ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of short-term neuronal synaptic plasticity (GO:0048172)	8.14040185
2	synaptic vesicle docking involved in exocytosis (GO:0016081)	7.58177675
3	somatic hypermutation of immunoglobulin genes (GO:0016446)	7.42408126
4	somatic diversification of immune receptors via somatic mutation (GO:0002566)	7.42408126
5	regulation of helicase activity (GO:0051095)	7.35844391
6	opioid receptor signaling pathway (GO:0038003)	6.96976012
7	positive regulation of neurotransmitter secretion (GO:0001956)	6.88951506
8	meiotic chromosome segregation (GO:0045132)	6.24236931
9	epithelial cilium movement (GO:0003351)	5.68742479
10	resolution of meiotic recombination intermediates (GO:0000712)	5.43130227
11	positive regulation of megakaryocyte differentiation (GO:0045654)	5.25704295
12	positive regulation of neurotransmitter transport (GO:0051590)	5.06147974
13	ncRNA 3-end processing (GO:0043628)	5.00310074
14	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	4.89201227
15	positive regulation of smoothened signaling pathway (GO:0045880)	4.88727234
16	innervation (GO:0060384)	4.80667244
17	embryonic skeletal joint morphogenesis (GO:0060272)	4.79470678
18	single strand break repair (GO:0000012)	4.57418096
19	inner mitochondrial membrane organization (GO:0007007)	4.51408992
20	synapsis (GO:0007129)	4.48726119
21	anterograde synaptic vesicle transport (GO:0048490)	4.48713389
22	DNA strand renaturation (GO:0000733)	4.41127314
23	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	4.39131582
24	response to pheromone (GO:0019236)	4.38141602
25	cellular response to pH (GO:0071467)	4.33515491
26	intra-S DNA damage checkpoint (GO:0031573)	4.32292167
27	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	4.20334122
28	cilium movement (GO:0003341)	4.15513253
29	galactose catabolic process (GO:0019388)	4.14450288
30	response to UV-B (GO:0010224)	4.07419688
31	chondroitin sulfate catabolic process (GO:0030207)	4.05578604
32	negative regulation of DNA recombination (GO:0045910)	4.04527870
33	histone H2A acetylation (GO:0043968)	4.04299740
34	cellular response to oxygen radical (GO:0071450)	4.04070518
35	removal of superoxide radicals (GO:0019430)	4.04070518
36	cellular response to superoxide (GO:0071451)	4.04070518
37	non-recombinational repair (GO:0000726)	3.86735708
38	double-strand break repair via nonhomologous end joining (GO:0006303)	3.86735708
39	regulation of MHC class II biosynthetic process (GO:0045346)	3.86490452
40	pyrimidine dimer repair (GO:0006290)	3.73490764
41	anterograde axon cargo transport (GO:0008089)	3.64028358
42	protein localization to peroxisome (GO:0072662)	3.57566770
43	protein targeting to peroxisome (GO:0006625)	3.57566770
44	establishment of protein localization to peroxisome (GO:0072663)	3.57566770
45	regulation of mitotic spindle checkpoint (GO:1903504)	3.56195223
46	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.56195223
47	snRNA processing (GO:0016180)	3.54782188
48	arginine catabolic process (GO:0006527)	3.54410552
49	response to superoxide (GO:0000303)	3.50158752
50	somite development (GO:0061053)	3.47532513
51	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.43642299
52	ATP synthesis coupled proton transport (GO:0015986)	3.43642299
53	response to oxygen radical (GO:0000305)	3.40246699
54	fatty acid homeostasis (GO:0055089)	3.33254323
55	mismatch repair (GO:0006298)	3.26656111
56	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	3.25926730
57	DNA double-strand break processing (GO:0000729)	3.21120662
58	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.20796111
59	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.17353998
60	snRNA metabolic process (GO:0016073)	3.14480178
61	peroxisomal transport (GO:0043574)	3.12725762
62	cellular response to cholesterol (GO:0071397)	3.11967424
