ZMAT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.40729330
2proteasome assembly (GO:0043248)5.65640183
3protein complex biogenesis (GO:0070271)5.48905110
4mitochondrial respiratory chain complex assembly (GO:0033108)5.08301796
5tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.84041040
6RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.84041040
7termination of RNA polymerase III transcription (GO:0006386)4.78900227
8transcription elongation from RNA polymerase III promoter (GO:0006385)4.78900227
9ribosomal small subunit assembly (GO:0000028)4.58764499
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.50015622
11rRNA modification (GO:0000154)4.38842441
12platelet dense granule organization (GO:0060155)4.30829127
13positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.22528976
14deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.22049211
15regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.19437112
167-methylguanosine mRNA capping (GO:0006370)4.18814589
17RNA capping (GO:0036260)4.11562609
187-methylguanosine RNA capping (GO:0009452)4.11562609
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.11186315
20negative regulation of ligase activity (GO:0051352)4.11186315
21anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.09917261
22cytochrome complex assembly (GO:0017004)4.09205361
23formation of translation preinitiation complex (GO:0001731)4.08730517
24respiratory chain complex IV assembly (GO:0008535)4.06942129
25telomere maintenance via semi-conservative replication (GO:0032201)4.01738950
26regulation of cellular amino acid metabolic process (GO:0006521)3.98657565
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.98361289
28maturation of SSU-rRNA (GO:0030490)3.98143049
29DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.96133390
30mannosylation (GO:0097502)3.95365539
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.93810142
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.93810142
33signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.93810142
34pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.93359975
35pseudouridine synthesis (GO:0001522)3.90311041
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.90029502
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.90029502
38L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.89844036
39ATP synthesis coupled proton transport (GO:0015986)3.85129153
40energy coupled proton transport, down electrochemical gradient (GO:0015985)3.85129153
41signal transduction involved in DNA damage checkpoint (GO:0072422)3.85073111
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.85073111
43ribosome biogenesis (GO:0042254)3.81547620
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.80016505
45purine nucleobase biosynthetic process (GO:0009113)3.78455473
46ribosomal small subunit biogenesis (GO:0042274)3.77821868
47base-excision repair, AP site formation (GO:0006285)3.77110824
48nucleobase biosynthetic process (GO:0046112)3.76026230
49DNA strand elongation involved in DNA replication (GO:0006271)3.75843338
50ribonucleoprotein complex biogenesis (GO:0022613)3.75695650
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.74466684
52transcription from RNA polymerase I promoter (GO:0006360)3.74098440
53telomere maintenance via recombination (GO:0000722)3.74026775
54electron transport chain (GO:0022900)3.73957024
55peptidyl-histidine modification (GO:0018202)3.73952064
56respiratory electron transport chain (GO:0022904)3.73912890
57ribosomal large subunit biogenesis (GO:0042273)3.72690773
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.69401779
59transcription-coupled nucleotide-excision repair (GO:0006283)3.66074273
60ubiquinone biosynthetic process (GO:0006744)3.57502618
61positive regulation of ligase activity (GO:0051351)3.56628787
62DNA strand elongation (GO:0022616)3.55886683
63termination of RNA polymerase I transcription (GO:0006363)3.55351584
64rRNA processing (GO:0006364)3.53618484
65ribosome assembly (GO:0042255)3.52911608
66antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.52455603
67transcription elongation from RNA polymerase I promoter (GO:0006362)3.50545313
68preassembly of GPI anchor in ER membrane (GO:0016254)3.49198470
69spliceosomal snRNP assembly (GO:0000387)3.48962309
70establishment of protein localization to mitochondrial membrane (GO:0090151)3.48812850
71amino acid salvage (GO:0043102)3.46984594
72L-methionine salvage (GO:0071267)3.46984594
73L-methionine biosynthetic process (GO:0071265)3.46984594
74protein-cofactor linkage (GO:0018065)3.46579386
75viral transcription (GO:0019083)3.44234754
76translation (GO:0006412)3.40948295
77rRNA metabolic process (GO:0016072)3.39746582
78GDP-mannose metabolic process (GO:0019673)3.39392113
79translational termination (GO:0006415)3.39308496
80GTP biosynthetic process (GO:0006183)3.38843867
81protein targeting to mitochondrion (GO:0006626)3.38467638
82cellular component biogenesis (GO:0044085)3.38282427
83regulation of mitochondrial translation (GO:0070129)3.36377447
84chaperone-mediated protein transport (GO:0072321)3.34678311
85tRNA processing (GO:0008033)3.34505164
86establishment of protein localization to mitochondrion (GO:0072655)3.31088025
87mitotic metaphase plate congression (GO:0007080)3.29538853
88rRNA methylation (GO:0031167)3.28009272
89DNA replication checkpoint (GO:0000076)3.27342717
90regulation of ubiquitin-protein transferase activity (GO:0051438)3.27075451
