ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	8.28886449
2	regulation of retinoic acid receptor signaling pathway (GO:0048385)	7.07319208
3	behavioral response to nicotine (GO:0035095)	5.13422623
4	fucose catabolic process (GO:0019317)	4.73034478
5	L-fucose metabolic process (GO:0042354)	4.73034478
6	L-fucose catabolic process (GO:0042355)	4.73034478
7	DNA deamination (GO:0045006)	4.61026894
8	protein-cofactor linkage (GO:0018065)	4.32774818
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.98189707
10	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.87277228
11	male meiosis I (GO:0007141)	3.76547675
12	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.69712193
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.69712193
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.52847568
15	piRNA metabolic process (GO:0034587)	3.50983691
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.40553943
17	NADH dehydrogenase complex assembly (GO:0010257)	3.40553943
18	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.40553943
19	preassembly of GPI anchor in ER membrane (GO:0016254)	3.34129185
20	maturation of 5.8S rRNA (GO:0000460)	3.30926935
21	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.29722697
22	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.29014891
23	protein complex biogenesis (GO:0070271)	3.26078446
24	respiratory chain complex IV assembly (GO:0008535)	3.21906485
25	pseudouridine synthesis (GO:0001522)	3.18004420
26	cellular ketone body metabolic process (GO:0046950)	3.16126145
27	platelet dense granule organization (GO:0060155)	3.15196813
28	epithelial cilium movement (GO:0003351)	3.13501133
29	neuron fate determination (GO:0048664)	3.10618527
30	mitochondrial respiratory chain complex assembly (GO:0033108)	3.09614744
31	negative regulation of telomere maintenance (GO:0032205)	3.07579178
32	nephron epithelium morphogenesis (GO:0072088)	3.04260295
33	nephron tubule morphogenesis (GO:0072078)	3.04260295
34	meiosis I (GO:0007127)	3.03382724
35	negative regulation of mast cell activation (GO:0033004)	3.02451112
36	rRNA modification (GO:0000154)	3.00977513
37	protein K6-linked ubiquitination (GO:0085020)	3.00288654
38	ketone body metabolic process (GO:1902224)	3.00261147
39	chaperone-mediated protein transport (GO:0072321)	2.98039925
40	indolalkylamine metabolic process (GO:0006586)	2.95561905
41	multicellular organism reproduction (GO:0032504)	2.95493152
42	ATP synthesis coupled proton transport (GO:0015986)	2.94776456
43	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.94776456
44	male meiosis (GO:0007140)	2.93717739
45	kidney morphogenesis (GO:0060993)	2.90809081
46	protein K11-linked deubiquitination (GO:0035871)	2.90405480
47	tRNA processing (GO:0008033)	2.89277705
48	DNA methylation involved in gamete generation (GO:0043046)	2.86767835
49	termination of RNA polymerase III transcription (GO:0006386)	2.86059542
50	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.86059542
51	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.83943444
52	ubiquinone biosynthetic process (GO:0006744)	2.83396165
53	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.83117796
54	auditory receptor cell stereocilium organization (GO:0060088)	2.82193172
55	reciprocal DNA recombination (GO:0035825)	2.77594196
56	reciprocal meiotic recombination (GO:0007131)	2.77594196
57	indole-containing compound catabolic process (GO:0042436)	2.74509469
58	indolalkylamine catabolic process (GO:0046218)	2.74509469
59	tryptophan catabolic process (GO:0006569)	2.74509469
60	regulation of cilium movement (GO:0003352)	2.73937942
61	tRNA modification (GO:0006400)	2.73167927
62	positive regulation of protein homooligomerization (GO:0032464)	2.70940670
63	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.70591097
64	axoneme assembly (GO:0035082)	2.70236737
65	DNA double-strand break processing (GO:0000729)	2.69836472
66	rRNA catabolic process (GO:0016075)	2.67800269
67	mannosylation (GO:0097502)	2.67714041
68	peptidyl-histidine modification (GO:0018202)	2.67578000
69	cilium morphogenesis (GO:0060271)	2.65148454
70	ubiquinone metabolic process (GO:0006743)	2.64159934
71	rRNA methylation (GO:0031167)	2.63619719
72	cytochrome complex assembly (GO:0017004)	2.63604845
73	kynurenine metabolic process (GO:0070189)	2.63531386
