ZMYND10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome assembly (GO:0001675)9.91018333
2multicellular organism reproduction (GO:0032504)9.62798259
3binding of sperm to zona pellucida (GO:0007339)9.48707098
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.47286268
5cell wall macromolecule catabolic process (GO:0016998)9.31335218
6cell wall macromolecule metabolic process (GO:0044036)9.31335218
7cell-cell recognition (GO:0009988)9.11266603
8spermatid development (GO:0007286)9.07788453
9plasma membrane fusion (GO:0045026)9.05788606
10male meiosis (GO:0007140)8.67643630
11regulation of cilium movement (GO:0003352)8.44004044
12synaptonemal complex organization (GO:0070193)8.15702949
13reproduction (GO:0000003)7.98331207
14* motile cilium assembly (GO:0044458)7.95914966
15synaptonemal complex assembly (GO:0007130)7.59544477
16primary alcohol catabolic process (GO:0034310)6.88465246
17negative regulation of inclusion body assembly (GO:0090084)6.82516226
18single fertilization (GO:0007338)6.81702394
19DNA methylation involved in gamete generation (GO:0043046)6.62477919
20male meiosis I (GO:0007141)6.48091338
21sperm capacitation (GO:0048240)6.10405436
22vitamin transmembrane transport (GO:0035461)6.10357093
23spermatogenesis (GO:0007283)6.07734918
24male gamete generation (GO:0048232)6.05398842
25fertilization (GO:0009566)6.03411228
26organic cation transport (GO:0015695)5.99495612
27ventricular system development (GO:0021591)5.99271067
28ethanol metabolic process (GO:0006067)5.87753388
29diterpenoid biosynthetic process (GO:0016102)5.58336796
30gamete generation (GO:0007276)5.58098694
31regulation of inclusion body assembly (GO:0090083)5.38300078
32chromosome organization involved in meiosis (GO:0070192)5.31519530
33meiosis I (GO:0007127)5.26402395
34meiotic nuclear division (GO:0007126)5.26225342
35microtubule depolymerization (GO:0007019)5.22408879
36germ cell development (GO:0007281)5.21879291
37cellular process involved in reproduction in multicellular organism (GO:0022412)5.11644723
38axoneme assembly (GO:0035082)5.08473360
39microtubule severing (GO:0051013)5.07858239
40regulation of microtubule-based movement (GO:0060632)5.07574673
41lung epithelium development (GO:0060428)5.02673966
42pyrimidine-containing compound transmembrane transport (GO:0072531)5.02341706
43tolerance induction (GO:0002507)5.01994082
44protein localization to cilium (GO:0061512)4.95246594
45meiotic cell cycle (GO:0051321)4.92496008
46one-carbon compound transport (GO:0019755)4.91625637
47glomerular epithelial cell development (GO:0072310)4.86896279
48negative regulation of T cell differentiation in thymus (GO:0033085)4.82758758
49seminiferous tubule development (GO:0072520)4.69782550
50response to xenobiotic stimulus (GO:0009410)4.64994115
51left/right pattern formation (GO:0060972)4.64820913
52calcium ion-dependent exocytosis (GO:0017156)4.60674710
53establishment of apical/basal cell polarity (GO:0035089)4.50981528
54ethanol oxidation (GO:0006069)4.49456349
55negative regulation of B cell mediated immunity (GO:0002713)4.47078844
56negative regulation of immunoglobulin mediated immune response (GO:0002890)4.47078844
57cell recognition (GO:0008037)4.46813360
58intraciliary transport (GO:0042073)4.40168243
59multicellular organismal reproductive process (GO:0048609)4.37992240
60* cell projection assembly (GO:0030031)4.35995687
61regulation of interleukin-5 production (GO:0032674)4.14660974
62negative regulation of humoral immune response (GO:0002921)4.10107521
63positive regulation of tolerance induction (GO:0002645)4.02544698
64establishment or maintenance of monopolar cell polarity (GO:0061339)4.00210636
65establishment of monopolar cell polarity (GO:0061162)4.00210636
66negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.98916278
67protein polyglutamylation (GO:0018095)3.98402907
68terpenoid biosynthetic process (GO:0016114)3.94112419
69regulation of germinal center formation (GO:0002634)3.92026130
70retinoic acid metabolic process (GO:0042573)3.89464533
71gene silencing by RNA (GO:0031047)3.88934173
72regulation of interleukin-13 production (GO:0032656)3.75669446
73genitalia morphogenesis (GO:0035112)3.73631192
74cilium morphogenesis (GO:0060271)3.71303722
75spermatid nucleus differentiation (GO:0007289)3.70416651
76microtubule-based movement (GO:0007018)3.70100047
77nucleoside diphosphate phosphorylation (GO:0006165)3.67532881
78chromosome condensation (GO:0030261)3.63538735
79cytoplasmic microtubule organization (GO:0031122)3.61652003
80carnitine transport (GO:0015879)3.58582919
81amino-acid betaine transport (GO:0015838)3.58582919
82chaperone-mediated protein complex assembly (GO:0051131)3.57220452
83* cilium organization (GO:0044782)3.56290884
84DNA packaging (GO:0006323)3.54865248
85regulation of meiosis I (GO:0060631)3.52559809
86multicellular organismal development (GO:0007275)3.46983069
87centriole assembly (GO:0098534)3.41202522
88establishment of tissue polarity (GO:0007164)3.39370402
89establishment of planar polarity (GO:0001736)3.39370402
90* cilium assembly (GO:0042384)3.36854207
91protein refolding (GO:0042026)3.36266395
92carnitine transmembrane transport (GO:1902603)3.35756346
93lateral ventricle development (GO:0021670)3.35694713
94meiotic cell cycle process (GO:1903046)3.34057822
95glycerol ether metabolic process (GO:0006662)3.31855793
96determination of left/right symmetry (GO:0007368)3.31495710
97exogenous drug catabolic process (GO:0042738)3.30017622
98smoothened signaling pathway (GO:0007224)3.27878150
99retinol metabolic process (GO:0042572)3.21344021
100GTP biosynthetic process (GO:0006183)3.20732294
101primary alcohol metabolic process (GO:0034308)3.19913508
102glutathione derivative biosynthetic process (GO:1901687)3.18699086
103glutathione derivative metabolic process (GO:1901685)3.18699086
