ZMIZ2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.82984215
2locomotory exploration behavior (GO:0035641)5.78320559
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.08631145
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.78078319
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.74287278
6layer formation in cerebral cortex (GO:0021819)4.69089027
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.50815620
8vocalization behavior (GO:0071625)4.33190043
9synaptic vesicle exocytosis (GO:0016079)4.30899704
10negative regulation of erythrocyte differentiation (GO:0045647)4.25169699
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.24078942
12regulation of synaptic vesicle exocytosis (GO:2000300)4.21970166
13regulation of glutamate receptor signaling pathway (GO:1900449)4.19420137
14G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.16922087
15regulation of ARF protein signal transduction (GO:0032012)4.12001057
16regulation of synapse structural plasticity (GO:0051823)4.09496151
17glutamate secretion (GO:0014047)4.09389461
18exploration behavior (GO:0035640)4.07264326
19sodium ion export (GO:0071436)4.01875192
20mannose metabolic process (GO:0006013)4.01109309
21negative regulation of cell killing (GO:0031342)3.90355726
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.90355726
23positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.76389767
24regulation of synaptic vesicle transport (GO:1902803)3.70794045
25dendritic spine morphogenesis (GO:0060997)3.69659523
26regulation of neuronal synaptic plasticity (GO:0048168)3.58265670
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.56913549
28regulation of ARF GTPase activity (GO:0032312)3.54703612
29protein localization to synapse (GO:0035418)3.53703278
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.51257111
31NIK/NF-kappaB signaling (GO:0038061)3.51168560
32neurotransmitter secretion (GO:0007269)3.49010533
33proline transport (GO:0015824)3.45460956
34activation of protein kinase A activity (GO:0034199)3.41411343
35positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.41306484
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.40026047
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36394722
38regulation of NFAT protein import into nucleus (GO:0051532)3.32699920
39activation of Rac GTPase activity (GO:0032863)3.28945428
40semaphorin-plexin signaling pathway (GO:0071526)3.27291958
41cytoskeletal anchoring at plasma membrane (GO:0007016)3.25067698
42response to muramyl dipeptide (GO:0032495)3.21162583
43negative regulation of microtubule polymerization (GO:0031115)3.19607570
44neuromuscular process controlling balance (GO:0050885)3.14621653
45positive regulation of histone deacetylation (GO:0031065)3.13263974
46cell migration in hindbrain (GO:0021535)3.12863416
47cellular potassium ion homeostasis (GO:0030007)3.09948516
48positive regulation of synapse maturation (GO:0090129)3.09608584
49positive regulation of Cdc42 GTPase activity (GO:0043089)3.07843191
50positive regulation of membrane potential (GO:0045838)3.06388415
51germinal center formation (GO:0002467)3.06022731
52long-term memory (GO:0007616)3.05701520
53auditory behavior (GO:0031223)3.04549234
54positive regulation of Rap GTPase activity (GO:0032854)3.04466974
55endothelial cell chemotaxis (GO:0035767)3.03760908
56activation of MAPKKK activity (GO:0000185)3.01896512
57cerebellar Purkinje cell differentiation (GO:0021702)3.01551097
58regulation of dendritic spine morphogenesis (GO:0061001)2.96700835
59prepulse inhibition (GO:0060134)2.94613965
60peptidyl-tyrosine autophosphorylation (GO:0038083)2.93249019
61dendrite morphogenesis (GO:0048813)2.93195046
62synaptic vesicle endocytosis (GO:0048488)2.93094630
63clathrin coat assembly (GO:0048268)2.92317190
64regulation of Rap GTPase activity (GO:0032317)2.91095141
65regulation of clathrin-mediated endocytosis (GO:2000369)2.90302203
66synaptic transmission, glutamatergic (GO:0035249)2.88284342
67cerebellar Purkinje cell layer development (GO:0021680)2.84685334
68regulation of type I interferon-mediated signaling pathway (GO:0060338)2.84179897
69neuron cell-cell adhesion (GO:0007158)2.83743893
70regulation of excitatory postsynaptic membrane potential (GO:0060079)2.82943483
71CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.82491845
72modulation by symbiont of host cellular process (GO:0044068)2.80036216
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.79401027
74cell communication by electrical coupling (GO:0010644)2.79365962
75regulation of T-helper 2 cell differentiation (GO:0045628)2.78220062
76glycine transport (GO:0015816)2.78187293
77gamma-aminobutyric acid transport (GO:0015812)2.77812195
78regulation of synaptic plasticity (GO:0048167)2.77577499
79thymic T cell selection (GO:0045061)2.76919948
80cell-cell junction maintenance (GO:0045217)2.76754101
81protein localization to endosome (GO:0036010)2.76459133
82activation of JUN kinase activity (GO:0007257)2.76110416
83nerve growth factor signaling pathway (GO:0038180)2.74873896
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.73448258
85glutamate receptor signaling pathway (GO:0007215)2.72114010
86regulation of histone H3-K27 methylation (GO:0061085)2.71936908
87regulation of gamma-delta T cell activation (GO:0046643)2.71285765
88signal complex assembly (GO:0007172)2.70959719
89regulation of early endosome to late endosome transport (GO:2000641)2.70901664
90negative thymic T cell selection (GO:0045060)2.68045613
91regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.68021352
92regulation of dendritic cell antigen processing and presentation (GO:0002604)2.67970508
93positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.67232149
