ZKSCAN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.54839092
2postsynaptic membrane organization (GO:0001941)4.85780931
3locomotory exploration behavior (GO:0035641)4.66462634
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.61465743
5neuron cell-cell adhesion (GO:0007158)4.27359787
6presynaptic membrane assembly (GO:0097105)4.26762329
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.09430895
8regulation of synaptic vesicle exocytosis (GO:2000300)4.05659858
9vocalization behavior (GO:0071625)3.98873180
10synaptic vesicle exocytosis (GO:0016079)3.97842907
11base-excision repair, AP site formation (GO:0006285)3.84966955
12neurotransmitter-gated ion channel clustering (GO:0072578)3.82042560
13cellular response to interferon-beta (GO:0035458)3.79511345
14glutamate secretion (GO:0014047)3.78673349
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.76913742
16protein localization to synapse (GO:0035418)3.74896441
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.72230583
18tRNA methylation (GO:0030488)3.70133515
19presynaptic membrane organization (GO:0097090)3.68951072
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.67286882
21regulation of glutamate receptor signaling pathway (GO:1900449)3.63478446
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.61055162
23synaptic vesicle maturation (GO:0016188)3.59922961
24DNA double-strand break processing (GO:0000729)3.59405617
25exploration behavior (GO:0035640)3.55289616
26cerebellar granule cell differentiation (GO:0021707)3.52586119
27synaptic transmission, glutamatergic (GO:0035249)3.50367588
28positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.49445486
29DNA strand elongation (GO:0022616)3.48267047
30pyrimidine nucleobase catabolic process (GO:0006208)3.45667566
31DNA strand elongation involved in DNA replication (GO:0006271)3.44188687
32lipopolysaccharide biosynthetic process (GO:0009103)3.36914601
33positive regulation of synaptic transmission, GABAergic (GO:0032230)3.34633624
34regulation of synaptic vesicle transport (GO:1902803)3.34299054
35proteasome assembly (GO:0043248)3.33843993
36negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.32841144
37IMP biosynthetic process (GO:0006188)3.32599485
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30937633
39ionotropic glutamate receptor signaling pathway (GO:0035235)3.29450090
40regulation of chromatin binding (GO:0035561)3.28447745
41glutamate receptor signaling pathway (GO:0007215)3.27815164
42regulation of vesicle fusion (GO:0031338)3.22466295
43neurotransmitter secretion (GO:0007269)3.21877466
44pyrimidine nucleotide catabolic process (GO:0006244)3.21874379
45amino sugar catabolic process (GO:0046348)3.21160815
46transmission of nerve impulse (GO:0019226)3.21142397
47snRNA processing (GO:0016180)3.19366033
48spliceosomal tri-snRNP complex assembly (GO:0000244)3.17615097
49protein localization to cilium (GO:0061512)3.17182446
50regulation of translation in response to stress (GO:0043555)3.15460551
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.14040188
52pentose metabolic process (GO:0019321)3.12726407
53snRNA metabolic process (GO:0016073)3.12381764
54neuronal action potential propagation (GO:0019227)3.11302876
55ribosome assembly (GO:0042255)3.10258882
56neuron-neuron synaptic transmission (GO:0007270)3.09114602
57dosage compensation (GO:0007549)3.07335833
58regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05888358
59positive regulation of B cell differentiation (GO:0045579)3.01305404
60behavioral response to cocaine (GO:0048148)3.01140651
61regulation of mast cell degranulation (GO:0043304)2.99960876
62DNA catabolic process, exonucleolytic (GO:0000738)2.99659008
63mechanosensory behavior (GO:0007638)2.98644886
64long-term synaptic potentiation (GO:0060291)2.98625331
65nuclear pore complex assembly (GO:0051292)2.95729366
66nucleobase catabolic process (GO:0046113)2.95576095
67regulation of synaptic transmission, glutamatergic (GO:0051966)2.95393403
68positive regulation of protein homooligomerization (GO:0032464)2.95331480
69catecholamine transport (GO:0051937)2.94787875
70negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94731030
71retinal rod cell development (GO:0046548)2.93903347
72mismatch repair (GO:0006298)2.92135082
73layer formation in cerebral cortex (GO:0021819)2.91208302
74respiratory burst (GO:0045730)2.90276260
75regulation of neuronal synaptic plasticity (GO:0048168)2.89623894
76positive regulation of synapse assembly (GO:0051965)2.88634373
77chaperone mediated protein folding requiring cofactor (GO:0051085)2.88381295
78mitochondrial RNA metabolic process (GO:0000959)2.87197739
79establishment of integrated proviral latency (GO:0075713)2.85870386
80gamma-aminobutyric acid signaling pathway (GO:0007214)2.85514848
81sensory perception of smell (GO:0007608)2.84379700
82establishment of viral latency (GO:0019043)2.83848750
83regulation of voltage-gated calcium channel activity (GO:1901385)2.83018857
84Arp2/3 complex-mediated actin nucleation (GO:0034314)2.82662799
85telomere maintenance via semi-conservative replication (GO:0032201)2.81809587
86mitotic nuclear envelope disassembly (GO:0007077)2.81503611
87neuromuscular process controlling balance (GO:0050885)2.81454504
88neuron recognition (GO:0008038)2.79490227
89auditory behavior (GO:0031223)2.79347511
90neutrophil activation involved in immune response (GO:0002283)2.77087097
91synapse assembly (GO:0007416)2.76307617
92gamma-aminobutyric acid transport (GO:0015812)2.75602963
93DNA replication initiation (GO:0006270)2.75562462
94axonal fasciculation (GO:0007413)2.75535383
95response to interferon-beta (GO:0035456)2.74927863
96nuclear envelope disassembly (GO:0051081)2.73615623
97membrane disassembly (GO:0030397)2.73615623
98regulation of mast cell activation involved in immune response (GO:0033006)2.72941667
99regulation of postsynaptic membrane potential (GO:0060078)2.72642049
100nuclear pore organization (GO:0006999)2.72572228
101positive thymic T cell selection (GO:0045059)2.72215789
102RNA methylation (GO:0001510)2.71591103
103positive regulation of membrane potential (GO:0045838)2.70333446
104response to auditory stimulus (GO:0010996)2.69708308
105cardiolipin metabolic process (GO:0032048)2.68725613
106IMP metabolic process (GO:0046040)2.68498079
107regulation of excitatory postsynaptic membrane potential (GO:0060079)2.68270916
108pyrimidine dimer repair (GO:0006290)2.67530495
109fear response (GO:0042596)2.67396489
110positive regulation of neurotransmitter secretion (GO:0001956)2.66171821
111membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65943803
112positive regulation of synapse maturation (GO:0090129)2.65033530
113cerebellar Purkinje cell differentiation (GO:0021702)2.63456670
114negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.62951287
115negative regulation of DNA-templated transcription, elongation (GO:0032785)2.61569874
116activation of protein kinase A activity (GO:0034199)2.61064816
117positive regulation of mitochondrial fission (GO:0090141)2.60677599
118lipopolysaccharide metabolic process (GO:0008653)2.60201164
