ZMYND12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.97227464
2multicellular organism reproduction (GO:0032504)9.81569217
3sperm-egg recognition (GO:0035036)9.56919602
4epithelial cilium movement (GO:0003351)9.49798407
5plasma membrane fusion (GO:0045026)9.48939393
6acrosome reaction (GO:0007340)9.46633382
7acrosome assembly (GO:0001675)9.30430121
8motile cilium assembly (GO:0044458)8.98848173
9binding of sperm to zona pellucida (GO:0007339)8.63043763
10cell-cell recognition (GO:0009988)8.61911660
11reproduction (GO:0000003)8.55077942
12cilium movement (GO:0003341)8.35717997
13spermatid development (GO:0007286)7.90758395
14piRNA metabolic process (GO:0034587)7.50821676
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.24287670
16regulation of cilium movement (GO:0003352)7.11813817
17male meiosis (GO:0007140)6.75482541
18single fertilization (GO:0007338)6.54237741
19synaptonemal complex organization (GO:0070193)6.44425196
20negative regulation of inclusion body assembly (GO:0090084)6.31149796
21synaptonemal complex assembly (GO:0007130)6.24178895
22sperm capacitation (GO:0048240)5.92846284
23ventricular system development (GO:0021591)5.70978225
24protein neddylation (GO:0045116)5.59911263
25regulation of inclusion body assembly (GO:0090083)5.47543087
26fertilization (GO:0009566)5.39107362
27spermatogenesis (GO:0007283)5.35212043
28male gamete generation (GO:0048232)5.32789404
29organic cation transport (GO:0015695)5.14902514
30negative regulation of norepinephrine secretion (GO:0010700)4.92714350
31spermatid nucleus differentiation (GO:0007289)4.91376537
32gamete generation (GO:0007276)4.89840349
33microtubule severing (GO:0051013)4.86909783
34DNA methylation involved in gamete generation (GO:0043046)4.84482708
35calcium ion-dependent exocytosis (GO:0017156)4.64153943
36cell recognition (GO:0008037)4.41427227
37regulation of microtubule-based movement (GO:0060632)4.33735394
38germ cell development (GO:0007281)4.32677226
39thrombin receptor signaling pathway (GO:0070493)4.29693866
40cellular process involved in reproduction in multicellular organism (GO:0022412)4.27699432
41single strand break repair (GO:0000012)4.24723027
42microtubule depolymerization (GO:0007019)4.22408306
43chromosome organization involved in meiosis (GO:0070192)4.17188756
44sexual reproduction (GO:0019953)4.12358480
45male meiosis I (GO:0007141)3.98960692
46lipoxygenase pathway (GO:0019372)3.86855183
47regulation of norepinephrine secretion (GO:0014061)3.84690996
48negative regulation of heart rate (GO:0010459)3.80410981
49multicellular organismal reproductive process (GO:0048609)3.79986939
50meiotic nuclear division (GO:0007126)3.78139162
51negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.77525628
52embryonic retina morphogenesis in camera-type eye (GO:0060059)3.77000155
53blood coagulation, intrinsic pathway (GO:0007597)3.62584680
54neutrophil activation involved in immune response (GO:0002283)3.56607169
55negative regulation of catecholamine secretion (GO:0033604)3.55167956
56glycerol ether metabolic process (GO:0006662)3.52952054
57adenosine receptor signaling pathway (GO:0001973)3.52502565
58GTP biosynthetic process (GO:0006183)3.47624923
59microtubule bundle formation (GO:0001578)3.47248541
60negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.46478652
61neurotransmitter catabolic process (GO:0042135)3.44527182
62nucleoside diphosphate phosphorylation (GO:0006165)3.43355784
63regulation of integrin-mediated signaling pathway (GO:2001044)3.43187648
64cilium organization (GO:0044782)3.41181831
65axoneme assembly (GO:0035082)3.35308424
66regulation of female receptivity (GO:0045924)3.34873239
67protein localization to cilium (GO:0061512)3.32890021
68positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.31848608
69cilium assembly (GO:0042384)3.31237646
70triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.27860876
71relaxation of smooth muscle (GO:0044557)3.27242535
72intraciliary transport (GO:0042073)3.26550575
73seminiferous tubule development (GO:0072520)3.26450297
74ether metabolic process (GO:0018904)3.24819010
75left/right pattern formation (GO:0060972)3.23038383
76meiosis I (GO:0007127)3.19356629
77regulation of platelet activation (GO:0010543)3.14102227
78cilium morphogenesis (GO:0060271)3.09469107
79multicellular organismal development (GO:0007275)3.08459775
80regulation of response to osmotic stress (GO:0047484)3.07514855
81regulation of platelet aggregation (GO:0090330)3.06519678
82meiotic cell cycle (GO:0051321)3.04218788
83UTP biosynthetic process (GO:0006228)3.03824192
84negative regulation of calcium ion transmembrane transport (GO:1903170)3.01425082
85negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.01425082
86protein polyglutamylation (GO:0018095)3.01176804
87cellular component assembly involved in morphogenesis (GO:0010927)3.00117932
88microtubule-based movement (GO:0007018)2.99097378
89negative regulation of appetite (GO:0032099)2.96998687
90negative regulation of response to food (GO:0032096)2.96998687
91cellular potassium ion homeostasis (GO:0030007)2.95444906
92alditol metabolic process (GO:0019400)2.93135341
93erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.91660051
94L-phenylalanine catabolic process (GO:0006559)2.91660051
95positive regulation of endothelial cell differentiation (GO:0045603)2.91098482
96glycolytic process (GO:0006096)2.89724052
97detection of light stimulus involved in visual perception (GO:0050908)2.89445619
98detection of light stimulus involved in sensory perception (GO:0050962)2.89445619
99monoubiquitinated protein deubiquitination (GO:0035520)2.89418145
100positive regulation of cAMP-mediated signaling (GO:0043950)2.88926979
101female mating behavior (GO:0060180)2.87265173
102androgen biosynthetic process (GO:0006702)2.84732065
103regulation of lipoprotein metabolic process (GO:0050746)2.82523104
