ZMAT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.14051628
2vocalization behavior (GO:0071625)6.05497366
3synaptic vesicle exocytosis (GO:0016079)5.90153481
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.87691779
5neuron cell-cell adhesion (GO:0007158)5.78635514
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.77887158
7glutamate secretion (GO:0014047)5.66719051
8protein localization to synapse (GO:0035418)5.46674779
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.44823639
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.42778754
11regulation of synaptic vesicle exocytosis (GO:2000300)5.20891309
12neuronal action potential propagation (GO:0019227)5.20653854
13regulation of glutamate receptor signaling pathway (GO:1900449)5.19249299
14presynaptic membrane assembly (GO:0097105)5.00930345
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.87307615
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.87231577
17neurotransmitter-gated ion channel clustering (GO:0072578)4.85856926
18synaptic vesicle maturation (GO:0016188)4.75709873
19locomotory exploration behavior (GO:0035641)4.70848767
20neurotransmitter secretion (GO:0007269)4.70233374
21regulation of synaptic vesicle transport (GO:1902803)4.65510216
22postsynaptic membrane organization (GO:0001941)4.58868979
23presynaptic membrane organization (GO:0097090)4.53988892
24glutamate receptor signaling pathway (GO:0007215)4.53730991
25synaptic transmission, glutamatergic (GO:0035249)4.50440722
26gamma-aminobutyric acid signaling pathway (GO:0007214)4.46230616
27neuron-neuron synaptic transmission (GO:0007270)4.44200775
28negative regulation of synaptic transmission, GABAergic (GO:0032229)4.34884368
29gamma-aminobutyric acid transport (GO:0015812)4.30654229
30response to histamine (GO:0034776)4.21658135
31positive regulation of synapse maturation (GO:0090129)4.19312201
32regulation of excitatory postsynaptic membrane potential (GO:0060079)4.13700421
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.07636209
34regulation of neuronal synaptic plasticity (GO:0048168)4.07354923
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.99047516
36positive regulation of membrane potential (GO:0045838)3.97402467
37regulation of postsynaptic membrane potential (GO:0060078)3.96923473
38exploration behavior (GO:0035640)3.93762787
39neurotransmitter transport (GO:0006836)3.83987511
40regulation of synaptic transmission, glutamatergic (GO:0051966)3.79392215
41behavioral response to nicotine (GO:0035095)3.77766402
42long-term synaptic potentiation (GO:0060291)3.77443048
43neuron recognition (GO:0008038)3.76503336
44long-term memory (GO:0007616)3.75608626
45regulation of neurotransmitter secretion (GO:0046928)3.67002717
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66460009
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.65230755
48regulation of synapse structural plasticity (GO:0051823)3.61094252
49regulation of synaptic plasticity (GO:0048167)3.58478643
50positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.57817011
51pyrimidine nucleobase catabolic process (GO:0006208)3.56789584
52proline transport (GO:0015824)3.56127266
53startle response (GO:0001964)3.53836236
54regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.53175013
55synaptic vesicle endocytosis (GO:0048488)3.51854238
56regulation of neurotransmitter levels (GO:0001505)3.51421568
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.50867009
58regulation of vesicle fusion (GO:0031338)3.50184076
59positive regulation of neurotransmitter secretion (GO:0001956)3.49810496
60cerebellar Purkinje cell differentiation (GO:0021702)3.49487066
61axonal fasciculation (GO:0007413)3.47250704
62positive regulation of neurotransmitter transport (GO:0051590)3.47049821
63cerebellar granule cell differentiation (GO:0021707)3.44974271
64regulation of synapse maturation (GO:0090128)3.44550587
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.43211685
66membrane depolarization (GO:0051899)3.38353794
67behavioral response to cocaine (GO:0048148)3.37735189
68regulation of neurotransmitter transport (GO:0051588)3.32711681
69regulation of glutamate secretion (GO:0014048)3.31626460
70positive regulation of synaptic transmission, GABAergic (GO:0032230)3.30689297
71fear response (GO:0042596)3.29684773
72behavioral defense response (GO:0002209)3.29161525
73behavioral fear response (GO:0001662)3.29161525
74layer formation in cerebral cortex (GO:0021819)3.28508899
75auditory behavior (GO:0031223)3.27611346
76positive regulation of synapse assembly (GO:0051965)3.26933281
77mechanosensory behavior (GO:0007638)3.26821826
78regulation of dendritic spine morphogenesis (GO:0061001)3.24674284
79positive regulation of synaptic transmission (GO:0050806)3.24542434
80transmission of nerve impulse (GO:0019226)3.24208149
81negative regulation of dendrite morphogenesis (GO:0050774)3.24074341
82membrane hyperpolarization (GO:0060081)3.23893820
83regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.23594797
84synaptic transmission (GO:0007268)3.22869001
85cellular potassium ion homeostasis (GO:0030007)3.21185575
86learning (GO:0007612)3.18993426
87opioid receptor signaling pathway (GO:0038003)3.18723486
88dendritic spine morphogenesis (GO:0060997)3.17555112
