ZMYND15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. A similar gene in mice has been shown to act as a testis-specific transcriptional repressor by recruiting histone deacetylase enzymes to regulate spatiotemporal expression of many haploid genes. This protein may play an important role in spermatogenesis. Alternative splicing results in multiple transcript variants and protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.44809638
2cell wall macromolecule metabolic process (GO:0044036)9.17660422
3cell wall macromolecule catabolic process (GO:0016998)9.17660422
4sperm-egg recognition (GO:0035036)8.82376635
5acrosome assembly (GO:0001675)8.67246717
6multicellular organism reproduction (GO:0032504)8.31836668
7cilium or flagellum-dependent cell motility (GO:0001539)8.22816613
8cell-cell recognition (GO:0009988)8.09982995
9binding of sperm to zona pellucida (GO:0007339)7.95755966
10axonemal dynein complex assembly (GO:0070286)7.93978963
11plasma membrane fusion (GO:0045026)7.48616439
12motile cilium assembly (GO:0044458)7.41427894
13epithelial cilium movement (GO:0003351)7.30306585
14reproduction (GO:0000003)7.21225889
15* spermatid development (GO:0007286)7.13424399
16cilium movement (GO:0003341)6.13479537
17piRNA metabolic process (GO:0034587)6.10846957
18regulation of cilium movement (GO:0003352)6.08208987
19organic cation transport (GO:0015695)5.69158652
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.64016224
21male meiosis (GO:0007140)5.60841923
22negative regulation of inclusion body assembly (GO:0090084)5.58129584
23single fertilization (GO:0007338)5.53650100
24synaptonemal complex organization (GO:0070193)5.51326470
25synaptonemal complex assembly (GO:0007130)5.34797099
26sperm capacitation (GO:0048240)5.32347844
27spermatogenesis (GO:0007283)5.08460770
28NIK/NF-kappaB signaling (GO:0038061)5.06335048
29male gamete generation (GO:0048232)5.06105154
30negative regulation of interleukin-12 production (GO:0032695)4.99225483
31response to peptidoglycan (GO:0032494)4.95361673
32fertilization (GO:0009566)4.84801013
33gamete generation (GO:0007276)4.62284883
34interferon-gamma secretion (GO:0072643)4.59952689
35macrophage activation involved in immune response (GO:0002281)4.58108306
36regulation of inclusion body assembly (GO:0090083)4.45400473
37natural killer cell mediated immunity (GO:0002228)4.10709965
38natural killer cell mediated cytotoxicity (GO:0042267)4.10709965
39ventricular system development (GO:0021591)4.10677871
40* cellular process involved in reproduction in multicellular organism (GO:0022412)4.06701659
41regulation of T-helper 2 cell differentiation (GO:0045628)4.02665105
42seminiferous tubule development (GO:0072520)4.00637185
43* germ cell development (GO:0007281)3.93104297
44lipopolysaccharide-mediated signaling pathway (GO:0031663)3.89869355
45DNA methylation involved in gamete generation (GO:0043046)3.79341783
46male meiosis I (GO:0007141)3.79315192
47sequestering of actin monomers (GO:0042989)3.70335412
48RNA destabilization (GO:0050779)3.67215653
49positive regulation of gamma-delta T cell activation (GO:0046645)3.62375044
50positive regulation of type 2 immune response (GO:0002830)3.61753158
51multicellular organismal reproductive process (GO:0048609)3.60251976
52detection of molecule of bacterial origin (GO:0032490)3.57887679
53cell recognition (GO:0008037)3.57392931
54T-helper 1 type immune response (GO:0042088)3.57151158
55antigen processing and presentation of endogenous antigen (GO:0019883)3.54926268
56calcium ion-dependent exocytosis (GO:0017156)3.50665606
57regulation of vitamin D biosynthetic process (GO:0060556)3.48428354
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.48395832
59regulation of microtubule-based movement (GO:0060632)3.47582111
60left/right pattern formation (GO:0060972)3.47501244
61chromosome organization involved in meiosis (GO:0070192)3.46565178
62regulation of interferon-beta biosynthetic process (GO:0045357)3.39610897
63regulation of mast cell degranulation (GO:0043304)3.37627623
64sexual reproduction (GO:0019953)3.34088163
65negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.33761317
66negative regulation of cell killing (GO:0031342)3.33761317
67microtubule depolymerization (GO:0007019)3.33660993
68positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.33087102
69glycosphingolipid catabolic process (GO:0046479)3.27555153
70regulation of mononuclear cell migration (GO:0071675)3.26792564
71interferon-gamma-mediated signaling pathway (GO:0060333)3.26488461
72amino-acid betaine transport (GO:0015838)3.22251389
73carnitine transport (GO:0015879)3.22251389
74germinal center formation (GO:0002467)3.19535795
75granulocyte activation (GO:0036230)3.18919933
76macrophage activation (GO:0042116)3.18917870
77chromosome condensation (GO:0030261)3.18339225
78cellular response to thyroid hormone stimulus (GO:0097067)3.17348291
79detection of other organism (GO:0098543)3.16483601
80glycerol ether metabolic process (GO:0006662)3.13737593
81amino sugar catabolic process (GO:0046348)3.11366307
82DNA packaging (GO:0006323)3.10971058
83type I interferon signaling pathway (GO:0060337)3.10745328
84cellular response to type I interferon (GO:0071357)3.10745328
85regulation of mast cell activation involved in immune response (GO:0033006)3.10320944
86carnitine transmembrane transport (GO:1902603)3.10109883
87myeloid cell activation involved in immune response (GO:0002275)3.07449940
88response to type I interferon (GO:0034340)3.06699514
89positive regulation of mast cell degranulation (GO:0043306)3.06248962
90positive regulation of mast cell activation involved in immune response (GO:0033008)3.06248962
