378
42MP0003646_muscle_fatigue1.10993417
43MP0002282_abnormal_trachea_morphology1.10420669
44MP0005360_urolithiasis1.08203250
45MP0000534_abnormal_ureter_morphology1.06880377
46MP0000026_abnormal_inner_ear1.04947508
47MP0005367_renal/urinary_system_phenotyp1.01454095
48MP0000516_abnormal_urinary_system1.01454095
49MP0008058_abnormal_DNA_repair1.00403654
50MP0003699_abnormal_female_reproductive0.99890437
51MP0008995_early_reproductive_senescence0.98641052
52MP0002572_abnormal_emotion/affect_behav0.98032565
53MP0006276_abnormal_autonomic_nervous0.97895542
54MP0002127_abnormal_cardiovascular_syste0.97879956
55MP0009745_abnormal_behavioral_response0.95554681
56MP0000778_abnormal_nervous_system0.94703650
57MP0001666_abnormal_nutrient_absorption0.94098752
58MP0010329_abnormal_lipoprotein_level0.92166611
59MP0003635_abnormal_synaptic_transmissio0.91258083
60MP0004215_abnormal_myocardial_fiber0.90894972
61MP0009697_abnormal_copulation0.90745018
62MP0005310_abnormal_salivary_gland0.89542759
63MP0008569_lethality_at_weaning0.88901393
64MP0002229_neurodegeneration0.88720162
65MP0003077_abnormal_cell_cycle0.88502049
66MP0003119_abnormal_digestive_system0.87132751
67MP0010094_abnormal_chromosome_stability0.85589449
68MP0000955_abnormal_spinal_cord0.84610349
69MP0002734_abnormal_mechanical_nocicepti0.83107089
70MP0002138_abnormal_hepatobiliary_system0.82843691
71MP0009115_abnormal_fat_cell0.79613069
72MP0010368_abnormal_lymphatic_system0.78437672
73MP0003136_yellow_coat_color0.77726440
74MP0002139_abnormal_hepatobiliary_system0.77536963
75MP0003890_abnormal_embryonic-extraembry0.74256019
76MP0000631_abnormal_neuroendocrine_gland0.73928600
77MP0005391_vision/eye_phenotype0.72950007
78MP0002736_abnormal_nociception_after0.72437308
79MP0004084_abnormal_cardiac_muscle0.70814749
80MP0001501_abnormal_sleep_pattern0.70455216
81MP0000049_abnormal_middle_ear0.70257514
82MP0003011_delayed_dark_adaptation0.70076286
83MP0000678_abnormal_parathyroid_gland0.69832412
84MP0002233_abnormal_nose_morphology0.69315559
85MP0004085_abnormal_heartbeat0.69250653
86MP0002063_abnormal_learning/memory/cond0.67527935
87MP0002160_abnormal_reproductive_system0.66694323
88MP0009780_abnormal_chondrocyte_physiolo0.66371980
89MP0002882_abnormal_neuron_morphology0.66164481
90MP0010307_abnormal_tumor_latency0.64900794
91MP0003935_abnormal_craniofacial_develop0.64544439
92MP0008875_abnormal_xenobiotic_pharmacok0.64221445
93MP0004885_abnormal_endolymph0.63479098
94MP0001119_abnormal_female_reproductive0.63188055
95MP0009384_cardiac_valve_regurgitation0.62948228
96MP0003861_abnormal_nervous_system0.62884713
97MP0001286_abnormal_eye_development0.62130196
98MP0002249_abnormal_larynx_morphology0.62125453
99MP0002752_abnormal_somatic_nervous0.61934884
100MP0001765_abnormal_ion_homeostasis0.61870809

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)6.02495271
2Tubulointerstitial nephritis (HP:0001970)5.80879395
3Absent/shortened dynein arms (HP:0200106)4.68069905
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.68069905
5Severe visual impairment (HP:0001141)4.39320738
6Cone-rod dystrophy (HP:0000548)3.78114541
7Male infertility (HP:0003251)3.73417365
8Impulsivity (HP:0100710)3.67359729
9Abnormal ciliary motility (HP:0012262)3.65055215
10Infertility (HP:0000789)3.37087039
11Hypoalphalipoproteinemia (HP:0003233)3.35651413
12Abnormal respiratory motile cilium physiology (HP:0012261)3.34002541
13Nephronophthisis (HP:0000090)3.16758072
14Abnormal respiratory motile cilium morphology (HP:0005938)3.11664721
15Abnormal respiratory epithelium morphology (HP:0012253)3.11664721
16Abnormality of macular pigmentation (HP:0008002)3.11171281
17Progressive cerebellar ataxia (HP:0002073)3.09705363
18Tubulointerstitial abnormality (HP:0001969)3.09587889
19Asymmetric septal hypertrophy (HP:0001670)3.07243526
20Bony spicule pigmentary retinopathy (HP:0007737)3.06283207
