ZMIZ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)3.75860313
2axon extension involved in axon guidance (GO:0048846)3.26454966
3neuron projection extension involved in neuron projection guidance (GO:1902284)3.26454966
4semaphorin-plexin signaling pathway (GO:0071526)3.13474681
5cytoplasmic mRNA processing body assembly (GO:0033962)3.12419704
6positive regulation by symbiont of host defense response (GO:0052509)3.05473121
7modulation by symbiont of host defense response (GO:0052031)3.05473121
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.05473121
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.05473121
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.05473121
11modulation by symbiont of host immune response (GO:0052553)3.05473121
12cell-cell junction maintenance (GO:0045217)3.05420322
13regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.01253033
14lateral sprouting from an epithelium (GO:0060601)2.97605190
15insulin-like growth factor receptor signaling pathway (GO:0048009)2.91087778
16G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.89944849
17coronary vasculature morphogenesis (GO:0060977)2.87141732
18planar cell polarity pathway involved in neural tube closure (GO:0090179)2.84510710
19regulation of NFAT protein import into nucleus (GO:0051532)2.82360858
20NLS-bearing protein import into nucleus (GO:0006607)2.71274303
21histone H3-K4 trimethylation (GO:0080182)2.66463363
22stress fiber assembly (GO:0043149)2.65592379
23protein localization to endosome (GO:0036010)2.64794846
24nerve growth factor signaling pathway (GO:0038180)2.64168744
25endothelial cell chemotaxis (GO:0035767)2.62107854
26skin morphogenesis (GO:0043589)2.59172214
27positive regulation of histone deacetylation (GO:0031065)2.54614459
28neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.47956356
29substrate-dependent cell migration (GO:0006929)2.47893887
30barbed-end actin filament capping (GO:0051016)2.47379930
31glial cell proliferation (GO:0014009)2.46980819
32negative regulation of catenin import into nucleus (GO:0035414)2.46828218
33cell junction maintenance (GO:0034331)2.46477810
34dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.41992499
35establishment of nucleus localization (GO:0040023)2.41192303
36nucleosome disassembly (GO:0006337)2.39505774
37protein-DNA complex disassembly (GO:0032986)2.39505774
38positive regulation of axon extension (GO:0045773)2.38952870
39response to laminar fluid shear stress (GO:0034616)2.36504103
40negative regulation of granulocyte differentiation (GO:0030853)2.36045308
41neuron recognition (GO:0008038)2.35870904
42cerebellar granule cell differentiation (GO:0021707)2.35279864
43camera-type eye morphogenesis (GO:0048593)2.34337363
44cell proliferation involved in metanephros development (GO:0072203)2.34149763
45negative regulation of glial cell proliferation (GO:0060253)2.32823289
46hippo signaling (GO:0035329)2.32136073
47central nervous system projection neuron axonogenesis (GO:0021952)2.31573716
48regulation of axon extension involved in axon guidance (GO:0048841)2.31060024
49regulation of ARF protein signal transduction (GO:0032012)2.30850510
50postsynaptic membrane organization (GO:0001941)2.30800463
51regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.29458080
52epithelial cell differentiation involved in prostate gland development (GO:0060742)2.27998276
53cellular response to nerve growth factor stimulus (GO:1990090)2.27362805
54response to nerve growth factor (GO:1990089)2.27362805
55layer formation in cerebral cortex (GO:0021819)2.27006028
56Notch signaling involved in heart development (GO:0061314)2.24753571
57cellular response to monoamine stimulus (GO:0071868)2.24658507
58cellular response to catecholamine stimulus (GO:0071870)2.24658507
59cell migration involved in heart development (GO:0060973)2.23984517
60regulation of establishment of planar polarity (GO:0090175)2.23394455
61negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.22938191
62cellular response to prostaglandin stimulus (GO:0071379)2.22812993
63negative regulation of axon extension involved in axon guidance (GO:0048843)2.22510236
64glucocorticoid receptor signaling pathway (GO:0042921)2.22444249
65regulation of histone deacetylation (GO:0031063)2.22332317
66regulation of axon guidance (GO:1902667)2.21181499
67regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.20446051
68positive regulation of epithelial to mesenchymal transition (GO:0010718)2.20131503
69negative regulation of cell killing (GO:0031342)2.19417999
70negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.19417999
71negative regulation of translation, ncRNA-mediated (GO:0040033)2.19066604
72regulation of translation, ncRNA-mediated (GO:0045974)2.19066604
73negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.19066604
74embryonic retina morphogenesis in camera-type eye (GO:0060059)2.18515146
75cytoskeletal anchoring at plasma membrane (GO:0007016)2.17811933
76cortical actin cytoskeleton organization (GO:0030866)2.17208706
77response to peptidoglycan (GO:0032494)2.16529554
78mannose metabolic process (GO:0006013)2.15334942
79ionotropic glutamate receptor signaling pathway (GO:0035235)2.15026322
80negative regulation of Ras protein signal transduction (GO:0046580)2.14878473