91protein deneddylation (GO:0000338)3.26790467
92exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25012480
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24729416
94metallo-sulfur cluster assembly (GO:0031163)3.24563744
95iron-sulfur cluster assembly (GO:0016226)3.24563744
96mitotic recombination (GO:0006312)3.24473238
97viral mRNA export from host cell nucleus (GO:0046784)3.21605500
98purine nucleotide salvage (GO:0032261)3.20126236
99translational initiation (GO:0006413)3.19953091
100GMP metabolic process (GO:0046037)3.19628378
101SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19604649
102maturation of 5.8S rRNA (GO:0000460)3.19310723
103protein localization to mitochondrion (GO:0070585)3.18317642
104regulation of ligase activity (GO:0051340)3.18226983
105ubiquinone metabolic process (GO:0006743)3.15998792
106cotranslational protein targeting to membrane (GO:0006613)3.14766430
107telomere maintenance via telomere lengthening (GO:0010833)3.14372002
108DNA replication initiation (GO:0006270)3.14095133
109cullin deneddylation (GO:0010388)3.13379734
110DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.12985424
111translational elongation (GO:0006414)3.12911479
112transcription initiation from RNA polymerase I promoter (GO:0006361)3.12724182
113adenosine metabolic process (GO:0046085)3.12541174
114guanosine-containing compound biosynthetic process (GO:1901070)3.12334059
115positive regulation of cell cycle arrest (GO:0071158)3.11361499
116protein targeting to ER (GO:0045047)3.10463431
117GPI anchor metabolic process (GO:0006505)3.10008190
118deoxyribonucleotide catabolic process (GO:0009264)3.09964863
119pyrimidine nucleotide catabolic process (GO:0006244)3.08825877
120tRNA modification (GO:0006400)3.07651066
121cell cycle G1/S phase transition (GO:0044843)3.07395710
122G1/S transition of mitotic cell cycle (GO:0000082)3.07395710
123protein neddylation (GO:0045116)3.06970599
124CENP-A containing nucleosome assembly (GO:0034080)3.06189624
125mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.05024088
126mitochondrial respiratory chain complex I assembly (GO:0032981)3.04523084
127NADH dehydrogenase complex assembly (GO:0010257)3.04523084
128mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04523084
129C-terminal protein lipidation (GO:0006501)3.04445190
130GPI anchor biosynthetic process (GO:0006506)3.04096208
131protein localization to endoplasmic reticulum (GO:0070972)3.03864369
132transcription elongation from RNA polymerase II promoter (GO:0006368)3.03114924
133water-soluble vitamin biosynthetic process (GO:0042364)3.02025262
134energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.93601261
135ATP hydrolysis coupled proton transport (GO:0015991)2.93601261
136deoxyribose phosphate catabolic process (GO:0046386)2.90258867
137intracellular protein transmembrane import (GO:0044743)2.90254740
138hydrogen ion transmembrane transport (GO:1902600)2.87600972
139mitochondrial RNA metabolic process (GO:0000959)2.86439996
140pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.84003418
141inner mitochondrial membrane organization (GO:0007007)2.83896982
142C-terminal protein amino acid modification (GO:0018410)2.83101332
143positive regulation of prostaglandin secretion (GO:0032308)2.78933326
144proton transport (GO:0015992)2.78585172
145behavioral response to nicotine (GO:0035095)2.76899063
146L-fucose catabolic process (GO:0042355)2.74556123
147fucose catabolic process (GO:0019317)2.74556123
148L-fucose metabolic process (GO:0042354)2.74556123
149hydrogen transport (GO:0006818)2.74295253
150UTP biosynthetic process (GO:0006228)2.74292373
151negative regulation of telomere maintenance (GO:0032205)2.73435039
152quinone biosynthetic process (GO:1901663)2.70273222
153tryptophan catabolic process (GO:0006569)2.68508189
154indole-containing compound catabolic process (GO:0042436)2.68508189
155indolalkylamine catabolic process (GO:0046218)2.68508189
156kynurenine metabolic process (GO:0070189)2.68361287
157response to pheromone (GO:0019236)2.68152026
158purine-containing compound salvage (GO:0043101)2.67782278
159autophagic vacuole fusion (GO:0000046)2.64644664
160purine nucleoside triphosphate biosynthetic process (GO:0009145)2.63223948
161purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.60701490
162adaptation of signaling pathway (GO:0023058)2.59778658

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.25496231
2JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.13195416
3E2F7_22180533_ChIP-Seq_HELA_Human3.99310327
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.95885319
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.82620677
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.79618506
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.61641125
8* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.59536741
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.59268444
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.45572371
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.27070698
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04448007
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.03668333
14ZNF274_21170338_ChIP-Seq_K562_Hela3.00336427
15* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.74145742
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.73886760
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.73373335