89membrane depolarization during action potential (GO:0086010)3.15393396
90regulation of synaptic transmission (GO:0050804)3.12514957
91regulation of voltage-gated calcium channel activity (GO:1901385)3.12387379
92synapse assembly (GO:0007416)3.11398214
93negative regulation of amino acid transport (GO:0051956)3.10906855
94activation of protein kinase A activity (GO:0034199)3.10550081
95regulation of respiratory system process (GO:0044065)3.08313668
96limb bud formation (GO:0060174)3.06958951
97detection of calcium ion (GO:0005513)3.04645779
98regulation of dendritic spine development (GO:0060998)3.02038206
99neuromuscular process controlling posture (GO:0050884)2.99980044
100response to auditory stimulus (GO:0010996)2.97645292
101social behavior (GO:0035176)2.96717198
102intraspecies interaction between organisms (GO:0051703)2.96717198
103neuron fate determination (GO:0048664)2.92823633
104energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.91728944
105ATP hydrolysis coupled proton transport (GO:0015991)2.91728944
106sequestering of actin monomers (GO:0042989)2.86893990
107hindbrain development (GO:0030902)2.86675489
108nonmotile primary cilium assembly (GO:0035058)2.84450644
109positive regulation of dendritic spine morphogenesis (GO:0061003)2.83993556
110negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81811288
111negative regulation of translation, ncRNA-mediated (GO:0040033)2.81811288
112regulation of translation, ncRNA-mediated (GO:0045974)2.81811288
113neuron projection extension involved in neuron projection guidance (GO:1902284)2.81125178
114axon extension involved in axon guidance (GO:0048846)2.81125178
115nucleobase catabolic process (GO:0046113)2.80517101
116establishment of protein localization to mitochondrial membrane (GO:0090151)2.78739837
117negative regulation of axon guidance (GO:1902668)2.75766013
118retinal ganglion cell axon guidance (GO:0031290)2.75616473
119thalamus development (GO:0021794)2.74528319
120negative chemotaxis (GO:0050919)2.71273538
121central nervous system projection neuron axonogenesis (GO:0021952)2.61339752
122chaperone-mediated protein transport (GO:0072321)2.61266907
123innervation (GO:0060384)2.61116371
124retinal cone cell development (GO:0046549)2.60458781
125epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60434826
126lateral sprouting from an epithelium (GO:0060601)2.59380247
127neuromuscular synaptic transmission (GO:0007274)2.57204870
128mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.55777937
129inner ear receptor stereocilium organization (GO:0060122)2.54924874
130midbrain development (GO:0030901)2.51709855
131short-term memory (GO:0007614)2.48955452
132negative regulation of axon extension (GO:0030517)2.48171524
133cell migration in hindbrain (GO:0021535)2.44915041
134protein neddylation (GO:0045116)2.44407411
135detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.42560917
136cerebral cortex radially oriented cell migration (GO:0021799)2.41010478
137cochlea development (GO:0090102)2.39784694
138ganglion development (GO:0061548)2.38008593
139regulation of synapse assembly (GO:0051963)2.37515269
140C4-dicarboxylate transport (GO:0015740)2.35646674
141neuronal stem cell maintenance (GO:0097150)2.32170521
142mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.30415677
143ATP synthesis coupled proton transport (GO:0015986)2.30413510
144energy coupled proton transport, down electrochemical gradient (GO:0015985)2.30413510
145serotonin metabolic process (GO:0042428)2.30021539
146negative regulation of axonogenesis (GO:0050771)2.29920994
147retina layer formation (GO:0010842)2.29543648
148neurofilament cytoskeleton organization (GO:0060052)2.26770362
149chromatin remodeling at centromere (GO:0031055)2.26410317
150protein localization to cilium (GO:0061512)2.25840807
151atrial cardiac muscle cell action potential (GO:0086014)2.25116022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.31839000
2GBX2_23144817_ChIP-Seq_PC3_Human4.35907220
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.14011415
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12505537
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03127796
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96745563
7REST_21632747_ChIP-Seq_MESCs_Mouse2.65509330
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63638998
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54411017
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54411017
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46987249
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46297992
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.45851757
14TAF15_26573619_Chip-Seq_HEK293_Human2.45160042
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36673656
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33548869
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31740932
18* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30669853
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.30325568
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29789254
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23370789
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.17292580
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.11683956
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.11341431
25* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10227752
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09736050
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05009822
28DROSHA_22980978_ChIP-Seq_HELA_Human2.04067510
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00460321
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.99265833
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.95403102
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91564653
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90524930
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.88500491
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82761854
36AR_21572438_ChIP-Seq_LNCaP_Human1.82433951
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81314761
38* P300_19829295_ChIP-Seq_ESCs_Human1.78557536
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76798851
40FUS_26573619_Chip-Seq_HEK293_Human1.75070302
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70986655
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67625513
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62882293
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61606128
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60498797
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59803486
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59751444
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.58279419
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.56339860
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.51298825
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49664687
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.46632337
53AR_25329375_ChIP-Seq_VCAP_Human1.45817496
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43403731
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43136094
56* SOX2_21211035_ChIP-Seq_LN229_Gbm1.40261250
57RNF2_27304074_Chip-Seq_NSC_Mouse1.39737437
58* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37863125
59* STAT3_23295773_ChIP-Seq_U87_Human1.37140670
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36239320
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36067695
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31234142
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30488441
64IRF1_19129219_ChIP-ChIP_H3396_Human1.30430291
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.29101581
66VDR_22108803_ChIP-Seq_LS180_Human1.28768479
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28592621
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27904192
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26959205
70* TCF4_23295773_ChIP-Seq_U87_Human1.24327020
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24265947
72* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22400490
73ZNF274_21170338_ChIP-Seq_K562_Hela1.22108920
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22054713
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.22014216
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21415873
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.18887037
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18789808
79ER_23166858_ChIP-Seq_MCF-7_Human1.16912726
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16800070
81* AR_19668381_ChIP-Seq_PC3_Human1.15075646
82* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14777011
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.12881402
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.12534791
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12455049
86RUNX2_22187159_ChIP-Seq_PCA_Human1.11902747
87IGF1R_20145208_ChIP-Seq_DFB_Human1.11424704
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11346035
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11108196
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.10434513
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10404780
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10260233
93JUN_21703547_ChIP-Seq_K562_Human1.09992089
94SOX9_26525672_Chip-Seq_HEART_Mouse1.09667905
95* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09595462
96TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09012959
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08131480
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07926492
99TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07680577
100AHR_22903824_ChIP-Seq_MCF-7_Human1.07006939
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.06742885
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06615168
103BCAT_22108803_ChIP-Seq_LS180_Human1.05183025
104* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04792329
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02511446
106EST1_17652178_ChIP-ChIP_JURKAT_Human1.01982299
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01943470
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01126398
109TP63_19390658_ChIP-ChIP_HaCaT_Human1.00834510
110EWS_26573619_Chip-Seq_HEK293_Human1.00587989
111* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99996839
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99147008
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99147008
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98332247
