ZMYM6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.61185302
2postsynaptic membrane organization (GO:0001941)4.13338480
3presynaptic membrane organization (GO:0097090)4.08745541
4regulation of B cell receptor signaling pathway (GO:0050855)4.05044780
5negative regulation of synaptic transmission, GABAergic (GO:0032229)3.83988626
6positive regulation of gamma-delta T cell activation (GO:0046645)3.79728873
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.74517221
8protein K11-linked deubiquitination (GO:0035871)3.71656069
9positive regulation of granulocyte differentiation (GO:0030854)3.58731880
10neurotransmitter-gated ion channel clustering (GO:0072578)3.55815288
11L-fucose catabolic process (GO:0042355)3.53489271
12fucose catabolic process (GO:0019317)3.53489271
13L-fucose metabolic process (GO:0042354)3.53489271
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.49863245
15regulation of memory T cell differentiation (GO:0043380)3.46406502
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.44202625
17neuron cell-cell adhesion (GO:0007158)3.35017274
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.26991176
19positive regulation of B cell differentiation (GO:0045579)3.25683319
20regulation of gamma-delta T cell differentiation (GO:0045586)3.24298673
21regulation of gamma-delta T cell activation (GO:0046643)3.17317889
22synaptic transmission, glutamatergic (GO:0035249)3.15630179
23cranial nerve structural organization (GO:0021604)3.12891235
24righting reflex (GO:0060013)3.12329633
25regulation of short-term neuronal synaptic plasticity (GO:0048172)3.12039959
26organelle membrane fusion (GO:0090174)3.06541189
27cAMP catabolic process (GO:0006198)3.06464535
28vocalization behavior (GO:0071625)3.05984942
29activated T cell proliferation (GO:0050798)3.05631860
30neural tube formation (GO:0001841)3.05380969
31protein localization to synapse (GO:0035418)3.04891462
32cyclic nucleotide catabolic process (GO:0009214)3.04497129
33facial nerve structural organization (GO:0021612)3.04347397
34interferon-gamma production (GO:0032609)3.03349924
35DNA deamination (GO:0045006)3.03327552
36regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.01976355
37negative regulation of mast cell activation (GO:0033004)3.01704715
38glutamate receptor signaling pathway (GO:0007215)3.01497752
39startle response (GO:0001964)3.00987279
40regulation of hexokinase activity (GO:1903299)3.00439199
41regulation of glucokinase activity (GO:0033131)3.00439199
42detection of light stimulus involved in sensory perception (GO:0050962)2.99036782
43detection of light stimulus involved in visual perception (GO:0050908)2.99036782
44signal peptide processing (GO:0006465)2.98569063
45regulation of glutamate receptor signaling pathway (GO:1900449)2.95016623
46long-term memory (GO:0007616)2.91464036
47histone H3-K4 trimethylation (GO:0080182)2.90902641
48regulation of germinal center formation (GO:0002634)2.87612795
49positive regulation of dendritic spine morphogenesis (GO:0061003)2.87315198
50negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.86588118
51negative regulation of cell killing (GO:0031342)2.86588118
52positive regulation of defense response to virus by host (GO:0002230)2.82820805
53cellular extravasation (GO:0045123)2.82243035
54cell differentiation involved in metanephros development (GO:0072202)2.82169999
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80468831
56negative regulation of T-helper cell differentiation (GO:0045623)2.79083279
57negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.79083279
58L-amino acid import (GO:0043092)2.78712328
59antigen processing and presentation via MHC class Ib (GO:0002475)2.76684681
60regulation of B cell differentiation (GO:0045577)2.76185394
61central nervous system neuron axonogenesis (GO:0021955)2.76064437
62establishment of protein localization to Golgi (GO:0072600)2.75346147
63neuronal action potential propagation (GO:0019227)2.72574681
64neutrophil activation involved in immune response (GO:0002283)2.72153631
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71758551
66regulation of mast cell activation (GO:0033003)2.71508841
67neuron-neuron synaptic transmission (GO:0007270)2.71464259
68photoreceptor cell maintenance (GO:0045494)2.71422827
69central nervous system projection neuron axonogenesis (GO:0021952)2.71146646
70adaptation of signaling pathway (GO:0023058)2.71133642
71negative regulation of T cell mediated immunity (GO:0002710)2.70491783
72mast cell activation (GO:0045576)2.69938151
73indolalkylamine metabolic process (GO:0006586)2.69928387
74regulation of synaptic vesicle exocytosis (GO:2000300)2.68956164
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68413996
76autophagic vacuole fusion (GO:0000046)2.67857475
77negative T cell selection (GO:0043383)2.65345724
78positive regulation of synaptic transmission, GABAergic (GO:0032230)2.64917436
79locomotory exploration behavior (GO:0035641)2.63347229
80mast cell degranulation (GO:0043303)2.63121391
81mast cell activation involved in immune response (GO:0002279)2.63121391
82positive regulation of T-helper 1 type immune response (GO:0002827)2.62317446
83indole-containing compound catabolic process (GO:0042436)2.62164453
84indolalkylamine catabolic process (GO:0046218)2.62164453
85tryptophan catabolic process (GO:0006569)2.62164453
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.61504656
87negative regulation of translation, ncRNA-mediated (GO:0040033)2.61496227
88regulation of translation, ncRNA-mediated (GO:0045974)2.61496227
89negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.61496227
90regulation of synaptic transmission, GABAergic (GO:0032228)2.60726464
91energy homeostasis (GO:0097009)2.60575051
92definitive hemopoiesis (GO:0060216)2.60447588
93transmission of nerve impulse (GO:0019226)2.59301083
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.59216727
95mechanosensory behavior (GO:0007638)2.59089320
96regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.58702769