18* VDR_23849224_ChIP-Seq_CD4+_Human2.69988643
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69909850
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62636611
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.62474655
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.53377704
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.39724937
24XRN2_22483619_ChIP-Seq_HELA_Human2.29338795
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26549586
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.26165603
27* SRF_21415370_ChIP-Seq_HL-1_Mouse2.24119604
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23361818
29* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.18388933
30DCP1A_22483619_ChIP-Seq_HELA_Human2.15468587
31FOXP3_21729870_ChIP-Seq_TREG_Human2.10307664
32* GABP_19822575_ChIP-Seq_HepG2_Human2.07332849
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06998353
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04086447
35* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.01829762
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96889620
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90795380
38VDR_22108803_ChIP-Seq_LS180_Human1.89862540
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87606887
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86905668
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85865716
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.80082083
43TTF2_22483619_ChIP-Seq_HELA_Human1.78855593
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75065306
45ELK1_19687146_ChIP-ChIP_HELA_Human1.72423343
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70424940
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69863411
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67440270
49IRF1_19129219_ChIP-ChIP_H3396_Human1.62933170
50* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57679156
51TP53_22573176_ChIP-Seq_HFKS_Human1.56604166
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55791759
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55676099
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52572124
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.51897413
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50602848
57* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47303728
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45186377
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.44911440
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42013265
61CIITA_25753668_ChIP-Seq_RAJI_Human1.41497598
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39128357
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35343982
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34396325
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33790654
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33166397
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28030222
68PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.25240535
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24592764
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24211655
71* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22344189
72RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22191187
73KDM5A_27292631_Chip-Seq_BREAST_Human1.21285763
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21060101
75* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20154890
76BP1_19119308_ChIP-ChIP_Hs578T_Human1.17651938
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16150542
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15958867
79SPI1_23547873_ChIP-Seq_NB4_Human1.15873345
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.15733488
81IGF1R_20145208_ChIP-Seq_DFB_Human1.14359560
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11588389
83AR_20517297_ChIP-Seq_VCAP_Human1.10723804
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10082840
85IRF8_21731497_ChIP-ChIP_J774_Mouse1.09976297
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09651577
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09367246
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09306456
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07337807
90NANOG_20526341_ChIP-Seq_ESCs_Human1.06609858
91AR_21909140_ChIP-Seq_LNCAP_Human1.06006604
92FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05153020
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.05153020
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04784014
95ERA_21632823_ChIP-Seq_H3396_Human1.04215717
96NCOR_22424771_ChIP-Seq_293T_Human1.03821116
97TAF2_19829295_ChIP-Seq_ESCs_Human1.03609734
98BCL6_27268052_Chip-Seq_Bcells_Human1.02464460
99GATA3_26560356_Chip-Seq_TH2_Human1.02328404
100MYC_19829295_ChIP-Seq_ESCs_Human0.99718758
101GATA3_21878914_ChIP-Seq_MCF-7_Human0.99639454
102E2F1_21310950_ChIP-Seq_MCF-7_Human0.98679911
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98616435
104ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97826201
105SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95910676
106PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95189167
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94476053
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94091436
109ELF1_20517297_ChIP-Seq_JURKAT_Human0.93892026
110P300_27268052_Chip-Seq_Bcells_Human0.93204936
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93072691
112EWS_26573619_Chip-Seq_HEK293_Human0.92437055
113RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91236558
114KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90496101
115FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89590852
116ERG_20517297_ChIP-Seq_VCAP_Human0.89106414
117* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88184526
118MYC_18940864_ChIP-ChIP_HL60_Human0.88060161
119STAT1_20625510_ChIP-Seq_HELA_Human0.87872794
120FLI1_27457419_Chip-Seq_LIVER_Mouse0.87731157
121CTCF_20526341_ChIP-Seq_ESCs_Human0.87597526
122* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87142892
123PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86960075
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86718311
125CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86103001
126CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86011820
127NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85927993
128E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85841182
129* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85398930
130* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84346523
131TFEB_21752829_ChIP-Seq_HELA_Human0.84199361
132RAC3_21632823_ChIP-Seq_H3396_Human0.84191957
133* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84004277
134EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.82842752
135NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82547582
136STAT4_19710469_ChIP-ChIP_TH1__Mouse0.82289428
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81074893
138* YY1_22570637_ChIP-Seq_MALME-3M_Human0.80334944
139CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80143596
140DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78829081
141IRF8_22096565_ChIP-ChIP_GC-B_Human0.78018375

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.42300293
2MP0004957_abnormal_blastocyst_morpholog3.59130755
3MP0003111_abnormal_nucleus_morphology3.52543269
4MP0008057_abnormal_DNA_replication3.09974855
5MP0010094_abnormal_chromosome_stability3.06939815
6MP0003077_abnormal_cell_cycle3.04760661
7MP0008058_abnormal_DNA_repair2.95888866
8MP0003718_maternal_effect2.93779642
9MP0003786_premature_aging2.68881885
10MP0003646_muscle_fatigue2.68729805
11MP0006292_abnormal_olfactory_placode2.47241388
12MP0008007_abnormal_cellular_replicative2.39549857
13MP0002736_abnormal_nociception_after2.39383982
14MP0005671_abnormal_response_to2.35966032
15MP0003186_abnormal_redox_activity2.33405422
16MP0008932_abnormal_embryonic_tissue2.31699074
17MP0008995_early_reproductive_senescence2.29054249
18MP0005646_abnormal_pituitary_gland2.29051143
19MP0003195_calcinosis2.26813192
20MP0002396_abnormal_hematopoietic_system2.26329781
21MP0002132_abnormal_respiratory_system2.24191164
22MP0009333_abnormal_splenocyte_physiolog2.23830635
23MP0008260_abnormal_autophagy2.17666431
24MP0001986_abnormal_taste_sensitivity2.13631791
25MP0001968_abnormal_touch/_nociception2.11295229
26MP0005084_abnormal_gallbladder_morpholo2.11194685
27MP0002102_abnormal_ear_morphology2.07913832
28MP0002837_dystrophic_cardiac_calcinosis2.06842784
29MP0003763_abnormal_thymus_physiology2.06517844
30MP0001835_abnormal_antigen_presentation2.03458884
31MP0002653_abnormal_ependyma_morphology1.93931353
32MP0003806_abnormal_nucleotide_metabolis1.87795305
33MP0008872_abnormal_physiological_respon1.86797527
34MP0005551_abnormal_eye_electrophysiolog1.83919110
35MP0008875_abnormal_xenobiotic_pharmacok1.81887513
36MP0005075_abnormal_melanosome_morpholog1.78508540
37MP0003315_abnormal_perineum_morphology1.77308249
38MP0002938_white_spotting1.72930802
39MP0004142_abnormal_muscle_tone1.72124701
40MP0008877_abnormal_DNA_methylation1.69511056
41MP0002876_abnormal_thyroid_physiology1.56725308
42MP0003011_delayed_dark_adaptation1.51027568
43MP0009785_altered_susceptibility_to1.50173440
44MP0002163_abnormal_gland_morphology1.49917668
45MP0005253_abnormal_eye_physiology1.49881747
46MP0004145_abnormal_muscle_electrophysio1.45451320
47MP0006036_abnormal_mitochondrial_physio1.43612019
48MP0001545_abnormal_hematopoietic_system1.38526517
49MP0005397_hematopoietic_system_phenotyp1.38526517
50MP0001853_heart_inflammation1.38187387
51MP0001529_abnormal_vocalization1.37023355
52MP0009764_decreased_sensitivity_to1.35737061
53MP0000490_abnormal_crypts_of1.34634549
54MP0002277_abnormal_respiratory_mucosa1.34015320
55MP0002148_abnormal_hypersensitivity_rea1.31687562
56MP0000689_abnormal_spleen_morphology1.30775682
57MP0002398_abnormal_bone_marrow1.29495701
58MP0009379_abnormal_foot_pigmentation1.28652359
59MP0005645_abnormal_hypothalamus_physiol1.27914804
60MP0003123_paternal_imprinting1.27740292
61MP0002722_abnormal_immune_system1.27287180
62MP0006035_abnormal_mitochondrial_morpho1.25788814
63MP0005410_abnormal_fertilization1.25737549
64MP0001730_embryonic_growth_arrest1.24647800
65MP0000372_irregular_coat_pigmentation1.23976219
66MP0003941_abnormal_skin_development1.23214531
67MP0006072_abnormal_retinal_apoptosis1.21071435
68MP0001905_abnormal_dopamine_level1.20634687
69MP0004147_increased_porphyrin_level1.19748341
70MP0005025_abnormal_response_to1.19647921
71MP0000313_abnormal_cell_death1.19212353
72MP0001764_abnormal_homeostasis1.18914304
73MP0001800_abnormal_humoral_immune1.17817862
74MP0004381_abnormal_hair_follicle1.17775682
75MP0002420_abnormal_adaptive_immunity1.17696564
76MP0002723_abnormal_immune_serum1.17449405
77MP0001819_abnormal_immune_cell1.16432187
78MP0001542_abnormal_bone_strength1.15885029