81renal system development (GO:0072001)2.14541255
82positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.14217814
83macrophage activation involved in immune response (GO:0002281)2.13148152
84histone H3-K4 methylation (GO:0051568)2.12819347
85endocardial cushion morphogenesis (GO:0003203)2.12124649
86regulation of early endosome to late endosome transport (GO:2000641)2.11929537
87response to muramyl dipeptide (GO:0032495)2.11248045
88Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.09962237
89negative regulation of axon guidance (GO:1902668)2.08797932
90positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.08534040
91neuromuscular process controlling balance (GO:0050885)2.08496238
92negative regulation of small GTPase mediated signal transduction (GO:0051058)2.08362286
93germ cell migration (GO:0008354)2.07860051
94regulation of protein deacetylation (GO:0090311)2.07442368
95lens fiber cell development (GO:0070307)2.07273204
96presynaptic membrane assembly (GO:0097105)2.06218611
97clathrin coat assembly (GO:0048268)2.06118633
98I-kappaB phosphorylation (GO:0007252)2.05658391
99response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.05427980
100response to host (GO:0075136)2.05427980
101response to host defenses (GO:0052200)2.05427980
102regulation of interferon-beta biosynthetic process (GO:0045357)2.05150752
103positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.04809953
104heart valve formation (GO:0003188)2.04585808
105regulation of ARF GTPase activity (GO:0032312)2.04244529
106regulation of leukocyte degranulation (GO:0043300)2.04010478
107positive regulation of receptor recycling (GO:0001921)2.03345530
108fibroblast migration (GO:0010761)2.02884492
109* heart morphogenesis (GO:0003007)2.02852297
110gastrulation with mouth forming second (GO:0001702)2.02805737
111cortical cytoskeleton organization (GO:0030865)2.02779267
112cellular response to thyroid hormone stimulus (GO:0097067)2.01687612
113corticosteroid receptor signaling pathway (GO:0031958)2.01680641
114axonal fasciculation (GO:0007413)2.01635906
115craniofacial suture morphogenesis (GO:0097094)2.01476931
116dendrite morphogenesis (GO:0048813)2.01387185
117suckling behavior (GO:0001967)2.01192927
118embryonic camera-type eye morphogenesis (GO:0048596)2.00388575
119neuronal stem cell maintenance (GO:0097150)2.00251034
120neuron projection extension (GO:1990138)1.99929594
121response to fluid shear stress (GO:0034405)1.99694687
122regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.99377739
123neuron remodeling (GO:0016322)1.99366391
124apical protein localization (GO:0045176)1.99102298
125pyrimidine nucleobase catabolic process (GO:0006208)1.98237029
126mating behavior (GO:0007617)1.98117868
127dopamine receptor signaling pathway (GO:0007212)1.97905264
128positive regulation of extracellular matrix organization (GO:1903055)1.97828716
129cellular response to vascular endothelial growth factor stimulus (GO:0035924)1.97508019
130spinal cord development (GO:0021510)1.96915381
131presynaptic membrane organization (GO:0097090)1.96680603
132cell migration in hindbrain (GO:0021535)1.96456479
133atrial septum morphogenesis (GO:0060413)1.96283691
134venous blood vessel morphogenesis (GO:0048845)1.96063340
135regulation of interleukin-12 biosynthetic process (GO:0045075)1.95692253
136cellular response to fluid shear stress (GO:0071498)1.95537270
137chondroitin sulfate biosynthetic process (GO:0030206)1.94974545
138dendritic spine morphogenesis (GO:0060997)1.94109972
139regulation of phosphatidylinositol 3-kinase activity (GO:0043551)1.93608160
140vascular endothelial growth factor signaling pathway (GO:0038084)1.93260860
141regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00431.92658762
142ganglion development (GO:0061548)1.92382452
143regulation of T cell tolerance induction (GO:0002664)1.91653880
144positive regulation of gene expression, epigenetic (GO:0045815)1.91340257
145axon extension (GO:0048675)1.91201221
146peptidyl-lysine trimethylation (GO:0018023)1.91013732
147epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)1.90940733
148eye morphogenesis (GO:0048592)1.90671892
149response to monoamine (GO:0071867)1.90648781
150response to catecholamine (GO:0071869)1.90648781
151negative regulation of smooth muscle cell migration (GO:0014912)1.90284557
152mesenchymal-epithelial cell signaling (GO:0060638)1.90062899
153negative regulation of neurotransmitter secretion (GO:0046929)1.89908025
154plasma membrane repair (GO:0001778)1.89665787
155cell proliferation in forebrain (GO:0021846)1.89650585
156growth hormone receptor signaling pathway (GO:0060396)1.89476156
157embryonic viscerocranium morphogenesis (GO:0048703)1.89107222
158aorta morphogenesis (GO:0035909)1.88399098
159chondrocyte proliferation (GO:0035988)1.88347910
160cranial nerve morphogenesis (GO:0021602)1.88251795
161regulation of macrophage cytokine production (GO:0010935)1.88028764
162negative regulation of chondrocyte differentiation (GO:0032331)1.87735270
163radial glial cell differentiation (GO:0060019)1.87484383
164response to immune response of other organism involved in symbiotic interaction (GO:0052564)1.87245975
165response to host immune response (GO:0052572)1.87245975
166locomotory exploration behavior (GO:0035641)1.86542674
