ZMYM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)3.73911465
2pre-miRNA processing (GO:0031054)3.69765204
3mitotic sister chromatid cohesion (GO:0007064)3.63732826
4central nervous system projection neuron axonogenesis (GO:0021952)3.38794652
5axonal fasciculation (GO:0007413)3.35706355
6regulation of histone H3-K9 methylation (GO:0051570)3.31607906
7presynaptic membrane organization (GO:0097090)3.31034187
8establishment of nucleus localization (GO:0040023)3.25861576
9regulation of gene silencing by RNA (GO:0060966)3.24683368
10regulation of posttranscriptional gene silencing (GO:0060147)3.24683368
11regulation of gene silencing by miRNA (GO:0060964)3.24683368
12layer formation in cerebral cortex (GO:0021819)3.13713202
13regulation of RNA export from nucleus (GO:0046831)3.12842156
14genitalia morphogenesis (GO:0035112)3.11455161
15nuclear pore complex assembly (GO:0051292)3.09709595
16stress granule assembly (GO:0034063)3.08561908
17organ growth (GO:0035265)3.03395018
18histone H3-K9 demethylation (GO:0033169)3.03187169
19histone H3-K36 demethylation (GO:0070544)3.02941533
20regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99753105
21phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.98692873
22cerebellar Purkinje cell differentiation (GO:0021702)2.96389177
23neuron recognition (GO:0008038)2.96256965
24nuclear pore organization (GO:0006999)2.95755623
25anterior/posterior axis specification, embryo (GO:0008595)2.93058328
26mRNA splice site selection (GO:0006376)2.90128302
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.88925217
28regulation of centriole replication (GO:0046599)2.87845552
29histone H3-K4 trimethylation (GO:0080182)2.87797583
30synaptic vesicle maturation (GO:0016188)2.86548797
31positive regulation of dendritic spine morphogenesis (GO:0061003)2.84326567
32nucleus localization (GO:0051647)2.83865838
33embryonic retina morphogenesis in camera-type eye (GO:0060059)2.83228203
34lateral sprouting from an epithelium (GO:0060601)2.82331086
35regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.81232075
36microtubule anchoring (GO:0034453)2.78436894
37cell migration in hindbrain (GO:0021535)2.77937803
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.77217246
39synaptic vesicle docking involved in exocytosis (GO:0016081)2.76693535
40presynaptic membrane assembly (GO:0097105)2.75997618
41protein localization to synapse (GO:0035418)2.74341918
42prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.74130475
43positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.74096149
44interkinetic nuclear migration (GO:0022027)2.73788969
45dendrite morphogenesis (GO:0048813)2.73448679
46central nervous system neuron axonogenesis (GO:0021955)2.72681168
47cytoplasmic mRNA processing body assembly (GO:0033962)2.72185422
48regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.67971780
49innervation (GO:0060384)2.67883418
50ionotropic glutamate receptor signaling pathway (GO:0035235)2.65266992
51regulation of nucleobase-containing compound transport (GO:0032239)2.64364329
52chromatin remodeling at centromere (GO:0031055)2.63751303
53otic vesicle formation (GO:0030916)2.62654811
54positive regulation of synapse maturation (GO:0090129)2.62475396
55regulation of chromatin silencing (GO:0031935)2.62275123
56negative regulation of histone methylation (GO:0031061)2.61998159
57histone lysine demethylation (GO:0070076)2.61614690
58hippo signaling (GO:0035329)2.59986067
59protein prenylation (GO:0018342)2.58253701
60prenylation (GO:0097354)2.58253701
61dendritic spine morphogenesis (GO:0060997)2.57817844
62locomotory exploration behavior (GO:0035641)2.57362475
63negative regulation of translation, ncRNA-mediated (GO:0040033)2.57167269
64regulation of translation, ncRNA-mediated (GO:0045974)2.57167269
65negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.57167269
66positive regulation of mitotic sister chromatid separation (GO:1901970)2.55881410
67positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.55881410
68positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.55881410
69neuron cell-cell adhesion (GO:0007158)2.55867142
70neural tube formation (GO:0001841)2.54157426
71glucocorticoid receptor signaling pathway (GO:0042921)2.53314728
72regulation of non-canonical Wnt signaling pathway (GO:2000050)2.53260185
73adult heart development (GO:0007512)2.52363442
74limb bud formation (GO:0060174)2.51574985
75regulation of gene silencing (GO:0060968)2.51449182
76peptidyl-lysine trimethylation (GO:0018023)2.51370015
77regulation of DNA endoreduplication (GO:0032875)2.51254821
78CENP-A containing nucleosome assembly (GO:0034080)2.50186066
79somite development (GO:0061053)2.50177504
80negative regulation of DNA repair (GO:0045738)2.49755798
81positive regulation of dendrite morphogenesis (GO:0050775)2.48308549
82embryonic camera-type eye morphogenesis (GO:0048596)2.47837016
83histone demethylation (GO:0016577)2.47263427
84regulation of DNA methylation (GO:0044030)2.46827634
85synaptic vesicle exocytosis (GO:0016079)2.46467088
86positive regulation of RNA splicing (GO:0033120)2.46437359
87regulation of growth hormone secretion (GO:0060123)2.46426615
88embryonic foregut morphogenesis (GO:0048617)2.46207887
89regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.44485816
90positive regulation of catenin import into nucleus (GO:0035413)2.44077397
91histone exchange (GO:0043486)2.42929023
92regulation of synaptic vesicle exocytosis (GO:2000300)2.42695444
93dorsal/ventral axis specification (GO:0009950)2.42379510
94mesenchymal cell differentiation (GO:0048762)2.42229545
95neuronal stem cell maintenance (GO:0097150)2.41708345
96cerebellum development (GO:0021549)2.40265474
97glutamate receptor signaling pathway (GO:0007215)2.39388935
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.38163788
99artery development (GO:0060840)2.37957438
100sister chromatid cohesion (GO:0007062)2.37477406
101regulation of telomere maintenance (GO:0032204)2.36239578
102axon extension (GO:0048675)2.34793632
103peptidyl-lysine dimethylation (GO:0018027)2.34737974
104head development (GO:0060322)2.34139302
105regulation of establishment of cell polarity (GO:2000114)2.33163416
106regulation of dendritic spine morphogenesis (GO:0061001)2.33110083
107histone H4-K16 acetylation (GO:0043984)2.32549232
108histone H3-K9 methylation (GO:0051567)2.32252838
109synaptic transmission, glutamatergic (GO:0035249)2.32068844
110morphogenesis of an epithelial sheet (GO:0002011)2.31494360
111regulation of glutamate receptor signaling pathway (GO:1900449)2.30776034
112regulation of neuronal synaptic plasticity (GO:0048168)2.30612733
113positive regulation of SMAD protein import into nucleus (GO:0060391)2.30391775
114regulation of long-term neuronal synaptic plasticity (GO:0048169)2.30147534
115monoubiquitinated protein deubiquitination (GO:0035520)2.29918652
116DNA double-strand break processing (GO:0000729)2.29577631
117regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.29031765
118somite rostral/caudal axis specification (GO:0032525)2.28551159
119regulation of telomere maintenance via telomerase (GO:0032210)2.27914850
120auditory behavior (GO:0031223)2.27614767
121DNA replication-independent nucleosome assembly (GO:0006336)2.27341820
122DNA replication-independent nucleosome organization (GO:0034724)2.27341820
123ectodermal placode formation (GO:0060788)2.26590377
124embryonic axis specification (GO:0000578)2.26204188
125protein demethylation (GO:0006482)2.25676145
126protein dealkylation (GO:0008214)2.25676145
127nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.24963102
128histone H4-K8 acetylation (GO:0043982)2.24118718
129histone H4-K5 acetylation (GO:0043981)2.24118718
130histone lysine methylation (GO:0034968)2.23889419
131lung-associated mesenchyme development (GO:0060484)2.23881348
132vocalization behavior (GO:0071625)2.23733578
133histone H3-K4 methylation (GO:0051568)2.23281485
134regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.22664700
135ATP-dependent chromatin remodeling (GO:0043044)2.21899563
136paraxial mesoderm development (GO:0048339)2.20950397
137pore complex assembly (GO:0046931)2.20478980
138regulation of meiosis I (GO:0060631)2.20409590
139regulation of stem cell maintenance (GO:2000036)2.19748119
140glial cell proliferation (GO:0014009)2.19236350
141establishment of protein localization to Golgi (GO:0072600)2.18520579
142glutamate secretion (GO:0014047)2.18197032
143ncRNA catabolic process (GO:0034661)2.17722291
144cell surface receptor signaling pathway involved in heart development (GO:0061311)2.17615029
145regulation of axon extension involved in axon guidance (GO:0048841)2.17260916
146regulation of NFAT protein import into nucleus (GO:0051532)2.17125616
147regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.17023620
148NLS-bearing protein import into nucleus (GO:0006607)2.16822340
149anterior/posterior axis specification (GO:0009948)2.16398087
150regulation of mRNA splicing, via spliceosome (GO:0048024)2.15891089
151cellular response to cholesterol (GO:0071397)2.15469073
152limb development (GO:0060173)2.15246132
153appendage development (GO:0048736)2.15246132
154regulation of pigment cell differentiation (GO:0050932)2.15160860
155regulation of centrosome duplication (GO:0010824)2.15004566
156regulation of helicase activity (GO:0051095)2.14843414
157neuron-neuron synaptic transmission (GO:0007270)2.14640281
158regulation of cell fate specification (GO:0042659)2.14575960
159cerebral cortex radially oriented cell migration (GO:0021799)2.14238649
160corticosteroid receptor signaling pathway (GO:0031958)2.13823963
161negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.13775879
162behavioral fear response (GO:0001662)2.13593793
163behavioral defense response (GO:0002209)2.13593793
164negative regulation of fibroblast apoptotic process (GO:2000270)2.13565556
165body morphogenesis (GO:0010171)2.13309905
166gastrulation with mouth forming second (GO:0001702)2.12667125
167primitive streak formation (GO:0090009)2.12500380
168intra-S DNA damage checkpoint (GO:0031573)2.12038432
169retrograde transport, vesicle recycling within Golgi (GO:0000301)2.11402407
170prostate gland growth (GO:0060736)2.11362331
171post-anal tail morphogenesis (GO:0036342)2.11230199
172negative regulation of neurotransmitter secretion (GO:0046929)2.09420548

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.03528299
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.42483877
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.08671173
4GBX2_23144817_ChIP-Seq_PC3_Human3.06757439
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88158529
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.72438679
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49556838
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.43695913
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33232628
10FUS_26573619_Chip-Seq_HEK293_Human2.18123498
11SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.13152836
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08660218
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.06497147
14TP63_19390658_ChIP-ChIP_HaCaT_Human1.97586941
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91401270
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87152692
17TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.86231047
18E2F7_22180533_ChIP-Seq_HELA_Human1.85486735
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76791377
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.75002018
21AR_21572438_ChIP-Seq_LNCaP_Human1.72724727
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70520167
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.70339152
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.68102636
25EWS_26573619_Chip-Seq_HEK293_Human1.65285433
26SMAD4_21799915_ChIP-Seq_A2780_Human1.64797674
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63185658
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.62962333
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61270806
30VDR_22108803_ChIP-Seq_LS180_Human1.60019846
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.59949762
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59519465
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58425373
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58425373
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55514125
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55103190
37P300_19829295_ChIP-Seq_ESCs_Human1.54940718
38DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53645594
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.53485851
40IGF1R_20145208_ChIP-Seq_DFB_Human1.51490158
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50656299
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.49168045
43FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.48218006
44TAF15_26573619_Chip-Seq_HEK293_Human1.47134526
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46336243
46ZNF274_21170338_ChIP-Seq_K562_Hela1.46258961
47STAT3_23295773_ChIP-Seq_U87_Human1.45297535
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.44244846
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43827051
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42930215
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42742554
52STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.42738291
53* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42444546
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.42307550
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42013058
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41308914
57YAP1_20516196_ChIP-Seq_MESCs_Mouse1.40600732
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40330594
59FOXM1_26456572_ChIP-Seq_MCF-7_Human1.39894990
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39187340
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38967444
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.38676663
63* ARNT_22903824_ChIP-Seq_MCF-7_Human1.37594135
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37223204
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36659426
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36659426
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36659426
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.36288700
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35895770
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.35245846
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35088140
72ER_23166858_ChIP-Seq_MCF-7_Human1.34668370
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.33456897
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33161921
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33161921
76* RNF2_27304074_Chip-Seq_NSC_Mouse1.32951165
77JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32318295
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31984195
79ISL1_27105846_Chip-Seq_CPCs_Mouse1.29543469
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28826015
81AHR_22903824_ChIP-Seq_MCF-7_Human1.28539316
82REST_21632747_ChIP-Seq_MESCs_Mouse1.28218641
83AR_19668381_ChIP-Seq_PC3_Human1.28069749
84TCF4_23295773_ChIP-Seq_U87_Human1.27803271
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.27708511
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27698395
87* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.27349294
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27034957
89CBP_20019798_ChIP-Seq_JUKART_Human1.27034957
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.26785834
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26707284
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25659545
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.25118953
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24694132
95DROSHA_22980978_ChIP-Seq_HELA_Human1.23910227
96* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21598098
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20188794
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.20151190
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20102701
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19869524
101TP53_16413492_ChIP-PET_HCT116_Human1.19500192
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18952814
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18417337
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16184353
105* RUNX2_22187159_ChIP-Seq_PCA_Human1.15944762
106BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14948307
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14570143
108TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14492319
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14298536
110TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14165911
111SOX2_16153702_ChIP-ChIP_HESCs_Human1.14080161
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13865871
113EZH2_27294783_Chip-Seq_ESCs_Mouse1.13818561
114MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13630037
115EZH2_27294783_Chip-Seq_NPCs_Mouse1.13001942
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12673469
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11768169
118SOX9_26525672_Chip-Seq_HEART_Mouse1.11754076
119AR_25329375_ChIP-Seq_VCAP_Human1.11543277
120SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10685871
121* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09886806
122SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09586293
123ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09128969
124FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09087744
125PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09037450
126E2F1_18555785_Chip-Seq_ESCs_Mouse1.08653327
127BCAT_22108803_ChIP-Seq_LS180_Human1.08410918
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06897493
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.06887689
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06580679
131TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05913635
132WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05850557
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05766300
134VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04828859
135SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03961843
136KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03816720
137SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03228037
138KDM2B_26808549_Chip-Seq_REH_Human1.02529832
139CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01646338
140POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01074323

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.97703664
2MP0000569_abnormal_digit_pigmentation3.68888480
3MP0003787_abnormal_imprinting3.13355774
4MP0004859_abnormal_synaptic_plasticity2.99664051
5MP0003121_genomic_imprinting2.80284613
6MP0003122_maternal_imprinting2.70621371
7MP0003880_abnormal_central_pattern2.46820537
8MP0000383_abnormal_hair_follicle2.38970028
9MP0000778_abnormal_nervous_system2.31968947
10MP0003890_abnormal_embryonic-extraembry2.24655920
11MP0000537_abnormal_urethra_morphology2.09174843
12MP0003941_abnormal_skin_development2.06942008
13MP0003123_paternal_imprinting2.06122097
14MP0005423_abnormal_somatic_nervous2.00346161
15MP0008877_abnormal_DNA_methylation1.97099021
16MP0003635_abnormal_synaptic_transmissio1.96526942
17MP0003567_abnormal_fetal_cardiomyocyte1.93512154
18MP0010678_abnormal_skin_adnexa1.91302567
19MP0005248_abnormal_Harderian_gland1.79936494
20MP0010030_abnormal_orbit_morphology1.77917403
21MP0009780_abnormal_chondrocyte_physiolo1.75209892
22MP0002063_abnormal_learning/memory/cond1.74729585
23MP0005187_abnormal_penis_morphology1.68735977
24MP0004270_analgesia1.68672494
25MP0006292_abnormal_olfactory_placode1.61185624
26MP0000566_synostosis1.57885318
27MP0002009_preneoplasia1.57069412
28MP0006072_abnormal_retinal_apoptosis1.49680656
29MP0001188_hyperpigmentation1.48170290
30MP0000516_abnormal_urinary_system1.44126852
31MP0005367_renal/urinary_system_phenotyp1.44126852
32MP0003861_abnormal_nervous_system1.42657513
33MP0010234_abnormal_vibrissa_follicle1.39818046
34MP0001293_anophthalmia1.39777610
35MP0003119_abnormal_digestive_system1.38592681
36MP0009745_abnormal_behavioral_response1.38254425
37MP0004885_abnormal_endolymph1.36446272
38MP0002184_abnormal_innervation1.35679023
39MP0003385_abnormal_body_wall1.34327485
40MP0001486_abnormal_startle_reflex1.34150961
41MP0002572_abnormal_emotion/affect_behav1.33735097
42MP0003937_abnormal_limbs/digits/tail_de1.32332593
43MP0005394_taste/olfaction_phenotype1.31706517
44MP0005499_abnormal_olfactory_system1.31706517
45MP0005076_abnormal_cell_differentiation1.30875374
46MP0004811_abnormal_neuron_physiology1.28297529
47MP0010094_abnormal_chromosome_stability1.26367687
48MP0003935_abnormal_craniofacial_develop1.26304491
49MP0009053_abnormal_anal_canal1.24836079
50MP0000955_abnormal_spinal_cord1.23563499
51MP0010307_abnormal_tumor_latency1.22658870
52MP0000631_abnormal_neuroendocrine_gland1.22656027
53MP0004233_abnormal_muscle_weight1.22541192
54MP0002152_abnormal_brain_morphology1.21204516
55MP0004957_abnormal_blastocyst_morpholog1.18434203
56MP0002938_white_spotting1.17879761
57MP0000428_abnormal_craniofacial_morphol1.17619373
58MP0002088_abnormal_embryonic_growth/wei1.17572208
59MP0002064_seizures1.17472290
60MP0010352_gastrointestinal_tract_polyps1.17451193
61MP0005380_embryogenesis_phenotype1.16301521
62MP0001672_abnormal_embryogenesis/_devel1.16301521
63MP0003984_embryonic_growth_retardation1.16165165
64MP0003115_abnormal_respiratory_system1.15528450
65MP0003755_abnormal_palate_morphology1.15276485
66MP0002822_catalepsy1.13849491
67MP0005171_absent_coat_pigmentation1.13321773
68MP0002084_abnormal_developmental_patter1.13060785
69MP0008789_abnormal_olfactory_epithelium1.10900461
70MP0001299_abnormal_eye_distance/1.10366143
71MP0002557_abnormal_social/conspecific_i1.09990948
72MP0002882_abnormal_neuron_morphology1.09902712
73MP0002233_abnormal_nose_morphology1.08203961
74MP0004264_abnormal_extraembryonic_tissu1.05772847
75MP0003077_abnormal_cell_cycle1.04839305
76MP0003942_abnormal_urinary_system1.03587745
77MP0000579_abnormal_nail_morphology1.03537798
78MP0000534_abnormal_ureter_morphology1.03268082
79MP0002653_abnormal_ependyma_morphology1.02099033
80MP0009703_decreased_birth_body1.02017439
81MP0002116_abnormal_craniofacial_bone1.01624185
82MP0009046_muscle_twitch1.01555966
83MP0000462_abnormal_digestive_system1.00952614
84MP0002111_abnormal_tail_morphology1.00024429
85MP0002751_abnormal_autonomic_nervous0.99768331
86MP0008058_abnormal_DNA_repair0.99546683
87MP0001697_abnormal_embryo_size0.97847527
88MP0001485_abnormal_pinna_reflex0.97778449
89MP0005551_abnormal_eye_electrophysiolog0.97772899
90MP0004133_heterotaxia0.97606356
91MP0003693_abnormal_embryo_hatching0.97549066
92MP0002396_abnormal_hematopoietic_system0.96085737
93MP0002081_perinatal_lethality0.95837857
94MP0003878_abnormal_ear_physiology0.95169946
95MP0005377_hearing/vestibular/ear_phenot0.95169946
96MP0002234_abnormal_pharynx_morphology0.94864669
97MP0009697_abnormal_copulation0.94261681
98MP0005623_abnormal_meninges_morphology0.94012177
99MP0002734_abnormal_mechanical_nocicepti0.93592401
100MP0005409_darkened_coat_color0.93158440
101MP0000647_abnormal_sebaceous_gland0.93154797
102MP0002067_abnormal_sensory_capabilities0.92662853
103MP0004197_abnormal_fetal_growth/weight/0.92014272
104MP0003136_yellow_coat_color0.91783889
105MP0000049_abnormal_middle_ear0.91579603
106MP0001984_abnormal_olfaction0.90864738
107MP0008569_lethality_at_weaning0.90059452
108MP0001286_abnormal_eye_development0.89443504
109MP0005386_behavior/neurological_phenoty0.88749499
110MP0004924_abnormal_behavior0.88749499
111MP0002085_abnormal_embryonic_tissue0.88070663
112MP0000427_abnormal_hair_cycle0.87061453
113MP0002272_abnormal_nervous_system0.86433826
114MP0002086_abnormal_extraembryonic_tissu0.85705233
115MP0002177_abnormal_outer_ear0.84371922
116MP0002092_abnormal_eye_morphology0.83956397
117MP0005391_vision/eye_phenotype0.83108511
118MP0005253_abnormal_eye_physiology0.82866356
119MP0003718_maternal_effect0.81878067
120MP0009250_abnormal_appendicular_skeleto0.81044898
121MP0000432_abnormal_head_morphology0.80647228
122MP0008932_abnormal_embryonic_tissue0.80538591
123MP0001346_abnormal_lacrimal_gland0.80237641
124MP0001730_embryonic_growth_arrest0.80203971
125MP0002254_reproductive_system_inflammat0.79004046
126MP0002932_abnormal_joint_morphology0.78238428
127MP0002697_abnormal_eye_size0.77850833
128MP0003283_abnormal_digestive_organ0.77297153
129MP0002114_abnormal_axial_skeleton0.75626079
130MP0006276_abnormal_autonomic_nervous0.74239169
131MP0005646_abnormal_pituitary_gland0.73901405
132MP0001440_abnormal_grooming_behavior0.73578090
133MP0000733_abnormal_muscle_development0.73177014
134MP0001943_abnormal_respiration0.73099039
135MP0002925_abnormal_cardiovascular_devel0.72414927
136MP0001177_atelectasis0.71008980
137MP0002102_abnormal_ear_morphology0.70513903
138MP0009672_abnormal_birth_weight0.70151100

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.52571595
2Short 4th metacarpal (HP:0010044)3.10989498
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.10989498
4Papillary thyroid carcinoma (HP:0002895)2.95550176
5Embryonal renal neoplasm (HP:0011794)2.79059436
6Nephroblastoma (Wilms tumor) (HP:0002667)2.78267167
7Rhabdomyosarcoma (HP:0002859)2.69977690
8Macroorchidism (HP:0000053)2.57923071
9Excessive salivation (HP:0003781)2.57628190
10Drooling (HP:0002307)2.57628190
11Hepatoblastoma (HP:0002884)2.56850140
12Intestinal atresia (HP:0011100)2.48300075
13Cupped ear (HP:0000378)2.41660721
14Midline defect of the nose (HP:0004122)2.33380815
15Abnormality of the 4th metacarpal (HP:0010012)2.29327607
16Protruding tongue (HP:0010808)2.28047423
17Neoplasm of striated muscle (HP:0009728)2.27804920
18Astrocytoma (HP:0009592)2.27151512
19Abnormality of the astrocytes (HP:0100707)2.27151512
20Shoulder girdle muscle weakness (HP:0003547)2.25728625
21Obsessive-compulsive behavior (HP:0000722)2.25522508
22Abnormality of the lower motor neuron (HP:0002366)2.24594576
23Chronic hepatic failure (HP:0100626)2.23786409
24Septo-optic dysplasia (HP:0100842)2.20871781
25Focal motor seizures (HP:0011153)2.19398788
26Abnormality of the nasal septum (HP:0000419)2.16210145
27Tubulointerstitial nephritis (HP:0001970)2.13997965
28Heterotopia (HP:0002282)2.13085598
29Trigonocephaly (HP:0000243)2.10680237
30Neoplasm of the adrenal cortex (HP:0100641)2.09982118
31Aqueductal stenosis (HP:0002410)2.09844714
32Focal seizures (HP:0007359)2.08246252
33Chromsome breakage (HP:0040012)2.07702517
34Transitional cell carcinoma of the bladder (HP:0006740)2.07241463
35Febrile seizures (HP:0002373)2.06481930
36Broad-based gait (HP:0002136)2.06471217
37Myelomeningocele (HP:0002475)2.05358979
38Abnormality of chromosome stability (HP:0003220)2.03125724
39Progressive cerebellar ataxia (HP:0002073)2.02201840
40Medulloblastoma (HP:0002885)2.01977651
41Tented upper lip vermilion (HP:0010804)2.01745637
42Curly hair (HP:0002212)2.01156896
43Genetic anticipation (HP:0003743)2.01049491
44Gonadotropin excess (HP:0000837)1.99787561
45Subacute progressive viral hepatitis (HP:0006572)1.98320169
46Narrow palate (HP:0000189)1.97627731
47Bifid tongue (HP:0010297)1.96717366
48Absent speech (HP:0001344)1.96602172
49Epileptic encephalopathy (HP:0200134)1.95347553
50Anal stenosis (HP:0002025)1.93111074
51Glioma (HP:0009733)1.92972270
52Renal duplication (HP:0000075)1.92317784
53Colon cancer (HP:0003003)1.91465408
54Biliary tract neoplasm (HP:0100574)1.91015588
55Preaxial foot polydactyly (HP:0001841)1.90869562
56Bladder neoplasm (HP:0009725)1.90835235
57Bladder carcinoma (HP:0002862)1.90835235
58Inappropriate behavior (HP:0000719)1.90162745
59Increased nuchal translucency (HP:0010880)1.90023826
60Vertebral arch anomaly (HP:0008438)1.89983254
61Truncal obesity (HP:0001956)1.89039193
62Acute myeloid leukemia (HP:0004808)1.88829839
63Thyroid carcinoma (HP:0002890)1.86850726
64Pelvic girdle muscle weakness (HP:0003749)1.86542370
65Genital tract atresia (HP:0001827)1.86357620
66Abnormality of the labia minora (HP:0012880)1.86315447
67Neoplasm of the oral cavity (HP:0100649)1.85338131
68Impaired vibration sensation in the lower limbs (HP:0002166)1.85204507
69Hypoplastic labia majora (HP:0000059)1.84373754
70Abnormality of chromosome segregation (HP:0002916)1.83800419
71Abnormality of the pubic bones (HP:0003172)1.82783408
72Acute lymphatic leukemia (HP:0006721)1.82699174
73Vitreoretinal degeneration (HP:0000655)1.82317537
74Uterine leiomyosarcoma (HP:0002891)1.81114381
75Leiomyosarcoma (HP:0100243)1.81114381
76Abnormality of the musculature of the pelvis (HP:0001469)1.80770642
77Abnormality of the hip-girdle musculature (HP:0001445)1.80770642
78Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80246787
79Gastrointestinal atresia (HP:0002589)1.80212229
80Vaginal atresia (HP:0000148)1.79514324
81Abnormality of the parathyroid morphology (HP:0011766)1.79145205
82Exotropia (HP:0000577)1.78710074
83Partial agenesis of the corpus callosum (HP:0001338)1.78251416
84Buphthalmos (HP:0000557)1.78177172
85Abnormality of the fingertips (HP:0001211)1.76723441
86Increased number of teeth (HP:0011069)1.76675052
87Smooth philtrum (HP:0000319)1.76534825
88Hypoplasia of the maxilla (HP:0000327)1.75663595
892-3 toe syndactyly (HP:0004691)1.75260565
90Urinary bladder sphincter dysfunction (HP:0002839)1.74114660
91Abnormality of salivation (HP:0100755)1.73955050
92Absent eyebrow (HP:0002223)1.72577291
93Cutaneous finger syndactyly (HP:0010554)1.71559949
94Renal hypoplasia (HP:0000089)1.71538710
95Widely spaced teeth (HP:0000687)1.71505245
96Abnormality of the phalanges of the 2nd finger (HP:0009541)1.71266640
97Long eyelashes (HP:0000527)1.70740319
98Embryonal neoplasm (HP:0002898)1.70275410
99Abnormality of the septum pellucidum (HP:0007375)1.69958946
100Esophageal atresia (HP:0002032)1.69934260
101Lip pit (HP:0100267)1.69685539
102High anterior hairline (HP:0009890)1.69644682
103Deep philtrum (HP:0002002)1.69475730
104Sacral dimple (HP:0000960)1.68370194
105Urinary urgency (HP:0000012)1.67184416
106Thickened helices (HP:0000391)1.66483615
107Labial hypoplasia (HP:0000066)1.66173115
108Ectopic kidney (HP:0000086)1.66169414
109Overgrowth (HP:0001548)1.66031514
110Abnormality of the ischium (HP:0003174)1.65920934
111Neoplasm of the small intestine (HP:0100833)1.65113779
112Abnormality of the labia majora (HP:0012881)1.64695952
113Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.64525637
114Hyperacusis (HP:0010780)1.64174076
115Intellectual disability, profound (HP:0002187)1.63633377
116Omphalocele (HP:0001539)1.63287153
117Abnormal hair whorl (HP:0010721)1.62956468
118Malignant gastrointestinal tract tumors (HP:0006749)1.62873000
119Gastrointestinal carcinoma (HP:0002672)1.62873000
120Cystic hygroma (HP:0000476)1.62408129
121Abnormal lung lobation (HP:0002101)1.62322743
122Open mouth (HP:0000194)1.61977923
123Microglossia (HP:0000171)1.61906192
124Anophthalmia (HP:0000528)1.60956594
125Supernumerary ribs (HP:0005815)1.60722967
126Stenosis of the external auditory canal (HP:0000402)1.60666774
127Truncal ataxia (HP:0002078)1.60584147
128Impaired smooth pursuit (HP:0007772)1.60535170
129Ankyloglossia (HP:0010296)1.60486551
130Neonatal hypoglycemia (HP:0001998)1.59407472
131Pointed chin (HP:0000307)1.59203336
132Oligodactyly (hands) (HP:0001180)1.59112592
133Long nose (HP:0003189)1.58257383
134Morphological abnormality of the middle ear (HP:0008609)1.58080430
135Cutaneous syndactyly (HP:0012725)1.56421692
136Cutis marmorata (HP:0000965)1.56121300
137Attention deficit hyperactivity disorder (HP:0007018)1.55725298
138Amyotrophic lateral sclerosis (HP:0007354)1.55540367
139Nephronophthisis (HP:0000090)1.55212221
140Growth hormone deficiency (HP:0000824)1.53767269
141Poor coordination (HP:0002370)1.53719079
142Optic nerve hypoplasia (HP:0000609)1.53187780
143Large earlobe (HP:0009748)1.53007756
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.52425732
145Urethral obstruction (HP:0000796)1.52346847
146Congenital stationary night blindness (HP:0007642)1.52271737
147Absent hair (HP:0002298)1.52193450
148Hyperventilation (HP:0002883)1.52006228
149Elfin facies (HP:0004428)1.51958880
150Absent radius (HP:0003974)1.51670505
151Autism (HP:0000717)1.51667618
152Absent frontal sinuses (HP:0002688)1.51464641
153Abnormality of ocular smooth pursuit (HP:0000617)1.50669506
154Megalencephaly (HP:0001355)1.50553629
155Skull defect (HP:0001362)1.50550939
156Vesicoureteral reflux (HP:0000076)1.50197420
157Abnormality of the renal medulla (HP:0100957)1.48757715

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.05855041
2MAP3K42.82166132
3BRD42.63544849
4MARK12.63019222
5NTRK32.54691944
6CDK122.54270830
7NLK2.47736164
8ERBB32.44578718
9KSR12.31738870
10EPHA42.23388297
11PNCK2.06812466
12LATS11.93462968
13FGFR21.87654327
14CAMK1G1.85441283
15SGK21.79346434
16CDC71.75916244
17SIK21.65694943
18BRSK21.62919331
19MAP2K71.61918065
20TRIM281.60023821
21STK38L1.58387169
22FGFR31.50776481
23MINK11.49537487
24EPHA31.49182530
25SGK31.48126507
26TAF11.45822605
27MAP3K91.43323336
28AKT31.35881257
29SGK4941.35438169
30SGK2231.35438169
31PKN21.35406734
32PLK41.30805000
33WNK31.29586142
34NTRK21.28856190
35CAMK1D1.22879040
36CSNK1G21.22019857
37MAP2K41.21029556
38BMPR1B1.19319540
39CSNK1A1L1.17577396
40WEE11.16668254
41PLK21.14999999
42SIK31.12604460
43CASK1.11276976
44INSRR1.09644150
45STK241.07015935
46MAPK131.06289786
47CDK91.04136465
48BCR1.03859100
49* FGFR11.03216979
50DYRK31.00351203
51FRK0.97429806
52TTK0.97215659
53FLT30.96672062
54PDGFRA0.96005917
55RET0.95320935
56SGK10.93580416
57PLK30.93568713
58DYRK1A0.91548347
59YES10.90721011
60SRPK10.90643063
61MKNK20.88770622
62STK390.88416612
63PRKD30.87027746
64WNK10.86080191
65PAK60.85624871
66MAP3K20.85420072
67MKNK10.85403406
68PIK3CA0.85084155
69STK30.84803788
70PASK0.84230247
71EIF2AK30.84153568
72OBSCN0.84128617
73CDK50.80383362
74UHMK10.80060741
75ATR0.79476714
76ZAK0.79024475
77CSNK1G30.78162460
78ICK0.76565805
79CDK30.76516073
80EPHB20.75654928
81TSSK60.74745575
82MTOR0.73967259
83MARK20.73409383
84MAPK100.73324517
85CSNK1G10.73001931
86MELK0.71815044
87ATM0.71292350
88TYRO30.71212358
89KSR20.69911469
90CDK60.69817765
91MAPK70.68953483
92TGFBR10.68772245
93MAP3K100.68266443
94ALK0.67449623
95CHEK10.67327249
96PTK60.66462203
97PAK30.64179960
98CSNK1D0.63015757
99* GSK3B0.62812395
100NUAK10.62726722
101CDK10.62315985
102RPS6KB10.61843908
103PDGFRB0.60666655
104FER0.60444216
105STK380.59190919
106MAP4K20.59062793
107NEK60.58958535
108EEF2K0.58947858
109* MAPK80.58803805
110MAP3K70.57781059
111CSNK1E0.57234824
112ERBB20.57132833
113SCYL20.57003625
114EIF2AK20.56434350
115MAPK140.56195406
116MAP3K60.54561450
117* CDK20.54031845
118RPS6KB20.53828049
119STK110.53465266
120PBK0.53260723
121RPS6KA40.53197076
122PRKDC0.51200028
123DAPK10.50987260
124RPS6KA30.50229706
125CDC42BPA0.48863641
126ACVR1B0.48680565
127CHEK20.48308676
128CAMK40.48036439
129PRPF4B0.45240925
130RIPK10.44984912
131DYRK1B0.42275744
132NEK90.40417633
133MET0.38968827
134OXSR10.37916502

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034502.33652279
2Nicotine addiction_Homo sapiens_hsa050332.32342683
3Long-term potentiation_Homo sapiens_hsa047201.91507847
4Circadian entrainment_Homo sapiens_hsa047131.85202870
5Amphetamine addiction_Homo sapiens_hsa050311.72380016
6Dopaminergic synapse_Homo sapiens_hsa047281.68355001
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64461896
8Axon guidance_Homo sapiens_hsa043601.62541308
9Colorectal cancer_Homo sapiens_hsa052101.60025000
10Glutamatergic synapse_Homo sapiens_hsa047241.59215805
11Basal transcription factors_Homo sapiens_hsa030221.58704794
12Morphine addiction_Homo sapiens_hsa050321.55091083
13Endometrial cancer_Homo sapiens_hsa052131.54222888
14Fanconi anemia pathway_Homo sapiens_hsa034601.51851550
15Olfactory transduction_Homo sapiens_hsa047401.49142172
16mRNA surveillance pathway_Homo sapiens_hsa030151.46776642
17GABAergic synapse_Homo sapiens_hsa047271.46582976
18Renin secretion_Homo sapiens_hsa049241.46163608
19Basal cell carcinoma_Homo sapiens_hsa052171.45591434
20Dorso-ventral axis formation_Homo sapiens_hsa043201.39341550
21RNA transport_Homo sapiens_hsa030131.37239273
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36698389
23Cholinergic synapse_Homo sapiens_hsa047251.36051939
24Wnt signaling pathway_Homo sapiens_hsa043101.35045501
25Cocaine addiction_Homo sapiens_hsa050301.34303270
26Type II diabetes mellitus_Homo sapiens_hsa049301.33193249
27Long-term depression_Homo sapiens_hsa047301.31967138
28Insulin secretion_Homo sapiens_hsa049111.30746646
29mTOR signaling pathway_Homo sapiens_hsa041501.29657967
30Phototransduction_Homo sapiens_hsa047441.28646484
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27534246
32Oocyte meiosis_Homo sapiens_hsa041141.27234813
33Synaptic vesicle cycle_Homo sapiens_hsa047211.25159578
34Thyroid cancer_Homo sapiens_hsa052161.24564382
35Hippo signaling pathway_Homo sapiens_hsa043901.24228024
