ZMAT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.44969839
2neuronal action potential propagation (GO:0019227)5.30250668
3neuron cell-cell adhesion (GO:0007158)5.19886713
4postsynaptic membrane organization (GO:0001941)4.95571143
5presynaptic membrane organization (GO:0097090)4.92036244
6viral life cycle (GO:0019058)4.91592011
7nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.89026202
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.83459834
9protein localization to synapse (GO:0035418)4.71007898
10translational elongation (GO:0006414)4.58814271
11histone H2B ubiquitination (GO:0033523)4.44266679
12positive regulation of dendritic spine morphogenesis (GO:0061003)4.40455232
13protein localization to endoplasmic reticulum (GO:0070972)4.36678046
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.28442357
15vocalization behavior (GO:0071625)4.27290089
16ribosomal small subunit assembly (GO:0000028)4.19505093
17short-term memory (GO:0007614)4.18931636
18negative regulation of synaptic transmission, GABAergic (GO:0032229)4.17535972
19positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling4.16811581
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.15129515
21ribosomal small subunit biogenesis (GO:0042274)4.10450063
22protein complex disassembly (GO:0043241)4.06442213
23positive regulation of dendritic spine development (GO:0060999)4.04374826
24glutamate receptor signaling pathway (GO:0007215)3.96782271
25translational initiation (GO:0006413)3.93611418
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.87780716
27ribosomal large subunit biogenesis (GO:0042273)3.85775403
28positive regulation of synapse assembly (GO:0051965)3.85227585
29macromolecular complex disassembly (GO:0032984)3.84000165
30maturation of SSU-rRNA (GO:0030490)3.83615950
31gamma-aminobutyric acid signaling pathway (GO:0007214)3.82434548
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.77776370
33regulation of early endosome to late endosome transport (GO:2000641)3.69044637
34synaptic vesicle exocytosis (GO:0016079)3.67965183
35positive regulation of membrane potential (GO:0045838)3.65602970
36regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3.65190330
37positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling3.65190330
38ATP synthesis coupled proton transport (GO:0015986)3.64638120
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.64638120
40protoporphyrinogen IX metabolic process (GO:0046501)3.62865101
41protein targeting to membrane (GO:0006612)3.61523254
423-UTR-mediated mRNA stabilization (GO:0070935)3.61161230
43neuron recognition (GO:0008038)3.60484057
44modulation by symbiont of host cellular process (GO:0044068)3.59881193
45positive regulation of cellular amide metabolic process (GO:0034250)3.56290887
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.51358301
47regulation of glutamate receptor signaling pathway (GO:1900449)3.48728792
48negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.45053381
49positive regulation of neurotransmitter secretion (GO:0001956)3.43585066
50neuron-neuron synaptic transmission (GO:0007270)3.42628519
51modulation by virus of host process (GO:0019054)3.42004762
52RNA stabilization (GO:0043489)3.40350950
53mRNA stabilization (GO:0048255)3.40350950
54formation of translation preinitiation complex (GO:0001731)3.39871468
55regulation of dendritic spine morphogenesis (GO:0061001)3.39106236
56regulation of dendritic spine development (GO:0060998)3.38803659
57viral transcription (GO:0019083)3.38572375
58modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.38206250
59positive regulation by organism of defense response of other organism involved in symbiotic interact3.38206250
60modulation by symbiont of host immune response (GO:0052553)3.38206250
61positive regulation by symbiont of host defense response (GO:0052509)3.38206250
62modulation by symbiont of host defense response (GO:0052031)3.38206250
63modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.38206250
64regulation of postsynaptic membrane potential (GO:0060078)3.34447773
65negative regulation of erythrocyte differentiation (GO:0045647)3.34022127
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.33715040
67synaptic transmission, glutamatergic (GO:0035249)3.31697919
68regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.28359165
69transmission of nerve impulse (GO:0019226)3.27261548
70regulation of chromatin binding (GO:0035561)3.25720048
71viral protein processing (GO:0019082)3.25294400
72axon ensheathment in central nervous system (GO:0032291)3.23613877
73central nervous system myelination (GO:0022010)3.23613877
74respiratory electron transport chain (GO:0022904)3.21136568
75translational termination (GO:0006415)3.20715414
76regulation of glutamate secretion (GO:0014048)3.18060365
77regulation of long-term neuronal synaptic plasticity (GO:0048169)3.17531644
78ribonucleoprotein complex biogenesis (GO:0022613)3.14586501
79electron transport chain (GO:0022900)3.14190860
80protein localization to endosome (GO:0036010)3.11167023
81regulation of short-term neuronal synaptic plasticity (GO:0048172)3.09516221
82cellular response to nerve growth factor stimulus (GO:1990090)3.07729811
83response to nerve growth factor (GO:1990089)3.07729811
84dendritic spine morphogenesis (GO:0060997)3.06101479
85positive regulation of neurotransmitter transport (GO:0051590)3.05257849
86mating behavior (GO:0007617)3.03250076
87positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.02853766
88regulation of protein kinase A signaling (GO:0010738)3.02738806
89negative regulation of microtubule polymerization (GO:0031115)3.02632320
90regulation of respiratory system process (GO:0044065)3.02625094
91regulation of pigment cell differentiation (GO:0050932)3.00277962
92regulation of synapse assembly (GO:0051963)3.00196977
93regulation of synaptic vesicle exocytosis (GO:2000300)2.99413757
94regulation of vesicle fusion (GO:0031338)2.99097131
95negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.98470540
96regulation of dopamine metabolic process (GO:0042053)2.96455612
97regulation of catecholamine metabolic process (GO:0042069)2.96455612
98positive regulation of DNA-templated transcription, elongation (GO:0032786)2.95914096
99regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.95609887
100G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.93388431
101nucleobase-containing small molecule interconversion (GO:0015949)2.93078383
102neurotransmitter-gated ion channel clustering (GO:0072578)2.93056485
103positive regulation of Cdc42 GTPase activity (GO:0043089)2.89019026
104long-term memory (GO:0007616)2.88966066
105erythrocyte development (GO:0048821)2.88282614
106righting reflex (GO:0060013)2.88137578