97mesenchymal cell differentiation involved in renal system development (GO:2001012)2.58455152
98mesenchymal cell differentiation involved in kidney development (GO:0072161)2.58455152
99antigen processing and presentation of endogenous antigen (GO:0019883)2.58107840
100negative thymic T cell selection (GO:0045060)2.57976332
101developmental pigmentation (GO:0048066)2.57828556
102piRNA metabolic process (GO:0034587)2.57320103
103positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.56482986
104positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.56159914
105regulation of pigment cell differentiation (GO:0050932)2.55968599
106G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.54366388
107regulation of excitatory postsynaptic membrane potential (GO:0060079)2.53882505
108phosphatidylinositol acyl-chain remodeling (GO:0036149)2.53826123
109negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.53701296
110cerebellar Purkinje cell differentiation (GO:0021702)2.52720416
111immunoglobulin mediated immune response (GO:0016064)2.51945208
112positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.51156056
113positive regulation of membrane potential (GO:0045838)2.50371303
114inositol phosphate catabolic process (GO:0071545)2.49062742
115positive regulation of mast cell activation (GO:0033005)2.49052294
116protein localization to cilium (GO:0061512)2.48637433
117G-protein coupled receptor internalization (GO:0002031)2.48598832
118response to pheromone (GO:0019236)2.48476842
119regulation of synaptic vesicle transport (GO:1902803)2.48403807
120dentate gyrus development (GO:0021542)2.47482806
121cellular response to interleukin-15 (GO:0071350)2.47217212
122monoubiquitinated protein deubiquitination (GO:0035520)2.47147060
123protein targeting to Golgi (GO:0000042)2.47123319
124microglial cell activation (GO:0001774)2.47003480
125gamma-aminobutyric acid signaling pathway (GO:0007214)2.45263684
126pyrimidine ribonucleoside catabolic process (GO:0046133)2.44833923
127regulation of postsynaptic membrane potential (GO:0060078)2.44475430
128positive regulation of cellular amide metabolic process (GO:0034250)2.44013567
129regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.43498120
130B cell receptor signaling pathway (GO:0050853)2.43239182
131prenylation (GO:0097354)2.43024872
132protein prenylation (GO:0018342)2.43024872
133positive regulation of T cell mediated cytotoxicity (GO:0001916)2.42072306
134regulation of alpha-beta T cell proliferation (GO:0046640)2.42045426
135regulation of T cell mediated cytotoxicity (GO:0001914)2.41874115
136cellular response to exogenous dsRNA (GO:0071360)2.41856267
137positive regulation of dendritic spine development (GO:0060999)2.41030497
138antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.40601850
139phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.40595840
140positive regulation of CREB transcription factor activity (GO:0032793)2.40471433
141cellular response to ethanol (GO:0071361)2.40120632
142cranial nerve morphogenesis (GO:0021602)2.38989961
143positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.38939649
144regulation of synaptic transmission, glutamatergic (GO:0051966)2.38571492
145regulation of synapse assembly (GO:0051963)2.38496561
146histone mRNA catabolic process (GO:0071044)2.38446486
147regulation of respiratory system process (GO:0044065)2.38282251
148tryptophan metabolic process (GO:0006568)2.38150613
149negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.38087385
150DNA double-strand break processing (GO:0000729)2.37866334
151synaptic vesicle exocytosis (GO:0016079)2.37797707
152platelet dense granule organization (GO:0060155)2.37316619
153neutrophil mediated immunity (GO:0002446)2.36929278
154regulation of granulocyte differentiation (GO:0030852)2.36611939
155positive regulation of synapse assembly (GO:0051965)2.35768710
156auditory behavior (GO:0031223)2.35695687
157regulation of T-helper 1 type immune response (GO:0002825)2.35295722
158cytidine catabolic process (GO:0006216)2.35174066
159cytidine deamination (GO:0009972)2.35174066
160cytidine metabolic process (GO:0046087)2.35174066
161regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.35109519
162cerebral cortex radially oriented cell migration (GO:0021799)2.34691418
163anatomical structure arrangement (GO:0048532)2.34625723
164kynurenine metabolic process (GO:0070189)2.34043476
165regulation of timing of cell differentiation (GO:0048505)2.33413023
166negative regulation of B cell proliferation (GO:0030889)2.33279846
167positive regulation of antigen processing and presentation (GO:0002579)2.32993980
168DNA demethylation (GO:0080111)2.31304283
169inositol phosphate dephosphorylation (GO:0046855)2.30769005
170phosphorylated carbohydrate dephosphorylation (GO:0046838)2.30769005
171response to auditory stimulus (GO:0010996)2.30721442
172reflex (GO:0060004)2.30195542
173T cell migration (GO:0072678)2.29963549
174amino acid import (GO:0043090)2.29435260
175antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.29262545
176regulation of male gonad development (GO:2000018)2.28669158
177retinal cone cell development (GO:0046549)2.28119852
178mechanoreceptor differentiation (GO:0042490)2.27875028
179synaptic vesicle docking involved in exocytosis (GO:0016081)2.26463860
180eye photoreceptor cell development (GO:0042462)2.25955562
181positive regulation of meiosis (GO:0045836)2.25476620
182photoreceptor cell differentiation (GO:0046530)2.23309161
183eye photoreceptor cell differentiation (GO:0001754)2.23309161
184adult walking behavior (GO:0007628)2.22304892
185long-term synaptic potentiation (GO:0060291)2.21887839
186retina layer formation (GO:0010842)2.21195997
187synaptic vesicle maturation (GO:0016188)2.19140147
188intraciliary transport (GO:0042073)2.19134367
189regulation of respiratory gaseous exchange (GO:0043576)2.18579543
190regulation of long-term neuronal synaptic plasticity (GO:0048169)2.17504822
191membrane hyperpolarization (GO:0060081)2.17155257
192photoreceptor cell development (GO:0042461)2.15882879