104tongue development (GO:0043586)2.82058443
105negative regulation of humoral immune response (GO:0002921)2.81376140
106glycerol metabolic process (GO:0006071)2.80913554
107left/right axis specification (GO:0070986)2.80704174
108microtubule polymerization or depolymerization (GO:0031109)2.79385048
109mitochondrial calcium ion transport (GO:0006851)2.78533788
110low-density lipoprotein particle remodeling (GO:0034374)2.77692403
111protein K11-linked deubiquitination (GO:0035871)2.75632249
112genitalia morphogenesis (GO:0035112)2.73617098
113centriole assembly (GO:0098534)2.71909345
114negative regulation of platelet activation (GO:0010544)2.70050226
115lactate metabolic process (GO:0006089)2.68880963
116xenobiotic catabolic process (GO:0042178)2.68475152
117axon ensheathment in central nervous system (GO:0032291)2.68060685
118central nervous system myelination (GO:0022010)2.68060685
119UTP metabolic process (GO:0046051)2.67938747
120regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.67739643
121negative regulation of homotypic cell-cell adhesion (GO:0034111)2.67238555
122glutathione derivative biosynthetic process (GO:1901687)2.67139500
123glutathione derivative metabolic process (GO:1901685)2.67139500
124aldehyde catabolic process (GO:0046185)2.66113675
125dopamine transport (GO:0015872)2.66004235
126response to xenobiotic stimulus (GO:0009410)2.64267367
127erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.63190859
128L-phenylalanine metabolic process (GO:0006558)2.63190859
129synapsis (GO:0007129)2.61931488
130beta-amyloid metabolic process (GO:0050435)2.61808262
131negative regulation of muscle contraction (GO:0045932)2.61669238
132negative regulation of smooth muscle contraction (GO:0045986)2.60148154
133potassium ion homeostasis (GO:0055075)2.59776729
134negative regulation of protein localization to cell surface (GO:2000009)2.58934890
135RNA localization (GO:0006403)2.57087747
136chromosome condensation (GO:0030261)2.54829345
137negative regulation of thymocyte apoptotic process (GO:0070244)2.53027118
138protein refolding (GO:0042026)2.52493019
139guanosine-containing compound biosynthetic process (GO:1901070)2.51522112
140mitochondrial calcium ion homeostasis (GO:0051560)2.51392393
141centriole replication (GO:0007099)2.50547510
142DNA packaging (GO:0006323)2.49691084
143chaperone-mediated protein complex assembly (GO:0051131)2.48287116
144regulation of memory T cell differentiation (GO:0043380)2.47989830
145high-density lipoprotein particle remodeling (GO:0034375)2.47155487
146cell projection assembly (GO:0030031)2.47050410
147retinol metabolic process (GO:0042572)2.46198331
148nonmotile primary cilium assembly (GO:0035058)2.44719349
149polyamine biosynthetic process (GO:0006596)2.44456331
150negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.43381161
151G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.41079513
152reverse cholesterol transport (GO:0043691)2.41057097
153primary alcohol catabolic process (GO:0034310)2.41038230
154regulation of cytokine production involved in inflammatory response (GO:1900015)2.39793557
155glycerophospholipid catabolic process (GO:0046475)2.38675968
156regulation of type B pancreatic cell apoptotic process (GO:2000674)2.38389674
157retinal metabolic process (GO:0042574)2.38320157
158regulation of macrophage derived foam cell differentiation (GO:0010743)2.37029432
159autophagic vacuole fusion (GO:0000046)2.35455313
160negative regulation of cation channel activity (GO:2001258)2.35209688
161negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.34854349
162extracellular fibril organization (GO:0043206)2.33883443
163carnitine transport (GO:0015879)2.32500257
164amino-acid betaine transport (GO:0015838)2.32500257
165peptidyl-threonine dephosphorylation (GO:0035970)2.28705693
166fusion of sperm to egg plasma membrane (GO:0007342)12.2984424
167cell wall macromolecule metabolic process (GO:0044036)11.6172278
168cell wall macromolecule catabolic process (GO:0016998)11.6172278
169sperm motility (GO:0030317)11.0253607
170cilium or flagellum-dependent cell motility (GO:0001539)10.9450980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.41447953
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.20797386
3EZH2_22144423_ChIP-Seq_EOC_Human3.79414729
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.77404123
5SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.97002204
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81919876
7GBX2_23144817_ChIP-Seq_PC3_Human2.60675767
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.47182912
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.39075988
10VDR_22108803_ChIP-Seq_LS180_Human2.35215459
11LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.34444125
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.34015252
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.27666491
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.17520050
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16671209
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.05230001
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.02165036
18GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.98459362
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97130086
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93086108
21ZNF274_21170338_ChIP-Seq_K562_Hela1.87768142
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.82553761
23KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.81224657
24REST_21632747_ChIP-Seq_MESCs_Mouse1.80938026
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.78177166
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75461155
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75325538
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.74026908
29HTT_18923047_ChIP-ChIP_STHdh_Human1.71629791