79MP0003136_yellow_coat_color1.14339766
80MP0000716_abnormal_immune_system1.14013593
81MP0005332_abnormal_amino_acid1.13689375
82MP0005377_hearing/vestibular/ear_phenot1.11743541
83MP0003878_abnormal_ear_physiology1.11743541
84MP0009046_muscle_twitch1.09789283
85MP0002429_abnormal_blood_cell1.09464252
86MP0000350_abnormal_cell_proliferation1.09247573
87MP0006082_CNS_inflammation1.09201803
88MP0002019_abnormal_tumor_incidence1.09155120
89MP0001984_abnormal_olfaction1.09126198
90MP0005000_abnormal_immune_tolerance1.08810812
91MP0004043_abnormal_pH_regulation1.07785489
92MP0002452_abnormal_antigen_presenting1.07719459
93MP0000015_abnormal_ear_pigmentation1.07621911
94MP0002210_abnormal_sex_determination1.03425430
95MP0000631_abnormal_neuroendocrine_gland1.01659796
96MP0000685_abnormal_immune_system1.01411166
97MP0005360_urolithiasis1.00325138
98MP0003866_abnormal_defecation1.00032820
99MP0000703_abnormal_thymus_morphology0.99502532
100MP0006276_abnormal_autonomic_nervous0.98834218
101MP0002405_respiratory_system_inflammati0.97407149
102MP0005379_endocrine/exocrine_gland_phen0.96241489
103MP0005670_abnormal_white_adipose0.95873393
104MP0005174_abnormal_tail_pigmentation0.95189843
105MP0002095_abnormal_skin_pigmentation0.94222741
106MP0000358_abnormal_cell_content/0.93817173
107MP0004133_heterotaxia0.90820793
108MP0001929_abnormal_gametogenesis0.88163857
109MP0002234_abnormal_pharynx_morphology0.87120520
110MP0001145_abnormal_male_reproductive0.86858423
111MP0005636_abnormal_mineral_homeostasis0.86715678
112MP0000858_altered_metastatic_potential0.83967197
113MP0002080_prenatal_lethality0.82582606
114MP0005058_abnormal_lysosome_morphology0.82277193
115MP0002160_abnormal_reproductive_system0.81312195
116MP0005389_reproductive_system_phenotype0.80904219
117MP0005171_absent_coat_pigmentation0.79660709
118MP0003252_abnormal_bile_duct0.79327227
119MP0001324_abnormal_eye_pigmentation0.79098527
120MP0001697_abnormal_embryo_size0.78938562
121MP0009745_abnormal_behavioral_response0.78603816
122MP0003698_abnormal_male_reproductive0.77310238
123MP0005395_other_phenotype0.77011249
124MP0002419_abnormal_innate_immunity0.76970672
125MP0003638_abnormal_response/metabolism_0.75994521
126MP0001661_extended_life_span0.75922436
127MP0002638_abnormal_pupillary_reflex0.74860952
128MP0005085_abnormal_gallbladder_physiolo0.74649258
129MP0005408_hypopigmentation0.74389532
130MP0004782_abnormal_surfactant_physiolog0.73642446
131MP0001119_abnormal_female_reproductive0.73144872
132MP0000653_abnormal_sex_gland0.72166996
133MP0008789_abnormal_olfactory_epithelium0.71944425
134MP0002733_abnormal_thermal_nociception0.71925768
135MP0003724_increased_susceptibility_to0.71500045
136MP0000013_abnormal_adipose_tissue0.71126554
137MP0002693_abnormal_pancreas_physiology0.70459014
138MP0002090_abnormal_vision0.69985356
139MP0005083_abnormal_biliary_tract0.69229858
140MP0001919_abnormal_reproductive_system0.68959438
141MP0002928_abnormal_bile_duct0.68723379
142MP0000749_muscle_degeneration0.68090880
143MP0001486_abnormal_startle_reflex0.67907925
144MP0005451_abnormal_body_composition0.67294328
145MP0005386_behavior/neurological_phenoty0.66553735
146MP0004924_abnormal_behavior0.66553735
147MP0002735_abnormal_chemical_nociception0.65155871
148MP0001970_abnormal_pain_threshold0.64969080
149MP0000026_abnormal_inner_ear0.64399730
150MP0000566_synostosis0.64233024
151MP0001790_abnormal_immune_system0.63641632
152MP0005387_immune_system_phenotype0.63641632
153MP0003656_abnormal_erythrocyte_physiolo0.63216743
154MP0000681_abnormal_thyroid_gland0.62681393
155MP0009697_abnormal_copulation0.61856327

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)4.73366243
2Birth length less than 3rd percentile (HP:0003561)4.09385509
3Abnormality of cells of the erythroid lineage (HP:0012130)4.01659955
4Abnormal number of erythroid precursors (HP:0012131)4.00570862
5Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.84909612
6Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.67447660
73-Methylglutaconic aciduria (HP:0003535)3.66165599
8Increased hepatocellular lipid droplets (HP:0006565)3.64649672
9Hepatocellular necrosis (HP:0001404)3.62527437
10Breast hypoplasia (HP:0003187)3.59331517
11Mitochondrial inheritance (HP:0001427)3.52889915
12Rough bone trabeculation (HP:0100670)3.42424100
13Carpal bone hypoplasia (HP:0001498)3.33213242
14Type I transferrin isoform profile (HP:0003642)3.32478921
15Hepatic necrosis (HP:0002605)3.26260533
16Increased CSF lactate (HP:0002490)3.24389714
17Lipid accumulation in hepatocytes (HP:0006561)3.21474366
18Decreased electroretinogram (ERG) amplitude (HP:0000654)3.19241949
19Acute necrotizing encephalopathy (HP:0006965)3.13382750
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.12119418
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.12119418
22Increased serum lactate (HP:0002151)3.08380516
23Pancreatic cysts (HP:0001737)3.02510527
24Exertional dyspnea (HP:0002875)3.01718436
25Molar tooth sign on MRI (HP:0002419)3.01193961
26Abnormality of midbrain morphology (HP:0002418)3.01193961
27Type II lissencephaly (HP:0007260)2.93315388
28Pancreatic fibrosis (HP:0100732)2.90727644
29Oral leukoplakia (HP:0002745)2.90289212
30CNS hypomyelination (HP:0003429)2.82157683
31Renal Fanconi syndrome (HP:0001994)2.82110583
32Abnormal mitochondria in muscle tissue (HP:0008316)2.81249141
33Constricted visual fields (HP:0001133)2.79313886
34Aplastic anemia (HP:0001915)2.77415773