107startle response (GO:0001964)2.87482869
108GTP biosynthetic process (GO:0006183)2.85792174
109glutamate secretion (GO:0014047)2.85412976
110synaptic transmission, dopaminergic (GO:0001963)2.84738298
111exploration behavior (GO:0035640)2.84721541
112virion assembly (GO:0019068)2.84543502
113regulation of nucleobase-containing compound transport (GO:0032239)2.83879441
114axonal fasciculation (GO:0007413)2.83712692
115positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.83364044
116positive regulation of response to oxidative stress (GO:1902884)2.82138246
117positive regulation of cellular response to oxidative stress (GO:1900409)2.82138246
118chaperone-mediated protein transport (GO:0072321)2.81574344
119establishment of integrated proviral latency (GO:0075713)2.81301575
120regulation of respiratory gaseous exchange (GO:0043576)2.80558343
121establishment of protein localization to membrane (GO:0090150)2.79719184
122regulation of neuronal synaptic plasticity (GO:0048168)2.79443612
123response to histamine (GO:0034776)2.78752703
124cellular response to virus (GO:0098586)2.78739643
125spliceosomal tri-snRNP complex assembly (GO:0000244)2.78445949
126positive regulation of synaptic transmission, GABAergic (GO:0032230)2.77249235
127nuclear-transcribed mRNA catabolic process (GO:0000956)2.76696345
128regulation of RNA export from nucleus (GO:0046831)2.75678363
129protein localization to cilium (GO:0061512)2.75496809
130pentose-phosphate shunt (GO:0006098)2.75363662
131cotranslational protein targeting to membrane (GO:0006613)2.73848550
132protoporphyrinogen IX biosynthetic process (GO:0006782)2.73528161
133behavioral fear response (GO:0001662)2.71438029
134behavioral defense response (GO:0002209)2.71438029
135fear response (GO:0042596)2.71268169
136negative regulation of neurotransmitter transport (GO:0051589)2.71077607
137regulation of axon regeneration (GO:0048679)2.70537817
138regulation of neuron projection regeneration (GO:0070570)2.70537817
139synaptic vesicle maturation (GO:0016188)2.69320399
140mRNA catabolic process (GO:0006402)2.68381130
141membrane depolarization (GO:0051899)2.67886508
142positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.67629502
143protein targeting to ER (GO:0045047)2.67455804
144phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.66967642
145negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.66630537
146calcium-mediated signaling using intracellular calcium source (GO:0035584)2.64892257
147regulation of synaptic vesicle transport (GO:1902803)2.64759702
148SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.64421563
149localization within membrane (GO:0051668)2.63258443
150response to parathyroid hormone (GO:0071107)2.63080364
151regulation of synaptic transmission, GABAergic (GO:0032228)2.62954914
152mitotic chromosome condensation (GO:0007076)2.62602606
153regulation of cellular amide metabolic process (GO:0034248)2.62557274
154protein neddylation (GO:0045116)2.62508066
155mitochondrial fusion (GO:0008053)2.61950425
156positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.61498570
157regulation of protein dephosphorylation (GO:0035304)2.61262426
158neuron remodeling (GO:0016322)2.61200249
159cellular protein complex disassembly (GO:0043624)2.60879546
160learning (GO:0007612)2.59735031
161regulation of oxidative phosphorylation (GO:0002082)2.59284654
162protein localization to microtubule (GO:0035372)2.58697299
163cerebral cortex radially oriented cell migration (GO:0021799)2.58466541
164establishment of protein localization to endoplasmic reticulum (GO:0072599)2.58431612
165long-term synaptic potentiation (GO:0060291)2.58141649
166synapse assembly (GO:0007416)2.56832019
167regulation of amyloid precursor protein catabolic process (GO:1902991)2.55446761
168regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.55348115
169regulation of defense response to virus by virus (GO:0050690)2.53051010
170RNA catabolic process (GO:0006401)2.51421529
171positive regulation of mitochondrion organization (GO:0010822)2.48549072
172cellular copper ion homeostasis (GO:0006878)2.47761476
173response to peptidoglycan (GO:0032494)2.46137075
174clathrin coat assembly (GO:0048268)2.44277349
175myeloid cell homeostasis (GO:0002262)2.44025347
176positive regulation of protein dephosphorylation (GO:0035307)2.43744809
177positive regulation of protein export from nucleus (GO:0046827)2.43516089
178establishment of viral latency (GO:0019043)2.41095934
179peptidyl-proline hydroxylation (GO:0019511)2.40068915
180protein maturation by protein folding (GO:0022417)2.37899189
181protein hydroxylation (GO:0018126)2.37610243
182cortical actin cytoskeleton organization (GO:0030866)2.36807286
183regulation of beta-amyloid formation (GO:1902003)2.34744498
184negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.31758900
185translation (GO:0006412)2.29634929
186protein localization to membrane (GO:0072657)2.28205090
187regulation of DNA-templated transcription, elongation (GO:0032784)2.27268576
188protein targeting (GO:0006605)2.24627304
189nerve growth factor signaling pathway (GO:0038180)2.24115871
190regulation of superoxide anion generation (GO:0032928)2.22792607
191response to host immune response (GO:0052572)2.21561262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.57029782
2GBX2_23144817_ChIP-Seq_PC3_Human3.88294710
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.59608194
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.52265410
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49395055
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01596853
7TAF15_26573619_Chip-Seq_HEK293_Human3.00932068
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.82811225
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81879640
10VDR_21846776_ChIP-Seq_THP-1_Human2.68517375
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64065940
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.63646170
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62352525
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59438178
15MYC_22102868_ChIP-Seq_BL_Human2.57475185
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56748909
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56748909
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45540109
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.44795706
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43209092
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.41463037
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.38888459
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34469048
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.29144964
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.23407507