91oligosaccharide catabolic process (GO:0009313)3.05746436
92negative regulation of cytokine production involved in immune response (GO:0002719)3.03569920
93detection of external biotic stimulus (GO:0098581)3.03022855
94membrane protein intracellular domain proteolysis (GO:0031293)3.02897957
95microtubule severing (GO:0051013)3.00690804
96positive regulation of antigen processing and presentation (GO:0002579)3.00466203
97negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.98746508
98positive regulation of mast cell activation (GO:0033005)2.98076651
99regulation of gamma-delta T cell activation (GO:0046643)2.98005529
100positive regulation of chemokine biosynthetic process (GO:0045080)2.97695242
101antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.97032789
102regulation of myeloid leukocyte mediated immunity (GO:0002886)2.96732474
103positive regulation of cellular amide metabolic process (GO:0034250)2.95704022
104meiotic nuclear division (GO:0007126)2.94227434
105regulation of protein polyubiquitination (GO:1902914)2.93879365
106defense response to protozoan (GO:0042832)2.93786630
107neutrophil activation (GO:0042119)2.92975058
108regulation of leukocyte degranulation (GO:0043300)2.92634550
109glycolipid catabolic process (GO:0019377)2.91940243
110genitalia morphogenesis (GO:0035112)2.91513357
111positive regulation of monocyte chemotaxis (GO:0090026)2.91337549
112multicellular organismal development (GO:0007275)2.91223685
113fructose metabolic process (GO:0006000)2.91097137
114cellular extravasation (GO:0045123)2.90285498
115antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.90127247
116antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.90127247
117negative regulation of erythrocyte differentiation (GO:0045647)2.89599084
118detection of bacterium (GO:0016045)2.89023923
119regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.87935189
120positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.85774545
121positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.85680321
122ether metabolic process (GO:0018904)2.84746565
123microglial cell activation (GO:0001774)2.84504939
124meiosis I (GO:0007127)2.82733841
125regulation of interferon-alpha production (GO:0032647)2.81932275
126immunoglobulin mediated immune response (GO:0016064)2.81766987
127lymphocyte chemotaxis (GO:0048247)2.81753346
128response to protozoan (GO:0001562)2.81692678
129peptide catabolic process (GO:0043171)2.79837817
130regulation of cytokine secretion involved in immune response (GO:0002739)2.78371826
131regulation of vitamin metabolic process (GO:0030656)2.77282790
132positive regulation of leukocyte degranulation (GO:0043302)2.77142980
133regulation of type 2 immune response (GO:0002828)2.76052270
134negative regulation of necroptotic process (GO:0060546)2.72959827
135detection of biotic stimulus (GO:0009595)2.72697128
136positive regulation by symbiont of host defense response (GO:0052509)2.71617354
137modulation by symbiont of host defense response (GO:0052031)2.71617354
138modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71617354
139modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71617354
140positive regulation by organism of defense response of other organism involved in symbiotic interact2.71617354
141modulation by symbiont of host immune response (GO:0052553)2.71617354
142regulation of necroptotic process (GO:0060544)2.71504245
143leukocyte mediated cytotoxicity (GO:0001909)2.71073229
144positive regulation of NF-kappaB import into nucleus (GO:0042346)2.70202921
145positive regulation of T-helper cell differentiation (GO:0045624)2.69741836
146negative regulation of granulocyte differentiation (GO:0030853)2.69447966
147positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.69243692
148regulation of mast cell activation (GO:0033003)2.68453637
149regulation of interleukin-12 production (GO:0032655)2.68283156
150regulation of T-helper 1 cell differentiation (GO:0045625)2.67818390
151fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.67678691
152response to acidic pH (GO:0010447)2.65822990
153N-acetylneuraminate metabolic process (GO:0006054)2.65813943
154regulation of antigen processing and presentation (GO:0002577)2.65226840
155regulation of macrophage chemotaxis (GO:0010758)2.63727899
156response to interferon-gamma (GO:0034341)2.61912196
157regulation of T cell tolerance induction (GO:0002664)2.61714820
158regulation of podosome assembly (GO:0071801)2.61545140
159regulation of chemokine biosynthetic process (GO:0045073)2.60002712
160neutrophil activation involved in immune response (GO:0002283)2.59100365
161response to thyroid hormone (GO:0097066)2.57241079
162cellular response to lipopolysaccharide (GO:0071222)2.56252188
163cellular response to molecule of bacterial origin (GO:0071219)2.56194296
164response to muramyl dipeptide (GO:0032495)2.56140548
165cellular response to interferon-gamma (GO:0071346)2.55855356
166meiotic cell cycle (GO:0051321)2.54796876
167myeloid leukocyte activation (GO:0002274)2.54576926
168positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.52807180
169low-density lipoprotein particle clearance (GO:0034383)2.50510778
170protein localization to cilium (GO:0061512)2.48399947
171cytokine secretion (GO:0050663)2.47774161
172myeloid dendritic cell differentiation (GO:0043011)2.47260263
173spermatid nucleus differentiation (GO:0007289)2.44214732
174positive regulation of interferon-alpha production (GO:0032727)2.42155381
175cellular response to arsenic-containing substance (GO:0071243)2.41120459
176ruffle organization (GO:0031529)2.40923763
177sperm motility (GO:0030317)10.6004270
