ZKSCAN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.70551230
2indole-containing compound catabolic process (GO:0042436)5.17862311
3indolalkylamine catabolic process (GO:0046218)5.17862311
4tryptophan catabolic process (GO:0006569)5.17862311
5L-phenylalanine catabolic process (GO:0006559)5.14061335
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.14061335
7aromatic amino acid family catabolic process (GO:0009074)5.05534217
8tryptophan metabolic process (GO:0006568)5.02357425
9L-phenylalanine metabolic process (GO:0006558)4.41487922
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.41487922
11cellular biogenic amine catabolic process (GO:0042402)4.33325378
12amine catabolic process (GO:0009310)4.33325378
13L-fucose catabolic process (GO:0042355)4.30034940
14fucose catabolic process (GO:0019317)4.30034940
15L-fucose metabolic process (GO:0042354)4.30034940
16kynurenine metabolic process (GO:0070189)4.17790008
17bile acid biosynthetic process (GO:0006699)4.07789647
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.97417113
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.93192701
20urea cycle (GO:0000050)3.89152786
21urea metabolic process (GO:0019627)3.89152786
22complement activation, alternative pathway (GO:0006957)3.87126568
23response to pheromone (GO:0019236)3.84115934
24cellular ketone body metabolic process (GO:0046950)3.82639668
25regulation of protein activation cascade (GO:2000257)3.81253650
26indolalkylamine metabolic process (GO:0006586)3.79804434
27negative regulation of telomere maintenance (GO:0032205)3.79410028
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.78903509
29detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.73015349
30negative regulation of lipase activity (GO:0060192)3.72667903
31alpha-linolenic acid metabolic process (GO:0036109)3.66819880
32glyoxylate metabolic process (GO:0046487)3.59884679
33phospholipid homeostasis (GO:0055091)3.59845047
34regulation of complement activation (GO:0030449)3.57651265
35bile acid metabolic process (GO:0008206)3.52600092
36high-density lipoprotein particle remodeling (GO:0034375)3.48526038
37nitrogen cycle metabolic process (GO:0071941)3.42729352
38ketone body metabolic process (GO:1902224)3.42391012
39epithelial cilium movement (GO:0003351)3.40189876
40amino-acid betaine metabolic process (GO:0006577)3.35473117
41very-low-density lipoprotein particle assembly (GO:0034379)3.32555113
42neural tube formation (GO:0001841)3.31696033
43kidney morphogenesis (GO:0060993)3.31643959
44triglyceride homeostasis (GO:0070328)3.31611831
45acylglycerol homeostasis (GO:0055090)3.31611831
46reverse cholesterol transport (GO:0043691)3.31492841
47water-soluble vitamin biosynthetic process (GO:0042364)3.30616284
48aromatic amino acid family metabolic process (GO:0009072)3.29189699
49negative regulation of protein activation cascade (GO:2000258)3.28976575
50detection of light stimulus involved in visual perception (GO:0050908)3.27683201
51detection of light stimulus involved in sensory perception (GO:0050962)3.27683201
52pyrimidine nucleobase catabolic process (GO:0006208)3.25724943
53regulation of fibrinolysis (GO:0051917)3.25581656
54phospholipid efflux (GO:0033700)3.23426372
55DNA deamination (GO:0045006)3.15503782
56homocysteine metabolic process (GO:0050667)3.13327477
57NAD biosynthetic process (GO:0009435)3.12176410
58tyrosine metabolic process (GO:0006570)3.12036949
59indole-containing compound metabolic process (GO:0042430)3.11242773
60regulation of bile acid biosynthetic process (GO:0070857)3.11137801
61histone H3-K4 trimethylation (GO:0080182)3.09943895
62cilium or flagellum-dependent cell motility (GO:0001539)3.09829240
63gamma-aminobutyric acid transport (GO:0015812)3.08812067
64protein carboxylation (GO:0018214)3.08263130
65peptidyl-glutamic acid carboxylation (GO:0017187)3.08263130
66regulation of triglyceride catabolic process (GO:0010896)3.07868410
67mitochondrial respiratory chain complex I assembly (GO:0032981)3.07523399
68NADH dehydrogenase complex assembly (GO:0010257)3.07523399
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07523399
70plasma lipoprotein particle assembly (GO:0034377)3.07413847
71sulfur amino acid catabolic process (GO:0000098)3.07236926
72negative regulation of translation, ncRNA-mediated (GO:0040033)3.03714717
73regulation of translation, ncRNA-mediated (GO:0045974)3.03714717
74negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.03714717
75positive regulation of cellular amide metabolic process (GO:0034250)3.02402383
76plasma lipoprotein particle remodeling (GO:0034369)3.01822507
77protein-lipid complex remodeling (GO:0034368)3.01822507
78macromolecular complex remodeling (GO:0034367)3.01822507
79nephron epithelium morphogenesis (GO:0072088)3.00265200
80nephron tubule morphogenesis (GO:0072078)3.00265200
81cilium movement (GO:0003341)2.97731889
82cholesterol efflux (GO:0033344)2.94323795
83neuronal action potential (GO:0019228)2.92798663
84imidazole-containing compound metabolic process (GO:0052803)2.92182056
85regulation of telomere maintenance (GO:0032204)2.91912280
86protein complex biogenesis (GO:0070271)2.91909780
87alpha-amino acid catabolic process (GO:1901606)2.90961581
88nonmotile primary cilium assembly (GO:0035058)2.90854446
89bile acid and bile salt transport (GO:0015721)2.90310613
90opsonization (GO:0008228)2.89171259
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.87424565
92protein activation cascade (GO:0072376)2.86995614
93cellular glucuronidation (GO:0052695)2.85222280
94axoneme assembly (GO:0035082)2.84992934
95embryonic retina morphogenesis in camera-type eye (GO:0060059)2.84837681
96serine family amino acid catabolic process (GO:0009071)2.84653025
97sulfation (GO:0051923)2.84236097
98blood coagulation, intrinsic pathway (GO:0007597)2.84156613
99primary amino compound metabolic process (GO:1901160)2.84043338
100nucleobase catabolic process (GO:0046113)2.82032524
101negative regulation of complement activation (GO:0045916)2.81812397
102rRNA catabolic process (GO:0016075)2.81716835
103fatty acid beta-oxidation (GO:0006635)2.81259328
104regulation of glucokinase activity (GO:0033131)2.81230573
105regulation of hexokinase activity (GO:1903299)2.81230573
106coenzyme catabolic process (GO:0009109)2.80044811
107platelet dense granule organization (GO:0060155)2.79650219