193nonmotile primary cilium assembly (GO:0035058)2.15631971
194neuron recognition (GO:0008038)2.15418483
195membrane depolarization (GO:0051899)2.14923039
196synaptic vesicle endocytosis (GO:0048488)2.13016503
197calcium ion import (GO:0070509)2.12386040

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.58661460
2GBX2_23144817_ChIP-Seq_PC3_Human4.27532177
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.60021150
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.63686701
5ZNF274_21170338_ChIP-Seq_K562_Hela2.56405639
6VDR_22108803_ChIP-Seq_LS180_Human2.46497996
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30789832
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24046529
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.23387741
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23178194
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12647654
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05409183
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04205103
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03782988
15EED_16625203_ChIP-ChIP_MESCs_Mouse1.99967217
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98155472
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.94683896
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93834665
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89059863
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87910587
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87910587
22DROSHA_22980978_ChIP-Seq_HELA_Human1.86932698
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86849049
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86719947
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86535849
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84436628
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.82173248
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.82156157
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.78465379
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78419806
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75147864
32TAF15_26573619_Chip-Seq_HEK293_Human1.74688766
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74196644
34P300_19829295_ChIP-Seq_ESCs_Human1.73827095
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73550541
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73326692
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.72867606
38SMAD4_21799915_ChIP-Seq_A2780_Human1.70675152
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.69867422
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.66500560
41RUNX_20019798_ChIP-Seq_JUKART_Human1.65500245
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.63452163
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.63298558
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.61979684
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61231602
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60964071
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.60851259
48GATA3_26560356_Chip-Seq_TH2_Human1.59195201
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.58256679
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.56708692
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56163752
52FUS_26573619_Chip-Seq_HEK293_Human1.56099175
53MYB_26560356_Chip-Seq_TH2_Human1.55416211
54E2F1_18555785_Chip-Seq_ESCs_Mouse1.54636910
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.54310687
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54063893
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53989807
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53321912
59BCAT_22108803_ChIP-Seq_LS180_Human1.53035046
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52626801
61* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51993628
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50664518
63* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50407544
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.50199491
65SCL_19346495_ChIP-Seq_HPC-7_Human1.49843333
66AR_21572438_ChIP-Seq_LNCaP_Human1.49639271
67SUZ12_18555785_Chip-Seq_ESCs_Mouse1.49392808
68GATA1_22025678_ChIP-Seq_K562_Human1.48677574
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48281892
70P53_22387025_ChIP-Seq_ESCs_Mouse1.47710972
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.46782478
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45580751
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45098089
74REST_21632747_ChIP-Seq_MESCs_Mouse1.44977910
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44877589
76STAT3_23295773_ChIP-Seq_U87_Human1.43087746
77RNF2_27304074_Chip-Seq_NSC_Mouse1.42540215
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.41960163
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41879657
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.41524070
81ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40775464
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40509788
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40079471
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.39923284
85P300_18555785_Chip-Seq_ESCs_Mouse1.39871287
86NMYC_18555785_Chip-Seq_ESCs_Mouse1.38688468
87CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38073623
88ER_23166858_ChIP-Seq_MCF-7_Human1.37704198
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.36595598
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36404621
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36111768
92CBP_20019798_ChIP-Seq_JUKART_Human1.36111768
93TCF4_23295773_ChIP-Seq_U87_Human1.36101918
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33329827
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32782199
96IGF1R_20145208_ChIP-Seq_DFB_Human1.32771203
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32705582
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32705582
99TP53_22573176_ChIP-Seq_HFKS_Human1.32539622
100ELK1_19687146_ChIP-ChIP_HELA_Human1.31335098
101IRF8_27001747_Chip-Seq_BMDM_Mouse1.30957407