94peptidyl-threonine phosphorylation (GO:0018107)2.66595401
95dopamine receptor signaling pathway (GO:0007212)2.66588909
96response to auditory stimulus (GO:0010996)2.66494459
97detection of bacterium (GO:0016045)2.65909433
98neuronal action potential propagation (GO:0019227)2.65314644
99adherens junction assembly (GO:0034333)2.65045576
100positive thymic T cell selection (GO:0045059)2.62432416
101histone H3-K36 demethylation (GO:0070544)2.62117968
102macrophage activation involved in immune response (GO:0002281)2.61726655
103vesicle transport along microtubule (GO:0047496)2.61363202
104response to type I interferon (GO:0034340)2.61176179
105modulation by virus of host process (GO:0019054)2.61109321
106regulation of glucose import in response to insulin stimulus (GO:2001273)2.60972973
107neurotransmitter-gated ion channel clustering (GO:0072578)2.60872609
108positive regulation of synaptic transmission, GABAergic (GO:0032230)2.60179442
109regulation of postsynaptic membrane potential (GO:0060078)2.59550209
110negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.59456981
111negative regulation of cell size (GO:0045792)2.59416935
112stress fiber assembly (GO:0043149)2.59250595
113positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.59130678
114pre-miRNA processing (GO:0031054)2.58845036
115glial cell proliferation (GO:0014009)2.58489960
116focal adhesion assembly (GO:0048041)2.57254611
117cell-substrate adherens junction assembly (GO:0007045)2.57254611
118cellular response to virus (GO:0098586)2.57129964
119positive regulation of fibroblast migration (GO:0010763)2.56558168
120apoptotic process involved in morphogenesis (GO:0060561)2.56212356
121positive regulation by symbiont of host defense response (GO:0052509)2.53606631
122modulation by symbiont of host defense response (GO:0052031)2.53606631
123modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.53606631
124modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.53606631
125positive regulation by organism of defense response of other organism involved in symbiotic interact2.53606631
126modulation by symbiont of host immune response (GO:0052553)2.53606631
127negative regulation of myotube differentiation (GO:0010832)2.53606017
128cellular response to type I interferon (GO:0071357)2.53552181
129type I interferon signaling pathway (GO:0060337)2.53552181
130T cell selection (GO:0045058)2.53532030
131antigen processing and presentation of endogenous antigen (GO:0019883)2.53092096
132negative T cell selection (GO:0043383)2.53044897
133neurotransmitter transport (GO:0006836)2.52812733
134neuron recognition (GO:0008038)2.51705509
135positive regulation of protein dephosphorylation (GO:0035307)2.51563961
136positive regulation of CREB transcription factor activity (GO:0032793)2.51244875
137regulation of neurotransmitter secretion (GO:0046928)2.49644258
138detection of other organism (GO:0098543)2.49142417
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.48763830
140peptidyl-threonine modification (GO:0018210)2.48001482
141cellular response to nerve growth factor stimulus (GO:1990090)2.47742762
142response to nerve growth factor (GO:1990089)2.47742762
143membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.47535084
144regulation of extracellular matrix disassembly (GO:0010715)2.46378422
145response to laminar fluid shear stress (GO:0034616)2.46071717
146neuron-neuron synaptic transmission (GO:0007270)2.45737477
147intracellular estrogen receptor signaling pathway (GO:0030520)2.45551177
148regulation of dendritic spine development (GO:0060998)2.45497574
149positive regulation of gamma-delta T cell activation (GO:0046645)2.45484680
150cerebellum development (GO:0021549)2.45125312
151adenosine receptor signaling pathway (GO:0001973)2.45015973
152positive regulation of type 2 immune response (GO:0002830)2.44890785
153membrane depolarization during action potential (GO:0086010)2.44512991
154positive regulation of protein deacetylation (GO:0090312)2.44289225
155positive regulation of neurotransmitter secretion (GO:0001956)2.43925983
156neuronal ion channel clustering (GO:0045161)2.42971961
157establishment of nucleus localization (GO:0040023)2.42470137
158intraspecies interaction between organisms (GO:0051703)2.42444807
159social behavior (GO:0035176)2.42444807
160positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.42048090
161cell volume homeostasis (GO:0006884)2.39508148
162B cell receptor signaling pathway (GO:0050853)2.39277771
163regulation of gamma-delta T cell differentiation (GO:0045586)2.38454247
164response to peptidoglycan (GO:0032494)2.38055979
165negative regulation of viral release from host cell (GO:1902187)2.35041570
166negative regulation of toll-like receptor signaling pathway (GO:0034122)2.33143142
167regulation of lipid kinase activity (GO:0043550)2.31498659
168barbed-end actin filament capping (GO:0051016)2.30829359
169interferon-gamma-mediated signaling pathway (GO:0060333)2.29083129
170positive regulation of Rac GTPase activity (GO:0032855)2.27570088
171regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.25601669
172histone H4 deacetylation (GO:0070933)2.23446938
173positive regulation of receptor recycling (GO:0001921)2.23122228
174lipopolysaccharide-mediated signaling pathway (GO:0031663)2.20975747
175regulation of necroptotic process (GO:0060544)2.19867856
176planar cell polarity pathway involved in neural tube closure (GO:0090179)2.19449392
177regulation of interferon-beta biosynthetic process (GO:0045357)2.16231376
178regulation of leukocyte degranulation (GO:0043300)2.15096258
179regulation of type 2 immune response (GO:0002828)2.13896024