74	recombinational repair (GO:0000725)	2.62763296
75	photoreceptor cell development (GO:0042461)	2.62688989
76	nonmotile primary cilium assembly (GO:0035058)	2.62457254
77	protein polyglutamylation (GO:0018095)	2.60792283
78	fucosylation (GO:0036065)	2.60281206
79	double-strand break repair via homologous recombination (GO:0000724)	2.58661149
80	response to pheromone (GO:0019236)	2.57729818
81	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.55005884
82	cilium movement (GO:0003341)	2.54985669
83	positive regulation of prostaglandin secretion (GO:0032308)	2.54712873
84	retinal cone cell development (GO:0046549)	2.52844837
85	mitochondrial RNA metabolic process (GO:0000959)	2.52323630
86	replication fork processing (GO:0031297)	2.49585657
87	intracellular protein transmembrane import (GO:0044743)	2.48863869
88	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.45142090
89	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.43845140
90	GPI anchor metabolic process (GO:0006505)	2.43067572
91	detection of light stimulus involved in sensory perception (GO:0050962)	2.43006867
92	detection of light stimulus involved in visual perception (GO:0050908)	2.43006867
93	protein neddylation (GO:0045116)	2.41670222
94	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.41420746
95	tryptophan metabolic process (GO:0006568)	2.41189297
96	cornea development in camera-type eye (GO:0061303)	2.40821151
97	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.39276491
98	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.38422718
99	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.38282706
100	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.37537924

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.50191295
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.41517609
3	VDR_22108803_ChIP-Seq_LS180_Human	3.31940208
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.02795844
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.87651737
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.84298468
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.78473435
8	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.64640788
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.55920435
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.46355562
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.14458645
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.12330701
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.03605508
14	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.98137146
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.95095343
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92530945
17	EWS_26573619_Chip-Seq_HEK293_Human	1.91713103
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.90160980
19	IGF1R_20145208_ChIP-Seq_DFB_Human	1.89599599
20	TP53_22573176_ChIP-Seq_HFKS_Human	1.89579642
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89230207
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.89066820
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.88490355
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.85620828
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.83972133
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.80735604
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.78673961
28	P300_19829295_ChIP-Seq_ESCs_Human	1.72819495
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.67614270
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.64091936
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.61991127
32	FUS_26573619_Chip-Seq_HEK293_Human	1.59684449
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58234598
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.51939923
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.51618247
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.45356994
37	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40398870
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33287368
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33287368
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.32654184
41	TAF15_26573619_Chip-Seq_HEK293_Human	1.32060936
42	HOXB7_26014856_ChIP-Seq_BT474_Human	1.31724155
43	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.31435777
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.31254203
