ZMAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing Cys2-His2 (C2H2)-type zinc fingers, which are similar to those found in the nuclear matrix protein matrin 3. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.47110866
2cilium or flagellum-dependent cell motility (GO:0001539)4.62760113
3epithelial cilium movement (GO:0003351)4.61202913
4axoneme assembly (GO:0035082)4.55265118
5cilium movement (GO:0003341)4.42458112
6regulation of cilium movement (GO:0003352)4.42027012
7axonemal dynein complex assembly (GO:0070286)4.27819773
8presynaptic membrane assembly (GO:0097105)4.18228231
9negative regulation of synaptic transmission, GABAergic (GO:0032229)4.10368008
10superoxide anion generation (GO:0042554)3.97298161
11presynaptic membrane organization (GO:0097090)3.93292048
12pyrimidine nucleobase catabolic process (GO:0006208)3.86955505
13regulation of microtubule-based movement (GO:0060632)3.75602341
14startle response (GO:0001964)3.50941368
15righting reflex (GO:0060013)3.50629776
16gamma-aminobutyric acid transport (GO:0015812)3.40797047
17long-chain fatty acid biosynthetic process (GO:0042759)3.40262550
18axon ensheathment in central nervous system (GO:0032291)3.39167476
19central nervous system myelination (GO:0022010)3.39167476
20head development (GO:0060322)3.34670586
21auditory behavior (GO:0031223)3.32386574
22cerebral cortex radially oriented cell migration (GO:0021799)3.30014531
23neuron cell-cell adhesion (GO:0007158)3.29913497
24neuron fate determination (GO:0048664)3.29157229
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.23927385
26activated T cell proliferation (GO:0050798)3.22887507
27interkinetic nuclear migration (GO:0022027)3.14971845
28mechanosensory behavior (GO:0007638)3.13901820
29regulation of pigment cell differentiation (GO:0050932)3.09863043
30histone H3-K4 trimethylation (GO:0080182)3.08587404
31nucleobase catabolic process (GO:0046113)3.08091307
32postsynaptic membrane organization (GO:0001941)3.07162838
33inner ear receptor cell differentiation (GO:0060113)3.05125516
34negative regulation of astrocyte differentiation (GO:0048712)3.03772785
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.01730419
36centriole assembly (GO:0098534)3.00962627
37gamma-aminobutyric acid signaling pathway (GO:0007214)3.00467941
38tongue development (GO:0043586)2.99599007
39proline transport (GO:0015824)2.97884565
40ionotropic glutamate receptor signaling pathway (GO:0035235)2.93325855
41response to pheromone (GO:0019236)2.92671022
42positive regulation of action potential (GO:0045760)2.92639664
43detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.92576804
44cell proliferation in forebrain (GO:0021846)2.89486300
45response to auditory stimulus (GO:0010996)2.87168968
46lymphoid progenitor cell differentiation (GO:0002320)2.84787681
47cyclic nucleotide catabolic process (GO:0009214)2.81279348
48neuronal stem cell maintenance (GO:0097150)2.76073239
49limb bud formation (GO:0060174)2.75326359
50dendritic spine morphogenesis (GO:0060997)2.75026108
51reflex (GO:0060004)2.74257804
52positive regulation of synapse assembly (GO:0051965)2.74179609
53negative regulation of neurotransmitter transport (GO:0051589)2.72579396
54regulation of synapse structural plasticity (GO:0051823)2.72033285
55neuronal action potential propagation (GO:0019227)2.71789337
56calcium ion-dependent exocytosis (GO:0017156)2.70626291
57regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.69997314
58protein polyglutamylation (GO:0018095)2.67982305
59neural tube formation (GO:0001841)2.67584575
60cilium organization (GO:0044782)2.66436419
61intraciliary transport (GO:0042073)2.64713125
62protein localization to cilium (GO:0061512)2.63750570
63membrane depolarization during action potential (GO:0086010)2.62818908
64regulation of platelet aggregation (GO:0090330)2.60264635
65glutamate receptor signaling pathway (GO:0007215)2.58883621
66regulation of activation of Janus kinase activity (GO:0010533)2.58563740
67neuronal action potential (GO:0019228)2.57879754
68cilium assembly (GO:0042384)2.57571975
69tachykinin receptor signaling pathway (GO:0007217)2.57192525
70negative regulation of cytosolic calcium ion concentration (GO:0051481)2.56747762
71spinal cord development (GO:0021510)2.56199368
72cAMP catabolic process (GO:0006198)2.55706772
73mechanoreceptor differentiation (GO:0042490)2.55564803
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.54053114
75L-amino acid import (GO:0043092)2.53002166
76mesenchymal cell differentiation involved in kidney development (GO:0072161)2.52271580
77mesenchymal cell differentiation involved in renal system development (GO:2001012)2.52271580
78inner ear receptor stereocilium organization (GO:0060122)2.52190458
79piRNA metabolic process (GO:0034587)2.50064238
80G-protein coupled receptor internalization (GO:0002031)2.48625266
81negative regulation of neurotransmitter secretion (GO:0046929)2.47777803
82positive regulation of meiosis (GO:0045836)2.47472482
83positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.46856541
84negative regulation of homotypic cell-cell adhesion (GO:0034111)2.46821200
85microtubule bundle formation (GO:0001578)2.46026296
86response to epinephrine (GO:0071871)2.44895949
87transmission of nerve impulse (GO:0019226)2.44541188
88histone H3-K9 methylation (GO:0051567)2.43695386
89negative regulation of myoblast differentiation (GO:0045662)2.43686019
90establishment of mitochondrion localization (GO:0051654)2.43502288