30GATA2_19941826_ChIP-Seq_K562_Human1.65408706
31MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.64604808
32RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.63610987
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61954708
34GATA1_19941826_ChIP-Seq_K562_Human1.60159198
35TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.58893465
36TAL1_26923725_Chip-Seq_HPCs_Mouse1.55206273
37KAP1_22055183_ChIP-Seq_ESCs_Mouse1.52521467
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50323809
39KDM2B_26808549_Chip-Seq_REH_Human1.50254368
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50240666
41BCAT_22108803_ChIP-Seq_LS180_Human1.48381348
42TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46469819
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43928604
44FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42442610
45ELK4_26923725_Chip-Seq_MESODERM_Mouse1.42111991
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41296087
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39773712
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.39435615
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38275273
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.38046557
51* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37753230
52STAT1_17558387_ChIP-Seq_HELA_Human1.36833637
53AR_20517297_ChIP-Seq_VCAP_Human1.35415613
54GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.34451682
55FLI1_21867929_ChIP-Seq_TH2_Mouse1.34056294
56SCL_19346495_ChIP-Seq_HPC-7_Human1.32745087
57RNF2_27304074_Chip-Seq_NSC_Mouse1.32080201
58STAT1_20625510_ChIP-Seq_HELA_Human1.31379274
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30757795
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30196179
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.29652042
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29652042
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29564387
64CBP_20019798_ChIP-Seq_JUKART_Human1.27118799
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27118799
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26374379
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26374379
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26246801
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25553176
70TAF15_26573619_Chip-Seq_HEK293_Human1.25104014
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25098943
72* PHF8_20622853_ChIP-Seq_HELA_Human1.25077098
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23038557
74AR_25329375_ChIP-Seq_VCAP_Human1.22607614
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22540919
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.22365612
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20468389
78WDR5_24793694_ChIP-Seq_LNCAP_Human1.20373600
79* HNFA_21074721_ChIP-Seq_CACO-2_Human1.20100345
80ER_23166858_ChIP-Seq_MCF-7_Human1.19593454
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19506603
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.18363223
83* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18359314
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18161266
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17939388
86GATA3_21867929_ChIP-Seq_CD8_Mouse1.17219609
87LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.17017867
88P53_21459846_ChIP-Seq_SAOS-2_Human1.16536355
89GATA3_21878914_ChIP-Seq_MCF-7_Human1.16515730
90* RBPJ_21746931_ChIP-Seq_IB4_Human1.16093233
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16051084
92* ERG_20517297_ChIP-Seq_VCAP_Human1.15771544
93P53_22387025_ChIP-Seq_ESCs_Mouse1.15729346
94SOX2_22085726_ChIP-Seq_NPCs_Mouse1.14319450
95STAT3_23295773_ChIP-Seq_U87_Human1.13780067
96REST_18959480_ChIP-ChIP_MESCs_Mouse1.13503620
97OCT4_18555785_Chip-Seq_ESCs_Mouse1.13301521
98EZH2_27294783_Chip-Seq_ESCs_Mouse1.13281610
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12430177
100SMRT_27268052_Chip-Seq_Bcells_Human1.12146422
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11417868
102IGF1R_20145208_ChIP-Seq_DFB_Human1.11401727
103SOX2_19829295_ChIP-Seq_ESCs_Human1.11067019
104NANOG_19829295_ChIP-Seq_ESCs_Human1.11067019
105CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10710751
106KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10622515
107STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10433403
108GATA4_25053715_ChIP-Seq_YYC3_Human1.09522004
109SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09492309
110KLF4_18555785_Chip-Seq_ESCs_Mouse1.09329967
111P300_18555785_Chip-Seq_ESCs_Mouse1.09097686
112GF1_26923725_Chip-Seq_HPCs_Mouse1.08954994
113* GATA1_19941827_ChIP-Seq_MEL_Mouse1.08829048
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08454489
115* NFYB_21822215_ChIP-Seq_K562_Human1.08445861
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.08390124
117* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.08261427
118ESR1_20079471_ChIP-ChIP_T-47D_Human1.08131325
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08104356
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07909489
121TP63_23658742_ChIP-Seq_EP156T_Human1.07653075
122FUS_26573619_Chip-Seq_HEK293_Human1.07220341
123SOX2_20726797_ChIP-Seq_SW620_Human1.07096878
124OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06769456
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06658960
126SMAD4_21741376_ChIP-Seq_EPCs_Human1.05933142
127* ETV1_20927104_ChIP-Seq_GIST48_Human1.05825108
128ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05419706
129CBP_21632823_ChIP-Seq_H3396_Human1.05300190
130SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05203592
131SPI1_23127762_ChIP-Seq_K562_Human1.04657670
132FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04203293
133RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04115698
134SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03616515