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30606579
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30606579
47	FOXP3_21729870_ChIP-Seq_TREG_Human	1.28808969
48	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.27323901
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26594637
50	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26249577
51	NCOR_22424771_ChIP-Seq_293T_Human	1.25740083
52	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.25636900
53	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.22138193
54	AR_20517297_ChIP-Seq_VCAP_Human	1.22132355
55	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.18853740
56	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.18534011
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.16336789
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14889262
59	* STAT3_23295773_ChIP-Seq_U87_Human	1.12504008
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.12114380
61	CBP_20019798_ChIP-Seq_JUKART_Human	1.12093535
62	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12093535
63	AR_25329375_ChIP-Seq_VCAP_Human	1.11250961
64	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.10471658
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09255256
66	PHF8_20622853_ChIP-Seq_HELA_Human	1.09166848
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08383076
68	MYC_19829295_ChIP-Seq_ESCs_Human	1.08132945
69	ETV1_20927104_ChIP-Seq_GIST48_Human	1.07294453
70	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.06817986
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06478959
72	* NANOG_20526341_ChIP-Seq_ESCs_Human	1.06272037
73	RBPJ_21746931_ChIP-Seq_IB4_Human	1.05694396
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05651281
75	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.05143580
76	TCF4_23295773_ChIP-Seq_U87_Human	1.04968631
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03918242
78	SMAD4_21799915_ChIP-Seq_A2780_Human	1.03758826
79	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03633920
80	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.02859077
81	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02627841
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01145693
83	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.00879344
84	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00282324
85	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.99201005
86	ERA_21632823_ChIP-Seq_H3396_Human	0.98911728
87	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.98664420
88	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97970793
89	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97924004
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97808943
91	RNF2_27304074_Chip-Seq_NSC_Mouse	0.97413621
92	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97008191
93	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.96122234
94	GATA3_26560356_Chip-Seq_TH2_Human	0.95541668
95	NFYB_21822215_ChIP-Seq_K562_Human	0.94406979
96	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.94177249
97	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94152656
98	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.94152656
99	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.93732768
100	P53_21459846_ChIP-Seq_SAOS-2_Human	0.93610484

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001986_abnormal_taste_sensitivity	3.47895740
2	MP0008877_abnormal_DNA_methylation	3.00527330
3	MP0006292_abnormal_olfactory_placode	2.99374626
4	MP0002102_abnormal_ear_morphology	2.83188469
5	MP0002837_dystrophic_cardiac_calcinosis	2.65557556
6	MP0003646_muscle_fatigue	2.50663185
7	MP0000372_irregular_coat_pigmentation	2.36799980
8	MP0005551_abnormal_eye_electrophysiolog	2.25229974
9	MP0003195_calcinosis	2.21094305
10	MP0004147_increased_porphyrin_level	2.17208429
11	MP0006072_abnormal_retinal_apoptosis	2.07314533
12	MP0002638_abnormal_pupillary_reflex	2.06506676
13	MP0002938_white_spotting	1.97477967
14	MP0003136_yellow_coat_color	1.95332236
15	MP0001968_abnormal_touch/_nociception	1.92749387
16	MP0008872_abnormal_physiological_respon	1.91479386
17	MP0002163_abnormal_gland_morphology	1.90518961
18	MP0005084_abnormal_gallbladder_morpholo	1.84099309
19	MP0005645_abnormal_hypothalamus_physiol	1.82333704
20	MP0003787_abnormal_imprinting	1.82066707