104determination of bilateral symmetry (GO:0009855)3.17458563
105* cellular component assembly involved in morphogenesis (GO:0010927)3.16145938
106alditol metabolic process (GO:0019400)3.13485128
107negative regulation of organelle assembly (GO:1902116)3.13166225
108specification of symmetry (GO:0009799)3.11018355
109polyol catabolic process (GO:0046174)3.08798284
110synapsis (GO:0007129)3.07057549
111positive regulation of smoothened signaling pathway (GO:0045880)3.05339192
112ether metabolic process (GO:0018904)3.05142436
113centriole replication (GO:0007099)3.04369652
114left/right axis specification (GO:0070986)3.03887482
115lateral sprouting from an epithelium (GO:0060601)3.03452277
116monoubiquitinated protein deubiquitination (GO:0035520)3.02461785
117lactate metabolic process (GO:0006089)2.99591523
118regulation of spindle checkpoint (GO:0090231)2.97735214
119microtubule-based process (GO:0007017)2.95427040
120regulation of tolerance induction (GO:0002643)2.94493982
121hydrogen peroxide biosynthetic process (GO:0050665)2.92380569
122O-glycan processing (GO:0016266)2.84561844
123regulation of autophagic vacuole assembly (GO:2000785)2.82236960
124UTP biosynthetic process (GO:0006228)2.81531132
125glycerol metabolic process (GO:0006071)2.79719085
126regulation of centriole replication (GO:0046599)2.79648414
127quaternary ammonium group transport (GO:0015697)2.78572323
128phosphatidylethanolamine biosynthetic process (GO:0006646)2.75548214
129gene silencing (GO:0016458)2.75430182
130microtubule bundle formation (GO:0001578)2.74737225
131regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.74318982
132* organelle assembly (GO:0070925)2.72905193
133nonmotile primary cilium assembly (GO:0035058)2.71886632
134peptidyl-glutamic acid modification (GO:0018200)2.71017472
135aldehyde catabolic process (GO:0046185)2.69859906
136microtubule polymerization or depolymerization (GO:0031109)2.67715281
137regulation of microtubule depolymerization (GO:0031114)2.65957223
138glycolytic process (GO:0006096)2.65678394
139sex differentiation (GO:0007548)2.64906977
140carnitine metabolic process (GO:0009437)2.64826279
141regulation of protein polyubiquitination (GO:1902914)2.63543275
142nucleus organization (GO:0006997)2.62700955
143phosphatidylcholine biosynthetic process (GO:0006656)2.62594287
144mitotic sister chromatid cohesion (GO:0007064)2.62122222
145UTP metabolic process (GO:0046051)2.62121070
146heart looping (GO:0001947)2.59539247
147reactive oxygen species biosynthetic process (GO:1903409)2.58476840
148drug catabolic process (GO:0042737)2.57494686
149phosphatidylethanolamine metabolic process (GO:0046337)2.57423833
150retinal rod cell development (GO:0046548)2.56328060
151excretion (GO:0007588)2.54303205
152phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.53187456
153oligosaccharide biosynthetic process (GO:0009312)2.52779130
154apical protein localization (GO:0045176)2.50659871
155multicellular organismal water homeostasis (GO:0050891)2.50367866
156regulation of smoothened signaling pathway (GO:0008589)2.48335361
157regulation of vacuole organization (GO:0044088)2.41912986
158embryonic heart tube morphogenesis (GO:0003143)2.39090989
159mitochondrion degradation (GO:0000422)2.36397969
160photoreceptor cell maintenance (GO:0045494)2.35303767
161cilium or flagellum-dependent cell motility (GO:0001539)14.6278944
162fusion of sperm to egg plasma membrane (GO:0007342)11.8955739
163sperm motility (GO:0030317)11.7777060
164* axonemal dynein complex assembly (GO:0070286)11.4908286
165epithelial cilium movement (GO:0003351)10.6706919
166piRNA metabolic process (GO:0034587)10.4618003
167acrosome reaction (GO:0007340)10.2207095
168sperm-egg recognition (GO:0035036)10.2170656
169cilium movement (GO:0003341)10.0780773

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.29405173
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.05057807
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.01843453
4DROSHA_22980978_ChIP-Seq_HELA_Human3.36745047
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.00858665
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.61420720
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.45396430
8GATA1_26923725_Chip-Seq_HPCs_Mouse2.28480055
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16487296
10* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.14616095
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.10596449
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.09346852
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07219322
14ELK4_26923725_Chip-Seq_MESODERM_Mouse2.01574322
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.6584703
16ZNF274_21170338_ChIP-Seq_K562_Hela1.97356880
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94043405
18VDR_22108803_ChIP-Seq_LS180_Human1.90096963
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86481845
20SMC4_20622854_ChIP-Seq_HELA_Human1.86311181
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.85498519
22STAT1_20625510_ChIP-Seq_HELA_Human1.84938038
23AHR_22903824_ChIP-Seq_MCF-7_Human1.84859209
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.79167325
25RUNX1_27514584_Chip-Seq_MCF-7_Human1.73075879
26WDR5_24793694_ChIP-Seq_LNCAP_Human1.67823842
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.66379803
28FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.61831128
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61734748
30FOXM1_26456572_ChIP-Seq_MCF-7_Human1.55353943
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.55258146
32STAT1_17558387_ChIP-Seq_HELA_Human1.54503389
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.52754698
34NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52720628
35FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51926724