102* VDR_23849224_ChIP-Seq_CD4+_Human1.30678906
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29236487
104EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.29023422
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.28933647
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.28379309
107RUNX1_27457419_Chip-Seq_LIVER_Mouse1.28314380
108BP1_19119308_ChIP-ChIP_Hs578T_Human1.28273942
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28217667
110AR_25329375_ChIP-Seq_VCAP_Human1.27419787
111SOX2_18555785_Chip-Seq_ESCs_Mouse1.27240881
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26696736
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26581843
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26147233
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25897676
116CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24923383
117FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24458790
118SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.23779215
119PU1_27457419_Chip-Seq_LIVER_Mouse1.23711036
120OCT4_18555785_Chip-Seq_ESCs_Mouse1.23491060
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23439082
122OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22787135
123HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21434667
124MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21002518
125GATA3_27048872_Chip-Seq_THYMUS_Human1.19748847
126NANOG_19829295_ChIP-Seq_ESCs_Human1.18362446
127SOX2_19829295_ChIP-Seq_ESCs_Human1.18362446
128CTCF_18555785_Chip-Seq_ESCs_Mouse1.17887238
129RUNX2_22187159_ChIP-Seq_PCA_Human1.17840307
130RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17365178
131VDR_24787735_ChIP-Seq_THP-1_Human1.17324215
132ZFX_18555785_Chip-Seq_ESCs_Mouse1.16858788
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16185553
134KLF4_18555785_Chip-Seq_ESCs_Mouse1.16054255
135EWS_26573619_Chip-Seq_HEK293_Human1.15826710
136TP53_16413492_ChIP-PET_HCT116_Human1.15691932
137ESRRB_18555785_Chip-Seq_ESCs_Mouse1.14945743
138ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14623922
139TCF4_22108803_ChIP-Seq_LS180_Human1.12989298
140* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12688041
141TAL1_26923725_Chip-Seq_HPCs_Mouse1.12578472
142GABP_17652178_ChIP-ChIP_JURKAT_Human1.12396398
143SMAD1_18555785_Chip-Seq_ESCs_Mouse1.10980770
144FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10515662
145PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10078735
146E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09682593
147MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08885714
148KDM2B_26808549_Chip-Seq_REH_Human1.08860576
149CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08027305
150CDX2_22108803_ChIP-Seq_LS180_Human1.07085997
151SMRT_27268052_Chip-Seq_Bcells_Human1.06649322
152FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05737160
153PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05693168
154ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04525096
155SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03574528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.94714104
2MP0001188_hyperpigmentation3.64986425
3MP0003880_abnormal_central_pattern3.46421397
4MP0003787_abnormal_imprinting3.37770101
5MP0005409_darkened_coat_color2.99947150
6MP0004859_abnormal_synaptic_plasticity2.73708360
7MP0000569_abnormal_digit_pigmentation2.72772786
8MP0003724_increased_susceptibility_to2.65070769
9MP0000015_abnormal_ear_pigmentation2.48716360
10MP0003195_calcinosis2.42462812
11MP0005646_abnormal_pituitary_gland2.33380688
12MP0001486_abnormal_startle_reflex2.29889181
13MP0001800_abnormal_humoral_immune2.22664190
14MP0003635_abnormal_synaptic_transmissio2.18327899
15MP0005174_abnormal_tail_pigmentation2.13265869
16MP0005171_absent_coat_pigmentation2.11973732
17MP0003763_abnormal_thymus_physiology2.11499961
18MP0003136_yellow_coat_color2.07331631
19MP0002166_altered_tumor_susceptibility2.05979869
20MP0009745_abnormal_behavioral_response2.04212889
21MP0005645_abnormal_hypothalamus_physiol2.02163414
22MP0000566_synostosis1.99508340
23MP0005551_abnormal_eye_electrophysiolog1.93196474
24MP0001502_abnormal_circadian_rhythm1.87975005
25MP0002837_dystrophic_cardiac_calcinosis1.87759645
26MP0009046_muscle_twitch1.86014745
27MP0002723_abnormal_immune_serum1.84906865
28MP0003183_abnormal_peptide_metabolism1.83936706
29MP0009785_altered_susceptibility_to1.83112455
30MP0005423_abnormal_somatic_nervous1.80222907
31MP0005000_abnormal_immune_tolerance1.79907119
32MP0002272_abnormal_nervous_system1.78506214
33MP0002452_abnormal_antigen_presenting1.77398599
34MP0008877_abnormal_DNA_methylation1.74006267
35MP0002064_seizures1.72781046
36MP0000685_abnormal_immune_system1.71654321
37MP0002420_abnormal_adaptive_immunity1.71556594
38MP0002638_abnormal_pupillary_reflex1.71329287
39MP0001819_abnormal_immune_cell1.70308754
40MP0001790_abnormal_immune_system1.66296942
41MP0005387_immune_system_phenotype1.66296942
42MP0001968_abnormal_touch/_nociception1.63316620
43MP0002063_abnormal_learning/memory/cond1.62706989
44MP0002148_abnormal_hypersensitivity_rea1.62671745
45MP0002067_abnormal_sensory_capabilities1.62349961
46MP0002572_abnormal_emotion/affect_behav1.58151226
47MP0002009_preneoplasia1.56899011
48MP0002419_abnormal_innate_immunity1.55051947
49MP0004742_abnormal_vestibular_system1.54778272
50MP0001986_abnormal_taste_sensitivity1.53288496
51MP0002006_tumorigenesis1.52799102
52MP0002557_abnormal_social/conspecific_i1.50081112
53MP0005310_abnormal_salivary_gland1.47658012
54MP0005025_abnormal_response_to1.47498461
55MP0003646_muscle_fatigue1.44199443
56MP0000778_abnormal_nervous_system1.43798199
57MP0006082_CNS_inflammation1.41766135
58MP0002095_abnormal_skin_pigmentation1.41362425
59MP0002405_respiratory_system_inflammati1.41291712
60MP0008569_lethality_at_weaning1.40987184
61MP0009764_decreased_sensitivity_to1.40071880
62MP0002876_abnormal_thyroid_physiology1.38972765
63MP0000716_abnormal_immune_system1.37554002
64MP0000689_abnormal_spleen_morphology1.37093746
65MP0003252_abnormal_bile_duct1.36308452
