ZKSCAN7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.91344998
2L-phenylalanine catabolic process (GO:0006559)6.91344998
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.57603283
4L-phenylalanine metabolic process (GO:0006558)6.57603283
5aromatic amino acid family catabolic process (GO:0009074)6.13960997
6pyrimidine nucleobase catabolic process (GO:0006208)5.99216189
7alpha-linolenic acid metabolic process (GO:0036109)5.76753763
8indole-containing compound catabolic process (GO:0042436)5.56525259
9indolalkylamine catabolic process (GO:0046218)5.56525259
10tryptophan catabolic process (GO:0006569)5.56525259
11kynurenine metabolic process (GO:0070189)5.56216851
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.50761328
13urea cycle (GO:0000050)5.48873032
14urea metabolic process (GO:0019627)5.48873032
15bile acid biosynthetic process (GO:0006699)5.47937256
16tryptophan metabolic process (GO:0006568)5.26545096
17glyoxylate metabolic process (GO:0046487)5.25386160
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.22971733
19sulfur amino acid catabolic process (GO:0000098)5.14435975
20cysteine metabolic process (GO:0006534)5.13367742
21nitrogen cycle metabolic process (GO:0071941)4.99449144
22complement activation, alternative pathway (GO:0006957)4.98382427
23nucleobase catabolic process (GO:0046113)4.91671136
24negative regulation of fibrinolysis (GO:0051918)4.89964603
25regulation of protein activation cascade (GO:2000257)4.88696458
26high-density lipoprotein particle remodeling (GO:0034375)4.83527048
27peptidyl-glutamic acid carboxylation (GO:0017187)4.82400282
28protein carboxylation (GO:0018214)4.82400282
29bile acid metabolic process (GO:0008206)4.68846441
30behavioral response to nicotine (GO:0035095)4.68102614
31serine family amino acid catabolic process (GO:0009071)4.66858163
32regulation of fibrinolysis (GO:0051917)4.63271014
33lysine catabolic process (GO:0006554)4.63145356
34lysine metabolic process (GO:0006553)4.63145356
35regulation of complement activation (GO:0030449)4.59359871
36reverse cholesterol transport (GO:0043691)4.55171831
37homocysteine metabolic process (GO:0050667)4.52040726
38regulation of triglyceride catabolic process (GO:0010896)4.45463451
39gamma-aminobutyric acid transport (GO:0015812)4.43338054
40aromatic amino acid family metabolic process (GO:0009072)4.40166731
41response to pheromone (GO:0019236)4.38217857
42amino-acid betaine metabolic process (GO:0006577)4.38147126
43negative regulation of sterol transport (GO:0032372)4.34019376
44negative regulation of cholesterol transport (GO:0032375)4.34019376
45imidazole-containing compound metabolic process (GO:0052803)4.32926767
46alpha-amino acid catabolic process (GO:1901606)4.31007156
47presynaptic membrane assembly (GO:0097105)4.30187664
48coenzyme catabolic process (GO:0009109)4.29636169
49triglyceride homeostasis (GO:0070328)4.27776979
50acylglycerol homeostasis (GO:0055090)4.27776979
51tyrosine metabolic process (GO:0006570)4.19715733
52cellular modified amino acid catabolic process (GO:0042219)4.10104457
53ethanol oxidation (GO:0006069)4.08234997
54protein-lipid complex remodeling (GO:0034368)4.04595089
55macromolecular complex remodeling (GO:0034367)4.04595089
56plasma lipoprotein particle remodeling (GO:0034369)4.04595089
57regulation of bile acid biosynthetic process (GO:0070857)4.03281900
58cellular amino acid catabolic process (GO:0009063)4.01699753
59bile acid and bile salt transport (GO:0015721)4.01123267
60phospholipid efflux (GO:0033700)4.00696409
61glycine metabolic process (GO:0006544)4.00313852
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.99154208
63glutamate metabolic process (GO:0006536)3.94861015
64regulation of cholesterol esterification (GO:0010872)3.93836198
65indolalkylamine metabolic process (GO:0006586)3.92903138
66regulation of cholesterol homeostasis (GO:2000188)3.87890497
67neuron cell-cell adhesion (GO:0007158)3.87552802
68serine family amino acid metabolic process (GO:0009069)3.86079829
69substrate-independent telencephalic tangential migration (GO:0021826)3.85699120
70substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.85699120
71dicarboxylic acid biosynthetic process (GO:0043650)3.83784955
72plasma lipoprotein particle clearance (GO:0034381)3.82881394
73valine metabolic process (GO:0006573)3.81334925
74presynaptic membrane organization (GO:0097090)3.79913957
752-oxoglutarate metabolic process (GO:0006103)3.73085384
76benzene-containing compound metabolic process (GO:0042537)3.70501645
77complement activation, classical pathway (GO:0006958)3.69225897
78positive regulation of fatty acid beta-oxidation (GO:0032000)3.68055710
79cellular glucuronidation (GO:0052695)3.67815004
80protein-cofactor linkage (GO:0018065)3.66701414
81phospholipid homeostasis (GO:0055091)3.66697079
82positive regulation of mitochondrial fission (GO:0090141)3.65761893
83cellular ketone body metabolic process (GO:0046950)3.65237546
84nonmotile primary cilium assembly (GO:0035058)3.63904754
85cholesterol efflux (GO:0033344)3.63521934
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.63450674
87serine family amino acid biosynthetic process (GO:0009070)3.60330266
88organic acid catabolic process (GO:0016054)3.56687391
89carboxylic acid catabolic process (GO:0046395)3.56687391
90positive regulation of lipid catabolic process (GO:0050996)3.56165444
91short-chain fatty acid metabolic process (GO:0046459)3.55570533
92epithelial cilium movement (GO:0003351)3.55433509
93acetyl-CoA metabolic process (GO:0006084)3.55383948
94amine catabolic process (GO:0009310)3.54658768
95cellular biogenic amine catabolic process (GO:0042402)3.54658768
96drug catabolic process (GO:0042737)3.54060225
97postsynaptic membrane organization (GO:0001941)3.53616283
98complement activation (GO:0006956)3.53243631
99cytolysis (GO:0019835)3.52703677
100drug transmembrane transport (GO:0006855)3.52598776
101fatty acid beta-oxidation (GO:0006635)3.51560307
102intestinal cholesterol absorption (GO:0030299)3.48641293
103arginine metabolic process (GO:0006525)3.48134840
104fatty acid oxidation (GO:0019395)3.46524542
105cholesterol homeostasis (GO:0042632)3.46010041
106protein localization to cilium (GO:0061512)3.45809898
107monocarboxylic acid catabolic process (GO:0072329)3.42701863
108plasma lipoprotein particle assembly (GO:0034377)3.42112828
109regulation of fatty acid beta-oxidation (GO:0031998)3.41684957
110aspartate family amino acid catabolic process (GO:0009068)3.41268456
111sterol homeostasis (GO:0055092)3.41057780
112fatty acid catabolic process (GO:0009062)3.39672824
113lipid oxidation (GO:0034440)3.38232227
114retinal cone cell development (GO:0046549)3.36581269
115protein activation cascade (GO:0072376)3.29878193
116cilium morphogenesis (GO:0060271)3.27796268
117glucuronate metabolic process (GO:0019585)3.27761671