115CBP_20019798_ChIP-Seq_JUKART_Human0.98332247
116* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98320504
117E2F1_18555785_Chip-Seq_ESCs_Mouse0.97005063
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96934647
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96813786
120TP53_16413492_ChIP-PET_HCT116_Human0.95191284
121CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94438029
122FLI1_27457419_Chip-Seq_LIVER_Mouse0.94368095
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94314538
124* KDM2B_26808549_Chip-Seq_REH_Human0.93727619
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93723182
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93559908
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93549511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.84165865
2MP0004859_abnormal_synaptic_plasticity5.72233846
3MP0003635_abnormal_synaptic_transmissio4.07388092
4MP0009745_abnormal_behavioral_response3.67101612
5MP0001968_abnormal_touch/_nociception3.61080085
6MP0004270_analgesia3.37044512
7MP0002064_seizures3.35209608
8MP0009046_muscle_twitch3.34209196
9MP0002063_abnormal_learning/memory/cond3.27967265
10MP0002572_abnormal_emotion/affect_behav2.96421553
11MP0002736_abnormal_nociception_after2.90708910
12MP0002734_abnormal_mechanical_nocicepti2.71088151
13MP0002272_abnormal_nervous_system2.70469766
14MP0001501_abnormal_sleep_pattern2.68766603
15MP0002735_abnormal_chemical_nociception2.63515719
16MP0003136_yellow_coat_color2.54396841
17MP0001486_abnormal_startle_reflex2.52682045
18MP0002822_catalepsy2.41628886
19MP0005423_abnormal_somatic_nervous2.38890517
20MP0002067_abnormal_sensory_capabilities2.21504438
21MP0001440_abnormal_grooming_behavior2.21489151
22MP0003890_abnormal_embryonic-extraembry2.20400848
23MP0006276_abnormal_autonomic_nervous2.11622546
24MP0003787_abnormal_imprinting2.11445146
25MP0002733_abnormal_thermal_nociception2.09512009
26MP0003283_abnormal_digestive_organ2.07702509
27MP0001970_abnormal_pain_threshold2.03985233
28MP0003879_abnormal_hair_cell1.98471848
29MP0004133_heterotaxia1.95348834
30MP0005646_abnormal_pituitary_gland1.83164241
31MP0002184_abnormal_innervation1.78790540
32MP0002557_abnormal_social/conspecific_i1.73412748
33MP0004924_abnormal_behavior1.72202178
34MP0005386_behavior/neurological_phenoty1.72202178
35MP0001293_anophthalmia1.67141275
36MP0000778_abnormal_nervous_system1.65260742
37MP0001529_abnormal_vocalization1.61362181
38MP0008569_lethality_at_weaning1.60922033
39MP0009780_abnormal_chondrocyte_physiolo1.60502032
40MP0001984_abnormal_olfaction1.55893472
41MP0009379_abnormal_foot_pigmentation1.52259642
42MP0001502_abnormal_circadian_rhythm1.51508291
43MP0004811_abnormal_neuron_physiology1.50953294
44MP0001188_hyperpigmentation1.49799620
45MP0003011_delayed_dark_adaptation1.49434702
46MP0001905_abnormal_dopamine_level1.48012349
47MP0002751_abnormal_autonomic_nervous1.47425244
48MP0003329_amyloid_beta_deposits1.47243823
49MP0010386_abnormal_urinary_bladder1.45771540
50MP0003122_maternal_imprinting1.44506290
51MP0003119_abnormal_digestive_system1.39276443
52MP0004858_abnormal_nervous_system1.38970903
53MP0002066_abnormal_motor_capabilities/c1.37194808
54MP0004142_abnormal_muscle_tone1.34914874
55MP0000955_abnormal_spinal_cord1.33809943
56MP0002882_abnormal_neuron_morphology1.32213833
57MP0003937_abnormal_limbs/digits/tail_de1.29236734
58MP0000566_synostosis1.27502049
59MP0003633_abnormal_nervous_system1.19748301
60MP0002938_white_spotting1.19310054
61MP0010030_abnormal_orbit_morphology1.16678362
62MP0003938_abnormal_ear_development1.15003484
63MP0002909_abnormal_adrenal_gland1.13868489
64MP0008877_abnormal_DNA_methylation1.13724385
65MP0000049_abnormal_middle_ear1.13432403
66MP0008789_abnormal_olfactory_epithelium1.10644597
67MP0008872_abnormal_physiological_respon1.08897183
68MP0005645_abnormal_hypothalamus_physiol1.08703970
69MP0004742_abnormal_vestibular_system1.07653405
70MP0005551_abnormal_eye_electrophysiolog1.06965866
71MP0003631_nervous_system_phenotype1.06407610
72MP0002234_abnormal_pharynx_morphology1.06282443
73MP0001286_abnormal_eye_development1.04965409
74MP0003123_paternal_imprinting1.03833758
75MP0001963_abnormal_hearing_physiology1.01339742
76MP0002152_abnormal_brain_morphology1.01228431
77MP0000751_myopathy1.00899211
78MP0003941_abnormal_skin_development0.99147081
79MP0002876_abnormal_thyroid_physiology0.96948990
80MP0002638_abnormal_pupillary_reflex0.95985729
81MP0008874_decreased_physiological_sensi0.95155656
82MP0002697_abnormal_eye_size0.95043133
83MP0004885_abnormal_endolymph0.94859988
84MP0002229_neurodegeneration0.94317613
85MP0004145_abnormal_muscle_electrophysio0.93729282
86MP0002837_dystrophic_cardiac_calcinosis0.93671676
87MP0002653_abnormal_ependyma_morphology0.91249277
88MP0005248_abnormal_Harderian_gland0.91080844
89MP0002233_abnormal_nose_morphology0.90717061
90MP0002282_abnormal_trachea_morphology0.90620873
91MP0005187_abnormal_penis_morphology0.90037061
92MP0005195_abnormal_posterior_eye0.87389507
93MP0005391_vision/eye_phenotype0.85369128
94MP0001485_abnormal_pinna_reflex0.84999889
95MP0002069_abnormal_eating/drinking_beha0.84435677
96MP0004085_abnormal_heartbeat0.81208545
97MP0002752_abnormal_somatic_nervous0.80944108
98MP0001346_abnormal_lacrimal_gland0.80556835
99MP0003121_genomic_imprinting0.80308999