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03421539
136BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03246309
137DROSHA_22980978_ChIP-Seq_HELA_Human1.02953423
138ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02835943
139NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02622277
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02238142
141STAT3_18555785_Chip-Seq_ESCs_Mouse1.01987755
142GATA3_21867929_ChIP-Seq_TH1_Mouse1.01902644
143SMAD4_21799915_ChIP-Seq_A2780_Human1.01775208
144CDX2_22108803_ChIP-Seq_LS180_Human1.01721242
145RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01414558
146RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01079586
147SMAD3_21741376_ChIP-Seq_EPCs_Human1.01007288
148ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00237652
149FOXA1_25552417_ChIP-Seq_VCAP_Human1.00193706
150TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00046132
151ARNT_22903824_ChIP-Seq_MCF-7_Human0.99905875
152* GATA6_21074721_ChIP-Seq_CACO-2_Human0.99705543
153* NFYA_21822215_ChIP-Seq_K562_Human0.99645494
154OCT1_27270436_Chip-Seq_PROSTATE_Human0.99415175
155FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99070935
156NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98892328
157NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98892328
158SALL4_22934838_ChIP-ChIP_CD34+_Human0.98473576
159ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98403937
160SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98210723
161* TBL1_22424771_ChIP-Seq_293T_Human0.98171409
162UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97824206
163SOX2_18555785_Chip-Seq_ESCs_Mouse0.97328582
164* NANOG_20526341_ChIP-Seq_ESCs_Human0.96837484
165POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96682406
166EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95991276
167E2F1_18555785_Chip-Seq_ESCs_Mouse0.94838591
168EWS_26573619_Chip-Seq_HEK293_Human0.94592249
169SOX9_26525672_Chip-Seq_HEART_Mouse0.94354411
170PU1_27457419_Chip-Seq_LIVER_Mouse0.94071901
171TCF4_23295773_ChIP-Seq_U87_Human0.93550169
172CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92753639
173SOX2_21211035_ChIP-Seq_LN229_Human0.92571304
174SMAD1_18555785_Chip-Seq_ESCs_Mouse0.92497025
175CTCF_18555785_Chip-Seq_ESCs_Mouse0.92317994
176TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91834020
177FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91783679
178SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91194647
179RUNX2_22187159_ChIP-Seq_PCA_Human0.91157783

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.23754110
2MP0003698_abnormal_male_reproductive4.94324160
3MP0001929_abnormal_gametogenesis4.27659289
4MP0002653_abnormal_ependyma_morphology3.05273629
5MP0008877_abnormal_DNA_methylation3.02955427
6MP0002210_abnormal_sex_determination2.78028029
7MP0003283_abnormal_digestive_organ2.63394800
8MP0002161_abnormal_fertility/fecundity2.61553331
9MP0005551_abnormal_eye_electrophysiolog2.42440542
10MP0009046_muscle_twitch2.37967524
11MP0001145_abnormal_male_reproductive2.35884766
12MP0000465_gastrointestinal_hemorrhage2.15840283
13MP0002132_abnormal_respiratory_system2.15652807
14MP0001984_abnormal_olfaction2.13095109
15MP0008004_abnormal_stomach_pH2.08909143
16MP0000653_abnormal_sex_gland2.07986489
17MP0005410_abnormal_fertilization12.3521970
18MP0009840_abnormal_foam_cell1.96228156
19MP0008775_abnormal_heart_ventricle1.96071942
20MP0000230_abnormal_systemic_arterial1.87110637
21MP0005083_abnormal_biliary_tract1.86533537
22MP0005645_abnormal_hypothalamus_physiol1.84782064
23MP0000343_altered_response_to1.83440033
24MP0005423_abnormal_somatic_nervous1.80741263
25MP0003011_delayed_dark_adaptation1.78653981
26MP0003329_amyloid_beta_deposits1.76520197
27MP0006292_abnormal_olfactory_placode1.74171610
28MP0002693_abnormal_pancreas_physiology1.73546878
29MP0000383_abnormal_hair_follicle1.71925846
30MP0005670_abnormal_white_adipose1.71272637
31MP0001879_abnormal_lymphatic_vessel1.69566380
32MP0004510_myositis1.67309450
33MP0003718_maternal_effect1.65467229
34MP0004043_abnormal_pH_regulation1.64728469
35MP0006072_abnormal_retinal_apoptosis1.63058720
36MP0005451_abnormal_body_composition1.60367579
37MP0005377_hearing/vestibular/ear_phenot1.59325596
38MP0003878_abnormal_ear_physiology1.59325596
39MP0003303_peritoneal_inflammation1.58789586
40MP0005058_abnormal_lysosome_morphology1.56024717
41MP0004233_abnormal_muscle_weight1.53537532
42MP0001346_abnormal_lacrimal_gland1.53145668
43MP0001486_abnormal_startle_reflex1.52007537
44MP0003724_increased_susceptibility_to1.50425692
45MP0002139_abnormal_hepatobiliary_system1.45258214
46MP0005220_abnormal_exocrine_pancreas1.43726420
47MP0005647_abnormal_sex_gland1.39303077
48MP0006276_abnormal_autonomic_nervous1.38331820
49MP0003638_abnormal_response/metabolism_1.38137408
50MP0005394_taste/olfaction_phenotype1.37173708
51MP0005499_abnormal_olfactory_system1.37173708
52MP0005253_abnormal_eye_physiology1.31897559
53MP0002254_reproductive_system_inflammat1.31885587
54MP0000013_abnormal_adipose_tissue1.30042168
55MP0006036_abnormal_mitochondrial_physio1.28409532
56MP0008789_abnormal_olfactory_epithelium1.28132659
57MP0002160_abnormal_reproductive_system1.27654748
58MP0001944_abnormal_pancreas_morphology1.24319063
59MP0002736_abnormal_nociception_after1.23806154
60MP0001664_abnormal_digestion1.21497300
61MP0002234_abnormal_pharynx_morphology1.21480602
62MP0010678_abnormal_skin_adnexa1.20551787
63MP0005623_abnormal_meninges_morphology1.17478108
64MP0005535_abnormal_body_temperature1.16057515
65MP0004885_abnormal_endolymph1.15638148
66MP0002078_abnormal_glucose_homeostasis1.14845152
67MP0003186_abnormal_redox_activity1.14796658
68MP0002822_catalepsy1.14564181
69MP0010329_abnormal_lipoprotein_level1.14222290
70MP0002272_abnormal_nervous_system1.13463134
71MP0004019_abnormal_vitamin_homeostasis1.13065260
72MP0000566_synostosis1.13060766
73MP0001765_abnormal_ion_homeostasis1.13002953
74MP0001968_abnormal_touch/_nociception1.12552920
75MP0003195_calcinosis1.12263753
76MP0004133_heterotaxia1.10306937
77MP0003656_abnormal_erythrocyte_physiolo1.09814347
78MP0003787_abnormal_imprinting1.09642715
79MP0001756_abnormal_urination1.09580349
80MP0001545_abnormal_hematopoietic_system1.06535439
81MP0005397_hematopoietic_system_phenotyp1.06535439
82MP0004085_abnormal_heartbeat1.06352808
83MP0001970_abnormal_pain_threshold1.06316435
84MP0003950_abnormal_plasma_membrane1.05089927
85MP0002118_abnormal_lipid_homeostasis1.04419269
86MP0009642_abnormal_blood_homeostasis1.04404946
87MP0004270_analgesia1.02672456
88MP0004215_abnormal_myocardial_fiber1.00457572
89MP0002229_neurodegeneration1.00408492
90MP0002837_dystrophic_cardiac_calcinosis0.97132914
91MP0005448_abnormal_energy_balance0.96444673
92MP0005395_other_phenotype0.95395351
93MP0005365_abnormal_bile_salt0.94838800
94MP0005084_abnormal_gallbladder_morpholo0.94474684
95MP0001440_abnormal_grooming_behavior0.94013865
96MP0001663_abnormal_digestive_system0.93642833
97MP0002064_seizures0.93640480
98MP0001188_hyperpigmentation0.93468750
99MP0010155_abnormal_intestine_physiology0.92803533
100MP0005167_abnormal_blood-brain_barrier0.92241405
101MP0005195_abnormal_posterior_eye0.91614876
102MP0003879_abnormal_hair_cell0.89807167
103MP0002638_abnormal_pupillary_reflex0.89729682
104MP0008995_early_reproductive_senescence0.88072328
105MP0002138_abnormal_hepatobiliary_system0.86777804
106MP0002090_abnormal_vision0.86434562
107MP0001835_abnormal_antigen_presentation0.86355277
108MP0002733_abnormal_thermal_nociception0.86284280
109MP0002067_abnormal_sensory_capabilities0.85625436
110MP0003633_abnormal_nervous_system0.84736218
111MP0001963_abnormal_hearing_physiology0.83824517
112MP0002752_abnormal_somatic_nervous0.83492733
113MP0002909_abnormal_adrenal_gland0.83142208
114MP0010386_abnormal_urinary_bladder0.83006804
115MP0002734_abnormal_mechanical_nocicepti0.82986519
116MP0003136_yellow_coat_color0.82227518
117MP0003953_abnormal_hormone_level0.81939683
118MP0005171_absent_coat_pigmentation0.79841611
119MP0000604_amyloidosis0.79523212
120MP0003635_abnormal_synaptic_transmissio0.79417690
121MP0004742_abnormal_vestibular_system0.79102374
122MP0003634_abnormal_glial_cell0.78988867
123MP0002572_abnormal_emotion/affect_behav0.78970619
124MP0005636_abnormal_mineral_homeostasis0.78141102
125MP0001529_abnormal_vocalization0.78114785
126MP0001905_abnormal_dopamine_level0.77520445
127MP0009643_abnormal_urine_homeostasis0.77223130
128MP0005085_abnormal_gallbladder_physiolo0.76489804
129MP0003075_altered_response_to0.75522904
130MP0000920_abnormal_myelination0.75506233
131MP0002332_abnormal_exercise_endurance0.75032205
132MP0005165_increased_susceptibility_to0.74721247
133MP0003631_nervous_system_phenotype0.73856476
134MP0000631_abnormal_neuroendocrine_gland0.72816178
135MP0005389_reproductive_system_phenotype0.70914110
136MP0008875_abnormal_xenobiotic_pharmacok0.70654962
137MP0002102_abnormal_ear_morphology0.70538737
138MP0008872_abnormal_physiological_respon0.68620931
139MP0005391_vision/eye_phenotype0.68614636
140MP0002882_abnormal_neuron_morphology0.68111375
141MP0002277_abnormal_respiratory_mucosa0.67086084
142MP0002876_abnormal_thyroid_physiology0.66610053
143MP0009780_abnormal_chondrocyte_physiolo0.66502838
144MP0010030_abnormal_orbit_morphology0.65890694
145MP0001958_emphysema0.65628970
146MP0002063_abnormal_learning/memory/cond0.64470778
147MP0003632_abnormal_nervous_system0.64282195
148MP0001324_abnormal_eye_pigmentation0.63740132
149MP0005646_abnormal_pituitary_gland0.63466255
150MP0001485_abnormal_pinna_reflex0.63351043
151MP0003690_abnormal_glial_cell0.62544850
152MP0001501_abnormal_sleep_pattern0.58854794
153MP0009697_abnormal_copulation0.58647493
154MP0005332_abnormal_amino_acid0.58483185
155MP0004036_abnormal_muscle_relaxation0.58298284
156MP0001502_abnormal_circadian_rhythm0.58284370
157MP0002735_abnormal_chemical_nociception0.57348141
158MP0000462_abnormal_digestive_system0.57323960
159MP0008569_lethality_at_weaning0.56912629
160MP0000026_abnormal_inner_ear0.56795076
161MP0002557_abnormal_social/conspecific_i0.55230960
162MP0009745_abnormal_behavioral_response0.54961246
163MP0002282_abnormal_trachea_morphology0.52705530
164MP0003786_premature_aging0.51250765
165MP0000534_abnormal_ureter_morphology0.49507814

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.68658503
2Abnormal respiratory motile cilium morphology (HP:0005938)8.32888809
3Abnormal respiratory epithelium morphology (HP:0012253)8.32888809
4Abnormal ciliary motility (HP:0012262)7.11440485
5Rhinitis (HP:0012384)7.04996190
6Chronic bronchitis (HP:0004469)6.99088584
7Petechiae (HP:0000967)5.53981931
8Infertility (HP:0000789)5.35934754
9Prolonged bleeding time (HP:0003010)5.29908737
10Purpura (HP:0000979)4.88525271
11Nasal polyposis (HP:0100582)4.69176217
12Menorrhagia (HP:0000132)4.42684501
13Increased mean platelet volume (HP:0011877)4.36252778
14Abnormal platelet volume (HP:0011876)4.00037942
15Abnormality of the nasal mucosa (HP:0000433)3.91773196
16Male infertility (HP:0003251)3.85622796
17Bronchiectasis (HP:0002110)3.83456954
18Nephronophthisis (HP:0000090)3.72886278
19Bronchitis (HP:0012387)3.46974284
20Tubulointerstitial nephritis (HP:0001970)3.29362205
21Epistaxis (HP:0000421)3.22872650
22Medial flaring of the eyebrow (HP:0010747)3.16774401
23Facial shape deformation (HP:0011334)3.08588652
24Potter facies (HP:0002009)3.08588652
25Gingival bleeding (HP:0000225)2.99320791
26Abnormality of the renal medulla (HP:0100957)2.92651467
27Hyperlipoproteinemia (HP:0010980)2.82428756
28Recurrent otitis media (HP:0000403)2.71597509
29Recurrent sinusitis (HP:0011108)2.69565738
30Congenital stationary night blindness (HP:0007642)2.66509583
31Abnormality of midbrain morphology (HP:0002418)2.61250242
32Molar tooth sign on MRI (HP:0002419)2.61250242
33Occipital encephalocele (HP:0002085)2.51231957
34Decreased circulating renin level (HP:0003351)2.51130653
35Gait imbalance (HP:0002141)2.48348101
36Abnormality of renal resorption (HP:0011038)2.46782861
37Ketoacidosis (HP:0001993)2.45372650
38Dyschromatopsia (HP:0007641)2.42875721
39Congenital primary aphakia (HP:0007707)2.40557238
40Large eyes (HP:0001090)2.38052183
41Chronic otitis media (HP:0000389)2.37483291
42Abnormal pancreas size (HP:0012094)2.37348526
43Hypoglycemic coma (HP:0001325)2.35498004
44True hermaphroditism (HP:0010459)2.32972714
45Abnormal platelet function (HP:0011869)2.29620693
46Impaired platelet aggregation (HP:0003540)2.29620693
47Abnormality of renal excretion (HP:0011036)2.28737747
48Hemiparesis (HP:0001269)2.26550929
49Abnormality of permanent molar morphology (HP:0011071)2.21587839
50Abnormality of the dental root (HP:0006486)2.21587839
51Taurodontia (HP:0000679)2.21587839
52Hypoglycemic seizures (HP:0002173)2.19864360
53Abnormality of the dental pulp (HP:0006479)2.18105051
54Tubulointerstitial abnormality (HP:0001969)2.17056966
55Tubular atrophy (HP:0000092)2.13270314
56Decreased central vision (HP:0007663)2.11383913
57Atelectasis (HP:0100750)2.11347212
58Abnormality of endocrine pancreas physiology (HP:0012093)2.10244439
59Abnormality of the pancreatic islet cells (HP:0006476)2.10244439
60Neurofibrillary tangles (HP:0002185)2.09206370
61Hyperinsulinemic hypoglycemia (HP:0000825)2.05221292
62Abnormality of molar (HP:0011077)2.04749115
63Abnormality of molar morphology (HP:0011070)2.04749115
64Vaginal atresia (HP:0000148)2.04596384
65Abnormal spermatogenesis (HP:0008669)2.03796723
66Hyperactive renin-angiotensin system (HP:0000841)2.02180895
67Pancreatic fibrosis (HP:0100732)2.02085739
68Late onset (HP:0003584)2.01855926
69Nephrogenic diabetes insipidus (HP:0009806)2.01712027
70Abnormal gallbladder physiology (HP:0012438)2.00286135
71Cholecystitis (HP:0001082)2.00286135
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.8538510
73Absent/shortened dynein arms (HP:0200106)11.2990231
74Dynein arm defect of respiratory motile cilia (HP:0012255)11.2990231
75Aplasia/Hypoplasia of the lens (HP:0008063)1.99242573
76Polydipsia (HP:0001959)1.98427788
77Abnormal drinking behavior (HP:0030082)1.98427788
78Spastic tetraparesis (HP:0001285)1.98302394
79Tongue fasciculations (HP:0001308)1.97478627
80Insulin-resistant diabetes mellitus (HP:0000831)1.96873344
81Genital tract atresia (HP:0001827)1.96499552
82Spontaneous hematomas (HP:0007420)1.88434338
83Chronic hepatic failure (HP:0100626)1.86594251
84J-shaped sella turcica (HP:0002680)1.86387915
85Male pseudohermaphroditism (HP:0000037)1.83289091
86Abnormal urine output (HP:0012590)1.83092233
87Abnormal pupillary function (HP:0007686)1.80939139
88Postaxial foot polydactyly (HP:0001830)1.80039677
89Abnormality of macular pigmentation (HP:0008002)1.78928957
90Acanthocytosis (HP:0001927)1.78908746
91Severe visual impairment (HP:0001141)1.78683982
92Renal dysplasia (HP:0000110)1.77630112
93Stage 5 chronic kidney disease (HP:0003774)1.74720367
94Pancreatic cysts (HP:0001737)1.74693300
95Bile duct proliferation (HP:0001408)1.74294140
96Abnormal biliary tract physiology (HP:0012439)1.74294140
97Xanthomatosis (HP:0000991)1.73562280
98Aplasia/Hypoplasia of the tongue (HP:0010295)1.73553057
99Poikilocytosis (HP:0004447)1.71695850
100Poor coordination (HP:0002370)1.70324387
101Muscle fibrillation (HP:0010546)1.70204493
102Amyotrophic lateral sclerosis (HP:0007354)1.70179522
103Oculomotor apraxia (HP:0000657)1.70091804
104Vascular calcification (HP:0004934)1.68313007
105Abnormality of the lower motor neuron (HP:0002366)1.66743616
106Azoospermia (HP:0000027)1.65394339
107Cystic liver disease (HP:0006706)1.64337784
108Postaxial hand polydactyly (HP:0001162)1.64291406
109Optic nerve hypoplasia (HP:0000609)1.63634697
110Retinal dysplasia (HP:0007973)1.61972357
111Abnormality of the renal cortex (HP:0011035)1.61891111
112Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.61817691
113Gonadotropin excess (HP:0000837)1.61700909
114Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.61049721
115Patchy hypopigmentation of hair (HP:0011365)1.59752006
116White forelock (HP:0002211)1.59362004
117Symptomatic seizures (HP:0011145)1.58658952
118Hyperthyroidism (HP:0000836)1.58433601
119Abnormality of renin-angiotensin system (HP:0000847)1.57785082
1203-Methylglutaconic aciduria (HP:0003535)1.56197995
121Agitation (HP:0000713)1.55462831
122Polyuria (HP:0000103)1.54358131
123Congenital hepatic fibrosis (HP:0002612)1.51714129
124Ketosis (HP:0001946)1.51535637
125Cerebral inclusion bodies (HP:0100314)1.51374682
126Aplasia involving bones of the extremities (HP:0009825)1.51099070
127Aplasia involving bones of the upper limbs (HP:0009823)1.51099070
128Aplasia of the phalanges of the hand (HP:0009802)1.51099070
129Cerebellar dysplasia (HP:0007033)1.50129427
130Paralysis (HP:0003470)1.48617679
131Biliary tract neoplasm (HP:0100574)1.46143252
132Abnormality of aromatic amino acid family metabolism (HP:0004338)1.45998775
133Hyperglycemia (HP:0003074)1.45134609
134Ventricular fibrillation (HP:0001663)1.44681566
135Bruising susceptibility (HP:0000978)1.44128373
136Thyroid-stimulating hormone excess (HP:0002925)1.44050216
137Hypoplasia of dental enamel (HP:0006297)1.43637650
138Conjunctival telangiectasia (HP:0000524)1.43532937
139Abnormality of lateral ventricle (HP:0030047)1.43501820
140Chronic sinusitis (HP:0011109)1.42676835
141Cardiovascular calcification (HP:0011915)1.42213530
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.42122957
143Central scotoma (HP:0000603)1.41672748
144Nephropathy (HP:0000112)1.40973505
145Muscle fiber splitting (HP:0003555)1.39952417
146Abnormal rod and cone electroretinograms (HP:0008323)1.39614213
147Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.37848367
148Degeneration of the lateral corticospinal tracts (HP:0002314)1.37848367
149Hypoplasia of the capital femoral epiphysis (HP:0003090)1.36362004
150Absent speech (HP:0001344)1.36087908
151Keratoconus (HP:0000563)1.35829055
152Increased corneal curvature (HP:0100692)1.35829055
153Fetal akinesia sequence (HP:0001989)1.35480607
154Generalized aminoaciduria (HP:0002909)1.33892311
155Abnormality of the vasculature of the conjunctiva (HP:0008054)1.33518762
156Tubulointerstitial fibrosis (HP:0005576)1.31066138

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.35713332
2PDK38.35713332
3PDK25.27341443
4MAP4K24.87374109
5STK393.54027657
6WNK43.32575094
7TESK12.98058502
8PRKD32.62363985
9BMX2.61339887
10MYLK2.58675299
11ICK2.48438426
12PBK2.24381368
13MAP3K22.07777446
14DAPK22.07289237
15ADRBK21.99880211
16PINK11.94916320
17TNIK1.67251350
18PTK2B1.66538405
19ACVR1B1.66286890
20CSF1R1.60631851
21PIK3CG1.59184140
22FRK1.54523378
23MAP3K91.52543025
24BMPR1B1.48425652
25PNCK1.48002082
26WNK11.40966793
27MAPK151.35829443
28TEC1.34936950
29MAPKAPK31.31660899
30MAP3K121.30201585
31GRK11.24567386
32PLK21.23507528
33BTK1.22156030
34TESK21.19039409
35STK381.16455140
36EIF2AK11.15773065
37STK38L1.13211959
38DYRK1B1.09688713
39IKBKB1.08126152
40DAPK31.03894074
41STK160.99588482
42PIM20.98987629
43ILK0.97376617
44MARK10.96661635
45EPHA20.95726763
46PDK10.95508478
47DAPK10.93644604
48LMTK20.93439438
49CCNB10.92053831
50STK240.89825587
51MAP3K30.89369917
52OXSR10.88348152
53FER0.87009032
54NEK20.84757027
55RET0.84292602
56SYK0.80148984
57ZAP700.78890407
58PKN10.77836596
59WNK30.75629626
60ABL20.75626003
61MAPKAPK50.74698643
62PAK30.73516847
63DYRK20.71873423
64TNK20.68631909
65CAMK1G0.67841930
66TAOK30.67210571
67HIPK20.65578469
68MATK0.62012917
69NLK0.61879361
70GRK50.61485239
71STK40.61362605
72PRKCQ0.61284427
73PRKCI0.59901035
74MAP3K50.59382216
75TRPM70.58359653
76ARAF0.58254614
77BRAF0.57777613
78HCK0.55262352
79SGK20.55220943
80NTRK30.53994159
81LYN0.51817617
82PDPK10.51647002
83CHEK20.51085289
84PRKCG0.50974031
85CSK0.50952968
86DYRK1A0.50594946
87AKT30.50449403
88DYRK30.50021148
89GRK60.47400865
90NTRK20.46418094
91OBSCN0.44821361
92PHKG20.44352061
93PHKG10.44352061
94ITK0.42355611
95PRKCD0.41187767
96PRKD10.40108518
97CASK0.39189870
98ERBB20.38885206
99EPHB10.38589174
100CDK120.38444085
101MUSK0.37245802
102LRRK20.37020848
103TLK10.36331179
104TYRO30.35640514
105CDK140.35562969
106CAMK2D0.35308054
107TAOK10.34610545
108CHEK10.33797946
109CAMK2A0.33797775
110GSK3A0.32929453
111CDK150.32504108
112YES10.31786407
113NME10.29719939
114CDK180.28981895
115MARK20.26696529
116CDK50.26462243
117MET0.26245246
118CDK11A0.24098026
119CDK30.23713512
120MAP2K60.22900352
121SGK2230.22792095
122SGK4940.22792095
123PRKAA10.22713900
124MAP3K40.22175511
125PAK60.21957561
126IRAK10.21936900
127PRKG20.21051025
128MST40.20562211
129FGR0.20413960
130ADRBK10.20178853
131PRKCE0.19478116
132BCR0.18952664
133INSRR0.18769071
134NEK60.18742951
135PLK40.18562922
136CAMK2B0.18290027
137PRKG10.17847776
138ERBB40.17186506
139PRKACA0.16800431
140STK30.16720857
141BMPR20.16204232
142MAPK100.15636210
143PRKCA0.15609596
144CAMK2G0.15451755
145ROCK20.14632661
146MINK10.14496271
147PRKCZ0.14343799
148PRKACG0.14026459
149CSNK1D0.13893186
150CSNK1E0.13324035
151MAPK130.13107141
152PRKACB0.12968419
153PAK10.12245724
154RIPK40.11892466
155PASK0.11531762
156PRKCB0.11308415
157EPHA30.11257546

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.22515345
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.78868245
3Fatty acid biosynthesis_Homo sapiens_hsa000613.50735074
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.33140638
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.76392710
6Platelet activation_Homo sapiens_hsa046112.71625261
7Pyruvate metabolism_Homo sapiens_hsa006202.60100449
8Propanoate metabolism_Homo sapiens_hsa006402.58859020
9SNARE interactions in vesicular transport_Homo sapiens_hsa041302.43259167
10Linoleic acid metabolism_Homo sapiens_hsa005912.17587141
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.15866344
12Fatty acid elongation_Homo sapiens_hsa000622.14226915
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04725743
14Pentose phosphate pathway_Homo sapiens_hsa000301.91616844
15Sphingolipid metabolism_Homo sapiens_hsa006001.77603246
16Glycerolipid metabolism_Homo sapiens_hsa005611.75136069
17Synaptic vesicle cycle_Homo sapiens_hsa047211.74322133
18Mineral absorption_Homo sapiens_hsa049781.72594797
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.70891542
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.68987022
21Collecting duct acid secretion_Homo sapiens_hsa049661.61703608
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.60969651
23Ether lipid metabolism_Homo sapiens_hsa005651.59924685
24Cardiac muscle contraction_Homo sapiens_hsa042601.59057747
25Basal transcription factors_Homo sapiens_hsa030221.58945123
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57470689
27Nicotine addiction_Homo sapiens_hsa050331.49873744
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.48762923
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.43777406
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.43188070
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41548267
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.41225415
33Serotonergic synapse_Homo sapiens_hsa047261.35722448
34Glucagon signaling pathway_Homo sapiens_hsa049221.33989839
35Caffeine metabolism_Homo sapiens_hsa002321.32124199
36Renin secretion_Homo sapiens_hsa049241.30192633
37PPAR signaling pathway_Homo sapiens_hsa033201.28776604
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25189560
39Chemical carcinogenesis_Homo sapiens_hsa052041.24937711