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.29482258
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.47475733
3MYC_22102868_ChIP-Seq_BL_Human3.15969042
4* RARB_27405468_Chip-Seq_BRAIN_Mouse2.92091949
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.84592604
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.83860958
7KDM2B_26808549_Chip-Seq_DND41_Human2.74442816
8DROSHA_22980978_ChIP-Seq_HELA_Human2.57874181
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.53088069
10KDM2B_26808549_Chip-Seq_K562_Human2.34403191
11* TCF7_22412390_ChIP-Seq_EML_Mouse2.33718445
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.30006976
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25666102
14LXR_22292898_ChIP-Seq_THP-1_Human2.24314427
15KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.22730816
16REST_21632747_ChIP-Seq_MESCs_Mouse2.20766736
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.20401987
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18215417
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.16943673
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.16930710
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14135683
22VDR_21846776_ChIP-Seq_THP-1_Human2.09084467
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.06760748
24ZFP281_27345836_Chip-Seq_ESCs_Mouse2.05220879
25* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human2.00176874
26KDM2B_26808549_Chip-Seq_JURKAT_Human1.98359640
27* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.95985208
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92821885
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.92766810
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91952771
31GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.91298214
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.90240873
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.88907174
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79616507
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.79094782
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73482218
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69837979
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66310021
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65477131
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61773397
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58129516
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58129516
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57576298
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.57384258
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57350186
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.56611587
47DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.56607967
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.55081387
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.51045970
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.50778966
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.48721088
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.46836410
53SPI1_23127762_ChIP-Seq_K562_Human1.46788356
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45525718
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44372116
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42798267
57MAF_26560356_Chip-Seq_TH1_Human1.41775145
58* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40686210
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.37807323
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.37395940
61UTX_26944678_Chip-Seq_JUKART_Human1.37389169
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37175823
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36909494
64* SMC4_20622854_ChIP-Seq_HELA_Human1.35801458
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35256518
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34954319
67TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.34855756
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.32512950
69CREB1_26743006_Chip-Seq_LNCaP_Human1.31312645
70* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30662944
71ZNF263_19887448_ChIP-Seq_K562_Human1.29402676
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28982700
73P68_20966046_ChIP-Seq_HELA_Human1.28134115
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25844582
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25297422
76VDR_24763502_ChIP-Seq_THP-1_Human1.24179860
77MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21560744
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21300090
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20410923
80* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18701611
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18245753
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17485379
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17259430
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17121011
85FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16715454
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16533394
87CTCF_27219007_Chip-Seq_Bcells_Human1.15837219
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14615874
89SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13800406
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13519091
91* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12155243
92NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11438801
93RACK7_27058665_Chip-Seq_MCF-7_Human1.11001619
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.10882883
95RING1B_27294783_Chip-Seq_ESCs_Mouse1.10871333
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10841423