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51634591
37TP63_23658742_ChIP-Seq_EP156T_Human1.51175807
38MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49547436
39KAP1_22055183_ChIP-Seq_ESCs_Mouse1.48875247
40TP63_22573176_ChIP-Seq_HFKS_Human1.46917714
41ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46862409
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.45637085
43TP53_18474530_ChIP-ChIP_U2OS_Human1.44442492
44SOX2_22085726_ChIP-Seq_NPCs_Mouse1.43254649
45ETV1_20927104_ChIP-Seq_GIST48_Human1.43121272
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42372351
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.41196979
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.41163756
49PHF8_20622853_ChIP-Seq_HELA_Human1.39622504
50GATA3_21867929_ChIP-Seq_CD8_Mouse1.38656709
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37888784
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.37062830
53CTCF_27219007_Chip-Seq_Bcells_Human1.36702952
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36161813
55AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.36156042
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35156053
57CBP_20019798_ChIP-Seq_JUKART_Human1.35156053
58KLF5_25053715_ChIP-Seq_YYC3_Human1.34867583
59GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.34720098
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.34404576
61HNFA_21074721_ChIP-Seq_CACO-2_Human1.34403813
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34139850
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.33996469
64REST_21632747_ChIP-Seq_MESCs_Mouse1.33862105
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32727986
66PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.31968473
67* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31819207
68P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28523096
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27696638
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27696638
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.26197009
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25998588
73SMRT_27268052_Chip-Seq_Bcells_Human1.25914484
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25821561
75* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23826904
76KDM2B_26808549_Chip-Seq_REH_Human1.23319651
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23266564
78PHF8_20622854_ChIP-Seq_HELA_Human1.23190000
79LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.23040830
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22807761
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.22684328
82RBPJ_21746931_ChIP-Seq_IB4_Human1.21651461
83P68_20966046_ChIP-Seq_HELA_Human1.20524983
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20242464
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.19186377
86* CTCF_20526341_ChIP-Seq_ESCs_Human1.19055139
87FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17150120
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16426373
89P53_21459846_ChIP-Seq_SAOS-2_Human1.15974721
90SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15153943
91CBX2_22325352_ChIP-Seq_293T-Rex_Human1.14989581
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.14946693
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14612024
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14592396
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13726397
96RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12443534
97* FOXA1_25552417_ChIP-Seq_VCAP_Human1.12408993
98GATA6_21074721_ChIP-Seq_CACO-2_Human1.11633706
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11595316
100AR_21572438_ChIP-Seq_LNCaP_Human1.11526871
101NFYA_21822215_ChIP-Seq_K562_Human1.11484947
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11187259
103GF1_26923725_Chip-Seq_HPCs_Mouse1.10167017
104GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.09029605
105CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08781742
106RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08686760
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07581462
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07172953
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07130394
110P300_27268052_Chip-Seq_Bcells_Human1.06809300
111PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05704292
112CEBPB_22108803_ChIP-Seq_LS180_Human1.05149985
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05090091
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04888653
115SMAD4_21799915_ChIP-Seq_A2780_Human1.04557070
116VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04013251
117RNF2_27304074_Chip-Seq_NSC_Mouse1.03786836
118GATA3_21867929_ChIP-Seq_TH1_Mouse1.03705483
119SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03646372
120E2F1_20622854_ChIP-Seq_HELA_Human1.03380103
121CRX_20693478_ChIP-Seq_RETINA_Mouse1.02471373
122ERG_20517297_ChIP-Seq_VCAP_Human1.02402227
123CDX2_20551321_ChIP-Seq_CACO-2_Human1.02124282
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01882109
125SOX2_20726797_ChIP-Seq_SW620_Human1.01674615
126CBX2_27304074_Chip-Seq_ESCs_Mouse1.01546880
127MYC_27129775_Chip-Seq_CORNEA_Mouse1.01269179
128GATA1_19941826_ChIP-Seq_K562_Human1.01128590
129OCT4_20526341_ChIP-Seq_ESCs_Human0.98772744
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98388560
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96887248
132PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96470418
133* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96424088
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96025995
135EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95880349
136CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95530538