119cell communication by electrical coupling (GO:0010644)2.59838241
120mitotic chromosome condensation (GO:0007076)2.59322325
121base-excision repair (GO:0006284)2.59267221
122N-acetylneuraminate metabolic process (GO:0006054)2.59147881
123neurotransmitter transport (GO:0006836)2.58682382
124positive regulation of synaptic transmission (GO:0050806)2.58477044
125synapse organization (GO:0050808)2.58197410
126negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.57743297
127positive regulation of neurotransmitter transport (GO:0051590)2.57464906
128positive regulation of gamma-delta T cell activation (GO:0046645)2.57404425
129behavioral response to ethanol (GO:0048149)2.57359028
130formation of translation preinitiation complex (GO:0001731)2.55502591
131positive regulation of vesicle fusion (GO:0031340)2.55443357
132tRNA modification (GO:0006400)2.54717041
133inner ear receptor cell development (GO:0060119)2.54356922
134pore complex assembly (GO:0046931)2.54116218
135regulation of long-term neuronal synaptic plasticity (GO:0048169)2.53628567
136membrane hyperpolarization (GO:0060081)2.52762630
137deoxyribonucleotide catabolic process (GO:0009264)2.51859739
138DNA unwinding involved in DNA replication (GO:0006268)2.50807877
139regulation of female receptivity (GO:0045924)2.50572675
140maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.50502404
141calcium-mediated signaling using intracellular calcium source (GO:0035584)2.50179525
142regulation of neurotransmitter secretion (GO:0046928)2.50153049
143regulation of synaptic plasticity (GO:0048167)2.49885280
144replication fork processing (GO:0031297)2.47810987
145respiratory system process (GO:0003016)2.47256586
146cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.47070702
147positive regulation of histone H3-K4 methylation (GO:0051571)2.46908798
148cerebellar Purkinje cell layer development (GO:0021680)2.46782607
149immunoglobulin mediated immune response (GO:0016064)2.46607811
150deoxyribose phosphate catabolic process (GO:0046386)2.46525200
151retinal cone cell development (GO:0046549)2.46135663
152proline transport (GO:0015824)2.45704391
153phosphatidylglycerol biosynthetic process (GO:0006655)2.45628486
154deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.45361782
155cell differentiation in hindbrain (GO:0021533)2.45284992
156activation of adenylate cyclase activity (GO:0007190)2.45223073
157glial cell proliferation (GO:0014009)2.44555688
158negative regulation of hormone metabolic process (GO:0032351)2.43105794
159negative regulation of hormone biosynthetic process (GO:0032353)2.43105794
160glucosamine-containing compound catabolic process (GO:1901072)2.42932991
161cellular potassium ion homeostasis (GO:0030007)2.42339368
162dendrite morphogenesis (GO:0048813)2.42192698
163nucleotide-excision repair, DNA gap filling (GO:0006297)2.41929694
164neuromuscular process (GO:0050905)2.41652686
165pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.41457917
166regulation of double-strand break repair via homologous recombination (GO:0010569)2.41414360
167regulation of beta-amyloid formation (GO:1902003)2.40512106
168DNA replication checkpoint (GO:0000076)2.38232126
169purine nucleobase biosynthetic process (GO:0009113)2.37521681
170regulation of myeloid leukocyte mediated immunity (GO:0002886)2.37479315
171purine nucleotide salvage (GO:0032261)2.37199471
172telomere maintenance via recombination (GO:0000722)2.37107965
173protein localization to chromosome, centromeric region (GO:0071459)2.36464884
174metallo-sulfur cluster assembly (GO:0031163)2.32989845
175iron-sulfur cluster assembly (GO:0016226)2.32989845
176modulation by virus of host process (GO:0019054)2.30191023
177DNA duplex unwinding (GO:0032508)2.29733275
178COPI coating of Golgi vesicle (GO:0048205)2.28936143
179Golgi transport vesicle coating (GO:0048200)2.28936143
180proline biosynthetic process (GO:0006561)2.27697543
181viral mRNA export from host cell nucleus (GO:0046784)2.26908774
182regulation of leukocyte degranulation (GO:0043300)2.26709917
183B cell mediated immunity (GO:0019724)2.26226789
184positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.25629366
185DNA geometric change (GO:0032392)2.25425291
186regulation of B cell receptor signaling pathway (GO:0050855)2.25352229
187rRNA modification (GO:0000154)2.25251516
188spliceosomal snRNP assembly (GO:0000387)2.24199592
189negative regulation of circadian rhythm (GO:0042754)2.23609417
190regulation of release of cytochrome c from mitochondria (GO:0090199)2.23439123
191DNA strand renaturation (GO:0000733)2.23256736
192tRNA aminoacylation for protein translation (GO:0006418)2.23240132
193positive regulation by symbiont of host defense response (GO:0052509)2.22792827
194modulation by symbiont of host defense response (GO:0052031)2.22792827
195modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.22792827
196modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.22792827
197positive regulation by organism of defense response of other organism involved in symbiotic interact2.22792827
198modulation by symbiont of host immune response (GO:0052553)2.22792827
199mitotic recombination (GO:0006312)2.22718740
200positive regulation of mast cell activation involved in immune response (GO:0033008)2.22698822

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.22551882
2EZH2_22144423_ChIP-Seq_EOC_Human5.58148912
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.52271699
4GBX2_23144817_ChIP-Seq_PC3_Human3.25348435
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21520936
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.20927326
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02141942
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.01927689
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.82941045
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81038388
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.80295681
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.77740566
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.77397911
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77061767
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77061767
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.72986307
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69970406
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69461247
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.66521839
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63819542
21TAF15_26573619_Chip-Seq_HEK293_Human2.62389665
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59556484
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59370078
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56968155
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.56638042
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49563708
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41209156
28* ETS1_20019798_ChIP-Seq_JURKAT_Human2.38224284
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.36932610
30CIITA_25753668_ChIP-Seq_RAJI_Human2.35242078
31E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33739214