91cerebellar Purkinje cell differentiation (GO:0021702)2.43183672
92positive regulation of CREB transcription factor activity (GO:0032793)2.42770748
93extracellular regulation of signal transduction (GO:1900115)2.42481015
94extracellular negative regulation of signal transduction (GO:1900116)2.42481015
95nonmotile primary cilium assembly (GO:0035058)2.42468897
96regulation of synapse assembly (GO:0051963)2.41644518
97histone H3-K9 modification (GO:0061647)2.41424797
98retinal cone cell development (GO:0046549)2.41242479
99cell differentiation involved in metanephros development (GO:0072202)2.40978756
100positive regulation of smooth muscle cell migration (GO:0014911)2.40165557
101photoreceptor cell maintenance (GO:0045494)2.39404465
102telencephalon development (GO:0021537)2.39335243
103positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.38588162
104centriole replication (GO:0007099)2.37639416
105daunorubicin metabolic process (GO:0044597)2.36661554
106polyketide metabolic process (GO:0030638)2.36661554
107doxorubicin metabolic process (GO:0044598)2.36661554
108ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.36637963
109retina layer formation (GO:0010842)2.36096933
110retinal ganglion cell axon guidance (GO:0031290)2.35396471
111otic vesicle formation (GO:0030916)2.34514346
112regulation of timing of cell differentiation (GO:0048505)2.34307646
113forebrain neuron differentiation (GO:0021879)2.33603302
114detection of other organism (GO:0098543)2.33373835
115import into cell (GO:0098657)2.32719157
116neuron remodeling (GO:0016322)2.32635428
117camera-type eye morphogenesis (GO:0048593)2.31945632
118synaptic transmission, glutamatergic (GO:0035249)2.31915417
119regulation of synaptic transmission, GABAergic (GO:0032228)2.31816238
120opioid receptor signaling pathway (GO:0038003)2.31796055
121serotonin metabolic process (GO:0042428)2.31787866
122auditory receptor cell stereocilium organization (GO:0060088)2.31657267
123androgen biosynthetic process (GO:0006702)2.31199071
124cellular response to epinephrine stimulus (GO:0071872)2.30824367
125negative regulation of translation, ncRNA-mediated (GO:0040033)2.30643329
126regulation of translation, ncRNA-mediated (GO:0045974)2.30643329
127negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.30643329
128positive regulation of uterine smooth muscle contraction (GO:0070474)2.30019640
129mitochondrion transport along microtubule (GO:0047497)2.29779383
130establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.29779383
131cell-cell junction maintenance (GO:0045217)2.29182145
132cilium morphogenesis (GO:0060271)2.28715422
133positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.28560092
134regulation of male gonad development (GO:2000018)2.28270891
135negative regulation of osteoblast proliferation (GO:0033689)2.28100029
136adult walking behavior (GO:0007628)2.28060017
137regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.27818034
138retinal rod cell development (GO:0046548)2.27751397
139positive regulation of cellular amide metabolic process (GO:0034250)2.27576739
140somite development (GO:0061053)2.27569827
141G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.26990648
142cranial nerve structural organization (GO:0021604)2.26967523
143GPI anchor metabolic process (GO:0006505)2.26691496
144developmental pigmentation (GO:0048066)2.26166772
145eye photoreceptor cell differentiation (GO:0001754)2.25813342
146photoreceptor cell differentiation (GO:0046530)2.25813342
147synapse assembly (GO:0007416)2.25394132
148negative regulation of stem cell proliferation (GO:2000647)2.25382675
149cell differentiation in hindbrain (GO:0021533)2.24905563
150mature B cell differentiation (GO:0002335)2.24312862
151positive regulation of meiotic cell cycle (GO:0051446)2.23366565
152establishment of protein localization to Golgi (GO:0072600)2.23012282
153GPI anchor biosynthetic process (GO:0006506)2.22909327
154cellular component assembly involved in morphogenesis (GO:0010927)2.22312634
155dendritic cell chemotaxis (GO:0002407)2.22178369
156neuron-neuron synaptic transmission (GO:0007270)2.22153164
157energy homeostasis (GO:0097009)2.21439380
158regulation of neurotransmitter uptake (GO:0051580)2.21098085
159detection of bacterium (GO:0016045)2.20567521
160regulation of inositol phosphate biosynthetic process (GO:0010919)2.20452939
161mannosylation (GO:0097502)2.19113568
162G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.18897134
163detection of mechanical stimulus involved in sensory perception (GO:0050974)2.17546390
164response to redox state (GO:0051775)2.17415658
165behavioral response to nicotine (GO:0035095)2.16085884
166regulation of non-canonical Wnt signaling pathway (GO:2000050)2.15829925
167cell differentiation involved in kidney development (GO:0061005)2.15222520
168cranial nerve morphogenesis (GO:0021602)2.15075568
169detection of light stimulus involved in sensory perception (GO:0050962)2.14980604
170detection of light stimulus involved in visual perception (GO:0050908)2.14980604
171protein localization to synapse (GO:0035418)2.14713069
172DNA integration (GO:0015074)2.13812774
173preassembly of GPI anchor in ER membrane (GO:0016254)2.13601474
174negative regulation of execution phase of apoptosis (GO:1900118)2.13023615
175glycerophospholipid catabolic process (GO:0046475)2.12950476
176serotonin receptor signaling pathway (GO:0007210)2.12926863
177regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.12728409
178neurotransmitter uptake (GO:0001504)2.12216291

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.15666632
2EZH2_22144423_ChIP-Seq_EOC_Human3.16239528
3ZFP57_27257070_Chip-Seq_ESCs_Mouse2.89800138
4ZNF274_21170338_ChIP-Seq_K562_Hela2.51226140
5TAF15_26573619_Chip-Seq_HEK293_Human2.47274178
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37691008
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.36544182
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29964699
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25304799
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.25289602
11IGF1R_20145208_ChIP-Seq_DFB_Human2.22251680
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15865427
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.13208130
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10028174
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.07564046
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05200249
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.03964007
18SUZ12_27294783_Chip-Seq_NPCs_Mouse1.98994042
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96698349
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.96375887
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95605638
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.91676467
23P300_19829295_ChIP-Seq_ESCs_Human1.90210126
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88950934
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.86792964
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81817831
27EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.80529165
28NANOG_18555785_Chip-Seq_ESCs_Mouse1.80124917
29EZH2_27294783_Chip-Seq_NPCs_Mouse1.78528366
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78238648
31TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77983980
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76918404
33P53_22387025_ChIP-Seq_ESCs_Mouse1.73708871
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.72939249
35SUZ12_18555785_Chip-Seq_ESCs_Mouse1.72850841
36RNF2_27304074_Chip-Seq_NSC_Mouse1.72419379
37E2F1_18555785_Chip-Seq_ESCs_Mouse1.71300769
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69862947
39FUS_26573619_Chip-Seq_HEK293_Human1.69778775
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.69335099
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68307457
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68261846
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68261846
44STAT3_18555785_Chip-Seq_ESCs_Mouse1.65836844
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62626979
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62430412
47EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.61079379
48CMYC_18555785_Chip-Seq_ESCs_Mouse1.60214671
49SMAD4_21799915_ChIP-Seq_A2780_Human1.59437318
50P300_18555785_Chip-Seq_ESCs_Mouse1.57638583
51NMYC_18555785_Chip-Seq_ESCs_Mouse1.57217845
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56484635
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56289074
54ER_23166858_ChIP-Seq_MCF-7_Human1.55190187
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53561253
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.52876284
57CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52511674
58VDR_22108803_ChIP-Seq_LS180_Human1.51895712
59RUNX1_27457419_Chip-Seq_LIVER_Mouse1.51735061
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.50674258
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.49739888
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49141525
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48614105
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46739250
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.45251974
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44975217
67SOX2_18555785_Chip-Seq_ESCs_Mouse1.44183955
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43560338
69OCT4_18555785_Chip-Seq_ESCs_Mouse1.43474658
70AR_21572438_ChIP-Seq_LNCaP_Human1.40658192
71MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40278916
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39611615
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38597084
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38011642
75PU1_27457419_Chip-Seq_LIVER_Mouse1.37930063
76TAL1_26923725_Chip-Seq_HPCs_Mouse1.37322257
77EWS_26573619_Chip-Seq_HEK293_Human1.36667746
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35214799
79KLF4_18555785_Chip-Seq_ESCs_Mouse1.34624691
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34619868
81ZFX_18555785_Chip-Seq_ESCs_Mouse1.34441476
82REST_18959480_ChIP-ChIP_MESCs_Mouse1.34319840
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32781656
84STAT3_23295773_ChIP-Seq_U87_Human1.32439157
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32166760
86SMAD1_18555785_Chip-Seq_ESCs_Mouse1.30793297
87BCAT_22108803_ChIP-Seq_LS180_Human1.30649597
88BP1_19119308_ChIP-ChIP_Hs578T_Human1.28545480
89CTCF_18555785_Chip-Seq_ESCs_Mouse1.28089766
90ESRRB_18555785_Chip-Seq_ESCs_Mouse1.27669748
91* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25934378
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25459056
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.24659086
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24210178
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24122907