21Aplasia/Hypoplasia of the earlobes (HP:0009906)3.06071237
22Attenuation of retinal blood vessels (HP:0007843)3.01465829
23Truncal obesity (HP:0001956)2.97852294
24Hyperkalemia (HP:0002153)2.92455097
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.84965776
26Progressive sensorineural hearing impairment (HP:0000408)2.81053124
27Osteomalacia (HP:0002749)2.78796948
28Portal hypertension (HP:0001409)2.78715384
29Menstrual irregularities (HP:0000858)2.78708448
30Renovascular hypertension (HP:0100817)2.77137801
31Abnormality of the renal medulla (HP:0100957)2.73732143
32Optic nerve hypoplasia (HP:0000609)2.71432947
33Azoospermia (HP:0000027)2.67448029
34Supernumerary spleens (HP:0009799)2.59609445
35Abnormality of the hepatic vasculature (HP:0006707)2.51725139
36Hypophosphatemic rickets (HP:0004912)2.48819241
37Intellectual disability, moderate (HP:0002342)2.45872375
38Abnormal spermatogenesis (HP:0008669)2.44332141
39Stage 5 chronic kidney disease (HP:0003774)2.43848586
40Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.42521343
41Myokymia (HP:0002411)2.28939951
42Resting tremor (HP:0002322)2.28097977
43Generalized aminoaciduria (HP:0002909)2.25946559
44Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.25198362
45Midline defect of the nose (HP:0004122)2.24800973
46Subcapsular cataract (HP:0000523)2.22815829
47Abnormal rod and cone electroretinograms (HP:0008323)2.21419870
48Facial shape deformation (HP:0011334)2.20507942
49Potter facies (HP:0002009)2.20507942
50Atonic seizures (HP:0010819)2.20189035
51Postural instability (HP:0002172)2.19189513
52Abnormality of midbrain morphology (HP:0002418)2.15922706
53Molar tooth sign on MRI (HP:0002419)2.15922706
54Hypolipoproteinemia (HP:0010981)2.14316562
55Abnormality of lateral ventricle (HP:0030047)2.12558792
56Morphological abnormality of the inner ear (HP:0011390)2.12189428
57Abnormality of cochlea (HP:0000375)2.11986315
58Congenital sensorineural hearing impairment (HP:0008527)2.11108475
59Polydipsia (HP:0001959)2.09289680
60Abnormal drinking behavior (HP:0030082)2.09289680
61Tubular atrophy (HP:0000092)2.08001948
62True hermaphroditism (HP:0010459)2.05660408
63Facial hemangioma (HP:0000329)2.02694229
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.00738383
65Pancreatic fibrosis (HP:0100732)2.00665444
66Aplasia/Hypoplasia of the sternum (HP:0006714)2.00460438
67Rhinitis (HP:0012384)1.99807257
68Abnormality of the ileum (HP:0001549)1.98461964
69Abnormal urine output (HP:0012590)1.97970163
70Hypoplastic ischia (HP:0003175)1.96136990
71Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.94625800
72Meckel diverticulum (HP:0002245)1.94129311
73Septo-optic dysplasia (HP:0100842)1.94078382
74Pancreatic cysts (HP:0001737)1.93275581
75Abnormality of the labia minora (HP:0012880)1.93272458
76Abnormality of the renal cortex (HP:0011035)1.92110009
77Amelogenesis imperfecta (HP:0000705)1.91417435
78Febrile seizures (HP:0002373)1.89894780
79Hypoplastic iliac wings (HP:0002866)1.88855172
80Abnormality of dental color (HP:0011073)1.88273224
81Insulin-resistant diabetes mellitus (HP:0000831)1.87272874
82Abdominal situs inversus (HP:0003363)1.86874806
83Abnormality of abdominal situs (HP:0011620)1.86874806
84Abnormality of the ischium (HP:0003174)1.84956033
85Oligodactyly (hands) (HP:0001180)1.84179936
86Bell-shaped thorax (HP:0001591)1.82335504
87Volvulus (HP:0002580)1.76855526
88Neoplasm of striated muscle (HP:0009728)1.76723671
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.76030957
90Nasal polyposis (HP:0100582)1.75728635
91Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.73630144
92Small intestinal stenosis (HP:0012848)1.73190592
93Duodenal stenosis (HP:0100867)1.73190592
94Focal motor seizures (HP:0011153)1.71961973
95Horizontal nystagmus (HP:0000666)1.69348159
96Abnormality of potassium homeostasis (HP:0011042)1.69118929
97Abnormality of urine glucose concentration (HP:0011016)1.68775936