66MP0002398_abnormal_bone_marrow1.35656307
67MP0005253_abnormal_eye_physiology1.34336357
68MP0008875_abnormal_xenobiotic_pharmacok1.34164730
69MP0001501_abnormal_sleep_pattern1.32360699
70MP0008057_abnormal_DNA_replication1.31756500
71MP0004147_increased_porphyrin_level1.31317377
72MP0004270_analgesia1.31186339
73MP0000631_abnormal_neuroendocrine_gland1.30695606
74MP0002734_abnormal_mechanical_nocicepti1.28125359
75MP0006072_abnormal_retinal_apoptosis1.27357225
76MP0003436_decreased_susceptibility_to1.23999175
77MP0003121_genomic_imprinting1.22449340
78MP0000427_abnormal_hair_cycle1.22448945
79MP0002102_abnormal_ear_morphology1.21526027
80MP0001984_abnormal_olfaction1.20913366
81MP0001963_abnormal_hearing_physiology1.18671870
82MP0003656_abnormal_erythrocyte_physiolo1.17964238
83MP0002736_abnormal_nociception_after1.17467014
84MP0005464_abnormal_platelet_physiology1.16883567
85MP0001845_abnormal_inflammatory_respons1.16799691
86MP0003122_maternal_imprinting1.16769679
87MP0001545_abnormal_hematopoietic_system1.14250886
88MP0005397_hematopoietic_system_phenotyp1.14250886
89MP0010386_abnormal_urinary_bladder1.12834251
90MP0001873_stomach_inflammation1.12090807
91MP0003011_delayed_dark_adaptation1.10683800
92MP0004142_abnormal_muscle_tone1.09903553
93MP0003879_abnormal_hair_cell1.09697620
94MP0002722_abnormal_immune_system1.09311750
95MP0009780_abnormal_chondrocyte_physiolo1.08182095
96MP0002396_abnormal_hematopoietic_system1.08180139
97MP0002184_abnormal_innervation1.07507371
98MP0002693_abnormal_pancreas_physiology1.07182482
99MP0002249_abnormal_larynx_morphology1.07141902
100MP0000026_abnormal_inner_ear1.05757919
101MP0002882_abnormal_neuron_morphology1.05059946
102MP0001835_abnormal_antigen_presentation1.04591030
103MP0002138_abnormal_hepatobiliary_system1.04520209
104MP0000372_irregular_coat_pigmentation1.02971550
105MP0003045_fibrosis1.02116549
106MP0008260_abnormal_autophagy1.01165013
107MP0008872_abnormal_physiological_respon1.00788537
108MP0004924_abnormal_behavior1.00030877
109MP0005386_behavior/neurological_phenoty1.00030877
110MP0002928_abnormal_bile_duct0.99757555
111MP0001764_abnormal_homeostasis0.99497324
112MP0002429_abnormal_blood_cell0.98934654
113MP0008469_abnormal_protein_level0.97096673
114MP0005075_abnormal_melanosome_morpholog0.96020392
115MP0010155_abnormal_intestine_physiology0.95377171
116MP0004043_abnormal_pH_regulation0.94807487
117MP0003172_abnormal_lysosome_physiology0.94766524
118MP0001970_abnormal_pain_threshold0.94731816
119MP0002822_catalepsy0.94276293
120MP0006276_abnormal_autonomic_nervous0.93721244
121MP0001440_abnormal_grooming_behavior0.92457893
122MP0004484_altered_response_of0.92401838
123MP0002277_abnormal_respiratory_mucosa0.91963913
124MP0002752_abnormal_somatic_nervous0.91937840
125MP0000681_abnormal_thyroid_gland0.91843568
126MP0000703_abnormal_thymus_morphology0.91464678
127MP0002229_neurodegeneration0.91093627
128MP0002735_abnormal_chemical_nociception0.90173212
129MP0002163_abnormal_gland_morphology0.89846189
130MP0005389_reproductive_system_phenotype0.88341118
131MP0004885_abnormal_endolymph0.87898932
132MP0004381_abnormal_hair_follicle0.87438785
133MP0008961_abnormal_basal_metabolism0.87093499
134MP0005084_abnormal_gallbladder_morpholo0.86743348
135MP0000678_abnormal_parathyroid_gland0.86478076
136MP0002177_abnormal_outer_ear0.86006539
137MP0005671_abnormal_response_to0.85108898
138MP0002733_abnormal_thermal_nociception0.83745958
139MP0000955_abnormal_spinal_cord0.83105688
140MP0001324_abnormal_eye_pigmentation0.81637301
141MP0003690_abnormal_glial_cell0.80803276
142MP0003943_abnormal_hepatobiliary_system0.79173650
143MP0003303_peritoneal_inflammation0.78373047
144MP0001177_atelectasis0.78155289
145MP0001919_abnormal_reproductive_system0.77417918
146MP0005195_abnormal_posterior_eye0.75679775
147MP0003866_abnormal_defecation0.75200944
148MP0005167_abnormal_blood-brain_barrier0.74054929
149MP0008995_early_reproductive_senescence0.73457448
150MP0002066_abnormal_motor_capabilities/c0.73273994
151MP0000465_gastrointestinal_hemorrhage0.72494820
152MP0005379_endocrine/exocrine_gland_phen0.71491291
153MP0000049_abnormal_middle_ear0.71302582
154MP0002075_abnormal_coat/hair_pigmentati0.70703112
155MP0000920_abnormal_myelination0.69627892
156MP0005647_abnormal_sex_gland0.69046682
157MP0001186_pigmentation_phenotype0.67817940
158MP0001485_abnormal_pinna_reflex0.67063459
159MP0004145_abnormal_muscle_electrophysio0.66603905
160MP0003633_abnormal_nervous_system0.64446858
161MP0004811_abnormal_neuron_physiology0.64441239
162MP0000230_abnormal_systemic_arterial0.61535288
163MP0001765_abnormal_ion_homeostasis0.60810688
164MP0003786_premature_aging0.60094767

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.29757070
2Febrile seizures (HP:0002373)4.20363046
3Pancreatic cysts (HP:0001737)3.60663302
4Stomatitis (HP:0010280)3.52417364
5Epileptic encephalopathy (HP:0200134)3.25085811
6Abnormality of the renal cortex (HP:0011035)3.22683593
7Elevated erythrocyte sedimentation rate (HP:0003565)3.15028144
8Renal cortical cysts (HP:0000803)3.05838924
9Abolished electroretinogram (ERG) (HP:0000550)2.93474990
10Decreased central vision (HP:0007663)2.90722602
11Septo-optic dysplasia (HP:0100842)2.90227337
12Dynein arm defect of respiratory motile cilia (HP:0012255)2.87763116
13Absent/shortened dynein arms (HP:0200106)2.87763116
14Abnormal delayed hypersensitivity skin test (HP:0002963)2.87745717
15Recurrent cutaneous fungal infections (HP:0011370)2.85357960
16Chronic mucocutaneous candidiasis (HP:0002728)2.85357960
17Gaze-evoked nystagmus (HP:0000640)2.85279946
18T lymphocytopenia (HP:0005403)2.83584107
19Congenital stationary night blindness (HP:0007642)2.83292633
20Abnormality of T cell number (HP:0011839)2.81840540
21Retrobulbar optic neuritis (HP:0100654)2.80110283
22Optic neuritis (HP:0100653)2.80110283
23Abnormality of the prostate (HP:0008775)2.78665887
24Hypothermia (HP:0002045)2.70852592
25Attenuation of retinal blood vessels (HP:0007843)2.64911676
26Polydipsia (HP:0001959)2.58707573