35Optic disc pallor (HP:0000543)2.74271071
36Reticulocytopenia (HP:0001896)2.73278160
37True hermaphroditism (HP:0010459)2.72085653
38Respiratory difficulties (HP:0002880)2.69847323
39Premature graying of hair (HP:0002216)2.68827867
40Progressive microcephaly (HP:0000253)2.67270529
41Cerebral edema (HP:0002181)2.66774778
42Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.66460561
43Patellar aplasia (HP:0006443)2.59265537
44Increased intramyocellular lipid droplets (HP:0012240)2.57987988
45Aplasia/Hypoplasia of the sacrum (HP:0008517)2.56003030
46Aplasia/Hypoplasia of the patella (HP:0006498)2.55520105
47Medial flaring of the eyebrow (HP:0010747)2.55386253
48Congenital stationary night blindness (HP:0007642)2.54711770
49Sparse eyelashes (HP:0000653)2.53374664
50Attenuation of retinal blood vessels (HP:0007843)2.53103836
51Generalized aminoaciduria (HP:0002909)2.52310822
52Abnormal trabecular bone morphology (HP:0100671)2.51797964
53Type 2 muscle fiber atrophy (HP:0003554)2.51081260
54Degeneration of anterior horn cells (HP:0002398)2.50463793
55Abnormality of the anterior horn cell (HP:0006802)2.50463793
56Macrocytic anemia (HP:0001972)2.49166633
57Hyperglycinemia (HP:0002154)2.45788449
58IgG deficiency (HP:0004315)2.42825149
59Progressive macrocephaly (HP:0004481)2.39912904
60Lactic acidosis (HP:0003128)2.39602384
61Muscle fiber atrophy (HP:0100295)2.36955617
62Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35640807
63Microretrognathia (HP:0000308)2.34459313
64Acute encephalopathy (HP:0006846)2.33296456
65IgM deficiency (HP:0002850)2.33006659
66Abolished electroretinogram (ERG) (HP:0000550)2.26287096
67Exercise intolerance (HP:0003546)2.25996655
68Secondary amenorrhea (HP:0000869)2.23975231
69Methylmalonic aciduria (HP:0012120)2.23703329
70Poor head control (HP:0002421)2.22058592
71Lethargy (HP:0001254)2.21890337
72Aplasia/hypoplasia of the uterus (HP:0008684)2.21450221
73Petechiae (HP:0000967)2.20992811
74Cleft eyelid (HP:0000625)2.19589611
75Abnormality of the umbilical cord (HP:0010881)2.19017334
76Pancytopenia (HP:0001876)2.17358843
77CNS demyelination (HP:0007305)2.16866010
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16092237
79Abnormal protein N-linked glycosylation (HP:0012347)2.16092237
80Abnormal protein glycosylation (HP:0012346)2.16092237
81Abnormal glycosylation (HP:0012345)2.16092237
82Bone marrow hypocellularity (HP:0005528)2.16072556
83Increased muscle lipid content (HP:0009058)2.15885248
84Progressive muscle weakness (HP:0003323)2.15871749
85Retinal dysplasia (HP:0007973)2.15172170
86Abnormal rod and cone electroretinograms (HP:0008323)2.13441200
87Stomatitis (HP:0010280)2.13347116
88Microvesicular hepatic steatosis (HP:0001414)2.12838514
89Multiple enchondromatosis (HP:0005701)2.11092860
90Nephronophthisis (HP:0000090)2.11061773
91Prolonged neonatal jaundice (HP:0006579)2.11053154
92Pallor (HP:0000980)2.11001281
93Emotional lability (HP:0000712)2.08201891
94Trismus (HP:0000211)2.06335668
95Renal cortical cysts (HP:0000803)2.05941624
96Premature ovarian failure (HP:0008209)2.05517922
97Respiratory failure (HP:0002878)2.04728924
98Short tibia (HP:0005736)2.04319895
99Hypoplasia of the radius (HP:0002984)2.03020012
100Death in infancy (HP:0001522)2.02582379
101Dicarboxylic aciduria (HP:0003215)2.02098279
102Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02098279
103Abnormality of the preputium (HP:0100587)2.01904501
104Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.01362524
105Nephrogenic diabetes insipidus (HP:0009806)2.00676917
106Congenital primary aphakia (HP:0007707)2.00586121
107Abnormality of the renal cortex (HP:0011035)1.99852382
108Aplasia/Hypoplasia involving the musculature (HP:0001460)1.98150028
109Glycosuria (HP:0003076)1.98033962
110Abnormality of urine glucose concentration (HP:0011016)1.98033962
111Ketoacidosis (HP:0001993)1.97931230
112Cellular immunodeficiency (HP:0005374)1.97758255
113Cerebellar dysplasia (HP:0007033)1.96633197
114Aplasia/Hypoplasia of the tibia (HP:0005772)1.96223471
115Absent radius (HP:0003974)1.96156447
116Aplasia involving forearm bones (HP:0009822)1.95268007
117Absent forearm bone (HP:0003953)1.95268007
118Gait imbalance (HP:0002141)1.92879996
119Methylmalonic acidemia (HP:0002912)1.92049831
120Abnormality of serum amino acid levels (HP:0003112)1.91743874
121Delusions (HP:0000746)1.90606724
122Abnormality of renal resorption (HP:0011038)1.90157648
123Lymphoma (HP:0002665)1.90045823
124Hyperalaninemia (HP:0003348)1.88711832
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88711832
126Abnormality of alanine metabolism (HP:0010916)1.88711832
127Abnormality of glycolysis (HP:0004366)1.88414311
128Increased serum pyruvate (HP:0003542)1.88414311
129Split foot (HP:0001839)1.87460073
130Tongue fasciculations (HP:0001308)1.87337994
131Granulocytopenia (HP:0001913)1.86139818
132Abnormal spermatogenesis (HP:0008669)1.84977265
133Sclerocornea (HP:0000647)1.84603158
134Ketosis (HP:0001946)1.83386760
135Reduced antithrombin III activity (HP:0001976)1.83214381
136Stenosis of the external auditory canal (HP:0000402)1.83087723
137Elevated erythrocyte sedimentation rate (HP:0003565)1.82293303
138Absent thumb (HP:0009777)1.79928104
139Pendular nystagmus (HP:0012043)1.78887219
140Abnormality of the ileum (HP:0001549)1.78671378
141Inability to walk (HP:0002540)1.78286841
142Increased IgM level (HP:0003496)1.77784592
143Meckel diverticulum (HP:0002245)1.77747425
144Opisthotonus (HP:0002179)1.77352498