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23332719
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17372538
28TP63_17297297_ChIP-ChIP_HaCaT_Human2.13495532
29IGF1R_20145208_ChIP-Seq_DFB_Human2.08405138
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06304199
31MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05673218
32SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05355292
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.03810413
34REST_21632747_ChIP-Seq_MESCs_Mouse2.03704013
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.99708128
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99404891
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98441266
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95007344
39LXR_22292898_ChIP-Seq_THP-1_Human1.93459863
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.93399152
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.91954241
42VDR_22108803_ChIP-Seq_LS180_Human1.90621685
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.86967361
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85930401
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85578408
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85226396
47FUS_26573619_Chip-Seq_HEK293_Human1.85084330
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84845701
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82403321
50* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80903302
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79741466
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.79354948
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.77427877
54P300_19829295_ChIP-Seq_ESCs_Human1.76220190
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.75758873
56XRN2_22483619_ChIP-Seq_HELA_Human1.72195927
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69905623
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69282815
59KDM2B_26808549_Chip-Seq_DND41_Human1.68153031
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68132606
61KDM2B_26808549_Chip-Seq_K562_Human1.66964903
62RNF2_27304074_Chip-Seq_NSC_Mouse1.66363308
63TCF7_22412390_ChIP-Seq_EML_Mouse1.65995276
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.64590880
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64538269
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.59986431
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59031438
68AR_21572438_ChIP-Seq_LNCaP_Human1.58553281
69* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.57677782
70CLOCK_20551151_ChIP-Seq_293T_Human1.56260505
71RACK7_27058665_Chip-Seq_MCF-7_Human1.54708403
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53231539
73ZNF274_21170338_ChIP-Seq_K562_Hela1.51334781
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50230239
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.50102362
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.50043846
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.49021186
78VDR_24763502_ChIP-Seq_THP-1_Human1.48315278
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47153295
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46720669
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43605717
82TFEB_21752829_ChIP-Seq_HELA_Human1.43011432
83RARB_27405468_Chip-Seq_BRAIN_Mouse1.42959439
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42506573
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41392317
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41336561
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39938647
88MAF_26560356_Chip-Seq_TH1_Human1.39869769
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.37738856
90SMAD4_21799915_ChIP-Seq_A2780_Human1.35852176
91MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35442063
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35408325
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35087323
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32556376
95GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.32248270
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32109880
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31829784
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31350220
99BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30964672
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30937556
101KDM2B_26808549_Chip-Seq_JURKAT_Human1.30798591
102MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30402811
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30373823
104* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30080044
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29307640
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.27103123
107EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26614494
108RUNX1_22412390_ChIP-Seq_EML_Mouse1.26193856
109EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26120476
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25268699
111FOXM1_23109430_ChIP-Seq_U2OS_Human1.24527843
112* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23668374
113SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23072071
114TET1_21451524_ChIP-Seq_MESCs_Mouse1.23018020
115IRF1_19129219_ChIP-ChIP_H3396_Human1.22856570
116SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22763159
117NCOR1_26117541_ChIP-Seq_K562_Human1.22705632
118POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21931955
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21815400
120EWS_26573619_Chip-Seq_HEK293_Human1.21803823
121MAF_26560356_Chip-Seq_TH2_Human1.21194004
122ER_23166858_ChIP-Seq_MCF-7_Human1.20128161
123TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19805807
124MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18974039
125POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18907869
126* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18161355
127ATF3_27146783_Chip-Seq_COLON_Human1.17431085
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16530898
129UTX_26944678_Chip-Seq_JUKART_Human1.16358672
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16194218
131ZNF263_19887448_ChIP-Seq_K562_Human1.15345627
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14573291
133HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14523852
134WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13443539
135P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13400342
136E2F1_18555785_Chip-Seq_ESCs_Mouse1.13063031
137P53_22387025_ChIP-Seq_ESCs_Mouse1.12721614
138TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12465310
139PRDM14_20953172_ChIP-Seq_ESCs_Human1.12093719
140SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11724027
141PIAS1_25552417_ChIP-Seq_VCAP_Human1.10278865
142CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10030284
143MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09929200
144ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09631096
145MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09521900
146PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08849014
147EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08832081
148NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08687391
149CREB1_26743006_Chip-Seq_LNCaP_Human1.08473724
150KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07945007
151GATA1_19941827_ChIP-Seq_MEL_Mouse1.07384290
152P300_18555785_Chip-Seq_ESCs_Mouse1.06650382
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06041624
154SPI1_23547873_ChIP-Seq_NB4_Human1.05813803
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05501190
156CMYC_18555785_Chip-Seq_ESCs_Mouse1.05290130
157* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04855939
158AR_25329375_ChIP-Seq_VCAP_Human1.04693851
159SA1_27219007_Chip-Seq_ERYTHROID_Human1.04591257
160TTF2_22483619_ChIP-Seq_HELA_Human1.04556374
161CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04517066
162JUN_21703547_ChIP-Seq_K562_Human1.04109756
163RING1B_27294783_Chip-Seq_ESCs_Mouse1.03894174
164CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02855060
165UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02753640
166SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02101834
167CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01729097
168CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01611539
169ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01468917
170STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01278790
171SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01263418
172FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01153873
173SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01057956
174SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00924755
175FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00639421
176DROSHA_22980978_ChIP-Seq_HELA_Human1.00500667
177HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00495873
178RUNX2_22187159_ChIP-Seq_PCA_Human1.00153270
179SOX2_18555785_Chip-Seq_ESCs_Mouse0.99818150
180* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99563617
181NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99475195
182RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98368233
183MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96702945
184CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96687628
185* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96627705
186TP53_18474530_ChIP-ChIP_U2OS_Human0.96590049
187RING1B_27294783_Chip-Seq_NPCs_Mouse0.96284011
188NFE2_27457419_Chip-Seq_LIVER_Mouse0.94085567
189STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93292062
190KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92433411
191TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91869887
192GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91767961
193NMYC_18555785_Chip-Seq_ESCs_Mouse0.91233772
194ERG_21242973_ChIP-ChIP_JURKAT_Human0.90893610
195STAT3_18555785_Chip-Seq_ESCs_Mouse0.90359317
196MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87074885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.56908099
2MP0003123_paternal_imprinting4.40755008
3MP0009379_abnormal_foot_pigmentation4.28529478
4MP0004859_abnormal_synaptic_plasticity4.04489945
5MP0002877_abnormal_melanocyte_morpholog3.75930912
6MP0001188_hyperpigmentation3.36933615
7MP0003136_yellow_coat_color3.34565943
8MP0003303_peritoneal_inflammation3.19398875
9MP0003635_abnormal_synaptic_transmissio3.18042759
10MP0005451_abnormal_body_composition3.14345350
11MP0005058_abnormal_lysosome_morphology3.11030230
12MP0001968_abnormal_touch/_nociception3.05434507
13MP0004270_analgesia3.03195240
14MP0005409_darkened_coat_color3.01090689
15MP0008260_abnormal_autophagy2.97673498
16MP0009745_abnormal_behavioral_response2.89533469
17MP0003656_abnormal_erythrocyte_physiolo2.84215962
18MP0004185_abnormal_adipocyte_glucose2.67459307
19MP0002064_seizures2.61487927
20MP0006292_abnormal_olfactory_placode2.54656511
21MP0002736_abnormal_nociception_after2.47033480
22MP0002272_abnormal_nervous_system2.42456941
23MP0002063_abnormal_learning/memory/cond2.36333407
24MP0003705_abnormal_hypodermis_morpholog2.35436065
25MP0006276_abnormal_autonomic_nervous2.30227845
26MP0005083_abnormal_biliary_tract2.28389600
27MP0002572_abnormal_emotion/affect_behav2.28038730
28MP0009046_muscle_twitch2.25871949
29MP0001486_abnormal_startle_reflex2.22288338
30MP0003191_abnormal_cellular_cholesterol2.16130592
31MP0005423_abnormal_somatic_nervous2.12130008
32MP0002734_abnormal_mechanical_nocicepti2.10720924
33MP0001440_abnormal_grooming_behavior2.10031791
34MP0000604_amyloidosis1.96106959
35MP0002735_abnormal_chemical_nociception1.94155848
36MP0001905_abnormal_dopamine_level1.92851690
37MP0001348_abnormal_lacrimal_gland1.89817862
38MP0004233_abnormal_muscle_weight1.89551024
39MP0001970_abnormal_pain_threshold1.84049330
40MP0000778_abnormal_nervous_system1.82182201
41MP0001501_abnormal_sleep_pattern1.81766512
42MP0001529_abnormal_vocalization1.81689345
43MP0002067_abnormal_sensory_capabilities1.79046445
44MP0010234_abnormal_vibrissa_follicle1.74952186
45MP0004142_abnormal_muscle_tone1.71133308
46MP0003938_abnormal_ear_development1.69033815
47MP0009840_abnormal_foam_cell1.67227241
48MP0005464_abnormal_platelet_physiology1.66963985
49MP0002733_abnormal_thermal_nociception1.66578708
50MP0004381_abnormal_hair_follicle1.62744859
51MP0003300_gastrointestinal_ulcer1.62204625
52MP0002184_abnormal_innervation1.60915352
53MP0003436_decreased_susceptibility_to1.60532531
54MP0000858_altered_metastatic_potential1.57618291
55MP0005076_abnormal_cell_differentiation1.57349506
56MP0002557_abnormal_social/conspecific_i1.50731642
57MP0003121_genomic_imprinting1.46529776
58MP0004947_skin_inflammation1.43062639
59MP0004957_abnormal_blastocyst_morpholog1.41813526
60MP0008569_lethality_at_weaning1.39214022
61MP0009333_abnormal_splenocyte_physiolog1.38504240
62MP0003453_abnormal_keratinocyte_physiol1.37748715
63MP0003221_abnormal_cardiomyocyte_apopto1.37592694
64MP0002102_abnormal_ear_morphology1.36122168
65MP0003879_abnormal_hair_cell1.33444052
66MP0002132_abnormal_respiratory_system1.32406985
67MP0002909_abnormal_adrenal_gland1.31885075
68MP0000343_altered_response_to1.30625383
69MP0004145_abnormal_muscle_electrophysio1.29547860
70MP0002822_catalepsy1.29468034
71MP0003075_altered_response_to1.28701147
72MP0004742_abnormal_vestibular_system1.27587180
73MP0005666_abnormal_adipose_tissue1.26802050
74MP0005501_abnormal_skin_physiology1.23161202