118uronic acid metabolic process (GO:0006063)3.27761671
119negative regulation of oligodendrocyte differentiation (GO:0048715)3.27744402
120fibrinolysis (GO:0042730)3.26708188
121positive regulation of lipoprotein lipase activity (GO:0051006)3.26250669
122fucose catabolic process (GO:0019317)3.22421905
123L-fucose metabolic process (GO:0042354)3.22421905
124L-fucose catabolic process (GO:0042355)3.22421905
125protein polyglutamylation (GO:0018095)3.22359717
126vocalization behavior (GO:0071625)3.22269310
127kidney morphogenesis (GO:0060993)3.21530559
128calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.17299807
129neural tube formation (GO:0001841)3.15886467
130regulation of cilium movement (GO:0003352)3.09448786
131negative regulation of telomere maintenance (GO:0032205)3.08150836
132negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04968558
133head development (GO:0060322)3.01592773
134behavioral response to ethanol (GO:0048149)2.99939197
135regulation of feeding behavior (GO:0060259)2.98510353
136cilium movement (GO:0003341)2.93554640
137synapse assembly (GO:0007416)2.93413946
138olfactory bulb development (GO:0021772)2.90469863
139limb bud formation (GO:0060174)2.88437092
140axoneme assembly (GO:0035082)2.86150715
141water-soluble vitamin biosynthetic process (GO:0042364)2.85344263
142inositol phosphate catabolic process (GO:0071545)2.84487077
143detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83944822
144intraciliary transport (GO:0042073)2.83781932
145retinal ganglion cell axon guidance (GO:0031290)2.82459839
146G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81053894
147synaptic transmission, cholinergic (GO:0007271)2.80849683
148protein neddylation (GO:0045116)2.79774552
149cilium organization (GO:0044782)2.78528049
150cerebral cortex radially oriented cell migration (GO:0021799)2.78138699
151cilium assembly (GO:0042384)2.72056855
152somite development (GO:0061053)2.70935764
153auditory behavior (GO:0031223)2.70754408
154regulation of development, heterochronic (GO:0040034)2.70336902
155dendritic spine morphogenesis (GO:0060997)2.66448412
156reflex (GO:0060004)2.66049951
157glycosphingolipid biosynthetic process (GO:0006688)2.66044696
158adaptation of signaling pathway (GO:0023058)2.65846373
159positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.61778120
160mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.61778120
161regulation of collateral sprouting (GO:0048670)2.61423717
162S-adenosylmethionine metabolic process (GO:0046500)2.61214157
163photoreceptor cell maintenance (GO:0045494)2.61055584
164GPI anchor metabolic process (GO:0006505)2.60736694
165L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.59764228
166C4-dicarboxylate transport (GO:0015740)2.59734446
167detection of light stimulus involved in sensory perception (GO:0050962)2.59513732
168detection of light stimulus involved in visual perception (GO:0050908)2.59513732
169positive regulation of synapse assembly (GO:0051965)2.58793549
170regulation of oligodendrocyte differentiation (GO:0048713)2.58360431
171ubiquinone metabolic process (GO:0006743)2.57660996
172preassembly of GPI anchor in ER membrane (GO:0016254)2.57181748
173negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.56459476
174negative regulation of translation, ncRNA-mediated (GO:0040033)2.56459476
175regulation of translation, ncRNA-mediated (GO:0045974)2.56459476
176negative regulation of transcription regulatory region DNA binding (GO:2000678)2.56454413
177ketone body metabolic process (GO:1902224)2.56240952
178pyrimidine dimer repair (GO:0006290)2.56196665
179amino acid salvage (GO:0043102)2.55840547
180L-methionine salvage (GO:0071267)2.55840547
181L-methionine biosynthetic process (GO:0071265)2.55840547
182regulation of telomere maintenance (GO:0032204)2.55176248
183platelet dense granule organization (GO:0060155)2.54940010
184ubiquinone biosynthetic process (GO:0006744)2.53995635
185mechanosensory behavior (GO:0007638)2.53937651
186mitochondrial respiratory chain complex I assembly (GO:0032981)2.53609917
187NADH dehydrogenase complex assembly (GO:0010257)2.53609917
188mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.53609917
189photoreceptor cell development (GO:0042461)2.52204815
190protein complex biogenesis (GO:0070271)2.49449007
191cell differentiation in spinal cord (GO:0021515)2.49245458
192smoothened signaling pathway (GO:0007224)2.46756342
193negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46086777
194transmission of nerve impulse (GO:0019226)2.44612736
195negative regulation of glial cell differentiation (GO:0045686)2.44048529
196polyol catabolic process (GO:0046174)2.42485384
197positive regulation of oligodendrocyte differentiation (GO:0048714)2.42042656
198piRNA metabolic process (GO:0034587)2.41716671
199protein localization to synapse (GO:0035418)2.41655187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.57398183
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.74114893
3LXR_22158963_ChIP-Seq_LIVER_Mouse6.01285262
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.83130808
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.82065013
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.44346644
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.14665678
8ZNF274_21170338_ChIP-Seq_K562_Hela3.87222976
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.68571015
10IGF1R_20145208_ChIP-Seq_DFB_Human3.30294060
11GBX2_23144817_ChIP-Seq_PC3_Human3.21835692
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.19943127
13EZH2_22144423_ChIP-Seq_EOC_Human3.11167671
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.72057651
15VDR_22108803_ChIP-Seq_LS180_Human2.55467992
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52245161
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43756825
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37309549
19EWS_26573619_Chip-Seq_HEK293_Human2.35301616
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26460164
21FUS_26573619_Chip-Seq_HEK293_Human2.25689180
22P300_19829295_ChIP-Seq_ESCs_Human2.19104008
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16498941
24CLOCK_20551151_ChIP-Seq_293T_Human2.14225767
25TAF15_26573619_Chip-Seq_HEK293_Human2.12111419
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07480171
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03206081
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00872354
29RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00864452
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6002721
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99202183
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90461626
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.82957377
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.81579157
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.81294582