167negative regulation of fatty acid transport (GO:2000192)1.86314389
168vascular endothelial growth factor receptor signaling pathway (GO:0048010)1.86119015

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.06825329
2* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.99858550
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.60591512
4EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.52599075
5* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.38686913
6* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.32483987
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.25971347
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11263538
9MYC_22102868_ChIP-Seq_BL_Human2.08772084
10* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.08659230
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06224762
12* KDM2B_26808549_Chip-Seq_DND41_Human2.05729905
13EZH2_22144423_ChIP-Seq_EOC_Human2.05666323
14* TCF7_22412390_ChIP-Seq_EML_Mouse2.01720817
15DROSHA_22980978_ChIP-Seq_HELA_Human1.95385106
16DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.92909840
17TP63_19390658_ChIP-ChIP_HaCaT_Human1.91517615
18* KDM2B_26808549_Chip-Seq_K562_Human1.87157700
19* KDM2B_26808549_Chip-Seq_JURKAT_Human1.72666028
20* VDR_21846776_ChIP-Seq_THP-1_Human1.70176146
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69345100
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.68630817
23* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.67945813
24* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67186224
25* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67002580
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66591357
27SCL_19346495_ChIP-Seq_HPC-7_Human1.64849375
28* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64210385
29* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64210385
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61488445
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.59716372
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58695833
33* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58065137
34AHR_22903824_ChIP-Seq_MCF-7_Human1.57584010
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57171087
36NFIB_24661679_ChIP-Seq_LUNG_Mouse1.56653648
37* VDR_24763502_ChIP-Seq_THP-1_Human1.55739967
38* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55358745
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.55081763
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.53661544
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50963156
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.48775130
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48132572
44* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47270223
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.46049832
46* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.43834709
47* SPI1_23127762_ChIP-Seq_K562_Human1.42978308
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41121620
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38139031
50* VDR_24787735_ChIP-Seq_THP-1_Human1.36911170
51* ISL1_27105846_Chip-Seq_CPCs_Mouse1.36807985
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35407876
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.35269149
54RUNX_20019798_ChIP-Seq_JUKART_Human1.35165701
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.34470877
56* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34169038
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33039977
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32086602
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31480746
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30656849
61* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28867773
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28135307
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.27708839
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27498688
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24476576
66* TP53_20018659_ChIP-ChIP_R1E_Mouse1.23891591
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.23079563
68CLOCK_20551151_ChIP-Seq_293T_Human1.22574045
69FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.22048185
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.20333944
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20187744
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.20045822
73* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19718601
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.18997301
75NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17332893
76LXR_22292898_ChIP-Seq_THP-1_Human1.16430183
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16293975
78* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15632963
79* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15210924
80* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13498253
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13433908
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13396774
83* EZH2_27304074_Chip-Seq_ESCs_Mouse1.12201929
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11776241
85* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11474154
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10101186
87* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09811125