40Type II diabetes mellitus_Homo sapiens_hsa049301.23679521
41ABC transporters_Homo sapiens_hsa020101.23396744
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.23097914
43Fructose and mannose metabolism_Homo sapiens_hsa000511.22801712
44Insulin secretion_Homo sapiens_hsa049111.18871084
45Huntingtons disease_Homo sapiens_hsa050161.17082465
46Gap junction_Homo sapiens_hsa045401.16442899
47Starch and sucrose metabolism_Homo sapiens_hsa005001.13318289
48Carbon metabolism_Homo sapiens_hsa012001.13081019
49Glutathione metabolism_Homo sapiens_hsa004801.12301780
50Taste transduction_Homo sapiens_hsa047421.08700910
51Amphetamine addiction_Homo sapiens_hsa050311.08412121
52Fatty acid metabolism_Homo sapiens_hsa012121.07449350
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05249605
54Sulfur metabolism_Homo sapiens_hsa009201.03413220
55Type I diabetes mellitus_Homo sapiens_hsa049401.03019980
56Retinol metabolism_Homo sapiens_hsa008301.02587648
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01929761
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00154830
59Selenocompound metabolism_Homo sapiens_hsa004500.98820141
60Hematopoietic cell lineage_Homo sapiens_hsa046400.98669736
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.98316197
62Biosynthesis of amino acids_Homo sapiens_hsa012300.96021623
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94982826
64Nitrogen metabolism_Homo sapiens_hsa009100.94963072
65GABAergic synapse_Homo sapiens_hsa047270.93874391
66Histidine metabolism_Homo sapiens_hsa003400.92974754
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92966396
68Salivary secretion_Homo sapiens_hsa049700.92182793
69Ovarian steroidogenesis_Homo sapiens_hsa049130.91000658
70Fatty acid degradation_Homo sapiens_hsa000710.90804336
71Long-term depression_Homo sapiens_hsa047300.90681712
72Arachidonic acid metabolism_Homo sapiens_hsa005900.89992747
73Fat digestion and absorption_Homo sapiens_hsa049750.87870406
74Fanconi anemia pathway_Homo sapiens_hsa034600.85382512
75Dorso-ventral axis formation_Homo sapiens_hsa043200.85177726
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85129285
77Hedgehog signaling pathway_Homo sapiens_hsa043400.84876746
78Oocyte meiosis_Homo sapiens_hsa041140.84344906
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81940849
80Lysosome_Homo sapiens_hsa041420.79535852
81Bile secretion_Homo sapiens_hsa049760.77860815
82Gastric acid secretion_Homo sapiens_hsa049710.76391900
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.75460638
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74716876
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74227926
86Purine metabolism_Homo sapiens_hsa002300.74210745
87Olfactory transduction_Homo sapiens_hsa047400.74148004
88Tyrosine metabolism_Homo sapiens_hsa003500.72844068
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72586179
90Metabolic pathways_Homo sapiens_hsa011000.72344932
91Morphine addiction_Homo sapiens_hsa050320.72194047
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72066623
93Calcium signaling pathway_Homo sapiens_hsa040200.70631262
94Circadian rhythm_Homo sapiens_hsa047100.69774024
95Complement and coagulation cascades_Homo sapiens_hsa046100.69142416
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68541113
97Glutamatergic synapse_Homo sapiens_hsa047240.68262002
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67494631
99Butanoate metabolism_Homo sapiens_hsa006500.66469290
100Alcoholism_Homo sapiens_hsa050340.65693590
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65504036
102Pancreatic secretion_Homo sapiens_hsa049720.65021178
103Phenylalanine metabolism_Homo sapiens_hsa003600.64566073
104Circadian entrainment_Homo sapiens_hsa047130.63139943
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60026403
106Systemic lupus erythematosus_Homo sapiens_hsa053220.59546832
107ECM-receptor interaction_Homo sapiens_hsa045120.58975062
108beta-Alanine metabolism_Homo sapiens_hsa004100.57070836
109Protein digestion and absorption_Homo sapiens_hsa049740.56501305
110Oxidative phosphorylation_Homo sapiens_hsa001900.55077157
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.54263328
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53648644
113Inositol phosphate metabolism_Homo sapiens_hsa005620.53591475
114Cocaine addiction_Homo sapiens_hsa050300.52771749
115Rheumatoid arthritis_Homo sapiens_hsa053230.51260458
116Endocytosis_Homo sapiens_hsa041440.50585184
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50537389
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50093266
119Parkinsons disease_Homo sapiens_hsa050120.49857213
120Vitamin digestion and absorption_Homo sapiens_hsa049770.48186248
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47678887
122Thyroid hormone synthesis_Homo sapiens_hsa049180.47650512
123Chemokine signaling pathway_Homo sapiens_hsa040620.46927927
124Phagosome_Homo sapiens_hsa041450.45337820
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43123081
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43071341
127Regulation of autophagy_Homo sapiens_hsa041400.42860678
128Phototransduction_Homo sapiens_hsa047440.41965997
129Arginine and proline metabolism_Homo sapiens_hsa003300.40788987
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37558759
131Tryptophan metabolism_Homo sapiens_hsa003800.36614496
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36415717
133Protein export_Homo sapiens_hsa030600.35194696
134Vibrio cholerae infection_Homo sapiens_hsa051100.34961298
135Steroid biosynthesis_Homo sapiens_hsa001000.34441245
136Peroxisome_Homo sapiens_hsa041460.33789201
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32511640
138Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32243614
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30476863

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