98Glycosuria (HP:0003076)1.68775936
99Rhabdomyosarcoma (HP:0002859)1.68743272
100Occipital encephalocele (HP:0002085)1.67492435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.51685085
2PNCK4.24471413
3BRD43.74424260
4INSRR3.45632471
5STK38L3.18611552
6PLK23.16118041
7CAMK1G2.13637376
8FRK2.12163718
9WNK12.07089315
10MAP4K21.96724573
11STK381.96509295
12MAP3K91.90514542
13WNK31.77378244
14TYRO31.71842601
15FGFR21.68173884
16TESK11.64207539
17NEK61.62976024
18AKT31.53106871
19CDC71.52577449
20DDR21.42510133
21PIK3CG1.35545799
22CDK121.34621774
23STK391.34035408
24NTRK31.29476114
25MAPK151.27658136
26PTK2B1.27371497
27MARK11.25168049
28CDK31.16343585
29PRKD31.12210107
30PDK11.08176270
31TNIK1.08152952
32BMPR1B1.07444707
33NTRK21.04463413
34PINK11.03828529
35TIE11.02853115
36TAOK31.02648974
37BRSK21.00367162
38CAMK1D0.93542620
39BRSK10.91960976
40CDK70.90235054
41MKNK20.89566386
42BRAF0.89134127
43EPHA40.88332998
44PKN10.87554349
45CCNB10.87461050
46PDPK10.85214551
47WNK40.84642449
48MAPK130.83996254
49PRKG10.77726082
50LATS10.74559655
51WEE10.73399649
52TTK0.73338210
53ROCK10.72578889
54ARAF0.70424812
55PLK10.70348284
56MET0.67778929
57PLK30.66348968
58CDK10.62148757
59PRKCZ0.61878475
60FGFR30.60897866
61TSSK60.59590467
62NUAK10.58906088
63CDK20.57692913
64PRKCG0.57236243
65KSR20.56795093
66PRKAA20.54632359
67MAP3K130.53627736
68GSK3B0.53422150
69SGK20.53354888
70CSNK1D0.50443440
71MAP3K40.49856633
72AURKA0.47720771
73SGK4940.45656929
74SGK2230.45656929
75CAMK10.45530323
76OXSR10.44710872
77DYRK1B0.44609649
78MAPK80.44222245
79CASK0.43619558
80ACVR1B0.42893012
81NEK20.40428830
82CHEK10.40095938
83ATM0.38953419
84MAPK10.36761961
85LATS20.34771197
86SGK10.33854371
87CDK50.33539260
88RPS6KA10.32057554
89SIK20.31628209
90CAMK2A0.31276212
91UHMK10.30894913
92FGFR10.30515064
93PRKACA0.29827837
94MUSK0.29780262
95MTOR0.28502859
96STK30.28350794
97MAPK100.28027263
98PRKG20.27958783
99PRKACB0.26803429
100MAPK140.26413021

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.06476202
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.42199659
3Olfactory transduction_Homo sapiens_hsa047403.32281370
4Fanconi anemia pathway_Homo sapiens_hsa034602.38636999
5Taste transduction_Homo sapiens_hsa047422.10594155
6Nicotine addiction_Homo sapiens_hsa050332.07493110
7Phototransduction_Homo sapiens_hsa047442.07263507
8Dorso-ventral axis formation_Homo sapiens_hsa043202.01755392
9Basal transcription factors_Homo sapiens_hsa030221.79719980
10RNA transport_Homo sapiens_hsa030131.78844487
11Oocyte meiosis_Homo sapiens_hsa041141.78409572
12Glutamatergic synapse_Homo sapiens_hsa047241.64637629
13Morphine addiction_Homo sapiens_hsa050321.63089718
14Ovarian steroidogenesis_Homo sapiens_hsa049131.52622744
15Nitrogen metabolism_Homo sapiens_hsa009101.51455636
16Butanoate metabolism_Homo sapiens_hsa006501.50625832
17Glycerophospholipid metabolism_Homo sapiens_hsa005641.50342087
18Hedgehog signaling pathway_Homo sapiens_hsa043401.46886458
19Fatty acid degradation_Homo sapiens_hsa000711.44358380
20ABC transporters_Homo sapiens_hsa020101.43026724
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33956670
22Cell cycle_Homo sapiens_hsa041101.33586384
23Circadian entrainment_Homo sapiens_hsa047131.32338293
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32286089
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31952739
26Fatty acid metabolism_Homo sapiens_hsa012121.24455585
27Circadian rhythm_Homo sapiens_hsa047101.21278089
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19169742
29GABAergic synapse_Homo sapiens_hsa047271.15735307
30Bile secretion_Homo sapiens_hsa049761.14181223
31Propanoate metabolism_Homo sapiens_hsa006401.13868291
32PPAR signaling pathway_Homo sapiens_hsa033201.11759914
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10525892
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04527305