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.32393916
33EST1_17652178_ChIP-ChIP_JURKAT_Human2.31812347
34EZH2_27294783_Chip-Seq_ESCs_Mouse2.29455981
35MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25283732
36THAP11_20581084_ChIP-Seq_MESCs_Mouse2.21887501
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18467687
38REST_21632747_ChIP-Seq_MESCs_Mouse2.16484958
39* VDR_23849224_ChIP-Seq_CD4+_Human2.16442746
40VDR_21846776_ChIP-Seq_THP-1_Human2.13455278
41NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13109642
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02507825
43* FOXP3_21729870_ChIP-Seq_TREG_Human2.01958764
44EGR1_19374776_ChIP-ChIP_THP-1_Human2.01153545
45GABP_19822575_ChIP-Seq_HepG2_Human1.99576561
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.97572317
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96348062
48XRN2_22483619_ChIP-Seq_HELA_Human1.95306393
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94856744
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94673050
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.94630627
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94242503
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92168348
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89440166
55* DCP1A_22483619_ChIP-Seq_HELA_Human1.89009293
56AR_21572438_ChIP-Seq_LNCaP_Human1.85019053
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84073290
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83878716
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83723735
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.83596885
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.82881832
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82264888
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.81789093
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78427749
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78179132
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76832792
67* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75542272
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.75146513
69DROSHA_22980978_ChIP-Seq_HELA_Human1.74444462
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.73805146
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72808558
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71201125
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.70697964
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70680751
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.68599995
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.65406557
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65316359
78* SPI1_23547873_ChIP-Seq_NB4_Human1.65205925
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64610769
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64120859
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63458146
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.63202314
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.62758400
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62539458
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61002614
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60894503
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60153246
88ELK1_19687146_ChIP-ChIP_HELA_Human1.59779740
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58874538
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58056478
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58035424
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57371316
93RARB_27405468_Chip-Seq_BRAIN_Mouse1.56437605
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.56057545
95MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54849119
96KDM5A_27292631_Chip-Seq_BREAST_Human1.53135371
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52496035
98RNF2_27304074_Chip-Seq_NSC_Mouse1.51677150
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50296220
100ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50051270
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49815024
102MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48415837
103MYC_22102868_ChIP-Seq_BL_Human1.47471828
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47166914
105TFEB_21752829_ChIP-Seq_HELA_Human1.46347615
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45352428
107IGF1R_20145208_ChIP-Seq_DFB_Human1.45078516
108RING1B_27294783_Chip-Seq_ESCs_Mouse1.44655303
109TTF2_22483619_ChIP-Seq_HELA_Human1.44072978
110SMAD4_21799915_ChIP-Seq_A2780_Human1.44025660
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43012307
112YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41900870
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41036850
114ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39872003
115P300_19829295_ChIP-Seq_ESCs_Human1.37494218
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.37082961
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34955592
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34751429
119MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32132962
120IRF8_22096565_ChIP-ChIP_GC-B_Human1.31645091
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30213937
122FOXM1_23109430_ChIP-Seq_U2OS_Human1.29913311
123PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29725339
124SMAD3_21741376_ChIP-Seq_EPCs_Human1.29369246
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26982978
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26594662
127MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24254007
128ZNF274_21170338_ChIP-Seq_K562_Hela1.23747542
129STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22408302
130MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21150217
131MAF_26560356_Chip-Seq_TH1_Human1.20301450
132IRF1_19129219_ChIP-ChIP_H3396_Human1.17421426
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15632113
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15065898
135RING1B_27294783_Chip-Seq_NPCs_Mouse1.14103212
136UTX_26944678_Chip-Seq_JUKART_Human1.12882174
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12734474
138CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09843278
139BCAT_22108803_ChIP-Seq_LS180_Human1.09756591
140VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08943427
141PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08473074
142AR_25329375_ChIP-Seq_VCAP_Human1.08039473
143PIAS1_25552417_ChIP-Seq_VCAP_Human1.07804168
144POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07190075
145CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07176766
146EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06961706
147VDR_24763502_ChIP-Seq_THP-1_Human1.06551160
148MAF_26560356_Chip-Seq_TH2_Human1.06164943
149BP1_19119308_ChIP-ChIP_Hs578T_Human1.04787272
150NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04767754
151SMAD_19615063_ChIP-ChIP_OVARY_Human1.04324286
152KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02950870
153CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02820184
154RUNX1_22412390_ChIP-Seq_EML_Mouse1.01342113
155WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00483615
156SOX2_21211035_ChIP-Seq_LN229_Gbm1.00359625
157SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98914324
158ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96472962
159NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96263412
160MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96218656
161TP53_20018659_ChIP-ChIP_R1E_Mouse0.95502892
162TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94499509
163SMAD3_21741376_ChIP-Seq_ESCs_Human0.93809309
164* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92847183
165MYB_26560356_Chip-Seq_TH1_Human0.92630926
166ELF1_20517297_ChIP-Seq_JURKAT_Human0.91590823
167WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90329794
168PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90273313
169MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88820543
170CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88620593
171SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87472703
172SMAD4_21741376_ChIP-Seq_HESCs_Human0.86805039
173RUNX2_22187159_ChIP-Seq_PCA_Human0.86216798
174BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85995586
175CTCF_27219007_Chip-Seq_Bcells_Human0.85452306
176MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84360241
177STAT3_23295773_ChIP-Seq_U87_Human0.84343731
178KDM2B_26808549_Chip-Seq_REH_Human0.84277584
179AR_19668381_ChIP-Seq_PC3_Human0.83714201
180ARNT_22903824_ChIP-Seq_MCF-7_Human0.83610200
181DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82057063
182TET1_21490601_ChIP-Seq_MESCs_Mouse0.81714501
183YAP1_20516196_ChIP-Seq_MESCs_Mouse0.81020111
184TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80923726
185AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80122874
186FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.80031968
187TP53_18474530_ChIP-ChIP_U2OS_Human0.78879105
188VDR_22108803_ChIP-Seq_LS180_Human0.78714485
189PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78469956
190OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.77984466
191NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77075797
192CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.76926942
193TCF4_23295773_ChIP-Seq_U87_Human0.75443301
194* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.75407830
195RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.74072848
196RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.73907030
197LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.72672762
198P53_22127205_ChIP-Seq_FIBROBLAST_Human0.72635095
199SMAD4_21741376_ChIP-Seq_EPCs_Human0.72611210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.95132060
2MP0004859_abnormal_synaptic_plasticity4.23639203
3MP0001984_abnormal_olfaction3.72511470
4MP0005645_abnormal_hypothalamus_physiol3.48756631
5MP0003806_abnormal_nucleotide_metabolis3.39555777
6MP0003635_abnormal_synaptic_transmissio3.22754149
7MP0003183_abnormal_peptide_metabolism3.16446915
8MP0003111_abnormal_nucleus_morphology3.08557535
9MP0008057_abnormal_DNA_replication3.04219379
10MP0003693_abnormal_embryo_hatching2.99380246
11MP0009278_abnormal_bone_marrow2.97473830
12MP0008058_abnormal_DNA_repair2.96551597
13MP0010094_abnormal_chromosome_stability2.88648554
14MP0004270_analgesia2.82989292
15MP0003077_abnormal_cell_cycle2.66101086
16MP0009745_abnormal_behavioral_response2.65672374
17MP0009046_muscle_twitch2.56231527
18MP0001968_abnormal_touch/_nociception2.48461892
19MP0010234_abnormal_vibrissa_follicle2.45417285
20MP0002063_abnormal_learning/memory/cond2.43118861
21MP0002064_seizures2.40455467
22MP0003303_peritoneal_inflammation2.38558006
23MP0001835_abnormal_antigen_presentation2.32753231
24MP0002572_abnormal_emotion/affect_behav2.20005195
25MP0009780_abnormal_chondrocyte_physiolo2.18997573
26MP0001486_abnormal_startle_reflex2.17261518
27MP0003329_amyloid_beta_deposits2.13916864
28MP0002837_dystrophic_cardiac_calcinosis2.11104974
29MP0000372_irregular_coat_pigmentation2.09340986
30MP0002184_abnormal_innervation2.06901955
31MP0003879_abnormal_hair_cell2.04239391
32MP0002272_abnormal_nervous_system2.03678237
33MP0005551_abnormal_eye_electrophysiolog2.02818861
34MP0004957_abnormal_blastocyst_morpholog2.00822366
35MP0003718_maternal_effect1.94518407
36MP0003787_abnormal_imprinting1.91472875
37MP0000685_abnormal_immune_system1.90182586
38MP0001545_abnormal_hematopoietic_system1.86684304
39MP0005397_hematopoietic_system_phenotyp1.86684304
40MP0002734_abnormal_mechanical_nocicepti1.84485722
41MP0002909_abnormal_adrenal_gland1.84387597
42MP0008932_abnormal_embryonic_tissue1.82661144
43MP0005451_abnormal_body_composition1.81480193
44MP0009840_abnormal_foam_cell1.81333208
45MP0001502_abnormal_circadian_rhythm1.76065786
46MP0002067_abnormal_sensory_capabilities1.74667228
47MP0002419_abnormal_innate_immunity1.72953275
48MP0008260_abnormal_autophagy1.65991488
49MP0005058_abnormal_lysosome_morphology1.65855463
50MP0010352_gastrointestinal_tract_polyps1.65465909
51MP0006035_abnormal_mitochondrial_morpho1.65297047
52MP0001440_abnormal_grooming_behavior1.64144559
53MP0008569_lethality_at_weaning1.63326471
54MP0008995_early_reproductive_senescence1.61852491
55MP0005075_abnormal_melanosome_morpholog1.61617801
56MP0005423_abnormal_somatic_nervous1.58654884
57MP0002090_abnormal_vision1.58463859
58MP0003436_decreased_susceptibility_to1.58264978
59MP0002638_abnormal_pupillary_reflex1.57503906
60MP0002557_abnormal_social/conspecific_i1.56998226
61MP0000778_abnormal_nervous_system1.55042997
62MP0001853_heart_inflammation1.54684513
63MP0002452_abnormal_antigen_presenting1.53047838
64MP0002733_abnormal_thermal_nociception1.52710932
65MP0000689_abnormal_spleen_morphology1.51778652
66MP0000631_abnormal_neuroendocrine_gland1.51251215
67MP0001529_abnormal_vocalization1.49068150
68MP0002398_abnormal_bone_marrow1.47674805
69MP0005025_abnormal_response_to1.47134857
70MP0002723_abnormal_immune_serum1.45715161
71MP0002019_abnormal_tumor_incidence1.45576566
72MP0006072_abnormal_retinal_apoptosis1.45335376
73MP0008007_abnormal_cellular_replicative1.44731249
74MP0002722_abnormal_immune_system1.44053454
75MP0002882_abnormal_neuron_morphology1.43621200
76MP0001501_abnormal_sleep_pattern1.43589230
77MP0003786_premature_aging1.42651888
78MP0002420_abnormal_adaptive_immunity1.42506386
79MP0001819_abnormal_immune_cell1.41475145
80MP0005646_abnormal_pituitary_gland1.41358647
81MP0001970_abnormal_pain_threshold1.39476885
82MP0001800_abnormal_humoral_immune1.36635627
83MP0000716_abnormal_immune_system1.36347330
84MP0000015_abnormal_ear_pigmentation1.32554740
85MP0001986_abnormal_taste_sensitivity1.32279346
86MP0010307_abnormal_tumor_latency1.31663843
87MP0000313_abnormal_cell_death1.31036620
88MP0009333_abnormal_splenocyte_physiolog1.30972576
89MP0002736_abnormal_nociception_after1.30717831
90MP0002752_abnormal_somatic_nervous1.29776843
91MP0000703_abnormal_thymus_morphology1.29239513
92MP0004924_abnormal_behavior1.28966058
93MP0005386_behavior/neurological_phenoty1.28966058
94MP0002405_respiratory_system_inflammati1.28302434
95MP0006276_abnormal_autonomic_nervous1.27884527
96MP0002429_abnormal_blood_cell1.26223779