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08154161
89* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07776445
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07314089
91* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07091420
92* RACK7_27058665_Chip-Seq_MCF-7_Human1.06379943
93* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05921877
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.05697932
95* EZH2_27294783_Chip-Seq_ESCs_Mouse1.04096001
96* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03538079
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03494708
98CDX2_20551321_ChIP-Seq_CACO-2_Human1.02891348
99* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02452080
100* RING1B_27294783_Chip-Seq_ESCs_Mouse1.02008155
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01685049
102ESR1_21235772_ChIP-Seq_MCF-7_Human1.00879889
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00132072
104GATA2_21666600_ChIP-Seq_HMVEC_Human0.99734966
105* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99252332
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98786622
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98744525
108RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98662559
109TBX20_22080862_ChIP-Seq_HEART_Mouse0.97350632
110TBX20_22328084_ChIP-Seq_HEART_Mouse0.97350632
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96100050
112UTX_26944678_Chip-Seq_JUKART_Human0.95994620
113* GATA1_19941827_ChIP-Seq_MEL_Mouse0.95705049
114MAF_26560356_Chip-Seq_TH1_Human0.95548821
115* CBX2_27304074_Chip-Seq_ESCs_Mouse0.95195072
116WT1_19549856_ChIP-ChIP_CCG9911_Human0.93128935
117CREB1_26743006_Chip-Seq_LNCaP_Human0.92841258
118* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92477206
119RUNX1_27514584_Chip-Seq_MCF-7_Human0.92349036
120* REST_21632747_ChIP-Seq_MESCs_Mouse0.91818020
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89062350
122* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88801742
123ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87648756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.30297384
2MP0005409_darkened_coat_color3.15947388
3MP0005076_abnormal_cell_differentiation2.75969193
4MP0009278_abnormal_bone_marrow2.59005635
5MP0003705_abnormal_hypodermis_morpholog2.51331518
6MP0005058_abnormal_lysosome_morphology2.33514934
7MP0005257_abnormal_intraocular_pressure2.13746283
8MP0005423_abnormal_somatic_nervous2.13741393
9MP0003300_gastrointestinal_ulcer2.05203033
10MP0003329_amyloid_beta_deposits1.95992491
11MP0003303_peritoneal_inflammation1.93099760
12MP0000733_abnormal_muscle_development1.88268214
13MP0008961_abnormal_basal_metabolism1.77461894
14MP0000537_abnormal_urethra_morphology1.75826992
15MP0003634_abnormal_glial_cell1.65976523
16MP0003690_abnormal_glial_cell1.63619584
17MP0005187_abnormal_penis_morphology1.63480471
18MP0000604_amyloidosis1.63061264
19MP0004808_abnormal_hematopoietic_stem1.58167371
20MP0002877_abnormal_melanocyte_morpholog1.53762071
21MP0000428_abnormal_craniofacial_morphol1.52839414
22MP0002822_catalepsy1.51402920
23MP0003091_abnormal_cell_migration1.51059504
24MP0005248_abnormal_Harderian_gland1.50855320
25MP0000778_abnormal_nervous_system1.50585234
26MP0005275_abnormal_skin_tensile1.49812753
27MP0009780_abnormal_chondrocyte_physiolo1.48829290
28MP0004270_analgesia1.48260976
29MP0009053_abnormal_anal_canal1.48129281
30MP0010368_abnormal_lymphatic_system1.47280847
31MP0001958_emphysema1.45660418
32MP0003279_aneurysm1.45040149
33MP0003172_abnormal_lysosome_physiology1.44354617
34MP0005174_abnormal_tail_pigmentation1.43803910
35MP0003385_abnormal_body_wall1.42772389
36MP0004858_abnormal_nervous_system1.39690472
37MP0003635_abnormal_synaptic_transmissio1.38557323
38MP0003436_decreased_susceptibility_to1.38265579
39MP0000767_abnormal_smooth_muscle1.38088261
40MP0002089_abnormal_postnatal_growth/wei1.36312800
41MP0010030_abnormal_orbit_morphology1.36014161
42MP0001879_abnormal_lymphatic_vessel1.34259681
43MP0001299_abnormal_eye_distance/1.32767631
44MP0000566_synostosis1.32399209
45MP0004510_myositis1.29753256
46MP0003122_maternal_imprinting1.28412894
47MP0003183_abnormal_peptide_metabolism1.27707684
48* MP0003935_abnormal_craniofacial_develop1.26813341
49MP0005503_abnormal_tendon_morphology1.24616599
50MP0003566_abnormal_cell_adhesion1.24454504
51MP0003115_abnormal_respiratory_system1.23083510
52MP0004885_abnormal_endolymph1.22869763
53MP0002653_abnormal_ependyma_morphology1.22360401
54MP0002063_abnormal_learning/memory/cond1.22129058
55MP0010352_gastrointestinal_tract_polyps1.21190837
56MP0002116_abnormal_craniofacial_bone1.19461161
57MP0002249_abnormal_larynx_morphology1.18617723
58MP0003283_abnormal_digestive_organ1.17502439
59MP0002282_abnormal_trachea_morphology1.16908740
60MP0001849_ear_inflammation1.16522187
61MP0000920_abnormal_myelination1.15315555
62MP0002938_white_spotting1.15146119
63* MP0002925_abnormal_cardiovascular_devel1.15043597
64MP0005670_abnormal_white_adipose1.13910200
65MP0003828_pulmonary_edema1.13408441
66MP0002998_abnormal_bone_remodeling1.10214023
67MP0002396_abnormal_hematopoietic_system1.08534913
68MP0008438_abnormal_cutaneous_collagen1.08191417
69MP0002735_abnormal_chemical_nociception1.06605940
70MP0003045_fibrosis1.06053374
71MP0009840_abnormal_foam_cell1.05892075
