ZMAT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.44025965
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.11222752
3collagen fibril organization (GO:0030199)4.00571006
4chondrocyte proliferation (GO:0035988)3.96291111
5locomotory exploration behavior (GO:0035641)3.88391485
6glutamate secretion (GO:0014047)3.80348501
7synaptic vesicle exocytosis (GO:0016079)3.74107291
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.69000092
9endodermal cell differentiation (GO:0035987)3.68927515
10vocalization behavior (GO:0071625)3.60489185
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.57527096
12pericardium development (GO:0060039)3.55127248
13dermatan sulfate biosynthetic process (GO:0030208)3.53234493
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.49044703
15cell adhesion mediated by integrin (GO:0033627)3.45084481
16layer formation in cerebral cortex (GO:0021819)3.44730198
17sequestering of extracellular ligand from receptor (GO:0035581)3.31273879
18synaptic vesicle docking involved in exocytosis (GO:0016081)3.30384737
19protein localization to synapse (GO:0035418)3.29524961
20dermatan sulfate metabolic process (GO:0030205)3.23544627
21innervation (GO:0060384)3.20506734
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.16002091
23proline transport (GO:0015824)3.15923562
24cell migration in hindbrain (GO:0021535)3.15590970
25neuronal action potential propagation (GO:0019227)3.14430550
26regulation of glutamate receptor signaling pathway (GO:1900449)3.13199099
27pre-miRNA processing (GO:0031054)3.12019796
28blood vessel maturation (GO:0001955)3.11378428
29dendritic spine morphogenesis (GO:0060997)3.10827952
30regulation of synaptic vesicle exocytosis (GO:2000300)3.09089316
31negative regulation of osteoblast proliferation (GO:0033689)3.07401063
32regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.06767948
33mesenchymal-epithelial cell signaling (GO:0060638)3.00362171
34exploration behavior (GO:0035640)2.98123609
35bone trabecula formation (GO:0060346)2.97087986
36neuron cell-cell adhesion (GO:0007158)2.96240141
37chondrocyte development (GO:0002063)2.95175075
38neuromuscular process controlling balance (GO:0050885)2.91503263
39cerebellar Purkinje cell differentiation (GO:0021702)2.87896659
40neurotransmitter secretion (GO:0007269)2.85913454
41gamma-aminobutyric acid signaling pathway (GO:0007214)2.83991363
42regulation of long-term neuronal synaptic plasticity (GO:0048169)2.83246033
43skin morphogenesis (GO:0043589)2.82596123
44regulation of axon extension involved in axon guidance (GO:0048841)2.80564418
45glutamate receptor signaling pathway (GO:0007215)2.79793548
46axonal fasciculation (GO:0007413)2.79730516
47protein heterotrimerization (GO:0070208)2.76713832
48synaptic transmission, glutamatergic (GO:0035249)2.76688877
49cellular response to vitamin (GO:0071295)2.75712199
50cell migration involved in heart development (GO:0060973)2.75337296
51regulation of neuronal synaptic plasticity (GO:0048168)2.75166852
52smooth muscle tissue development (GO:0048745)2.73928598
53neuron-neuron synaptic transmission (GO:0007270)2.72516683
54glomerular basement membrane development (GO:0032836)2.70166046
55synaptic vesicle endocytosis (GO:0048488)2.70157478
56polarized epithelial cell differentiation (GO:0030859)2.67728296
57kidney mesenchyme development (GO:0072074)2.67692187
58neuron recognition (GO:0008038)2.67120127
59negative regulation of chondrocyte differentiation (GO:0032331)2.66813066
60regulation of dendritic spine morphogenesis (GO:0061001)2.66086757
61inner ear receptor cell development (GO:0060119)2.65375807
62extracellular matrix assembly (GO:0085029)2.65120716
63protein localization to endosome (GO:0036010)2.64564517
64suckling behavior (GO:0001967)2.64362348
65dendrite morphogenesis (GO:0048813)2.64090416
66positive regulation of dendritic spine morphogenesis (GO:0061003)2.63784805
67positive regulation of cardiac muscle hypertrophy (GO:0010613)2.63396375
68positive regulation of muscle hypertrophy (GO:0014742)2.63396375
69positive regulation of axon extension (GO:0045773)2.63067543
70negative regulation of hormone biosynthetic process (GO:0032353)2.61447480
71cytoskeletal anchoring at plasma membrane (GO:0007016)2.61217767
72dendritic spine organization (GO:0097061)2.60428715
73postsynaptic membrane organization (GO:0001941)2.59907847
74anterior/posterior axis specification, embryo (GO:0008595)2.59611181
75regulation of posttranscriptional gene silencing (GO:0060147)2.57373319
76regulation of gene silencing by miRNA (GO:0060964)2.57373319
77regulation of gene silencing by RNA (GO:0060966)2.57373319
78negative regulation of neurotransmitter secretion (GO:0046929)2.56372446
79transmission of nerve impulse (GO:0019226)2.55442753
80gamma-aminobutyric acid transport (GO:0015812)2.53180677
81negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.52827188
82metanephric mesenchyme development (GO:0072075)2.52393690
83sodium ion export (GO:0071436)2.51373463
84neuromuscular process controlling posture (GO:0050884)2.51154742
85response to histamine (GO:0034776)2.51024207
86cellular potassium ion homeostasis (GO:0030007)2.50695944
87retina vasculature morphogenesis in camera-type eye (GO:0061299)2.48908205
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.48497491
89substrate adhesion-dependent cell spreading (GO:0034446)2.48352781
90positive regulation of synapse maturation (GO:0090129)2.48036582
91establishment of apical/basal cell polarity (GO:0035089)2.46248536
92regulation of synaptic plasticity (GO:0048167)2.45919082
93positive regulation of fibroblast migration (GO:0010763)2.45694428
94venous blood vessel morphogenesis (GO:0048845)2.45616990