137NANOG_18555785_Chip-Seq_ESCs_Mouse0.94587300
138RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94381494
139TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94362685
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.93897862
141OCT4_18555785_Chip-Seq_ESCs_Mouse0.93421802
142MYC_19829295_ChIP-Seq_ESCs_Human0.93356863
143OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93309284
144GATA4_25053715_ChIP-Seq_YYC3_Human0.92955597
145TCF4_22108803_ChIP-Seq_LS180_Human0.92441739
146ESET_19884257_ChIP-Seq_ESCs_Mouse0.91544936
147GF1B_26923725_Chip-Seq_HPCs_Mouse0.91534442
148SPI1_26923725_Chip-Seq_HPCs_Mouse0.91026645
149RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90798419
150RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90630887
151ERA_21632823_ChIP-Seq_H3396_Human0.90602451
152MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90235978
153* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90071073
154SMAD4_21741376_ChIP-Seq_EPCs_Human0.89986219
155FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89962789
156FOXA1_25329375_ChIP-Seq_VCAP_Human0.89962789
157CREB1_26743006_Chip-Seq_LNCaP_Human0.89554572
158RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89473669
159ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88539879
160CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87879759
161P53_22387025_ChIP-Seq_ESCs_Mouse0.87515490
162FLI1_21867929_ChIP-Seq_CD8_Mouse0.87204621
163EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86810353
164BCAT_22108803_ChIP-Seq_LS180_Human0.86647424
165EZH2_27294783_Chip-Seq_NPCs_Mouse0.86533944
166YY1_22570637_ChIP-Seq_MALME-3M_Human0.86187968
167* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86164006
168NFYB_21822215_ChIP-Seq_K562_Human0.86134182
169TBL1_22424771_ChIP-Seq_293T_Human0.85618888
170KLF4_18555785_Chip-Seq_ESCs_Mouse0.84832950
171GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84314587
172OCT1_27270436_Chip-Seq_PROSTATE_Human0.83453123
173TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82858161
174ELF1_20517297_ChIP-Seq_JURKAT_Human0.82391738
175* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82355447
176TCF4_23295773_ChIP-Seq_U87_Human0.82265551
177P300_18555785_Chip-Seq_ESCs_Mouse0.81876416
178SMAD3_21741376_ChIP-Seq_ESCs_Human0.81866831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.87269949
2MP0001929_abnormal_gametogenesis5.50500027
3MP0008877_abnormal_DNA_methylation4.96565194
4MP0002210_abnormal_sex_determination3.75063500
5MP0002653_abnormal_ependyma_morphology3.73698149
6MP0000566_synostosis3.66688403
7MP0002277_abnormal_respiratory_mucosa3.50338279
8MP0008789_abnormal_olfactory_epithelium3.48358288
9MP0002161_abnormal_fertility/fecundity3.22007030
10MP0001145_abnormal_male_reproductive3.16914374
11MP0009780_abnormal_chondrocyte_physiolo3.11755414
12MP0000653_abnormal_sex_gland2.77074828
13MP0005499_abnormal_olfactory_system2.47244370
14MP0005394_taste/olfaction_phenotype2.47244370
15MP0002160_abnormal_reproductive_system2.29190008
16MP0005670_abnormal_white_adipose2.16051766
17MP0001984_abnormal_olfaction2.02904439
18MP0005410_abnormal_fertilization14.7410321
19MP0005623_abnormal_meninges_morphology1.88136989
20MP0000383_abnormal_hair_follicle1.86485439
21MP0005083_abnormal_biliary_tract1.78318318
22MP0003646_muscle_fatigue1.69826785
23MP0002249_abnormal_larynx_morphology1.63896603
24MP0003656_abnormal_erythrocyte_physiolo1.59066832
25MP0010678_abnormal_skin_adnexa1.52842185
26MP0010030_abnormal_orbit_morphology1.45380821
27MP0000678_abnormal_parathyroid_gland1.41683409
28MP0001346_abnormal_lacrimal_gland1.40584994
29MP0001765_abnormal_ion_homeostasis1.38608183
30MP0002909_abnormal_adrenal_gland1.38317916
31MP0002638_abnormal_pupillary_reflex1.38286158
32MP0008995_early_reproductive_senescence1.38113691
33MP0002282_abnormal_trachea_morphology1.37857611
34MP0008057_abnormal_DNA_replication1.37333977
35MP0009379_abnormal_foot_pigmentation1.37053630
36MP0002734_abnormal_mechanical_nocicepti1.30261033
37MP0005248_abnormal_Harderian_gland1.27560436
38MP0009046_muscle_twitch1.20221842
39MP0004233_abnormal_muscle_weight1.17597098
40MP0001485_abnormal_pinna_reflex1.12274564
41MP0005389_reproductive_system_phenotype1.10971210
42MP0002233_abnormal_nose_morphology1.10969267
43MP0005395_other_phenotype1.10897617
44MP0003878_abnormal_ear_physiology1.08691375
45MP0005377_hearing/vestibular/ear_phenot1.08691375
46MP0005647_abnormal_sex_gland1.08209735
47MP0000026_abnormal_inner_ear1.03377500
48MP0002735_abnormal_chemical_nociception0.96354963
49MP0002234_abnormal_pharynx_morphology0.94568275
50MP0005165_increased_susceptibility_to0.91826210
51MP0002928_abnormal_bile_duct0.89599553
52MP0008058_abnormal_DNA_repair0.89319893
53MP0003011_delayed_dark_adaptation0.88835835
54MP0002876_abnormal_thyroid_physiology0.85853872
55MP0005408_hypopigmentation0.83899356
56MP0000465_gastrointestinal_hemorrhage0.81776267
57MP0010094_abnormal_chromosome_stability0.80703332
58MP0010155_abnormal_intestine_physiology0.80455164
59MP0005636_abnormal_mineral_homeostasis0.79991401
60MP0005365_abnormal_bile_salt0.78657509
61MP0003786_premature_aging0.78278244
62MP0003115_abnormal_respiratory_system0.74555213
63MP0002102_abnormal_ear_morphology0.72728766
64MP0004043_abnormal_pH_regulation0.72469355
65MP0004883_abnormal_blood_vessel0.70344602
66MP0004019_abnormal_vitamin_homeostasis0.69806374
67MP0004885_abnormal_endolymph0.68880612
68MP0003938_abnormal_ear_development0.68143732
69MP0000358_abnormal_cell_content/0.68128314
70MP0001970_abnormal_pain_threshold0.67678782
71MP0000681_abnormal_thyroid_gland0.66933364
72MP0005164_abnormal_response_to0.66803526
73MP0001963_abnormal_hearing_physiology0.66784042
74MP0000467_abnormal_esophagus_morphology0.66758540
75MP0005503_abnormal_tendon_morphology0.66703247