178fusion of sperm to egg plasma membrane (GO:0007342)10.0969309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.68912652
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.67200727
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.63755380
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.31687831
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.05895471
6IRF8_27001747_Chip-Seq_BMDM_Mouse2.75996084
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.75704764
8LXR_22292898_ChIP-Seq_THP-1_Human2.39502677
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.34179910
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.28356591
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.23575199
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.17925458
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.17686577
14PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.12297367
15SPI1_23127762_ChIP-Seq_K562_Human2.10699440
16VDR_24763502_ChIP-Seq_THP-1_Human2.09684787
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07075862
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99487528
19VDR_21846776_ChIP-Seq_THP-1_Human1.96539537
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93796669
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93463931
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90082657
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89002454
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81860399
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81684297
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78273691
27PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.71397016
28RUNX_20019798_ChIP-Seq_JUKART_Human1.70751714
29VDR_24787735_ChIP-Seq_THP-1_Human1.68697405
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64603029
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60287520
32* BCL6_27268052_Chip-Seq_Bcells_Human1.58149467
33LXR_22158963_ChIP-Seq_LIVER_Mouse1.56903203
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.56703197
35FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56543579
36* BCOR_27268052_Chip-Seq_Bcells_Human1.55554677
37KDM2B_26808549_Chip-Seq_DND41_Human1.53454114
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50722762
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49592704
40* ELF1_20517297_ChIP-Seq_JURKAT_Human1.49281364
41VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.48880838
42MAF_26560356_Chip-Seq_TH1_Human1.46490581
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46040218
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45376096
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.44756837
46SPI1_23547873_ChIP-Seq_NB4_Human1.43962183
47PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43234789
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.42757314
49SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40099849
50ELK4_26923725_Chip-Seq_MESODERM_Mouse1.39928437
51SCL_19346495_ChIP-Seq_HPC-7_Human1.38367858
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37250828
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35231114
54SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35222477
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35137196
56STAT1_17558387_ChIP-Seq_HELA_Human1.34148095
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31623274
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.30011928
59GATA1_19941826_ChIP-Seq_K562_Human1.29592994
60P68_20966046_ChIP-Seq_HELA_Human1.28524084
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.28316248
62CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28231724
63ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27395365
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.26325648
65* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26216369
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26115978
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.25727640
68SMC4_20622854_ChIP-Seq_HELA_Human1.24957595
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24021337
70KDM2B_26808549_Chip-Seq_K562_Human1.22712611
71UTX_26944678_Chip-Seq_JUKART_Human1.22475156
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20936533
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20870760
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20548616
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.19743916
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18765656
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18533920
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18499573
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18141375
80MAF_26560356_Chip-Seq_TH2_Human1.17978731
81VDR_22108803_ChIP-Seq_LS180_Human1.17345022
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16929540
83RXR_22158963_ChIP-Seq_LIVER_Mouse1.16729512
84RACK7_27058665_Chip-Seq_MCF-7_Human1.16271959
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16216761
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15228996
87* SA1_27219007_Chip-Seq_ERYTHROID_Human1.13286029
88FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12362975
89SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12293094
90STAT1_20625510_ChIP-Seq_HELA_Human1.12134979
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12078918
92EZH2_22144423_ChIP-Seq_EOC_Human1.11295747
93GATA1_19941827_ChIP-Seq_MEL86_Mouse1.10873608
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09015428
95SA1_27219007_Chip-Seq_Bcells_Human1.07839170
96GATA2_21666600_ChIP-Seq_HMVEC_Human1.07725778
97FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07352089
98TCF7_22412390_ChIP-Seq_EML_Mouse1.07102446
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06941955