97MP0000465_gastrointestinal_hemorrhage1.25633375
98MP0005499_abnormal_olfactory_system1.25406261
99MP0005394_taste/olfaction_phenotype1.25406261
100MP0005671_abnormal_response_to1.24942127
101MP0005623_abnormal_meninges_morphology1.24902930
102MP0008875_abnormal_xenobiotic_pharmacok1.24680330
103MP0000358_abnormal_cell_content/1.22718415
104MP0003172_abnormal_lysosome_physiology1.22513998
105MP0002735_abnormal_chemical_nociception1.21702621
106MP0002160_abnormal_reproductive_system1.20985653
107MP0002822_catalepsy1.18432525
108MP0000955_abnormal_spinal_cord1.18391441
109MP0005000_abnormal_immune_tolerance1.18002001
110MP0000350_abnormal_cell_proliferation1.17934555
111MP0005408_hypopigmentation1.16455437
112MP0008789_abnormal_olfactory_epithelium1.16306633
113MP0004233_abnormal_muscle_weight1.16246069
114MP0003633_abnormal_nervous_system1.14473948
115MP0004858_abnormal_nervous_system1.14310152
116MP0003763_abnormal_thymus_physiology1.13334150
117MP0004130_abnormal_muscle_cell1.13215891
118MP0002066_abnormal_motor_capabilities/c1.11988633
119MP0001963_abnormal_hearing_physiology1.11863866
120MP0002229_neurodegeneration1.11500325
121MP0001764_abnormal_homeostasis1.10830588
122MP0002009_preneoplasia1.09445283
123MP0002166_altered_tumor_susceptibility1.09431888
124MP0003121_genomic_imprinting1.06355537
125MP0000681_abnormal_thyroid_gland1.05568885
126MP0000604_amyloidosis1.03508712
127MP0008469_abnormal_protein_level1.01780804
128MP0001730_embryonic_growth_arrest1.01457852
129MP0005365_abnormal_bile_salt1.00845825
130MP0002152_abnormal_brain_morphology1.00081040
131MP0002102_abnormal_ear_morphology1.00005117
132MP0003868_abnormal_feces_composition0.99306606
133MP0004885_abnormal_endolymph0.99111574
134MP0005380_embryogenesis_phenotype0.98292423
135MP0001672_abnormal_embryogenesis/_devel0.98292423
136MP0001929_abnormal_gametogenesis0.98251614
137MP0004197_abnormal_fetal_growth/weight/0.96928389
138MP0003690_abnormal_glial_cell0.96635436
139MP0001790_abnormal_immune_system0.95765106
140MP0005387_immune_system_phenotype0.95765106
141MP0005253_abnormal_eye_physiology0.95437149
142MP0003186_abnormal_redox_activity0.95435291
143MP0003221_abnormal_cardiomyocyte_apopto0.95224555
144MP0000013_abnormal_adipose_tissue0.94840602
145MP0004742_abnormal_vestibular_system0.94798777
146MP0005389_reproductive_system_phenotype0.93567812
147MP0002006_tumorigenesis0.92938768
148MP0001119_abnormal_female_reproductive0.92161009
149MP0001324_abnormal_eye_pigmentation0.91857160
150MP0000751_myopathy0.91813720
151MP0005464_abnormal_platelet_physiology0.91770150
152MP0003634_abnormal_glial_cell0.91429168
153MP0004811_abnormal_neuron_physiology0.91070898
154MP0000026_abnormal_inner_ear0.90967757
155MP0001845_abnormal_inflammatory_respons0.90071917
156MP0000371_diluted_coat_color0.89876466
157MP0003984_embryonic_growth_retardation0.89532549
158MP0004808_abnormal_hematopoietic_stem0.89256011
159MP0003631_nervous_system_phenotype0.89251971
160MP0003122_maternal_imprinting0.89083015
161MP0004142_abnormal_muscle_tone0.87800638
162MP0002396_abnormal_hematopoietic_system0.86687144
163MP0006036_abnormal_mitochondrial_physio0.86489040
164MP0005195_abnormal_posterior_eye0.86193879
165MP0002249_abnormal_larynx_morphology0.85980452
166MP0005384_cellular_phenotype0.85312269
167MP0002080_prenatal_lethality0.83418552
168MP0001905_abnormal_dopamine_level0.83252586
169MP0002088_abnormal_embryonic_growth/wei0.82529545
170MP0001697_abnormal_embryo_size0.82381399
171MP0005535_abnormal_body_temperature0.82380331
172MP0003300_gastrointestinal_ulcer0.80802644
173MP0002876_abnormal_thyroid_physiology0.79193806
174MP0002210_abnormal_sex_determination0.78800653
175MP0001293_anophthalmia0.78721626
176MP0009697_abnormal_copulation0.78165232
177MP0008877_abnormal_DNA_methylation0.77710667
178MP0009785_altered_susceptibility_to0.77129981
179MP0003283_abnormal_digestive_organ0.76902260
180MP0001188_hyperpigmentation0.75731413
181MP0008874_decreased_physiological_sensi0.75497957
182MP0005187_abnormal_penis_morphology0.72076863
183MP0004085_abnormal_heartbeat0.71300098
184MP0002069_abnormal_eating/drinking_beha0.69704405
185MP0010678_abnormal_skin_adnexa0.69540506
186MP0000579_abnormal_nail_morphology0.68963847
187MP0003075_altered_response_to0.68788164
188MP0004215_abnormal_myocardial_fiber0.68412875
189MP0003123_paternal_imprinting0.67967172
190MP0003632_abnormal_nervous_system0.67782296
191MP0004145_abnormal_muscle_electrophysio0.67759719
192MP0004185_abnormal_adipocyte_glucose0.66312291
193MP0003953_abnormal_hormone_level0.64247659
194MP0000920_abnormal_myelination0.62520630
195MP0001944_abnormal_pancreas_morphology0.61040046
196MP0001727_abnormal_embryo_implantation0.60292394
197MP0010386_abnormal_urinary_bladder0.59427901
198MP0002078_abnormal_glucose_homeostasis0.57199653
199MP0003137_abnormal_impulse_conducting0.56715748

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.77007193
2Visual hallucinations (HP:0002367)4.49671576
3Epileptic encephalopathy (HP:0200134)4.42171743
4Congenital stationary night blindness (HP:0007642)4.33727768
5Recurrent cutaneous fungal infections (HP:0011370)4.25791738
6Chronic mucocutaneous candidiasis (HP:0002728)4.25791738
7Hyperventilation (HP:0002883)4.10796843
8Neurofibrillary tangles (HP:0002185)4.05104563
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.88273338
10Atonic seizures (HP:0010819)3.75821551
11Upper motor neuron abnormality (HP:0002127)3.61381124
12Microvesicular hepatic steatosis (HP:0001414)3.55588603
13Cerebral inclusion bodies (HP:0100314)3.55542364
14Panhypogammaglobulinemia (HP:0003139)3.52853375
15Febrile seizures (HP:0002373)3.52443813
16Agammaglobulinemia (HP:0004432)3.51169625
17Hypothermia (HP:0002045)3.47069562
18Colitis (HP:0002583)3.41548146
19Focal seizures (HP:0007359)3.36187410
20Absence seizures (HP:0002121)3.11592605
21Increased serum pyruvate (HP:0003542)3.04935298
22Eczematoid dermatitis (HP:0000976)3.02706408
23Supranuclear gaze palsy (HP:0000605)2.97897526
24Myokymia (HP:0002411)2.97355294
25Retinal dysplasia (HP:0007973)2.93358963
26Squamous cell carcinoma (HP:0002860)2.92044834
27Generalized tonic-clonic seizures (HP:0002069)2.87155038
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83337805
29Recurrent fungal infections (HP:0002841)2.82558789
30Abnormality of macrophages (HP:0004311)2.79001532
31Mediastinal lymphadenopathy (HP:0100721)2.77218566
32Multiple enchondromatosis (HP:0005701)2.77058889
33Vacuolated lymphocytes (HP:0001922)2.69193586
34Agitation (HP:0000713)2.67722322
35Bony spicule pigmentary retinopathy (HP:0007737)2.67695427
36Abnormality of glycolysis (HP:0004366)2.67485596
37Thyroid-stimulating hormone excess (HP:0002925)2.66805706
38Viral hepatitis (HP:0006562)2.65512504
39Gait imbalance (HP:0002141)2.65296070
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.65273673
41Abnormal rod and cone electroretinograms (HP:0008323)2.65005394
42Dialeptic seizures (HP:0011146)2.61750208
43Clumsiness (HP:0002312)2.61298839
44Elevated erythrocyte sedimentation rate (HP:0003565)2.60758708
45Delayed CNS myelination (HP:0002188)2.58997603
46Hepatosplenomegaly (HP:0001433)2.57389179