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22033262
97REST_21632747_ChIP-Seq_MESCs_Mouse1.21727980
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21688742
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21688742
100OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20981472
101TCF4_23295773_ChIP-Seq_U87_Human1.20950941
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20715675
103CBP_20019798_ChIP-Seq_JUKART_Human1.20715675
104KDM2B_26808549_Chip-Seq_REH_Human1.18495352
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18169282
106AR_25329375_ChIP-Seq_VCAP_Human1.18000916
107RXR_22108803_ChIP-Seq_LS180_Human1.16701255
108P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15343397
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.15241812
110SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14745279
111WDR5_24793694_ChIP-Seq_LNCAP_Human1.14629453
112RUNX2_22187159_ChIP-Seq_PCA_Human1.13354057
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12975477
114POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12970884
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12859750
116DROSHA_22980978_ChIP-Seq_HELA_Human1.12830750
117SMAD3_21741376_ChIP-Seq_ESCs_Human1.12631612
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.12331635
119TCF4_22108803_ChIP-Seq_LS180_Human1.07216344
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06772297
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.05426089
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02792119
123ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02146238
124RING1B_27294783_Chip-Seq_ESCs_Mouse1.00739977
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99823810
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99449787
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.98759269
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96383662
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95117807
130TP53_16413492_ChIP-PET_HCT116_Human0.93637261
131AR_19668381_ChIP-Seq_PC3_Human0.93302378
132STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92278732

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.06514106
2MP0003880_abnormal_central_pattern3.28105372
3MP0004885_abnormal_endolymph3.03490222
4MP0006292_abnormal_olfactory_placode2.93840004
5MP0005645_abnormal_hypothalamus_physiol2.66283126
6MP0005409_darkened_coat_color2.59976684
7MP0003787_abnormal_imprinting2.59372523
8MP0003136_yellow_coat_color2.58538613
9MP0001486_abnormal_startle_reflex2.43679214
10MP0005171_absent_coat_pigmentation2.43537436
11MP0005646_abnormal_pituitary_gland2.43406426
12MP0002653_abnormal_ependyma_morphology2.31127022
13MP0002102_abnormal_ear_morphology2.20521477
14MP0002876_abnormal_thyroid_physiology2.10977958
15MP0001986_abnormal_taste_sensitivity2.08688576
16MP0009745_abnormal_behavioral_response2.02253072
17MP0004742_abnormal_vestibular_system2.01061650
18MP0000566_synostosis2.00714029
19MP0002736_abnormal_nociception_after1.96931085
20MP0005423_abnormal_somatic_nervous1.96560423
21MP0001968_abnormal_touch/_nociception1.95436764
22MP0002735_abnormal_chemical_nociception1.88757252
23MP0004133_heterotaxia1.86016204
24MP0006276_abnormal_autonomic_nervous1.82963910
25MP0000569_abnormal_digit_pigmentation1.81218131
26MP0009046_muscle_twitch1.80567650
27MP0001905_abnormal_dopamine_level1.78755270
28MP0004142_abnormal_muscle_tone1.76254773
29MP0002272_abnormal_nervous_system1.75064529
30MP0001529_abnormal_vocalization1.65515817
31MP0002572_abnormal_emotion/affect_behav1.64012850
32MP0002067_abnormal_sensory_capabilities1.63516629
33MP0005551_abnormal_eye_electrophysiolog1.63496576
34MP0002277_abnormal_respiratory_mucosa1.62284098
35MP0002064_seizures1.57533614
36MP0004043_abnormal_pH_regulation1.53538127
37MP0008260_abnormal_autophagy1.52394599
38MP0003635_abnormal_synaptic_transmissio1.50585599
39MP0000015_abnormal_ear_pigmentation1.50127948
40MP0001502_abnormal_circadian_rhythm1.47186404
41MP0001963_abnormal_hearing_physiology1.45015859
42MP0000026_abnormal_inner_ear1.44572257
43MP0004381_abnormal_hair_follicle1.44438154
44MP0004859_abnormal_synaptic_plasticity1.43374248
45MP0010386_abnormal_urinary_bladder1.41485747
46MP0002734_abnormal_mechanical_nocicepti1.41431321
47MP0001440_abnormal_grooming_behavior1.39047414
48MP0000372_irregular_coat_pigmentation1.37739259
49MP0003195_calcinosis1.35862032
50MP0005379_endocrine/exocrine_gland_phen1.35410947
51MP0001501_abnormal_sleep_pattern1.32780076
52MP0008789_abnormal_olfactory_epithelium1.32086971
53MP0002063_abnormal_learning/memory/cond1.30898128
54MP0000955_abnormal_spinal_cord1.30702619
55MP0003283_abnormal_digestive_organ1.30637782
56MP0009697_abnormal_copulation1.28332535
57MP0005394_taste/olfaction_phenotype1.28142098
58MP0005499_abnormal_olfactory_system1.28142098
59MP0002928_abnormal_bile_duct1.27907779
60MP0002557_abnormal_social/conspecific_i1.27726352
61MP0000920_abnormal_myelination1.23703019
62MP0000778_abnormal_nervous_system1.22391287
63MP0008877_abnormal_DNA_methylation1.22376244
64MP0005075_abnormal_melanosome_morpholog1.21419733
65MP0001346_abnormal_lacrimal_gland1.20574421
66MP0000631_abnormal_neuroendocrine_gland1.20533693
67MP0001984_abnormal_olfaction1.19777646
68MP0003122_maternal_imprinting1.15685931
69MP0003878_abnormal_ear_physiology1.15361883
70MP0005377_hearing/vestibular/ear_phenot1.15361883
71MP0004130_abnormal_muscle_cell1.11749992
72MP0008995_early_reproductive_senescence1.11442829