75MP0001730_embryonic_growth_arrest1.21664132
76MP0001849_ear_inflammation1.21439264
77MP0002882_abnormal_neuron_morphology1.20413394
78MP0002796_impaired_skin_barrier1.20368674
79MP0000490_abnormal_crypts_of1.20301570
80MP0000631_abnormal_neuroendocrine_gland1.19562227
81MP0001986_abnormal_taste_sensitivity1.16822346
82MP0005174_abnormal_tail_pigmentation1.16568031
83MP0005551_abnormal_eye_electrophysiolog1.16072299
84MP0003806_abnormal_nucleotide_metabolis1.15990046
85MP0000685_abnormal_immune_system1.14732928
86MP0000955_abnormal_spinal_cord1.13912313
87MP0005171_absent_coat_pigmentation1.13191564
88MP0000678_abnormal_parathyroid_gland1.12026841
89MP0003172_abnormal_lysosome_physiology1.11536124
90MP0001984_abnormal_olfaction1.11259674
91MP0002066_abnormal_motor_capabilities/c1.11180326
92MP0003690_abnormal_glial_cell1.11092418
93MP0002419_abnormal_innate_immunity1.09996904
94MP0001963_abnormal_hearing_physiology1.09776449
95MP0005386_behavior/neurological_phenoty1.08707354
96MP0004924_abnormal_behavior1.08707354
97MP0000015_abnormal_ear_pigmentation1.07698652
98MP0002638_abnormal_pupillary_reflex1.07061977
99MP0001853_heart_inflammation1.06431124
100MP0004130_abnormal_muscle_cell1.06370332
101MP0002653_abnormal_ependyma_morphology1.04993892
102MP0005025_abnormal_response_to1.03470591
103MP0001485_abnormal_pinna_reflex1.02914576
104MP0000026_abnormal_inner_ear1.02150730
105MP0000920_abnormal_myelination1.02078242
106MP0000747_muscle_weakness0.99757666
107MP0002752_abnormal_somatic_nervous0.99400540
108MP0004811_abnormal_neuron_physiology0.97054866
109MP0003186_abnormal_redox_activity0.95589880
110MP0006072_abnormal_retinal_apoptosis0.94912920
111MP0002751_abnormal_autonomic_nervous0.93614907
112MP0005000_abnormal_immune_tolerance0.93261523
113MP0000350_abnormal_cell_proliferation0.92890464
114MP0005384_cellular_phenotype0.92244345
115MP0003091_abnormal_cell_migration0.91332637
116MP0002152_abnormal_brain_morphology0.90891371
117MP0002163_abnormal_gland_morphology0.90842809
118MP0000049_abnormal_middle_ear0.90646485
119MP0009278_abnormal_bone_marrow0.90494177
120MP0006036_abnormal_mitochondrial_physio0.89845524
121MP0005394_taste/olfaction_phenotype0.88894660
122MP0005499_abnormal_olfactory_system0.88894660
123MP0002876_abnormal_thyroid_physiology0.87440549
124MP0002229_neurodegeneration0.86706443
125MP0003329_amyloid_beta_deposits0.86622591
126MP0005379_endocrine/exocrine_gland_phen0.86572852
127MP0003632_abnormal_nervous_system0.86030553
128MP0005621_abnormal_cell_physiology0.85043651
129MP0003787_abnormal_imprinting0.84826887
130MP0003693_abnormal_embryo_hatching0.84718190
131MP0000358_abnormal_cell_content/0.84444999
132MP0003566_abnormal_cell_adhesion0.84417731
133MP0001727_abnormal_embryo_implantation0.83643815
134MP0002420_abnormal_adaptive_immunity0.83113487
135MP0001819_abnormal_immune_cell0.81559372
136MP0005310_abnormal_salivary_gland0.81420837
137MP0002398_abnormal_bone_marrow0.80187860
138MP0003111_abnormal_nucleus_morphology0.79001255
139MP0000681_abnormal_thyroid_gland0.78670827
140MP0001664_abnormal_digestion0.78638950
141MP0004885_abnormal_endolymph0.77931284
142MP0002080_prenatal_lethality0.77830012
143MP0001835_abnormal_antigen_presentation0.76973742
144MP0002148_abnormal_hypersensitivity_rea0.74797608
145MP0002723_abnormal_immune_serum0.74555347
146MP0003077_abnormal_cell_cycle0.73514067
147MP0002009_preneoplasia0.72640689
148MP0001502_abnormal_circadian_rhythm0.72449600
149MP0002452_abnormal_antigen_presenting0.72246391
150MP0004484_altered_response_of0.72076498
151MP0001790_abnormal_immune_system0.71485383
152MP0005387_immune_system_phenotype0.71485383
153MP0003828_pulmonary_edema0.70627748
154MP0005645_abnormal_hypothalamus_physiol0.70468378
155MP0000313_abnormal_cell_death0.69511361
156MP0008789_abnormal_olfactory_epithelium0.68950640
157MP0001851_eye_inflammation0.68831016
158MP0005623_abnormal_meninges_morphology0.68156091
159MP0005375_adipose_tissue_phenotype0.67501438
160MP0001915_intracranial_hemorrhage0.67357123
161MP0005646_abnormal_pituitary_gland0.67050587
162MP0003866_abnormal_defecation0.66848733
163MP0002429_abnormal_blood_cell0.65554104
164MP0008872_abnormal_physiological_respon0.65210231
165MP0002177_abnormal_outer_ear0.65188262
166MP0003633_abnormal_nervous_system0.65153212
167MP0000372_irregular_coat_pigmentation0.63942151
168MP0005253_abnormal_eye_physiology0.63274248
169MP0003122_maternal_imprinting0.62616744
170MP0008874_decreased_physiological_sensi0.62426481
171MP0003315_abnormal_perineum_morphology0.61757120
172MP0002249_abnormal_larynx_morphology0.61389998
173MP0005595_abnormal_vascular_smooth0.59367563
174MP0003861_abnormal_nervous_system0.58540913
175MP0003631_nervous_system_phenotype0.57677442
176MP0001346_abnormal_lacrimal_gland0.56759419
177MP0003634_abnormal_glial_cell0.55488841
178MP0002069_abnormal_eating/drinking_beha0.55030455
179MP0010386_abnormal_urinary_bladder0.53837248
180MP0005084_abnormal_gallbladder_morpholo0.53515791
181MP0004147_increased_porphyrin_level0.51701790
182MP0002277_abnormal_respiratory_mucosa0.48364202

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.50691445
2Myokymia (HP:0002411)4.08987903
3Focal seizures (HP:0007359)3.91456572
4Atonic seizures (HP:0010819)3.74525424
5Acute necrotizing encephalopathy (HP:0006965)3.72280867
6Increased hepatocellular lipid droplets (HP:0006565)3.51950865
7Epileptic encephalopathy (HP:0200134)3.47116767
8Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.43930661
9Mitochondrial inheritance (HP:0001427)3.39890625
10Hyperventilation (HP:0002883)3.27954108
11Progressive macrocephaly (HP:0004481)3.20131859
12Abnormal mitochondria in muscle tissue (HP:0008316)3.17746419
13Optic disc pallor (HP:0000543)3.16971794
14Broad-based gait (HP:0002136)3.13239344
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.11631365
16Renal Fanconi syndrome (HP:0001994)3.10769187
17Termporal pattern (HP:0011008)3.06310791
18Insidious onset (HP:0003587)3.06310791
19Febrile seizures (HP:0002373)3.04520322
20Visual hallucinations (HP:0002367)2.98805799
21Dialeptic seizures (HP:0011146)2.97161370
22Absence seizures (HP:0002121)2.95796371
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.94872700
24Absent/shortened dynein arms (HP:0200106)2.94872700
25Progressive cerebellar ataxia (HP:0002073)2.90619019
26Abnormal ciliary motility (HP:0012262)2.90500179
27Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.88094316
28Eczematoid dermatitis (HP:0000976)2.80584135
29Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.80083200
30Resting tremor (HP:0002322)2.79468887
31Diminished motivation (HP:0000745)2.79180299
32Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.76849625
33Insomnia (HP:0100785)2.75201916