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10444698
98OCT4_19829295_ChIP-Seq_ESCs_Human1.10121181
99ELF1_20517297_ChIP-Seq_JURKAT_Human1.09468377
100CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09215327
101ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08696994
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08565597
103MAF_26560356_Chip-Seq_TH2_Human1.08453545
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05730192
105NCOR1_26117541_ChIP-Seq_K562_Human1.05508118
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.04280354
107TET1_21490601_ChIP-Seq_MESCs_Mouse1.04099989
108RUNX_20019798_ChIP-Seq_JUKART_Human1.03904558
109TP53_22127205_ChIP-Seq_IMR90_Human1.03814939
110UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02695714
111* SA1_27219007_Chip-Seq_ERYTHROID_Human1.02303746
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02066072
113GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00194874
114SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99415102
115MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99168735
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99062846
117* RING1B_27294783_Chip-Seq_NPCs_Mouse0.98764089
118KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97306894
119* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95017658
120SCL_19346495_ChIP-Seq_HPC-7_Human0.94736117
121PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94025322
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93749455
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92963125
124* BCOR_27268052_Chip-Seq_Bcells_Human0.92561632
125SA1_27219007_Chip-Seq_Bcells_Human0.92026037
126SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91362515
127JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91322967
128PHF8_20622854_ChIP-Seq_HELA_Human0.90942718
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89349877
130BCL6_27268052_Chip-Seq_Bcells_Human0.87879643
131PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87783645
132* RUNX1_27514584_Chip-Seq_MCF-7_Human0.86742918
133ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86592276
134CTCF_21964334_ChIP-Seq_BJAB-B_Human0.86514094
135TP63_22573176_ChIP-Seq_HFKS_Human0.86445352
136* DPY_21335234_ChIP-Seq_ESCs_Mouse0.85979631

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.74203224
2MP0003635_abnormal_synaptic_transmissio3.58862593
3MP0003705_abnormal_hypodermis_morpholog3.40282443
4MP0004270_analgesia3.11203065
5MP0003436_decreased_susceptibility_to2.96174832
6MP0003303_peritoneal_inflammation2.90211280
7MP0005423_abnormal_somatic_nervous2.86715408
8MP0002063_abnormal_learning/memory/cond2.85984210
9MP0003880_abnormal_central_pattern2.71853071
10MP0008961_abnormal_basal_metabolism2.66369753
11MP0009745_abnormal_behavioral_response2.56454390
12MP0004510_myositis2.50278983
13MP0002064_seizures2.50093139
14MP0005058_abnormal_lysosome_morphology2.47580027
15MP0002822_catalepsy2.46596934
16MP0004858_abnormal_nervous_system2.35655559
17MP0000569_abnormal_digit_pigmentation2.32371783
18MP0008569_lethality_at_weaning2.21286501
19MP0002909_abnormal_adrenal_gland2.20546790
20MP0005451_abnormal_body_composition2.17664142
21MP0002572_abnormal_emotion/affect_behav2.13781214
22MP0009046_muscle_twitch2.08394852
23MP0004947_skin_inflammation2.03083473
24MP0003091_abnormal_cell_migration1.97367850
25MP0004811_abnormal_neuron_physiology1.92901102
26MP0005409_darkened_coat_color1.87332230
27MP0001968_abnormal_touch/_nociception1.85782888
28MP0008260_abnormal_autophagy1.81639422
29MP0003453_abnormal_keratinocyte_physiol1.79674608
30MP0003329_amyloid_beta_deposits1.77185874
31MP0002734_abnormal_mechanical_nocicepti1.70918480
32MP0005025_abnormal_response_to1.68694086
33MP0001486_abnormal_startle_reflex1.66603800
34MP0002733_abnormal_thermal_nociception1.66541925
35MP0003300_gastrointestinal_ulcer1.64553165
36MP0000678_abnormal_parathyroid_gland1.60317240
37MP0009840_abnormal_foam_cell1.59780866
38MP0000778_abnormal_nervous_system1.53761400
39MP0002272_abnormal_nervous_system1.53473884
40MP0010155_abnormal_intestine_physiology1.52921436
41MP0002249_abnormal_larynx_morphology1.50325590
42MP0001501_abnormal_sleep_pattern1.50188047
43MP0003787_abnormal_imprinting1.49470818
44MP0003879_abnormal_hair_cell1.48879535
45MP0004885_abnormal_endolymph1.48295104
46MP0002419_abnormal_innate_immunity1.47152178
47MP0001348_abnormal_lacrimal_gland1.45458844
48MP0001970_abnormal_pain_threshold1.45190077
49MP0001440_abnormal_grooming_behavior1.45075930
50MP0005076_abnormal_cell_differentiation1.43900396
51MP0002184_abnormal_innervation1.42592148
52MP0002998_abnormal_bone_remodeling1.42224075
53MP0003566_abnormal_cell_adhesion1.40730394
54MP0009780_abnormal_chondrocyte_physiolo1.40200484
55MP0003279_aneurysm1.38598359
56MP0003172_abnormal_lysosome_physiology1.37607083
57MP0003191_abnormal_cellular_cholesterol1.35610267
58MP0000955_abnormal_spinal_cord1.34911530
59MP0005666_abnormal_adipose_tissue1.32872153
60MP0002557_abnormal_social/conspecific_i1.32003050
61MP0001533_abnormal_skeleton_physiology1.30067731
62MP0009333_abnormal_splenocyte_physiolog1.28966551
63MP0002735_abnormal_chemical_nociception1.28769939
64MP0003690_abnormal_glial_cell1.28311766
65MP0002067_abnormal_sensory_capabilities1.28286874
66MP0002933_joint_inflammation1.26011814
67MP0003866_abnormal_defecation1.24212090
68MP0005670_abnormal_white_adipose1.23342934
69MP0000858_altered_metastatic_potential1.22338339
70MP0005310_abnormal_salivary_gland1.21105673
71MP0005387_immune_system_phenotype1.20408945
72MP0001790_abnormal_immune_system1.20408945
73MP0004185_abnormal_adipocyte_glucose1.20396460
74MP0005386_behavior/neurological_phenoty1.19892301