73MP0006072_abnormal_retinal_apoptosis1.08813327
74MP0002148_abnormal_hypersensitivity_rea1.08721723
75MP0002638_abnormal_pupillary_reflex1.07665564
76MP0002163_abnormal_gland_morphology1.07534343
77MP0008004_abnormal_stomach_pH1.06768458
78MP0004782_abnormal_surfactant_physiolog1.02003836
79MP0004924_abnormal_behavior1.00740716
80MP0005386_behavior/neurological_phenoty1.00740716
81MP0001970_abnormal_pain_threshold1.00724061
82MP0003724_increased_susceptibility_to1.00284586
83MP0001485_abnormal_pinna_reflex0.99984608
84MP0002938_white_spotting0.97583615
85MP0005195_abnormal_posterior_eye0.96241295
86MP0005253_abnormal_eye_physiology0.92958331
87MP0004270_analgesia0.92689851
88MP0003879_abnormal_hair_cell0.92376569
89MP0002249_abnormal_larynx_morphology0.91175302
90MP0002752_abnormal_somatic_nervous0.89784700
91MP0002751_abnormal_autonomic_nervous0.89634002
92MP0002152_abnormal_brain_morphology0.88797588
93MP0000681_abnormal_thyroid_gland0.88353236
94MP0009379_abnormal_foot_pigmentation0.87350656
95MP0002184_abnormal_innervation0.85738568
96MP0009785_altered_susceptibility_to0.84265182
97MP0001835_abnormal_antigen_presentation0.83830666
98MP0002837_dystrophic_cardiac_calcinosis0.83421334
99MP0005671_abnormal_response_to0.82279317
100MP0008872_abnormal_physiological_respon0.81882247
101MP0005174_abnormal_tail_pigmentation0.81320676
102MP0004484_altered_response_of0.80847550
103MP0005310_abnormal_salivary_gland0.80454255
104MP0002095_abnormal_skin_pigmentation0.77570359
105MP0002733_abnormal_thermal_nociception0.76770778
106MP0008961_abnormal_basal_metabolism0.76360183
107MP0003690_abnormal_glial_cell0.75857102
108MP0001664_abnormal_digestion0.75769163
109MP0008875_abnormal_xenobiotic_pharmacok0.75696276
110MP0003633_abnormal_nervous_system0.75468219
111MP0002882_abnormal_neuron_morphology0.74964295
112MP0003121_genomic_imprinting0.73404465
113MP0003950_abnormal_plasma_membrane0.73328332
114MP0002396_abnormal_hematopoietic_system0.72074646
115MP0001765_abnormal_ion_homeostasis0.70927664
116MP0008569_lethality_at_weaning0.70736932
117MP0002822_catalepsy0.70535411
118MP0001293_anophthalmia0.70524230
119MP0004811_abnormal_neuron_physiology0.69723894
120MP0000049_abnormal_middle_ear0.69354509
121MP0002229_neurodegeneration0.68544022
122MP0000427_abnormal_hair_cycle0.68513689
123MP0002066_abnormal_motor_capabilities/c0.67415438
124MP0001790_abnormal_immune_system0.66894237
125MP0005387_immune_system_phenotype0.66894237
126MP0003938_abnormal_ear_development0.66301086
127MP0002132_abnormal_respiratory_system0.65553951
128MP0009250_abnormal_appendicular_skeleto0.65255324
129MP0003137_abnormal_impulse_conducting0.64412927
130MP0005448_abnormal_energy_balance0.63502385
131MP0001177_atelectasis0.62246524
132MP0003698_abnormal_male_reproductive0.60476124

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)4.31803746
2Abnormality of midbrain morphology (HP:0002418)3.98416675
3Molar tooth sign on MRI (HP:0002419)3.98416675
4Pancreatic cysts (HP:0001737)3.69951097
5Papilledema (HP:0001085)3.63239849
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47040584
7Focal motor seizures (HP:0011153)3.39724260
8Septo-optic dysplasia (HP:0100842)3.19572192
9Hypothermia (HP:0002045)3.09826336
10Abnormal ciliary motility (HP:0012262)3.02571248
11Congenital sensorineural hearing impairment (HP:0008527)3.00091883
12Oligodactyly (hands) (HP:0001180)2.99315613
13Chromsome breakage (HP:0040012)2.96803702
14Progressive cerebellar ataxia (HP:0002073)2.95227841
15Abnormal hair whorl (HP:0010721)2.89878922
16Patchy hypopigmentation of hair (HP:0011365)2.87172513
17Dynein arm defect of respiratory motile cilia (HP:0012255)2.83200499
18Absent/shortened dynein arms (HP:0200106)2.83200499
19Volvulus (HP:0002580)2.81500038
20White forelock (HP:0002211)2.80819751
21Epileptic encephalopathy (HP:0200134)2.76401332
22Cystic liver disease (HP:0006706)2.75270203
23Duplicated collecting system (HP:0000081)2.70719323
24True hermaphroditism (HP:0010459)2.69641389
25Decreased central vision (HP:0007663)2.68932963
26Protruding tongue (HP:0010808)2.65804484
27Abnormality of the renal collecting system (HP:0004742)2.62362382
28Tubulointerstitial nephritis (HP:0001970)2.61109957
29Nephronophthisis (HP:0000090)2.59447052
30Optic nerve hypoplasia (HP:0000609)2.58872308
31Fair hair (HP:0002286)2.55185539
32Genetic anticipation (HP:0003743)2.55105316
33Decreased circulating renin level (HP:0003351)2.51346645
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.50454072
35Abnormality of the renal medulla (HP:0100957)2.48924634
36Medial flaring of the eyebrow (HP:0010747)2.48148532
37Anomalous pulmonary venous return (HP:0010772)2.47953688
38Abnormality of incisor morphology (HP:0011063)2.44391499
39Rhinitis (HP:0012384)2.40630087
40Truncal obesity (HP:0001956)2.37904838
41Congenital stationary night blindness (HP:0007642)2.36733923
42Chronic hepatic failure (HP:0100626)2.36195723
43Oligodactyly (HP:0012165)2.36047731
44Widely spaced teeth (HP:0000687)2.34927449
45Absent septum pellucidum (HP:0001331)2.34094538
46Abnormal respiratory epithelium morphology (HP:0012253)2.32993744
47Abnormal respiratory motile cilium morphology (HP:0005938)2.32993744
48Hemiparesis (HP:0001269)2.31394712
49Absent speech (HP:0001344)2.30843531
50Abnormal respiratory motile cilium physiology (HP:0012261)2.29926129
51Abnormality of the pubic bones (HP:0003172)2.29881973
52Abnormal drinking behavior (HP:0030082)2.28638522