21	MP0005646_abnormal_pituitary_gland	1.77414424
22	MP0008875_abnormal_xenobiotic_pharmacok	1.76269547
23	MP0005423_abnormal_somatic_nervous	1.75843215
24	MP0002138_abnormal_hepatobiliary_system	1.71329882
25	MP0004885_abnormal_endolymph	1.69720804
26	MP0005075_abnormal_melanosome_morpholog	1.68263135
27	MP0005253_abnormal_eye_physiology	1.66164907
28	MP0005379_endocrine/exocrine_gland_phen	1.65458836
29	MP0003718_maternal_effect	1.64674039
30	MP0002876_abnormal_thyroid_physiology	1.60163776
31	MP0004142_abnormal_muscle_tone	1.57780121
32	MP0003011_delayed_dark_adaptation	1.55209774
33	MP0006276_abnormal_autonomic_nervous	1.51472961
34	MP0001984_abnormal_olfaction	1.48257022
35	MP0009745_abnormal_behavioral_response	1.46843886
36	MP0002095_abnormal_skin_pigmentation	1.45488861
37	MP0004043_abnormal_pH_regulation	1.45049987
38	MP0008058_abnormal_DNA_repair	1.42518593
39	MP0000631_abnormal_neuroendocrine_gland	1.41788978
40	MP0000427_abnormal_hair_cycle	1.40281547
41	MP0002736_abnormal_nociception_after	1.39941218
42	MP0002653_abnormal_ependyma_morphology	1.38673416
43	MP0009046_muscle_twitch	1.38558331
44	MP0001501_abnormal_sleep_pattern	1.35592758
45	MP0005389_reproductive_system_phenotype	1.35042310
46	MP0002160_abnormal_reproductive_system	1.33759999
47	MP0002234_abnormal_pharynx_morphology	1.32650948
48	MP0003122_maternal_imprinting	1.31895534
49	MP0003121_genomic_imprinting	1.28552049
50	MP0000569_abnormal_digit_pigmentation	1.25966093
51	MP0001486_abnormal_startle_reflex	1.23958099
52	MP0004133_heterotaxia	1.23241425
53	MP0002272_abnormal_nervous_system	1.22971449
54	MP0005377_hearing/vestibular/ear_phenot	1.20365135
55	MP0003878_abnormal_ear_physiology	1.20365135
56	MP0008789_abnormal_olfactory_epithelium	1.17422575
57	MP0002928_abnormal_bile_duct	1.15201319
58	MP0002277_abnormal_respiratory_mucosa	1.14667314
59	MP0005174_abnormal_tail_pigmentation	1.10933209
60	MP0001919_abnormal_reproductive_system	1.10658729
61	MP0001529_abnormal_vocalization	1.10098476
62	MP0001293_anophthalmia	1.09308416
63	MP0000015_abnormal_ear_pigmentation	1.08550040
64	MP0003880_abnormal_central_pattern	1.06341173
65	MP0002572_abnormal_emotion/affect_behav	1.03456773
66	MP0003806_abnormal_nucleotide_metabolis	1.01469498
67	MP0000026_abnormal_inner_ear	0.99306614
68	MP0005394_taste/olfaction_phenotype	0.98277726
69	MP0005499_abnormal_olfactory_system	0.98277726
70	MP0001905_abnormal_dopamine_level	0.96705807
71	MP0001764_abnormal_homeostasis	0.96468277
72	MP0008995_early_reproductive_senescence	0.96008041
73	MP0001485_abnormal_pinna_reflex	0.94378938
74	MP0001324_abnormal_eye_pigmentation	0.94306840
75	MP0005195_abnormal_posterior_eye	0.94017357
76	MP0002210_abnormal_sex_determination	0.93954835
77	MP0006036_abnormal_mitochondrial_physio	0.93915449
78	MP0002735_abnormal_chemical_nociception	0.93691299
79	MP0005167_abnormal_blood-brain_barrier	0.93131767
80	MP0001929_abnormal_gametogenesis	0.92007119
81	MP0002557_abnormal_social/conspecific_i	0.91777136
82	MP0003186_abnormal_redox_activity	0.91718031
83	MP0004145_abnormal_muscle_electrophysio	0.90254529
84	MP0003283_abnormal_digestive_organ	0.89714337
85	MP0002733_abnormal_thermal_nociception	0.87091161
86	MP0005410_abnormal_fertilization	0.84803928
87	MP0003786_premature_aging	0.84411724
88	MP0002064_seizures	0.82520387
89	MP0004742_abnormal_vestibular_system	0.82165597
90	MP0005220_abnormal_exocrine_pancreas	0.81940094
91	MP0001970_abnormal_pain_threshold	0.80510921
92	MP0004924_abnormal_behavior	0.80341111
93	MP0005386_behavior/neurological_phenoty	0.80341111
94	MP0003698_abnormal_male_reproductive	0.79339086
95	MP0000049_abnormal_middle_ear	0.78494059
96	MP0002067_abnormal_sensory_capabilities	0.77116076
97	MP0001502_abnormal_circadian_rhythm	0.76990962
98	MP0002751_abnormal_autonomic_nervous	0.76144306
99	MP0005408_hypopigmentation	0.75608177
100	MP0000230_abnormal_systemic_arterial	0.75272510

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.69988663
2	Pancreatic fibrosis (HP:0100732)	4.35984716
3	Congenital stationary night blindness (HP:0007642)	4.17697532
4	Abnormality of midbrain morphology (HP:0002418)	3.77487714
5	Molar tooth sign on MRI (HP:0002419)	3.77487714
6	True hermaphroditism (HP:0010459)	3.69491341
7	Abnormal drinking behavior (HP:0030082)	3.31940960
8	Polydipsia (HP:0001959)	3.31940960
9	Nephronophthisis (HP:0000090)	3.31067609
10	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.24203250
11	Abnormality of alanine metabolism (HP:0010916)	3.24203250
12	Hyperalaninemia (HP:0003348)	3.24203250
13	Abnormality of the renal cortex (HP:0011035)	3.20154873
14	Type II lissencephaly (HP:0007260)	3.14169399
15	Tubular atrophy (HP:0000092)	3.10428915
16	Abnormality of the renal medulla (HP:0100957)	3.05294351
17	Attenuation of retinal blood vessels (HP:0007843)	2.84580728
18	Cystic liver disease (HP:0006706)	2.80353025
19	Lipid accumulation in hepatocytes (HP:0006561)	2.79659196
20	Abolished electroretinogram (ERG) (HP:0000550)	2.75067375
21	Bile duct proliferation (HP:0001408)	2.71720730
22	Abnormal biliary tract physiology (HP:0012439)	2.71720730
23	Medial flaring of the eyebrow (HP:0010747)	2.68710003
24	Pendular nystagmus (HP:0012043)	2.67945131
25	Acute necrotizing encephalopathy (HP:0006965)	2.63026497
26	Mitochondrial inheritance (HP:0001427)	2.60140070
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.59666483
28	Increased hepatocellular lipid droplets (HP:0006565)	2.57370620
29	Increased CSF lactate (HP:0002490)	2.57015370
30	Polyuria (HP:0000103)	2.54608226
31	Aplasia/hypoplasia of the uterus (HP:0008684)	2.45339229
32	Chronic hepatic failure (HP:0100626)	2.45113878
33	Congenital, generalized hypertrichosis (HP:0004540)	2.45077940
34	Acute encephalopathy (HP:0006846)	2.35849159
35	Concave nail (HP:0001598)	2.25879970
36	Abnormal number of erythroid precursors (HP:0012131)	2.24091209
37	Sclerocornea (HP:0000647)	2.23441909
38	Congenital hepatic fibrosis (HP:0002612)	2.23113595
39	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.22289383
40	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.18574854
41	Inability to walk (HP:0002540)	2.18419716
42	Progressive macrocephaly (HP:0004481)	2.18228256
43	Hypoplasia of the uterus (HP:0000013)	2.17501561
44	Abnormal mitochondria in muscle tissue (HP:0008316)	2.17444446
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.15996557
46	Keratoconus (HP:0000563)	2.15522701
47	Increased corneal curvature (HP:0100692)	2.15522701
48	Methylmalonic acidemia (HP:0002912)	2.13027205
49	Progressive inability to walk (HP:0002505)	2.11088010
50	Optic nerve hypoplasia (HP:0000609)	2.10755030
51	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.10159610
52	Birth length less than 3rd percentile (HP:0003561)	2.09148147
53	Optic disc pallor (HP:0000543)	2.06006461
54	Abnormal respiratory epithelium morphology (HP:0012253)	2.05548453
55	Abnormal respiratory motile cilium morphology (HP:0005938)	2.05548453
56	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.05062064
57	Lissencephaly (HP:0001339)	2.04883743
58	Methylmalonic aciduria (HP:0012120)	2.04069981
59	Male pseudohermaphroditism (HP:0000037)	2.03980124
60	Abnormal urine output (HP:0012590)	2.03927476
61	Abnormality of urine glucose concentration (HP:0011016)	2.02820257
62	Glycosuria (HP:0003076)	2.02820257
63	Hypoplasia of the fovea (HP:0007750)	2.02318834
64	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.02318834
65	Hyperventilation (HP:0002883)	2.02302243
66	Decreased central vision (HP:0007663)	2.02051855
67	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.01895779
68	Increased serum lactate (HP:0002151)	2.01135922
69	Gait imbalance (HP:0002141)	1.99732273
70	Chorioretinal atrophy (HP:0000533)	1.98878941
71	3-Methylglutaconic aciduria (HP:0003535)	1.98303366
72	Anencephaly (HP:0002323)	1.98159641
73	Nephrogenic diabetes insipidus (HP:0009806)	1.97620508
74	Congenital primary aphakia (HP:0007707)	1.97432609
75	Asplenia (HP:0001746)	1.96307499
76	Abnormality of cells of the erythroid lineage (HP:0012130)	1.94673588
77	Abnormality of the labia minora (HP:0012880)	1.94098572
78	Constricted visual fields (HP:0001133)	1.93783970
79	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.92778159
80	Renal Fanconi syndrome (HP:0001994)	1.90030656
81	Renal cortical cysts (HP:0000803)	1.88697703
82	Patellar aplasia (HP:0006443)	1.88059967
83	Aplasia/Hypoplasia of the patella (HP:0006498)	1.87729720
84	Retinal dysplasia (HP:0007973)	1.87028249
85	Hepatocellular necrosis (HP:0001404)	1.86165114
86	Abnormality of the renal collecting system (HP:0004742)	1.85196685
87	Duplicated collecting system (HP:0000081)	1.85054961
88	Hepatic necrosis (HP:0002605)	1.84537325
89	Cerebellar dysplasia (HP:0007033)	1.83488468
90	Abnormality of the pons (HP:0007361)	1.83329340
91	Postaxial foot polydactyly (HP:0001830)	1.82049616
92	Short tibia (HP:0005736)	1.82045536
93	Large for gestational age (HP:0001520)	1.81707135
94	Abnormality of the fovea (HP:0000493)	1.78625780
95	Supernumerary spleens (HP:0009799)	1.76429016
96	Abnormality of renal excretion (HP:0011036)	1.76128783
97	Polyphagia (HP:0002591)	1.75129004
98	Hypomagnesemia (HP:0002917)	1.74781745
99	Tubulointerstitial fibrosis (HP:0005576)	1.73861622
100	Hypoplasia of the pons (HP:0012110)	1.73831017

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.97147701
2	ADRBK2	3.54224631
3	TAOK3	3.22509860
4	TLK1	2.78075591
5	MAP4K2	2.71058415
6	WNK4	2.59607569
7	ZAK	2.56384047
8	WNK3	2.47715463
9	GRK1	2.43094675
10	BMPR1B	2.37677440
11	PINK1	2.30079446
12	NUAK1	2.27464464
13	INSRR	2.01053787
14	ACVR1B	1.86754028
15	TXK	1.79963256
16	STK39	1.60768667
17	TRIM28	1.55663626
18	OXSR1	1.49042188
19	CASK	1.45715149
20	CDK19	1.43810795
21	DYRK2	1.39464892
22	STK16	1.38169148
23	DAPK2	1.36029884
24	MST4	1.35510734
25	MAPK13	1.33558902
26	BCKDK	1.29198288
27	TIE1	1.25194268
28	BUB1	1.25182263
29	VRK2	1.23492539
30	MAP3K4	1.22750684
31	VRK1	1.17345400
32	ADRBK1	1.11281068
33	PLK3	1.09087824
34	PASK	1.04918817
35	TSSK6	1.01235061
36	TGFBR1	0.95897260
37	MKNK2	0.90154353
38	MAP2K7	0.88953195
39	PLK2	0.88306655
40	SRPK1	0.84874526
41	PRKCG	0.82228784
42	PHKG1	0.81839627
43	PHKG2	0.81839627
44	EIF2AK3	0.81135542
45	PLK4	0.80274966
46	BRSK2	0.80197889
47	PRKCE	0.80131322
48	NTRK2	0.77686394
49	PAK3	0.76112352
50	MAP2K6	0.75712819
51	PLK1	0.74247424
52	STK11	0.73853797
53	BCR	0.73268195
54	IKBKB	0.71848919
55	EPHA3	0.71047979
56	NME1	0.69552896
57	KIT	0.68972760
58	CAMKK2	0.68780555
59	PRKCQ	0.68385516
60	CSNK1G1	0.67821389
61	MUSK	0.65584572
62	PIK3CA	0.65111087
63	NEK2	0.64099902
64	ATR	0.62351014
65	CSNK1G3	0.62085920
66	CSNK1G2	0.58831389
67	MAPKAPK5	0.58681258
68	RPS6KA5	0.58038640
69	PRKCI	0.57509813
70	CSNK1A1	0.54517461
71	MARK3	0.54087220
72	STK3	0.53983621
73	PDK2	0.53827225
74	MAPKAPK3	0.53800263
75	WEE1	0.52929599
76	PRKACA	0.50037977
77	CAMK2A	0.49003116
78	CSNK1A1L	0.47756803
79	PTK2B	0.47381042
80	IRAK1	0.47006974
81	MKNK1	0.46401335
82	TEC	0.46150846
83	NTRK3	0.44074135
84	MAPK15	0.42733778
85	MARK1	0.41635438
86	OBSCN	0.40400894
87	PRKG1	0.39881800
88	CHEK2	0.39880470
89	CSNK2A1	0.39270507
90	MAP2K2	0.39157390
91	PRKCA	0.38756015
92	PRKCZ	0.37996084
93	PKN1	0.37882365
94	EPHA4	0.36809809
95	NEK1	0.35282176
96	TNIK	0.34345397
97	CDK3	0.30531452
98	AURKB	0.30019818
99	EIF2AK2	0.29857566
100	FGFR2	0.29790669

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	2.65243115
2	RNA polymerase_Homo sapiens_hsa03020	2.63111519
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.59423354
4	Phototransduction_Homo sapiens_hsa04744	2.48093632
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.45404404
6	Homologous recombination_Homo sapiens_hsa03440	2.40736897
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.34038586
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.26150975
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.24145063
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.20877649
11	Parkinsons disease_Homo sapiens_hsa05012	2.10941587
12	Protein export_Homo sapiens_hsa03060	2.07730995
13	Nitrogen metabolism_Homo sapiens_hsa00910	2.05017979
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.00043329
15	Butanoate metabolism_Homo sapiens_hsa00650	1.97642345
16	Ribosome_Homo sapiens_hsa03010	1.90728568
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.86862747
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.86837343
19	Proteasome_Homo sapiens_hsa03050	1.77053011
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.75971305
21	RNA degradation_Homo sapiens_hsa03018	1.74657798
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.69754813
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.61060382
24	One carbon pool by folate_Homo sapiens_hsa00670	1.59040401
25	Caffeine metabolism_Homo sapiens_hsa00232	1.58472284
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.58252916
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.56752889
28	Huntingtons disease_Homo sapiens_hsa05016	1.48959178
29	Regulation of autophagy_Homo sapiens_hsa04140	1.48640731
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.47488990
31	Sulfur relay system_Homo sapiens_hsa04122	1.46933207
32	Nicotine addiction_Homo sapiens_hsa05033	1.39714855
33	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.37145025
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.30726077
35	Olfactory transduction_Homo sapiens_hsa04740	1.25349397
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.23049298
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.22399106
38	Propanoate metabolism_Homo sapiens_hsa00640	1.17425619
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.16454374
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.15465334
41	Alzheimers disease_Homo sapiens_hsa05010	1.15461134
42	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.14449228
43	Taste transduction_Homo sapiens_hsa04742	1.12329915
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.10072913
45	Pyrimidine metabolism_Homo sapiens_hsa00240	1.06269552
46	Peroxisome_Homo sapiens_hsa04146	1.03156070
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.00217135
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98547828
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.97115916
50	Morphine addiction_Homo sapiens_hsa05032	0.95840800
51	Purine metabolism_Homo sapiens_hsa00230	0.95772517
52	RNA transport_Homo sapiens_hsa03013	0.93480358
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.93356408
54	Asthma_Homo sapiens_hsa05310	0.88588683
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.87846787
56	Sulfur metabolism_Homo sapiens_hsa00920	0.85603256
57	Primary immunodeficiency_Homo sapiens_hsa05340	0.85283189
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.84056093
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81536221
60	Insulin secretion_Homo sapiens_hsa04911	0.79820483
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.76321260
62	Nucleotide excision repair_Homo sapiens_hsa03420	0.74920230
63	Mismatch repair_Homo sapiens_hsa03430	0.73486976
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72576991
65	Serotonergic synapse_Homo sapiens_hsa04726	0.70156050
66	ABC transporters_Homo sapiens_hsa02010	0.69184831
67	Metabolic pathways_Homo sapiens_hsa01100	0.67908345
68	Retinol metabolism_Homo sapiens_hsa00830	0.67220428
69	GABAergic synapse_Homo sapiens_hsa04727	0.65273746
70	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.64547813
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64292118
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.62074118
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.60489803
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.59828189
75	Type I diabetes mellitus_Homo sapiens_hsa04940	0.59001818
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.58813613
77	Non-homologous end-joining_Homo sapiens_hsa03450	0.58659778
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55872556
79	Circadian entrainment_Homo sapiens_hsa04713	0.55342211
80	Spliceosome_Homo sapiens_hsa03040	0.54079910
81	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.54020034
82	Folate biosynthesis_Homo sapiens_hsa00790	0.51668375
83	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.47472988
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46592489
85	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.45675830
86	Mineral absorption_Homo sapiens_hsa04978	0.41602913
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40846761
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40530403
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.40426900
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39180635
91	Allograft rejection_Homo sapiens_hsa05330	0.38083505
92	Base excision repair_Homo sapiens_hsa03410	0.37268810
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37210114
94	DNA replication_Homo sapiens_hsa03030	0.37013664
95	p53 signaling pathway_Homo sapiens_hsa04115	0.36935149
96	Salivary secretion_Homo sapiens_hsa04970	0.35316366
97	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.35177966
98	Rheumatoid arthritis_Homo sapiens_hsa05323	0.33084328
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.32834946
100	Glutathione metabolism_Homo sapiens_hsa00480	0.32678757

ZIM3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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