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06846709
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06840447
102TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06371688
103CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05494802
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04384874
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03727244
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03213965
107* E2F1_20622854_ChIP-Seq_HELA_Human1.02051798
108GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.01772141
109MYB_26560356_Chip-Seq_TH2_Human1.01234995
110P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01054244
111GATA3_21867929_ChIP-Seq_CD8_Mouse1.00113662
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99908681
113KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99519403
114NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99362107
115PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98925287
116RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98866975
117SOX2_22085726_ChIP-Seq_NPCs_Mouse0.98301651
118MYC_22102868_ChIP-Seq_BL_Human0.98066872
119TP63_22573176_ChIP-Seq_HFKS_Human0.97878282
120RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97853723
121LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.96931212
122CBP_20019798_ChIP-Seq_JUKART_Human0.96390120
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96390120
124MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96262347
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96105392
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96105392
127GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95642592
128* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95307797
129CTCF_26484167_Chip-Seq_Bcells_Mouse0.95124946
130SPI1_20517297_ChIP-Seq_HL60_Human0.93980740
131* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93725237
132GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93353213
133EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92944145
134JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92778051
135EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92202138
136SMRT_27268052_Chip-Seq_Bcells_Human0.91729156
137SPI1_26923725_Chip-Seq_HPCs_Mouse0.91728202
138* PHF8_20622854_ChIP-Seq_HELA_Human0.91248410
139TBX20_22328084_ChIP-Seq_HEART_Mouse0.90955512
140TBX20_22080862_ChIP-Seq_HEART_Mouse0.90955512
141PU_27001747_Chip-Seq_BMDM_Mouse0.90876363
142KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.90300247
143MYB_26560356_Chip-Seq_TH1_Human0.90090737
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88893353
145KDM2B_26808549_Chip-Seq_REH_Human0.88610431
146LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88203183
147KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88111027
148FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87942818
149GF1_26923725_Chip-Seq_HPCs_Mouse0.87481205
150P53_21459846_ChIP-Seq_SAOS-2_Human0.87478485
151MYC_27129775_Chip-Seq_CORNEA_Mouse0.87431599
152RUNX1_26923725_Chip-Seq_HPCs_Mouse0.87323542
153CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.85674525
154GATA3_21867929_ChIP-Seq_TH1_Mouse0.85087769
155EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85033573
156ESET_19884257_ChIP-Seq_ESCs_Mouse0.84237816
157NFE2_27457419_Chip-Seq_LIVER_Mouse0.83543042
158KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83157550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.01206522
2MP0002138_abnormal_hepatobiliary_system3.84595270
3* MP0003698_abnormal_male_reproductive3.40606036
4MP0001835_abnormal_antigen_presentation3.38762143
5* MP0001929_abnormal_gametogenesis3.11777848
6MP0004510_myositis2.87556498
7MP0000685_abnormal_immune_system2.54990757
8MP0003436_decreased_susceptibility_to2.48853830
9MP0005670_abnormal_white_adipose2.36981283
10MP0005451_abnormal_body_composition2.28867936
11MP0008877_abnormal_DNA_methylation2.15378597
12MP0005410_abnormal_fertilization10.5906803
13MP0001348_abnormal_lacrimal_gland1.94724742
14MP0000569_abnormal_digit_pigmentation1.92726705
15MP0001790_abnormal_immune_system1.89447717
16MP0005387_immune_system_phenotype1.89447717
17MP0005167_abnormal_blood-brain_barrier1.87612287
18MP0000343_altered_response_to1.86340670
19MP0002148_abnormal_hypersensitivity_rea1.85151845
20MP0009785_altered_susceptibility_to1.77916487
21* MP0002161_abnormal_fertility/fecundity1.74732506
22MP0005000_abnormal_immune_tolerance1.73290019
23MP0002210_abnormal_sex_determination1.73012509
24* MP0002419_abnormal_innate_immunity1.70110659
25MP0005025_abnormal_response_to1.70040475
26MP0001800_abnormal_humoral_immune1.65107376
27MP0006082_CNS_inflammation1.62455947
28MP0008004_abnormal_stomach_pH1.59909405
29MP0002166_altered_tumor_susceptibility1.59449856
30MP0002723_abnormal_immune_serum1.53584185
31* MP0002452_abnormal_antigen_presenting1.52255705
32MP0005058_abnormal_lysosome_morphology1.51947228
33MP0003690_abnormal_glial_cell1.51524432
34MP0003303_peritoneal_inflammation1.50211969
35MP0005166_decreased_susceptibility_to1.47781596
36MP0005310_abnormal_salivary_gland1.45433532
37MP0001873_stomach_inflammation1.44823825
38MP0000604_amyloidosis1.44212788
39* MP0001145_abnormal_male_reproductive1.43043749
40MP0004947_skin_inflammation1.38909383
41MP0002139_abnormal_hepatobiliary_system1.33344380
42MP0002405_respiratory_system_inflammati1.31441984
43MP0005360_urolithiasis1.31155350
44MP0003806_abnormal_nucleotide_metabolis1.30753357
45MP0005671_abnormal_response_to1.29716018
46MP0002277_abnormal_respiratory_mucosa1.24989345
47* MP0001819_abnormal_immune_cell1.22701650
48MP0003828_pulmonary_edema1.20400244