27Abnormal drinking behavior (HP:0030082)2.58707573
28Broad-based gait (HP:0002136)2.56669058
29Panhypogammaglobulinemia (HP:0003139)2.56574840
30Optic nerve hypoplasia (HP:0000609)2.56137794
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.54396887
32Nephronophthisis (HP:0000090)2.53638811
33Myositis (HP:0100614)2.52726523
34Abnormal rod and cone electroretinograms (HP:0008323)2.50155114
35Thyroiditis (HP:0100646)2.49904321
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49886598
37Congenital sensorineural hearing impairment (HP:0008527)2.47204050
38Abnormality of the renal medulla (HP:0100957)2.46360424
39True hermaphroditism (HP:0010459)2.45757289
40Stomach cancer (HP:0012126)2.44984303
41Large for gestational age (HP:0001520)2.44047452
42Patchy hypopigmentation of hair (HP:0011365)2.43881918
43Protruding tongue (HP:0010808)2.43845341
44Prostate neoplasm (HP:0100787)2.41793515
45Orchitis (HP:0100796)2.41612128
46Nonprogressive disorder (HP:0003680)2.40604732
47Hypoplasia of the fovea (HP:0007750)2.39305064
48Aplasia/Hypoplasia of the fovea (HP:0008060)2.39305064
49Recurrent fungal infections (HP:0002841)2.35111559
50Abnormality of the fovea (HP:0000493)2.34427470
51Severe visual impairment (HP:0001141)2.34131753
52Keratoconus (HP:0000563)2.31913822
53Increased corneal curvature (HP:0100692)2.31913822
54Tubulointerstitial nephritis (HP:0001970)2.31708302
55Focal seizures (HP:0007359)2.31446752
56Abnormality of T cells (HP:0002843)2.30820276
57Generalized hypopigmentation of hair (HP:0011358)2.29575758
58Chromsome breakage (HP:0040012)2.28328151
59White forelock (HP:0002211)2.25464207
60Progressive cerebellar ataxia (HP:0002073)2.23573999
61IgG deficiency (HP:0004315)2.20492778
62Chronic hepatic failure (HP:0100626)2.19910616
63Fair hair (HP:0002286)2.19562429
64Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19174298
65Absent septum pellucidum (HP:0001331)2.16008025
66Encephalitis (HP:0002383)2.15900550
67Chronic otitis media (HP:0000389)2.15560632
68Abnormality of macular pigmentation (HP:0008002)2.15046038
69Bony spicule pigmentary retinopathy (HP:0007737)2.14311578
70Medial flaring of the eyebrow (HP:0010747)2.14103619
71Keratoconjunctivitis (HP:0001096)2.13513134
72Pancreatic fibrosis (HP:0100732)2.10691342
73Scanning speech (HP:0002168)2.10027782
74Action tremor (HP:0002345)2.09846615
75Abnormality of B cell number (HP:0010975)2.08798784
76Bile duct proliferation (HP:0001408)2.06135973
77Abnormal biliary tract physiology (HP:0012439)2.06135973
78Abnormality of the nasal septum (HP:0000419)2.05501285
79Widely spaced teeth (HP:0000687)2.05229149
80Hemoptysis (HP:0002105)2.03272794
81Constricted visual fields (HP:0001133)2.02750498
82Abnormal hair whorl (HP:0010721)2.02299307
83Abnormality of T cell physiology (HP:0011840)2.02014403
84Intestinal atresia (HP:0011100)2.01993345
85Molar tooth sign on MRI (HP:0002419)1.99339847
86Abnormality of midbrain morphology (HP:0002418)1.99339847
87Recurrent skin infections (HP:0001581)1.99286106
88Vasculitis (HP:0002633)1.98223324
89Median cleft lip (HP:0000161)1.97618057
90Dyschromatopsia (HP:0007641)1.97383844
91Gait imbalance (HP:0002141)1.97183176
92Hypokalemic alkalosis (HP:0001949)1.96937773
93Hyperventilation (HP:0002883)1.96870042
94Abnormality of eosinophils (HP:0001879)1.96865368
95Progressive inability to walk (HP:0002505)1.96534669
96Absent speech (HP:0001344)1.96201765
97Recurrent bacterial skin infections (HP:0005406)1.95880503
98Blue irides (HP:0000635)1.95787255
99Polyuria (HP:0000103)1.94667616
100Pulmonary infiltrates (HP:0002113)1.93609430
101Recurrent bronchitis (HP:0002837)1.93527038
102Thyroid-stimulating hormone excess (HP:0002925)1.89324467
103Macular degeneration (HP:0000608)1.88308445
104Dysdiadochokinesis (HP:0002075)1.87886122
105Furrowed tongue (HP:0000221)1.87617966
106Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87357476
107Postaxial foot polydactyly (HP:0001830)1.87335482
108Hypoplastic iliac wings (HP:0002866)1.87121331
109Congenital primary aphakia (HP:0007707)1.86748109
110Central scotoma (HP:0000603)1.86149345
111Cystic liver disease (HP:0006706)1.85390490
112Abnormality of incisor morphology (HP:0011063)1.84690470
113Keratoconjunctivitis sicca (HP:0001097)1.84159079
114Decreased lacrimation (HP:0000633)1.83103524
115Type I transferrin isoform profile (HP:0003642)1.82894067
116Genital tract atresia (HP:0001827)1.82745395
117Abnormal ciliary motility (HP:0012262)1.82725696
118Ketosis (HP:0001946)1.82708506
119Hematochezia (HP:0002573)1.82275485
120Albinism (HP:0001022)1.82034133
121Hypochromic microcytic anemia (HP:0004840)1.81478929
122Neoplasm of the tracheobronchial system (HP:0100552)1.81387363
123Inability to walk (HP:0002540)1.80981195
124Congenital hepatic fibrosis (HP:0002612)1.79795730
125Nephrogenic diabetes insipidus (HP:0009806)1.79610602
126Increased neuronal autofluorescent lipopigment (HP:0002074)1.79465137
127Pustule (HP:0200039)1.78471089
128Excessive salivation (HP:0003781)1.78040008
129Drooling (HP:0002307)1.78040008
130Abnormality of the septum pellucidum (HP:0007375)1.78015380
131Gastrointestinal infarctions (HP:0005244)1.77409351
132Meningitis (HP:0001287)1.77360537
133Alveolar cell carcinoma (HP:0006519)1.77308668
134Atonic seizures (HP:0010819)1.76741813
135Severe combined immunodeficiency (HP:0004430)1.76381944
136Long nose (HP:0003189)1.76306225
137Recurrent abscess formation (HP:0002722)1.76286706
138Abnormality of DNA repair (HP:0003254)1.75766193
139Leukocytosis (HP:0001974)1.75610108
140Metabolic alkalosis (HP:0200114)1.74901497
141Vaginal atresia (HP:0000148)1.74522595
142Poor coordination (HP:0002370)1.74288357
143Arterial thrombosis (HP:0004420)1.74129579
144Agammaglobulinemia (HP:0004432)1.73313555
145Chronic diarrhea (HP:0002028)1.73152097
146Ketoacidosis (HP:0001993)1.72359855
147Abnormality of male internal genitalia (HP:0000022)1.71455180
148Metaphyseal dysplasia (HP:0100255)1.71357085
149Absent frontal sinuses (HP:0002688)1.71186203
150Type II lissencephaly (HP:0007260)1.71038002
151Macroorchidism (HP:0000053)1.65774952