36GATA1_22025678_ChIP-Seq_K562_Human1.77672198
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77504128
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.69560592
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.69331309
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.65145282
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63139666
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62872022
43CBP_20019798_ChIP-Seq_JUKART_Human1.60577453
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60577453
45SMAD4_21799915_ChIP-Seq_A2780_Human1.54400532
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54242413
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54059840
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53333000
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.52152347
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51458262
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51188385
52ER_23166858_ChIP-Seq_MCF-7_Human1.50798559
53REST_21632747_ChIP-Seq_MESCs_Mouse1.50471315
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49272088
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48181356
56RNF2_27304074_Chip-Seq_NSC_Mouse1.46868326
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46659399
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46365630
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.45582896
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45170101
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44424061
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42940698
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42940698
64SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42679374
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41478064
66HNF4A_19822575_ChIP-Seq_HepG2_Human1.41147646
67AR_25329375_ChIP-Seq_VCAP_Human1.39513298
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39493019
69STAT3_23295773_ChIP-Seq_U87_Human1.39403405
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38515025
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38458075
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37563502
73TP53_22573176_ChIP-Seq_HFKS_Human1.37399343
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.36816363
75IRF1_19129219_ChIP-ChIP_H3396_Human1.35479458
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33022858
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32619051
78TCF4_23295773_ChIP-Seq_U87_Human1.31323670
79NANOG_19829295_ChIP-Seq_ESCs_Human1.29102553
80SOX2_19829295_ChIP-Seq_ESCs_Human1.29102553
81EZH2_27304074_Chip-Seq_ESCs_Mouse1.26324510
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26281654
83RUNX2_22187159_ChIP-Seq_PCA_Human1.25690057
84SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25563469
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25438629
86GABP_17652178_ChIP-ChIP_JURKAT_Human1.24010394
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23932736
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.23882798
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22958795
90MYC_18940864_ChIP-ChIP_HL60_Human1.22798261
91REST_18959480_ChIP-ChIP_MESCs_Mouse1.22145418
92EED_16625203_ChIP-ChIP_MESCs_Mouse1.21012751
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.20721061
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16913699
95FOXO3_23340844_ChIP-Seq_DLD1_Human1.16699416
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16599262
97ELK1_19687146_ChIP-ChIP_HELA_Human1.16026001
98EST1_17652178_ChIP-ChIP_JURKAT_Human1.15865960
99RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15305174
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14928406
101TCF4_22108803_ChIP-Seq_LS180_Human1.13430441
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12798945
103ZNF263_19887448_ChIP-Seq_K562_Human1.11955417
104GATA4_25053715_ChIP-Seq_YYC3_Human1.11810546
105SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11607365
106JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11112313
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10302844
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10182073
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09813686
110TAL1_26923725_Chip-Seq_HPCs_Mouse1.06950491
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06510430
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.05463152
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05352443
114EZH2_27294783_Chip-Seq_NPCs_Mouse1.04621802
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03794629
116P53_22387025_ChIP-Seq_ESCs_Mouse1.03565364
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03394684
118AR_21572438_ChIP-Seq_LNCaP_Human1.02776999
119SOX2_16153702_ChIP-ChIP_HESCs_Human1.02519260
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02202304
121SMAD4_21741376_ChIP-Seq_EPCs_Human1.01593454
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00515952
123SOX2_21211035_ChIP-Seq_LN229_Gbm1.00182762
124ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99673310
125FLI1_21867929_ChIP-Seq_TH2_Mouse0.99664719
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99476526
127FOXA1_25329375_ChIP-Seq_VCAP_Human0.98989554
128FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98989554
129ESR2_21235772_ChIP-Seq_MCF-7_Human0.97768747
130BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97234433
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96779265
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94474123
133RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93212457
134CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93153533
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92739815
136SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90111106
137HTT_18923047_ChIP-ChIP_STHdh_Human0.89435955
138ESR1_21235772_ChIP-Seq_MCF-7_Human0.88243090
139FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82494819
140GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82157367
141RARA_24833708_ChIP-Seq_LIVER_Mouse0.81803341
142LXR_22292898_ChIP-Seq_THP-1_Human0.80444201
143GATA6_25053715_ChIP-Seq_YYC3_Human0.79554156
144GATA1_19941826_ChIP-Seq_K562_Human0.77267009
145TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.77248209
146BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77186680
147TBX20_22080862_ChIP-Seq_HEART_Mouse0.76087464
148TBX20_22328084_ChIP-Seq_HEART_Mouse0.76087464
149FOXA1_25552417_ChIP-Seq_VCAP_Human0.75571983
150RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.74761631
151PPAR_26484153_Chip-Seq_NCI-H1993_Human0.73208820
152SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71022432
153RARB_24833708_ChIP-Seq_LIVER_Mouse0.70470927
154BCAT_22108803_ChIP-Seq_LS180_Human0.70343844
155KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.69818566
156FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.68642496
157AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68267273
158EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.66787025
159NFIB_24661679_ChIP-Seq_LUNG_Mouse0.65854767
160SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65640724
161TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65333060
162BRD4_27068464_Chip-Seq_AML-cells_Mouse0.64022843
163KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.63521317
164Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.63244384
165MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.62785906
166ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62721978
167CEBPB_22108803_ChIP-Seq_LS180_Human0.62317222
168GATA2_19941826_ChIP-Seq_K562_Human0.62097389
169NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60457941
170PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.60180332
171TCF7_22412390_ChIP-Seq_EML_Mouse0.59539140
172GATA3_24758297_ChIP-Seq_MCF-7_Human0.57449592
173ESR1_15608294_ChIP-ChIP_MCF-7_Human0.57143445
174RUNX1_27514584_Chip-Seq_MCF-7_Human0.56885442
175ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.56723676
176ESET_19884257_ChIP-Seq_ESCs_Mouse0.56083953
177E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.56033674
178ERG_20517297_ChIP-Seq_VCAP_Human0.56028677
179P53_21459846_ChIP-Seq_SAOS-2_Human0.55911715
180FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55799486
181SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.55639057
182BCOR_27268052_Chip-Seq_Bcells_Human0.54332223
183KAP1_22055183_ChIP-Seq_ESCs_Mouse0.53917376
184CDX2_22108803_ChIP-Seq_LS180_Human0.53714177
185PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.53307643
186FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.53271207
187GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.53202171
188STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52985395
189FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.52847255
190SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.51688277
191PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.51467786
192STAT1_17558387_ChIP-Seq_HELA_Human0.51420262
193LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.50963411
194KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.50647276
195NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.49955706
196PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.49688006
197CBP_21632823_ChIP-Seq_H3396_Human0.48807885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.50893443
2MP0005360_urolithiasis6.73779374
3MP0005365_abnormal_bile_salt6.01985012
4MP0005085_abnormal_gallbladder_physiolo5.84536531
5MP0008875_abnormal_xenobiotic_pharmacok4.36863355
6MP0003252_abnormal_bile_duct4.13674914
7MP0003806_abnormal_nucleotide_metabolis3.65330454
8MP0010329_abnormal_lipoprotein_level3.29615535
9MP0002102_abnormal_ear_morphology2.93518991
10MP0001666_abnormal_nutrient_absorption2.85479160
11MP0003880_abnormal_central_pattern2.85356044
12MP0005083_abnormal_biliary_tract2.75000732
13MP0001984_abnormal_olfaction2.65643951
14MP0009840_abnormal_foam_cell2.64535995
15MP0003122_maternal_imprinting2.63115451
16MP0003195_calcinosis2.62305398
17MP0005332_abnormal_amino_acid2.53971536
18MP0008877_abnormal_DNA_methylation2.52457899
19MP0002138_abnormal_hepatobiliary_system2.40855279
20MP0001529_abnormal_vocalization2.33762829
21MP0002822_catalepsy2.32408551
22MP0003787_abnormal_imprinting2.25398323
23MP0000609_abnormal_liver_physiology2.23044585
24MP0003136_yellow_coat_color2.16919130
25MP0003868_abnormal_feces_composition2.11977969
26MP0005645_abnormal_hypothalamus_physiol2.11681162
27MP0006292_abnormal_olfactory_placode2.10152953
28MP0006072_abnormal_retinal_apoptosis2.06491523
29MP0006276_abnormal_autonomic_nervous2.05407578
30MP0008789_abnormal_olfactory_epithelium2.03335472
31MP0002118_abnormal_lipid_homeostasis2.02764450
32MP0002638_abnormal_pupillary_reflex2.01130206
33MP0003121_genomic_imprinting1.92968043
34MP0005253_abnormal_eye_physiology1.92732526
35MP0005551_abnormal_eye_electrophysiolog1.92517413
36MP0001986_abnormal_taste_sensitivity1.89875070
37MP0003191_abnormal_cellular_cholesterol1.89141618
38MP0005394_taste/olfaction_phenotype1.87454276
39MP0005499_abnormal_olfactory_system1.87454276
40MP0009046_muscle_twitch1.84907345
41MP0004019_abnormal_vitamin_homeostasis1.84027817
42MP0009745_abnormal_behavioral_response1.82274445
43MP0000778_abnormal_nervous_system1.82059852
44MP0002653_abnormal_ependyma_morphology1.77821696
45MP0004885_abnormal_endolymph1.77425506
46MP0001968_abnormal_touch/_nociception1.77179283
47MP0000631_abnormal_neuroendocrine_gland1.75031187
48MP0005319_abnormal_enzyme/_coenzyme1.73188643
49MP0004142_abnormal_muscle_tone1.71509148
50MP0003705_abnormal_hypodermis_morpholog1.69181947
51MP0009780_abnormal_chondrocyte_physiolo1.66993053
52MP0004859_abnormal_synaptic_plasticity1.66963841
53MP0002751_abnormal_autonomic_nervous1.61223381
54MP0005647_abnormal_sex_gland1.58030620
55MP0001486_abnormal_startle_reflex1.56442433
56MP0004133_heterotaxia1.56342129
57MP0002272_abnormal_nervous_system1.53433493
58MP0005220_abnormal_exocrine_pancreas1.51633652
59MP0002837_dystrophic_cardiac_calcinosis1.51180294
60MP0000049_abnormal_middle_ear1.48826141
61MP0002736_abnormal_nociception_after1.48176905
62MP0003635_abnormal_synaptic_transmissio1.48125733
63MP0009643_abnormal_urine_homeostasis1.46051619
64MP0005584_abnormal_enzyme/coenzyme_acti1.44399298
65MP0002572_abnormal_emotion/affect_behav1.38422234
66MP0004270_analgesia1.35732572
67MP0010234_abnormal_vibrissa_follicle1.34523928
68MP0005423_abnormal_somatic_nervous1.33158451
69MP0002557_abnormal_social/conspecific_i1.32838442
70MP0002254_reproductive_system_inflammat1.32535951
71MP0002938_white_spotting1.31862915
72MP0005646_abnormal_pituitary_gland1.31319272
73MP0002184_abnormal_innervation1.30556437
74MP0005187_abnormal_penis_morphology1.30431378
75MP0000566_synostosis1.30288943
76MP0005670_abnormal_white_adipose1.29122186
77MP0002063_abnormal_learning/memory/cond1.28343007
78MP0002064_seizures1.25847221
79MP0001764_abnormal_homeostasis1.25214783
80MP0002735_abnormal_chemical_nociception1.24817205
81MP0003646_muscle_fatigue1.23617815
82MP0003890_abnormal_embryonic-extraembry1.23385977
83MP0000427_abnormal_hair_cycle1.22346576
84MP0002734_abnormal_mechanical_nocicepti1.21680164
85MP0003119_abnormal_digestive_system1.21175526
86MP0000647_abnormal_sebaceous_gland1.20278156
87MP0000598_abnormal_liver_morphology1.18795691
88MP0004924_abnormal_behavior1.18580056
89MP0005386_behavior/neurological_phenoty1.18580056
90MP0001188_hyperpigmentation1.16628593
91MP0002234_abnormal_pharynx_morphology1.16348517
92MP0001485_abnormal_pinna_reflex1.14279626
93MP0002752_abnormal_somatic_nervous1.14190661
94MP0003300_gastrointestinal_ulcer1.12684594