47Epileptiform EEG discharges (HP:0011182)2.57163021
48Hypoplastic pelvis (HP:0008839)2.54901317
49Narrow nasal bridge (HP:0000446)2.53698387
50Excessive salivation (HP:0003781)2.53379004
51Drooling (HP:0002307)2.53379004
52Abnormality of small intestinal villus morphology (HP:0011472)2.52897621
53Villous atrophy (HP:0011473)2.52897621
54Abnormality of T cell physiology (HP:0011840)2.52368786
55Anxiety (HP:0000739)2.50532122
56Recurrent bacterial skin infections (HP:0005406)2.50211701
57Recurrent skin infections (HP:0001581)2.49271448
58Cortical dysplasia (HP:0002539)2.48594107
59Progressive muscle weakness (HP:0003323)2.47812955
60Broad-based gait (HP:0002136)2.47678385
61Ketoacidosis (HP:0001993)2.46475940
62EEG with generalized epileptiform discharges (HP:0011198)2.46212731
63Hemiplegia (HP:0002301)2.44667255
64Hypercortisolism (HP:0001578)2.43742171
65Recurrent abscess formation (HP:0002722)2.43380128
66Cutaneous melanoma (HP:0012056)2.42864200
67Depression (HP:0000716)2.42832426
68Meckel diverticulum (HP:0002245)2.42016984
69Rough bone trabeculation (HP:0100670)2.41574046
70Psychosis (HP:0000709)2.39448991
71Prolonged neonatal jaundice (HP:0006579)2.38927915
72Poor suck (HP:0002033)2.36289455
73Severe visual impairment (HP:0001141)2.35630230
74Decreased electroretinogram (ERG) amplitude (HP:0000654)2.35447435
75Progressive external ophthalmoplegia (HP:0000590)2.34574567
76Aplasia/Hypoplasia of the lens (HP:0008063)2.33517028
77Brushfield spots (HP:0001088)2.32881172
78Abnormality of the preputium (HP:0100587)2.32469477
79Hypsarrhythmia (HP:0002521)2.30462930
80Decreased central vision (HP:0007663)2.29840676
81Oligomenorrhea (HP:0000876)2.29433910
82Bone marrow hypocellularity (HP:0005528)2.29190122
83Abnormality of the ileum (HP:0001549)2.27519942
84Truncal ataxia (HP:0002078)2.25540081
85Hemiparesis (HP:0001269)2.24893618
86Conjugated hyperbilirubinemia (HP:0002908)2.24792357
87Keratoconus (HP:0000563)2.24287741
88Increased corneal curvature (HP:0100692)2.24287741
89Poor eye contact (HP:0000817)2.23535409
90Medulloblastoma (HP:0002885)2.22632429
91Congenital primary aphakia (HP:0007707)2.21655578
92Abnormality of T cells (HP:0002843)2.19474291
93Meningitis (HP:0001287)2.18425334
94Impaired social interactions (HP:0000735)2.18415353
95Abnormal social behavior (HP:0012433)2.18415353
96Gastrointestinal inflammation (HP:0004386)2.17712959
97Ankle clonus (HP:0011448)2.17610733
98Inflammation of the large intestine (HP:0002037)2.16747348
99Hand muscle atrophy (HP:0009130)2.16630734
100Nephrogenic diabetes insipidus (HP:0009806)2.15302960
101Exotropia (HP:0000577)2.15143952
102Generalized myoclonic seizures (HP:0002123)2.14884754
103Granulocytopenia (HP:0001913)2.13927532
104Respiratory difficulties (HP:0002880)2.11202788
105Abnormality of the lower motor neuron (HP:0002366)2.11061632
106Abnormality of chromosome stability (HP:0003220)2.09524038
107Polyphagia (HP:0002591)2.09334064
108Restlessness (HP:0000711)2.08855243
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.07991827
110Recurrent viral infections (HP:0004429)2.07068839
111Blue irides (HP:0000635)2.06142980
112Leukopenia (HP:0001882)2.05538687
113Cellular immunodeficiency (HP:0005374)2.05479838
114Abnormal eating behavior (HP:0100738)2.05303238
115Abnormality of the parathyroid morphology (HP:0011766)2.04447557
116Ketosis (HP:0001946)2.02868379
117Abnormality of liposaccharide metabolism (HP:0010968)2.01194070
118Abnormality of glycosphingolipid metabolism (HP:0004343)2.01194070
119Abnormality of glycolipid metabolism (HP:0010969)2.01194070
120Ragged-red muscle fibers (HP:0003200)1.99527556
121Cortical visual impairment (HP:0100704)1.98131884
122Chromsome breakage (HP:0040012)1.97004625
123Encephalitis (HP:0002383)1.95699177
124Aplasia/Hypoplasia of the uvula (HP:0010293)1.95652664
125Combined immunodeficiency (HP:0005387)1.92584329
126Obstructive lung disease (HP:0006536)1.90919614
127Chronic obstructive pulmonary disease (HP:0006510)1.90919614
128Tinnitus (HP:0000360)1.90236018
129Megalencephaly (HP:0001355)1.90194440
130Severe global developmental delay (HP:0011344)1.90095327
131Small intestinal stenosis (HP:0012848)1.89111778
132Duodenal stenosis (HP:0100867)1.89111778
133Lymphoma (HP:0002665)1.88509256
134Horseshoe kidney (HP:0000085)1.88424005
135Hypoplasia of the iris (HP:0007676)1.88356900
136Colon cancer (HP:0003003)1.87821528
137Optic nerve coloboma (HP:0000588)1.87617230
138Status epilepticus (HP:0002133)1.87586824
139Hypertensive crisis (HP:0100735)1.87554880
140Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.87552433
141Postural instability (HP:0002172)1.86408908
142Stereotypic behavior (HP:0000733)1.86253947
143Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85790934
144Abnormal trabecular bone morphology (HP:0100671)1.85317054
145Medial flaring of the eyebrow (HP:0010747)1.84712065
146Cutaneous photosensitivity (HP:0000992)1.84664109
147Hepatoblastoma (HP:0002884)1.84274371
148Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83622326
149Abnormality of alanine metabolism (HP:0010916)1.83622326
150Hyperalaninemia (HP:0003348)1.83622326
151Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83383859
152Impaired smooth pursuit (HP:0007772)1.83077961
153Loss of speech (HP:0002371)1.82443467
154Premature graying of hair (HP:0002216)1.82249439
155Amyotrophic lateral sclerosis (HP:0007354)1.82034933
156Severe Myopia (HP:0011003)1.81250683
157Abnormality of lateral ventricle (HP:0030047)1.80673570
158Genital tract atresia (HP:0001827)1.80424967
159Inability to walk (HP:0002540)1.80303622
160Dysdiadochokinesis (HP:0002075)1.79735473
161Hydroureter (HP:0000072)1.79688311
162Abnormal gallbladder physiology (HP:0012438)1.79458696
163Cholecystitis (HP:0001082)1.79458696
164Trismus (HP:0000211)1.78836491
165Abnormality of the carotid arteries (HP:0005344)1.78136535
166Akinesia (HP:0002304)1.78004246
167Morphological abnormality of the middle ear (HP:0008609)1.77689100
168Postural tremor (HP:0002174)1.77391316
169Neutropenia (HP:0001875)1.77229143
170Fatigue (HP:0012378)1.77119610
171Basal cell carcinoma (HP:0002671)1.76648520
172Abnormal sex determination (HP:0012244)1.76587097
173Sex reversal (HP:0012245)1.76587097
174Hyperglycinemia (HP:0002154)1.75293116
175Progressive neurologic deterioration (HP:0002344)1.75187761
176Abnormality of macular pigmentation (HP:0008002)1.74951141
177Severe combined immunodeficiency (HP:0004430)1.74875411
178Cleft eyelid (HP:0000625)1.74285197
179Delayed myelination (HP:0012448)1.74191042
180Hypoventilation (HP:0002791)1.73902967
181Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73281317
182Partial agenesis of the corpus callosum (HP:0001338)1.73237853
183Premature ovarian failure (HP:0008209)1.72902620
184IgM deficiency (HP:0002850)1.72858367
185Scanning speech (HP:0002168)1.72410021
186True hermaphroditism (HP:0010459)1.71674451
187Generalized hypopigmentation of hair (HP:0011358)1.71359942
188Tracheoesophageal fistula (HP:0002575)1.70855267
189Mutism (HP:0002300)1.70744169
190Specific learning disability (HP:0001328)1.70524848
191Absent speech (HP:0001344)1.70165667