152Alacrima (HP:0000522)1.65365303
153Stage 5 chronic kidney disease (HP:0003774)1.64352753
154Photophobia (HP:0000613)1.64289444
155Hemiparesis (HP:0001269)1.62514410
156Abnormality of salivation (HP:0100755)1.61656739
157Lip pit (HP:0100267)1.61079536
158Aplasia/Hypoplasia of the tongue (HP:0010295)1.60030515
159Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.59738603
160Decreased circulating renin level (HP:0003351)1.59730006
161Aplasia/Hypoplasia of the lens (HP:0008063)1.59413587
162Acute lymphatic leukemia (HP:0006721)1.58246016
163Preaxial hand polydactyly (HP:0001177)1.57267455
164Growth hormone deficiency (HP:0000824)1.57174566
165Astigmatism (HP:0000483)1.57037578
166Tented upper lip vermilion (HP:0010804)1.56903354
167Renal dysplasia (HP:0000110)1.56810853
168Inappropriate behavior (HP:0000719)1.56699324
169Aplasia cutis congenita (HP:0001057)1.55285057
170Midline defect of the nose (HP:0004122)1.52264891
171Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.51672086
172Cortical visual impairment (HP:0100704)1.50404926

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.30851173
2CASK4.48161218
3TNIK4.39944303
4NEK63.17274518
5TAOK33.10748693
6MAP2K72.56878505
7NTRK32.54292946
8MUSK2.45197169
9EPHA42.39134096
10MAP4K22.31461484
11PRPF4B2.30336106
12MKNK22.17460018
13INSRR2.14202554
14MAPK131.90470875
15TXK1.82528266
16YES11.80741505
17FES1.69836093
18IRAK41.69476859
19SGK21.66661089
20BMPR1B1.61414433
21ACVR1B1.60668090
22BLK1.57258594
23CDK31.56500279
24MAP3K141.47992714
25MAP4K11.45843606
26EIF2AK31.42387509
27SYK1.40141480
28MKNK11.36099539
29TLK11.31920774
30MARK11.30916966
31ITK1.30640299
32ZAK1.27718214
33MST41.25101273
34TNK21.24591844
35ADRBK21.23860381
36AKT31.22512900
37SGK2231.21160590
38SGK4941.21160590
39NUAK11.18127880
40ERBB31.16973549
41CLK11.08465680
42CAMKK21.07307023
43NTRK21.06085640
44PIK3CG1.05541450
45PRKCQ1.05077601
46IRAK21.04846286
47TRIM281.03022727
48SGK31.02944700
49TYK21.02818158
50SIK21.00692591
51IRAK11.00495699
52BMPR21.00120843
53BCKDK0.99737824
54DAPK20.99719458
55JAK10.99636083
56IRAK30.99546157
57BRSK20.99097959
58TRPM70.98840361
59PDK20.98035228
60PIK3CA0.97645410
61CAMK1G0.97411089
62NLK0.96536703
63CAMK10.95825718
64STK160.94584737
65MAP3K130.93441724
66LCK0.92349705
67BRD40.92044001
68STK380.90998835
69MARK30.90922004
70FGR0.89885802
71RIPK40.85757395
72KIT0.84775151
73MAPK150.84057820
74PINK10.82006894
75FLT30.81732496
76EPHA30.81692603
77PAK30.81457196
78DYRK1A0.81022433
79TAOK20.80254152
80MAP2K60.80058967
81TEC0.79567996
82RPS6KA40.78665606
83GRK10.78298404
84MAPK70.78037447
85GRK60.77539129
86GRK70.75944649
87ADRBK10.75357338
88CAMK1D0.75209678
89MATK0.74293926
90STK390.72939418
91MAP3K40.72505260
92IKBKE0.72059729
93CCNB10.70263027
94PKN10.70163800
95SGK10.69903530
96CSK0.68784340
97EIF2AK20.68157582
98SRPK10.67656319
99ZAP700.65914335
100CSF1R0.65215333
101WNK40.65056442
102MAP3K70.64863185
103CDK50.62609080
104TGFBR20.61124922
105HIPK20.61018080
106PRKCE0.61002367
107PRKCH0.59133907
108PTK2B0.57673722
109UHMK10.57467521
110JAK20.55737054
111FGFR30.54889787
112CAMKK10.54456282
113IKBKB0.54211065
114JAK30.53922510
115CDK190.52306229
116CAMK2A0.51947370
117FGFR20.51635955
118ABL10.49352301
119VRK10.49258197
120CAMK40.49132089
121CHUK0.48978650
122STK30.47935651
123OXSR10.47486355
124PRKD20.45746181
125PRKAA20.45438040
126STK38L0.45229692
127WNK10.45202904
128PRKG10.44623408
129LYN0.44130185
130PIM10.43382767
131SIK30.43073206
132TGFBR10.43053342
133PDK10.42502777
134WNK30.41563524
135RPS6KB10.40982778
136CAMK2B0.40603366
137PASK0.40064716
138CDK90.39937455
139HCK0.39670982
140TBK10.39644368
141FER0.39430191
142MAPK120.39066659
143BTK0.38599278
144PLK20.38465584
145CDC42BPA0.38463977
146IGF1R0.38293452
147STK110.38293039
148MARK20.37744935
149PDGFRB0.37356268
150DYRK1B0.37312047
151TIE10.36955370
152DMPK0.36512102

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.01830159
2Morphine addiction_Homo sapiens_hsa050322.45128454
3Phototransduction_Homo sapiens_hsa047442.35936484
4Linoleic acid metabolism_Homo sapiens_hsa005912.22983173
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.22592271
6Glutamatergic synapse_Homo sapiens_hsa047242.21016800
7Circadian entrainment_Homo sapiens_hsa047132.18041306
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.14285415
9Caffeine metabolism_Homo sapiens_hsa002322.11207017
10GABAergic synapse_Homo sapiens_hsa047272.06504811
11Olfactory transduction_Homo sapiens_hsa047401.94549554
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85811585
13Taste transduction_Homo sapiens_hsa047421.82151053
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75070339
15Regulation of autophagy_Homo sapiens_hsa041401.69208397
16Serotonergic synapse_Homo sapiens_hsa047261.66099323
17Nitrogen metabolism_Homo sapiens_hsa009101.65245551
18Synaptic vesicle cycle_Homo sapiens_hsa047211.63919847
19Leishmaniasis_Homo sapiens_hsa051401.62481509
20Insulin secretion_Homo sapiens_hsa049111.58893022
21Protein export_Homo sapiens_hsa030601.57350226
22Salivary secretion_Homo sapiens_hsa049701.51955589
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49087518
24Cholinergic synapse_Homo sapiens_hsa047251.48932874
25Staphylococcus aureus infection_Homo sapiens_hsa051501.44179786
26Calcium signaling pathway_Homo sapiens_hsa040201.37853860
27Antigen processing and presentation_Homo sapiens_hsa046121.36710476
28Butanoate metabolism_Homo sapiens_hsa006501.35524602
29Dorso-ventral axis formation_Homo sapiens_hsa043201.34551677
30Amphetamine addiction_Homo sapiens_hsa050311.27262458
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27089206
32Dopaminergic synapse_Homo sapiens_hsa047281.26621604
33Long-term depression_Homo sapiens_hsa047301.24808146
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23386768
35T cell receptor signaling pathway_Homo sapiens_hsa046601.22931026
36Renin secretion_Homo sapiens_hsa049241.18763433
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17883810
38cAMP signaling pathway_Homo sapiens_hsa040241.15501123