72MP0005666_abnormal_adipose_tissue1.05460828
73MP0004272_abnormal_basement_membrane1.05162921
74MP0005508_abnormal_skeleton_morphology1.04471454
75MP0002896_abnormal_bone_mineralization1.03797245
76MP0009250_abnormal_appendicular_skeleto1.03734788
77MP0003942_abnormal_urinary_system1.02155385
78MP0008569_lethality_at_weaning1.01790345
79MP0003075_altered_response_to1.00052324
80MP0005623_abnormal_meninges_morphology0.99966335
81MP0003861_abnormal_nervous_system0.98774767
82MP0001293_anophthalmia0.98152238
83MP0000534_abnormal_ureter_morphology0.97810380
84MP0000955_abnormal_spinal_cord0.96746286
85MP0000049_abnormal_middle_ear0.95944403
86MP0002092_abnormal_eye_morphology0.95942058
87MP0004811_abnormal_neuron_physiology0.95754287
88MP0003755_abnormal_palate_morphology0.95044561
89MP0000383_abnormal_hair_follicle0.94761874
90MP0010630_abnormal_cardiac_muscle0.94031211
91MP0003453_abnormal_keratinocyte_physiol0.93995371
92MP0002009_preneoplasia0.93987908
93MP0003567_abnormal_fetal_cardiomyocyte0.92071028
94MP0008789_abnormal_olfactory_epithelium0.91798890
95MP0003121_genomic_imprinting0.90653860
96MP0002932_abnormal_joint_morphology0.90524275
97MP0001440_abnormal_grooming_behavior0.89536043
98MP0002113_abnormal_skeleton_development0.88516026
99MP0000432_abnormal_head_morphology0.87713988
100MP0003948_abnormal_gas_homeostasis0.87237195
101MP0002572_abnormal_emotion/affect_behav0.85493754
102MP0005394_taste/olfaction_phenotype0.84950151
103MP0005499_abnormal_olfactory_system0.84950151
104MP0002064_seizures0.84556636
105MP0004947_skin_inflammation0.84484920
106MP0005595_abnormal_vascular_smooth0.84344989
107MP0000516_abnormal_urinary_system0.84303891
108MP0005367_renal/urinary_system_phenotyp0.84303891
109MP0005375_adipose_tissue_phenotype0.84288668
110MP0005390_skeleton_phenotype0.83276082
111MP0005167_abnormal_blood-brain_barrier0.83257223
112MP0002152_abnormal_brain_morphology0.82747223
113MP0001545_abnormal_hematopoietic_system0.82607930
114MP0005397_hematopoietic_system_phenotyp0.82607930
115MP0002734_abnormal_mechanical_nocicepti0.82190839
116MP0003787_abnormal_imprinting0.81758205
117MP0001533_abnormal_skeleton_physiology0.81607442
118MP0003191_abnormal_cellular_cholesterol0.81494494
119MP0000465_gastrointestinal_hemorrhage0.80124618
120MP0000003_abnormal_adipose_tissue0.80095745
121MP0002108_abnormal_muscle_morphology0.79792577
122MP0001915_intracranial_hemorrhage0.79755294
123MP0004859_abnormal_synaptic_plasticity0.79199664
124MP0002882_abnormal_neuron_morphology0.78991596
125MP0003632_abnormal_nervous_system0.78832294
126MP0001502_abnormal_circadian_rhythm0.78348836
127MP0002933_joint_inflammation0.78304395
128MP0000371_diluted_coat_color0.78044150
129MP0002419_abnormal_innate_immunity0.77239505
130MP0002234_abnormal_pharynx_morphology0.76895053
131MP0002115_abnormal_skeleton_extremities0.76597337
132MP0000163_abnormal_cartilage_morphology0.76034876
133MP0002184_abnormal_innervation0.75346499
134MP0002128_abnormal_blood_circulation0.73724194
135* MP0000266_abnormal_heart_morphology0.73675317
136MP0004134_abnormal_chest_morphology0.73664095
137MP0002109_abnormal_limb_morphology0.73654825
138* MP0001614_abnormal_blood_vessel0.72968677
139MP0003633_abnormal_nervous_system0.72517887
140MP0002733_abnormal_thermal_nociception0.71157677
141MP0010307_abnormal_tumor_latency0.69989033
142MP0001175_abnormal_lung_morphology0.69865964
143MP0001970_abnormal_pain_threshold0.69457320
144MP0002177_abnormal_outer_ear0.67763377
145MP0001177_atelectasis0.67553117
146MP0001784_abnormal_fluid_regulation0.67422869
147MP0002452_abnormal_antigen_presenting0.66459557
148MP0001486_abnormal_startle_reflex0.66402561
149MP0002081_perinatal_lethality0.66395709
150MP0009115_abnormal_fat_cell0.66031691
151MP0005388_respiratory_system_phenotype0.66011064
152MP0002133_abnormal_respiratory_system0.66011064

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.07012692
2Short 4th metacarpal (HP:0010044)4.07012692
3Shallow orbits (HP:0000586)3.67243711
4Neurofibrillary tangles (HP:0002185)3.37849542
5Trigonocephaly (HP:0000243)3.19438258
6Abnormality of the 4th metacarpal (HP:0010012)3.16334452
7Macroorchidism (HP:0000053)2.95454451
8Hyperacusis (HP:0010780)2.90017288
9Cerebral aneurysm (HP:0004944)2.72524105
10Neonatal short-limb short stature (HP:0008921)2.69862010
11Narrow palate (HP:0000189)2.63943943
12Cerebral inclusion bodies (HP:0100314)2.61826204
13Abnormality of the fingertips (HP:0001211)2.54129285
14Broad metatarsal (HP:0001783)2.47803975
15Dysostosis multiplex (HP:0000943)2.36692671
16Midline defect of the nose (HP:0004122)2.35262550
17Supranuclear gaze palsy (HP:0000605)2.35141531
18Elfin facies (HP:0004428)2.32128681
19Genetic anticipation (HP:0003743)2.29340909
20Abnormality of liposaccharide metabolism (HP:0010968)2.29268768
21Abnormality of glycosphingolipid metabolism (HP:0004343)2.29268768
22Abnormality of glycolipid metabolism (HP:0010969)2.29268768
23Arterial tortuosity (HP:0005116)2.26150370
24Renal duplication (HP:0000075)2.26089648
25Nuclear cataract (HP:0100018)2.24899978
26Long eyelashes (HP:0000527)2.23827519
27Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.20401583
28Aortic aneurysm (HP:0004942)2.16083628
29Abnormality of the nasal septum (HP:0000419)2.15163621