35cAMP signaling pathway_Homo sapiens_hsa040241.03990678
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.03447005
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01588199
38Fat digestion and absorption_Homo sapiens_hsa049751.00462342
39Salivary secretion_Homo sapiens_hsa049700.98780087
40Inositol phosphate metabolism_Homo sapiens_hsa005620.97716527
41Primary bile acid biosynthesis_Homo sapiens_hsa001200.96807494
42Calcium signaling pathway_Homo sapiens_hsa040200.95062642
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93565190
44Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90429737
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.87976881
46Protein digestion and absorption_Homo sapiens_hsa049740.87148162
47Serotonergic synapse_Homo sapiens_hsa047260.87111123
48Insulin secretion_Homo sapiens_hsa049110.86728239
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85883481
50Long-term potentiation_Homo sapiens_hsa047200.85858137
51Retinol metabolism_Homo sapiens_hsa008300.84619283
52Tryptophan metabolism_Homo sapiens_hsa003800.84412168
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82734063
54Amphetamine addiction_Homo sapiens_hsa050310.81804670
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81638737
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81407098
57Glycerolipid metabolism_Homo sapiens_hsa005610.81121281
58Long-term depression_Homo sapiens_hsa047300.79644932
59Arginine biosynthesis_Homo sapiens_hsa002200.77577672
60Arginine and proline metabolism_Homo sapiens_hsa003300.77084328
61Renin secretion_Homo sapiens_hsa049240.76749208
62Synaptic vesicle cycle_Homo sapiens_hsa047210.76556235
63Mismatch repair_Homo sapiens_hsa034300.75057392
64Lysine degradation_Homo sapiens_hsa003100.74394540
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72895311
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72694186
67Tight junction_Homo sapiens_hsa045300.71315898
68Gastric acid secretion_Homo sapiens_hsa049710.70867726
69Wnt signaling pathway_Homo sapiens_hsa043100.67544579
70Estrogen signaling pathway_Homo sapiens_hsa049150.65328821
71Steroid biosynthesis_Homo sapiens_hsa001000.64660616
72Adherens junction_Homo sapiens_hsa045200.64275984
73mRNA surveillance pathway_Homo sapiens_hsa030150.61505176
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61201482
75RNA degradation_Homo sapiens_hsa030180.60971193
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60154036
77Cardiac muscle contraction_Homo sapiens_hsa042600.59986925
78Nucleotide excision repair_Homo sapiens_hsa034200.58894276
79Cholinergic synapse_Homo sapiens_hsa047250.58797123
80Phenylalanine metabolism_Homo sapiens_hsa003600.55165777
81Base excision repair_Homo sapiens_hsa034100.54119071
82Homologous recombination_Homo sapiens_hsa034400.54021474
83Pancreatic secretion_Homo sapiens_hsa049720.52750020
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52569474
85Complement and coagulation cascades_Homo sapiens_hsa046100.51949813
86Cocaine addiction_Homo sapiens_hsa050300.50847131
87Caffeine metabolism_Homo sapiens_hsa002320.50761792
88Oxytocin signaling pathway_Homo sapiens_hsa049210.50687445
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.50475350
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50081310
91Non-homologous end-joining_Homo sapiens_hsa034500.49587971
92Linoleic acid metabolism_Homo sapiens_hsa005910.48760885
93Tyrosine metabolism_Homo sapiens_hsa003500.47197369
94Hippo signaling pathway_Homo sapiens_hsa043900.46654703
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46215955
96Histidine metabolism_Homo sapiens_hsa003400.44830356
97Dopaminergic synapse_Homo sapiens_hsa047280.44330157
98Type II diabetes mellitus_Homo sapiens_hsa049300.41914650
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41773325
100Gap junction_Homo sapiens_hsa045400.40951225

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