108preassembly of GPI anchor in ER membrane (GO:0016254)2.78988884
109negative regulation of fibrinolysis (GO:0051918)2.78964447
110short-chain fatty acid metabolic process (GO:0046459)2.78458259
111reciprocal meiotic recombination (GO:0007131)2.78204862
112reciprocal DNA recombination (GO:0035825)2.78204862
113complement activation, classical pathway (GO:0006958)2.77750446
114behavioral response to ethanol (GO:0048149)2.77651695
115low-density lipoprotein particle remodeling (GO:0034374)2.77471332
116piRNA metabolic process (GO:0034587)2.77441417
117complement activation (GO:0006956)2.77336983
118carnitine metabolic process (GO:0009437)2.76840588
119dicarboxylic acid biosynthetic process (GO:0043650)2.75656418
120plasma lipoprotein particle organization (GO:0071827)2.75532559
121positive regulation of respiratory burst (GO:0060267)2.74439781
122regulation of phospholipase A2 activity (GO:0032429)2.74379998
123reflex (GO:0060004)2.74227964
124cornea development in camera-type eye (GO:0061303)2.73538352
125regulation of action potential (GO:0098900)2.73348445
126cilium morphogenesis (GO:0060271)2.73332527
127mitochondrial respiratory chain complex assembly (GO:0033108)2.73054381
128protein-lipid complex assembly (GO:0065005)2.72975810
129regulation of posttranscriptional gene silencing (GO:0060147)2.70697739
130regulation of gene silencing by miRNA (GO:0060964)2.70697739
131regulation of gene silencing by RNA (GO:0060966)2.70697739
132regulation of nuclear cell cycle DNA replication (GO:0033262)2.70577451
133cilium organization (GO:0044782)2.68559233
134protein polyglutamylation (GO:0018095)2.67863255
135valine metabolic process (GO:0006573)2.67566381
136fatty acid oxidation (GO:0019395)2.66593919
137nicotinamide nucleotide biosynthetic process (GO:0019359)2.66305456
138pyridine nucleotide biosynthetic process (GO:0019363)2.66305456
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.65682411
140lipid oxidation (GO:0034440)2.63949625
141plasma lipoprotein particle clearance (GO:0034381)2.63805604
142respiratory chain complex IV assembly (GO:0008535)2.63432267
143nucleotide transmembrane transport (GO:1901679)2.63326894
144protein K11-linked deubiquitination (GO:0035871)2.62994263
145inner ear receptor stereocilium organization (GO:0060122)2.62945526
146regulation of cholesterol esterification (GO:0010872)2.62589880
147serotonin metabolic process (GO:0042428)2.62535496
148urate metabolic process (GO:0046415)2.61435105
149cilium assembly (GO:0042384)2.60767933
150regulation of mesoderm development (GO:2000380)2.59044069
151ubiquinone biosynthetic process (GO:0006744)2.59041807
152fatty acid catabolic process (GO:0009062)2.58555846
153regulation of rhodopsin mediated signaling pathway (GO:0022400)2.58491187
154negative regulation of cytosolic calcium ion concentration (GO:0051481)2.58140422
155linoleic acid metabolic process (GO:0043651)2.58019148
156regulation of hippo signaling (GO:0035330)2.57650755
157protein-lipid complex subunit organization (GO:0071825)2.57593137
158replication fork processing (GO:0031297)2.55317340
159purine nucleotide transport (GO:0015865)2.54854024
160somite rostral/caudal axis specification (GO:0032525)2.54603470
161androgen biosynthetic process (GO:0006702)2.54485599
162cysteine metabolic process (GO:0006534)2.53934807
163benzene-containing compound metabolic process (GO:0042537)2.53643842
164negative regulation of transcription regulatory region DNA binding (GO:2000678)2.53641835
165cellular amino acid catabolic process (GO:0009063)2.53551644
166negative regulation of DNA-dependent DNA replication (GO:2000104)2.51878011
167monocarboxylic acid catabolic process (GO:0072329)2.51636592
168cAMP catabolic process (GO:0006198)2.51410265
169positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.50998942
170purine ribonucleotide transport (GO:0015868)2.50306353
171ethanol oxidation (GO:0006069)2.50106143
172rhodopsin mediated signaling pathway (GO:0016056)2.49394258
173negative regulation of mast cell activation (GO:0033004)2.49244332
174alanine transport (GO:0032328)2.48320082
175auditory receptor cell stereocilium organization (GO:0060088)2.47523797
176ubiquinone metabolic process (GO:0006743)2.47355879
177spinal cord motor neuron differentiation (GO:0021522)2.46973066
178proline transport (GO:0015824)2.46830070
179protein-cofactor linkage (GO:0018065)2.46569093
180recombinational repair (GO:0000725)2.45626668
181hindbrain development (GO:0030902)2.45193854
182androgen metabolic process (GO:0008209)2.45159557
183protein localization to cilium (GO:0061512)2.44575695
184lipoprotein metabolic process (GO:0042157)2.44177209
185regulation of humoral immune response (GO:0002920)2.44138135
186positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.44073820
187positive regulation of oligodendrocyte differentiation (GO:0048714)2.42556697
188membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.42482411
189double-strand break repair via homologous recombination (GO:0000724)2.41918675
190dopamine transport (GO:0015872)2.41575230
191negative regulation of synaptic transmission, GABAergic (GO:0032229)2.40918856

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.18382894
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.02627126
3EGR1_23403033_ChIP-Seq_LIVER_Mouse3.83777953
4EZH2_22144423_ChIP-Seq_EOC_Human3.80843251
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.28855474
6VDR_22108803_ChIP-Seq_LS180_Human3.28827940
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.84362424
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.76433470
9GBX2_23144817_ChIP-Seq_PC3_Human2.61450942
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.53181637
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32751572
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.23742841
13IGF1R_20145208_ChIP-Seq_DFB_Human2.17760642
14GATA1_22025678_ChIP-Seq_K562_Human2.12754758
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.08758851
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.03859170
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02999978
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95492255
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.90951086
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86942238
21TAF15_26573619_Chip-Seq_HEK293_Human1.84451127