95MP0008995_early_reproductive_senescence1.12547629
96MP0002067_abnormal_sensory_capabilities1.10932342
97MP0000026_abnormal_inner_ear1.09865751
98MP0008872_abnormal_physiological_respon1.08062543
99MP0000685_abnormal_immune_system1.07967900
100MP0005195_abnormal_posterior_eye1.07145128
101MP0002928_abnormal_bile_duct1.06419998
102MP0004130_abnormal_muscle_cell1.05969491
103MP0001293_anophthalmia1.05147031
104MP0002882_abnormal_neuron_morphology1.02085918
105MP0004811_abnormal_neuron_physiology1.01874277
106MP0000955_abnormal_spinal_cord1.01291692
107MP0000516_abnormal_urinary_system1.01210274
108MP0005367_renal/urinary_system_phenotyp1.01210274
109MP0000372_irregular_coat_pigmentation1.01203919
110MP0005171_absent_coat_pigmentation0.98781621
111MP0002733_abnormal_thermal_nociception0.98651877
112MP0004742_abnormal_vestibular_system0.98517700
113MP0003567_abnormal_fetal_cardiomyocyte0.97633949
114MP0000604_amyloidosis0.96379471
115MP0002971_abnormal_brown_adipose0.96111547
116MP0001970_abnormal_pain_threshold0.94351208
117MP0002160_abnormal_reproductive_system0.94222893
118MP0001963_abnormal_hearing_physiology0.94106997
119MP0003011_delayed_dark_adaptation0.93797732
120MP0005391_vision/eye_phenotype0.93629457
121MP0002078_abnormal_glucose_homeostasis0.93110501
122MP0002233_abnormal_nose_morphology0.92583279
123MP0002876_abnormal_thyroid_physiology0.92437098
124MP0001502_abnormal_circadian_rhythm0.92104002
125MP0009763_increased_sensitivity_to0.91494221
126MP0005451_abnormal_body_composition0.91285247
127MP0001905_abnormal_dopamine_level0.90415848
128MP0008058_abnormal_DNA_repair0.89371472
129MP0001661_extended_life_span0.88952420
130MP0005636_abnormal_mineral_homeostasis0.88937950
131MP0010386_abnormal_urinary_bladder0.88706882
132MP0005666_abnormal_adipose_tissue0.87895435
133MP0003937_abnormal_limbs/digits/tail_de0.87317172
134MP0003718_maternal_effect0.86885085
135MP0005410_abnormal_fertilization0.86677961
136MP0005334_abnormal_fat_pad0.86029139
137MP0003938_abnormal_ear_development0.85973339
138MP0002909_abnormal_adrenal_gland0.85678813
139MP0008469_abnormal_protein_level0.85290981
140MP0001270_distended_abdomen0.85100688
141MP0009642_abnormal_blood_homeostasis0.84623370
142MP0003283_abnormal_digestive_organ0.83946615
143MP0001501_abnormal_sleep_pattern0.82652888
144MP0009765_abnormal_xenobiotic_induced0.78240042
145MP0003186_abnormal_redox_activity0.77724685
146MP0009764_decreased_sensitivity_to0.74413635
147MP0003183_abnormal_peptide_metabolism0.73405852
148MP0003656_abnormal_erythrocyte_physiolo0.70893354
149MP0001944_abnormal_pancreas_morphology0.70034721
150MP0010368_abnormal_lymphatic_system0.69124547
151MP0001756_abnormal_urination0.69031820
152MP0005084_abnormal_gallbladder_morpholo0.68180971
153MP0004264_abnormal_extraembryonic_tissu0.67806925
154MP0009053_abnormal_anal_canal0.66945630
155MP0002136_abnormal_kidney_physiology0.65175909
156MP0002166_altered_tumor_susceptibility0.64263100
157MP0009697_abnormal_copulation0.63204623
158MP0008961_abnormal_basal_metabolism0.59999727
159MP0005408_hypopigmentation0.58089238
160MP0003329_amyloid_beta_deposits0.57094409
161MP0005448_abnormal_energy_balance0.55855566
162MP0006036_abnormal_mitochondrial_physio0.55111413
163MP0003453_abnormal_keratinocyte_physiol0.55057785
164MP0005535_abnormal_body_temperature0.54485717
165MP0005376_homeostasis/metabolism_phenot0.53908911
166MP0009384_cardiac_valve_regurgitation0.52776809
167MP0005375_adipose_tissue_phenotype0.51964294
168MP0002168_other_aberrant_phenotype0.51596796
169MP0003959_abnormal_lean_body0.50352508
170MP0005248_abnormal_Harderian_gland0.50063682
171MP0009115_abnormal_fat_cell0.47214962
172MP0001873_stomach_inflammation0.46925600
173MP0001881_abnormal_mammary_gland0.46436468
174MP0001765_abnormal_ion_homeostasis0.45276130
175MP0005464_abnormal_platelet_physiology0.45213150
176MP0003953_abnormal_hormone_level0.45088779
177MP0005266_abnormal_metabolism0.43556289
178MP0002693_abnormal_pancreas_physiology0.42885849
179MP0000639_abnormal_adrenal_gland0.42658306
180MP0001845_abnormal_inflammatory_respons0.42177006
181MP0002970_abnormal_white_adipose0.41557108
182MP0002089_abnormal_postnatal_growth/wei0.40415474
183MP0003436_decreased_susceptibility_to0.39535925
184MP0000371_diluted_coat_color0.39210938
185MP0004185_abnormal_adipocyte_glucose0.38716191
186MP0009672_abnormal_birth_weight0.38482822
187MP0001853_heart_inflammation0.37259597
188MP0004043_abnormal_pH_regulation0.37227410
189MP0002269_muscular_atrophy0.37178376
190MP0004947_skin_inflammation0.37031385
191MP0002135_abnormal_kidney_morphology0.36505379
192MP0005395_other_phenotype0.33776675
193MP0003690_abnormal_glial_cell0.33375372

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.68053244
2Deep venous thrombosis (HP:0002625)6.66296593
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.43442938
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.06488887
5Xanthomatosis (HP:0000991)5.74360026
6Hypobetalipoproteinemia (HP:0003563)5.56483330
7Prolonged partial thromboplastin time (HP:0003645)5.48626177
8Complement deficiency (HP:0004431)5.15206750
9Hyperlipoproteinemia (HP:0010980)4.88198229
10Ketosis (HP:0001946)4.47383628
11Abnormality of the common coagulation pathway (HP:0010990)4.36879856
12Hyperammonemia (HP:0001987)4.34033408
13Hypolipoproteinemia (HP:0010981)4.24660086
14Epidermoid cyst (HP:0200040)4.22551331
15Pancreatic cysts (HP:0001737)4.22457610
16Hypoglycemic coma (HP:0001325)4.22321710
17Hyperglycinemia (HP:0002154)4.06995178
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.02006648
19Conjugated hyperbilirubinemia (HP:0002908)3.98447615
20Hyperglycinuria (HP:0003108)3.96777520
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.88780593
22Abnormality of complement system (HP:0005339)3.87475135
23True hermaphroditism (HP:0010459)3.87172739
24Abnormality of glycine metabolism (HP:0010895)3.86527132
25Abnormality of serine family amino acid metabolism (HP:0010894)3.86527132
26Pancreatic fibrosis (HP:0100732)3.84607613
27Fat malabsorption (HP:0002630)3.83127686
28Abnormality of the intrinsic pathway (HP:0010989)3.82933392
29Hypoalphalipoproteinemia (HP:0003233)3.80981662
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.74195634
31Molar tooth sign on MRI (HP:0002419)3.71758306
32Abnormality of midbrain morphology (HP:0002418)3.71758306
33Joint hemorrhage (HP:0005261)3.71740586
34Ketoacidosis (HP:0001993)3.54251078
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.45330494
36Abnormality of aspartate family amino acid metabolism (HP:0010899)3.45098786
37Medial flaring of the eyebrow (HP:0010747)3.41257116
38Chronic hepatic failure (HP:0100626)3.33102156
39Hypercholesterolemia (HP:0003124)3.33079505
40Abnormality of fatty-acid metabolism (HP:0004359)3.20603697
41Abnormality of methionine metabolism (HP:0010901)3.19513507