53Polydipsia (HP:0001959)2.28638522
54Renal cortical cysts (HP:0000803)2.26841133
55Aplasia cutis congenita (HP:0001057)2.23335130
56Type II lissencephaly (HP:0007260)2.22843730
57Tented upper lip vermilion (HP:0010804)2.21711086
58Aplasia/Hypoplasia of the fovea (HP:0008060)2.19967213
59Hypoplasia of the fovea (HP:0007750)2.19967213
60Nephrogenic diabetes insipidus (HP:0009806)2.17997594
61Bronchiectasis (HP:0002110)2.17417760
62Keratoconus (HP:0000563)2.15389517
63Increased corneal curvature (HP:0100692)2.15389517
64Generalized hypopigmentation of hair (HP:0011358)2.14917632
65Gaze-evoked nystagmus (HP:0000640)2.14332253
66Abnormality of the pulmonary veins (HP:0011718)2.14118118
67Focal seizures (HP:0007359)2.13985269
68Aplasia/Hypoplasia of the spleen (HP:0010451)2.13227432
69Blue irides (HP:0000635)2.10927118
70Gait imbalance (HP:0002141)2.10770780
71Neuroendocrine neoplasm (HP:0100634)2.10453532
72Pancreatic fibrosis (HP:0100732)2.08298497
73Congenital primary aphakia (HP:0007707)2.07313154
74Abnormality of the septum pellucidum (HP:0007375)2.06967353
75Aplasia/Hypoplasia of the sternum (HP:0006714)2.06828109
76Male pseudohermaphroditism (HP:0000037)2.06540266
77Renal Fanconi syndrome (HP:0001994)2.05436051
78Postaxial foot polydactyly (HP:0001830)2.04870442
79Osteomalacia (HP:0002749)2.04126115
80Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.03884076
81Degeneration of the lateral corticospinal tracts (HP:0002314)2.03884076
82Abnormality of the aortic arch (HP:0012303)2.03076852
83Type I transferrin isoform profile (HP:0003642)2.02954881
84Hyperventilation (HP:0002883)2.01753877
85Abnormality of DNA repair (HP:0003254)2.01521555
86Prostate neoplasm (HP:0100787)2.01474087
87Reduced antithrombin III activity (HP:0001976)2.01126070
88Progressive inability to walk (HP:0002505)2.01081898
89Large for gestational age (HP:0001520)2.00534461
90Abnormality of macular pigmentation (HP:0008002)1.99439891
91Asplenia (HP:0001746)1.98138120
92Severe visual impairment (HP:0001141)1.96748844
93Retinitis pigmentosa (HP:0000510)1.95916931
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.95650482
95Abnormal eating behavior (HP:0100738)1.95633763
96Postaxial hand polydactyly (HP:0001162)1.95449524
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94443933
98Polyphagia (HP:0002591)1.93957724
99Hemiplegia (HP:0002301)1.93603068
100Parakeratosis (HP:0001036)1.93020885
101Urinary bladder sphincter dysfunction (HP:0002839)1.92119370
102Hypoplastic ischia (HP:0003175)1.91732988
103Abnormal rod and cone electroretinograms (HP:0008323)1.91515624
104Inability to walk (HP:0002540)1.91347483
105Sclerocornea (HP:0000647)1.89763766
106Tubular atrophy (HP:0000092)1.89663318
107Stomach cancer (HP:0012126)1.89209494
108Hypoplastic left heart (HP:0004383)1.88851400
109Nonprogressive disorder (HP:0003680)1.88427433
110Drooling (HP:0002307)1.87404723
111Retrobulbar optic neuritis (HP:0100654)1.86616685
112Optic neuritis (HP:0100653)1.86616685
113Abnormality of renal resorption (HP:0011038)1.86510160
114Intestinal atresia (HP:0011100)1.85996467
115Abnormality of the ischium (HP:0003174)1.85709002
116Fetal akinesia sequence (HP:0001989)1.85506932
117Abnormality of the fovea (HP:0000493)1.85152314
118Occipital encephalocele (HP:0002085)1.84564123
119Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84553142
120Alveolar cell carcinoma (HP:0006519)1.84126480
121Anophthalmia (HP:0000528)1.84061004
122Conical tooth (HP:0000698)1.83858653
123Hypoplastic heart (HP:0001961)1.83551965
124Thyroid-stimulating hormone excess (HP:0002925)1.83373229
125Agitation (HP:0000713)1.83200753
126Cerebellar dysplasia (HP:0007033)1.83045177
127Aplasia/Hypoplasia of the tibia (HP:0005772)1.81964638
128Narrow forehead (HP:0000341)1.81287515
129Bilateral microphthalmos (HP:0007633)1.81125141
130Broad-based gait (HP:0002136)1.79898208
131Congenital hepatic fibrosis (HP:0002612)1.79640914
132Excessive salivation (HP:0003781)1.79264284
133Upper limb muscle weakness (HP:0003484)1.78487993
134Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78110369
135Poor coordination (HP:0002370)1.77687252
136Pachygyria (HP:0001302)1.77460081
137Genital tract atresia (HP:0001827)1.77191197
138Myokymia (HP:0002411)1.76684751
139Attenuation of retinal blood vessels (HP:0007843)1.75932191
140Recurrent pneumonia (HP:0006532)1.75727970
141Abnormality of the nasal septum (HP:0000419)1.75227706
142Anencephaly (HP:0002323)1.74894315
143Aplasia/Hypoplasia of the lens (HP:0008063)1.74073704
1443-Methylglutaconic aciduria (HP:0003535)1.73751309
145Vaginal atresia (HP:0000148)1.73446481
146Duplication of thumb phalanx (HP:0009942)1.73303188
147Polyuria (HP:0000103)1.73083530
148Agammaglobulinemia (HP:0004432)1.73082705
149Chronic mucocutaneous candidiasis (HP:0002728)1.72569933
150Recurrent cutaneous fungal infections (HP:0011370)1.72569933
151Increased IgM level (HP:0003496)1.72346831
152Abnormality of the renal cortex (HP:0011035)1.71542342
153Hypoplastic iliac wings (HP:0002866)1.71015629
154Atonic seizures (HP:0010819)1.70933474
155Abolished electroretinogram (ERG) (HP:0000550)1.70757292
156Short tibia (HP:0005736)1.70685822
157Cutaneous finger syndactyly (HP:0010554)1.69959209
158Submucous cleft hard palate (HP:0000176)1.69513505
159Abnormal delayed hypersensitivity skin test (HP:0002963)1.67535568
160Median cleft lip (HP:0000161)1.67365400
161Prolonged bleeding time (HP:0003010)1.66880655