192Progressive hearing impairment (HP:0001730)1.69091737
193Lower limb hyperreflexia (HP:0002395)1.68163232
194Agnosia (HP:0010524)1.67365293
195Poikiloderma (HP:0001029)1.65855925
196Acute hepatic failure (HP:0006554)1.64463392
197Horizontal nystagmus (HP:0000666)1.64199631
198Increased serum ferritin (HP:0003281)1.62195000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK26.76611734
2SRPK14.12126314
3STK163.99411342
4CASK3.45105463
5CDK193.13214577
6IRAK43.13080831
7PHKG13.06953347
8PHKG23.06953347
9NTRK33.02861342
10EPHA43.02239606
11MARK12.75377426
12EPHB12.72489005
13MAP3K92.68761765
14TRIM282.65783895
15SIK32.46960525
16TNIK2.37826590
17DAPK22.30000005
18ZAK2.08731679
19ACVR1B2.04767585
20MAP4K12.02865860
21BCR2.02394950
22MAP3K121.92959575
23BMPR1B1.88901512
24RPS6KA41.86905052
25MAP2K71.79682150
26CDC71.73489785
27MAP2K31.70230100
28NTRK21.66231097
29TGFBR11.62283923
30GRK71.57892021
31EIF2AK11.51860726
32CAMKK21.49064652
33MAP3K41.45580236
34NTRK11.45297502
35RIPK41.44425920
36SIK21.44210158
37DAPK11.43264334
38MAPK131.41941142
39PAK61.39072230
40GRK61.38164376
41BRD41.37543864
42TXK1.33329715
43MAP3K131.32203327
44GRK51.30905681
45EIF2AK31.29218246
46LMTK21.27504541
47FGFR41.25528690
48PDK31.25288951
49PDK41.25288951
50INSRR1.24262302
51MINK11.23842126
52MAP3K31.23667152
53CDK81.22341706
54MAPK151.21791929
55NME21.17405606
56EPHA31.16520069
57NUAK11.15506844
58MUSK1.12782470
59FES1.12395763
60OXSR11.11085245
61ATR1.07858971
62SCYL21.05630879
63PIM21.02244377
64RAF10.99722260
65CDK50.98935302
66CAMKK10.98295073
67CDK70.97039581
68TSSK60.96379647
69BLK0.95460627
70FGFR30.95341013
71FLT30.95224813
72CAMK2A0.94572793
73HIPK20.93022849
74RIPK10.92407107
75RPS6KA50.91994506
76ARAF0.91743979
77MAP2K40.91534021
78PLK40.90856697
79CSNK1A1L0.89628220
80TGFBR20.87478983
81CAMK2B0.87289399
82AURKA0.85843140
83CSNK1G20.82731086
84CAMK2D0.77783284
85TTK0.77075768
86IRAK10.76523139
87CSK0.76029376
88PIM10.75470693
89PLK10.75284232
90DYRK20.74196863
91TBK10.73103200
92ALK0.72582503
93JAK20.72273995
94MAP3K110.71370376
95LATS20.71081742
96EEF2K0.68225219
97KSR10.66931452
98SGK4940.66397037
99SGK2230.66397037
100IKBKE0.66162066
101KSR20.66129735
102MOS0.65875413
103EPHB20.65468514
104DYRK1B0.63529925
105MYLK0.63379390
106PRKCE0.62810440
107CAMK2G0.62611829
108PRPF4B0.62161329
109CSNK1G30.61923872
110MAP3K80.61063660
111ADRBK10.60822354
112MAPK110.60498179
113HCK0.59319635
114PLK20.58411819
115PRKCG0.57634547
116CDK40.57428052
117VRK10.57250041
118ERBB30.57249566
119TIE10.55982767
120CDK90.55390593
121CHEK10.55382859
122BRSK20.54518180
123STK110.53730461
124SMG10.52167924
125DYRK1A0.51336493
126NEK10.50422162
127BCKDK0.49735151
128AKT20.49439635
129FGR0.49289659
130LYN0.48922500
131TESK10.48561212
132AURKB0.48541912
133JAK30.48318862
134NEK90.47025930
135CSF1R0.46883223
136MAPKAPK50.46479430
137GRK10.45938091
138ATM0.45628719
139PLK30.44540094
140TYK20.44191720
141PDK10.43670385
142CHUK0.42850756
143MKNK10.42792135
144CHEK20.41842373
145CDK20.41745357
146PKN20.41540383
147SGK10.41066034
148CAMK10.40188376
149PRKAA20.39695016
150CSNK1G10.39618528
151BTK0.39569458
152SIK10.39360789
153FER0.38879439
154TLK10.38594720
155PDK20.38405447
156IKBKB0.38199970
157MAP3K100.38157568
158CAMK1G0.37532188
159PRKG10.36457068
160MAPKAPK20.36360063
161DAPK30.36179817
162TAOK30.34607588
163ERN10.33746389
164BRAF0.33646975
165MAP3K140.33616406
166PRKACA0.33601156
167TRIB30.32767281
168UHMK10.31665412
169DYRK30.31613798
170WNK30.30952417
171STK380.30885758
172CAMK1D0.29423466
173MAPK120.28935513
174PAK30.28512785

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.42398937
2DNA replication_Homo sapiens_hsa030303.38972468
3Mismatch repair_Homo sapiens_hsa034303.14467957
4Nicotine addiction_Homo sapiens_hsa050333.06602533
5Synaptic vesicle cycle_Homo sapiens_hsa047212.80126729
6Base excision repair_Homo sapiens_hsa034102.75749509
7Fanconi anemia pathway_Homo sapiens_hsa034602.64173567
8Antigen processing and presentation_Homo sapiens_hsa046122.61693347
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49165022
10Phototransduction_Homo sapiens_hsa047442.37320979
11Spliceosome_Homo sapiens_hsa030402.31656234
12Homologous recombination_Homo sapiens_hsa034402.22751876
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19762425
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.19584260
15GABAergic synapse_Homo sapiens_hsa047272.18573876
16Proteasome_Homo sapiens_hsa030502.14206477
17Morphine addiction_Homo sapiens_hsa050322.12677385
18Glutamatergic synapse_Homo sapiens_hsa047242.08920479
19RNA transport_Homo sapiens_hsa030132.08806606
20Circadian entrainment_Homo sapiens_hsa047132.06738294
21Amphetamine addiction_Homo sapiens_hsa050312.05002017
22Insulin secretion_Homo sapiens_hsa049112.00740160
23Cell cycle_Homo sapiens_hsa041101.92015694
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87670217
25RNA polymerase_Homo sapiens_hsa030201.85264126
26Renin secretion_Homo sapiens_hsa049241.78290166
27Other glycan degradation_Homo sapiens_hsa005111.71793873
28Dopaminergic synapse_Homo sapiens_hsa047281.66254701
29Primary immunodeficiency_Homo sapiens_hsa053401.66019546
30Pyrimidine metabolism_Homo sapiens_hsa002401.64938202
31Long-term potentiation_Homo sapiens_hsa047201.64580391
32Salivary secretion_Homo sapiens_hsa049701.63490766
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61312501
34Nucleotide excision repair_Homo sapiens_hsa034201.60285113
35Galactose metabolism_Homo sapiens_hsa000521.59733782
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59347794
37Cholinergic synapse_Homo sapiens_hsa047251.52428605
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49825348
39Collecting duct acid secretion_Homo sapiens_hsa049661.47425167
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46538762
41Systemic lupus erythematosus_Homo sapiens_hsa053221.43263350
42Cocaine addiction_Homo sapiens_hsa050301.43111277
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42596000
44Taste transduction_Homo sapiens_hsa047421.40009080
45Calcium signaling pathway_Homo sapiens_hsa040201.37451017
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.34944459
47Viral carcinogenesis_Homo sapiens_hsa052031.32935869
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32867403
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.32812419
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.32054718
51Butanoate metabolism_Homo sapiens_hsa006501.31238252
52Pentose phosphate pathway_Homo sapiens_hsa000301.30771382
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29517738
54Fatty acid biosynthesis_Homo sapiens_hsa000611.26859512
55Serotonergic synapse_Homo sapiens_hsa047261.25239973
56Epstein-Barr virus infection_Homo sapiens_hsa051691.24963439
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23675101
58Basal transcription factors_Homo sapiens_hsa030221.22325327
59Herpes simplex infection_Homo sapiens_hsa051681.21079191
60Gastric acid secretion_Homo sapiens_hsa049711.19661615
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18835838
62Shigellosis_Homo sapiens_hsa051311.15748828
63Long-term depression_Homo sapiens_hsa047301.14777520