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84426848
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83346026
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.83008752
25ER_23166858_ChIP-Seq_MCF-7_Human1.82918596
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81282438
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.79845066
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79499322
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78128416
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77644716
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.75825082
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75360797
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71908037
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70889867
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69328821
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68813016
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67725894
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65456789
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.64331735
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.62389229
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.60559684
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59307519
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58984784
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.58708436
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.57874371
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56974966
47SCL_19346495_ChIP-Seq_HPC-7_Human1.51072016
48* AR_25329375_ChIP-Seq_VCAP_Human1.48512597
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47954796
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47912577
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47912577
52TP53_22573176_ChIP-Seq_HFKS_Human1.47447987
53REST_21632747_ChIP-Seq_MESCs_Mouse1.47381700
54CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.47052164
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.46420770
56CBP_20019798_ChIP-Seq_JUKART_Human1.45253186
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45253186
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44857974
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42810279
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42180468
61P53_22387025_ChIP-Seq_ESCs_Mouse1.40250431
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39848495
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37730629
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.37239962
65MYC_18940864_ChIP-ChIP_HL60_Human1.37130401
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.36930935
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36096356
68RNF2_27304074_Chip-Seq_NSC_Mouse1.35575804
69* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34909701
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.33146694
71TCF4_22108803_ChIP-Seq_LS180_Human1.31831595
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.31596354
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31526238
74OCT4_21477851_ChIP-Seq_ESCs_Mouse1.31379843
75* IRF1_19129219_ChIP-ChIP_H3396_Human1.31210787
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31091162
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30756936
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29941651
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.29764760
80GABP_17652178_ChIP-ChIP_JURKAT_Human1.28956570
81P300_19829295_ChIP-Seq_ESCs_Human1.28328917
82RUNX1_27457419_Chip-Seq_LIVER_Mouse1.27856753
83SOX2_19829295_ChIP-Seq_ESCs_Human1.26710622
84NANOG_19829295_ChIP-Seq_ESCs_Human1.26710622
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.26685474
86RUNX2_22187159_ChIP-Seq_PCA_Human1.26652967
87EST1_17652178_ChIP-ChIP_JURKAT_Human1.26314134
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.25733807
89FOXA1_25329375_ChIP-Seq_VCAP_Human1.25728847
90FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25728847
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25433976
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.24549620
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.24021622
94P300_18555785_Chip-Seq_ESCs_Mouse1.23976848
95STAT3_18555785_Chip-Seq_ESCs_Mouse1.23834215
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22349535
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.19956008
98NMYC_18555785_Chip-Seq_ESCs_Mouse1.19936736
99SOX2_18555785_Chip-Seq_ESCs_Mouse1.18968506
100* FOXA2_19822575_ChIP-Seq_HepG2_Human1.18928208
101HTT_18923047_ChIP-ChIP_STHdh_Human1.18337974
102TP53_16413492_ChIP-PET_HCT116_Human1.17243699
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16226993
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15041160
105PU1_27457419_Chip-Seq_LIVER_Mouse1.14674166
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14604184
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14556750
108GATA3_21878914_ChIP-Seq_MCF-7_Human1.14142601
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.13729357
110AR_21572438_ChIP-Seq_LNCaP_Human1.11857864
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11564297
112ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11348235
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10932042
114* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10648343
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.09847151
116ZFX_18555785_Chip-Seq_ESCs_Mouse1.09404409
117STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09322615
118ESRRB_18555785_Chip-Seq_ESCs_Mouse1.08953851
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.08778776
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08498106
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.08486990
122SMAD4_21799915_ChIP-Seq_A2780_Human1.07612915
123STAT3_23295773_ChIP-Seq_U87_Human1.07135245
124SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06958001
125AR_20517297_ChIP-Seq_VCAP_Human1.06116793
126* FUS_26573619_Chip-Seq_HEK293_Human1.04820808
127KLF4_18555785_Chip-Seq_ESCs_Mouse1.04306695
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03388070
129CBX2_27304074_Chip-Seq_ESCs_Mouse1.03180781
130BCAT_22108803_ChIP-Seq_LS180_Human1.03177876
131EZH2_27304074_Chip-Seq_ESCs_Mouse1.03014673
132CTCF_18555785_Chip-Seq_ESCs_Mouse1.02952423