42Hyperventilation (HP:0002883)3.17524437
43Gait imbalance (HP:0002141)3.15218271
44Abnormality of pyrimidine metabolism (HP:0004353)3.14930199
45Nephronophthisis (HP:0000090)3.14829270
46Myocardial infarction (HP:0001658)3.08769476
47Congenital primary aphakia (HP:0007707)3.03037067
48Type II lissencephaly (HP:0007260)3.02996701
49Nephrogenic diabetes insipidus (HP:0009806)3.00958887
50Abnormality of nucleobase metabolism (HP:0010932)2.98238494
51Hyperbilirubinemia (HP:0002904)2.97241148
52Esophageal varix (HP:0002040)2.97197362
53Lissencephaly (HP:0001339)2.95355149
54Abnormality of purine metabolism (HP:0004352)2.89892641
55Gout (HP:0001997)2.89833640
56Hypoglycemic seizures (HP:0002173)2.89400885
57Congenital stationary night blindness (HP:0007642)2.83342831
58Hepatocellular carcinoma (HP:0001402)2.79217065
59Spastic diplegia (HP:0001264)2.78167720
60Skin nodule (HP:0200036)2.76071383
61Polyphagia (HP:0002591)2.75767170
62Abnormality of the labia minora (HP:0012880)2.75012071
63Delayed CNS myelination (HP:0002188)2.74982158
64Abnormality of the renal medulla (HP:0100957)2.73494154
65Inability to walk (HP:0002540)2.70314964
66Steatorrhea (HP:0002570)2.68760638
67Intestinal atresia (HP:0011100)2.68089986
68Hyperinsulinemic hypoglycemia (HP:0000825)2.67161405
69Genital tract atresia (HP:0001827)2.67109499
70Retinal dysplasia (HP:0007973)2.66475214
71Vaginal atresia (HP:0000148)2.62899942
72Spontaneous abortion (HP:0005268)2.62394279
73Progressive inability to walk (HP:0002505)2.58831308
74Abnormality of serum amino acid levels (HP:0003112)2.57825286
75Abnormality of the renal cortex (HP:0011035)2.57147821
76Cystic liver disease (HP:0006706)2.56809778
77Occipital encephalocele (HP:0002085)2.48812080
78Enlarged kidneys (HP:0000105)2.48037009
79Hyperglycemia (HP:0003074)2.46710046
80Colon cancer (HP:0003003)2.45139321
81Optic nerve hypoplasia (HP:0000609)2.44269429
82Late onset (HP:0003584)2.41120483
83Mitral stenosis (HP:0001718)2.39941009
84Attenuation of retinal blood vessels (HP:0007843)2.38673523
85Vascular calcification (HP:0004934)2.37606481
86Metabolic acidosis (HP:0001942)2.35495306
87Hypochromic microcytic anemia (HP:0004840)2.35367873
88Sclerocornea (HP:0000647)2.34828056
89Pachygyria (HP:0001302)2.34501253
90Anencephaly (HP:0002323)2.34399398
91Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.33548782
92Systemic lupus erythematosus (HP:0002725)2.31618820
93Acanthocytosis (HP:0001927)2.31582800
94Hypothermia (HP:0002045)2.30883573
95Broad-based gait (HP:0002136)2.30276459
96Septo-optic dysplasia (HP:0100842)2.25853773
97Abnormal rod and cone electroretinograms (HP:0008323)2.25317803
98Dicarboxylic aciduria (HP:0003215)2.24606298
99Abnormality of dicarboxylic acid metabolism (HP:0010995)2.24606298
100Thyroid-stimulating hormone excess (HP:0002925)2.20507779
101Abolished electroretinogram (ERG) (HP:0000550)2.20377146
102Sensorimotor neuropathy (HP:0007141)2.18842097
103Aplasia/Hypoplasia of the tongue (HP:0010295)2.18536533
104Postaxial foot polydactyly (HP:0001830)2.18191978
105Drooling (HP:0002307)2.17531509
106Cardiovascular calcification (HP:0011915)2.17462911
107Agitation (HP:0000713)2.15661943
108Postaxial hand polydactyly (HP:0001162)2.15036948
109Hemiparesis (HP:0001269)2.13467375
110Cortical dysplasia (HP:0002539)2.12323123
111Pancreatitis (HP:0001733)2.12284669
112Abnormality of proline metabolism (HP:0010907)2.11844273
113Hydroxyprolinuria (HP:0003080)2.11844273
114Specific learning disability (HP:0001328)2.10451472
115Methylmalonic acidemia (HP:0002912)2.08512844
116Irritability (HP:0000737)2.08477701
117Hemorrhage of the eye (HP:0011885)2.08142541
118Malnutrition (HP:0004395)2.07342047
119Neonatal onset (HP:0003623)2.07280025
120Abnormal gallbladder morphology (HP:0012437)2.06472485
121Congenital hepatic fibrosis (HP:0002612)2.04826653
122Narrow forehead (HP:0000341)2.04567205
123Dynein arm defect of respiratory motile cilia (HP:0012255)2.04303624
124Absent/shortened dynein arms (HP:0200106)2.04303624
125Methylmalonic aciduria (HP:0012120)2.03082639
126Symptomatic seizures (HP:0011145)2.03061362
127Poor coordination (HP:0002370)2.01851446
128Glomerulonephritis (HP:0000099)2.00681213
129Hypsarrhythmia (HP:0002521)1.99762752
130Oligodactyly (hands) (HP:0001180)1.98875926
131Lethargy (HP:0001254)1.98436635
132Abnormal respiratory epithelium morphology (HP:0012253)1.96448550
133Abnormal respiratory motile cilium morphology (HP:0005938)1.96448550
134Cholelithiasis (HP:0001081)1.96020597
135Excessive salivation (HP:0003781)1.94768814
136Anophthalmia (HP:0000528)1.94625209
137Thrombophlebitis (HP:0004418)1.94491019
138Recurrent gram-negative bacterial infections (HP:0005420)1.94297578
139Abnormal ciliary motility (HP:0012262)1.92721299
140Gingival bleeding (HP:0000225)1.92193519
141Back pain (HP:0003418)1.92079941
142Lipid accumulation in hepatocytes (HP:0006561)1.91787723
143Abnormal biliary tract physiology (HP:0012439)1.91341937
144Bile duct proliferation (HP:0001408)1.91341937
145Polydipsia (HP:0001959)1.91326575
146Abnormal drinking behavior (HP:0030082)1.91326575
147Absent speech (HP:0001344)1.90798167
148Large for gestational age (HP:0001520)1.90785832
149Cerebellar dysplasia (HP:0007033)1.89655126
150Generalized aminoaciduria (HP:0002909)1.88591545
151Patellar aplasia (HP:0006443)1.88481999
152Male pseudohermaphroditism (HP:0000037)1.86496137
153Acute necrotizing encephalopathy (HP:0006965)1.86274726
154Poikilocytosis (HP:0004447)1.86084504
155Aplasia/Hypoplasia of the patella (HP:0006498)1.85677943
156EEG with generalized epileptiform discharges (HP:0011198)1.85473786
157Cholecystitis (HP:0001082)1.85341810
158Abnormal gallbladder physiology (HP:0012438)1.85341810
159Polyuria (HP:0000103)1.85256883
160Upper motor neuron abnormality (HP:0002127)1.85122241
161Tubulointerstitial nephritis (HP:0001970)1.84087643
1623-Methylglutaconic aciduria (HP:0003535)1.81685324
163Dandy-Walker malformation (HP:0001305)1.80810657
164Mitochondrial inheritance (HP:0001427)1.80048968
165Hyperuricemia (HP:0002149)1.79835305
166Increased purine levels (HP:0004368)1.79835305
167Epileptiform EEG discharges (HP:0011182)1.79788379
168Aplasia/Hypoplasia of the tibia (HP:0005772)1.77008247
169Abnormality of the pancreatic islet cells (HP:0006476)1.76725964
170Abnormality of endocrine pancreas physiology (HP:0012093)1.76725964
171Abnormal cartilage morphology (HP:0002763)1.76672476
172Abnormal enzyme/coenzyme activity (HP:0012379)1.75948815
173Focal motor seizures (HP:0011153)1.75709030
174Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75274765
175Hypoplasia of the brainstem (HP:0002365)1.75274765
176Preaxial hand polydactyly (HP:0001177)1.74989210
177Pendular nystagmus (HP:0012043)1.74748465
178Abnormality of the gallbladder (HP:0005264)1.74628904
179Protuberant abdomen (HP:0001538)1.74462646