145Hypomagnesemia (HP:0002917)1.76315742
146Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74752885
147Concave nail (HP:0001598)1.74093471
148Abnormal drinking behavior (HP:0030082)1.73221027
149Polydipsia (HP:0001959)1.73221027
150Neutropenia (HP:0001875)1.69753154
151Decreased central vision (HP:0007663)1.69263193
152Leukodystrophy (HP:0002415)1.68201445

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.23075166
2STK164.28142973
3WEE13.62445494
4VRK23.62021557
5MAP4K23.47251497
6NME23.36461810
7EIF2AK12.82335837
8PLK42.66498514
9FRK2.50477896
10TESK22.47129635
11NUAK12.46897077
12IRAK32.29733657
13TSSK62.23074916
14PIM22.19197841
15SRPK12.17070878
16TAOK32.10401591
17EIF2AK32.07928719
18INSRR2.03360331
19VRK12.01868179
20ZAK1.77780773
21ARAF1.59720818
22GRK11.58273941
23KDR1.57266840
24IRAK41.55085291
25BRSK21.54072874
26TRIM281.53229313
27MST41.52022258
28TXK1.47757194
29ACVR1B1.47377503
30CCNB11.44134075
31PLK11.42502721
32MAP4K11.41385058
33NME11.38639268
34PBK1.36860970
35MKNK11.32727691
36BMPR1B1.31529421
37PINK11.28635856
38BRSK11.20747813
39WNK31.20407848
40DYRK31.19549678
41AKT31.16880510
42CSNK1A1L1.14117812
43MKNK21.13685568
44PLK31.12176874
45TTK1.11209854
46NEK21.10558662
47AURKA1.09491605
48BRAF1.08800588
49TLK11.08596213
50CSNK1G11.08432771
51CSNK1G21.06160850
52EPHA21.03525725
53TIE11.01563165
54MAP3K111.00987081
55AURKB1.00210441
56MAP2K70.99549438
57MAPK130.95389024
58DYRK20.93458556
59CDC70.93116627
60PDK20.93027297
61TESK10.92588481
62EIF2AK20.91016669
63ADRBK10.88123108
64NEK10.86153420
65MAP3K120.84159042
66MAPKAPK30.83969274
67MUSK0.81558808
68MAP3K40.81164407
69PHKG10.79922556
70PHKG20.79922556
71LIMK10.79539469
72DAPK10.79157594
73KIT0.76799097
74IKBKB0.76438630
75PKN10.76218119
76CDK70.75901473
77BCKDK0.75332664
78PRKCI0.74659715
79GRK50.73225724
80OXSR10.73159083
81RPS6KB20.72002081
82CHEK20.71827785
83CSNK2A10.69778849
84BLK0.69434411
85ATR0.68137374
86GRK60.67890273
87PIM10.67377584
88IRAK10.64806814
89PRKCQ0.63218688
90IRAK20.62739992
91RPS6KA50.61561766
92CDK80.61552257
93RPS6KA40.60939505
94PASK0.60615420
95GRK70.60554079
96MYLK0.59805045
97NEK60.59326868
98ADRBK20.59048917
99PAK10.58804778
100OBSCN0.58663308
101STK240.56329529
102TBK10.56292807
103ZAP700.55916568
104CSNK2A20.54949729
105CSNK1G30.54756398
106DAPK30.52093305
107MAP3K80.51327127
108MARK30.51236342
109PAK40.51042370
110ABL20.49939812
111PAK30.49596963
112PTK2B0.48798797
113EPHA30.48197950
114CSNK1A10.48127722
115IKBKE0.47997898
116STK40.43916761
117PRKCE0.43666640
118TEC0.42851934
119LYN0.42769024
120CDK30.42349097
121WNK40.41391501
122CLK10.39374693
123ITK0.39331556
124MAPKAPK50.39034134
125TNK20.38889391
126ILK0.37881551
127CHEK10.37538516
128MATK0.37056050
129MAP2K60.37049916
130NEK90.37044788
131YES10.36993733
132BTK0.36877291
133TAF10.36224759
134FES0.36165662
135TAOK20.35841890
136CDK190.34921253
137SYK0.34747874
138LCK0.34318748
139SIK30.33689667
140PRKACA0.32790391
141CAMK2G0.31947138
142BCR0.31195414
143PIK3CG0.31087959
144MAP2K30.30921990
145MAP3K30.30633916

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.89438677
2RNA polymerase_Homo sapiens_hsa030204.39231590
3Ribosome_Homo sapiens_hsa030104.06857692
4DNA replication_Homo sapiens_hsa030303.79430751
5Mismatch repair_Homo sapiens_hsa034303.26820781
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.18725775
7Pyrimidine metabolism_Homo sapiens_hsa002402.84705494
8Base excision repair_Homo sapiens_hsa034102.63319289
9Spliceosome_Homo sapiens_hsa030402.63097019
10Homologous recombination_Homo sapiens_hsa034402.53999260
11Nucleotide excision repair_Homo sapiens_hsa034202.48845242
12Oxidative phosphorylation_Homo sapiens_hsa001902.31158487
13RNA transport_Homo sapiens_hsa030132.30822578
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.14246367
15Protein export_Homo sapiens_hsa030602.08273695
16Parkinsons disease_Homo sapiens_hsa050122.06741749
17Vitamin B6 metabolism_Homo sapiens_hsa007501.98603650
18Basal transcription factors_Homo sapiens_hsa030221.84474513
19Purine metabolism_Homo sapiens_hsa002301.75395290
20Huntingtons disease_Homo sapiens_hsa050161.69553641
21Cell cycle_Homo sapiens_hsa041101.63415604
22Sulfur metabolism_Homo sapiens_hsa009201.61318873
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53358858
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.45039510
25Butanoate metabolism_Homo sapiens_hsa006501.43434572
26Fanconi anemia pathway_Homo sapiens_hsa034601.43427986
27RNA degradation_Homo sapiens_hsa030181.40135837
28Regulation of autophagy_Homo sapiens_hsa041401.38580079
29Peroxisome_Homo sapiens_hsa041461.37742928
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33030409
31Primary immunodeficiency_Homo sapiens_hsa053401.30778320
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30019841
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28177249
34Folate biosynthesis_Homo sapiens_hsa007901.27066149
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26849823
36Non-homologous end-joining_Homo sapiens_hsa034501.25843257
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.25491151
38Alzheimers disease_Homo sapiens_hsa050101.21234772
39Epstein-Barr virus infection_Homo sapiens_hsa051691.17407133
40Propanoate metabolism_Homo sapiens_hsa006401.12645005
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11657232
42Nitrogen metabolism_Homo sapiens_hsa009101.10667968
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08755628