63	ovulation from ovarian follicle (GO:0001542)	3.11185517
64	hyaluronan catabolic process (GO:0030214)	3.10393820
65	thalamus development (GO:0021794)	3.09952397
66	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.09743281
67	anatomical structure regression (GO:0060033)	3.08275908
68	cellular response to sterol (GO:0036315)	3.05588819
69	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.00362777
70	regulation of synaptic vesicle exocytosis (GO:2000300)	2.99181536
71	positive regulation of vascular permeability (GO:0043117)	2.98738491
72	axoneme assembly (GO:0035082)	2.90729346
73	generation of neurons (GO:0048699)	2.85836724
74	metaphase plate congression (GO:0051310)	2.84787302
75	C-terminal protein amino acid modification (GO:0018410)	2.80567915
76	lipid particle organization (GO:0034389)	2.77368688
77	genitalia morphogenesis (GO:0035112)	2.74271658
78	hematopoietic stem cell proliferation (GO:0071425)	2.71198178
79	regulation of bile acid biosynthetic process (GO:0070857)	2.67651860
80	limb bud formation (GO:0060174)	2.66722612
81	regulation of cAMP-dependent protein kinase activity (GO:2000479)	2.65104917
82	adult heart development (GO:0007512)	2.64941453
83	preassembly of GPI anchor in ER membrane (GO:0016254)	2.63681810
84	regulation of histone H3-K9 methylation (GO:0051570)	2.59527269
85	digestive tract morphogenesis (GO:0048546)	2.57669589
86	macroautophagy (GO:0016236)	2.57268014
87	intracellular protein transmembrane transport (GO:0065002)	2.55844166
88	L-methionine salvage (GO:0071267)	2.54281189
89	L-methionine biosynthetic process (GO:0071265)	2.54281189
90	amino acid salvage (GO:0043102)	2.54281189
91	termination of RNA polymerase III transcription (GO:0006386)	2.54026466
92	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.54026466
93	negative regulation of JUN kinase activity (GO:0043508)	2.52624687
94	negative regulation of macroautophagy (GO:0016242)	2.52118963
95	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.50850594
96	regulation of collateral sprouting (GO:0048670)	2.49901742
97	rRNA catabolic process (GO:0016075)	2.49807275
98	positive regulation of neurological system process (GO:0031646)	2.47214581
99	cullin deneddylation (GO:0010388)	2.44781537
100	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.44732366

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.85428973
2	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.40259297
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.38428732
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.14986613
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.73124822
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.72702658
7	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.58507130
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.56781209
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.43384268
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.34486293
11	E2F7_22180533_ChIP-Seq_HELA_Human	2.31674942
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.27939947
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.21241925
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.21137040
15	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.15568156
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.08341041
17	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.06633985
18	BCAT_22108803_ChIP-Seq_LS180_Human	2.04275035
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.03428342
20	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.02405812
21	EWS_26573619_Chip-Seq_HEK293_Human	2.02277592
22	FUS_26573619_Chip-Seq_HEK293_Human	1.99018634
23	P300_19829295_ChIP-Seq_ESCs_Human	1.90509617
24	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.88460255