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.85888256
2TNIK3.62722814
3PRKD32.74169993
4STK162.72479461
5PRPF4B2.37631920
6MAP2K72.33070866
7PNCK2.20534827
8TXK2.12758952
9MAP4K22.08746606
10ZAK2.05755095
11NEK62.02813654
12SIK32.01635390
13MAP3K141.97867695
14ADRBK21.92052817
15NUAK11.85065763
16EIF2AK21.80020111
17GRK71.77847796
18IRAK31.73023434
19MUSK1.73007529
20IRAK41.72592302
21INSRR1.72374940
22YES11.71957709
23MAPK131.66995299
24NTRK31.65523887
25BMPR21.59489651
26OXSR11.59063989
27MKNK21.57479598
28DAPK21.57200451
29GRK11.53623316
30STK391.47923636
31NEK21.44433122
32MAP3K131.42101366
33WNK41.40625063
34PKN11.27685067
35BMPR1B1.26935170
36SGK21.20079005
37MKNK11.19688873
38BCR1.19639472
39TEC1.17278839
40AKT31.16071985
41CLK11.15827353
42TNK21.14153296
43CDK31.12740875
44MAP3K71.04786881
45SGK2231.04213617
46SGK4941.04213617
47MARK21.03373147
48VRK11.02748546
49PAK31.00289981
50PRKCE0.99167412
51PIK3CA0.98485202
52CAMKK10.98130398
53RIPK40.94334280
54IRAK10.94326229
55IRAK20.93144502
56SRPK10.91551125
57CAMKK20.90120022
58PIK3CG0.89040177
59STK110.88792481
60CDK80.86927395
61EPHA40.86874106
62TYRO30.86581245
63STK380.85041135
64EIF2AK30.83901090
65FES0.83569151
66PRKCH0.82989486
67PLK20.80930268
68PRKD20.80063339
69TIE10.78244760
70MAP3K120.77814120
71IKBKE0.76812487
72PBK0.75001095
73MAP4K10.73964455
74FGFR20.72885881
75MAP2K40.71183111
76ACVR1B0.71103516
77PINK10.70185889
78MAPKAPK50.69917420
79IKBKB0.68288744
80CAMK2B0.67807792
81MARK10.67328234
82PTK2B0.65669441
83STK38L0.65408649
84EPHA30.65364262
85TAOK30.64587733
86CAMK2A0.63843794
87NLK0.63038007
88PRKG10.60670722
89TLK10.58167878
90NTRK20.57660205
91MAPK150.55979522
92CAMK1G0.55935937
93BLK0.54908868
94MARK30.53441230
95ERBB30.53384580
96SIK20.52809841
97CDK50.52440478
98SGK10.51655885
99CAMK2D0.50644464
100BTK0.50535049
101LYN0.50099242
102FRK0.49805475
103PAK60.49615182
104DYRK1B0.48903136
105ERBB20.48483019
106PRKCQ0.48481163
107WNK30.48438102
108OBSCN0.48314557
109STK240.47290233
110PHKG20.47095061
111PHKG10.47095061
112ITK0.46354108
113NME10.45347082
114EPHB20.45071322
115HIPK20.45041847
116KIT0.44786300
117CDK190.44106491
118CAMK40.44057946
119MAPK70.43979026
120UHMK10.43648472
121FLT30.43561523
122CSNK1A1L0.43308033
123WNK10.41683788
124DMPK0.40730233
125TGFBR10.40453246
126TRPM70.39804030
127DYRK1A0.39677192
128CAMK10.38406107
129SYK0.37648037
130PRKACA0.37548646
131CSNK1G10.37481095
132ADRBK10.37436400
133SGK30.37169951
134CSNK1G30.37123443
135PRKCG0.36838954
136MST40.36515204
137DYRK20.36055598
138RPS6KA50.36037126
139PRKCZ0.35627793
140MAP3K40.35351708
141PRKAA20.32041283
142MAP2K20.31785616

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.41846157
2Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.45185383
3Dorso-ventral axis formation_Homo sapiens_hsa043202.28173999
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.26481058
5Morphine addiction_Homo sapiens_hsa050322.07710572
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06261625
7Phototransduction_Homo sapiens_hsa047441.98622555
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96997857
9Taste transduction_Homo sapiens_hsa047421.89789216
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.89578025
11Serotonergic synapse_Homo sapiens_hsa047261.84418780
12Autoimmune thyroid disease_Homo sapiens_hsa053201.82756836
13Sphingolipid metabolism_Homo sapiens_hsa006001.81841090
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.71413883
15Ether lipid metabolism_Homo sapiens_hsa005651.70285946
16Glutamatergic synapse_Homo sapiens_hsa047241.63442252
17Rheumatoid arthritis_Homo sapiens_hsa053231.59366947
18Allograft rejection_Homo sapiens_hsa053301.53453451
19Butanoate metabolism_Homo sapiens_hsa006501.52147711
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51993054
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.49596204
22Graft-versus-host disease_Homo sapiens_hsa053321.49350209
23Fatty acid elongation_Homo sapiens_hsa000621.48110695
24GABAergic synapse_Homo sapiens_hsa047271.47006918
25Protein export_Homo sapiens_hsa030601.43496239
26Arachidonic acid metabolism_Homo sapiens_hsa005901.41861492
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.41306401
28Fanconi anemia pathway_Homo sapiens_hsa034601.39392909
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.38856501
30Collecting duct acid secretion_Homo sapiens_hsa049661.32778587
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32001835
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30161217
33Olfactory transduction_Homo sapiens_hsa047401.27344351
34Circadian entrainment_Homo sapiens_hsa047131.24360319
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24101629
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.23692247
37Steroid biosynthesis_Homo sapiens_hsa001001.23088423
38Non-homologous end-joining_Homo sapiens_hsa034501.22896101
39Calcium signaling pathway_Homo sapiens_hsa040201.20843047
40Oxidative phosphorylation_Homo sapiens_hsa001901.20493530
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20096519
42Nitrogen metabolism_Homo sapiens_hsa009101.19151583
43Basal transcription factors_Homo sapiens_hsa030221.10291946
44Cocaine addiction_Homo sapiens_hsa050301.09341344
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07854611
46Hematopoietic cell lineage_Homo sapiens_hsa046401.07435320
47Asthma_Homo sapiens_hsa053101.07292027
48Salivary secretion_Homo sapiens_hsa049701.05076792
49Type I diabetes mellitus_Homo sapiens_hsa049401.03430966