49* MP0002420_abnormal_adaptive_immunity1.20097392
50MP0008469_abnormal_protein_level1.18875366
51MP0008260_abnormal_autophagy1.17853624
52MP0003329_amyloid_beta_deposits1.17844557
53MP0001853_heart_inflammation1.17314194
54* MP0000653_abnormal_sex_gland1.15674553
55MP0002006_tumorigenesis1.14267581
56MP0009278_abnormal_bone_marrow1.14036968
57MP0003191_abnormal_cellular_cholesterol1.13899460
58MP0009840_abnormal_foam_cell1.12183574
59MP0003448_altered_tumor_morphology1.11517538
60MP0003724_increased_susceptibility_to1.11112563
61MP0005164_abnormal_response_to1.09482837
62MP0001533_abnormal_skeleton_physiology1.08904656
63MP0003195_calcinosis1.08199899
64MP0003878_abnormal_ear_physiology1.07715390
65MP0005377_hearing/vestibular/ear_phenot1.07715390
66MP0005397_hematopoietic_system_phenotyp1.06628618
67MP0001545_abnormal_hematopoietic_system1.06628618
68MP0001845_abnormal_inflammatory_respons1.04819217
69MP0002132_abnormal_respiratory_system1.04212112
70MP0003252_abnormal_bile_duct1.02551579
71MP0003300_gastrointestinal_ulcer1.02380586
72MP0009764_decreased_sensitivity_to1.02123235
73MP0003172_abnormal_lysosome_physiology0.99388271
74MP0005464_abnormal_platelet_physiology0.99096873
75MP0004883_abnormal_blood_vessel0.97318180
76MP0000678_abnormal_parathyroid_gland0.97057655
77MP0001765_abnormal_ion_homeostasis0.96256380
78MP0002332_abnormal_exercise_endurance0.95123550
79MP0003646_muscle_fatigue0.94376054
80MP0005647_abnormal_sex_gland0.94234447
81MP0003656_abnormal_erythrocyte_physiolo0.93954643
82MP0000920_abnormal_myelination0.92749477
83MP0008875_abnormal_xenobiotic_pharmacok0.91895271
84MP0005365_abnormal_bile_salt0.91771874
85MP0000716_abnormal_immune_system0.90702356
86MP0005390_skeleton_phenotype0.88819681
87MP0000609_abnormal_liver_physiology0.86825131
88MP0002009_preneoplasia0.86623401
89MP0003045_fibrosis0.84081911
90MP0005623_abnormal_meninges_morphology0.83802614
91MP0001346_abnormal_lacrimal_gland0.81887793
92MP0002933_joint_inflammation0.81171984
93* MP0000249_abnormal_blood_vessel0.79899234
94MP0003183_abnormal_peptide_metabolism0.79848275
95MP0002295_abnormal_pulmonary_circulatio0.79025551
96MP0005076_abnormal_cell_differentiation0.78793316
97MP0002398_abnormal_bone_marrow0.77279078
98MP0002653_abnormal_ependyma_morphology0.75870062
99MP0010155_abnormal_intestine_physiology0.74856607
100MP0008874_decreased_physiological_sensi0.74584356
101MP0010307_abnormal_tumor_latency0.74276473
102MP0002136_abnormal_kidney_physiology0.74151396
103MP0005666_abnormal_adipose_tissue0.73240265
104MP0009765_abnormal_xenobiotic_induced0.73173593
105MP0003795_abnormal_bone_structure0.73113164
106MP0004019_abnormal_vitamin_homeostasis0.72472168
107MP0002722_abnormal_immune_system0.72177715
108MP0005085_abnormal_gallbladder_physiolo0.72060101
109MP0003091_abnormal_cell_migration0.71306703
110MP0005083_abnormal_biliary_tract0.70874214
111MP0006054_spinal_hemorrhage0.70562954
112MP0003879_abnormal_hair_cell0.70006349
113MP0001851_eye_inflammation0.69347311
114MP0002429_abnormal_blood_cell0.68666541
115MP0009763_increased_sensitivity_to0.67519863
116MP0005319_abnormal_enzyme/_coenzyme0.66781870
117MP0001849_ear_inflammation0.64593137
118MP0002998_abnormal_bone_remodeling0.64554021
119MP0002928_abnormal_bile_duct0.64047358
120MP0000689_abnormal_spleen_morphology0.63237285
121MP0001663_abnormal_digestive_system0.63236031
122MP0005535_abnormal_body_temperature0.63057315
123MP0000858_altered_metastatic_potential0.62152184
124MP0005023_abnormal_wound_healing0.61599355
125MP0005165_increased_susceptibility_to0.61543527
126MP0002971_abnormal_brown_adipose0.60271788
127MP0003705_abnormal_hypodermis_morpholog0.59741078
128MP0009115_abnormal_fat_cell0.58153434
129MP0002160_abnormal_reproductive_system0.56819224
130MP0009333_abnormal_splenocyte_physiolog0.56518508
131MP0010329_abnormal_lipoprotein_level0.56187988
132MP0002163_abnormal_gland_morphology0.56168168
133MP0005584_abnormal_enzyme/coenzyme_acti0.56152841
134MP0003566_abnormal_cell_adhesion0.55988675
135MP0003075_altered_response_to0.54441080
136MP0003453_abnormal_keratinocyte_physiol0.54159825

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.49344378
2Abnormal respiratory epithelium morphology (HP:0012253)7.26559134
3Abnormal respiratory motile cilium morphology (HP:0005938)7.26559134
4Nasal polyposis (HP:0100582)7.23035917
5Rhinitis (HP:0012384)6.29934483
6Abnormality of the nasal mucosa (HP:0000433)6.19375719
7Abnormality of liposaccharide metabolism (HP:0010968)6.01180087
8Abnormality of glycosphingolipid metabolism (HP:0004343)6.01180087
9Abnormality of glycolipid metabolism (HP:0010969)6.01180087
10Chronic bronchitis (HP:0004469)5.91586545
11Abnormal ciliary motility (HP:0012262)5.76989835
12Infertility (HP:0000789)5.66466160
13Increased cerebral lipofuscin (HP:0011813)4.38061747
14Bronchitis (HP:0012387)4.32123519
15Bronchiectasis (HP:0002110)4.19926027
16Vacuolated lymphocytes (HP:0001922)4.08911420
17Dysostosis multiplex (HP:0000943)4.02456781
18Disinhibition (HP:0000734)3.52461397
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.50719893
20Male infertility (HP:0003251)3.41434063
21Recurrent bronchitis (HP:0002837)3.25814835
22Nephronophthisis (HP:0000090)3.25036577
23Abnormality of polysaccharide metabolism (HP:0011012)3.21756947
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.21756947
25Abnormality of mucopolysaccharide metabolism (HP:0011020)3.21756947
26Recurrent bacterial skin infections (HP:0005406)3.18302224
27Recurrent sinusitis (HP:0011108)3.11877781
28Axonal loss (HP:0003447)3.10346985
29Recurrent abscess formation (HP:0002722)3.07625034
30Stomatitis (HP:0010280)3.04285014
31Urinary glycosaminoglycan excretion (HP:0003541)3.02653983