44Pentose phosphate pathway_Homo sapiens_hsa000301.07927222
45p53 signaling pathway_Homo sapiens_hsa041151.06279235
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05488931
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04428077
48Sulfur relay system_Homo sapiens_hsa041220.97054593
49Tryptophan metabolism_Homo sapiens_hsa003800.96597366
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93581633
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92485953
52Antigen processing and presentation_Homo sapiens_hsa046120.91437971
53Selenocompound metabolism_Homo sapiens_hsa004500.89250639
54One carbon pool by folate_Homo sapiens_hsa006700.88816979
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87743957
56Glutathione metabolism_Homo sapiens_hsa004800.87292954
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86276341
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86114357
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.84308701
60Arachidonic acid metabolism_Homo sapiens_hsa005900.82419850
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.80953112
62Allograft rejection_Homo sapiens_hsa053300.79966177
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78364587
64Fructose and mannose metabolism_Homo sapiens_hsa000510.77210115
65Chemical carcinogenesis_Homo sapiens_hsa052040.70003461
66mRNA surveillance pathway_Homo sapiens_hsa030150.67449683
67Graft-versus-host disease_Homo sapiens_hsa053320.67293915
68Caffeine metabolism_Homo sapiens_hsa002320.66150677
69Steroid biosynthesis_Homo sapiens_hsa001000.65301399
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65222835
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.64732601
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.63150829
73Metabolic pathways_Homo sapiens_hsa011000.62660123
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61063741
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60304476
76Autoimmune thyroid disease_Homo sapiens_hsa053200.59547158
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57805552
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57048874
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56530809
80Other glycan degradation_Homo sapiens_hsa005110.56104551
81Herpes simplex infection_Homo sapiens_hsa051680.55257575
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53540779
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.52740095
84Phototransduction_Homo sapiens_hsa047440.52411372
85Measles_Homo sapiens_hsa051620.47757857
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.46383227
87Galactose metabolism_Homo sapiens_hsa000520.45431254
88Cardiac muscle contraction_Homo sapiens_hsa042600.45266510
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.45102683
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43613652
91Hematopoietic cell lineage_Homo sapiens_hsa046400.42471082
92Asthma_Homo sapiens_hsa053100.41652860
93Legionellosis_Homo sapiens_hsa051340.41123677
94Collecting duct acid secretion_Homo sapiens_hsa049660.40984222
95Retinol metabolism_Homo sapiens_hsa008300.40611918
96Olfactory transduction_Homo sapiens_hsa047400.40333298
97Type I diabetes mellitus_Homo sapiens_hsa049400.39756089
98Arginine and proline metabolism_Homo sapiens_hsa003300.39484361
99Linoleic acid metabolism_Homo sapiens_hsa005910.39268444
100Biosynthesis of amino acids_Homo sapiens_hsa012300.38456636
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38386640
102Rheumatoid arthritis_Homo sapiens_hsa053230.37388940
103Shigellosis_Homo sapiens_hsa051310.37138281
104Alcoholism_Homo sapiens_hsa050340.36711838
105Sphingolipid metabolism_Homo sapiens_hsa006000.34914410
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34025462
107Pyruvate metabolism_Homo sapiens_hsa006200.33927692
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33632744
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33535981
110beta-Alanine metabolism_Homo sapiens_hsa004100.32930431
111Oocyte meiosis_Homo sapiens_hsa041140.32445633
112Systemic lupus erythematosus_Homo sapiens_hsa053220.32300467
113Fatty acid elongation_Homo sapiens_hsa000620.29816888
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28638872
115Viral carcinogenesis_Homo sapiens_hsa052030.26918882
116N-Glycan biosynthesis_Homo sapiens_hsa005100.26631010
117Glycerolipid metabolism_Homo sapiens_hsa005610.26498707
118Fatty acid metabolism_Homo sapiens_hsa012120.26159486
119Carbon metabolism_Homo sapiens_hsa012000.24508187
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.24249845
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23907636
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23749471
123Lysosome_Homo sapiens_hsa041420.23100170
124Ether lipid metabolism_Homo sapiens_hsa005650.22146069
125Apoptosis_Homo sapiens_hsa042100.21671967
126Vibrio cholerae infection_Homo sapiens_hsa051100.19620329
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19513082
128HTLV-I infection_Homo sapiens_hsa051660.19225342
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18311905
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16288009
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15759274
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.14911924
133Leishmaniasis_Homo sapiens_hsa051400.11621287
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08676725
135Influenza A_Homo sapiens_hsa051640.08257543

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