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.03254411
51Ovarian steroidogenesis_Homo sapiens_hsa049131.01746687
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99183476
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98507119
54Axon guidance_Homo sapiens_hsa043600.97669370
55Primary immunodeficiency_Homo sapiens_hsa053400.97051299
56Synaptic vesicle cycle_Homo sapiens_hsa047210.95305304
57Amphetamine addiction_Homo sapiens_hsa050310.95134862
58Linoleic acid metabolism_Homo sapiens_hsa005910.92017467
59Cholinergic synapse_Homo sapiens_hsa047250.91420836
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.90163893
61Cardiac muscle contraction_Homo sapiens_hsa042600.89137343
62Insulin secretion_Homo sapiens_hsa049110.88771202
63African trypanosomiasis_Homo sapiens_hsa051430.88158709
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88089313
65MAPK signaling pathway_Homo sapiens_hsa040100.87520186
66Alzheimers disease_Homo sapiens_hsa050100.84523377
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83711793
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83684110
69Renin secretion_Homo sapiens_hsa049240.82369176
70Long-term depression_Homo sapiens_hsa047300.81382438
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81339674
72Inositol phosphate metabolism_Homo sapiens_hsa005620.81104330
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80238391
74Type II diabetes mellitus_Homo sapiens_hsa049300.80221862
75Tryptophan metabolism_Homo sapiens_hsa003800.78611322
76Phagosome_Homo sapiens_hsa041450.77711297
77Malaria_Homo sapiens_hsa051440.76329878
78Long-term potentiation_Homo sapiens_hsa047200.76289723
79beta-Alanine metabolism_Homo sapiens_hsa004100.75520734
80cAMP signaling pathway_Homo sapiens_hsa040240.75400158
81Caffeine metabolism_Homo sapiens_hsa002320.74367588
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72477908
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72290002
84Glycerolipid metabolism_Homo sapiens_hsa005610.70959229
85Chemical carcinogenesis_Homo sapiens_hsa052040.70951858
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70644307
87Homologous recombination_Homo sapiens_hsa034400.69993739
88Dopaminergic synapse_Homo sapiens_hsa047280.69022478
89Vitamin digestion and absorption_Homo sapiens_hsa049770.67245032
90Estrogen signaling pathway_Homo sapiens_hsa049150.65946485
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65541533
92Chemokine signaling pathway_Homo sapiens_hsa040620.64148589
93Measles_Homo sapiens_hsa051620.63826008
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63315140
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.63060376
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.62175351
97Parkinsons disease_Homo sapiens_hsa050120.62034650
98T cell receptor signaling pathway_Homo sapiens_hsa046600.60671192
99ABC transporters_Homo sapiens_hsa020100.60658570
100Ras signaling pathway_Homo sapiens_hsa040140.60285293
101Regulation of autophagy_Homo sapiens_hsa041400.59907556
102Notch signaling pathway_Homo sapiens_hsa043300.59774120
103Choline metabolism in cancer_Homo sapiens_hsa052310.59270671
104Peroxisome_Homo sapiens_hsa041460.58131282
105Other glycan degradation_Homo sapiens_hsa005110.57713566
106GnRH signaling pathway_Homo sapiens_hsa049120.57308479
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56867842
108Platelet activation_Homo sapiens_hsa046110.56677995
109Gap junction_Homo sapiens_hsa045400.55470719
110Huntingtons disease_Homo sapiens_hsa050160.55000325
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53688757
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52249950
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51719243
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51618527
115Retinol metabolism_Homo sapiens_hsa008300.51463160
116Hedgehog signaling pathway_Homo sapiens_hsa043400.51406513
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51162498
118Histidine metabolism_Homo sapiens_hsa003400.50324317
119Bile secretion_Homo sapiens_hsa049760.49781501
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48594084
121Thyroid hormone synthesis_Homo sapiens_hsa049180.48022252
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47773561
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.47245362
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47235050
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46876717
126Pancreatic secretion_Homo sapiens_hsa049720.46739129
127Basal cell carcinoma_Homo sapiens_hsa052170.46145168
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.45642825
129Fatty acid degradation_Homo sapiens_hsa000710.45107490
130Circadian rhythm_Homo sapiens_hsa047100.43081940
131Gastric acid secretion_Homo sapiens_hsa049710.43008581
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.43004211
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42200121
134Vibrio cholerae infection_Homo sapiens_hsa051100.40435622
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40417259
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40084258
137Herpes simplex infection_Homo sapiens_hsa051680.39611236
138Oxytocin signaling pathway_Homo sapiens_hsa049210.38527508
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.37894644
140cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37548458
141Purine metabolism_Homo sapiens_hsa002300.37545636

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