32Mucopolysacchariduria (HP:0008155)3.02653983
33Obstructive lung disease (HP:0006536)3.01550545
34Chronic obstructive pulmonary disease (HP:0006510)3.01550545
35Mutism (HP:0002300)2.98794061
36Nuclear cataract (HP:0100018)2.87481191
37Eczematoid dermatitis (HP:0000976)2.85866750
38Purpura (HP:0000979)2.84909629
39Severe visual impairment (HP:0001141)2.83042587
40Recurrent gram-negative bacterial infections (HP:0005420)2.81429737
41Systemic lupus erythematosus (HP:0002725)2.80309444
42Recurrent otitis media (HP:0000403)2.70259553
43Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.68959174
44Loss of speech (HP:0002371)2.67341751
45Increased serum ferritin (HP:0003281)2.65843207
46Myocardial infarction (HP:0001658)2.65161536
47Gastrointestinal infarctions (HP:0005244)2.64620962
48Abnormality of the renal medulla (HP:0100957)2.60848097
49Tubular atrophy (HP:0000092)2.59485325
50Orchitis (HP:0100796)2.57225411
51Malnutrition (HP:0004395)2.54926891
52Retrobulbar optic neuritis (HP:0100654)2.54655551
53Optic neuritis (HP:0100653)2.54655551
54Tubulointerstitial fibrosis (HP:0005576)2.44432043
55Tetraparesis (HP:0002273)2.43496835
56Hemoptysis (HP:0002105)2.43101597
57Hemorrhage of the eye (HP:0011885)2.40511924
58Progressive neurologic deterioration (HP:0002344)2.35462790
59Complement deficiency (HP:0004431)2.32745253
60Myositis (HP:0100614)2.31129761
61Spontaneous hematomas (HP:0007420)2.31045270
62Tubulointerstitial abnormality (HP:0001969)2.29587940
63Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27717902
64Neuronal loss in central nervous system (HP:0002529)2.27563909
65Glomerulonephritis (HP:0000099)2.25735773
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22718103
67Thin bony cortex (HP:0002753)2.19008860
68Enlarged epiphyses (HP:0010580)2.17985491
69Abnormality of complement system (HP:0005339)2.15989252
70Interstitial pulmonary disease (HP:0006530)2.14134897
71Colitis (HP:0002583)2.13656424
72Gangrene (HP:0100758)2.12163167
73Meningitis (HP:0001287)2.10552801
74Neurofibrillary tangles (HP:0002185)2.09516302
75Personality changes (HP:0000751)2.09132326
76Protuberant abdomen (HP:0001538)2.08973131
77Hepatosplenomegaly (HP:0001433)2.08798709
78Metaphyseal irregularity (HP:0003025)2.08446365
79Autoimmune thrombocytopenia (HP:0001973)2.08371029
80Fatigue (HP:0012378)2.07995340
81Abnormality of the vasculature of the conjunctiva (HP:0008054)2.06959889
82Chronic sinusitis (HP:0011109)2.06223193
83Abnormality of iron homeostasis (HP:0011031)2.05974383
84Widely patent fontanelles and sutures (HP:0004492)2.05712710
85Abnormality of the costochondral junction (HP:0000919)2.03931877
86Spastic tetraparesis (HP:0001285)2.03119135
87Pathologic fracture (HP:0002756)2.02027544
88Peripheral demyelination (HP:0011096)2.01876810
89Apathy (HP:0000741)2.01213520
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.6361574
91Dynein arm defect of respiratory motile cilia (HP:0012255)10.5977034
92Absent/shortened dynein arms (HP:0200106)10.5977034
93Petechiae (HP:0000967)1.99361600
94Retinal atrophy (HP:0001105)1.99348259
95Recurrent skin infections (HP:0001581)1.99051439
96Polyneuropathy (HP:0001271)1.98582792
97Recurrent fungal infections (HP:0002841)1.97850331
98Diminished motivation (HP:0000745)1.97162163
99Impulsivity (HP:0100710)1.96416849
100Thick nail (HP:0001805)1.92714853
101Nephritis (HP:0000123)1.91808316
102Episodic fever (HP:0001954)1.91746477
103Chronic otitis media (HP:0000389)1.91413352
104Prolonged neonatal jaundice (HP:0006579)1.91178157
105Mediastinal lymphadenopathy (HP:0100721)1.89738281
106Acne (HP:0001061)1.89491078
107Pulmonary embolism (HP:0002204)1.89111147
108Dementia (HP:0000726)1.88946322
109Gingivitis (HP:0000230)1.88759667
110Increased IgE level (HP:0003212)1.87200857
111Elevated erythrocyte sedimentation rate (HP:0003565)1.87069250
112Urticaria (HP:0001025)1.86595928
113Tubulointerstitial nephritis (HP:0001970)1.85729136
114Hypercholesterolemia (HP:0003124)1.84607310
115Segmental peripheral demyelination/remyelination (HP:0003481)1.84132478
116Abnormality of macrophages (HP:0004311)1.83935080
117Premature loss of primary teeth (HP:0006323)1.83091614
118Polycythemia (HP:0001901)1.83018315
119Abnormal gallbladder physiology (HP:0012438)1.82830418
120Cholecystitis (HP:0001082)1.82830418
121Gonadotropin excess (HP:0000837)1.81940546
122Glomerulopathy (HP:0100820)1.81393627
123Generalized aminoaciduria (HP:0002909)1.81208551
124Abnormality of transition element cation homeostasis (HP:0011030)1.80302822
125Increased CSF protein (HP:0002922)1.79428066
126Arterial thrombosis (HP:0004420)1.79125986
127Osteolytic defects of the hand bones (HP:0009699)1.77008054
128Osteolytic defects of the phalanges of the hand (HP:0009771)1.77008054
129Periodontitis (HP:0000704)1.75593933
130Absent frontal sinuses (HP:0002688)1.74101318
131Vascular calcification (HP:0004934)1.73858775
132Asymmetric septal hypertrophy (HP:0001670)1.69147597
133Inflammation of the large intestine (HP:0002037)1.68182829
134Abnormal drinking behavior (HP:0030082)1.67841571
135Polydipsia (HP:0001959)1.67841571
136Deformed sella turcica (HP:0002681)1.67498163
137Congenital hepatic fibrosis (HP:0002612)1.66889883
138Keratoconjunctivitis (HP:0001096)1.66687088
139Esophageal varix (HP:0002040)1.65355808
140Upper motor neuron abnormality (HP:0002127)1.65290720
141Amyloidosis (HP:0011034)1.64846220
142Vasculitis (HP:0002633)1.64347176
143Recurrent viral infections (HP:0004429)1.62991732
144Choroideremia (HP:0001139)1.62921476
145J-shaped sella turcica (HP:0002680)1.62551705
146Abnormality of renal excretion (HP:0011036)1.61878597
147* Abnormal spermatogenesis (HP:0008669)1.60467282