95membrane assembly (GO:0071709)2.44967109
96L-amino acid import (GO:0043092)2.44556816
97neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.44275054
98regulation of synaptic vesicle transport (GO:1902803)2.43665514
99hypotonic response (GO:0006971)2.43268465
100neuromuscular process (GO:0050905)2.43182772
101regulation of excitatory postsynaptic membrane potential (GO:0060079)2.43133623
102long-term synaptic potentiation (GO:0060291)2.42196875
103negative regulation of axon extension involved in axon guidance (GO:0048843)2.42101327
104establishment or maintenance of monopolar cell polarity (GO:0061339)2.41844041
105establishment of monopolar cell polarity (GO:0061162)2.41844041
106regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.41830033
107cell-substrate junction assembly (GO:0007044)2.41658367
108behavioral defense response (GO:0002209)2.40712851
109behavioral fear response (GO:0001662)2.40712851
110platelet-derived growth factor receptor signaling pathway (GO:0048008)2.40235630
111collagen metabolic process (GO:0032963)2.40188337
112peptidyl-arginine omega-N-methylation (GO:0035247)2.39862602
113paraxial mesoderm development (GO:0048339)2.39098262
114cellular response to vitamin D (GO:0071305)2.39008695
115cochlea development (GO:0090102)2.38999281
116regulation of postsynaptic membrane potential (GO:0060078)2.38885483
117histone H4-K12 acetylation (GO:0043983)2.38875177
118long-term memory (GO:0007616)2.37764188
119heterochromatin organization (GO:0070828)2.36717453
120regulation of axon guidance (GO:1902667)2.36024925
121artery development (GO:0060840)2.35773533
122chondroitin sulfate biosynthetic process (GO:0030206)2.34945409
123axon extension (GO:0048675)2.34838233
124peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.34818867
125vesicle transport along microtubule (GO:0047496)2.34587742
126collagen catabolic process (GO:0030574)2.34086985
127regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.34066494
128negative regulation of anoikis (GO:2000811)2.33962658
129regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.33945543
130wound healing, spreading of epidermal cells (GO:0035313)2.33705572
131regulation of clathrin-mediated endocytosis (GO:2000369)2.32923899
132negative regulation of synaptic transmission, GABAergic (GO:0032229)2.32684650
133regulation of osteoblast proliferation (GO:0033688)2.32074714
134neurotransmitter transport (GO:0006836)2.31838123
135central nervous system projection neuron axonogenesis (GO:0021952)2.31371564
136endocytic recycling (GO:0032456)2.29689461
137SMAD protein complex assembly (GO:0007183)2.29560422
138cerebellar granule cell differentiation (GO:0021707)2.29057074
139chondroitin sulfate catabolic process (GO:0030207)2.28702796
140heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.28528234
141positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.28326487
142peptidyl-arginine N-methylation (GO:0035246)2.28233412
143peptidyl-arginine methylation (GO:0018216)2.28233412
144positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.28091279
145auditory behavior (GO:0031223)2.27869618
146regulation of early endosome to late endosome transport (GO:2000641)2.27443470
147glycine transport (GO:0015816)2.26576109
148positive regulation of osteoblast proliferation (GO:0033690)2.25846629
149amino acid import (GO:0043090)2.25292501
150regulation of extracellular matrix disassembly (GO:0010715)2.25150280
151regulation of glucocorticoid metabolic process (GO:0031943)2.25079825
152neuronal ion channel clustering (GO:0045161)2.24780996
153neuromuscular synaptic transmission (GO:0007274)2.24735631
154cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.24306637
155positive regulation of synapse assembly (GO:0051965)2.23746148
156regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.23636541
157astrocyte development (GO:0014002)2.23168355
158hippo signaling (GO:0035329)2.22716401
159positive regulation of macrophage cytokine production (GO:0060907)2.22391105
160planar cell polarity pathway involved in neural tube closure (GO:0090179)2.22269294
161membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.22078031
162cortical actin cytoskeleton organization (GO:0030866)2.22013413
163regulation of synaptic transmission, glutamatergic (GO:0051966)2.22012903
164relaxation of cardiac muscle (GO:0055119)2.21768983
165establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.21461911
166import into cell (GO:0098657)2.18767979
167negative regulation of fatty acid transport (GO:2000192)2.18228307
168stress fiber assembly (GO:0043149)2.18087203
169extracellular fibril organization (GO:0043206)2.17665161
170lymphangiogenesis (GO:0001946)2.17643665
171regulation of fibroblast migration (GO:0010762)2.17028607
172regulation of cardiac muscle hypertrophy (GO:0010611)2.16598679
173multicellular organismal macromolecule metabolic process (GO:0044259)2.16258331
174chondroitin sulfate metabolic process (GO:0030204)2.16194758
175positive regulation of Rho protein signal transduction (GO:0035025)2.15828761
176negative regulation of protein localization to cell surface (GO:2000009)2.15635422
177negative chemotaxis (GO:0050919)2.15530754
178negative regulation of hormone metabolic process (GO:0032351)2.12404984
179presynaptic membrane assembly (GO:0097105)2.12362060
180regulation of muscle hypertrophy (GO:0014743)2.11591629
181hemidesmosome assembly (GO:0031581)2.10396563
182endocardial cushion development (GO:0003197)2.10325284
183cell communication by electrical coupling (GO:0010644)2.09771607
184sprouting angiogenesis (GO:0002040)2.08244782
185heparan sulfate proteoglycan metabolic process (GO:0030201)2.06834191