100MP0004484_altered_response_of0.79613917
101MP0001177_atelectasis0.77672102
102MP0004215_abnormal_myocardial_fiber0.76993643
103MP0008058_abnormal_DNA_repair0.75346451
104MP0003137_abnormal_impulse_conducting0.72817814
105MP0003632_abnormal_nervous_system0.72650396
106MP0002102_abnormal_ear_morphology0.72422716
107MP0001986_abnormal_taste_sensitivity0.70160981
108MP0003942_abnormal_urinary_system0.70076952
109MP0005535_abnormal_body_temperature0.69735719
110MP0003567_abnormal_fetal_cardiomyocyte0.69626999
111MP0005084_abnormal_gallbladder_morpholo0.69010544
112MP0000013_abnormal_adipose_tissue0.68246181
113MP0004147_increased_porphyrin_level0.68182967
114MP0000631_abnormal_neuroendocrine_gland0.67773649
115MP0005394_taste/olfaction_phenotype0.66672480
116MP0005499_abnormal_olfactory_system0.66672480
117MP0000026_abnormal_inner_ear0.65977972
118MP0003646_muscle_fatigue0.65651859
119MP0001664_abnormal_digestion0.64355603
120MP0005171_absent_coat_pigmentation0.62156935
121MP0000569_abnormal_digit_pigmentation0.61792731
122MP0004233_abnormal_muscle_weight0.60337734
123MP0003634_abnormal_glial_cell0.56197085
124MP0001943_abnormal_respiration0.56105294
125MP0006292_abnormal_olfactory_placode0.55105494
126MP0006072_abnormal_retinal_apoptosis0.54455877
127MP0000604_amyloidosis0.53530041
128MP0010770_preweaning_lethality0.51842777
129MP0002082_postnatal_lethality0.51842777
130MP0005253_abnormal_eye_physiology0.50920978
131MP0010769_abnormal_survival0.50203799
132MP0003861_abnormal_nervous_system0.48671262
133MP0004043_abnormal_pH_regulation0.48200928

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.78405571
2Atonic seizures (HP:0010819)6.29054056
3Focal seizures (HP:0007359)6.21994451
4Epileptic encephalopathy (HP:0200134)6.02303314
5Febrile seizures (HP:0002373)5.75336523
6Myokymia (HP:0002411)5.67564823
7Absence seizures (HP:0002121)5.05129222
8Hyperventilation (HP:0002883)5.01340667
9Visual hallucinations (HP:0002367)4.76156369
10Dialeptic seizures (HP:0011146)4.69541009
11Generalized tonic-clonic seizures (HP:0002069)4.32535952
12Broad-based gait (HP:0002136)4.20174611
13Progressive cerebellar ataxia (HP:0002073)4.15898388
14Gaze-evoked nystagmus (HP:0000640)3.56421194
15Amblyopia (HP:0000646)3.43301928
16Septo-optic dysplasia (HP:0100842)3.41052662
17Impaired vibration sensation in the lower limbs (HP:0002166)3.17564872
18Protruding tongue (HP:0010808)3.12788505
19Poor eye contact (HP:0000817)3.11932682
20Drooling (HP:0002307)3.08475474
21Excessive salivation (HP:0003781)3.08475474
22Truncal ataxia (HP:0002078)3.04405357
23Colon cancer (HP:0003003)2.94853277
24Dysdiadochokinesis (HP:0002075)2.94601212
25True hermaphroditism (HP:0010459)2.93742512
26Abnormal eating behavior (HP:0100738)2.91255742
27Action tremor (HP:0002345)2.87873517
28Impaired social interactions (HP:0000735)2.83576167
29Abnormal social behavior (HP:0012433)2.83576167
30Pancreatic fibrosis (HP:0100732)2.78334890
31Urinary bladder sphincter dysfunction (HP:0002839)2.74880954
32Nephronophthisis (HP:0000090)2.72677543
33Abnormality of midbrain morphology (HP:0002418)2.68612870
34Molar tooth sign on MRI (HP:0002419)2.68612870
35Absent speech (HP:0001344)2.68505104
36Depression (HP:0000716)2.67267796
37Epileptiform EEG discharges (HP:0011182)2.67043968
38Progressive inability to walk (HP:0002505)2.63877949
39Dysmetria (HP:0001310)2.63764321
40Optic nerve hypoplasia (HP:0000609)2.57762781
41Pancreatic cysts (HP:0001737)2.56955687
42Anxiety (HP:0000739)2.55956113
43Supranuclear gaze palsy (HP:0000605)2.55350518
44Inability to walk (HP:0002540)2.53609940
45Ankle clonus (HP:0011448)2.53230946
46Insidious onset (HP:0003587)2.52102773
47Termporal pattern (HP:0011008)2.52102773
48Abnormal hair whorl (HP:0010721)2.49757654
49Fetal akinesia sequence (HP:0001989)2.49252011
50Polyphagia (HP:0002591)2.44935469
51Postural instability (HP:0002172)2.44069537
52Impaired smooth pursuit (HP:0007772)2.41842970
53Blue irides (HP:0000635)2.36261159
54Status epilepticus (HP:0002133)2.35575270
55EEG with generalized epileptiform discharges (HP:0011198)2.34597357
56Chronic hepatic failure (HP:0100626)2.33642562
57Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.33485177
58Hemiparesis (HP:0001269)2.33269646
59Vaginal atresia (HP:0000148)2.33241516
60Hepatoblastoma (HP:0002884)2.32742991
61Dysmetric saccades (HP:0000641)2.31824994
62Bilateral microphthalmos (HP:0007633)2.30316774
63Supernumerary spleens (HP:0009799)2.28568422
64Thyroid-stimulating hormone excess (HP:0002925)2.28229996
65Labial hypoplasia (HP:0000066)2.27742656
66Gait imbalance (HP:0002141)2.27534843
67Impaired vibratory sensation (HP:0002495)2.23731362
68Urinary urgency (HP:0000012)2.23542341
69Abnormality of the corticospinal tract (HP:0002492)2.23183686
70Scanning speech (HP:0002168)2.23179673
71Abnormality of the lower motor neuron (HP:0002366)2.20000968
72Hyperglycinemia (HP:0002154)2.19837834
73Hypoplastic female external genitalia (HP:0012815)2.19380275
74Anophthalmia (HP:0000528)2.18930778
75Genetic anticipation (HP:0003743)2.18902574
76Spastic gait (HP:0002064)2.18371656
77Absent septum pellucidum (HP:0001331)2.17457614
78Stereotypic behavior (HP:0000733)2.14410577
79Bradykinesia (HP:0002067)2.12560124
80Abnormality of the renal medulla (HP:0100957)2.11121317
81Abnormality of salivation (HP:0100755)2.10867678