133NCOR_22424771_ChIP-Seq_293T_Human1.02089863
134SALL1_21062744_ChIP-ChIP_HESCs_Human1.02014301
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01991355
136LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01561697
137KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00303147
138HOXB7_26014856_ChIP-Seq_BT474_Human1.00106290
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99984746
140SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99422450
141KDM2B_26808549_Chip-Seq_REH_Human0.98303423
142IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97967596
143ELK1_19687146_ChIP-ChIP_HELA_Human0.97078658
144NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96964156
145NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96964156
146TAL1_26923725_Chip-Seq_HPCs_Mouse0.96505277
147VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96286182
148FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95800065
149TCF4_23295773_ChIP-Seq_U87_Human0.95248964
150SOX2_21211035_ChIP-Seq_LN229_Gbm0.95246738
151BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95052076
152REST_18959480_ChIP-ChIP_MESCs_Mouse0.94877332
153POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94578382
154CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94380191
155RUNX_20019798_ChIP-Seq_JUKART_Human0.94313480
156* EWS_26573619_Chip-Seq_HEK293_Human0.94243511
157EED_16625203_ChIP-ChIP_MESCs_Mouse0.94228677
158UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93689902
159JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93568184
160JUN_21703547_ChIP-Seq_K562_Human0.92677641
161CDX2_22108803_ChIP-Seq_LS180_Human0.92384426

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.75641912
2MP0002139_abnormal_hepatobiliary_system5.66724097
3MP0005365_abnormal_bile_salt5.20992318
4MP0005085_abnormal_gallbladder_physiolo4.56986241
5MP0003252_abnormal_bile_duct3.69565134
6MP0000566_synostosis3.23220074
7MP0008875_abnormal_xenobiotic_pharmacok2.93888960
8MP0008877_abnormal_DNA_methylation2.80010279
9MP0005451_abnormal_body_composition2.69306849
10MP0009697_abnormal_copulation2.42039802
11MP0004381_abnormal_hair_follicle2.42025850
12MP0010329_abnormal_lipoprotein_level2.41007789
13MP0005551_abnormal_eye_electrophysiolog2.38296405
14MP0005670_abnormal_white_adipose2.33385157
15MP0003195_calcinosis2.33056977
16MP0000569_abnormal_digit_pigmentation2.23916487
17MP0001666_abnormal_nutrient_absorption2.15654913
18MP0003787_abnormal_imprinting2.15334523
19MP0003868_abnormal_feces_composition2.14585279
20MP0001968_abnormal_touch/_nociception2.12007276
21MP0004133_heterotaxia2.04766151
22MP0009745_abnormal_behavioral_response2.00614672
23MP0009046_muscle_twitch1.95441110
24MP0010368_abnormal_lymphatic_system1.94255612
25MP0002138_abnormal_hepatobiliary_system1.91166877
26MP0002653_abnormal_ependyma_morphology1.90985334
27MP0004142_abnormal_muscle_tone1.87716355
28MP0004043_abnormal_pH_regulation1.84574726
29MP0008872_abnormal_physiological_respon1.84205336
30MP0003880_abnormal_central_pattern1.82201805
31MP0006072_abnormal_retinal_apoptosis1.81166174
32MP0002254_reproductive_system_inflammat1.79303429
33MP0003646_muscle_fatigue1.78085133
34MP0002837_dystrophic_cardiac_calcinosis1.77141151
35MP0005408_hypopigmentation1.76334202
36MP0001485_abnormal_pinna_reflex1.73342081
37MP0004885_abnormal_endolymph1.73017542
38MP0005647_abnormal_sex_gland1.70638478
39MP0002736_abnormal_nociception_after1.70075236
40MP0005253_abnormal_eye_physiology1.68965365
41MP0002272_abnormal_nervous_system1.65281750
42MP0001986_abnormal_taste_sensitivity1.59636468
43MP0003890_abnormal_embryonic-extraembry1.58503235
44MP0002928_abnormal_bile_duct1.57935013
45MP0006276_abnormal_autonomic_nervous1.56922017
46MP0002118_abnormal_lipid_homeostasis1.56568739
47MP0000631_abnormal_neuroendocrine_gland1.55172773
48MP0003950_abnormal_plasma_membrane1.51328642
49MP0000609_abnormal_liver_physiology1.49344106
50MP0001486_abnormal_startle_reflex1.46822147
51MP0009764_decreased_sensitivity_to1.46205705
52MP0002876_abnormal_thyroid_physiology1.45198852
53MP0002938_white_spotting1.44891746
54MP0002572_abnormal_emotion/affect_behav1.44883638
55MP0001501_abnormal_sleep_pattern1.43906148
56MP0005332_abnormal_amino_acid1.43850503
57MP0002557_abnormal_social/conspecific_i1.42499816
58MP0004019_abnormal_vitamin_homeostasis1.41208527
59MP0004145_abnormal_muscle_electrophysio1.38709132
60MP0002064_seizures1.37174739
61MP0005409_darkened_coat_color1.36515045
62MP0000383_abnormal_hair_follicle1.33294528
63MP0002163_abnormal_gland_morphology1.28485631
64MP0000579_abnormal_nail_morphology1.28282747
65MP0001764_abnormal_homeostasis1.28018108
66MP0003136_yellow_coat_color1.27569082
67MP0005083_abnormal_biliary_tract1.27400478
68MP0004742_abnormal_vestibular_system1.26273938
69MP0005220_abnormal_exocrine_pancreas1.26218892
70MP0002067_abnormal_sensory_capabilities1.25112122
71MP0002160_abnormal_reproductive_system1.23591937
72MP0000427_abnormal_hair_cycle1.21858560
73MP0002735_abnormal_chemical_nociception1.19653540
74MP0000778_abnormal_nervous_system1.18740858
75MP0002733_abnormal_thermal_nociception1.18045785
76MP0001970_abnormal_pain_threshold1.17789946
77MP0001835_abnormal_antigen_presentation1.16211424
78MP0002063_abnormal_learning/memory/cond1.15487751
79MP0001529_abnormal_vocalization1.15203263
80MP0005195_abnormal_posterior_eye1.14833025
81MP0009763_increased_sensitivity_to1.14770905
82MP0003635_abnormal_synaptic_transmissio1.14344043
83MP0001984_abnormal_olfaction1.13925591
84MP0005387_immune_system_phenotype1.12957094
85MP0001790_abnormal_immune_system1.12957094
86MP0005389_reproductive_system_phenotype1.12505845
87MP0005386_behavior/neurological_phenoty1.11042422
88MP0004924_abnormal_behavior1.11042422
89MP0003878_abnormal_ear_physiology1.09173835
90MP0005377_hearing/vestibular/ear_phenot1.09173835
91MP0002971_abnormal_brown_adipose1.08438552
92MP0009384_cardiac_valve_regurgitation1.06968784
93MP0001346_abnormal_lacrimal_gland1.06770809
94MP0003119_abnormal_digestive_system1.06462622
95MP0000685_abnormal_immune_system1.05864210
96MP0003121_genomic_imprinting1.04623989
97MP0001919_abnormal_reproductive_system1.02284071
98MP0003283_abnormal_digestive_organ1.00965889
99MP0006292_abnormal_olfactory_placode1.00554923
100MP0005646_abnormal_pituitary_gland1.00338057
101MP0005075_abnormal_melanosome_morpholog0.99966668
102MP0001905_abnormal_dopamine_level0.97505164
103MP0002752_abnormal_somatic_nervous0.97478166
104MP0003191_abnormal_cellular_cholesterol0.97387966
105MP0003137_abnormal_impulse_conducting0.96409615
106MP0005334_abnormal_fat_pad0.95910899
107MP0003718_maternal_effect0.94672646
108MP0000026_abnormal_inner_ear0.93654034
109MP0005174_abnormal_tail_pigmentation0.91978005
110MP0003011_delayed_dark_adaptation0.91723640
111MP0002734_abnormal_mechanical_nocicepti0.91617196
112MP0001293_anophthalmia0.91286032
113MP0004215_abnormal_myocardial_fiber0.90449677
114MP0003122_maternal_imprinting0.90260011
115MP0009765_abnormal_xenobiotic_induced0.90158802
116MP0010386_abnormal_urinary_bladder0.89058526
117MP0001270_distended_abdomen0.88767510
118MP0008995_early_reproductive_senescence0.88392883
119MP0003937_abnormal_limbs/digits/tail_de0.88385869
120MP0008058_abnormal_DNA_repair0.88372915
121MP0008961_abnormal_basal_metabolism0.88246462
122MP0002234_abnormal_pharynx_morphology0.87516708
123MP0002095_abnormal_skin_pigmentation0.87264408
124MP0002184_abnormal_innervation0.86746475
125MP0001324_abnormal_eye_pigmentation0.85952762
126MP0003698_abnormal_male_reproductive0.85944941
127MP0005379_endocrine/exocrine_gland_phen0.85857786
128MP0005319_abnormal_enzyme/_coenzyme0.84165645
129MP0002751_abnormal_autonomic_nervous0.84160951
130MP0003806_abnormal_nucleotide_metabolis0.84146135
131MP0001879_abnormal_lymphatic_vessel0.83788123
132MP0000647_abnormal_sebaceous_gland0.83239185
133MP0000767_abnormal_smooth_muscle0.83123733
134MP0005410_abnormal_fertilization0.82492430
135MP0005187_abnormal_penis_morphology0.82204345
136MP0004147_increased_porphyrin_level0.82041294
137MP0005423_abnormal_somatic_nervous0.80975109
138MP0001502_abnormal_circadian_rhythm0.80405282
139MP0002229_neurodegeneration0.80047676
140MP0000230_abnormal_systemic_arterial0.79913480
141MP0005167_abnormal_blood-brain_barrier0.79788994
142MP0005084_abnormal_gallbladder_morpholo0.78881544
143MP0005584_abnormal_enzyme/coenzyme_acti0.78736903
144MP0002168_other_aberrant_phenotype0.74986547
145MP0005464_abnormal_platelet_physiology0.74898906
146MP0002419_abnormal_innate_immunity0.74277979
147MP0000015_abnormal_ear_pigmentation0.74135170
148MP0000372_irregular_coat_pigmentation0.74033736
149MP0003724_increased_susceptibility_to0.72197774
150MP0002277_abnormal_respiratory_mucosa0.72130473
151MP0008469_abnormal_protein_level0.70174034
152MP0010678_abnormal_skin_adnexa0.69534890
153MP0002396_abnormal_hematopoietic_system0.68752275
154MP0009840_abnormal_foam_cell0.68291311
155MP0001853_heart_inflammation0.68132350
156MP0002638_abnormal_pupillary_reflex0.68028276
157MP0005666_abnormal_adipose_tissue0.67285209
158MP0002098_abnormal_vibrissa_morphology0.66775676
159MP0003690_abnormal_glial_cell0.66549096
160MP0000613_abnormal_salivary_gland0.66405302
161MP0000538_abnormal_urinary_bladder0.66281443
162MP0003656_abnormal_erythrocyte_physiolo0.64404778
163MP0009785_altered_susceptibility_to0.64061748
164MP0005671_abnormal_response_to0.63329527
165MP0002009_preneoplasia0.62930172
166MP0009643_abnormal_urine_homeostasis0.62529941
167MP0004782_abnormal_surfactant_physiolog0.62328075
168MP0002249_abnormal_larynx_morphology0.61638775
169MP0001119_abnormal_female_reproductive0.61381645
170MP0002078_abnormal_glucose_homeostasis0.61347383
171MP0002102_abnormal_ear_morphology0.61094074
172MP0001800_abnormal_humoral_immune0.59663083
173MP0001188_hyperpigmentation0.59597339
174MP0009642_abnormal_blood_homeostasis0.59124884
175MP0000598_abnormal_liver_morphology0.58763334
176MP0005645_abnormal_hypothalamus_physiol0.56831585
177MP0003943_abnormal_hepatobiliary_system0.56793816
178MP0005025_abnormal_response_to0.53715894
179MP0000371_diluted_coat_color0.53226157

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)5.02796955
2Intrahepatic cholestasis (HP:0001406)4.94460293
3Pancreatic cysts (HP:0001737)4.69395445
4Conjugated hyperbilirubinemia (HP:0002908)4.62726734
5Molar tooth sign on MRI (HP:0002419)4.27464306
6Abnormality of midbrain morphology (HP:0002418)4.27464306
7Pancreatic fibrosis (HP:0100732)4.27329058
8True hermaphroditism (HP:0010459)4.06996338
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.96379981
10Deep venous thrombosis (HP:0002625)3.93155487
11Joint hemorrhage (HP:0005261)3.90841272
12Congenital stationary night blindness (HP:0007642)3.85789574
13Nephronophthisis (HP:0000090)3.85473782
14Renal cortical cysts (HP:0000803)3.71715047
15Complement deficiency (HP:0004431)3.62382113
16Hyperlipoproteinemia (HP:0010980)3.48223660
17Hyperventilation (HP:0002883)3.37585904
18Epidermoid cyst (HP:0200040)3.35889490
19Abnormal biliary tract physiology (HP:0012439)3.35335300
20Bile duct proliferation (HP:0001408)3.35335300
21Abnormality of the renal medulla (HP:0100957)3.35240413
22Abnormality of monocarboxylic acid metabolism (HP:0010996)3.26183540
23Type II lissencephaly (HP:0007260)3.25529789
24Xanthomatosis (HP:0000991)3.06624560
25Abnormality of the fingertips (HP:0001211)3.03108233
26Medial flaring of the eyebrow (HP:0010747)3.01484088
27Hypoglycemic coma (HP:0001325)3.00577201
28Tubular atrophy (HP:0000092)2.91362169
29Chronic hepatic failure (HP:0100626)2.89205284
30Inability to walk (HP:0002540)2.86381417
31Abnormality of methionine metabolism (HP:0010901)2.85786200
32Hyperglycinuria (HP:0003108)2.83169326
33Cystic liver disease (HP:0006706)2.81869814
34Congenital, generalized hypertrichosis (HP:0004540)2.79608577
35Gingival bleeding (HP:0000225)2.74872464
36Attenuation of retinal blood vessels (HP:0007843)2.72186931
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71304516
38Abnormality of alanine metabolism (HP:0010916)2.71304516
39Hyperalaninemia (HP:0003348)2.71304516
40Abnormality of the renal cortex (HP:0011035)2.70997204
41Abnormality of aspartate family amino acid metabolism (HP:0010899)2.69160139
42Hypercholesterolemia (HP:0003124)2.68977264
43Abnormality of the common coagulation pathway (HP:0010990)2.67389920
44Hypoglycemic seizures (HP:0002173)2.67356555
45Abnormality of the intrinsic pathway (HP:0010989)2.66687009
46Abolished electroretinogram (ERG) (HP:0000550)2.64817971
47Lip pit (HP:0100267)2.63107748
48Lissencephaly (HP:0001339)2.62693273
49Fat malabsorption (HP:0002630)2.62576911