76MP0001270_distended_abdomen0.66059459
77MP0000631_abnormal_neuroendocrine_gland0.65955708
78MP0001502_abnormal_circadian_rhythm0.65346401
79MP0001849_ear_inflammation0.64871197
80MP0002822_catalepsy0.64293832
81MP0005085_abnormal_gallbladder_physiolo0.63947039
82MP0009765_abnormal_xenobiotic_induced0.63374183
83MP0003329_amyloid_beta_deposits0.63048880
84MP0000049_abnormal_middle_ear0.61206368
85MP0001188_hyperpigmentation0.60906361
86MP0004133_heterotaxia0.60480558
87MP0010234_abnormal_vibrissa_follicle0.60184041
88MP0004264_abnormal_extraembryonic_tissu0.59460548
89MP0002098_abnormal_vibrissa_morphology0.59341429
90MP0001664_abnormal_digestion0.57962127
91MP0001293_anophthalmia0.57548247
92MP0005397_hematopoietic_system_phenotyp0.56479766
93MP0001545_abnormal_hematopoietic_system0.56479766
94MP0003937_abnormal_limbs/digits/tail_de0.55541634
95MP0005310_abnormal_salivary_gland0.55494553
96MP0003879_abnormal_hair_cell0.54375719
97MP0005220_abnormal_exocrine_pancreas0.53738848
98MP0002116_abnormal_craniofacial_bone0.53180567
99MP0008875_abnormal_xenobiotic_pharmacok0.52490279
100MP0001299_abnormal_eye_distance/0.52451690
101MP0003806_abnormal_nucleotide_metabolis0.51598389
102MP0001661_extended_life_span0.50260456
103MP0008961_abnormal_basal_metabolism0.50103910
104MP0004808_abnormal_hematopoietic_stem0.49548535
105MP0000955_abnormal_spinal_cord0.49485712
106MP0005360_urolithiasis0.49395105
107MP0003699_abnormal_female_reproductive0.49012249
108MP0001944_abnormal_pancreas_morphology0.48125259
109MP0005409_darkened_coat_color0.47768679
110MP0009703_decreased_birth_body0.47272275
111MP0008004_abnormal_stomach_pH0.46807434
112MP0005666_abnormal_adipose_tissue0.46485410
113MP0002405_respiratory_system_inflammati0.45926950
114MP0005551_abnormal_eye_electrophysiolog0.45291846
115MP0006072_abnormal_retinal_apoptosis0.45004044
116MP0004742_abnormal_vestibular_system0.42530657
117MP0002139_abnormal_hepatobiliary_system0.42523465
118MP0003890_abnormal_embryonic-extraembry0.42474861
119MP0008007_abnormal_cellular_replicative0.40704941
120MP0001119_abnormal_female_reproductive0.40694728
121MP0003861_abnormal_nervous_system0.40622798
122MP0002152_abnormal_brain_morphology0.40110537
123MP0000534_abnormal_ureter_morphology0.39229131
124MP0002971_abnormal_brown_adipose0.39211226
125MP0001727_abnormal_embryo_implantation0.39162666
126MP0003950_abnormal_plasma_membrane0.37501799
127MP0003942_abnormal_urinary_system0.36465000
128MP0002168_other_aberrant_phenotype0.35713262
129MP0009115_abnormal_fat_cell0.34692375
130MP0003136_yellow_coat_color0.34435085
131MP0000569_abnormal_digit_pigmentation0.33793263
132MP0001324_abnormal_eye_pigmentation0.33583731
133MP0004811_abnormal_neuron_physiology0.33165940
134MP0005253_abnormal_eye_physiology0.32525574
135MP0005391_vision/eye_phenotype0.32060945
136MP0004134_abnormal_chest_morphology0.31694446
137MP0003045_fibrosis0.30440000
138MP0005423_abnormal_somatic_nervous0.30314027
139MP0006036_abnormal_mitochondrial_physio0.30287582
140MP0001440_abnormal_grooming_behavior0.29994006
141MP0005388_respiratory_system_phenotype0.29063588
142MP0002133_abnormal_respiratory_system0.29063588
143MP0002136_abnormal_kidney_physiology0.28967161
144MP0006035_abnormal_mitochondrial_morpho0.28502434
145MP0002269_muscular_atrophy0.28081433
146MP0009278_abnormal_bone_marrow0.26905032
147MP0003633_abnormal_nervous_system0.26659430
148MP0002132_abnormal_respiratory_system0.26649106
149MP0001764_abnormal_homeostasis0.26237829
150MP0001730_embryonic_growth_arrest0.25915033
151MP0002736_abnormal_nociception_after0.25533678
152MP0003111_abnormal_nucleus_morphology0.25325550
153MP0002092_abnormal_eye_morphology0.24465017
154MP0002084_abnormal_developmental_patter0.23063314
155MP0004270_analgesia0.22629915
156MP0003631_nervous_system_phenotype0.21890984
157MP0002295_abnormal_pulmonary_circulatio0.21360798
158MP0002229_neurodegeneration0.20864755
159MP0001958_emphysema0.19900178
160MP0003634_abnormal_glial_cell0.18971024
161MP0009643_abnormal_urine_homeostasis0.18184099
162MP0002572_abnormal_emotion/affect_behav0.18097216
163MP0004036_abnormal_muscle_relaxation0.17834747
164MP0003936_abnormal_reproductive_system0.17755772
165MP0005195_abnormal_posterior_eye0.17522232
166MP0001851_eye_inflammation0.16940696

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.90384992
2Abnormal respiratory epithelium morphology (HP:0012253)9.90384992
3* Abnormal respiratory motile cilium physiology (HP:0012261)9.74285663
4Abnormal ciliary motility (HP:0012262)9.02276337
5* Rhinitis (HP:0012384)7.83186157
6* Chronic bronchitis (HP:0004469)6.07142872
7* Infertility (HP:0000789)5.89909349
8* Bronchiectasis (HP:0002110)4.94345899
9Nephronophthisis (HP:0000090)4.51353539
10* Nasal polyposis (HP:0100582)4.22676004
11Male infertility (HP:0003251)3.84827958
12* Bronchitis (HP:0012387)3.72087208
13Abnormality of the renal medulla (HP:0100957)3.61386224
14* Abnormality of the nasal mucosa (HP:0000433)3.40980912
15Atelectasis (HP:0100750)3.39579775
16Recurrent sinusitis (HP:0011108)3.26261144
17Chronic otitis media (HP:0000389)3.19176645
18Tubulointerstitial nephritis (HP:0001970)3.17606653
19Abnormality of the lower motor neuron (HP:0002366)3.16623175
20Medial flaring of the eyebrow (HP:0010747)3.01490119
21Tubular atrophy (HP:0000092)2.99050501
22Molar tooth sign on MRI (HP:0002419)2.92338979
23Abnormality of midbrain morphology (HP:0002418)2.92338979
24Chronic hepatic failure (HP:0100626)2.77785197
25Hyperactive renin-angiotensin system (HP:0000841)2.77038712
26Tubulointerstitial abnormality (HP:0001969)2.76725201
27* Recurrent otitis media (HP:0000403)2.73929795
28Gonadotropin excess (HP:0000837)2.65740587
29Abnormal spermatogenesis (HP:0008669)2.65125248
30Chronic sinusitis (HP:0011109)2.53898437