82Hypsarrhythmia (HP:0002521)2.10843477
83Pheochromocytoma (HP:0002666)2.10532057
84Fair hair (HP:0002286)2.10476939
85Abnormal lung lobation (HP:0002101)2.09255245
86Abnormality of the labia minora (HP:0012880)2.09186063
87Abnormality of binocular vision (HP:0011514)2.08573020
88Diplopia (HP:0000651)2.08573020
89Intestinal atresia (HP:0011100)2.08131898
90Generalized myoclonic seizures (HP:0002123)2.07290589
91Abnormality of ocular smooth pursuit (HP:0000617)2.06953063
92Birth length less than 3rd percentile (HP:0003561)2.06779202
93Aplasia/Hypoplasia of the tibia (HP:0005772)2.06521493
94Specific learning disability (HP:0001328)2.05659899
95Congenital primary aphakia (HP:0007707)2.05037794
96Breast aplasia (HP:0100783)2.03666331
97Exotropia (HP:0000577)2.01901271
98Generalized hypopigmentation of hair (HP:0011358)2.00781871
99Hemiplegia (HP:0002301)2.00732082
100Failure to thrive in infancy (HP:0001531)2.00019711
101Degeneration of the lateral corticospinal tracts (HP:0002314)1.99643213
102Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.99643213
103Increased hepatocellular lipid droplets (HP:0006565)1.98856994
104Medial flaring of the eyebrow (HP:0010747)1.97952427
105Hypoventilation (HP:0002791)1.97513529
106Delusions (HP:0000746)1.97177194
107Mutism (HP:0002300)1.96928889
108Bifid tongue (HP:0010297)1.96298849
109Neuroendocrine neoplasm (HP:0100634)1.94270161
110Incomplete penetrance (HP:0003829)1.93023614
111Gait ataxia (HP:0002066)1.91912745
112Hyperthyroidism (HP:0000836)1.91127560
113Torticollis (HP:0000473)1.91048357
114Cerebral inclusion bodies (HP:0100314)1.89539607
115Short tibia (HP:0005736)1.89480471
116Narrow nasal bridge (HP:0000446)1.88999183
117Anencephaly (HP:0002323)1.88858023
118Nephrogenic diabetes insipidus (HP:0009806)1.88060260
119Limb dystonia (HP:0002451)1.87608833
120Abnormality of the septum pellucidum (HP:0007375)1.87340130
121Aplasia/Hypoplasia of the breasts (HP:0010311)1.87231745
122Lower limb muscle weakness (HP:0007340)1.85485485
123Focal dystonia (HP:0004373)1.85257958
124Esophageal atresia (HP:0002032)1.84050555
125Volvulus (HP:0002580)1.83150172
126Oligodactyly (hands) (HP:0001180)1.82700334
127Bile duct proliferation (HP:0001408)1.82401366
128Abnormal biliary tract physiology (HP:0012439)1.82401366
129Psychosis (HP:0000709)1.81969881
130Stenosis of the external auditory canal (HP:0000402)1.81546613
131Poor coordination (HP:0002370)1.81479680
132Esotropia (HP:0000565)1.80884163
133Thickened helices (HP:0000391)1.80849048
134Postaxial hand polydactyly (HP:0001162)1.80686906
135Gastrointestinal atresia (HP:0002589)1.80265486
136Hypothermia (HP:0002045)1.79478789
137Retinal dysplasia (HP:0007973)1.79193011
138Maternal diabetes (HP:0009800)1.78027297
139Inappropriate behavior (HP:0000719)1.77094845
140Genital tract atresia (HP:0001827)1.76247356
141Growth hormone deficiency (HP:0000824)1.73842454
142Abolished electroretinogram (ERG) (HP:0000550)1.73711497
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.73485753
144Megalencephaly (HP:0001355)1.72881387
145Aplasia/Hypoplasia of the sternum (HP:0006714)1.72238071
146Vitreoretinal degeneration (HP:0000655)1.71292105
147Type II lissencephaly (HP:0007260)1.70931921
148Absent/shortened dynein arms (HP:0200106)1.70915056
149Dynein arm defect of respiratory motile cilia (HP:0012255)1.70915056
150Hypoplastic labia majora (HP:0000059)1.70478572
151Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69971835
152Sleep apnea (HP:0010535)1.69885661
153Chorioretinal coloboma (HP:0000567)1.69135761
154Acute necrotizing encephalopathy (HP:0006965)1.68594015
155Sclerocornea (HP:0000647)1.67206112
156Mitochondrial inheritance (HP:0001427)1.66382169
157Scrotal hypoplasia (HP:0000046)1.65660906
158Preaxial hand polydactyly (HP:0001177)1.65624421
159Abnormal ciliary motility (HP:0012262)1.63308203
160Congenital, generalized hypertrichosis (HP:0004540)1.63211715
161Lipid accumulation in hepatocytes (HP:0006561)1.63203572
162Rib fusion (HP:0000902)1.62652996
163Chorioretinal atrophy (HP:0000533)1.61735047
164Lissencephaly (HP:0001339)1.61497263
165Acute encephalopathy (HP:0006846)1.60606484
166Dandy-Walker malformation (HP:0001305)1.60241180
167Pendular nystagmus (HP:0012043)1.60051671
168Micropenis (HP:0000054)1.59497928
169Cystic liver disease (HP:0006706)1.58184776
170Abnormality of the labia (HP:0000058)1.57834646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.87828456
2NTRK34.60149465
3EPHA44.08949248
4ADRBK23.48598946
5MAP3K43.43704596
6MAP3K93.24323638
7MAP2K73.18036345
8MAP3K122.92586097
9DAPK22.48121195
10MKNK22.37093301
11TNIK2.15815842
12MKNK12.15402667
13MAP2K42.12939136
14CDK192.11515216
15MINK12.10592307
16DYRK21.98458654
17PLK21.94880569
18NTRK21.86240980
19DAPK11.81771219
20PAK61.80985521
21MARK11.80123899
22RIPK41.78823104
23NTRK11.77319438
24BRD41.74588172
25TAF11.70175218
26MAPK131.65484595
27MAP3K101.62653669
28BMPR1B1.59612677
29KSR21.57334105
30GRK51.52992557
31AKT31.51910350
32PNCK1.47289177
33KSR11.40734099
34CAMKK21.37759808
35ARAF1.35585784
36PRPF4B1.32094246
37CCNB11.31357704
38CAMKK11.27710843
39CDK51.26436516
40TRIM281.26056115
41NEK11.25126002
42OXSR11.24024209
43PLK31.21269565
44CDC71.18571343
45VRK21.15430038
46PRKCG1.11902695
47ZAK1.09788424
48CAMK2A1.09200442
49FES1.09029945