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14782578
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14624371
41Axon guidance_Homo sapiens_hsa043601.13481419
42Tuberculosis_Homo sapiens_hsa051521.12882794
43Basal transcription factors_Homo sapiens_hsa030221.12851551
44Circadian rhythm_Homo sapiens_hsa047101.12745879
45Cocaine addiction_Homo sapiens_hsa050301.11973586
46Long-term potentiation_Homo sapiens_hsa047201.10056544
47Tryptophan metabolism_Homo sapiens_hsa003801.05387418
48Sphingolipid metabolism_Homo sapiens_hsa006001.04309260
49Type II diabetes mellitus_Homo sapiens_hsa049301.04225951
50Oxytocin signaling pathway_Homo sapiens_hsa049211.03783706
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02650546
52Other glycan degradation_Homo sapiens_hsa005111.02249372
53Fanconi anemia pathway_Homo sapiens_hsa034600.98968879
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97287670
55Gastric acid secretion_Homo sapiens_hsa049710.91390307
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90313551
57Chemokine signaling pathway_Homo sapiens_hsa040620.90229272
58Propanoate metabolism_Homo sapiens_hsa006400.89015303
59RNA degradation_Homo sapiens_hsa030180.88792811
60Herpes simplex infection_Homo sapiens_hsa051680.87643900
61Ovarian steroidogenesis_Homo sapiens_hsa049130.86669554
62Peroxisome_Homo sapiens_hsa041460.85752615
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.83952147
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82733792
65Legionellosis_Homo sapiens_hsa051340.82226007
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82093140
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.81214406
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80943754
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80350288
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79966710
71Rheumatoid arthritis_Homo sapiens_hsa053230.79445655
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79027152
73Ras signaling pathway_Homo sapiens_hsa040140.78991986
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77912572
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77173764
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76991327
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76903453
78Inositol phosphate metabolism_Homo sapiens_hsa005620.76872779
79Hematopoietic cell lineage_Homo sapiens_hsa046400.76121833
80Type I diabetes mellitus_Homo sapiens_hsa049400.75889886
81Autoimmune thyroid disease_Homo sapiens_hsa053200.74764564
82ErbB signaling pathway_Homo sapiens_hsa040120.74689169
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74345132
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73922852
85Ether lipid metabolism_Homo sapiens_hsa005650.73832746
86MAPK signaling pathway_Homo sapiens_hsa040100.73707870
87African trypanosomiasis_Homo sapiens_hsa051430.73434627
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.72314096
89Homologous recombination_Homo sapiens_hsa034400.71750514
90GnRH signaling pathway_Homo sapiens_hsa049120.71631555
91Measles_Homo sapiens_hsa051620.68675420
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.68577876
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68274254
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67291830
95Pancreatic secretion_Homo sapiens_hsa049720.66926745
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.66539059
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66066422
98Graft-versus-host disease_Homo sapiens_hsa053320.65759438
99Wnt signaling pathway_Homo sapiens_hsa043100.65287392
100Choline metabolism in cancer_Homo sapiens_hsa052310.65076047
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64837429
102Mineral absorption_Homo sapiens_hsa049780.63588661
103Allograft rejection_Homo sapiens_hsa053300.62898461
104Melanogenesis_Homo sapiens_hsa049160.61492500
105Platelet activation_Homo sapiens_hsa046110.61420070
106Osteoclast differentiation_Homo sapiens_hsa043800.60525285
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60214718
108Toxoplasmosis_Homo sapiens_hsa051450.59880906
109Collecting duct acid secretion_Homo sapiens_hsa049660.59786187
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59121697
111Primary immunodeficiency_Homo sapiens_hsa053400.58820872
112Glycerolipid metabolism_Homo sapiens_hsa005610.58617978
113Non-homologous end-joining_Homo sapiens_hsa034500.57959751
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57628597
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56098338
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.55070537
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.54047077
118Rap1 signaling pathway_Homo sapiens_hsa040150.53873860
119Lysosome_Homo sapiens_hsa041420.53339068
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.52850285
121ABC transporters_Homo sapiens_hsa020100.52751625
122Influenza A_Homo sapiens_hsa051640.52732256
123TNF signaling pathway_Homo sapiens_hsa046680.51785080
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50823198
125N-Glycan biosynthesis_Homo sapiens_hsa005100.49026218
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48922384
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.48798621
128B cell receptor signaling pathway_Homo sapiens_hsa046620.48305111
129Asthma_Homo sapiens_hsa053100.48041702
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47663291
131Arachidonic acid metabolism_Homo sapiens_hsa005900.47634824
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46823807
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46740359
134Malaria_Homo sapiens_hsa051440.46189057
135Selenocompound metabolism_Homo sapiens_hsa004500.44329899
136Chemical carcinogenesis_Homo sapiens_hsa052040.42452796
137Phagosome_Homo sapiens_hsa041450.36605323
138Viral myocarditis_Homo sapiens_hsa054160.35806036
139FoxO signaling pathway_Homo sapiens_hsa040680.35632315
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33383136
141Retinol metabolism_Homo sapiens_hsa008300.31747612

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