25	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.80205021
26	AR_21572438_ChIP-Seq_LNCaP_Human	1.79055015
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.72449066
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68157106
29	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.63798861
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.62802637
31	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.62559141
32	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.61089185
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.59846444
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.59342627
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.57472395
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.55195133
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.47550746
38	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.47056802
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.45688103
40	AR_25329375_ChIP-Seq_VCAP_Human	1.41154068
41	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.38972720
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38798284
43	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36627059
44	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.36481843
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36245534
46	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.34739273
47	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.33155210
48	NCOR_22424771_ChIP-Seq_293T_Human	1.32970802
49	HOXB7_26014856_ChIP-Seq_BT474_Human	1.32813439
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30833242
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30833242
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29970514
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.29970514
54	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29579511
55	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25707768
56	DCP1A_22483619_ChIP-Seq_HELA_Human	1.25157856
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23242143
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.21775808
59	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21177647
60	AHR_22903824_ChIP-Seq_MCF-7_Human	1.20231744
61	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.20181895
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19917125
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.19041141
64	ER_23166858_ChIP-Seq_MCF-7_Human	1.18292019
65	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.16991367
66	CDX2_22108803_ChIP-Seq_LS180_Human	1.16846010
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15435007
68	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.14920094
69	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.14541600
70	TCF4_23295773_ChIP-Seq_U87_Human	1.13589502
71	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10670477
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.10162188
73	TP53_22573176_ChIP-Seq_HFKS_Human	1.07773352
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06846405
75	STAT3_23295773_ChIP-Seq_U87_Human	1.05672677
76	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.03667991
77	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02999950
78	CBP_20019798_ChIP-Seq_JUKART_Human	1.02999950
79	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.01798787
80	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01716350
81	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.01232673
82	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01205730
83	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00317483
84	AR_21909140_ChIP-Seq_LNCAP_Human	0.97357305
85	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.97329736
86	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.96000581
87	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.95010769
88	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.94736553
89	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.93655630
90	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.91756415
91	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.91361268
92	RUNX2_22187159_ChIP-Seq_PCA_Human	0.90385651
93	P300_18555785_Chip-Seq_ESCs_Mouse	0.90053603
94	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.88613582
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.88354763
96	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.88318648
97	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.88161376
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88054720
99	FOXP3_21729870_ChIP-Seq_TREG_Human	0.87781145
100	IRF1_19129219_ChIP-ChIP_H3396_Human	0.86381015

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	6.76262598
2	MP0003136_yellow_coat_color	3.73172724
3	MP0008877_abnormal_DNA_methylation	3.33832243
4	MP0002102_abnormal_ear_morphology	3.33817030
5	MP0000372_irregular_coat_pigmentation	3.16940320
6	MP0008058_abnormal_DNA_repair	3.14366607
7	MP0004147_increased_porphyrin_level	2.71425859
8	MP0005310_abnormal_salivary_gland	2.39027340
9	MP0003122_maternal_imprinting	2.24787466
10	MP0000015_abnormal_ear_pigmentation	2.24712065
11	MP0010030_abnormal_orbit_morphology	2.24614028
12	MP0001529_abnormal_vocalization	2.19453620
13	MP0005174_abnormal_tail_pigmentation	2.19365542
14	MP0002089_abnormal_postnatal_growth/wei	2.13280034
15	MP0009697_abnormal_copulation	2.02269287
16	MP0000462_abnormal_digestive_system	2.00134222
17	MP0003941_abnormal_skin_development	1.95033444
18	MP0002254_reproductive_system_inflammat	1.87070671
19	MP0008872_abnormal_physiological_respon	1.77029403
20	MP0003121_genomic_imprinting	1.75151025
21	MP0002090_abnormal_vision	1.72682578
22	MP0005075_abnormal_melanosome_morpholog	1.70928547
23	MP0000631_abnormal_neuroendocrine_gland	1.66738363
24	MP0009745_abnormal_behavioral_response	1.62213381
25	MP0003937_abnormal_limbs/digits/tail_de	1.56036500
26	MP0003115_abnormal_respiratory_system	1.55916409
27	MP0003283_abnormal_digestive_organ	1.53575643
28	MP0003011_delayed_dark_adaptation	1.52230031
29	MP0005408_hypopigmentation	1.48132857
30	MP0004133_heterotaxia	1.46434599
31	MP0001293_anophthalmia	1.45309793
32	MP0005171_absent_coat_pigmentation	1.39162522
33	MP0003111_abnormal_nucleus_morphology	1.37606643
34	MP0002557_abnormal_social/conspecific_i	1.30569370
35	MP0002282_abnormal_trachea_morphology	1.29862401
36	MP0005083_abnormal_biliary_tract	1.23379020
37	MP0004381_abnormal_hair_follicle	1.22366341
38	MP0002638_abnormal_pupillary_reflex	1.18486755
39	MP0003942_abnormal_urinary_system	1.18000388
40	MP0000566_synostosis	1.16990292
41	MP0005220_abnormal_exocrine_pancreas	1.14626472
42	MP0005266_abnormal_metabolism	1.14548952
43	MP0005253_abnormal_eye_physiology	1.12761242
44	MP0002933_joint_inflammation	1.09843714
45	MP0005551_abnormal_eye_electrophysiolog	1.08523494
46	MP0005391_vision/eye_phenotype	1.05784938
47	MP0002938_white_spotting	1.05148051
48	MP0001486_abnormal_startle_reflex	1.01769772
49	MP0002064_seizures	1.01625859
50	MP0005409_darkened_coat_color	1.01574250
51	MP0009672_abnormal_birth_weight	1.01097146
52	MP0001970_abnormal_pain_threshold	1.00951185
53	MP0002909_abnormal_adrenal_gland	1.00664686
54	MP0003119_abnormal_digestive_system	1.00408276
55	MP0002132_abnormal_respiratory_system	0.98440130
56	MP0003755_abnormal_palate_morphology	0.97384030
57	MP0010094_abnormal_chromosome_stability	0.96211296
58	MP0003077_abnormal_cell_cycle	0.96109918
59	MP0004264_abnormal_extraembryonic_tissu	0.94643932
60	MP0001929_abnormal_gametogenesis	0.92460735
61	MP0002092_abnormal_eye_morphology	0.92065550
62	MP0002876_abnormal_thyroid_physiology	0.91534974
63	MP0001286_abnormal_eye_development	0.91241158
64	MP0002233_abnormal_nose_morphology	0.90696846
65	MP0004957_abnormal_blastocyst_morpholog	0.90506359
66	MP0002751_abnormal_autonomic_nervous	0.90368128
67	MP0009046_muscle_twitch	0.89778604
68	MP0001299_abnormal_eye_distance/	0.88579695
69	MP0001986_abnormal_taste_sensitivity	0.88261810
70	MP0002084_abnormal_developmental_patter	0.87914279
71	MP0000383_abnormal_hair_follicle	0.87469546
72	MP0002095_abnormal_skin_pigmentation	0.86453805
73	MP0002210_abnormal_sex_determination	0.84367184
74	MP0001984_abnormal_olfaction	0.84153593
75	MP0003567_abnormal_fetal_cardiomyocyte	0.83335612
76	MP0000537_abnormal_urethra_morphology	0.82934898
77	MP0001145_abnormal_male_reproductive	0.82309195
78	MP0001119_abnormal_female_reproductive	0.81568476
79	MP0002085_abnormal_embryonic_tissue	0.81244956
80	MP0002736_abnormal_nociception_after	0.81124294
81	MP0005377_hearing/vestibular/ear_phenot	0.80465525
82	MP0003878_abnormal_ear_physiology	0.80465525
83	MP0003861_abnormal_nervous_system	0.80127839
84	MP0003943_abnormal_hepatobiliary_system	0.80018944
85	MP0003718_maternal_effect	0.79575317
86	MP0000653_abnormal_sex_gland	0.79255284
87	MP0001697_abnormal_embryo_size	0.79005039
88	MP0006036_abnormal_mitochondrial_physio	0.77035856
89	MP0010386_abnormal_urinary_bladder	0.74547034
90	MP0003698_abnormal_male_reproductive	0.73492485
91	MP0004924_abnormal_behavior	0.73212420
92	MP0005386_behavior/neurological_phenoty	0.73212420
93	MP0001324_abnormal_eye_pigmentation	0.71898220
94	MP0005332_abnormal_amino_acid	0.71302066
95	MP0005084_abnormal_gallbladder_morpholo	0.69771668
96	MP0002116_abnormal_craniofacial_bone	0.67963447
97	MP0002837_dystrophic_cardiac_calcinosis	0.67914654
98	MP0003186_abnormal_redox_activity	0.67396643
99	MP0002697_abnormal_eye_size	0.67244436
100	MP0002067_abnormal_sensory_capabilities	0.67013812

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Colon cancer (HP:0003003)	8.29680072
2	Submucous cleft hard palate (HP:0000176)	6.37288803
3	Ependymoma (HP:0002888)	5.29676686
4	Mucopolysacchariduria (HP:0008155)	4.46065184
5	Urinary glycosaminoglycan excretion (HP:0003541)	4.46065184
6	Abnormality of polysaccharide metabolism (HP:0011012)	4.18934546
7	Abnormality of glycosaminoglycan metabolism (HP:0004371)	4.18934546
8	Abnormality of mucopolysaccharide metabolism (HP:0011020)	4.18934546
9	Neoplasm of the adrenal cortex (HP:0100641)	3.67792229
10	Agnosia (HP:0010524)	3.65296118
11	Astrocytoma (HP:0009592)	3.61419913
12	Abnormality of the astrocytes (HP:0100707)	3.61419913
13	Neoplasm of the oral cavity (HP:0100649)	3.48346998
14	Bifid tongue (HP:0010297)	3.38197987
15	Poikiloderma (HP:0001029)	3.35112107
16	Pancreatic islet-cell hyperplasia (HP:0004510)	3.34276093
17	Vacuolated lymphocytes (HP:0001922)	3.32400719
18	Abnormal gallbladder physiology (HP:0012438)	3.27180554
19	Cholecystitis (HP:0001082)	3.27180554
20	Cervical subluxation (HP:0003308)	3.21307641
21	Brushfield spots (HP:0001088)	3.20445485
22	Disproportionate short-trunk short stature (HP:0003521)	3.04734706
23	Beaking of vertebral bodies (HP:0004568)	3.03529064
24	Abnormality of the pancreatic islet cells (HP:0006476)	2.95963650
25	Abnormality of endocrine pancreas physiology (HP:0012093)	2.95963650
26	Prostate neoplasm (HP:0100787)	2.89859182
27	Glioma (HP:0009733)	2.84504848
28	Pancreatic cysts (HP:0001737)	2.83249501
29	Breast carcinoma (HP:0003002)	2.79061388
30	Focal motor seizures (HP:0011153)	2.77126143
31	Medulloblastoma (HP:0002885)	2.62563945
32	Abnormality of the labia minora (HP:0012880)	2.61176507
33	Neoplasm of the liver (HP:0002896)	2.53651740
34	Hypoplasia of the odontoid process (HP:0003311)	2.53165446
35	Abnormality of methionine metabolism (HP:0010901)	2.51403195
36	Rhabdomyosarcoma (HP:0002859)	2.50482314
37	Cerebellar dysplasia (HP:0007033)	2.47723570
38	Intestinal atresia (HP:0011100)	2.46654755
39	Neoplasm of the adrenal gland (HP:0100631)	2.44304445
40	High anterior hairline (HP:0009890)	2.43259426
41	Molar tooth sign on MRI (HP:0002419)	2.41118289
42	Abnormality of midbrain morphology (HP:0002418)	2.41118289
43	Late onset (HP:0003584)	2.39021835
44	True hermaphroditism (HP:0010459)	2.34819546
45	Amaurosis fugax (HP:0100576)	2.22321064
46	Short tibia (HP:0005736)	2.19851810
47	Pancreatic fibrosis (HP:0100732)	2.19416722
48	Ulnar deviation of the wrist (HP:0003049)	2.16251637
49	Benign neoplasm of the central nervous system (HP:0100835)	2.14507827
50	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.13803040
51	Type II lissencephaly (HP:0007260)	2.12792228
52	Bilateral microphthalmos (HP:0007633)	2.10615185
53	Cellular immunodeficiency (HP:0005374)	2.08883977
54	Neoplasm of striated muscle (HP:0009728)	2.04911424
55	Gaze-evoked nystagmus (HP:0000640)	2.03960122
56	Methylmalonic acidemia (HP:0002912)	2.02378413
57	Angiofibromas (HP:0010615)	2.01854020
58	Adenoma sebaceum (HP:0009720)	2.01854020
59	Sensory axonal neuropathy (HP:0003390)	1.96775173
60	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.94768931
61	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.93405507
62	Hypoplasia of the fovea (HP:0007750)	1.93405507
63	Bifid uvula (HP:0000193)	1.93225449
64	Hyperglycinemia (HP:0002154)	1.93175511
65	Unsteady gait (HP:0002317)	1.92796491
66	Abnormality of the salivary glands (HP:0010286)	1.92735549
67	Neoplasm of the colon (HP:0100273)	1.92172618
68	Large for gestational age (HP:0001520)	1.91404821
69	Female pseudohermaphroditism (HP:0010458)	1.91269586
70	Hypoplastic nipples (HP:0002557)	1.89384202
71	Congenital stationary night blindness (HP:0007642)	1.89236445
72	Generalized myoclonic seizures (HP:0002123)	1.89236404
73	Bicornuate uterus (HP:0000813)	1.84625271
74	Abnormality of the odontoid process (HP:0003310)	1.84605304
75	Thickened nuchal skin fold (HP:0000474)	1.83832178
76	Cystic liver disease (HP:0006706)	1.80214133
77	Double outlet right ventricle (HP:0001719)	1.78365840
78	Congenital malformation of the right heart (HP:0011723)	1.78365840
79	Broad palm (HP:0001169)	1.76662538
80	Anophthalmia (HP:0000528)	1.75322463
81	Attenuation of retinal blood vessels (HP:0007843)	1.73505725
82	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	1.72916759
83	Vertebral hypoplasia (HP:0008417)	1.72916759
84	Albinism (HP:0001022)	1.71394881
85	Nephroblastoma (Wilms tumor) (HP:0002667)	1.70691624
86	Abnormality of the fovea (HP:0000493)	1.70192049
87	Epiphyseal stippling (HP:0010655)	1.69882486
88	Abnormality of the acetabulum (HP:0003170)	1.69391982
89	Enlarged kidneys (HP:0000105)	1.68729123
90	Optic disc pallor (HP:0000543)	1.68566483
91	Partial agenesis of the corpus callosum (HP:0001338)	1.66691260
92	Hepatocellular carcinoma (HP:0001402)	1.66264543
93	Progressive neurologic deterioration (HP:0002344)	1.65752388
94	Subacute progressive viral hepatitis (HP:0006572)	1.65167882
95	Abnormal lung lobation (HP:0002101)	1.64718014
96	Triphalangeal thumb (HP:0001199)	1.64440172
97	Duplicated collecting system (HP:0000081)	1.62407096
98	Broad alveolar ridges (HP:0000187)	1.59294030
99	Broad-based gait (HP:0002136)	1.59166921
100	Embryonal renal neoplasm (HP:0011794)	1.57988660

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	6.02324594
2	ADRBK2	5.33213738
3	TAF1	5.21706230
4	SMG1	4.35798633
5	NUAK1	4.26906384
6	MAP4K2	3.05762215
7	TRIM28	2.61185874
8	MAPKAPK5	2.28930432
9	DYRK3	2.27551190
10	PBK	2.15641760
11	TNIK	2.15201279
12	VRK1	1.97958412
13	CASK	1.86165948
14	CSNK1G1	1.83158930
15	CSNK1G3	1.66358591
16	AKT3	1.64244900
17	CSNK1A1L	1.62539696
18	CDC7	1.56182111
19	FRK	1.48696671
20	BMPR1B	1.34876991
21	NME1	1.32416556
22	PIK3CG	1.32388699
23	ACVR1B	1.26601557
24	PLK3	1.24414942
25	CSNK1G2	1.22152122
26	CLK1	1.21666311
27	CDK9	1.21410497
28	WEE1	1.19954549
29	ERBB3	1.17093795
30	GRK5	1.15879718
31	TGFBR1	1.12022145
32	PRKCI	1.07076520
33	MAP3K2	1.00961279
34	DAPK1	0.98406789
35	MELK	0.97820897
36	SIK3	0.90787762
37	MAP3K12	0.87109698
38	DYRK2	0.87072289
39	NTRK3	0.80500337
40	DYRK1A	0.80347241
41	TSSK6	0.75875668
42	WNK3	0.75867705
43	MKNK2	0.74854771
44	LATS1	0.67688410
45	EPHB2	0.67587358
46	EIF2AK2	0.66190650
47	PRKAA2	0.65929191
48	PNCK	0.65763883
49	TNK2	0.64286467
50	FGFR2	0.64217806
51	SIK2	0.61831041
52	STK39	0.59141872
53	TTK	0.58805780
54	PAK3	0.56937836
55	PASK	0.55304711
56	CHEK2	0.55203662
57	PIK3CA	0.54805071
58	STK4	0.54155628
59	OXSR1	0.53717023
60	PLK4	0.51849777
61	BRSK2	0.50653708
62	STK11	0.49856825
63	BRD4	0.49850712
64	DAPK3	0.48763228
65	STK3	0.47545628
66	BCR	0.47254870
67	PDK2	0.46015890
68	PLK2	0.45872463
69	CAMK1G	0.45595035
70	MAPKAPK3	0.45354683
71	EEF2K	0.44712979
72	KSR1	0.44451690
73	FER	0.43732729
74	PRKAA1	0.43593647
75	NLK	0.43364039
76	TRPM7	0.42189356
77	BRSK1	0.41651311
78	HIPK2	0.34901198
79	INSRR	0.34774811
80	MKNK1	0.34133129
81	TGFBR2	0.30726929
82	CDK7	0.30120954
83	YES1	0.30112147
84	FGFR1	0.29951971
85	EPHA4	0.27935857
86	CAMK1D	0.27723602
87	PRKCH	0.27433979
88	NEK2	0.27219140
89	ATR	0.26837126
90	PINK1	0.26718317
91	MAP3K4	0.25803151
92	NTRK2	0.24663148
93	PLK1	0.24511881
94	PRKCG	0.23179566
95	RPS6KB2	0.22969030
96	CHEK1	0.22854832
97	GSK3A	0.20396931
98	GRK1	0.18615616
99	ZAK	0.18344080
100	ERBB2	0.16267899

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan degradation_Homo sapiens_hsa00531	4.82913050
2	Non-homologous end-joining_Homo sapiens_hsa03450	4.57197211
3	Basal cell carcinoma_Homo sapiens_hsa05217	3.40516195
4	Hedgehog signaling pathway_Homo sapiens_hsa04340	3.08890342
5	Proteasome_Homo sapiens_hsa03050	2.74995274
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.61023075
7	Protein export_Homo sapiens_hsa03060	2.55025880
8	Mismatch repair_Homo sapiens_hsa03430	2.50263710
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.49866012
10	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.37140850
11	Homologous recombination_Homo sapiens_hsa03440	2.34271068
12	Sulfur metabolism_Homo sapiens_hsa00920	2.07968954
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.00555960
14	RNA degradation_Homo sapiens_hsa03018	1.96781701
15	Steroid biosynthesis_Homo sapiens_hsa00100	1.96126452
16	RNA polymerase_Homo sapiens_hsa03020	1.90161414
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.71587910
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.70729348
19	Propanoate metabolism_Homo sapiens_hsa00640	1.57246347
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.55139551
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.46943320
22	Base excision repair_Homo sapiens_hsa03410	1.46004113
23	Peroxisome_Homo sapiens_hsa04146	1.40829418
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.36538872
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.31323359
26	Lysine degradation_Homo sapiens_hsa00310	1.26920031
27	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.26902584
28	Regulation of autophagy_Homo sapiens_hsa04140	1.26557467
29	Glutathione metabolism_Homo sapiens_hsa00480	1.23287236
30	Phototransduction_Homo sapiens_hsa04744	1.22556145
31	Parkinsons disease_Homo sapiens_hsa05012	1.21881571
32	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.15606115
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.13330108
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.13205230
35	Huntingtons disease_Homo sapiens_hsa05016	1.12918466
36	One carbon pool by folate_Homo sapiens_hsa00670	1.10963793
37	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.10857176
38	RNA transport_Homo sapiens_hsa03013	1.10360044
39	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.07378518
40	Circadian rhythm_Homo sapiens_hsa04710	1.05491498
41	Other glycan degradation_Homo sapiens_hsa00511	0.93882115
42	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.92472310
43	Thyroid cancer_Homo sapiens_hsa05216	0.89799299
44	Caffeine metabolism_Homo sapiens_hsa00232	0.83332509
45	Colorectal cancer_Homo sapiens_hsa05210	0.82753783
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.81654434
47	Olfactory transduction_Homo sapiens_hsa04740	0.80111101
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.78933489
49	Linoleic acid metabolism_Homo sapiens_hsa00591	0.78540817
50	Pyruvate metabolism_Homo sapiens_hsa00620	0.76377910
51	Purine metabolism_Homo sapiens_hsa00230	0.72954337
52	Butanoate metabolism_Homo sapiens_hsa00650	0.72339095
53	Alzheimers disease_Homo sapiens_hsa05010	0.72208131
54	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.67928282
55	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.66728435
56	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.66395097
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.66175928
58	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.63549045
59	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.63014837
60	Fatty acid elongation_Homo sapiens_hsa00062	0.62887274
61	Galactose metabolism_Homo sapiens_hsa00052	0.58477076
62	Tryptophan metabolism_Homo sapiens_hsa00380	0.56263396
63	Metabolic pathways_Homo sapiens_hsa01100	0.55618479
64	Mineral absorption_Homo sapiens_hsa04978	0.55163707
65	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.54653782
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51848075
67	Nitrogen metabolism_Homo sapiens_hsa00910	0.50802751
68	Insulin secretion_Homo sapiens_hsa04911	0.50356554
69	Glucagon signaling pathway_Homo sapiens_hsa04922	0.49991707
70	Cell cycle_Homo sapiens_hsa04110	0.49805345
71	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.49528122
72	Carbon metabolism_Homo sapiens_hsa01200	0.48311305
73	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.44127873
74	Retinol metabolism_Homo sapiens_hsa00830	0.43051769
75	p53 signaling pathway_Homo sapiens_hsa04115	0.40471087
76	Lysosome_Homo sapiens_hsa04142	0.40235372
77	Adherens junction_Homo sapiens_hsa04520	0.38603153
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37115208
79	Pyrimidine metabolism_Homo sapiens_hsa00240	0.36152311
80	Nucleotide excision repair_Homo sapiens_hsa03420	0.35595010
81	Wnt signaling pathway_Homo sapiens_hsa04310	0.35099795
82	Pancreatic secretion_Homo sapiens_hsa04972	0.34202876
83	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.32898862
84	Endometrial cancer_Homo sapiens_hsa05213	0.31911748
85	Chemical carcinogenesis_Homo sapiens_hsa05204	0.30715543
86	GABAergic synapse_Homo sapiens_hsa04727	0.30175316
87	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.29819126
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.28916498
89	Hippo signaling pathway_Homo sapiens_hsa04390	0.28683286
90	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.28466295
91	Ribosome_Homo sapiens_hsa03010	0.28447393
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.28386172
93	Pathways in cancer_Homo sapiens_hsa05200	0.27351641
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.24719298
95	Folate biosynthesis_Homo sapiens_hsa00790	0.24460223
96	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.24036232
97	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.23321946
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.22645412
99	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.22633438
100	Collecting duct acid secretion_Homo sapiens_hsa04966	0.21541469

ZMYND19P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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