50Ketosis (HP:0001946)2.60030891
51Large for gestational age (HP:0001520)2.59433274
52Progressive inability to walk (HP:0002505)2.57778574
53Birth length less than 3rd percentile (HP:0003561)2.57367085
54Fair hair (HP:0002286)2.53380316
55Abnormality of sulfur amino acid metabolism (HP:0004339)2.52142914
56Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51891183
57Hypoalphalipoproteinemia (HP:0003233)2.51589478
58Enlarged kidneys (HP:0000105)2.48566770
59Progressive cerebellar ataxia (HP:0002073)2.48332872
60Gait imbalance (HP:0002141)2.48310110
61Protruding tongue (HP:0010808)2.44856935
62Concave nail (HP:0001598)2.44722377
63Myocardial infarction (HP:0001658)2.43440480
64Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.42882649
65Sclerocornea (HP:0000647)2.42737382
66Hypobetalipoproteinemia (HP:0003563)2.39432083
67Abnormality of serine family amino acid metabolism (HP:0010894)2.38606850
68Abnormality of glycine metabolism (HP:0010895)2.38606850
69Polydipsia (HP:0001959)2.38188903
70Abnormal drinking behavior (HP:0030082)2.38188903
71Spontaneous abortion (HP:0005268)2.37257882
72Hyperglycinemia (HP:0002154)2.36370789
73Patellar aplasia (HP:0006443)2.36358307
74Pendular nystagmus (HP:0012043)2.36252466
75Congenital primary aphakia (HP:0007707)2.36152405
76Vascular calcification (HP:0004934)2.34702542
77Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.33087129
78Hyperbilirubinemia (HP:0002904)2.33020174
79Hypoplasia of the thymus (HP:0000778)2.32835789
80Genetic anticipation (HP:0003743)2.32459485
81Generalized aminoaciduria (HP:0002909)2.32150964
82Nephrogenic diabetes insipidus (HP:0009806)2.31917464
83Aplasia/Hypoplasia of the tibia (HP:0005772)2.31644180
84Cerebellar dysplasia (HP:0007033)2.31070947
85Mitral stenosis (HP:0001718)2.30448945
86Aplasia/Hypoplasia of the tongue (HP:0010295)2.29011602
87Symptomatic seizures (HP:0011145)2.27994655
88Furrowed tongue (HP:0000221)2.27346105
89Abnormality of fatty-acid metabolism (HP:0004359)2.26217506
90Congenital hepatic fibrosis (HP:0002612)2.25643985
91Gaze-evoked nystagmus (HP:0000640)2.25477605
92Hyperammonemia (HP:0001987)2.25050708
93Aplasia/Hypoplasia of the patella (HP:0006498)2.23420228
94Anencephaly (HP:0002323)2.21788281
95Neonatal hypoglycemia (HP:0001998)2.21327229
96Hypolipoproteinemia (HP:0010981)2.21149357
97Abnormal rod and cone electroretinograms (HP:0008323)2.20138651
98Chronic diarrhea (HP:0002028)2.19831200
99Dynein arm defect of respiratory motile cilia (HP:0012255)2.17434664
100Absent/shortened dynein arms (HP:0200106)2.17434664
101Hypothermia (HP:0002045)2.16088956
102Pigmentary retinal degeneration (HP:0001146)2.16023163
103Broad-based gait (HP:0002136)2.15838013
104Abnormality of complement system (HP:0005339)2.15312580
105Male pseudohermaphroditism (HP:0000037)2.11863541
106Keratoconus (HP:0000563)2.10383001
107Increased corneal curvature (HP:0100692)2.10383001
108Abnormality of incisor morphology (HP:0011063)2.08135197
109Decreased central vision (HP:0007663)2.07788077
110Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06953595
111Dicarboxylic aciduria (HP:0003215)2.06953595
112Recurrent gram-negative bacterial infections (HP:0005420)2.06687182
113Depressed nasal tip (HP:0000437)2.05960030
114Chorioretinal atrophy (HP:0000533)2.05468553
115Abnormality of the pons (HP:0007361)2.05342635
116Elevated hepatic transaminases (HP:0002910)2.05272809
117Abnormal respiratory epithelium morphology (HP:0012253)2.05209651
118Abnormal respiratory motile cilium morphology (HP:0005938)2.05209651
119Cardiovascular calcification (HP:0011915)2.05140745
120Decreased circulating renin level (HP:0003351)2.04826898
121Genital tract atresia (HP:0001827)2.02859552
122Ectropion (HP:0000656)2.01112823
123Bilateral microphthalmos (HP:0007633)2.00664415
124Portal hypertension (HP:0001409)2.00277223
125Clumsiness (HP:0002312)1.99971012
126Retinal dysplasia (HP:0007973)1.98927157
127Abnormality of the hepatic vasculature (HP:0006707)1.98482776
128Abnormal ciliary motility (HP:0012262)1.97536043
129Vaginal atresia (HP:0000148)1.97268122
130Osteomalacia (HP:0002749)1.96099481
131Polyuria (HP:0000103)1.93039770
132Abnormality of the columella (HP:0009929)1.92528609
133Generalized hypopigmentation of hair (HP:0011358)1.92402723
134Colon cancer (HP:0003003)1.92200451
135Steatorrhea (HP:0002570)1.91510804
136Bony spicule pigmentary retinopathy (HP:0007737)1.91226606
137Hemorrhage of the eye (HP:0011885)1.90353238
138Hemiparesis (HP:0001269)1.89958500
139Hypoplasia of the pons (HP:0012110)1.89423293
140Glomerulonephritis (HP:0000099)1.88684481
141Postaxial foot polydactyly (HP:0001830)1.88174919
142Febrile seizures (HP:0002373)1.88170579
143Pachygyria (HP:0001302)1.86573914
144Increased CSF lactate (HP:0002490)1.85149657
145Mitochondrial inheritance (HP:0001427)1.83738346
146Delayed CNS myelination (HP:0002188)1.83660972
147Poor coordination (HP:0002370)1.83216096
148Metabolic acidosis (HP:0001942)1.82953445
149Acanthocytosis (HP:0001927)1.82614947
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82149292
151Severe muscular hypotonia (HP:0006829)1.82137155
152Aplasia/Hypoplasia of the fovea (HP:0008060)1.81255037
153Hypoplasia of the fovea (HP:0007750)1.81255037
154Cupped ear (HP:0000378)1.80306988
155Acute necrotizing encephalopathy (HP:0006965)1.80249842
156Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80240719
157Abnormality of serum amino acid levels (HP:0003112)1.79817099
158Hypophosphatemic rickets (HP:0004912)1.79812341
159Methylmalonic acidemia (HP:0002912)1.79370332
160Abnormality of pyrimidine metabolism (HP:0004353)1.78416863
161Midline defect of the nose (HP:0004122)1.78177266
162Hypochromic microcytic anemia (HP:0004840)1.77763074
163Intestinal atresia (HP:0011100)1.77761646
1643-Methylglutaconic aciduria (HP:0003535)1.77087453
165Ketoacidosis (HP:0001993)1.77061398
166Thrombophlebitis (HP:0004418)1.76966712
167Tubulointerstitial nephritis (HP:0001970)1.76847972
168Dandy-Walker malformation (HP:0001305)1.75774956
169Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75379561
170Occipital encephalocele (HP:0002085)1.74621997
171Hepatocellular carcinoma (HP:0001402)1.74027975
172Systemic lupus erythematosus (HP:0002725)1.73890944
173Aplasia/Hypoplasia of the uvula (HP:0010293)1.73760629
174Esophageal varix (HP:0002040)1.72626814
175Acute encephalopathy (HP:0006846)1.72186449
176Hyperglycemia (HP:0003074)1.71231902
177Tachypnea (HP:0002789)1.71080340
178Focal motor seizures (HP:0011153)1.70717031
179Optic nerve hypoplasia (HP:0000609)1.70598882
180Thyroid-stimulating hormone excess (HP:0002925)1.67986410
181Epistaxis (HP:0000421)1.67441392
182Acute myeloid leukemia (HP:0004808)1.66604844
183Neoplasm of the tracheobronchial system (HP:0100552)1.65583277
184Alveolar cell carcinoma (HP:0006519)1.65153396
185Abnormality of nucleobase metabolism (HP:0010932)1.64982143
186Renal tubular acidosis (HP:0001947)1.64423127
187Hyperinsulinemic hypoglycemia (HP:0000825)1.63220068
188Blue irides (HP:0000635)1.62825426
189Agammaglobulinemia (HP:0004432)1.62445192
190Abnormality of the axillary hair (HP:0100134)1.62415065
191Abnormality of secondary sexual hair (HP:0009888)1.62415065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.02157051
2LATS13.69717691
3INSRR3.23889563
4ACVR1B2.81299032
5NUAK12.64075396
6WNK32.48011870
7WNK42.39452630
8MKNK22.37385438
9TAOK32.32852030
10MAP4K22.26438626
11MAP3K42.15263058
12TLK12.13581719
13PNCK2.10046488
14SIK11.91747686
15MAP3K141.87007073
16PINK11.86742464
17IRAK31.84088388
18CAMK1D1.78603544
19MAP3K61.70280857
20BRD41.64940199
21IRAK41.63630573
22PRKAA21.62940720
23OXSR11.62589903
24CAMK1G1.62034902
25STK38L1.60094175
26STK391.57370711
27YES11.57094773
28SGK21.53888879
29MARK11.52645181
30MKNK11.49525945
31MUSK1.48433233
32EIF2AK21.46304768
33IKBKE1.46138449
34TGFBR11.45368379
35ZAK1.43699454
36ERBB41.40173108
37NTRK31.34566222
38CAMKK21.34559489
39DAPK21.28276771
40TRIM281.27902248
41MAP3K131.27286617
42DYRK21.26952791
43CDK31.25882176
44TEC1.24232451
45TGFBR21.22600646
46ADRBK11.19934918
47PIK3CG1.18212060
48CASK1.17756866
49JAK31.17626540
50TIE11.14327773
51PIK3CA1.13372892
52PAK31.10007583
53TYK21.09813632
54JAK11.08399084
55VRK11.07804704
56KIT1.04658725
57MAP2K61.04355083
58NLK1.04197469
59BMPR1B1.03884148
60TXK1.03482373
61MAPK111.02651700
62WEE11.00796584
63SRPK11.00104904
64PRKCG0.98535958
65CDK90.98364872
66MAPK130.95020768
67PKN10.93636384
68MAP2K70.93355115
69SGK30.93007244
70BRSK20.92945202
71TRPM70.92464258
72BTK0.91926048
73TAF10.91602027
74FGFR40.90416520
75SGK4940.90332361
76SGK2230.90332361
77STK30.87010401
78BCKDK0.86741718
79MAP3K70.86156244
80CLK10.85948422
81GRK10.85417820
82MAPKAPK50.84702533
83OBSCN0.83944420
84IKBKB0.83689298
85PRKCE0.83129344
86CHUK0.82869174
87ERN10.82695849
88MAP2K30.81037419
89MAPKAPK30.80844967
90MAPK70.80266150
91FGFR20.80133975
92NEK60.72869852
93CSNK1G20.72332308
94PRKAA10.71673309
95CSNK1G10.71399652
96PLK20.71347856
97TSSK60.70122380
98BCR0.68444114
99NME10.67590790
100PHKG10.67356562
101PHKG20.67356562
102MAPK120.65687033
103PLK30.65537159
104ITK0.65327155
105FLT30.64451647
106VRK20.64107567
107STK40.60771325
108ABL10.60737480
109PTK2B0.59064422
110CSNK1G30.58538437
111NTRK20.58531019
112STK160.57879993
113CSNK1A1L0.57116514
114ERBB20.56977099
115SGK10.56672476
116MAP2K40.56367499
117MAPK150.55663552
118PLK40.54645467
119FRK0.54327652
120FGFR30.53891682
121CAMK40.53715430
122STK110.53704757
123TBK10.53329457
124PRKCQ0.52978005
125EPHA30.51586106
126CAMK2A0.51397319
127SIK30.51335784
128NEK90.51051233
129NEK20.49911738
130ADRBK20.49678326
131RPS6KA50.49184106
132IGF1R0.48346386
133ERBB30.47847585
134CDK60.47440255
135CAMK10.45148671
136CSF1R0.44971794
137DMPK0.44605680
138LYN0.44536317
139CDK190.43745359
140IRAK20.43404795
141SIK20.43127614
142PTK60.42664899
143HCK0.41381493
144JAK20.41150385
145PRKACA0.40626827
146CDK80.40129760
147DYRK1A0.39526023
148PASK0.38314692
149TYRO30.38011227
150PRKG10.37181444
151CSNK1A10.36942089
152CHEK20.36933887
153EPHA40.34855396
154IRAK10.32973181
155PLK10.32707871
156MAP2K10.31626187
157DYRK30.31518758
158CSNK1D0.31124055

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.92165378
2Phototransduction_Homo sapiens_hsa047442.83101640
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.71786560
4Tryptophan metabolism_Homo sapiens_hsa003802.67874187
5Complement and coagulation cascades_Homo sapiens_hsa046102.62032028
6Fatty acid degradation_Homo sapiens_hsa000712.61311110
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45305941
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44046822
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.33212330
10Nicotine addiction_Homo sapiens_hsa050332.26010172
11Nitrogen metabolism_Homo sapiens_hsa009102.23681485
12Peroxisome_Homo sapiens_hsa041462.22828199
13Oxidative phosphorylation_Homo sapiens_hsa001902.20383527
14Lysine degradation_Homo sapiens_hsa003102.11001828
15Propanoate metabolism_Homo sapiens_hsa006402.10657397
16beta-Alanine metabolism_Homo sapiens_hsa004102.06255771
17Arginine biosynthesis_Homo sapiens_hsa002202.03685643
18Staphylococcus aureus infection_Homo sapiens_hsa051502.02678083
19ABC transporters_Homo sapiens_hsa020101.98501160
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96542759
21Retinol metabolism_Homo sapiens_hsa008301.88202699
22Fatty acid elongation_Homo sapiens_hsa000621.87131528
23Fatty acid metabolism_Homo sapiens_hsa012121.86780054
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86439027
25Homologous recombination_Homo sapiens_hsa034401.85758925
26Histidine metabolism_Homo sapiens_hsa003401.84762278
27Caffeine metabolism_Homo sapiens_hsa002321.82141702
28Protein export_Homo sapiens_hsa030601.76205377
29PPAR signaling pathway_Homo sapiens_hsa033201.74002379
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.73498871
31Fanconi anemia pathway_Homo sapiens_hsa034601.73184559
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.73113733
33Butanoate metabolism_Homo sapiens_hsa006501.70073977
34Parkinsons disease_Homo sapiens_hsa050121.67037882
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66394307
36RNA polymerase_Homo sapiens_hsa030201.62666413
37Chemical carcinogenesis_Homo sapiens_hsa052041.59337547
38Basal transcription factors_Homo sapiens_hsa030221.57219111
39Olfactory transduction_Homo sapiens_hsa047401.53746815
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53452405
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.49610803
42Taste transduction_Homo sapiens_hsa047421.42690058
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38937962
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36669285