148Hypergammaglobulinemia (HP:0010702)1.55458579
149Keratoconjunctivitis sicca (HP:0001097)1.55087895
150Porencephaly (HP:0002132)1.55047433
151Cardiovascular calcification (HP:0011915)1.52542100
152Hematochezia (HP:0002573)1.52069893
153Gastrointestinal inflammation (HP:0004386)1.51942738
154Pulmonary infiltrates (HP:0002113)1.51799505
155Stroke (HP:0001297)1.50202549
156Cerebral inclusion bodies (HP:0100314)1.49722844
157Stage 5 chronic kidney disease (HP:0003774)1.47143872
158Abnormality of the renal cortex (HP:0011035)1.44701705
159Short nail (HP:0001799)1.43791552
160Dyschromatopsia (HP:0007641)1.41954647
161Peritonitis (HP:0002586)1.41597252
162Chronic mucocutaneous candidiasis (HP:0002728)1.40566168
163Recurrent cutaneous fungal infections (HP:0011370)1.40566168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK16.35877884
2PDK45.53941005
3PDK35.53941005
4ICK3.92359991
5PRKD33.71419286
6PDK23.68986649
7DDR23.62232682
8MAP3K143.28318864
9TYK22.59288725
10MAP3K112.47188868
11TBK12.35778530
12EPHB12.25775618
13PTK2B2.18535003
14GRK72.08147237
15NME21.98864929
16IKBKB1.88117243
17RIPK41.79821482
18IKBKE1.78749943
19TAOK11.77520421
20TAOK21.75379373
21WNK41.67526832
22DYRK1B1.59970842
23PRPF4B1.59519604
24JAK11.55552984
25CHUK1.52204091
26IRAK11.50847404
27FGFR41.50793609
28KIT1.44433449
29MAP3K131.43132336
30CDC42BPA1.42685744
31STK381.36531126
32JAK31.36497830
33STK391.30348249
34TNK21.25269381
35MAPK151.22767408
36TRIB31.13335687
37NEK21.12613554
38BLK1.12303197
39EPHA31.11363072
40STK31.10383033
41MOS1.08698857
42CAMK1D1.08547498
43CSF1R1.07960306
44PKN11.06387903
45TXK1.01263201
46FES0.97186922
47ERN10.96247455
48IRAK40.92049776
49PDK10.91454174
50KSR20.91438488
51PLK40.88965005
52FLT30.82871877
53MST1R0.80863113
54PRKAA20.80705787
55CSK0.77826837
56MAP3K100.75415339
57MARK20.72006433
58SIK20.70057686
59WNK10.68758309
60SIK30.68322135
61PTK60.68168092
62ARAF0.67661330
63IRAK30.67488577
64ACVR1B0.66686314
65RPS6KC10.66260090
66RPS6KL10.66260090
67RPS6KA20.65611257
68TAOK30.64558668
69MAP4K10.63709269
70JAK20.61951215
71PDPK10.61162375
72PIM10.60405466
73ZAP700.60388227
74TGFBR20.58713113
75RPS6KA60.56489228
76IRAK20.54974692
77TESK20.54587712
78PRKG20.54250276
79PNCK0.53450560
80CAMK1G0.51893582
81FGFR30.50212916
82DYRK30.49118610
83CDK120.48043468
84LCK0.47833583
85TTN0.47410567
86CDK60.46910706
87DAPK20.45285278
88ADRBK20.44352416
89PRKD20.42651362
90EGFR0.42289490
91NEK90.41257326
92SYK0.40802964
93MAP2K60.40406860
94MAPK70.40326366
95TYRO30.39502150
96PIM20.39357673
97HCK0.37870281
98MAP3K80.37413374
99CAMKK20.37377396
100GRK60.36470234
101PRKCD0.36187342
102STK40.35071731
103PRKCQ0.34996588
104MAPK40.33684371
105BMX0.31655488
106RPS6KA10.30546809
107STK100.30506189
108GSK3A0.30240790
109FGR0.29994838
110MAP3K20.29772800
111MTOR0.29689123
112FYN0.29236618
113MAP2K20.29147411
114MARK30.29080760
115RPS6KA40.28807604
116LATS20.28760889
117PAK40.27486998
118RIPK10.27094741
119PRKAA10.25823920
120PRKCZ0.25819204
121MAP3K30.25003605
122BTK0.24267832
123PAK10.22558631
124MAP2K30.21585306
125ABL10.20481617
126BMPR20.16276707
127MAPKAPK20.16244497
128LYN0.14594553
129MAP3K10.14567479
130MATK0.14004842
131SIK10.12638211
132PAK20.12359973
133PDGFRB0.11661665
134PRKACG0.11635047
135SGK10.09706869
136MAP3K50.09224834
137STK38L0.09134066
138ABL20.08317303

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.10780264
2Staphylococcus aureus infection_Homo sapiens_hsa051502.77649582
3Fatty acid biosynthesis_Homo sapiens_hsa000612.73638759
4Antigen processing and presentation_Homo sapiens_hsa046122.49825869
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.29979289
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07390881
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.00649842
8Osteoclast differentiation_Homo sapiens_hsa043801.95362270
9PPAR signaling pathway_Homo sapiens_hsa033201.95087855
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.91026366
11Leishmaniasis_Homo sapiens_hsa051401.87980716
12Linoleic acid metabolism_Homo sapiens_hsa005911.87762685
13Type I diabetes mellitus_Homo sapiens_hsa049401.85520596
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82276145
15Legionellosis_Homo sapiens_hsa051341.82058753
16Measles_Homo sapiens_hsa051621.76175611
17Asthma_Homo sapiens_hsa053101.72872450
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68346405
19Toxoplasmosis_Homo sapiens_hsa051451.67986990
20Selenocompound metabolism_Homo sapiens_hsa004501.63704596
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.55549187
22Adipocytokine signaling pathway_Homo sapiens_hsa049201.53373941
23Pyruvate metabolism_Homo sapiens_hsa006201.53246324
24TNF signaling pathway_Homo sapiens_hsa046681.48317957
25Complement and coagulation cascades_Homo sapiens_hsa046101.45681687
26Fatty acid degradation_Homo sapiens_hsa000711.45558534
27Propanoate metabolism_Homo sapiens_hsa006401.45502136
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45260465
29B cell receptor signaling pathway_Homo sapiens_hsa046621.45113375
30Influenza A_Homo sapiens_hsa051641.44709194
31Dorso-ventral axis formation_Homo sapiens_hsa043201.44288126
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42909631
33Vitamin B6 metabolism_Homo sapiens_hsa007501.40051496
34Prion diseases_Homo sapiens_hsa050201.39344252
35Allograft rejection_Homo sapiens_hsa053301.38347678
36Graft-versus-host disease_Homo sapiens_hsa053321.33646618
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29313700
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26888647
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24951865
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.23778532
41Hematopoietic cell lineage_Homo sapiens_hsa046401.23727431