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23452450
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22654695
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22083250
39ErbB signaling pathway_Homo sapiens_hsa040121.21550577
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20343033
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19732149
42Glioma_Homo sapiens_hsa052141.19202683
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18764630
44Oxytocin signaling pathway_Homo sapiens_hsa049211.18739669
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17935951
46Melanogenesis_Homo sapiens_hsa049161.16939162
47Hedgehog signaling pathway_Homo sapiens_hsa043401.16095033
48Taste transduction_Homo sapiens_hsa047421.15467337
49Propanoate metabolism_Homo sapiens_hsa006401.15154459
50Adherens junction_Homo sapiens_hsa045201.14496291
51MicroRNAs in cancer_Homo sapiens_hsa052061.13420316
52Homologous recombination_Homo sapiens_hsa034401.13335397
53Salivary secretion_Homo sapiens_hsa049701.12987194
54RNA degradation_Homo sapiens_hsa030181.12350398
55Estrogen signaling pathway_Homo sapiens_hsa049151.12191652
56Gap junction_Homo sapiens_hsa045401.10771228
57cAMP signaling pathway_Homo sapiens_hsa040241.07089667
58Serotonergic synapse_Homo sapiens_hsa047261.05973411
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02854659
60Alcoholism_Homo sapiens_hsa050341.02428955
61Non-small cell lung cancer_Homo sapiens_hsa052231.00689994
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00361962
63Gastric acid secretion_Homo sapiens_hsa049710.99244436
64GnRH signaling pathway_Homo sapiens_hsa049120.98523865
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98348221
66Choline metabolism in cancer_Homo sapiens_hsa052310.97593910
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97585526
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96596255
69Mismatch repair_Homo sapiens_hsa034300.96459364
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95485556
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95330310
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93105516
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.93091152
74Circadian rhythm_Homo sapiens_hsa047100.92791611
75Spliceosome_Homo sapiens_hsa030400.91962399
76TGF-beta signaling pathway_Homo sapiens_hsa043500.90531005
77Systemic lupus erythematosus_Homo sapiens_hsa053220.89857063
78MAPK signaling pathway_Homo sapiens_hsa040100.89708665
79Chronic myeloid leukemia_Homo sapiens_hsa052200.87085339
80Notch signaling pathway_Homo sapiens_hsa043300.86823480
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86475091
82Renal cell carcinoma_Homo sapiens_hsa052110.85204501
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84887751
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84558978
85Calcium signaling pathway_Homo sapiens_hsa040200.83999208
86Selenocompound metabolism_Homo sapiens_hsa004500.83125930
87Prostate cancer_Homo sapiens_hsa052150.82838769
88Pancreatic cancer_Homo sapiens_hsa052120.81999015
89FoxO signaling pathway_Homo sapiens_hsa040680.81604368
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80786563
91Rap1 signaling pathway_Homo sapiens_hsa040150.79629283
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79346197
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.79201901
94Proteoglycans in cancer_Homo sapiens_hsa052050.78534537
95Glucagon signaling pathway_Homo sapiens_hsa049220.77701867
96Inositol phosphate metabolism_Homo sapiens_hsa005620.76430346
97Lysine degradation_Homo sapiens_hsa003100.75335018
98Cell cycle_Homo sapiens_hsa041100.72631791
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71628072
100p53 signaling pathway_Homo sapiens_hsa041150.71104180
101Ras signaling pathway_Homo sapiens_hsa040140.70427733
102Pathways in cancer_Homo sapiens_hsa052000.69887112
103Dilated cardiomyopathy_Homo sapiens_hsa054140.69410000
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.68866311
105T cell receptor signaling pathway_Homo sapiens_hsa046600.68521169
106Small cell lung cancer_Homo sapiens_hsa052220.68181396
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.67896802
108VEGF signaling pathway_Homo sapiens_hsa043700.66389139
109Melanoma_Homo sapiens_hsa052180.65977145
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65344126
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64226680
112Tight junction_Homo sapiens_hsa045300.62748479
113Viral carcinogenesis_Homo sapiens_hsa052030.62288773
114HTLV-I infection_Homo sapiens_hsa051660.61662295
115Insulin signaling pathway_Homo sapiens_hsa049100.59920694
116Prolactin signaling pathway_Homo sapiens_hsa049170.59450212
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59145899
118Focal adhesion_Homo sapiens_hsa045100.59142227
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58100155
120Ether lipid metabolism_Homo sapiens_hsa005650.57018871
121Fatty acid biosynthesis_Homo sapiens_hsa000610.56839619
122AMPK signaling pathway_Homo sapiens_hsa041520.56433833
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55702557
124Thyroid hormone synthesis_Homo sapiens_hsa049180.55637740
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53028625
126Steroid biosynthesis_Homo sapiens_hsa001000.52732378

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