64Fatty acid degradation_Homo sapiens_hsa000711.14557989
65Oxytocin signaling pathway_Homo sapiens_hsa049211.13506172
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08833493
67Axon guidance_Homo sapiens_hsa043601.08666084
68mRNA surveillance pathway_Homo sapiens_hsa030151.07232943
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06744579
70Fatty acid metabolism_Homo sapiens_hsa012121.05952473
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05508879
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04692583
73Non-homologous end-joining_Homo sapiens_hsa034501.04188963
74Maturity onset diabetes of the young_Homo sapiens_hsa049501.03858744
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03053035
76cAMP signaling pathway_Homo sapiens_hsa040241.02936556
77Steroid biosynthesis_Homo sapiens_hsa001001.00287211
78Viral myocarditis_Homo sapiens_hsa054160.99190432
79Vibrio cholerae infection_Homo sapiens_hsa051100.99187006
80Lysosome_Homo sapiens_hsa041420.98070366
81Apoptosis_Homo sapiens_hsa042100.97541132
82Carbon metabolism_Homo sapiens_hsa012000.96345385
83Glucagon signaling pathway_Homo sapiens_hsa049220.95969231
84RNA degradation_Homo sapiens_hsa030180.94567175
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92893381
86Acute myeloid leukemia_Homo sapiens_hsa052210.91963236
87Hepatitis B_Homo sapiens_hsa051610.89529417
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89054247
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.88588029
90Melanogenesis_Homo sapiens_hsa049160.88055849
91Tuberculosis_Homo sapiens_hsa051520.87640483
92Leishmaniasis_Homo sapiens_hsa051400.86447958
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85804551
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85394848
95Circadian rhythm_Homo sapiens_hsa047100.84470307
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.84012686
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83921418
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82279814
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81943001
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80935346
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80848526
102Measles_Homo sapiens_hsa051620.80804834
103GnRH signaling pathway_Homo sapiens_hsa049120.80398426
104Gap junction_Homo sapiens_hsa045400.78225225
105Pyruvate metabolism_Homo sapiens_hsa006200.77684650
106Allograft rejection_Homo sapiens_hsa053300.77152505
107Fatty acid elongation_Homo sapiens_hsa000620.76599777
108Propanoate metabolism_Homo sapiens_hsa006400.76293828
109Purine metabolism_Homo sapiens_hsa002300.75862796
110Phagosome_Homo sapiens_hsa041450.75359811
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74515355
112Type II diabetes mellitus_Homo sapiens_hsa049300.73915877
113Staphylococcus aureus infection_Homo sapiens_hsa051500.73377311
114Sulfur metabolism_Homo sapiens_hsa009200.72209462
115Nitrogen metabolism_Homo sapiens_hsa009100.72162425
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70923639
117Influenza A_Homo sapiens_hsa051640.70729676
118Autoimmune thyroid disease_Homo sapiens_hsa053200.70061583
119p53 signaling pathway_Homo sapiens_hsa041150.67608250
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64962583
121Osteoclast differentiation_Homo sapiens_hsa043800.64421599
122Estrogen signaling pathway_Homo sapiens_hsa049150.64231221
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63813366
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63513558
125Pancreatic secretion_Homo sapiens_hsa049720.62054719
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61566833
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.61111783
128Bile secretion_Homo sapiens_hsa049760.60349640
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59692431
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.58285887
131Graft-versus-host disease_Homo sapiens_hsa053320.57666412
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.57546077
133Tryptophan metabolism_Homo sapiens_hsa003800.56158473
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56034076
135Peroxisome_Homo sapiens_hsa041460.56016609
136Glioma_Homo sapiens_hsa052140.55486119
137Thyroid hormone synthesis_Homo sapiens_hsa049180.55456998
138Sulfur relay system_Homo sapiens_hsa041220.55272652
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54430000
140Parkinsons disease_Homo sapiens_hsa050120.54426308
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.54289285
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53772843
143Cardiac muscle contraction_Homo sapiens_hsa042600.53174431
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50989844
145Asthma_Homo sapiens_hsa053100.50173580
146Glutathione metabolism_Homo sapiens_hsa004800.49934166
147Lysine degradation_Homo sapiens_hsa003100.49885156
148B cell receptor signaling pathway_Homo sapiens_hsa046620.49274541
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48834642
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48759924
151Regulation of autophagy_Homo sapiens_hsa041400.48158844
152PPAR signaling pathway_Homo sapiens_hsa033200.47516424
153Cysteine and methionine metabolism_Homo sapiens_hsa002700.47328229
154Non-small cell lung cancer_Homo sapiens_hsa052230.47000668
155Legionellosis_Homo sapiens_hsa051340.46356410
156ErbB signaling pathway_Homo sapiens_hsa040120.46097567
157Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46037541
158N-Glycan biosynthesis_Homo sapiens_hsa005100.45751128
159Arginine biosynthesis_Homo sapiens_hsa002200.45413743
160Salmonella infection_Homo sapiens_hsa051320.44817821
161Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44393613
162Ras signaling pathway_Homo sapiens_hsa040140.43788249
163Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43762531
164Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43031552
165alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42982970
166Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42591570
167Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42483064
168Insulin signaling pathway_Homo sapiens_hsa049100.42396836
169Pancreatic cancer_Homo sapiens_hsa052120.41785219
170Ribosome_Homo sapiens_hsa030100.41331173
171Fructose and mannose metabolism_Homo sapiens_hsa000510.40475215
172Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40452777
173Prion diseases_Homo sapiens_hsa050200.40194318
174Adipocytokine signaling pathway_Homo sapiens_hsa049200.39358037
175HTLV-I infection_Homo sapiens_hsa051660.39113246
176Dilated cardiomyopathy_Homo sapiens_hsa054140.37527934
177Ovarian steroidogenesis_Homo sapiens_hsa049130.37256387
178Caffeine metabolism_Homo sapiens_hsa002320.36119985
179Alcoholism_Homo sapiens_hsa050340.35860135
180Sphingolipid metabolism_Homo sapiens_hsa006000.34135437
181Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33554694
182Phospholipase D signaling pathway_Homo sapiens_hsa040720.33345545
183Biosynthesis of amino acids_Homo sapiens_hsa012300.31822900
184Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31552457
185Oocyte meiosis_Homo sapiens_hsa041140.30892696

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