50DYRK31.08456815
51PRKD31.01984144
52WEE11.01399841
53SIK20.99141107
54INSRR0.97975691
55MAP3K130.97743979
56SRPK10.96735108
57SGK20.96681711
58NUAK10.96431202
59VRK10.96288591
60STK380.95654369
61SGK2230.95610383
62SGK4940.95610383
63BMPR20.94886659
64BUB10.91383052
65PTK2B0.89141243
66CAMK2B0.88305094
67SIK30.88211928
68MAP3K60.86952579
69STK38L0.85332194
70BRAF0.83451951
71UHMK10.82663757
72PASK0.82644350
73CDK180.81754698
74EPHB20.81686260
75CSNK1G10.80018975
76TGFBR10.78772104
77LATS20.78441413
78CDK150.76349230
79FRK0.75759814
80NME10.75597228
81FGR0.74694540
82CDK140.74344627
83TNK20.72704553
84CAMK10.71088034
85GRK10.70462723
86FGFR20.70239874
87STK110.69207159
88MUSK0.67312543
89TYRO30.66593269
90STK160.66224901
91TTK0.65694761
92GRK70.65638449
93PRKCE0.65386718
94BRSK20.64619217
95CDK11A0.64523801
96SGK10.64206398
97RAF10.63885173
98SGK30.61684405
99FER0.61513571
100PBK0.60635110
101STK390.58500669
102PLK40.57420415
103EIF2AK30.57260952
104CSNK1G20.56656364
105PLK10.56295258
106CSNK1A1L0.56181390
107MAP3K20.56023288
108TSSK60.55090749
109CDK30.54962240
110CSNK1G30.53817404
111BCR0.53729145
112ACVR1B0.53384161
113RET0.53134037
114NEK20.53133807
115DYRK1A0.52138469
116CSNK1E0.52136615
117CAMK2D0.47524783
118PAK30.45668774
119TAOK10.45213028
120ADRBK10.44930972
121CAMK40.44764014
122WNK40.43399808
123ERBB20.43183551
124CAMK1G0.43120663
125ALK0.43019664
126PKN10.42295766
127PRKCH0.41744198
128PINK10.41670940
129CAMK2G0.41359113
130NLK0.39678552
131MAP3K10.39466565
132WNK30.39404978
133PDK10.39015307
134BRSK10.38332494
135DAPK30.38293317
136MAP2K10.37886110
137PRKG10.37485369
138RPS6KA30.36196928
139NEK60.34476964
140PDPK10.34217673
141CHEK20.34147834
142DYRK1B0.34039510
143MARK20.32976542
144MAPK120.32249923
145MAPK100.32152482
146PHKG20.31471602
147PHKG10.31471602
148CDC42BPA0.30879037
149ROCK20.30682345
150PRKACA0.29490920
151PRKCZ0.29372923

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.52199711
2Synaptic vesicle cycle_Homo sapiens_hsa047213.85235120
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.00878122
4GABAergic synapse_Homo sapiens_hsa047272.85913665
5Long-term potentiation_Homo sapiens_hsa047202.79406048
6Circadian entrainment_Homo sapiens_hsa047132.67448357
7Morphine addiction_Homo sapiens_hsa050322.64061769
8Glutamatergic synapse_Homo sapiens_hsa047242.63395742
9Amphetamine addiction_Homo sapiens_hsa050312.60421352
10Olfactory transduction_Homo sapiens_hsa047402.55346506
11Collecting duct acid secretion_Homo sapiens_hsa049662.48718994
12Dopaminergic synapse_Homo sapiens_hsa047282.18211107
13Taste transduction_Homo sapiens_hsa047422.14748307
14Ribosome_Homo sapiens_hsa030102.10521790
15Salivary secretion_Homo sapiens_hsa049702.10134245
16Protein export_Homo sapiens_hsa030602.08649740
17Insulin secretion_Homo sapiens_hsa049111.99519663
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87771758
19Serotonergic synapse_Homo sapiens_hsa047261.87666749
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85374600
21Cholinergic synapse_Homo sapiens_hsa047251.77592305
22Long-term depression_Homo sapiens_hsa047301.71756999
23Gastric acid secretion_Homo sapiens_hsa049711.71308386
24Renin secretion_Homo sapiens_hsa049241.69484676
25Basal cell carcinoma_Homo sapiens_hsa052171.65292474
26Calcium signaling pathway_Homo sapiens_hsa040201.62358252
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62240664
28Oxytocin signaling pathway_Homo sapiens_hsa049211.61687810
29RNA polymerase_Homo sapiens_hsa030201.61371078
30Hedgehog signaling pathway_Homo sapiens_hsa043401.56570020
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49570693
32Cocaine addiction_Homo sapiens_hsa050301.49414613
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46227506
34Vibrio cholerae infection_Homo sapiens_hsa051101.43255834
35GnRH signaling pathway_Homo sapiens_hsa049121.37491274
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37489809
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34051467
38Basal transcription factors_Homo sapiens_hsa030221.33092424
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32220613
40Steroid biosynthesis_Homo sapiens_hsa001001.29218236
41Phototransduction_Homo sapiens_hsa047441.28814327
42Butanoate metabolism_Homo sapiens_hsa006501.28649910
43Propanoate metabolism_Homo sapiens_hsa006401.23922555
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22273076
45cAMP signaling pathway_Homo sapiens_hsa040241.21458682
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20764977
47Selenocompound metabolism_Homo sapiens_hsa004501.15265603
48Gap junction_Homo sapiens_hsa045401.13552035
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.10323433
50RNA degradation_Homo sapiens_hsa030181.07179537
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07155007
52Cardiac muscle contraction_Homo sapiens_hsa042601.06984734
53Estrogen signaling pathway_Homo sapiens_hsa049151.06896505
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05694369
55Oxidative phosphorylation_Homo sapiens_hsa001901.04551424
56Axon guidance_Homo sapiens_hsa043601.04155799
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03842044
58Hippo signaling pathway_Homo sapiens_hsa043901.02525866
59ErbB signaling pathway_Homo sapiens_hsa040121.00608600
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00566826