45Steroid biosynthesis_Homo sapiens_hsa001001.34686505
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.33483682
47Morphine addiction_Homo sapiens_hsa050321.31838868
48Cardiac muscle contraction_Homo sapiens_hsa042601.22659466
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22628870
50Huntingtons disease_Homo sapiens_hsa050161.19869818
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.18839802
52Starch and sucrose metabolism_Homo sapiens_hsa005001.18523925
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16980838
54Vitamin digestion and absorption_Homo sapiens_hsa049771.15651397
55Alzheimers disease_Homo sapiens_hsa050101.12502122
56Glutamatergic synapse_Homo sapiens_hsa047241.09869479
57Selenocompound metabolism_Homo sapiens_hsa004501.08720045
58Sulfur metabolism_Homo sapiens_hsa009201.07835306
59RNA degradation_Homo sapiens_hsa030181.05324644
60Circadian entrainment_Homo sapiens_hsa047131.05214958
61Serotonergic synapse_Homo sapiens_hsa047261.05171295
62Tyrosine metabolism_Homo sapiens_hsa003501.03224373
63One carbon pool by folate_Homo sapiens_hsa006701.03066645
64GABAergic synapse_Homo sapiens_hsa047271.01781715
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00826035
66Bile secretion_Homo sapiens_hsa049760.99447041
67Insulin secretion_Homo sapiens_hsa049110.98664027
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98506436
69Ovarian steroidogenesis_Homo sapiens_hsa049130.96964478
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94907927
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.92345375
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91479605
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90970673
74Circadian rhythm_Homo sapiens_hsa047100.90233105
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88600498
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88451222
77Fatty acid biosynthesis_Homo sapiens_hsa000610.82474112
78Arginine and proline metabolism_Homo sapiens_hsa003300.81234443
79Fat digestion and absorption_Homo sapiens_hsa049750.77890659
80Cocaine addiction_Homo sapiens_hsa050300.75250619
81Phenylalanine metabolism_Homo sapiens_hsa003600.74744549
82Glycerolipid metabolism_Homo sapiens_hsa005610.73173309
83Purine metabolism_Homo sapiens_hsa002300.72254623
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71070071
85Collecting duct acid secretion_Homo sapiens_hsa049660.70861052
86Calcium signaling pathway_Homo sapiens_hsa040200.67991568
87Salivary secretion_Homo sapiens_hsa049700.65532525
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64468675
89Sulfur relay system_Homo sapiens_hsa041220.64142007
90Dopaminergic synapse_Homo sapiens_hsa047280.63702625
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63204226
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.62775551
93Insulin resistance_Homo sapiens_hsa049310.62480289
94Ribosome_Homo sapiens_hsa030100.58008072
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56083735
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56001698
97Hedgehog signaling pathway_Homo sapiens_hsa043400.55194047
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55060903
99Autoimmune thyroid disease_Homo sapiens_hsa053200.54523389
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53695541
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.52743860
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51873935
103Amphetamine addiction_Homo sapiens_hsa050310.50298131
104Dorso-ventral axis formation_Homo sapiens_hsa043200.49953228
105Vitamin B6 metabolism_Homo sapiens_hsa007500.49472819
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49229090
107Primary immunodeficiency_Homo sapiens_hsa053400.48899289
108Long-term depression_Homo sapiens_hsa047300.48632899
109Non-homologous end-joining_Homo sapiens_hsa034500.48619319
110Herpes simplex infection_Homo sapiens_hsa051680.48491262
111Ether lipid metabolism_Homo sapiens_hsa005650.47286838
112Basal cell carcinoma_Homo sapiens_hsa052170.46775658
113Measles_Homo sapiens_hsa051620.45040281
114Other glycan degradation_Homo sapiens_hsa005110.42933576
115Sphingolipid metabolism_Homo sapiens_hsa006000.41447206
116Type I diabetes mellitus_Homo sapiens_hsa049400.40779054
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.40715615
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40395735
119Hematopoietic cell lineage_Homo sapiens_hsa046400.40165211
120Pyrimidine metabolism_Homo sapiens_hsa002400.38944996
121Asthma_Homo sapiens_hsa053100.38398075
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38394018
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.35349455
124Folate biosynthesis_Homo sapiens_hsa007900.35292498
125Gastric acid secretion_Homo sapiens_hsa049710.34444158
126Mineral absorption_Homo sapiens_hsa049780.34392087
127Cholinergic synapse_Homo sapiens_hsa047250.34265030
128Linoleic acid metabolism_Homo sapiens_hsa005910.34237898
129Oxytocin signaling pathway_Homo sapiens_hsa049210.33923949
130Pyruvate metabolism_Homo sapiens_hsa006200.31748701
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30548182
132Arachidonic acid metabolism_Homo sapiens_hsa005900.30288298
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.28846923
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26953543
135Hepatitis C_Homo sapiens_hsa051600.26846714
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26683028
137TNF signaling pathway_Homo sapiens_hsa046680.25816847
138Influenza A_Homo sapiens_hsa051640.25760308
139Metabolic pathways_Homo sapiens_hsa011000.25558907
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.24403581
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22444951
142Cysteine and methionine metabolism_Homo sapiens_hsa002700.21917416
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.20670512
144Leishmaniasis_Homo sapiens_hsa051400.19174876
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19132693
146Regulation of autophagy_Homo sapiens_hsa041400.18405180
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16281860
148Small cell lung cancer_Homo sapiens_hsa052220.16118362
149Osteoclast differentiation_Homo sapiens_hsa043800.15327083
150Notch signaling pathway_Homo sapiens_hsa043300.13112159
151Malaria_Homo sapiens_hsa051440.13037455

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