75MP0004924_abnormal_behavior1.19892301
76MP0001835_abnormal_antigen_presentation1.17429009
77MP0002736_abnormal_nociception_after1.17142005
78MP0002066_abnormal_motor_capabilities/c1.14573642
79MP0008874_decreased_physiological_sensi1.14112536
80MP0001800_abnormal_humoral_immune1.12878284
81MP0005375_adipose_tissue_phenotype1.12734438
82MP0000685_abnormal_immune_system1.12000585
83MP0002882_abnormal_neuron_morphology1.09665914
84MP0005645_abnormal_hypothalamus_physiol1.09130993
85MP0002405_respiratory_system_inflammati1.08251274
86MP0010234_abnormal_vibrissa_follicle1.07972841
87MP0005499_abnormal_olfactory_system1.07945645
88MP0005394_taste/olfaction_phenotype1.07945645
89MP0002152_abnormal_brain_morphology1.07128993
90MP0003075_altered_response_to1.06822906
91MP0002653_abnormal_ependyma_morphology1.06795630
92MP0002138_abnormal_hepatobiliary_system1.04787559
93MP0003763_abnormal_thymus_physiology1.03439723
94MP0000751_myopathy1.02731751
95MP0002148_abnormal_hypersensitivity_rea1.01937140
96MP0009785_altered_susceptibility_to1.00617148
97MP0000604_amyloidosis1.00274979
98MP0003633_abnormal_nervous_system1.00045928
99MP0004381_abnormal_hair_follicle0.99428949
100MP0002796_impaired_skin_barrier0.99067117
101MP0002398_abnormal_bone_marrow0.98145744
102MP0000733_abnormal_muscle_development0.96831760
103MP0005166_decreased_susceptibility_to0.95176535
104MP0006082_CNS_inflammation0.93468545
105MP0001958_emphysema0.92019162
106MP0002429_abnormal_blood_cell0.90267327
107MP0000003_abnormal_adipose_tissue0.89517993
108MP0003724_increased_susceptibility_to0.89104776
109MP0001873_stomach_inflammation0.88747154
110MP0003183_abnormal_peptide_metabolism0.88662966
111MP0002069_abnormal_eating/drinking_beha0.87388607
112MP0000703_abnormal_thymus_morphology0.86223729
113MP0004808_abnormal_hematopoietic_stem0.86190107
114MP0001845_abnormal_inflammatory_respons0.85658802
115MP0005397_hematopoietic_system_phenotyp0.85250358
116MP0001545_abnormal_hematopoietic_system0.85250358
117MP0002877_abnormal_melanocyte_morpholog0.84432087
118MP0005464_abnormal_platelet_physiology0.83257107
119MP0008872_abnormal_physiological_respon0.81696302
120MP0002420_abnormal_adaptive_immunity0.80968174
121MP0001853_heart_inflammation0.80680115
122MP0003631_nervous_system_phenotype0.80234374
123MP0005023_abnormal_wound_healing0.80123431
124MP0001819_abnormal_immune_cell0.79986137
125MP0005000_abnormal_immune_tolerance0.79733317
126MP0003123_paternal_imprinting0.79641812
127MP0005390_skeleton_phenotype0.78663091
128MP0009278_abnormal_bone_marrow0.78180233
129MP0002452_abnormal_antigen_presenting0.77744312
130MP0004130_abnormal_muscle_cell0.77736953
131MP0001502_abnormal_circadian_rhythm0.77465445
132MP0000920_abnormal_myelination0.76890457
133MP0001851_eye_inflammation0.76330601
134MP0005621_abnormal_cell_physiology0.75478028
135MP0000767_abnormal_smooth_muscle0.75021751
136MP0002723_abnormal_immune_serum0.74805448
137MP0008770_decreased_survivor_rate0.74673668
138MP0000716_abnormal_immune_system0.74503379
139MP0004264_abnormal_extraembryonic_tissu0.74443637
140MP0008004_abnormal_stomach_pH0.74230480
141MP0005671_abnormal_response_to0.72971893
142MP0003861_abnormal_nervous_system0.72724123
143MP0005174_abnormal_tail_pigmentation0.70169198
144MP0010352_gastrointestinal_tract_polyps0.69819807
145MP0003646_muscle_fatigue0.63612311
146MP0010769_abnormal_survival0.63170018
147MP0003045_fibrosis0.62975783
148MP0002234_abnormal_pharynx_morphology0.60026547
149MP0010768_mortality/aging0.59372475
150MP0002089_abnormal_postnatal_growth/wei0.57854425
151MP0001849_ear_inflammation0.57329286
152MP0005535_abnormal_body_temperature0.57128364
153MP0002722_abnormal_immune_system0.56799156
154MP0002083_premature_death0.56402509
155MP0003634_abnormal_glial_cell0.54890326
156MP0003283_abnormal_digestive_organ0.54701787
157MP0010770_preweaning_lethality0.53472235

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.79415345
2Visual hallucinations (HP:0002367)4.06472155
3Supranuclear gaze palsy (HP:0000605)3.69839508
4Focal seizures (HP:0007359)3.67470778
5Focal motor seizures (HP:0011153)3.66123145
6Papilledema (HP:0001085)3.63124861
7Hyperacusis (HP:0010780)3.59645528
8Abnormality of the lower motor neuron (HP:0002366)3.53397301
9Broad face (HP:0000283)3.39864982
10Dysmetric saccades (HP:0000641)3.17223680
11Insomnia (HP:0100785)3.01011105
12Cerebral aneurysm (HP:0004944)3.00485332
13Ankle clonus (HP:0011448)2.89293992
14Gastrointestinal stroma tumor (HP:0100723)2.84993127
15Urinary bladder sphincter dysfunction (HP:0002839)2.82927796
16Abnormal social behavior (HP:0012433)2.81360637
17Impaired social interactions (HP:0000735)2.81360637
18Poor eye contact (HP:0000817)2.81225199
19Pointed chin (HP:0000307)2.80596333
20Amyotrophic lateral sclerosis (HP:0007354)2.80265216
21Urinary urgency (HP:0000012)2.77888942
22Thin bony cortex (HP:0002753)2.76842184
23Genetic anticipation (HP:0003743)2.74597214
24Annular pancreas (HP:0001734)2.72038032
25Emphysema (HP:0002097)2.69765654
26Obstructive sleep apnea (HP:0002870)2.68833425
27Abnormality of binocular vision (HP:0011514)2.65571101
28Diplopia (HP:0000651)2.65571101
29Apathy (HP:0000741)2.64887768
30Eczematoid dermatitis (HP:0000976)2.64086702
31Mutism (HP:0002300)2.62667035
32Depression (HP:0000716)2.61580303
33Progressive cerebellar ataxia (HP:0002073)2.61564883
34Action tremor (HP:0002345)2.59808142
35Neurofibrillary tangles (HP:0002185)2.57257930
36Impaired smooth pursuit (HP:0007772)2.53530409
37Distal lower limb amyotrophy (HP:0008944)2.53309572
38Impaired vibration sensation in the lower limbs (HP:0002166)2.51698742
39Postural instability (HP:0002172)2.51592583
40Macroorchidism (HP:0000053)2.45951855