31Amyotrophic lateral sclerosis (HP:0007354)2.45499830
32Fibular hypoplasia (HP:0003038)2.44501845
33Tubulointerstitial fibrosis (HP:0005576)2.38657013
34Abnormal drinking behavior (HP:0030082)2.38480336
35Polydipsia (HP:0001959)2.38480336
36Postaxial foot polydactyly (HP:0001830)2.35710105
37Recurrent bronchitis (HP:0002837)2.31053809
38Anencephaly (HP:0002323)2.24539156
39Supernumerary spleens (HP:0009799)2.17612462
40Stage 5 chronic kidney disease (HP:0003774)2.16390785
41Congenital hepatic fibrosis (HP:0002612)2.15550846
42Male pseudohermaphroditism (HP:0000037)2.14222311
43Abnormality of renal excretion (HP:0011036)2.12919663
44Impulsivity (HP:0100710)2.04301780
45Gait imbalance (HP:0002141)2.01867132
46Congenital primary aphakia (HP:0007707)2.00896518
47Azoospermia (HP:0000027)2.00016557
48Dynein arm defect of respiratory motile cilia (HP:0012255)12.5660493
49Absent/shortened dynein arms (HP:0200106)12.5660493
50* Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.7703736
51Oculomotor apraxia (HP:0000657)1.99135412
52Abnormality of the renal cortex (HP:0011035)1.93578637
53Impaired proprioception (HP:0010831)1.92044111
54Sclerocornea (HP:0000647)1.90936156
55Pancreatic fibrosis (HP:0100732)1.89593713
56Abnormal urine output (HP:0012590)1.88610918
57Cystic liver disease (HP:0006706)1.88268172
58Abnormality of dentin (HP:0010299)1.86531303
59Nephrogenic diabetes insipidus (HP:0009806)1.84695401
60Facial cleft (HP:0002006)1.83955955
61Polyuria (HP:0000103)1.83430608
62Furrowed tongue (HP:0000221)1.83298422
63Postaxial hand polydactyly (HP:0001162)1.82778434
64True hermaphroditism (HP:0010459)1.78431364
65Median cleft lip (HP:0000161)1.78054913
66Abnormality of the dental root (HP:0006486)1.77674351
67Taurodontia (HP:0000679)1.77674351
68Abnormality of permanent molar morphology (HP:0011071)1.77674351
69Short ribs (HP:0000773)1.76229308
70Absent frontal sinuses (HP:0002688)1.75509820
71Renal salt wasting (HP:0000127)1.74918974
72Hypoplasia of the capital femoral epiphysis (HP:0003090)1.73083111
73Asplenia (HP:0001746)1.72046295
74Decreased circulating renin level (HP:0003351)1.71344857
75Aplasia/Hypoplasia of the spleen (HP:0010451)1.71070323
76Renal dysplasia (HP:0000110)1.69689116
77Bile duct proliferation (HP:0001408)1.69315182
78Abnormal biliary tract physiology (HP:0012439)1.69315182
79Upper motor neuron abnormality (HP:0002127)1.68000570
80Abnormality of molar (HP:0011077)1.66167305
81Abnormality of molar morphology (HP:0011070)1.66167305
82Occipital encephalocele (HP:0002085)1.66082668
83Bell-shaped thorax (HP:0001591)1.61299736
84Abnormality of the dental pulp (HP:0006479)1.60552080
85Spastic tetraparesis (HP:0001285)1.60112503
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.57588098
87Aplasia/Hypoplasia of the lens (HP:0008063)1.57296985
88Poor coordination (HP:0002370)1.52604101
89Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.52024307
90Hyperkalemia (HP:0002153)1.51191632
91Pancreatic cysts (HP:0001737)1.50136442
92Cholecystitis (HP:0001082)1.49625455
93Abnormal gallbladder physiology (HP:0012438)1.49625455
94Vaginal atresia (HP:0000148)1.49492506
95Aplasia/Hypoplasia of the fibula (HP:0006492)1.49293265
96Preaxial hand polydactyly (HP:0001177)1.48676497
97Genital tract atresia (HP:0001827)1.48646519
98Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.47930609
99Short thorax (HP:0010306)1.47606718
100Broad distal phalanx of finger (HP:0009836)1.46063449
101Heterotopia (HP:0002282)1.44709948
102Hyperaldosteronism (HP:0000859)1.42548861
103Retinal dysplasia (HP:0007973)1.42323271
104Nephropathy (HP:0000112)1.41026618
105Abnormality of the anterior horn cell (HP:0006802)1.40286850
106Degeneration of anterior horn cells (HP:0002398)1.40286850
10711 pairs of ribs (HP:0000878)1.36904787
108Renovascular hypertension (HP:0100817)1.36842734
109Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.35001918
110Absent epiphyses (HP:0010577)1.35001918
111Absent rod-and cone-mediated responses on ERG (HP:0007688)1.32013995
112Dyschromatopsia (HP:0007641)1.31761446
113Short nail (HP:0001799)1.30966579
114Short femoral neck (HP:0100864)1.30686978
115Microglossia (HP:0000171)1.29712413
116Sensory axonal neuropathy (HP:0003390)1.29708323
117Abnormality of chloride homeostasis (HP:0011422)1.27422577
118Abnormality of renin-angiotensin system (HP:0000847)1.27358924
119Decreased central vision (HP:0007663)1.26378367
120Abnormality of the frontal sinuses (HP:0002687)1.22199660
121Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.21514506
122J-shaped sella turcica (HP:0002680)1.19778848
123Bifid scrotum (HP:0000048)1.18798869
124Abnormality of ocular smooth pursuit (HP:0000617)1.18751061
125Hypokalemic alkalosis (HP:0001949)1.17573522
126Breast carcinoma (HP:0003002)1.17384175
127Cone-rod dystrophy (HP:0000548)1.13068766
128Fetal akinesia sequence (HP:0001989)1.08423360
129Retinitis pigmentosa (HP:0000510)1.06456973
130Hyponatremia (HP:0002902)1.05760930
131Abnormal rod and cone electroretinograms (HP:0008323)1.05651167
132Absent speech (HP:0001344)1.04092943
133Hand muscle atrophy (HP:0009130)1.03208379
134Aplasia of the musculature (HP:0100854)1.02901738
135Abnormality of the distal phalanges of the toes (HP:0010182)1.00808920
136Narrow forehead (HP:0000341)0.99267272

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.42471754
2PDK48.42471754
3PDK25.39788659
4TESK15.14498838
5MST44.69527885
6PRKD34.42639909
7EPHA24.10662819
8ICK3.66169331
9PNCK3.09247629
10WNK42.75591921
11PTK2B2.47068389
12STK392.33796717
13NME11.96403912
14NEK21.96278500
15MAP3K21.76690424
16MAPK151.72320904
17STK381.71599804
18LATS11.67884048
19STK241.58028140
20SMG11.55413417
21TLK11.47895482
22CSK1.25513395
23BCR1.24301275
24DYRK1B1.15450490
25MAP3K31.13834256
26WNK11.09535715
27TSSK61.04521547
28TYRO31.02833310