180Progressive macrocephaly (HP:0004481)1.73330565
181Limb dystonia (HP:0002451)1.73149536
182Polymicrogyria (HP:0002126)1.73065657
183Gaze-evoked nystagmus (HP:0000640)1.72901932
184Decreased testicular size (HP:0008734)1.72585191
185Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72367474
186Abnormality of the lumbar spine (HP:0100712)1.72327178
187Acute encephalopathy (HP:0006846)1.72153896
188Broad foot (HP:0001769)1.72110499
189Abnormality of the lower motor neuron (HP:0002366)1.72021373
190Myoglobinuria (HP:0002913)1.71869133
191Prominent nasal bridge (HP:0000426)1.71713780
192Renal cortical cysts (HP:0000803)1.71288020
193Stroke (HP:0001297)1.71254957
194Menorrhagia (HP:0000132)1.71012197
195Elevated hepatic transaminases (HP:0002910)1.70655830
196Brushfield spots (HP:0001088)1.70626478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.96030865
2BCKDK4.48923196
3ERN14.13067479
4SIK13.56093349
5TRIB33.35518082
6FGFR43.31867258
7PDK32.92350449
8PDK42.92350449
9MAP3K42.92290876
10PKN22.67458867
11WNK32.65949326
12FGFR32.65786307
13CASK2.65187976
14MARK12.54246527
15MAP2K72.50063144
16INSRR2.44581844
17FRK2.39383106
18TRIM282.35925016
19BMPR1B2.26816393
20TAOK32.24105527
21PTK62.18552930
22BCR2.18232618
23FLT32.10910221
24PINK12.06554908
25DYRK21.93123577
26ADRBK21.90572836
27ZAK1.89468522
28TNIK1.88995484
29TYK21.83407889
30LATS11.80262218
31DYRK1B1.78986245
32MAPK131.72455919
33CSNK1G31.71778843
34CSNK1G21.70743670
35MAPK151.67145346
36MAP3K101.65560207
37CSNK1A1L1.62972803
38CSNK1G11.62715958
39CDK191.59382227
40MAP3K71.57429522
41PDK21.54099496
42GRK11.52402850
43EEF2K1.46651472
44NEK91.43101371
45NTRK21.42423353
46JAK11.41513967
47ERBB41.38776871
48CAMK1D1.27593476
49MAPK111.21514919
50PIK3CG1.19561477
51FGFR21.17821020
52RIPK11.13864292
53VRK11.12118007
54JAK21.11808487
55PDGFRA1.10670068
56PRKAA21.09027629
57PRKCG1.07172193
58RPS6KA41.06850200
59EPHA41.05319958
60GRK61.04999949
61ERBB31.04632755
62MST1R1.04558589
63TBK11.03402661
64FGFR11.02306996
65MKNK20.99020508
66STK160.96555920
67MAP3K140.95016063
68STK38L0.94990991
69MTOR0.93998014
70PRKCE0.93696510
71CAMK1G0.93470307
72MAP4K10.90251765
73EPHB10.86771193
74TLK10.84697310
75CDK60.84633747
76JAK30.84510430
77PRKCZ0.83324525
78MKNK10.82967202
79ICK0.82441973
80MAP3K20.82176876
81DYRK1A0.81266273
82PLK20.80764934
83ADRBK10.80742156
84OXSR10.80563333
85CSF1R0.80082300
86CSK0.78752195
87TGFBR20.75422632
88DYRK30.74983788
89PAK60.74313896
90PRKAA10.74218990
91PNCK0.73593604
92RET0.72410507
93LRRK20.71927140
94ITK0.71148906
95PTK20.66348164
96STK390.65719754
97PLK30.65448589
98TTN0.65425795
99PLK40.62425939
100EPHA30.61924257
101TAF10.60968305
102ZAP700.60315524
103NEK20.58968137
104WNK40.58882843
105GSK3A0.58424181
106SCYL20.57776184
107PHKG10.57509931
108PHKG20.57509931
109OBSCN0.57164406
110ERBB20.56845918
111PKN10.56782088
112MET0.56243134
113KDR0.53790687
114TGFBR10.53291954
115MELK0.53285467
116IGF1R0.53072014
117STK100.51926999
118IKBKE0.51840925
119CHUK0.51562752
120CDK40.51406209
121CCNB10.51312834
122RPS6KA50.51017480
123MINK10.50263222
124CAMKK20.50105079
125PDK10.49231026
126CSNK1A10.49180950
127STK30.49124487
128SRPK10.48805846
129CAMK2A0.48669933
130MAP2K40.47629715
131PASK0.47587734
132TSSK60.47193565
133KSR10.46090486
134PRKACG0.45300347
135NTRK30.45068707
136SIK20.44652072
137IRAK10.44491982
138STK110.43206784
139PDGFRB0.43055768
140MAPKAPK30.42317171
141CDK120.42316312
142NUAK10.42196099
143CDK50.42187860
144CDK30.41928874
145PRKD30.41751451
146CAMK10.40919968
147CSNK1D0.40170903
148CAMK40.39884416
149BTK0.39384741
150PRKCQ0.39273311
151UHMK10.39263549
152PRKACA0.39232616
153PAK20.38842440
154SGK2230.38691755
155SGK4940.38691755
156PRKACB0.38598751
157TXK0.37999836
158SGK30.37940580
159EGFR0.37439070
160GRK70.36713109
161ACVR1B0.36386215
162DAPK20.35316102
163PIK3CA0.35192017
164PRKCH0.34507078
165EPHA20.33604014
166MAP3K130.32780595
167PDPK10.32151132
168PRKG10.30440190
169PAK30.30293178
170NLK0.29699594
171CDK90.28365898
172MAP2K20.28257840
173PTK2B0.28061067
174MAPK40.27611293
175PLK10.27375636
176WEE10.25922079
177MAP3K30.25341296

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.35215707
2Nitrogen metabolism_Homo sapiens_hsa009103.72921810
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39443271
4Nicotine addiction_Homo sapiens_hsa050333.21201971
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18620132
6Arginine biosynthesis_Homo sapiens_hsa002202.87580490
7Phototransduction_Homo sapiens_hsa047442.74670802
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.74378651
9Tryptophan metabolism_Homo sapiens_hsa003802.70364145
10Fatty acid degradation_Homo sapiens_hsa000712.68734925
11Complement and coagulation cascades_Homo sapiens_hsa046102.55775445
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.49831277
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45347976
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.40174865
15Oxidative phosphorylation_Homo sapiens_hsa001902.33232494
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26142326
17Propanoate metabolism_Homo sapiens_hsa006402.14659063
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13601887
19Protein export_Homo sapiens_hsa030602.11865496
20Selenocompound metabolism_Homo sapiens_hsa004502.02137370
21Butanoate metabolism_Homo sapiens_hsa006501.99340242
22PPAR signaling pathway_Homo sapiens_hsa033201.99182048
23Fatty acid metabolism_Homo sapiens_hsa012121.92889731
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92368087
25Peroxisome_Homo sapiens_hsa041461.92057656
26Taste transduction_Homo sapiens_hsa047421.90541658
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88605166
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85039283
29Fanconi anemia pathway_Homo sapiens_hsa034601.80613980
30Caffeine metabolism_Homo sapiens_hsa002321.79544790
31Histidine metabolism_Homo sapiens_hsa003401.78671088
32GABAergic synapse_Homo sapiens_hsa047271.77884911
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.74756867
34Parkinsons disease_Homo sapiens_hsa050121.74669873
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74453487
36Morphine addiction_Homo sapiens_hsa050321.73923601
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.73246968
38Chemical carcinogenesis_Homo sapiens_hsa052041.71261106
39RNA polymerase_Homo sapiens_hsa030201.66301412
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64966317
41Basal transcription factors_Homo sapiens_hsa030221.64875802
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64804383
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.62039097
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60011004
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57239572
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.57202345
47Staphylococcus aureus infection_Homo sapiens_hsa051501.55706073
48Pyruvate metabolism_Homo sapiens_hsa006201.55141427
49ABC transporters_Homo sapiens_hsa020101.50904853
50Bile secretion_Homo sapiens_hsa049761.50425668
51Collecting duct acid secretion_Homo sapiens_hsa049661.49445199
52beta-Alanine metabolism_Homo sapiens_hsa004101.49241894
53Sulfur metabolism_Homo sapiens_hsa009201.49153115
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43678406
55Retinol metabolism_Homo sapiens_hsa008301.43550643
56RNA degradation_Homo sapiens_hsa030181.43291730
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40796510
58Fat digestion and absorption_Homo sapiens_hsa049751.37820860
59Phenylalanine metabolism_Homo sapiens_hsa003601.37772914
60Ether lipid metabolism_Homo sapiens_hsa005651.35905042
61Cardiac muscle contraction_Homo sapiens_hsa042601.31814068
62Glutamatergic synapse_Homo sapiens_hsa047241.30865959
63Starch and sucrose metabolism_Homo sapiens_hsa005001.25905349
64Olfactory transduction_Homo sapiens_hsa047401.24576927
65Huntingtons disease_Homo sapiens_hsa050161.24389403
66Circadian entrainment_Homo sapiens_hsa047131.22149660
67Cysteine and methionine metabolism_Homo sapiens_hsa002701.21048212
68Carbon metabolism_Homo sapiens_hsa012001.19906805
69Biosynthesis of amino acids_Homo sapiens_hsa012301.19730289
70Tyrosine metabolism_Homo sapiens_hsa003501.18965188
71Vitamin B6 metabolism_Homo sapiens_hsa007501.11480648
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05281126
73Homologous recombination_Homo sapiens_hsa034401.04014950
74Glycerolipid metabolism_Homo sapiens_hsa005611.03875745
75Alzheimers disease_Homo sapiens_hsa050101.03428467
76Insulin secretion_Homo sapiens_hsa049111.01487985
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01064202
78Lysine degradation_Homo sapiens_hsa003101.01018826
79Folate biosynthesis_Homo sapiens_hsa007901.00886723
80Serotonergic synapse_Homo sapiens_hsa047261.00165183
81Circadian rhythm_Homo sapiens_hsa047100.99903727
82Regulation of autophagy_Homo sapiens_hsa041400.99651277
83Dopaminergic synapse_Homo sapiens_hsa047280.99366077
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.97747844
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95933742
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95593408
87Fatty acid elongation_Homo sapiens_hsa000620.94634069
88Synaptic vesicle cycle_Homo sapiens_hsa047210.91700468
89Cocaine addiction_Homo sapiens_hsa050300.82645354
90Sulfur relay system_Homo sapiens_hsa041220.80918712
91Fatty acid biosynthesis_Homo sapiens_hsa000610.76735382
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76247463
93Axon guidance_Homo sapiens_hsa043600.76242872
94Pentose phosphate pathway_Homo sapiens_hsa000300.76195439
95Vitamin digestion and absorption_Homo sapiens_hsa049770.74661542
96Arginine and proline metabolism_Homo sapiens_hsa003300.74208004
97Non-homologous end-joining_Homo sapiens_hsa034500.72672683
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71262279
99Long-term depression_Homo sapiens_hsa047300.71055124
100Hedgehog signaling pathway_Homo sapiens_hsa043400.68311582
101One carbon pool by folate_Homo sapiens_hsa006700.66273967
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65478303
103Steroid biosynthesis_Homo sapiens_hsa001000.64094290
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63639462
105Amphetamine addiction_Homo sapiens_hsa050310.63226784
106Alcoholism_Homo sapiens_hsa050340.61878441
107Purine metabolism_Homo sapiens_hsa002300.61705891
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60877912
109Salivary secretion_Homo sapiens_hsa049700.60128559
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58968489
111Insulin resistance_Homo sapiens_hsa049310.58629576
112Prion diseases_Homo sapiens_hsa050200.55759481
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.52046778
114Arachidonic acid metabolism_Homo sapiens_hsa005900.51471898
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51356110
116Ovarian steroidogenesis_Homo sapiens_hsa049130.50655009
117Glucagon signaling pathway_Homo sapiens_hsa049220.50360709
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48790788
119Glutathione metabolism_Homo sapiens_hsa004800.46238715
120Basal cell carcinoma_Homo sapiens_hsa052170.45723072
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42886659
122Type I diabetes mellitus_Homo sapiens_hsa049400.42884174
123Fructose and mannose metabolism_Homo sapiens_hsa000510.42294558
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41933096
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41036621
126Hippo signaling pathway_Homo sapiens_hsa043900.40953180
127Calcium signaling pathway_Homo sapiens_hsa040200.40592064
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39773660
129Gap junction_Homo sapiens_hsa045400.35564954
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35561767
131Cholinergic synapse_Homo sapiens_hsa047250.35435739
132AMPK signaling pathway_Homo sapiens_hsa041520.32319971
133Renin secretion_Homo sapiens_hsa049240.31940732
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.31243676
135Metabolic pathways_Homo sapiens_hsa011000.31164328
136cAMP signaling pathway_Homo sapiens_hsa040240.30193003
137Linoleic acid metabolism_Homo sapiens_hsa005910.30097422
138RNA transport_Homo sapiens_hsa030130.29935823
139Base excision repair_Homo sapiens_hsa034100.29680638
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28890186
141Oxytocin signaling pathway_Homo sapiens_hsa049210.28323986
142Galactose metabolism_Homo sapiens_hsa000520.22027235
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.17166119
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.14165381
145Insulin signaling pathway_Homo sapiens_hsa049100.12995014
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09739232
147Dorso-ventral axis formation_Homo sapiens_hsa043200.09621435
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.07033406
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.02664065
150Prolactin signaling pathway_Homo sapiens_hsa04917-0.1453130
151Hepatitis C_Homo sapiens_hsa05160-0.1352809
152Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1318241
153Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1170501
154Notch signaling pathway_Homo sapiens_hsa04330-0.1142740
155mTOR signaling pathway_Homo sapiens_hsa04150-0.1039777
156Antigen processing and presentation_Homo sapiens_hsa04612-0.0912033
157Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0738128
158N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0515291
159Protein digestion and absorption_Homo sapiens_hsa04974-0.0448610
160Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0301298
161Bladder cancer_Homo sapiens_hsa05219-0.0212025
162Type II diabetes mellitus_Homo sapiens_hsa04930-0.0201290
163Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0100322

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