30Urethral obstruction (HP:0000796)2.14800859
31Syringomyelia (HP:0003396)2.13046385
32Spinal cord lesions (HP:0100561)2.13046385
33Exostoses (HP:0100777)2.11935759
34Aqueductal stenosis (HP:0002410)2.07229767
35Increased density of long bones (HP:0006392)2.05687456
36Neoplasm of the heart (HP:0100544)2.05597106
37Asymmetry of the thorax (HP:0001555)2.04464231
38Renovascular hypertension (HP:0100817)2.03892231
39Overriding aorta (HP:0002623)2.03554275
40Vascular tortuosity (HP:0004948)2.03026299
41Abnormality of the parietal bone (HP:0002696)2.02553461
42Abnormality of the intervertebral disk (HP:0005108)2.02285879
43Urinary glycosaminoglycan excretion (HP:0003541)2.01597469
44Mucopolysacchariduria (HP:0008155)2.01597469
45Hematochezia (HP:0002573)2.01596183
46Apathy (HP:0000741)2.00149790
47Premature rupture of membranes (HP:0001788)1.99633391
48Neuronal loss in central nervous system (HP:0002529)1.99605712
49Disinhibition (HP:0000734)1.99232705
50Wide anterior fontanel (HP:0000260)1.98832860
51Disproportionate tall stature (HP:0001519)1.98610907
52Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98329705
53Abnormality of polysaccharide metabolism (HP:0011012)1.98329705
54Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98329705
55Mitral regurgitation (HP:0001653)1.97676157
56Thin bony cortex (HP:0002753)1.96387378
57Dilatation of the ascending aorta (HP:0005111)1.94691532
58Deviation of the hallux (HP:0010051)1.92897856
59Enlarged penis (HP:0000040)1.91934831
60Mitral valve prolapse (HP:0001634)1.91869589
61Turricephaly (HP:0000262)1.88213523
62Overgrowth (HP:0001548)1.87809505
63Hypoventilation (HP:0002791)1.87682848
64Uterine leiomyosarcoma (HP:0002891)1.87569020
65Leiomyosarcoma (HP:0100243)1.87569020
66Diminished motivation (HP:0000745)1.87401323
67Heterotopia (HP:0002282)1.87082248
68Bronchomalacia (HP:0002780)1.85687118
69Broad thumb (HP:0011304)1.84475520
70Abnormality of binocular vision (HP:0011514)1.84027633
71Diplopia (HP:0000651)1.84027633
72Flat cornea (HP:0007720)1.83461613
73Hallux valgus (HP:0001822)1.82900230
74Protrusio acetabuli (HP:0003179)1.82167077
75Absent frontal sinuses (HP:0002688)1.82155935
76Wormian bones (HP:0002645)1.81842048
77Thick eyebrow (HP:0000574)1.81679020
78Spondylolisthesis (HP:0003302)1.81043066
79Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.80413035
80Anteriorly placed anus (HP:0001545)1.78479841
81Deformed sella turcica (HP:0002681)1.78353435
82Bladder diverticulum (HP:0000015)1.77558945
83Transitional cell carcinoma of the bladder (HP:0006740)1.77526600
84Cervical subluxation (HP:0003308)1.76897922
85Mutism (HP:0002300)1.76679443
86Aortic dissection (HP:0002647)1.76274382
87Obsessive-compulsive behavior (HP:0000722)1.75055781
88Insomnia (HP:0100785)1.74905922
89Hyperextensible skin (HP:0000974)1.73477481
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72707335
91Buphthalmos (HP:0000557)1.72356115
92Broad ribs (HP:0000885)1.72065265
93Pointed chin (HP:0000307)1.71634351
94Abnormality of the diencephalon (HP:0010662)1.71118134
95Increased nuchal translucency (HP:0010880)1.69256010
96Vertebral arch anomaly (HP:0008438)1.68710962
97Mild short stature (HP:0003502)1.67552132
98Morphological abnormality of the middle ear (HP:0008609)1.67510035
99Atrophic scars (HP:0001075)1.67016148
100Broad hallux (HP:0010055)1.65637846
101Hypoplastic ischia (HP:0003175)1.65404537
102Lymphangioma (HP:0100764)1.65074823
103Abnormality of the right ventricle (HP:0001707)1.63856945
104Stereotypic behavior (HP:0000733)1.63728072
105Increased neuronal autofluorescent lipopigment (HP:0002074)1.63070030
106Genu recurvatum (HP:0002816)1.62914092
107Hypoplasia of the maxilla (HP:0000327)1.62819405
108Inappropriate behavior (HP:0000719)1.62378643
109Arnold-Chiari malformation (HP:0002308)1.62093675
110Smooth philtrum (HP:0000319)1.62007327
111Bowel diverticulosis (HP:0005222)1.60573911
112Abnormality of the distal phalanx of the thumb (HP:0009617)1.60268725
113Short philtrum (HP:0000322)1.59581348
114Onion bulb formation (HP:0003383)1.59362457
115Broad face (HP:0000283)1.59337579
116Bladder carcinoma (HP:0002862)1.59316677
117Bladder neoplasm (HP:0009725)1.59316677
118Increased cerebral lipofuscin (HP:0011813)1.59066607
119Short phalanx of the thumb (HP:0009660)1.58024020
120Dental malocclusion (HP:0000689)1.57833985
121Precocious puberty (HP:0000826)1.57633360
122Wrist flexion contracture (HP:0001239)1.57465772
123Abnormality of the ischium (HP:0003174)1.57439258
124Annular pancreas (HP:0001734)1.57204191
125Aneurysm (HP:0002617)1.56826287
126Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.56787115
127Cutis marmorata (HP:0000965)1.56409478
128Ulnar bowing (HP:0003031)1.55528832
129Peritonitis (HP:0002586)1.54647055
130Hammertoe (HP:0001765)1.54360672
131Obstructive sleep apnea (HP:0002870)1.53782641
132Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.53621173
133Broad toe (HP:0001837)1.53464304
134Patellar dislocation (HP:0002999)1.53315574
135Skull defect (HP:0001362)1.53047123
136Shawl scrotum (HP:0000049)1.52824592
137Broad palm (HP:0001169)1.52627340
138Segmental peripheral demyelination/remyelination (HP:0003481)1.51983624
139Loss of speech (HP:0002371)1.51569687
140Broad phalanges of the hand (HP:0009768)1.51565632
141Hypoplasia of the iris (HP:0007676)1.51397218
142Hypercortisolism (HP:0001578)1.50981445
143Pulmonary artery stenosis (HP:0004415)1.50892370
144Joint laxity (HP:0001388)1.50849442
145Exotropia (HP:0000577)1.50138059
146Cellulitis (HP:0100658)1.49948009
147Tibial bowing (HP:0002982)1.49394392
148Abnormal cortical bone morphology (HP:0003103)1.49165161
149Increased IgE level (HP:0003212)1.49141336
150Laryngomalacia (HP:0001601)1.48955682
151Camptodactyly of toe (HP:0001836)1.48803478
152Abnormality of the sella turcica (HP:0002679)1.48776843
153Supernumerary ribs (HP:0005815)1.48224073
154Action tremor (HP:0002345)1.48139407
155Abnormality of the radial head (HP:0003995)1.47177080
156Open mouth (HP:0000194)1.47153164
157Broad finger (HP:0001500)1.46920471
158Bicuspid aortic valve (HP:0001647)1.46233195

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.19422960
2CAMK1G2.93494250
3MAP3K102.91009026
4CDK122.68257681
5SIK22.61434254
6RIPK12.54007574
7PRPF4B2.51084493
8CAMK1D2.50533827
9EPHB22.42853991
10EEF2K2.20810440
11SIK12.19537902
12DMPK2.03218423
13ICK1.96078489
14PTK61.89763012
15PDGFRA1.86575879
16FGFR21.79282966
17TAOK21.76470622
18PKN21.75009351
19TGFBR21.73073141
20SIK31.72015050
21BRD41.64774648
22EPHB11.59731456
23NTRK11.56465165
24MARK11.49096138
25ERBB31.44336068
26LATS21.44139668
27ERN11.43492689
28TTN1.42124817
29FGFR31.37811122
30DDR21.36491616
31IRAK31.36063185
32CASK1.29989949
33PRKD31.25246986
34MTOR1.22675890
35LATS11.22054437
36AKT31.21853790
37TNIK1.18908052
38ERBB21.16136668
39MAP4K11.15512374
40PDGFRB1.13133468
41MAP3K141.10323606
42NTRK21.09125489
43CHUK1.09123600
44KIT1.04128814
45PAK41.03110305
46PRKD21.02866615
47RPS6KA21.02508051
48TYRO30.97106513
49MATK0.96906554
50SGK4940.96741861
51SGK2230.96741861
52FGFR10.95157865
53NTRK30.93331881
54NEK90.93256172
55CSF1R0.92059548
56KSR10.92020523
57CDK90.91879479
58MARK20.91813616
59CDK60.91213788
60PTK20.90199213
61FES0.89921654
62MAP3K60.88903617
63MAP3K70.88775525
64HCK0.88494072
65EPHA30.88055602
66SGK30.86225551
67MAP3K130.86087847
68PRKCH0.85586372
69MAPK70.85444299
70MOS0.85436308
71RIPK40.81547903
72HIPK20.78214032
73CAMK40.76899458
74TGFBR10.76040290
75UHMK10.75864876
76TAOK10.74459761
77FGFR40.74044721
78KSR20.72989815
79STK30.72193790
80JAK10.71696672
81BLK0.71263679
82BMX0.70992480
83DAPK20.70570303
84SMG10.70388940
85CDC42BPA0.68388553
86DYRK1B0.68073121
87RET0.65791565
88CLK10.65251253
89CAMKK10.64907633
90ALK0.64023020
91PRKD10.62817876
92PAK20.62712333
93MAPK120.61311328
94FYN0.59892513
95RPS6KA40.59373109
96YES10.58293672
97MAPK150.56712243
98ROCK20.55174086
99WNK10.55032139
100MAP3K10.54574844
101SGK20.53227438
102CDK50.52937215
103FGR0.52924754
104TBK10.52748418
105MAPK80.52198955
106CSNK1A1L0.51998532
107IRAK10.50231539
108MAP2K30.49178311
109MAPK40.49073199
110SRC0.48787733
111MAPK100.48743213
112PDPK10.47270704
113LRRK20.46561142
114MINK10.46400659
115BTK0.46031325
116ZAP700.44678530
117STK100.44022398
118ROCK10.43665654
119STK110.42719400
120RPS6KC10.40836316
121RPS6KL10.40836316
122JAK30.40619958
123PAK60.40108700
124RPS6KA60.39415784
125ITK0.39370475
126RPS6KA10.38763963
127CAMK10.38544508
128EGFR0.37472944
129MAPK90.37373299
130ABL10.36812903
131IRAK20.36159958
132MAPK130.36141365
133MAPKAPK20.35613663
134PNCK0.34053234
135CSK0.32954016
136FER0.31624699

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052201.83317275
2Notch signaling pathway_Homo sapiens_hsa043301.77923177
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67039705
4Other glycan degradation_Homo sapiens_hsa005111.57925906
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56612969
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.52118943
7B cell receptor signaling pathway_Homo sapiens_hsa046621.48280698
8Osteoclast differentiation_Homo sapiens_hsa043801.46036159
9Adherens junction_Homo sapiens_hsa045201.44296635
10Colorectal cancer_Homo sapiens_hsa052101.43034563
11Viral myocarditis_Homo sapiens_hsa054161.42141942
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41886254
13Endometrial cancer_Homo sapiens_hsa052131.39050931
14Neurotrophin signaling pathway_Homo sapiens_hsa047221.38339872
15Basal cell carcinoma_Homo sapiens_hsa052171.36961438
16Proteoglycans in cancer_Homo sapiens_hsa052051.36502871
17Glioma_Homo sapiens_hsa052141.31954723
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31727539
19Leishmaniasis_Homo sapiens_hsa051401.29030568
20MicroRNAs in cancer_Homo sapiens_hsa052061.28692308
21Pancreatic cancer_Homo sapiens_hsa052121.26152850
22Cocaine addiction_Homo sapiens_hsa050301.23967047
23Focal adhesion_Homo sapiens_hsa045101.23783311
24Axon guidance_Homo sapiens_hsa043601.23544162
25Thyroid hormone signaling pathway_Homo sapiens_hsa049191.23406993
26Type II diabetes mellitus_Homo sapiens_hsa049301.20076593
27Toxoplasmosis_Homo sapiens_hsa051451.17522558
28Long-term potentiation_Homo sapiens_hsa047201.16575668
29Renal cell carcinoma_Homo sapiens_hsa052111.16524619
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16426647
31Prion diseases_Homo sapiens_hsa050201.15416035
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11657174
33Non-small cell lung cancer_Homo sapiens_hsa052231.11155556
34Lysine degradation_Homo sapiens_hsa003101.10853691
35Acute myeloid leukemia_Homo sapiens_hsa052211.09465276
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.08186147
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07944487
38Dilated cardiomyopathy_Homo sapiens_hsa054141.06365291
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05770705
40mTOR signaling pathway_Homo sapiens_hsa041501.04675650
41Shigellosis_Homo sapiens_hsa051311.03946098
42Bladder cancer_Homo sapiens_hsa052191.03642512
43Small cell lung cancer_Homo sapiens_hsa052221.02400546
44Chemokine signaling pathway_Homo sapiens_hsa040621.00985316
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00653975
46Hedgehog signaling pathway_Homo sapiens_hsa043400.99798068
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98816802
48VEGF signaling pathway_Homo sapiens_hsa043700.98508564
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98341348
50Prostate cancer_Homo sapiens_hsa052150.97112120
51Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96701182
52ErbB signaling pathway_Homo sapiens_hsa040120.96069557
53Platelet activation_Homo sapiens_hsa046110.95933314
54ECM-receptor interaction_Homo sapiens_hsa045120.95413433
55Rap1 signaling pathway_Homo sapiens_hsa040150.95252380
56TNF signaling pathway_Homo sapiens_hsa046680.94831267
57Hepatitis B_Homo sapiens_hsa051610.94536456
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94475362
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94457037
60T cell receptor signaling pathway_Homo sapiens_hsa046600.94244062
61Hippo signaling pathway_Homo sapiens_hsa043900.93416962
62Dorso-ventral axis formation_Homo sapiens_hsa043200.93097284
63Estrogen signaling pathway_Homo sapiens_hsa049150.92826121
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92276671
65Tuberculosis_Homo sapiens_hsa051520.91971720
66Amoebiasis_Homo sapiens_hsa051460.91776438
67Prolactin signaling pathway_Homo sapiens_hsa049170.90997171
68Salmonella infection_Homo sapiens_hsa051320.90610284
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88998357
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88960246
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88578080
72Glutamatergic synapse_Homo sapiens_hsa047240.88484523
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88320321
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88119438
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87949033
76Wnt signaling pathway_Homo sapiens_hsa043100.87621728
77Pathways in cancer_Homo sapiens_hsa052000.86518338
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.86091663
79Olfactory transduction_Homo sapiens_hsa047400.85127642
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84712338
81Long-term depression_Homo sapiens_hsa047300.82921095
82FoxO signaling pathway_Homo sapiens_hsa040680.82478330
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.81699808
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80754572
85MAPK signaling pathway_Homo sapiens_hsa040100.80360299
86HTLV-I infection_Homo sapiens_hsa051660.79927753
87Renin secretion_Homo sapiens_hsa049240.79708242
88Amphetamine addiction_Homo sapiens_hsa050310.79695080
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79479802
90Insulin resistance_Homo sapiens_hsa049310.79394614
91Endocytosis_Homo sapiens_hsa041440.79355316
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.79061557
93Measles_Homo sapiens_hsa051620.79016854
94GnRH signaling pathway_Homo sapiens_hsa049120.78446718
95Dopaminergic synapse_Homo sapiens_hsa047280.77718158
96Oxytocin signaling pathway_Homo sapiens_hsa049210.77614267
97Choline metabolism in cancer_Homo sapiens_hsa052310.76801218
98Cholinergic synapse_Homo sapiens_hsa047250.76389896
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.75819342
100Melanogenesis_Homo sapiens_hsa049160.75805554
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75173854
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75042006
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74410471
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73490350
105Apoptosis_Homo sapiens_hsa042100.73440070
106Malaria_Homo sapiens_hsa051440.72854643
107Insulin signaling pathway_Homo sapiens_hsa049100.72574231
108Melanoma_Homo sapiens_hsa052180.72463893
109Influenza A_Homo sapiens_hsa051640.72432682
110Lysosome_Homo sapiens_hsa041420.71899015
111Insulin secretion_Homo sapiens_hsa049110.71524101
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.71138126
113Ras signaling pathway_Homo sapiens_hsa040140.71137983
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.70601301
115Pertussis_Homo sapiens_hsa051330.70046064
116Gap junction_Homo sapiens_hsa045400.70041258
117cAMP signaling pathway_Homo sapiens_hsa040240.69650787
118TGF-beta signaling pathway_Homo sapiens_hsa043500.69474946
119Gastric acid secretion_Homo sapiens_hsa049710.68286475
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67674485
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66320760
122Hepatitis C_Homo sapiens_hsa051600.66288688
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65331128
124Nicotine addiction_Homo sapiens_hsa050330.65234340
125Circadian entrainment_Homo sapiens_hsa047130.65176650
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64915347
127Synaptic vesicle cycle_Homo sapiens_hsa047210.63944856
128AMPK signaling pathway_Homo sapiens_hsa041520.63483602

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