41Hemiplegia (HP:0002301)2.44835560
42Stereotypic behavior (HP:0000733)2.43904034
43Elfin facies (HP:0004428)2.42379845
44Diminished motivation (HP:0000745)2.41082493
45Epileptic encephalopathy (HP:0200134)2.38318344
46Ventricular fibrillation (HP:0001663)2.26886423
47Abnormality of ocular smooth pursuit (HP:0000617)2.26361510
48Dysostosis multiplex (HP:0000943)2.20119489
49Flat acetabular roof (HP:0003180)2.19878552
50Truncal ataxia (HP:0002078)2.18883308
51Absence seizures (HP:0002121)2.14346488
52Broad-based gait (HP:0002136)2.13180730
53Overriding aorta (HP:0002623)2.12516640
54Abnormality of the nasal mucosa (HP:0000433)2.11665912
55Nuclear cataract (HP:0100018)2.10704702
56Neoplasm of the heart (HP:0100544)2.09857131
57Spastic gait (HP:0002064)2.07346607
58J-shaped sella turcica (HP:0002680)2.07299458
59Lower limb amyotrophy (HP:0007210)2.07158540
60Long palpebral fissure (HP:0000637)2.06278803
61Shallow orbits (HP:0000586)2.04906756
62Hemorrhage of the eye (HP:0011885)2.03990736
63Gingivitis (HP:0000230)2.03809018
64Cerebral inclusion bodies (HP:0100314)2.03047320
65Rapidly progressive (HP:0003678)2.01794140
66Nasal polyposis (HP:0100582)2.01709508
67Febrile seizures (HP:0002373)2.01333401
68Heterotopia (HP:0002282)2.01021003
69Polygenic inheritance (HP:0010982)2.00730480
70Bundle branch block (HP:0011710)2.00689685
71Papilloma (HP:0012740)2.00548990
72Verrucae (HP:0200043)2.00548990
73Metaphyseal cupping (HP:0003021)2.00548901
74Atonic seizures (HP:0010819)2.00446853
75Vertebral arch anomaly (HP:0008438)2.00432382
76Neuronal loss in central nervous system (HP:0002529)1.99963213
77Abnormality of the fingertips (HP:0001211)1.99537452
78Hypercortisolism (HP:0001578)1.98877117
79Abnormal eating behavior (HP:0100738)1.98247078
80Abnormality of the thoracic spine (HP:0100711)1.97941655
81Inappropriate behavior (HP:0000719)1.97129554
82Restrictive lung disease (HP:0002091)1.95939679
83Interstitial pulmonary disease (HP:0006530)1.95871793
84Bronchomalacia (HP:0002780)1.94345313
85Increased cerebral lipofuscin (HP:0011813)1.94293461
86Malnutrition (HP:0004395)1.94032365
87Hemiparesis (HP:0001269)1.93522702
88Ankyloglossia (HP:0010296)1.92606441
89Colitis (HP:0002583)1.92362120
90Cervical subluxation (HP:0003308)1.92295811
91Dysmetria (HP:0001310)1.92245679
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92173903
93Distal lower limb muscle weakness (HP:0009053)1.92155656
94Slow saccadic eye movements (HP:0000514)1.91855071
95Amblyopia (HP:0000646)1.91326944
96Dialeptic seizures (HP:0011146)1.90221562
97Agammaglobulinemia (HP:0004432)1.89692670
98Large eyes (HP:0001090)1.89591535
99Megalencephaly (HP:0001355)1.88678338
100Distal upper limb amyotrophy (HP:0007149)1.87619577
101Upper limb amyotrophy (HP:0009129)1.87619577
102Segmental peripheral demyelination/remyelination (HP:0003481)1.87445804
103Progressive inability to walk (HP:0002505)1.87427211
104Aneurysm (HP:0002617)1.86664267
105Insidious onset (HP:0003587)1.86136419
106Termporal pattern (HP:0011008)1.86136419
107Onion bulb formation (HP:0003383)1.86120698
108Deep palmar crease (HP:0006191)1.85897114
109Cellulitis (HP:0100658)1.85177377
110Intellectual disability, profound (HP:0002187)1.84497006
111Abnormality of macrophages (HP:0004311)1.83971375
112Generalized tonic-clonic seizures (HP:0002069)1.82918380
113Gastrointestinal inflammation (HP:0004386)1.82902573
114Thoracic kyphosis (HP:0002942)1.82633124
115Dysdiadochokinesis (HP:0002075)1.82481879
116Abnormality of the astrocytes (HP:0100707)1.82354092
117Astrocytoma (HP:0009592)1.82354092
118Axonal loss (HP:0003447)1.81664973
119Gaze-evoked nystagmus (HP:0000640)1.80835699
120Renovascular hypertension (HP:0100817)1.80793813
121Disproportionate tall stature (HP:0001519)1.80379745
122Mucopolysacchariduria (HP:0008155)1.79996020
123Urinary glycosaminoglycan excretion (HP:0003541)1.79996020
124Bradykinesia (HP:0002067)1.78847523
125Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.78649320
126Centrally nucleated skeletal muscle fibers (HP:0003687)1.78381394
127Chronic otitis media (HP:0000389)1.78009833
128Stridor (HP:0010307)1.77925840
129Systemic lupus erythematosus (HP:0002725)1.76707177
130Sacral dimple (HP:0000960)1.76128509
131Resting tremor (HP:0002322)1.75956114
132Recurrent bronchitis (HP:0002837)1.75770697
133Increased connective tissue (HP:0009025)1.75704627
134Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75580602
135Meningitis (HP:0001287)1.74732285
136Torticollis (HP:0000473)1.74121388
137Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73944807
138Abnormality of polysaccharide metabolism (HP:0011012)1.73944807
139Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73944807
140Easy fatigability (HP:0003388)1.73862276
141Mediastinal lymphadenopathy (HP:0100721)1.73657349
142Fatigue (HP:0012378)1.73490476
143Abnormal delayed hypersensitivity skin test (HP:0002963)1.73455257
144Turricephaly (HP:0000262)1.73087741
145Recurrent viral infections (HP:0004429)1.72054244
146Recurrent bacterial skin infections (HP:0005406)1.72002327
147Long eyelashes (HP:0000527)1.70834714
148Inflammation of the large intestine (HP:0002037)1.70763102
149Hyperparathyroidism (HP:0000843)1.70419153
150Frequent falls (HP:0002359)1.69743770
151Generalized hypotonia (HP:0001290)1.69628205
152Increased neuronal autofluorescent lipopigment (HP:0002074)1.68866068
153Recurrent abscess formation (HP:0002722)1.68419886
154Urethral obstruction (HP:0000796)1.68096250
155Mitral regurgitation (HP:0001653)1.68024640
156Increased IgE level (HP:0003212)1.67791803
157Intention tremor (HP:0002080)1.66826254
158Abnormality of saccadic eye movements (HP:0000570)1.66347383
159Protrusio acetabuli (HP:0003179)1.65259412
160Vasculitis (HP:0002633)1.65236943
161Achilles tendon contracture (HP:0001771)1.64372281
162Loss of speech (HP:0002371)1.60393248
163Precocious puberty (HP:0000826)1.59497017
164Hand muscle atrophy (HP:0009130)1.59201253
165Asymmetric septal hypertrophy (HP:0001670)1.58775056
166Dislocated radial head (HP:0003083)1.54316358
167Abnormality of the distal phalanx of the thumb (HP:0009617)1.53834577
168Atelectasis (HP:0100750)1.52176604
169Fragile skin (HP:0001030)1.51347115
170Chronic obstructive pulmonary disease (HP:0006510)1.51276514
171Obstructive lung disease (HP:0006536)1.51276514

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.75954135
2MARK13.02951349
3SIK23.01016000
4SIK13.00492445
5PRKD32.75331372
6TRIB32.70885709
7SMG12.62020422
8EEF2K2.49074163
9MAP4K12.39793016
10EPHA42.38867086
11TAOK12.22556640
12NTRK32.19845647
13DAPK22.16793596
14PAK62.00839958
15FGFR41.98627913
16ALK1.94751975
17RIPK41.89768073
18KSR21.89646141
19MAP3K101.87486416
20NTRK21.85373083
21IRAK31.84547588
22CAMKK11.80914434
23ICK1.78312422
24MINK11.72589670
25TYRO31.68308053
26PKN21.65718195
27MAP3K41.56710897
28FES1.43548735
29MST1R1.43365605
30EPHA21.40431137
31TYK21.39902407
32CDK121.38260128
33SIK31.33095426
34MAP3K131.25135185
35MAP3K141.25108868
36CDK51.24015259
37DDR21.23568437
38PRKCH1.23174567
39UHMK11.21356054
40MARK21.19218773
41TBK11.16336500
42STK111.15834757
43RIPK11.14687637
44DAPK11.14605982
45BLK1.13589642
46CAMK1G1.13324628
47STK381.12209941
48KSR11.10689719
49GRK61.09593816
50RET1.09041159
51PRPF4B1.07523878
52MAP3K111.07061482
53MAP3K71.05139007
54CDK191.00523277
55TESK10.99865118
56NTRK10.95479006
57TAOK20.90640264
58ZAP700.88750615
59MAP2K30.88361546
60SGK30.87779113
61SYK0.86316328
62IRAK40.85598114
63MAP2K40.85596215
64DMPK0.85394861
65SCYL20.85316734
66PDK10.84697727
67TTN0.83926714
68NME20.82970085
69TNK20.77993306
70PNCK0.77422920
71RPS6KA20.75370169
72MAP2K70.75176237
73HCK0.74156628
74CSK0.73650977
75MAP3K30.73259711
76CDC42BPA0.72991650
77MAPK120.71938248
78PHKG20.71842282
79PHKG10.71842282
80MAP3K60.71393817
81CHUK0.70694997
82MAP3K20.70671688
83MAPK150.70048534
84CAMK1D0.69546442
85ERN10.69489624
86IKBKE0.68922253
87BMX0.67941727
88CAMK10.67406037
89JAK10.67042966
90MAP3K10.66305093
91BTK0.65931692
92LRRK20.65410456
93MAPK110.64516255
94PTK60.63701816
95IRAK20.63417643
96RPS6KC10.62763070
97RPS6KL10.62763070
98CDK150.62122413
99MAPK70.61572122
100RAF10.61269571
101CDK180.58885415
102PRKD20.58539161
103CDK11A0.58031838
104CAMK40.57591890
105FGFR30.57021344
106PDPK10.56916460
107HIPK20.55215522
108MAPK130.55103052
109CDK40.54447787
110FYN0.53459908
111PRKCG0.50294234
112PTK20.49966134
113JAK20.49230837
114PRKCZ0.48404324
115GRK50.47791971
116JAK30.47358938
117CDK140.47138302
118RPS6KA60.45402163
119ARAF0.44661965
120LMTK20.43808634
121PAK40.42561502
122RPS6KA10.42185314
123SGK10.41351449
124MAPK80.41211813
125CSF1R0.40821301
126DYRK1A0.40211548
127MAP2K20.39892269
128RPS6KA30.39610155
129IKBKB0.39450737
130MAPK40.38729276
131LATS20.38027862
132FGR0.37989222
133DYRK1B0.37809164
134MTOR0.37569727
135MAP2K60.37455272
136PDGFRB0.37117457
137MAPK100.36813888
138PDGFRA0.36417121
139CSNK1G20.36376067
140NEK10.34700796
141EPHB10.34415148
142PRKD10.32500632
143SGK20.32323259
144SGK2230.31966231
145SGK4940.31966231

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.15329406
2Olfactory transduction_Homo sapiens_hsa047402.08410539
3Long-term potentiation_Homo sapiens_hsa047202.06980543
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05459083
5Other glycan degradation_Homo sapiens_hsa005111.99629845
6Circadian entrainment_Homo sapiens_hsa047131.83814622
7Glutamatergic synapse_Homo sapiens_hsa047241.76856469
8Nicotine addiction_Homo sapiens_hsa050331.72453222
9Morphine addiction_Homo sapiens_hsa050321.65728251
10B cell receptor signaling pathway_Homo sapiens_hsa046621.65324026
11Amphetamine addiction_Homo sapiens_hsa050311.60145332
12Dopaminergic synapse_Homo sapiens_hsa047281.60055369
13Gastric acid secretion_Homo sapiens_hsa049711.59361504
14Cholinergic synapse_Homo sapiens_hsa047251.56818440
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56761458
16GABAergic synapse_Homo sapiens_hsa047271.56520597
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49486975
18Salivary secretion_Homo sapiens_hsa049701.48412541
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47699812
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45652320
21Neurotrophin signaling pathway_Homo sapiens_hsa047221.44582249
22Glioma_Homo sapiens_hsa052141.43843542
23Type II diabetes mellitus_Homo sapiens_hsa049301.43327197
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42189402
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39490123
26Oxytocin signaling pathway_Homo sapiens_hsa049211.38503532
27VEGF signaling pathway_Homo sapiens_hsa043701.38372515
28Insulin secretion_Homo sapiens_hsa049111.34989809
29GnRH signaling pathway_Homo sapiens_hsa049121.32139688
30Estrogen signaling pathway_Homo sapiens_hsa049151.30136564
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29664209
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28947020
33Cocaine addiction_Homo sapiens_hsa050301.28064028
34Allograft rejection_Homo sapiens_hsa053301.27519633
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26943422
36Influenza A_Homo sapiens_hsa051641.25018594
37Non-small cell lung cancer_Homo sapiens_hsa052231.24439701
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.23600781
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22370656
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20321624
41ErbB signaling pathway_Homo sapiens_hsa040121.20226304
42T cell receptor signaling pathway_Homo sapiens_hsa046601.19970768
43mTOR signaling pathway_Homo sapiens_hsa041501.18977302
44Dorso-ventral axis formation_Homo sapiens_hsa043201.18626937
45Renin secretion_Homo sapiens_hsa049241.18586159
46Autoimmune thyroid disease_Homo sapiens_hsa053201.18352689
47TNF signaling pathway_Homo sapiens_hsa046681.16876722
48Hepatitis C_Homo sapiens_hsa051601.15639057
49Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15283278
50Long-term depression_Homo sapiens_hsa047301.14888976
51Endometrial cancer_Homo sapiens_hsa052131.13950200
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13423705
53Chronic myeloid leukemia_Homo sapiens_hsa052201.12180845
54Graft-versus-host disease_Homo sapiens_hsa053321.11398994
55Gap junction_Homo sapiens_hsa045401.11189901
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09196178
57Chemokine signaling pathway_Homo sapiens_hsa040621.08586279
58Intestinal immune network for IgA production_Homo sapiens_hsa046721.08074410
59Phospholipase D signaling pathway_Homo sapiens_hsa040721.06542071
60Prion diseases_Homo sapiens_hsa050201.06490095
61Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04823676
62cAMP signaling pathway_Homo sapiens_hsa040241.01357696
63Osteoclast differentiation_Homo sapiens_hsa043801.00354786
64Staphylococcus aureus infection_Homo sapiens_hsa051500.99839139
65Colorectal cancer_Homo sapiens_hsa052100.99469279
66MAPK signaling pathway_Homo sapiens_hsa040100.99009391
67Hepatitis B_Homo sapiens_hsa051610.98615325
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97061697
69Calcium signaling pathway_Homo sapiens_hsa040200.96417294
70Bladder cancer_Homo sapiens_hsa052190.96210233
71Acute myeloid leukemia_Homo sapiens_hsa052210.93726069
72Renal cell carcinoma_Homo sapiens_hsa052110.93720111
73Axon guidance_Homo sapiens_hsa043600.93396350
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.92777250
75Taste transduction_Homo sapiens_hsa047420.91690215
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.91492935
77Endocytosis_Homo sapiens_hsa041440.91404501
78Prolactin signaling pathway_Homo sapiens_hsa049170.91114750
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90343829
80Choline metabolism in cancer_Homo sapiens_hsa052310.90180654
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90038206
82Primary immunodeficiency_Homo sapiens_hsa053400.89846200
83Herpes simplex infection_Homo sapiens_hsa051680.86040368
84Measles_Homo sapiens_hsa051620.84701030
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84097868
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83834034
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83398929
88Type I diabetes mellitus_Homo sapiens_hsa049400.81474517
89Melanogenesis_Homo sapiens_hsa049160.80274504
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.79437120
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79144745
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77445375
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75864433
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.75578600
95Apoptosis_Homo sapiens_hsa042100.75493318
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75393934
97Serotonergic synapse_Homo sapiens_hsa047260.75377964
98Pancreatic cancer_Homo sapiens_hsa052120.75082021
99Amoebiasis_Homo sapiens_hsa051460.74359326
100Insulin signaling pathway_Homo sapiens_hsa049100.73741213
101Asthma_Homo sapiens_hsa053100.73582959
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72859805
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72668595
104Oocyte meiosis_Homo sapiens_hsa041140.72051193
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.71929785
106Platelet activation_Homo sapiens_hsa046110.71820839
107HTLV-I infection_Homo sapiens_hsa051660.71441922
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71371585
109Inositol phosphate metabolism_Homo sapiens_hsa005620.70176416
110Focal adhesion_Homo sapiens_hsa045100.69541758
111Prostate cancer_Homo sapiens_hsa052150.69457557
112Lysosome_Homo sapiens_hsa041420.67813276
113Rap1 signaling pathway_Homo sapiens_hsa040150.67388999
114Pertussis_Homo sapiens_hsa051330.67264134
115Antigen processing and presentation_Homo sapiens_hsa046120.66843791
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65901861
117Tuberculosis_Homo sapiens_hsa051520.64861304
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63954098
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63619745
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61887389
121Lysine degradation_Homo sapiens_hsa003100.61810716
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.60415322
123Viral myocarditis_Homo sapiens_hsa054160.60369570
124Dilated cardiomyopathy_Homo sapiens_hsa054140.59496405
125Epstein-Barr virus infection_Homo sapiens_hsa051690.58935953
126HIF-1 signaling pathway_Homo sapiens_hsa040660.58900515
127Notch signaling pathway_Homo sapiens_hsa043300.58685347
128Proteoglycans in cancer_Homo sapiens_hsa052050.58205189
129Leishmaniasis_Homo sapiens_hsa051400.56649591
130Pancreatic secretion_Homo sapiens_hsa049720.55994291
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.55543845
132Glucagon signaling pathway_Homo sapiens_hsa049220.54975399
133Toxoplasmosis_Homo sapiens_hsa051450.54829464
134Insulin resistance_Homo sapiens_hsa049310.54460903
135Thyroid hormone synthesis_Homo sapiens_hsa049180.53878990
136Ras signaling pathway_Homo sapiens_hsa040140.53866784
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53779964
138Salmonella infection_Homo sapiens_hsa051320.53572552
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.53479781

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