34Supranuclear gaze palsy (HP:0000605)2.74951689
35Hyperparathyroidism (HP:0000843)2.73629347
36Papilledema (HP:0001085)2.72756828
37Hypothermia (HP:0002045)2.69355261
38Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.68967611
39Lipid accumulation in hepatocytes (HP:0006561)2.67307589
40Multiple enchondromatosis (HP:0005701)2.67272484
41Increased CSF lactate (HP:0002490)2.66065867
42Abnormality of cells of the erythroid lineage (HP:0012130)2.65272749
43Apathy (HP:0000741)2.63675032
44Hepatocellular necrosis (HP:0001404)2.61044919
45Acute encephalopathy (HP:0006846)2.59199130
46Abnormality of secondary sexual hair (HP:0009888)2.59164295
47Abnormality of the axillary hair (HP:0100134)2.59164295
48Recurrent bacterial skin infections (HP:0005406)2.57645627
49Abnormality of macrophages (HP:0004311)2.55335486
50Parakeratosis (HP:0001036)2.54290207
51Deep palmar crease (HP:0006191)2.54066065
52Gaze-evoked nystagmus (HP:0000640)2.51302231
53Abnormal respiratory epithelium morphology (HP:0012253)2.45329486
54Abnormal respiratory motile cilium morphology (HP:0005938)2.45329486
55Peripheral hypomyelination (HP:0007182)2.43870478
56Cholecystitis (HP:0001082)2.42374911
57Abnormal gallbladder physiology (HP:0012438)2.42374911
58Amblyopia (HP:0000646)2.40129445
59Macrocytic anemia (HP:0001972)2.38345641
60Progressive inability to walk (HP:0002505)2.36936690
61Thyroid-stimulating hormone excess (HP:0002925)2.36917761
62Achilles tendon contracture (HP:0001771)2.36683788
63Centrally nucleated skeletal muscle fibers (HP:0003687)2.35347939
64Recurrent abscess formation (HP:0002722)2.35167221
65Abnormal respiratory motile cilium physiology (HP:0012261)2.34967043
66Abnormal number of erythroid precursors (HP:0012131)2.33707258
67Absent speech (HP:0001344)2.31315704
68Pseudobulbar signs (HP:0002200)2.30555958
69Sensory axonal neuropathy (HP:0003390)2.30278816
70Delusions (HP:0000746)2.30231781
71Hypercortisolism (HP:0001578)2.29657946
72Flat occiput (HP:0005469)2.27241859
73Polycythemia (HP:0001901)2.27012230
74Recurrent gram-negative bacterial infections (HP:0005420)2.26869002
75Retinal dysplasia (HP:0007973)2.25744459
76Neuronal loss in central nervous system (HP:0002529)2.25364689
77Disinhibition (HP:0000734)2.23656088
78Generalized tonic-clonic seizures (HP:0002069)2.21552763
79Diplopia (HP:0000651)2.21310961
80Abnormality of binocular vision (HP:0011514)2.21310961
81Progressive muscle weakness (HP:0003323)2.21218542
82Abnormality of the Achilles tendon (HP:0005109)2.20600625
83Foot dorsiflexor weakness (HP:0009027)2.20346833
84Decreased motor nerve conduction velocity (HP:0003431)2.18436060
85Male infertility (HP:0003251)2.17479835
86Nuclear cataract (HP:0100018)2.16924110
873-Methylglutaconic aciduria (HP:0003535)2.16735200
88Dysmetria (HP:0001310)2.16133823
89Difficulty running (HP:0009046)2.14592500
90Neonatal hypoglycemia (HP:0001998)2.13211302
91Ankle clonus (HP:0011448)2.12172729
92Drooling (HP:0002307)2.11207572
93Excessive salivation (HP:0003781)2.11207572
94Split foot (HP:0001839)2.10638402
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09788599
96Degeneration of the lateral corticospinal tracts (HP:0002314)2.09788599
97Increased intramyocellular lipid droplets (HP:0012240)2.09334243
98Obstructive lung disease (HP:0006536)2.09167220
99Chronic obstructive pulmonary disease (HP:0006510)2.09167220
100Scanning speech (HP:0002168)2.08029824
101Hemiparesis (HP:0001269)2.07993768
102Concave nail (HP:0001598)2.07102739
103Obstructive sleep apnea (HP:0002870)2.06695246
104Inability to walk (HP:0002540)2.05819583
105Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04286250
106Anxiety (HP:0000739)2.03615191
107Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02521409
108Abnormality of reticulocytes (HP:0004312)2.02515037
109Depression (HP:0000716)2.02294964
110Exertional dyspnea (HP:0002875)2.01958575
111Thrombocytosis (HP:0001894)2.01888099
112Segmental peripheral demyelination/remyelination (HP:0003481)2.01747302
113Reticulocytopenia (HP:0001896)2.01458512
114Abnormality of liposaccharide metabolism (HP:0010968)2.00755310
115Abnormality of glycosphingolipid metabolism (HP:0004343)2.00755310
116Abnormality of glycolipid metabolism (HP:0010969)2.00755310
117Abnormality of the corticospinal tract (HP:0002492)2.00540760
118Abnormality of dental color (HP:0011073)2.00525316
119Leukodystrophy (HP:0002415)1.98985865
120Distal lower limb amyotrophy (HP:0008944)1.98233750
121Hyperacusis (HP:0010780)1.94873178
122Abnormality of the foot musculature (HP:0001436)1.94406601
123Abnormality of renal resorption (HP:0011038)1.94170995
124Urinary bladder sphincter dysfunction (HP:0002839)1.94107267
125Testicular atrophy (HP:0000029)1.92641415
126Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92241060
127Dysmetric saccades (HP:0000641)1.91442152
128X-linked dominant inheritance (HP:0001423)1.90311869
129Attenuation of retinal blood vessels (HP:0007843)1.90174139
130Hyperphosphatemia (HP:0002905)1.90110714
131Ragged-red muscle fibers (HP:0003200)1.89017355
132Reticulocytosis (HP:0001923)1.88702108
133Limb dystonia (HP:0002451)1.87571898
134Cholelithiasis (HP:0001081)1.87424641
135Optic nerve hypoplasia (HP:0000609)1.86486502
136Exercise intolerance (HP:0003546)1.85065846
137Esotropia (HP:0000565)1.85030286
138Ulnar claw (HP:0001178)1.84179009
139Nonprogressive disorder (HP:0003680)1.83818110
140Neurofibrillary tangles (HP:0002185)1.83591666
141Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83007670
142Distal lower limb muscle weakness (HP:0009053)1.82725125
143Urinary urgency (HP:0000012)1.82421842
144Slow saccadic eye movements (HP:0000514)1.82256862
145Septo-optic dysplasia (HP:0100842)1.81938386
146Purpura (HP:0000979)1.81696038
147Thickened helices (HP:0000391)1.81489501
148Progressive external ophthalmoplegia (HP:0000590)1.80712549
149Cerebral inclusion bodies (HP:0100314)1.80520530
150Sleep apnea (HP:0010535)1.79622810
151Hypercalcemia (HP:0003072)1.79008928
152Pelvic girdle muscle weakness (HP:0003749)1.78137654
153Vertebral compression fractures (HP:0002953)1.77917410
154Hypoparathyroidism (HP:0000829)1.77475148
155Personality changes (HP:0000751)1.76960215
156Generalized myoclonic seizures (HP:0002123)1.76788125
157Respiratory failure (HP:0002878)1.75632559
158Cellulitis (HP:0100658)1.73615392
159Hydroureter (HP:0000072)1.73138505
160Paralysis (HP:0003470)1.72682329
161Loss of speech (HP:0002371)1.72656265
162Medial flaring of the eyebrow (HP:0010747)1.72569291
163Abnormality of the septum pellucidum (HP:0007375)1.71498829
164Abnormal hemoglobin (HP:0011902)1.70813075
165Absent septum pellucidum (HP:0001331)1.70250294
166Fetal akinesia sequence (HP:0001989)1.69772100
167Tetraplegia (HP:0002445)1.69699179
168Diastasis recti (HP:0001540)1.69689297
169Increased connective tissue (HP:0009025)1.67965496
170Back pain (HP:0003418)1.67818538
171Hyperthyroidism (HP:0000836)1.67714453
172Abnormality of magnesium homeostasis (HP:0004921)1.67472597
173Myopathic facies (HP:0002058)1.66345905
174Pallor (HP:0000980)1.65331355
175Conical tooth (HP:0000698)1.65167921
176Polygenic inheritance (HP:0010982)1.64692551
177Urinary incontinence (HP:0000020)1.62426802
178Nasal polyposis (HP:0100582)1.62050233
179Abnormality of the heme biosynthetic pathway (HP:0010472)1.59842763
180Microcytic anemia (HP:0001935)1.57925066
181Spastic tetraparesis (HP:0001285)1.57363334
182Urticaria (HP:0001025)1.56706966
183Orthostatic hypotension (HP:0001278)1.56612091
184Calcaneovalgus deformity (HP:0001848)1.55916571
185Increased cerebral lipofuscin (HP:0011813)1.53946255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.28267188
2TNIK4.08247256
3EPHA43.67631649
4NTRK33.06426278
5MAP3K122.82686666
6PNCK2.68669999
7TRIB32.65754386
8RIPK42.65692826
9SMG12.64740610
10MAP2K72.37573068
11CDK192.29835750
12ICK2.23914777
13FES2.19090328
14EPHB22.10291511
15LATS22.04001548
16MAP3K112.00642555
17MKNK21.97988609
18FGR1.95724183
19MUSK1.93751159
20IRAK31.93112522
21CDK121.74756996
22STK161.72200249
23MAP3K41.69265731
24GRK51.67618036
25MAP2K31.65742889
26NME11.65726940
27SCYL21.60554424
28ARAF1.55416455
29STK391.52783656
30OXSR11.50171508
31PLK21.49815948
32GRK71.44990009
33MINK11.44643503
34BMPR21.44223386
35KSR21.41261026
36STK241.34393575
37DYRK1B1.33444760
38CAMK2B1.33278574
39IRAK41.31307082
40MKNK11.29848513
41TYRO31.29452467
42UHMK11.28813981
43TLK11.26372136
44MAP3K11.24749662
45TAOK21.23219942
46MAP3K91.21870174
47TESK11.20623895
48CDC71.19648494
49MAP3K61.17204624
50MARK21.13853613
51ALK1.13715974
52MARK11.13281252
53RPS6KB21.12126878
54RIPK11.11010665
55CAMK2A1.10786041
56MAPK131.07702859
57DAPK11.07238554
58EIF2AK11.06397924
59CLK11.05141366
60CSK1.04972834
61MOS1.04238540
62CAMKK11.03998659
63SIK11.01697235
64PRPF4B0.99622798
65LRRK20.99193752
66MAP2K40.95379685
67MST40.93226393
68MAPKAPK50.92896442
69DAPK20.92844757
70TAOK10.89634745
71NME20.89158275
72NTRK20.89033891
73SGK30.88441321
74ADRBK20.87892182
75CDK50.87476164
76SIK20.84241428
77CAMK10.83994963
78NLK0.83495602
79PBK0.81462281
80PRKCG0.81160600
81VRK10.77962861
82CDK140.77852472
83DYRK1A0.77641531
84PTK2B0.77033748
85SRPK10.76181834
86RAF10.75232638
87BLK0.74892957
88DMPK0.74098900
89FER0.72431598
90NTRK10.72112911
91RPS6KA40.71574632
92BCR0.70461044
93GRK60.69637553
94PRKD20.69199597
95MAP3K140.67882643
96PDPK10.67803436
97CAMK2D0.65537726
98STK110.65035466
99MAP3K30.64084906
100CDK180.63282406
101CDK150.63154475
102CDK11A0.63058706
103BMX0.61518972
104YES10.61426759
105FGFR40.61361900
106DYRK30.61269104
107ZAP700.60645919
108AURKA0.59529425
109CDK40.59261806
110BRAF0.59148116
111EIF2AK30.59094064
112MAP3K130.59072437
113CDK60.59043701
114PKN10.58631017
115PTK60.58327128
116ADRBK10.57553879
117ABL20.57242448
118ROCK20.57091694
119MAP4K10.55992511
120BMPR1B0.55347591
121WEE10.54327128
122TBK10.53894239
123BUB10.53625370
124IRAK20.52544946
125CSNK1G20.51274776
126RPS6KL10.50608813
127RPS6KC10.50608813
128EEF2K0.50522131
129PRKCE0.50389340
130CAMK2G0.50345103
131RPS6KA20.50289413
132CSNK1G30.49901410
133PKN20.49544814
134TAF10.48704027
135NEK60.48530965
136CAMKK20.48049178
137DAPK30.47428021
138ERN10.46634175
139TYK20.46161186
140VRK20.46113931
141TNK20.45941896
142WNK40.45699008
143LIMK10.45684239
144MAP3K80.45586366
145PAK60.45462332
146MAPK120.44980972
147JAK20.44813137
148STK380.43491333
149KSR10.42147704
150SGK10.41623737
151ILK0.41443603
152TESK20.41109013
153WNK10.40423800
154PDK10.39043779
155RET0.38543578
156RPS6KA10.37958809
157DYRK20.37861285
158CDK30.37646607
159CSNK1G10.37532345
160PRKACA0.37011271
161IRAK10.35833963
162PIM20.35648956
163GRK10.34769322
164EIF2AK20.34265764
165PRKG10.31646578
166CSNK1E0.31231831

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.99677683
2Oxidative phosphorylation_Homo sapiens_hsa001903.49716877
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.18935757
4Ribosome_Homo sapiens_hsa030103.07778657
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58992497
6Parkinsons disease_Homo sapiens_hsa050122.57389657
7Alzheimers disease_Homo sapiens_hsa050102.48439610
8Glutamatergic synapse_Homo sapiens_hsa047242.28682927
9Phototransduction_Homo sapiens_hsa047442.27919523
10Synaptic vesicle cycle_Homo sapiens_hsa047212.22676011
11Long-term potentiation_Homo sapiens_hsa047202.22224705
12Morphine addiction_Homo sapiens_hsa050322.15095043
13Amphetamine addiction_Homo sapiens_hsa050312.13772626
14GABAergic synapse_Homo sapiens_hsa047272.12221064
15Huntingtons disease_Homo sapiens_hsa050162.04435869
16Circadian entrainment_Homo sapiens_hsa047132.01757630
17Serotonergic synapse_Homo sapiens_hsa047262.00414254
18Long-term depression_Homo sapiens_hsa047301.97401226
19Collecting duct acid secretion_Homo sapiens_hsa049661.94356762
20Non-small cell lung cancer_Homo sapiens_hsa052231.88017681
21Dopaminergic synapse_Homo sapiens_hsa047281.83538007
22Pancreatic cancer_Homo sapiens_hsa052121.81910449
23Taste transduction_Homo sapiens_hsa047421.81836140
24Salivary secretion_Homo sapiens_hsa049701.78043273
25B cell receptor signaling pathway_Homo sapiens_hsa046621.75282434
26Chronic myeloid leukemia_Homo sapiens_hsa052201.72091968
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.71266285
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69757514
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.68953734
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67484521
31Cardiac muscle contraction_Homo sapiens_hsa042601.66549038
32Olfactory transduction_Homo sapiens_hsa047401.65850106
33Endometrial cancer_Homo sapiens_hsa052131.59988381
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50978652
35Prion diseases_Homo sapiens_hsa050201.45869890
36Calcium signaling pathway_Homo sapiens_hsa040201.45518078
37Renin secretion_Homo sapiens_hsa049241.43232613
38Osteoclast differentiation_Homo sapiens_hsa043801.40272819
39Protein export_Homo sapiens_hsa030601.40043206
40Acute myeloid leukemia_Homo sapiens_hsa052211.38052664
41Salmonella infection_Homo sapiens_hsa051321.37520014
42Cholinergic synapse_Homo sapiens_hsa047251.37214354
43RNA polymerase_Homo sapiens_hsa030201.36986422
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36028660
45Endocytosis_Homo sapiens_hsa041441.34643119
46Gastric acid secretion_Homo sapiens_hsa049711.29897517
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28317528
48Bladder cancer_Homo sapiens_hsa052191.26288129
49Notch signaling pathway_Homo sapiens_hsa043301.25358374
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.25231891
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23509783
52Vibrio cholerae infection_Homo sapiens_hsa051101.21634969
53Oxytocin signaling pathway_Homo sapiens_hsa049211.21274474
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20430312
55Cocaine addiction_Homo sapiens_hsa050301.20146778
56Axon guidance_Homo sapiens_hsa043601.18511307
57Shigellosis_Homo sapiens_hsa051311.18405460
58Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15836693
59HIF-1 signaling pathway_Homo sapiens_hsa040661.13330078
60Phagosome_Homo sapiens_hsa041451.13321823
61Lysosome_Homo sapiens_hsa041421.11382566
62Central carbon metabolism in cancer_Homo sapiens_hsa052301.10961507
63Insulin signaling pathway_Homo sapiens_hsa049101.08185640
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05864337
65Melanogenesis_Homo sapiens_hsa049161.05388308
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04917175
67Colorectal cancer_Homo sapiens_hsa052101.04769442
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04500075
69Tuberculosis_Homo sapiens_hsa051521.02870951
70Proteasome_Homo sapiens_hsa030501.02240666
71GnRH signaling pathway_Homo sapiens_hsa049121.01086629
72Insulin secretion_Homo sapiens_hsa049111.01014524
73T cell receptor signaling pathway_Homo sapiens_hsa046600.99025674
74Gap junction_Homo sapiens_hsa045400.95059597
75Chemokine signaling pathway_Homo sapiens_hsa040620.94548117
76Hepatitis B_Homo sapiens_hsa051610.93889444
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92414917
78Prolactin signaling pathway_Homo sapiens_hsa049170.91611797
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90935057
80Ether lipid metabolism_Homo sapiens_hsa005650.90096866
81cAMP signaling pathway_Homo sapiens_hsa040240.89305128
82mRNA surveillance pathway_Homo sapiens_hsa030150.87745758
83Apoptosis_Homo sapiens_hsa042100.86938330
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85395483
85Hepatitis C_Homo sapiens_hsa051600.84980364
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84475467
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83472726
88mTOR signaling pathway_Homo sapiens_hsa041500.82738233
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82735547
90Wnt signaling pathway_Homo sapiens_hsa043100.82327534
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81534628
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80994788
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.80595893
94Inositol phosphate metabolism_Homo sapiens_hsa005620.78037181
95Pentose phosphate pathway_Homo sapiens_hsa000300.77011451
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76166815
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75965230
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75414153
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75236841
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.75221338
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.73952067
102Leishmaniasis_Homo sapiens_hsa051400.73094535
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73064711
104Pancreatic secretion_Homo sapiens_hsa049720.71477312
105Oocyte meiosis_Homo sapiens_hsa041140.71327588
106Influenza A_Homo sapiens_hsa051640.68859776
107Rheumatoid arthritis_Homo sapiens_hsa053230.67669491
108Sphingolipid metabolism_Homo sapiens_hsa006000.67541063
109Folate biosynthesis_Homo sapiens_hsa007900.65894948
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65193782
111Viral carcinogenesis_Homo sapiens_hsa052030.65048113
112Epstein-Barr virus infection_Homo sapiens_hsa051690.64722594
113Ras signaling pathway_Homo sapiens_hsa040140.64669986
114* Spliceosome_Homo sapiens_hsa030400.64338403
115Measles_Homo sapiens_hsa051620.63323991
116Alcoholism_Homo sapiens_hsa050340.62857707
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62508734
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62134432
119Other glycan degradation_Homo sapiens_hsa005110.61821080
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61371478
121ErbB signaling pathway_Homo sapiens_hsa040120.60995774
122African trypanosomiasis_Homo sapiens_hsa051430.58642035
123Adherens junction_Homo sapiens_hsa045200.57998838
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55075945
125Legionellosis_Homo sapiens_hsa051340.54350189
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54242860
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53857639
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53556057
129Basal transcription factors_Homo sapiens_hsa030220.53055718
130Homologous recombination_Homo sapiens_hsa034400.52486682
131Prostate cancer_Homo sapiens_hsa052150.52382482
132Estrogen signaling pathway_Homo sapiens_hsa049150.52116578
133Choline metabolism in cancer_Homo sapiens_hsa052310.51641433
134Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50845800
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.48687819
136AMPK signaling pathway_Homo sapiens_hsa041520.48055274
137Purine metabolism_Homo sapiens_hsa002300.47464194
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46880898
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.46652044
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45517295
141Proteoglycans in cancer_Homo sapiens_hsa052050.45459906
142Type II diabetes mellitus_Homo sapiens_hsa049300.44817025
143Malaria_Homo sapiens_hsa051440.44048728
144TNF signaling pathway_Homo sapiens_hsa046680.44027778
145Fructose and mannose metabolism_Homo sapiens_hsa000510.43826283
146Pyrimidine metabolism_Homo sapiens_hsa002400.40215504
147Glioma_Homo sapiens_hsa052140.40114950
148MAPK signaling pathway_Homo sapiens_hsa040100.38035808
149Thyroid cancer_Homo sapiens_hsa052160.37061366
150VEGF signaling pathway_Homo sapiens_hsa043700.36634411
151Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33713568
152Rap1 signaling pathway_Homo sapiens_hsa040150.31178408
153Thyroid hormone synthesis_Homo sapiens_hsa049180.28862115
154Nucleotide excision repair_Homo sapiens_hsa034200.28827332
155Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28473800
156Autoimmune thyroid disease_Homo sapiens_hsa053200.25209279
157Melanoma_Homo sapiens_hsa052180.24602560
158Arachidonic acid metabolism_Homo sapiens_hsa005900.24524569
159Dorso-ventral axis formation_Homo sapiens_hsa043200.23645938
160Fanconi anemia pathway_Homo sapiens_hsa034600.22588779
161Type I diabetes mellitus_Homo sapiens_hsa049400.21722463
162Asthma_Homo sapiens_hsa053100.20123027
163Fatty acid elongation_Homo sapiens_hsa000620.19675079
164Mineral absorption_Homo sapiens_hsa049780.18826690
165Renal cell carcinoma_Homo sapiens_hsa052110.18634649
166DNA replication_Homo sapiens_hsa030300.18581643

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