29EPHB11.01051955
30EPHA30.97444742
31LRRK20.96866341
32STK30.90704895
33PDK10.88085746
34MAP3K70.84410109
35ERBB30.84359963
36BRSK20.83746529
37MST1R0.80239956
38LMTK20.72873292
39EEF2K0.72191387
40CCNB10.71395424
41TRPM70.68910654
42DYRK30.68603817
43WNK30.66442439
44PINK10.65829073
45PASK0.65118852
46PRKCI0.64250661
47IRAK10.63739432
48STK38L0.63557522
49ERBB20.63375674
50WEE10.62034313
51TTK0.61171939
52MAP2K70.58716327
53CDC70.57195789
54CAMK1G0.57035365
55INSRR0.53487128
56NTRK20.53262757
57STK160.52341740
58TBK10.52249093
59GRK60.48332616
60CHEK20.44687645
61PLK40.44199470
62MAP3K120.43353755
63MAP4K20.41559679
64PDPK10.40231554
65CHEK10.39723589
66MUSK0.38802688
67CAMK2G0.36109013
68PRKCG0.35498632
69CAMKK20.33920534
70PRKCD0.33679421
71MAP2K20.32722861
72MAP2K40.32435347
73SGK10.32373182
74PRKAA20.32103664
75MAPK130.31034704
76ATR0.30281610
77OXSR10.30056870
78MTOR0.29862362
79PAK10.28936809
80NLK0.27867269
81STK100.27492287
82TESK20.27032968
83CDK30.25313392
84ADRBK20.25273851
85RIPK40.25261725
86IRAK20.24950173
87ATM0.24761820
88MARK20.24384239
89CAMKK10.24227152
90PRKAA10.23662909
91GRK10.23462749
92PAK20.23315229
93ADRBK10.22956866
94DYRK1A0.22634804
95HIPK20.19789547
96PLK10.18974627
97SIK20.18265937
98FER0.17591743
99BMPR1B0.17425595
100ROCK10.16980464
101CDK120.16974948
102TAOK10.15965871
103MAPKAPK50.15938042
104MYLK0.15869439
105RPS6KA20.15311995
106ROCK20.14588768
107BRAF0.14130919
108RPS6KB20.14083453
109PBK0.13885174
110AKT20.13743845
111CDC42BPA0.13592041
112YES10.13396970
113NEK60.13025391
114ABL10.12787011
115PRKCZ0.12778731
116PAK40.11759038
117MAP2K60.11224653
118STK110.11139092
119RPS6KA50.10937517
120PDGFRB0.10724932
121PRKCQ0.09986640
122SGK2230.09982974
123SGK4940.09982974
124RPS6KB10.09782196
125CDK80.09731525
126MAP3K40.09112786
127AURKA0.07086242
128EGFR0.06673879
129PAK60.05145763
130PRKG10.04668128
131MAP3K90.04664220
132RPS6KA10.04380811
133PRKACG0.03291267
134MAP3K100.02181424
135MAPK100.01434222
136GSK3B0.01143650
137MAPKAPK30.00752925
138TRIB30.00712999
139CAMK2A0.00631930
140CDK10.00588709
141CSNK2A10.00466042
142PRKACB0.00400558
143MAPK80.00012891
144PRKD2-0.0370212
145CDK18-0.0366187
146PRKACA-0.0317585
147MARK3-0.0316702
148RIPK1-0.0276222
149CDK2-0.0271646
150PRKDC-0.0260359
151PRKCA-0.0227702
152CDK15-0.0177368
153PRKCB-0.0172484
154ZAP70-0.0170786
155CSNK1D-0.0134464
156RPS6KA3-0.0079320
157PHKG2-0.0025023
158PHKG1-0.0025023

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003604.85720847
2Histidine metabolism_Homo sapiens_hsa003404.42168698
3Vitamin B6 metabolism_Homo sapiens_hsa007504.41563027
4Pyruvate metabolism_Homo sapiens_hsa006204.29324783
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.86719032
6Tyrosine metabolism_Homo sapiens_hsa003503.82446248
7Propanoate metabolism_Homo sapiens_hsa006403.21043795
8Fatty acid biosynthesis_Homo sapiens_hsa000613.05773277
9beta-Alanine metabolism_Homo sapiens_hsa004102.94833067
10Dorso-ventral axis formation_Homo sapiens_hsa043202.67954589
11Glucagon signaling pathway_Homo sapiens_hsa049222.58160413
12Selenocompound metabolism_Homo sapiens_hsa004502.56585889
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.46241375
14Basal transcription factors_Homo sapiens_hsa030222.28036336
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.27298461
16Linoleic acid metabolism_Homo sapiens_hsa005912.24093917
17Caffeine metabolism_Homo sapiens_hsa002322.19534597
18Glycerolipid metabolism_Homo sapiens_hsa005612.10006218
19Pentose phosphate pathway_Homo sapiens_hsa000302.07616283
20Fanconi anemia pathway_Homo sapiens_hsa034601.88615402
21Huntingtons disease_Homo sapiens_hsa050161.86614760
22Oocyte meiosis_Homo sapiens_hsa041141.80110898
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.78793945
24PPAR signaling pathway_Homo sapiens_hsa033201.74336595
25Amphetamine addiction_Homo sapiens_hsa050311.68389420
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61760786
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.57735771
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.56414828
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56338945
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.48978287
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.45345975
32Carbon metabolism_Homo sapiens_hsa012001.41400797
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.38338977
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33430479
35Renin secretion_Homo sapiens_hsa049241.31679780
36Fructose and mannose metabolism_Homo sapiens_hsa000511.26680169
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.25338662
38Tight junction_Homo sapiens_hsa045301.24842766
39Mineral absorption_Homo sapiens_hsa049781.19080150
40Ether lipid metabolism_Homo sapiens_hsa005651.15549994
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14807198
42Fatty acid degradation_Homo sapiens_hsa000711.14381635
43Collecting duct acid secretion_Homo sapiens_hsa049661.14272086
44Cardiac muscle contraction_Homo sapiens_hsa042601.12723962
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10296378
46Fatty acid metabolism_Homo sapiens_hsa012121.08524535
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05705771
48Glutathione metabolism_Homo sapiens_hsa004801.03784668
49mRNA surveillance pathway_Homo sapiens_hsa030150.98172365
50Long-term potentiation_Homo sapiens_hsa047200.97276683
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96288947
52Antigen processing and presentation_Homo sapiens_hsa046120.95362038
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94978897
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92456285
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91185229
56Olfactory transduction_Homo sapiens_hsa047400.89487642
57Notch signaling pathway_Homo sapiens_hsa043300.87778303