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.78654553
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.87919360
3SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.59379221
4GBX2_23144817_ChIP-Seq_PC3_Human2.48466745
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.36513528
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.30832254
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30568202
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.29149035
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20327784
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20327784
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18967796
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09947690
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.07249021
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.05713147
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.05280446
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.01679169
17SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.98469839
18CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.97612578
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97523694
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96691754
21NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.95220157
22NRF2_20460467_ChIP-Seq_MEFs_Mouse1.95220157
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95142717
24BRD4_25478319_ChIP-Seq_HGPS_Human1.93933747
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.92409326
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.92409326
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.92409326
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.91456089
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90151292
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.89731336
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.89635095
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.89092980
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87820683
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.86423286
35DROSHA_22980978_ChIP-Seq_HELA_Human1.81066666
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74985132
37* REST_21632747_ChIP-Seq_MESCs_Mouse1.74591099
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74270372
39CJUN_26792858_Chip-Seq_BT549_Human1.74122870
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.70565908
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69458195
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66114383
43AR_21572438_ChIP-Seq_LNCaP_Human1.65913998
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64649219
45* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63890461
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63123443
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.63113723
48TRIM28_21343339_ChIP-Seq_HEK293_Human1.61270808
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61196033
50CTNNB1_20460455_ChIP-Seq_HCT116_Human1.60922108
51* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60161914
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.59277513
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58489717
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58084193
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.56852792
56TP53_16413492_ChIP-PET_HCT116_Human1.54845960
57* TP53_20018659_ChIP-ChIP_R1E_Mouse1.54021149
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.53846658
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51651495
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.48222910
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.48023436
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.47675608
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.46915630
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44401534
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.43599262
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42741854
67SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.42648927
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38810479
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38748188
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.35935360
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34538184
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34337396
73NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.33215312
74SMAD4_21799915_ChIP-Seq_A2780_Human1.29735427
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28859513
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.28438798
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27626110
78TCF3_18692474_ChIP-Seq_MESCs_Mouse1.25930831
79NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.24331434
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.22732930
81REST_18959480_ChIP-ChIP_MESCs_Mouse1.21680622
82* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21387858
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.20938344
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20889475
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20201116
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20092093
87STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19675235
88* AR_19668381_ChIP-Seq_PC3_Human1.18607636
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18184939
90KDM2B_26808549_Chip-Seq_K562_Human1.17129865
91TBX3_20139965_ChIP-Seq_ESCs_Mouse1.16923618
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16727479
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16602418
94TBX3_20139965_ChIP-Seq_MESCs_Mouse1.16597843
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16491740
96* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16215485
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16177771
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15514627
99TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.14731349
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14630183
101POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.14294093
102FLI1_27457419_Chip-Seq_LIVER_Mouse1.13349555
103STAT3_23295773_ChIP-Seq_U87_Human1.13090482
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11255529
105NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11245201
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10942759
107SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10634697
108DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09565555
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09227415
110SOX2_21211035_ChIP-Seq_LN229_Gbm1.08851283
111AHR_22903824_ChIP-Seq_MCF-7_Human1.08825333
112* P300_19829295_ChIP-Seq_ESCs_Human1.07945214
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07925787
114PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.07010993
115RNF2_27304074_Chip-Seq_NSC_Mouse1.06831721
116POU5F1_16518401_ChIP-PET_MESCs_Mouse1.06507640
117SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06040178
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05795590
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.05646779
120* TP53_18474530_ChIP-ChIP_U2OS_Human1.05280582
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05137635
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04982273
123CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04738699
124SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04500920
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04201133
126* TP53_22127205_ChIP-Seq_IMR90_Human1.03725630
127TP63_23658742_ChIP-Seq_EP156T_Human1.03719716
128EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03527576
129BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03421907
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03027740
131PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02528417
132FUS_26573619_Chip-Seq_HEK293_Human1.01788931
133WT1_19549856_ChIP-ChIP_CCG9911_Human1.01370416
134SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01329058
135CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01038035
136TCF4_23295773_ChIP-Seq_U87_Human1.00921097
137Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00831953
138SMAD3_21741376_ChIP-Seq_HESCs_Human1.00747966
139* SMAD3_21741376_ChIP-Seq_EPCs_Human1.00516945
140RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00312759
141* TP53_23651856_ChIP-Seq_MEFs_Mouse1.00204013
142ISL1_27105846_Chip-Seq_CPCs_Mouse1.00164818
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99766537
144TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99460979
145TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99318081
146POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99025913
147* KDM2B_26808549_Chip-Seq_REH_Human0.97922560
148P53_22387025_ChIP-Seq_ESCs_Mouse0.97746131
149EZH2_27294783_Chip-Seq_NPCs_Mouse0.93855862
150E2F1_18555785_Chip-Seq_ESCs_Mouse0.93425290

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.47944004
2MP0005275_abnormal_skin_tensile3.42842755
3MP0003279_aneurysm3.41451393
4MP0005257_abnormal_intraocular_pressure3.37067676
5MP0001958_emphysema3.14696970
6MP0005623_abnormal_meninges_morphology3.03504569
7MP0003635_abnormal_synaptic_transmissio2.70881531
8MP0004270_analgesia2.48625939
9MP0009046_muscle_twitch2.40040071
10MP0003880_abnormal_central_pattern2.17639431
11MP0003566_abnormal_cell_adhesion2.12326525
12MP0002063_abnormal_learning/memory/cond2.07799004
13MP0004858_abnormal_nervous_system2.04129904
14MP0002064_seizures2.02071362
15MP0006054_spinal_hemorrhage2.00895416
16MP0009745_abnormal_behavioral_response1.97928499
17MP0003283_abnormal_digestive_organ1.95741859
18MP0010368_abnormal_lymphatic_system1.95092083
19MP0001968_abnormal_touch/_nociception1.89483469
20MP0000013_abnormal_adipose_tissue1.82328945
21MP0000767_abnormal_smooth_muscle1.81190620
22MP0003122_maternal_imprinting1.80753466
23MP0001486_abnormal_startle_reflex1.78903169
24MP0002572_abnormal_emotion/affect_behav1.77783644
25MP0003950_abnormal_plasma_membrane1.70052904
26MP0002295_abnormal_pulmonary_circulatio1.69140803
27MP0000778_abnormal_nervous_system1.64742662
28MP0002734_abnormal_mechanical_nocicepti1.64295838
29MP0009384_cardiac_valve_regurgitation1.63051670
30MP0002877_abnormal_melanocyte_morpholog1.60356156
31MP0009780_abnormal_chondrocyte_physiolo1.59390510
32MP0002184_abnormal_innervation1.53265872
33MP0003941_abnormal_skin_development1.52667710
34MP0001188_hyperpigmentation1.50870157
35MP0002733_abnormal_thermal_nociception1.50231247
36MP0001299_abnormal_eye_distance/1.49541043
37MP0010030_abnormal_orbit_morphology1.47509327
38MP0002272_abnormal_nervous_system1.46083351
39MP0001542_abnormal_bone_strength1.43380306
40MP0005367_renal/urinary_system_phenotyp1.43228722
41MP0000516_abnormal_urinary_system1.43228722
42MP0005076_abnormal_cell_differentiation1.42756826
43MP0003385_abnormal_body_wall1.41029323
44MP0004133_heterotaxia1.40101991
45MP0002896_abnormal_bone_mineralization1.37895129
46MP0004233_abnormal_muscle_weight1.37297629
47MP0003705_abnormal_hypodermis_morpholog1.35721114
48MP0001879_abnormal_lymphatic_vessel1.35602543
49MP0003787_abnormal_imprinting1.34629677
50MP0000955_abnormal_spinal_cord1.33425650
51MP0002736_abnormal_nociception_after1.32321501
52MP0004811_abnormal_neuron_physiology1.30463091
53MP0001970_abnormal_pain_threshold1.29786516
54MP0003890_abnormal_embryonic-extraembry1.28198901
55MP0010352_gastrointestinal_tract_polyps1.27774438
56MP0002653_abnormal_ependyma_morphology1.26993423
57MP0001501_abnormal_sleep_pattern1.26458138
58MP0005394_taste/olfaction_phenotype1.22864799
59MP0005499_abnormal_olfactory_system1.22864799
60MP0002067_abnormal_sensory_capabilities1.22199095
61MP0005503_abnormal_tendon_morphology1.21737371
62MP0000534_abnormal_ureter_morphology1.21071987
63MP0004134_abnormal_chest_morphology1.19920978
64MP0008569_lethality_at_weaning1.19898663
65MP0003861_abnormal_nervous_system1.16583259
66MP0003121_genomic_imprinting1.16544167
67MP0001440_abnormal_grooming_behavior1.16403344
68MP0002882_abnormal_neuron_morphology1.15965427
69MP0002152_abnormal_brain_morphology1.15943467
70MP0003119_abnormal_digestive_system1.15904625
71MP0003755_abnormal_palate_morphology1.13039662
72MP0005423_abnormal_somatic_nervous1.12224213
73MP0005023_abnormal_wound_healing1.11965240
74MP0005248_abnormal_Harderian_gland1.11482391
75MP0005595_abnormal_vascular_smooth1.10720629
76MP0002557_abnormal_social/conspecific_i1.09747982
77MP0000569_abnormal_digit_pigmentation1.09083700
78MP0004142_abnormal_muscle_tone1.07208471
79MP0000537_abnormal_urethra_morphology1.06761631
80MP0000015_abnormal_ear_pigmentation1.05764610
81MP0001915_intracranial_hemorrhage1.05482728
82MP0010386_abnormal_urinary_bladder1.04829641
83MP0004885_abnormal_endolymph1.03574675
84MP0000428_abnormal_craniofacial_morphol1.02978250
85MP0004145_abnormal_muscle_electrophysio1.02443711
86MP0002735_abnormal_chemical_nociception1.02350076
87MP0005171_absent_coat_pigmentation1.02068520
88MP0003300_gastrointestinal_ulcer1.01461876
89MP0001348_abnormal_lacrimal_gland1.00664826
90MP0002233_abnormal_nose_morphology1.00603930
91MP0002177_abnormal_outer_ear1.00021288
92MP0003123_paternal_imprinting0.99552269
93MP0005174_abnormal_tail_pigmentation0.99068920
94MP0009250_abnormal_appendicular_skeleto0.98539638
95MP0000733_abnormal_muscle_development0.96301981
96MP0003942_abnormal_urinary_system0.96015419
97MP0002168_other_aberrant_phenotype0.95724776
98MP0003045_fibrosis0.95561807
99MP0000371_diluted_coat_color0.95122369
100MP0002249_abnormal_larynx_morphology0.94960413
101MP0008438_abnormal_cutaneous_collagen0.93267045
102MP0002066_abnormal_motor_capabilities/c0.93070755
103MP0002084_abnormal_developmental_patter0.92798150
104MP0000432_abnormal_head_morphology0.92605150
105MP0002116_abnormal_craniofacial_bone0.92314359
106MP0002751_abnormal_autonomic_nervous0.92161136
107MP0004084_abnormal_cardiac_muscle0.91900095
108MP0003935_abnormal_craniofacial_develop0.90446521
109MP0003091_abnormal_cell_migration0.90199165
110MP0002060_abnormal_skin_morphology0.89145945
111MP0001177_atelectasis0.88198092
112MP0005386_behavior/neurological_phenoty0.87580549
113MP0004924_abnormal_behavior0.87580549
114MP0002108_abnormal_muscle_morphology0.87133212
115MP0003633_abnormal_nervous_system0.86747762
116MP0000003_abnormal_adipose_tissue0.86725170
117MP0006072_abnormal_retinal_apoptosis0.85966973
118MP0005508_abnormal_skeleton_morphology0.85664179
119MP0001984_abnormal_olfaction0.85628359
120MP0005409_darkened_coat_color0.85475914
121MP0009053_abnormal_anal_canal0.85244778
122MP0000049_abnormal_middle_ear0.84508372
123MP0003937_abnormal_limbs/digits/tail_de0.83390647
124MP0002089_abnormal_postnatal_growth/wei0.83160758
125MP0000920_abnormal_myelination0.81859319
126MP0003634_abnormal_glial_cell0.81732829
127MP0006292_abnormal_olfactory_placode0.81676953
128MP0002128_abnormal_blood_circulation0.81112999
129MP0001293_anophthalmia0.80933809
130MP0002114_abnormal_axial_skeleton0.80245290
131MP0000631_abnormal_neuroendocrine_gland0.80179767
132MP0002081_perinatal_lethality0.80084267
133MP0004197_abnormal_fetal_growth/weight/0.79318779
134MP0002822_catalepsy0.77792627
135MP0004272_abnormal_basement_membrane0.76902004
136MP0008961_abnormal_basal_metabolism0.76825526
137MP0003868_abnormal_feces_composition0.75931708
138MP0003136_yellow_coat_color0.75319044
139MP0002752_abnormal_somatic_nervous0.74579162
140MP0003329_amyloid_beta_deposits0.73220487
141MP0005388_respiratory_system_phenotype0.72489596
142MP0002133_abnormal_respiratory_system0.72489596
143MP0000163_abnormal_cartilage_morphology0.69514262
144MP0000462_abnormal_digestive_system0.69289636
145MP0002115_abnormal_skeleton_extremities0.68608574
146MP0001270_distended_abdomen0.65870745
147MP0005197_abnormal_uvea_morphology0.62702735
148MP0001614_abnormal_blood_vessel0.62419723
149MP0000751_myopathy0.58447620
150MP0003183_abnormal_peptide_metabolism0.58133542
151MP0003631_nervous_system_phenotype0.58035188
152MP0002075_abnormal_coat/hair_pigmentati0.56734798
153MP0005621_abnormal_cell_physiology0.55849974
154MP0005193_abnormal_anterior_eye0.55157266
155MP0002909_abnormal_adrenal_gland0.55116562
156MP0000762_abnormal_tongue_morphology0.53334893
157MP0001175_abnormal_lung_morphology0.53177221

Predicted human phenotypes

RankGene SetZ-score
1Vascular tortuosity (HP:0004948)5.27388858
2Arterial tortuosity (HP:0005116)5.05578552
3Aortic dissection (HP:0002647)5.05524492
4Aortic aneurysm (HP:0004942)4.50361903
5Focal motor seizures (HP:0011153)3.79008272
6Soft skin (HP:0000977)3.78952198
7Neonatal short-limb short stature (HP:0008921)3.73943455
8Atrophic scars (HP:0001075)3.58707264
9Spondylolisthesis (HP:0003302)3.35724952
10Focal seizures (HP:0007359)3.32129851
11Mild short stature (HP:0003502)3.27291895
12Myokymia (HP:0002411)3.15623475
13Progressive cerebellar ataxia (HP:0002073)3.06639353
14Wormian bones (HP:0002645)3.06042736
15Broad metatarsal (HP:0001783)3.04275232
16Ankle contracture (HP:0006466)2.88385361
17Dilatation of the ascending aorta (HP:0005111)2.86146306
18Hypoplasia of the iris (HP:0007676)2.85649299
19Follicular hyperkeratosis (HP:0007502)2.81395293
20Action tremor (HP:0002345)2.78935764
21Mitral valve prolapse (HP:0001634)2.78729048
22Epileptic encephalopathy (HP:0200134)2.72853237
23Fragile skin (HP:0001030)2.65868863
24Mitral stenosis (HP:0001718)2.62620334
25Spinal rigidity (HP:0003306)2.59789019
26Febrile seizures (HP:0002373)2.56415638
27Wide anterior fontanel (HP:0000260)2.54008735
28Atonic seizures (HP:0010819)2.53630278
29Hyperextensible skin (HP:0000974)2.52047845
30Cervical subluxation (HP:0003308)2.50490258
31Protrusio acetabuli (HP:0003179)2.47604483
32Genetic anticipation (HP:0003743)2.46534463
33Shallow orbits (HP:0000586)2.43645886
34Abnormality of the astrocytes (HP:0100707)2.39644040
35Astrocytoma (HP:0009592)2.39644040
36Abnormality of the labia minora (HP:0012880)2.37008455
37Entropion (HP:0000621)2.36942746
38Peritonitis (HP:0002586)2.36508014
39Abnormality of the ischium (HP:0003174)2.35165325
40Dysdiadochokinesis (HP:0002075)2.33607985
41Aortic regurgitation (HP:0001659)2.32778985
42Vertebral arch anomaly (HP:0008438)2.30569947
43Blue sclerae (HP:0000592)2.29457884
44Mitral regurgitation (HP:0001653)2.27468694
45Visual hallucinations (HP:0002367)2.23796681
46Camptodactyly of toe (HP:0001836)2.22251536
47Ankyloglossia (HP:0010296)2.14983406
48Vertebral compression fractures (HP:0002953)2.14718897
49Limited hip movement (HP:0008800)2.13739408
50Hypoplastic ischia (HP:0003175)2.11903642
51Absence seizures (HP:0002121)2.11329790
52Joint laxity (HP:0001388)2.09648495
53Pulmonic stenosis (HP:0001642)2.08381313
54Macroorchidism (HP:0000053)2.07694053
55Genu recurvatum (HP:0002816)2.06956696
56Broad ribs (HP:0000885)2.03770439
57Aneurysm (HP:0002617)2.03583155
58Abnormality of the nasal septum (HP:0000419)2.01549151
59Emphysema (HP:0002097)2.00267093
60Impaired smooth pursuit (HP:0007772)1.98538420
61Aortic valve stenosis (HP:0001650)1.97140050
62Glioma (HP:0009733)1.96854918
63Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.96713984
64Cupped ribs (HP:0000887)1.95686342
65Annular pancreas (HP:0001734)1.95601008
66Increased variability in muscle fiber diameter (HP:0003557)1.94388328
67Dialeptic seizures (HP:0011146)1.94282193
68Spinal cord lesions (HP:0100561)1.92033649
69Syringomyelia (HP:0003396)1.92033649
70Striae distensae (HP:0001065)1.91149804
71Biconcave vertebral bodies (HP:0004586)1.88856780
72Type 1 muscle fiber predominance (HP:0003803)1.88469495
73Thoracolumbar scoliosis (HP:0002944)1.88321195
74Urinary bladder sphincter dysfunction (HP:0002839)1.88283972
75Knee flexion contracture (HP:0006380)1.87771443
76Slender build (HP:0001533)1.87550333
77Generalized tonic-clonic seizures (HP:0002069)1.87098028
78Bowel diverticulosis (HP:0005222)1.86156429
79Dysmetric saccades (HP:0000641)1.85950886
80Obstructive sleep apnea (HP:0002870)1.85825535
81Rib fusion (HP:0000902)1.85493327
82Pointed chin (HP:0000307)1.84799433
83Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.84627331
84Coronal craniosynostosis (HP:0004440)1.84571165
85Gaze-evoked nystagmus (HP:0000640)1.84262312
86Abnormality of the acetabulum (HP:0003170)1.84024613
87Renal duplication (HP:0000075)1.83283695
88Hypoventilation (HP:0002791)1.81938571
89Absent speech (HP:0001344)1.81794256
90Ectopia lentis (HP:0001083)1.81075476
91Premature rupture of membranes (HP:0001788)1.79780602
92Deviation of the hallux (HP:0010051)1.79007349
93Persistence of primary teeth (HP:0006335)1.78660617
94Hallux valgus (HP:0001822)1.77843722
95Abnormality of ocular smooth pursuit (HP:0000617)1.77649614
96Ulnar bowing (HP:0003031)1.77584291
97Lower limb amyotrophy (HP:0007210)1.77079393
98Osteoarthritis (HP:0002758)1.76811563
99Asymmetry of the thorax (HP:0001555)1.74118596
100Scanning speech (HP:0002168)1.73448063
101Ependymoma (HP:0002888)1.73278993
102Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.72493143
103Aqueductal stenosis (HP:0002410)1.72175560
104Joint contractures involving the joints of the feet (HP:0100492)1.72040151
105Flexion contracture of toe (HP:0005830)1.72040151
106Short humerus (HP:0005792)1.71301500
107Ovoid vertebral bodies (HP:0003300)1.70354313
108Termporal pattern (HP:0011008)1.70077578
109Insidious onset (HP:0003587)1.70077578
110Keratoconus (HP:0000563)1.70049713
111Increased corneal curvature (HP:0100692)1.70049713
112Congenital glaucoma (HP:0001087)1.69963348
113Abnormality of the frontal sinuses (HP:0002687)1.68371924
114Hemiparesis (HP:0001269)1.67535051
115Wrist flexion contracture (HP:0001239)1.67203850
116Narrow nasal bridge (HP:0000446)1.66256602
117Broad-based gait (HP:0002136)1.66161322
118Megalencephaly (HP:0001355)1.66112218
119Round face (HP:0000311)1.65136117
120Drooling (HP:0002307)1.64251969
121Excessive salivation (HP:0003781)1.64251969
122Abnormality of the epiphyses of the hand (HP:0005924)1.63893440
123Cubitus valgus (HP:0002967)1.63509121
124Abnormality of oral frenula (HP:0000190)1.63473264
125Osteolytic defects of the hand bones (HP:0009699)1.62591715
126Osteolytic defects of the phalanges of the hand (HP:0009771)1.62591715
127Narrow palate (HP:0000189)1.61670433
128Vitreoretinal degeneration (HP:0000655)1.60502561
129Buphthalmos (HP:0000557)1.60485334
130Truncal ataxia (HP:0002078)1.60158591
131Mesomelia (HP:0003027)1.59444459
132Bradycardia (HP:0001662)1.59272277
133Long toe (HP:0010511)1.58955813
134Amblyopia (HP:0000646)1.58103608
135Elbow flexion contracture (HP:0002987)1.57726466
136Impaired vibration sensation in the lower limbs (HP:0002166)1.57456945
137Bladder diverticulum (HP:0000015)1.56970686
138Broad long bones (HP:0005622)1.56788365
139Gastrointestinal stroma tumor (HP:0100723)1.56697110
140Flared iliac wings (HP:0002869)1.55759864
141Abnormality of dentin (HP:0010299)1.54898440
142Bronchomalacia (HP:0002780)1.53830423
143Dysmetria (HP:0001310)1.52871019
144Abnormality of abdominal situs (HP:0011620)1.52799228
145Abdominal situs inversus (HP:0003363)1.52799228
146Overgrowth (HP:0001548)1.52718341
147Neoplasm of the oral cavity (HP:0100649)1.52705573
148Heterotopia (HP:0002282)1.51366502
149Diplopia (HP:0000651)1.51274210
150Abnormality of binocular vision (HP:0011514)1.51274210
151Broad thumb (HP:0011304)1.50916162
152Neoplasm of the heart (HP:0100544)1.50862106
153Supernumerary ribs (HP:0005815)1.50362937
154Cerebral aneurysm (HP:0004944)1.47625679
155Infantile muscular hypotonia (HP:0008947)1.47478164
156Aplasia/hypoplasia of the humerus (HP:0006507)1.46760095
157Flat cornea (HP:0007720)1.46359143
158Distal lower limb amyotrophy (HP:0008944)1.46341746
159Hypercortisolism (HP:0001578)1.45008515
160Short 1st metacarpal (HP:0010034)1.44121833
161Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.44121833
162Cutaneous finger syndactyly (HP:0010554)1.42907092
163Increased number of teeth (HP:0011069)1.42867465
164Widely spaced teeth (HP:0000687)1.42167138
165Papilledema (HP:0001085)1.42143866
166Hypoplasia of the maxilla (HP:0000327)1.41285201
167Urethral obstruction (HP:0000796)1.40334972
168Depression (HP:0000716)1.39374953
169Anophthalmia (HP:0000528)1.38861708
170Sensory axonal neuropathy (HP:0003390)1.38514308
171Esophageal atresia (HP:0002032)1.38466835
172Gastroesophageal reflux (HP:0002020)1.37610741
173Absent frontal sinuses (HP:0002688)1.37581916
174Distal upper limb amyotrophy (HP:0007149)1.37194705
175Upper limb amyotrophy (HP:0009129)1.37194705
176Supranuclear gaze palsy (HP:0000605)1.36485268
177Omphalocele (HP:0001539)1.36275652
178Aplasia involving bones of the upper limbs (HP:0009823)1.36273750
179Aplasia of the phalanges of the hand (HP:0009802)1.36273750
180Aplasia involving bones of the extremities (HP:0009825)1.36273750
181Generalized hypotonia (HP:0001290)1.35895178
182Arnold-Chiari malformation (HP:0002308)1.35527496

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK93.88235060
2NTRK33.83938286
3MAP3K93.47119798
4CDK123.30838380
5EPHA42.80014028
6LATS22.74494487
7PAK62.40584360
8NTRK12.34383354
9CASK2.27227913
10DDR22.20787603
11MYLK2.18305987
12STK382.05234290
13MINK11.94385298
14MAP3K41.86688386
15NTRK21.79073767
16PRKD31.68896411
17TYRO31.65169903
18ALK1.64245522
19FRK1.58377500
20TGFBR21.54442593
21STK38L1.52709257
22FER1.51755498
23EPHA21.50785974
24PNCK1.47918604
25JAK11.45667788
26PLK21.40098573
27MARK11.39937273
28PAK31.37781453
29ICK1.35042224
30STK31.34313652
31LATS11.34219611
32FGFR31.33259614
33PDGFRA1.32614254
34AKT31.27804285
35WNK11.26171056
36CAMKK11.24628778
37PRPF4B1.23699016
38PTK21.22329633
39BMX1.17902364
40TRPM71.16312375
41GRK51.14635987
42CDK141.10393348
43CDK51.08971394
44UHMK11.04307665
45MAPK70.98054524
46ROCK10.97009797
47KSR10.96371958
48PAK20.93833211
49DMPK0.93418018
50KSR20.92476585
51STK240.91897822
52MAP3K20.90132953
53MAP2K70.89486500
54DAPK10.89201760
55DAPK20.89037308
56CDK150.88844906
57STK110.88723520
58BRD40.88242390
59CDK180.87865514
60BMPR20.86908834
61MAP3K130.86606024
62TAOK10.86068698
63FGFR40.85930072
64SCYL20.85243854
65TNK20.84834004
66CAMK1G0.82848588
67MAPK100.80996746
68TIE10.79945468
69MTOR0.79834061
70MKNK20.78663628
71MARK20.78383599
72PRKCG0.77971969
73MAP2K40.77370459
74CDK11A0.77083365
75PRKD20.76974687
76FGFR10.74583725
77CDC42BPA0.73546150
78CSNK1E0.71400144
79PIM20.70989743
80MET0.69583863
81SIK20.69097352
82CDK60.68540439
83EPHB20.68265455
84RIPK10.66095212
85MAP2K10.65834264
86STK390.63323901
87CAMK2A0.62976722
88SGK10.62920920
89MELK0.62721477
90PRKCE0.62604196
91BCR0.61771097
92LIMK10.59102804
93PRKCH0.58998879
94RET0.58823551
95TTN0.57712707
96ROCK20.57663686
97RPS6KA30.55448006
98TGFBR10.54085691
99SGK30.53325057
100KIT0.53084145
101INSR0.52258873
102CSNK1D0.50229257
103CSNK1A1L0.49900815
104CSNK1G20.49884738
105PDGFRB0.49285705
106TNIK0.49257906
107FGR0.48774888
108GSK3B0.48149701
109ADRBK10.47226238
110SGK20.46466728
111PLK30.46403345
112CDK70.46000521
113EEF2K0.45809311
114SGK2230.44465732
115SGK4940.44465732
116DAPK30.44269812
117PTK2B0.44142831
118CDK190.44079113
119MAPK130.43739667
120ERBB40.43710885
121CAMK1D0.41864726
122DYRK1A0.41509109
123MOS0.41465828
124CAMK2B0.41312213
125MAPK140.40752107
126RPS6KB10.40649730
127CAMKK20.40631613
128FGFR20.40213601
129EPHB10.40208234
130MAP3K70.39399656
131CAMK10.39179081
132RPS6KA20.38285094
133PRKD10.37612182
134FLT30.37306009
135RAF10.36409388
136PIK3CG0.36047552
137EPHA30.35903622
138MUSK0.35440842
139GSK3A0.35305589
140ABL10.35199161

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.79878208
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.11117584
3Synaptic vesicle cycle_Homo sapiens_hsa047212.05147592
4Long-term potentiation_Homo sapiens_hsa047202.00550624
5GABAergic synapse_Homo sapiens_hsa047271.85161284
6Glutamatergic synapse_Homo sapiens_hsa047241.84598741
7Circadian entrainment_Homo sapiens_hsa047131.82726942
8Amphetamine addiction_Homo sapiens_hsa050311.82302763
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77767974
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77070213
11Morphine addiction_Homo sapiens_hsa050321.69079714
12Salivary secretion_Homo sapiens_hsa049701.64363376
13Olfactory transduction_Homo sapiens_hsa047401.63696328
14Dopaminergic synapse_Homo sapiens_hsa047281.61145052
15Long-term depression_Homo sapiens_hsa047301.57976714
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52305862
17Insulin secretion_Homo sapiens_hsa049111.51738167
18Glioma_Homo sapiens_hsa052141.43070165
19Taste transduction_Homo sapiens_hsa047421.43046304