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96818325
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96269031
63Type II diabetes mellitus_Homo sapiens_hsa049300.94348346
64Melanogenesis_Homo sapiens_hsa049160.93538233
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91898455
66Glioma_Homo sapiens_hsa052140.91780439
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.91208406
68Oocyte meiosis_Homo sapiens_hsa041140.90319191
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90055463
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.88086489
71Nitrogen metabolism_Homo sapiens_hsa009100.87381886
72Proteasome_Homo sapiens_hsa030500.85108258
73Circadian rhythm_Homo sapiens_hsa047100.81990132
74Fanconi anemia pathway_Homo sapiens_hsa034600.81429688
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80997045
76Type I diabetes mellitus_Homo sapiens_hsa049400.80818018
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80245186
78Alzheimers disease_Homo sapiens_hsa050100.80148444
79Mismatch repair_Homo sapiens_hsa034300.77015560
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73618867
81Purine metabolism_Homo sapiens_hsa002300.73292527
82Pancreatic secretion_Homo sapiens_hsa049720.72020481
83MAPK signaling pathway_Homo sapiens_hsa040100.69817857
84Dorso-ventral axis formation_Homo sapiens_hsa043200.69009915
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67375842
86Spliceosome_Homo sapiens_hsa030400.66675840
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66369634
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.65867189
89Homologous recombination_Homo sapiens_hsa034400.65455127
90RNA transport_Homo sapiens_hsa030130.65243446
91Dilated cardiomyopathy_Homo sapiens_hsa054140.64547609
92Rheumatoid arthritis_Homo sapiens_hsa053230.63254140
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62803136
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.62243213
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62109145
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61837383
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60640732
98Cell cycle_Homo sapiens_hsa041100.60565541
99Thyroid hormone synthesis_Homo sapiens_hsa049180.60327022
100Folate biosynthesis_Homo sapiens_hsa007900.59038215
101Ether lipid metabolism_Homo sapiens_hsa005650.58770799
102Linoleic acid metabolism_Homo sapiens_hsa005910.58508370
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58195542
104Tryptophan metabolism_Homo sapiens_hsa003800.58085175
105Choline metabolism in cancer_Homo sapiens_hsa052310.57003488
106Non-homologous end-joining_Homo sapiens_hsa034500.56928591
107Ras signaling pathway_Homo sapiens_hsa040140.54884889
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54012038
109Parkinsons disease_Homo sapiens_hsa050120.53347912
110Glucagon signaling pathway_Homo sapiens_hsa049220.50615551
111Inositol phosphate metabolism_Homo sapiens_hsa005620.50432772
112Huntingtons disease_Homo sapiens_hsa050160.48431208
113Regulation of autophagy_Homo sapiens_hsa041400.48243666
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45680912
115One carbon pool by folate_Homo sapiens_hsa006700.44062521
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43696018
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43540389
118African trypanosomiasis_Homo sapiens_hsa051430.43421198
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43324000
120Pyruvate metabolism_Homo sapiens_hsa006200.43293172
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43256299
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42310200
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42027738
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41824848
125VEGF signaling pathway_Homo sapiens_hsa043700.40995571
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.40819146
127Rap1 signaling pathway_Homo sapiens_hsa040150.40795292
128Biosynthesis of amino acids_Homo sapiens_hsa012300.40518230
129Alcoholism_Homo sapiens_hsa050340.39953345
130Metabolic pathways_Homo sapiens_hsa011000.39819719
131Wnt signaling pathway_Homo sapiens_hsa043100.39194277
132Peroxisome_Homo sapiens_hsa041460.38248682
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37729591
134Ovarian steroidogenesis_Homo sapiens_hsa049130.37638888
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.33829799
136Phagosome_Homo sapiens_hsa041450.29799555
137Prion diseases_Homo sapiens_hsa050200.28389780
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28078074
139Bile secretion_Homo sapiens_hsa049760.25604187
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25107739
141Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24794244
142Insulin signaling pathway_Homo sapiens_hsa049100.23237953
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20890081
144Renal cell carcinoma_Homo sapiens_hsa052110.20774069
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.20409363
146mTOR signaling pathway_Homo sapiens_hsa041500.18512244
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17801073
148Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17654370
149Chemokine signaling pathway_Homo sapiens_hsa040620.17258463
150Melanoma_Homo sapiens_hsa052180.15968292

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