42ABC transporters_Homo sapiens_hsa020101.23264321
43Malaria_Homo sapiens_hsa051441.20866533
44Fructose and mannose metabolism_Homo sapiens_hsa000511.09218930
45Fatty acid metabolism_Homo sapiens_hsa012121.08113617
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07506024
47Glycerolipid metabolism_Homo sapiens_hsa005611.06777069
48African trypanosomiasis_Homo sapiens_hsa051431.05784582
49Herpes simplex infection_Homo sapiens_hsa051681.05625468
50Tuberculosis_Homo sapiens_hsa051521.05405707
51Apoptosis_Homo sapiens_hsa042101.03446304
52Fat digestion and absorption_Homo sapiens_hsa049751.03332183
53Glucagon signaling pathway_Homo sapiens_hsa049221.02117516
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01546315
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.01066113
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99703488
57Pertussis_Homo sapiens_hsa051330.97171207
58Mineral absorption_Homo sapiens_hsa049780.94131914
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92186330
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90422159
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87256412
62Amoebiasis_Homo sapiens_hsa051460.87028056
63Other glycan degradation_Homo sapiens_hsa005110.86785559
64Pentose phosphate pathway_Homo sapiens_hsa000300.85707115
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.84134772
66Ether lipid metabolism_Homo sapiens_hsa005650.83191580
67Salmonella infection_Homo sapiens_hsa051320.82008289
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80991696
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80053656
70Bladder cancer_Homo sapiens_hsa052190.80024374
71VEGF signaling pathway_Homo sapiens_hsa043700.79355740
72Rheumatoid arthritis_Homo sapiens_hsa053230.79114932
73Lysosome_Homo sapiens_hsa041420.78834386
74Hepatitis B_Homo sapiens_hsa051610.78736418
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76920971
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75174186
77Arginine biosynthesis_Homo sapiens_hsa002200.74104399
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72517704
79Shigellosis_Homo sapiens_hsa051310.72344686
80Bile secretion_Homo sapiens_hsa049760.71505228
81Chemokine signaling pathway_Homo sapiens_hsa040620.70277590
82Phenylalanine metabolism_Homo sapiens_hsa003600.70190888
83Caffeine metabolism_Homo sapiens_hsa002320.70179264
84Insulin resistance_Homo sapiens_hsa049310.69425415
85Peroxisome_Homo sapiens_hsa041460.69120286
86Collecting duct acid secretion_Homo sapiens_hsa049660.68249432
87Prolactin signaling pathway_Homo sapiens_hsa049170.68129382
88Phagosome_Homo sapiens_hsa041450.66854400
89Chemical carcinogenesis_Homo sapiens_hsa052040.66492757
90Renin-angiotensin system_Homo sapiens_hsa046140.66122392
91Endocytosis_Homo sapiens_hsa041440.65718195
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64822108
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63501045
94T cell receptor signaling pathway_Homo sapiens_hsa046600.60991153
95Tryptophan metabolism_Homo sapiens_hsa003800.60860493
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60463673
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.60377057
98Notch signaling pathway_Homo sapiens_hsa043300.58545626
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.57877854
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.56813072
101Sphingolipid metabolism_Homo sapiens_hsa006000.55363503
102Acute myeloid leukemia_Homo sapiens_hsa052210.55195874
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53764802
104Autoimmune thyroid disease_Homo sapiens_hsa053200.53021636
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51021315
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50623422
107Viral myocarditis_Homo sapiens_hsa054160.50077731
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49349594
109Hepatitis C_Homo sapiens_hsa051600.47423433
110Primary immunodeficiency_Homo sapiens_hsa053400.46450333
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45654714
112Galactose metabolism_Homo sapiens_hsa000520.44861256
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.44435078
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44032836
115Epstein-Barr virus infection_Homo sapiens_hsa051690.43628923
116Small cell lung cancer_Homo sapiens_hsa052220.42817791
117Platelet activation_Homo sapiens_hsa046110.42710048
118Glutathione metabolism_Homo sapiens_hsa004800.42409770
119Viral carcinogenesis_Homo sapiens_hsa052030.41574548
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39202201
121HIF-1 signaling pathway_Homo sapiens_hsa040660.38479918
122Systemic lupus erythematosus_Homo sapiens_hsa053220.37754105
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.37045327
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36948520
125Histidine metabolism_Homo sapiens_hsa003400.36615924
126Type II diabetes mellitus_Homo sapiens_hsa049300.35817501
127Carbon metabolism_Homo sapiens_hsa012000.35736216
128Chronic myeloid leukemia_Homo sapiens_hsa052200.34976374
129Arachidonic acid metabolism_Homo sapiens_hsa005900.34537993
130Pancreatic cancer_Homo sapiens_hsa052120.30434525
131Vibrio cholerae infection_Homo sapiens_hsa051100.29342667
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27816445
133MAPK signaling pathway_Homo sapiens_hsa040100.26787210
134Renal cell carcinoma_Homo sapiens_hsa052110.26232841
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25995304
136Estrogen signaling pathway_Homo sapiens_hsa049150.24768016
137GnRH signaling pathway_Homo sapiens_hsa049120.24129079
138HTLV-I infection_Homo sapiens_hsa051660.22271265

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