20Gap junction_Homo sapiens_hsa045401.41150620
21Axon guidance_Homo sapiens_hsa043601.39560915
22Gastric acid secretion_Homo sapiens_hsa049711.38849951
23Cholinergic synapse_Homo sapiens_hsa047251.38710152
24Cocaine addiction_Homo sapiens_hsa050301.38333554
25Serotonergic synapse_Homo sapiens_hsa047261.36758129
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35257736
27Oxytocin signaling pathway_Homo sapiens_hsa049211.35136019
28Hippo signaling pathway_Homo sapiens_hsa043901.32882393
29ErbB signaling pathway_Homo sapiens_hsa040121.29642555
30Melanogenesis_Homo sapiens_hsa049161.29575060
31Wnt signaling pathway_Homo sapiens_hsa043101.29475386
32Small cell lung cancer_Homo sapiens_hsa052221.28940609
33Protein digestion and absorption_Homo sapiens_hsa049741.25546533
34Hedgehog signaling pathway_Homo sapiens_hsa043401.24972368
35Estrogen signaling pathway_Homo sapiens_hsa049151.24793669
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22828590
37Dorso-ventral axis formation_Homo sapiens_hsa043201.22615043
38Renin secretion_Homo sapiens_hsa049241.18159002
39GnRH signaling pathway_Homo sapiens_hsa049121.17632845
40mTOR signaling pathway_Homo sapiens_hsa041501.15594406
41Amoebiasis_Homo sapiens_hsa051461.14048494
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11374113
43Basal cell carcinoma_Homo sapiens_hsa052171.11212938
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11010411
45Nitrogen metabolism_Homo sapiens_hsa009101.10216885
46MicroRNAs in cancer_Homo sapiens_hsa052061.05840127
47Calcium signaling pathway_Homo sapiens_hsa040201.05320091
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04987834
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04269409
50cAMP signaling pathway_Homo sapiens_hsa040241.03508721
51Melanoma_Homo sapiens_hsa052181.03191017
52Oocyte meiosis_Homo sapiens_hsa041140.99466666
53MAPK signaling pathway_Homo sapiens_hsa040100.98174196
54Rap1 signaling pathway_Homo sapiens_hsa040150.97586387
55Proteoglycans in cancer_Homo sapiens_hsa052050.97444278
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97036609
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96985007
58Dilated cardiomyopathy_Homo sapiens_hsa054140.96772413
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95662617
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.95034680
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94614039
62Bladder cancer_Homo sapiens_hsa052190.94249953
63Type II diabetes mellitus_Homo sapiens_hsa049300.93892197
64Adherens junction_Homo sapiens_hsa045200.93346038
65Platelet activation_Homo sapiens_hsa046110.93055816
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91315151
67Choline metabolism in cancer_Homo sapiens_hsa052310.90466697
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.89057518
69Prolactin signaling pathway_Homo sapiens_hsa049170.88949710
70Ras signaling pathway_Homo sapiens_hsa040140.86905053
71Pancreatic cancer_Homo sapiens_hsa052120.85103403
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84924331
73Focal adhesion_Homo sapiens_hsa045100.84347453
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83170710
75Tight junction_Homo sapiens_hsa045300.83089734
76Colorectal cancer_Homo sapiens_hsa052100.82408651
77Endometrial cancer_Homo sapiens_hsa052130.81929438
78Renal cell carcinoma_Homo sapiens_hsa052110.79594147
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78664670
80ECM-receptor interaction_Homo sapiens_hsa045120.76130221
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76039862
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.75658223
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.75463846
84TGF-beta signaling pathway_Homo sapiens_hsa043500.74394280
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74110497
86Prion diseases_Homo sapiens_hsa050200.73292149
87FoxO signaling pathway_Homo sapiens_hsa040680.73039541
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71794153
89VEGF signaling pathway_Homo sapiens_hsa043700.71123415
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71054920
91Alcoholism_Homo sapiens_hsa050340.69832189
92Thyroid hormone synthesis_Homo sapiens_hsa049180.68492347
93Prostate cancer_Homo sapiens_hsa052150.67304721
94* p53 signaling pathway_Homo sapiens_hsa041150.67032196
95Pancreatic secretion_Homo sapiens_hsa049720.66555388
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65821676
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65337096
98Chronic myeloid leukemia_Homo sapiens_hsa052200.64951961
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.64323755
100Pathways in cancer_Homo sapiens_hsa052000.64185594
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62516259
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.61393255
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60354729
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60108994
105Endocytosis_Homo sapiens_hsa041440.59664937
106B cell receptor signaling pathway_Homo sapiens_hsa046620.58508942
107Non-small cell lung cancer_Homo sapiens_hsa052230.58087423
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57559783
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56810449
110Inositol phosphate metabolism_Homo sapiens_hsa005620.56703036
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55123137
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54950202
113Circadian rhythm_Homo sapiens_hsa047100.54103884
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52073332
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.50905696

Most similar genes based on co-expression Upload to Enrichr

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