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.87276915
59Fat digestion and absorption_Homo sapiens_hsa049750.87030342
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84461947
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83592532
62Hedgehog signaling pathway_Homo sapiens_hsa043400.83252644
63Estrogen signaling pathway_Homo sapiens_hsa049150.81715469
64Circadian rhythm_Homo sapiens_hsa047100.80845495
65Biosynthesis of amino acids_Homo sapiens_hsa012300.80430924
66Starch and sucrose metabolism_Homo sapiens_hsa005000.78898148
67Purine metabolism_Homo sapiens_hsa002300.78631289
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78174444
69Gastric acid secretion_Homo sapiens_hsa049710.77128276
70Arachidonic acid metabolism_Homo sapiens_hsa005900.75568034
71RNA transport_Homo sapiens_hsa030130.74979244
72Chemical carcinogenesis_Homo sapiens_hsa052040.73354720
73Basal cell carcinoma_Homo sapiens_hsa052170.73008905
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72064995
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71268183
76ABC transporters_Homo sapiens_hsa020100.71229569
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69886128
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68123949
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.68075621
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67753691
81Bile secretion_Homo sapiens_hsa049760.67601567
82Sulfur metabolism_Homo sapiens_hsa009200.66171881
83Thyroid hormone synthesis_Homo sapiens_hsa049180.65657551
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.65175243
85Calcium signaling pathway_Homo sapiens_hsa040200.62100646
86Systemic lupus erythematosus_Homo sapiens_hsa053220.61585878
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60575964
88Synaptic vesicle cycle_Homo sapiens_hsa047210.58299563
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56830034
90Phototransduction_Homo sapiens_hsa047440.56631716
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54782753
92Taste transduction_Homo sapiens_hsa047420.54744842
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53587237
94Insulin secretion_Homo sapiens_hsa049110.53401328
95Choline metabolism in cancer_Homo sapiens_hsa052310.53334175
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51447678
97AMPK signaling pathway_Homo sapiens_hsa041520.51312173
98Inositol phosphate metabolism_Homo sapiens_hsa005620.50572303
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.48730072
100Endocytosis_Homo sapiens_hsa041440.45515538
101Salivary secretion_Homo sapiens_hsa049700.44893332
102Nitrogen metabolism_Homo sapiens_hsa009100.44261317
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43770718
104VEGF signaling pathway_Homo sapiens_hsa043700.41342563
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41241576
106Protein digestion and absorption_Homo sapiens_hsa049740.40429797
107Alcoholism_Homo sapiens_hsa050340.40347393
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.40268962
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.39916186
110Metabolic pathways_Homo sapiens_hsa011000.38092756
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37883199
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37170901
113Hepatitis C_Homo sapiens_hsa051600.36921092
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35992852
115Peroxisome_Homo sapiens_hsa041460.34462988
116Circadian entrainment_Homo sapiens_hsa047130.34232121
117cAMP signaling pathway_Homo sapiens_hsa040240.33660806
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.33554046
119Hippo signaling pathway_Homo sapiens_hsa043900.33507062
120Retinol metabolism_Homo sapiens_hsa008300.33474237
121Sphingolipid metabolism_Homo sapiens_hsa006000.31032328
122Hematopoietic cell lineage_Homo sapiens_hsa046400.30838146
123N-Glycan biosynthesis_Homo sapiens_hsa005100.30304890
124Serotonergic synapse_Homo sapiens_hsa047260.29387262
125Pancreatic secretion_Homo sapiens_hsa049720.28441438
126Phagosome_Homo sapiens_hsa041450.27526915
127Complement and coagulation cascades_Homo sapiens_hsa046100.27517090
128Glutamatergic synapse_Homo sapiens_hsa047240.27464372
129Arginine and proline metabolism_Homo sapiens_hsa003300.26510008
130Adherens junction_Homo sapiens_hsa045200.25118852
131Gap junction_Homo sapiens_hsa045400.24543678
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23139542
133Legionellosis_Homo sapiens_hsa051340.22715827
134Regulation of autophagy_Homo sapiens_hsa041400.22570156
135Cocaine addiction_Homo sapiens_hsa050300.21414579
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.21301979
137Butanoate metabolism_Homo sapiens_hsa006500.21013462
138Tryptophan metabolism_Homo sapiens_hsa003800.20526064
139Nicotine addiction_Homo sapiens_hsa050330.20190534
140Axon guidance_Homo sapiens_hsa043600.19915229
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.19355143
142Nucleotide excision repair_Homo sapiens_hsa034200.19330255
143Renin-angiotensin system_Homo sapiens_hsa046140.19135129
144Type I diabetes mellitus_Homo sapiens_hsa049400.17279716
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.14327479
146Vitamin digestion and absorption_Homo sapiens_hsa049770.13688796
147Melanogenesis_Homo sapiens_hsa049160.12401517
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.11858145
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.10726396
150Ovarian steroidogenesis_Homo sapiens_hsa049130.10684717
151Cyanoamino acid metabolism_Homo sapiens_hsa004600.09774994
152Oxidative phosphorylation_Homo sapiens_hsa001900.09672661
153Arginine biosynthesis_Homo sapiens_hsa002200.07765905
154Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.07145489
155Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.06790491

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »