ZMYND19P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)8.14040185
2synaptic vesicle docking involved in exocytosis (GO:0016081)7.58177675
3somatic diversification of immune receptors via somatic mutation (GO:0002566)7.42408126
4somatic hypermutation of immunoglobulin genes (GO:0016446)7.42408126
5regulation of helicase activity (GO:0051095)7.35844391
6opioid receptor signaling pathway (GO:0038003)6.96976012
7positive regulation of neurotransmitter secretion (GO:0001956)6.88951506
8meiotic chromosome segregation (GO:0045132)6.24236931
9epithelial cilium movement (GO:0003351)5.68742479
10resolution of meiotic recombination intermediates (GO:0000712)5.43130227
11positive regulation of megakaryocyte differentiation (GO:0045654)5.25704295
12positive regulation of neurotransmitter transport (GO:0051590)5.06147974
13ncRNA 3-end processing (GO:0043628)5.00310074
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.89201227
15positive regulation of smoothened signaling pathway (GO:0045880)4.88727234
16innervation (GO:0060384)4.80667244
17embryonic skeletal joint morphogenesis (GO:0060272)4.79470678
18single strand break repair (GO:0000012)4.57418096
19inner mitochondrial membrane organization (GO:0007007)4.51408992
20synapsis (GO:0007129)4.48726119
21anterograde synaptic vesicle transport (GO:0048490)4.48713389
22DNA strand renaturation (GO:0000733)4.41127314
23positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.39131582
24response to pheromone (GO:0019236)4.38141602
25cellular response to pH (GO:0071467)4.33515491
26intra-S DNA damage checkpoint (GO:0031573)4.32292167
27RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.20334122
28cilium movement (GO:0003341)4.15513253
29galactose catabolic process (GO:0019388)4.14450288
30response to UV-B (GO:0010224)4.07419688
31chondroitin sulfate catabolic process (GO:0030207)4.05578604
32negative regulation of DNA recombination (GO:0045910)4.04527870
33histone H2A acetylation (GO:0043968)4.04299740
34removal of superoxide radicals (GO:0019430)4.04070518
35cellular response to superoxide (GO:0071451)4.04070518
36cellular response to oxygen radical (GO:0071450)4.04070518
37double-strand break repair via nonhomologous end joining (GO:0006303)3.86735708
38non-recombinational repair (GO:0000726)3.86735708
39regulation of MHC class II biosynthetic process (GO:0045346)3.86490452
40pyrimidine dimer repair (GO:0006290)3.73490764
41anterograde axon cargo transport (GO:0008089)3.64028358
42protein targeting to peroxisome (GO:0006625)3.57566770
43establishment of protein localization to peroxisome (GO:0072663)3.57566770
44protein localization to peroxisome (GO:0072662)3.57566770
45regulation of mitotic spindle checkpoint (GO:1903504)3.56195223
46regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.56195223
47snRNA processing (GO:0016180)3.54782188
48arginine catabolic process (GO:0006527)3.54410552
49response to superoxide (GO:0000303)3.50158752
50somite development (GO:0061053)3.47532513
51ATP synthesis coupled proton transport (GO:0015986)3.43642299
52energy coupled proton transport, down electrochemical gradient (GO:0015985)3.43642299
53response to oxygen radical (GO:0000305)3.40246699
54fatty acid homeostasis (GO:0055089)3.33254323
55mismatch repair (GO:0006298)3.26656111
56negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.25926730
57DNA double-strand break processing (GO:0000729)3.21120662
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20796111
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17353998
60snRNA metabolic process (GO:0016073)3.14480178
61peroxisomal transport (GO:0043574)3.12725762
62cellular response to cholesterol (GO:0071397)3.11967424
63ovulation from ovarian follicle (GO:0001542)3.11185517
64hyaluronan catabolic process (GO:0030214)3.10393820
65thalamus development (GO:0021794)3.09952397
66epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09743281
67anatomical structure regression (GO:0060033)3.08275908
68cellular response to sterol (GO:0036315)3.05588819
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.00362777
70regulation of synaptic vesicle exocytosis (GO:2000300)2.99181536
71positive regulation of vascular permeability (GO:0043117)2.98738491
72axoneme assembly (GO:0035082)2.90729346
73generation of neurons (GO:0048699)2.85836724
74metaphase plate congression (GO:0051310)2.84787302
75C-terminal protein amino acid modification (GO:0018410)2.80567915
76lipid particle organization (GO:0034389)2.77368688
77genitalia morphogenesis (GO:0035112)2.74271658
78hematopoietic stem cell proliferation (GO:0071425)2.71198178
79regulation of bile acid biosynthetic process (GO:0070857)2.67651860
80limb bud formation (GO:0060174)2.66722612
81regulation of cAMP-dependent protein kinase activity (GO:2000479)2.65104917
82adult heart development (GO:0007512)2.64941453
83preassembly of GPI anchor in ER membrane (GO:0016254)2.63681810
84regulation of histone H3-K9 methylation (GO:0051570)2.59527269
85digestive tract morphogenesis (GO:0048546)2.57669589
86macroautophagy (GO:0016236)2.57268014
87intracellular protein transmembrane transport (GO:0065002)2.55844166
88amino acid salvage (GO:0043102)2.54281189
89L-methionine salvage (GO:0071267)2.54281189
90L-methionine biosynthetic process (GO:0071265)2.54281189
91transcription elongation from RNA polymerase III promoter (GO:0006385)2.54026466
92termination of RNA polymerase III transcription (GO:0006386)2.54026466
93negative regulation of JUN kinase activity (GO:0043508)2.52624687
94negative regulation of macroautophagy (GO:0016242)2.52118963
95mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.50850594
96regulation of collateral sprouting (GO:0048670)2.49901742
97rRNA catabolic process (GO:0016075)2.49807275
98positive regulation of neurological system process (GO:0031646)2.47214581
99cullin deneddylation (GO:0010388)2.44781537
100mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.44732366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.85428973
2MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.40259297
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.38428732
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14986613
5IGF1R_20145208_ChIP-Seq_DFB_Human2.73124822
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.72702658
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.58507130
8GBX2_23144817_ChIP-Seq_PC3_Human2.56781209
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43384268
10TAF15_26573619_Chip-Seq_HEK293_Human2.34486293
11E2F7_22180533_ChIP-Seq_HELA_Human2.31674942
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27939947
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.21241925
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.21137040
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.15568156
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08341041
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06633985
18BCAT_22108803_ChIP-Seq_LS180_Human2.04275035
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.03428342
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.02405812
21EWS_26573619_Chip-Seq_HEK293_Human2.02277592
22FUS_26573619_Chip-Seq_HEK293_Human1.99018634
23P300_19829295_ChIP-Seq_ESCs_Human1.90509617
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88460255
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80205021
26AR_21572438_ChIP-Seq_LNCaP_Human1.79055015
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72449066
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68157106
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63798861
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62802637
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62559141
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61089185
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59846444
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59342627
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.57472395
36ELK1_19687146_ChIP-ChIP_HELA_Human1.55195133
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.47550746
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47056802
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45688103
40AR_25329375_ChIP-Seq_VCAP_Human1.41154068
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38972720
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38798284
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.36627059
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36481843
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36245534
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34739273
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33155210
48NCOR_22424771_ChIP-Seq_293T_Human1.32970802
49HOXB7_26014856_ChIP-Seq_BT474_Human1.32813439
50NANOG_19829295_ChIP-Seq_ESCs_Human1.30833242
51SOX2_19829295_ChIP-Seq_ESCs_Human1.30833242
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29970514
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29970514
54SMAD4_21799915_ChIP-Seq_A2780_Human1.29579511
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.25707768
56DCP1A_22483619_ChIP-Seq_HELA_Human1.25157856
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23242143
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.21775808
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21177647
60AHR_22903824_ChIP-Seq_MCF-7_Human1.20231744
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20181895
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19917125
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19041141
64ER_23166858_ChIP-Seq_MCF-7_Human1.18292019
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.16991367
66CDX2_22108803_ChIP-Seq_LS180_Human1.16846010
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15435007
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14920094
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14541600
70TCF4_23295773_ChIP-Seq_U87_Human1.13589502
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10670477
72TCF4_22108803_ChIP-Seq_LS180_Human1.10162188
73TP53_22573176_ChIP-Seq_HFKS_Human1.07773352
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06846405
75STAT3_23295773_ChIP-Seq_U87_Human1.05672677
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03667991
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02999950
78CBP_20019798_ChIP-Seq_JUKART_Human1.02999950
79ISL1_27105846_Chip-Seq_CPCs_Mouse1.01798787
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01716350
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01232673
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01205730
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00317483
84AR_21909140_ChIP-Seq_LNCAP_Human0.97357305
85E2F1_18555785_Chip-Seq_ESCs_Mouse0.97329736
86SMAD3_21741376_ChIP-Seq_EPCs_Human0.96000581
87ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95010769
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94736553
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93655630
90ARNT_22903824_ChIP-Seq_MCF-7_Human0.91756415
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91361268
92RUNX2_22187159_ChIP-Seq_PCA_Human0.90385651
93P300_18555785_Chip-Seq_ESCs_Mouse0.90053603
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88613582
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88354763
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88318648
97SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88161376
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88054720
99FOXP3_21729870_ChIP-Seq_TREG_Human0.87781145
100IRF1_19129219_ChIP-ChIP_H3396_Human0.86381015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.76262598
2MP0003136_yellow_coat_color3.73172724
3MP0008877_abnormal_DNA_methylation3.33832243
4MP0002102_abnormal_ear_morphology3.33817030
5MP0000372_irregular_coat_pigmentation3.16940320
6MP0008058_abnormal_DNA_repair3.14366607
7MP0004147_increased_porphyrin_level2.71425859
8MP0005310_abnormal_salivary_gland2.39027340
9MP0003122_maternal_imprinting2.24787466
10MP0000015_abnormal_ear_pigmentation2.24712065
11MP0010030_abnormal_orbit_morphology2.24614028
12MP0001529_abnormal_vocalization2.19453620
13MP0005174_abnormal_tail_pigmentation2.19365542
14MP0002089_abnormal_postnatal_growth/wei2.13280034
15MP0009697_abnormal_copulation2.02269287
16MP0000462_abnormal_digestive_system2.00134222
17MP0003941_abnormal_skin_development1.95033444
18MP0002254_reproductive_system_inflammat1.87070671
19MP0008872_abnormal_physiological_respon1.77029403
20MP0003121_genomic_imprinting1.75151025
21MP0002090_abnormal_vision1.72682578
22MP0005075_abnormal_melanosome_morpholog1.70928547
23MP0000631_abnormal_neuroendocrine_gland1.66738363
24MP0009745_abnormal_behavioral_response1.62213381
25MP0003937_abnormal_limbs/digits/tail_de1.56036500
26MP0003115_abnormal_respiratory_system1.55916409
27MP0003283_abnormal_digestive_organ1.53575643
28MP0003011_delayed_dark_adaptation1.52230031
29MP0005408_hypopigmentation1.48132857
30MP0004133_heterotaxia1.46434599
31MP0001293_anophthalmia1.45309793
32MP0005171_absent_coat_pigmentation1.39162522
33MP0003111_abnormal_nucleus_morphology1.37606643
34MP0002557_abnormal_social/conspecific_i1.30569370
35MP0002282_abnormal_trachea_morphology1.29862401
36MP0005083_abnormal_biliary_tract1.23379020
37MP0004381_abnormal_hair_follicle1.22366341
38MP0002638_abnormal_pupillary_reflex1.18486755
39MP0003942_abnormal_urinary_system1.18000388
40MP0000566_synostosis1.16990292
41MP0005220_abnormal_exocrine_pancreas1.14626472
42MP0005266_abnormal_metabolism1.14548952
43MP0005253_abnormal_eye_physiology1.12761242
44MP0002933_joint_inflammation1.09843714
45MP0005551_abnormal_eye_electrophysiolog1.08523494
46MP0005391_vision/eye_phenotype1.05784938
47MP0002938_white_spotting1.05148051
48MP0001486_abnormal_startle_reflex1.01769772
49MP0002064_seizures1.01625859
50MP0005409_darkened_coat_color1.01574250
51MP0009672_abnormal_birth_weight1.01097146
52MP0001970_abnormal_pain_threshold1.00951185
53MP0002909_abnormal_adrenal_gland1.00664686
54MP0003119_abnormal_digestive_system1.00408276
55MP0002132_abnormal_respiratory_system0.98440130
56MP0003755_abnormal_palate_morphology0.97384030
57MP0010094_abnormal_chromosome_stability0.96211296
58MP0003077_abnormal_cell_cycle0.96109918
59MP0004264_abnormal_extraembryonic_tissu0.94643932
60MP0001929_abnormal_gametogenesis0.92460735
61MP0002092_abnormal_eye_morphology0.92065550
62MP0002876_abnormal_thyroid_physiology0.91534974
63MP0001286_abnormal_eye_development0.91241158
64MP0002233_abnormal_nose_morphology0.90696846
65MP0004957_abnormal_blastocyst_morpholog0.90506359
66MP0002751_abnormal_autonomic_nervous0.90368128
67MP0009046_muscle_twitch0.89778604
68MP0001299_abnormal_eye_distance/0.88579695
69MP0001986_abnormal_taste_sensitivity0.88261810
70MP0002084_abnormal_developmental_patter0.87914279
71MP0000383_abnormal_hair_follicle0.87469546
72MP0002095_abnormal_skin_pigmentation0.86453805
73MP0002210_abnormal_sex_determination0.84367184
74MP0001984_abnormal_olfaction0.84153593
75MP0003567_abnormal_fetal_cardiomyocyte0.83335612
76MP0000537_abnormal_urethra_morphology0.82934898
77MP0001145_abnormal_male_reproductive0.82309195
78MP0001119_abnormal_female_reproductive0.81568476
79MP0002085_abnormal_embryonic_tissue0.81244956
80MP0002736_abnormal_nociception_after0.81124294
81MP0003878_abnormal_ear_physiology0.80465525
82MP0005377_hearing/vestibular/ear_phenot0.80465525
83MP0003861_abnormal_nervous_system0.80127839
84MP0003943_abnormal_hepatobiliary_system0.80018944
85MP0003718_maternal_effect0.79575317
86MP0000653_abnormal_sex_gland0.79255284
87MP0001697_abnormal_embryo_size0.79005039
88MP0006036_abnormal_mitochondrial_physio0.77035856
89MP0010386_abnormal_urinary_bladder0.74547034
90MP0003698_abnormal_male_reproductive0.73492485
91MP0004924_abnormal_behavior0.73212420
92MP0005386_behavior/neurological_phenoty0.73212420
93MP0001324_abnormal_eye_pigmentation0.71898220
94MP0005332_abnormal_amino_acid0.71302066
95MP0005084_abnormal_gallbladder_morpholo0.69771668
96MP0002116_abnormal_craniofacial_bone0.67963447
97MP0002837_dystrophic_cardiac_calcinosis0.67914654
98MP0003186_abnormal_redox_activity0.67396643
99MP0002697_abnormal_eye_size0.67244436
100MP0002067_abnormal_sensory_capabilities0.67013812

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)8.29680072
2Submucous cleft hard palate (HP:0000176)6.37288803
3Ependymoma (HP:0002888)5.29676686
4Mucopolysacchariduria (HP:0008155)4.46065184
5Urinary glycosaminoglycan excretion (HP:0003541)4.46065184
6Abnormality of polysaccharide metabolism (HP:0011012)4.18934546
7Abnormality of glycosaminoglycan metabolism (HP:0004371)4.18934546
8Abnormality of mucopolysaccharide metabolism (HP:0011020)4.18934546
9Neoplasm of the adrenal cortex (HP:0100641)3.67792229
10Agnosia (HP:0010524)3.65296118
11Astrocytoma (HP:0009592)3.61419913
12Abnormality of the astrocytes (HP:0100707)3.61419913
13Neoplasm of the oral cavity (HP:0100649)3.48346998
14Bifid tongue (HP:0010297)3.38197987
15Poikiloderma (HP:0001029)3.35112107
16Pancreatic islet-cell hyperplasia (HP:0004510)3.34276093
17Vacuolated lymphocytes (HP:0001922)3.32400719
18Abnormal gallbladder physiology (HP:0012438)3.27180554
19Cholecystitis (HP:0001082)3.27180554
20Cervical subluxation (HP:0003308)3.21307641
21Brushfield spots (HP:0001088)3.20445485
22Disproportionate short-trunk short stature (HP:0003521)3.04734706
23Beaking of vertebral bodies (HP:0004568)3.03529064
24Abnormality of the pancreatic islet cells (HP:0006476)2.95963650
25Abnormality of endocrine pancreas physiology (HP:0012093)2.95963650
26Prostate neoplasm (HP:0100787)2.89859182
27Glioma (HP:0009733)2.84504848
28Pancreatic cysts (HP:0001737)2.83249501
29Breast carcinoma (HP:0003002)2.79061388
30Focal motor seizures (HP:0011153)2.77126143
31Medulloblastoma (HP:0002885)2.62563945
32Abnormality of the labia minora (HP:0012880)2.61176507
33Neoplasm of the liver (HP:0002896)2.53651740
34Hypoplasia of the odontoid process (HP:0003311)2.53165446
35Abnormality of methionine metabolism (HP:0010901)2.51403195
36Rhabdomyosarcoma (HP:0002859)2.50482314
37Cerebellar dysplasia (HP:0007033)2.47723570
38Intestinal atresia (HP:0011100)2.46654755
39Neoplasm of the adrenal gland (HP:0100631)2.44304445
40High anterior hairline (HP:0009890)2.43259426
41Molar tooth sign on MRI (HP:0002419)2.41118289
42Abnormality of midbrain morphology (HP:0002418)2.41118289
43Late onset (HP:0003584)2.39021835
44True hermaphroditism (HP:0010459)2.34819546
45Amaurosis fugax (HP:0100576)2.22321064
46Short tibia (HP:0005736)2.19851810
47Pancreatic fibrosis (HP:0100732)2.19416722
48Ulnar deviation of the wrist (HP:0003049)2.16251637
49Benign neoplasm of the central nervous system (HP:0100835)2.14507827
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.13803040
51Type II lissencephaly (HP:0007260)2.12792228
52Bilateral microphthalmos (HP:0007633)2.10615185
53Cellular immunodeficiency (HP:0005374)2.08883977
54Neoplasm of striated muscle (HP:0009728)2.04911424
55Gaze-evoked nystagmus (HP:0000640)2.03960122
56Methylmalonic acidemia (HP:0002912)2.02378413
57Angiofibromas (HP:0010615)2.01854020
58Adenoma sebaceum (HP:0009720)2.01854020
59Sensory axonal neuropathy (HP:0003390)1.96775173
60Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94768931
61Aplasia/Hypoplasia of the fovea (HP:0008060)1.93405507
62Hypoplasia of the fovea (HP:0007750)1.93405507
63Bifid uvula (HP:0000193)1.93225449
64Hyperglycinemia (HP:0002154)1.93175511
65Unsteady gait (HP:0002317)1.92796491
66Abnormality of the salivary glands (HP:0010286)1.92735549
67Neoplasm of the colon (HP:0100273)1.92172618
68Large for gestational age (HP:0001520)1.91404821
69Female pseudohermaphroditism (HP:0010458)1.91269586
70Hypoplastic nipples (HP:0002557)1.89384202
71Congenital stationary night blindness (HP:0007642)1.89236445
72Generalized myoclonic seizures (HP:0002123)1.89236404
73Bicornuate uterus (HP:0000813)1.84625271
74Abnormality of the odontoid process (HP:0003310)1.84605304
75Thickened nuchal skin fold (HP:0000474)1.83832178
76Cystic liver disease (HP:0006706)1.80214133
77Double outlet right ventricle (HP:0001719)1.78365840
78Congenital malformation of the right heart (HP:0011723)1.78365840
79Broad palm (HP:0001169)1.76662538
80Anophthalmia (HP:0000528)1.75322463
81Attenuation of retinal blood vessels (HP:0007843)1.73505725
82Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.72916759
83Vertebral hypoplasia (HP:0008417)1.72916759
84Albinism (HP:0001022)1.71394881
85Nephroblastoma (Wilms tumor) (HP:0002667)1.70691624
86Abnormality of the fovea (HP:0000493)1.70192049
87Epiphyseal stippling (HP:0010655)1.69882486
88Abnormality of the acetabulum (HP:0003170)1.69391982
89Enlarged kidneys (HP:0000105)1.68729123
90Optic disc pallor (HP:0000543)1.68566483
91Partial agenesis of the corpus callosum (HP:0001338)1.66691260
92Hepatocellular carcinoma (HP:0001402)1.66264543
93Progressive neurologic deterioration (HP:0002344)1.65752388
94Subacute progressive viral hepatitis (HP:0006572)1.65167882
95Abnormal lung lobation (HP:0002101)1.64718014
96Triphalangeal thumb (HP:0001199)1.64440172
97Duplicated collecting system (HP:0000081)1.62407096
98Broad alveolar ridges (HP:0000187)1.59294030
99Broad-based gait (HP:0002136)1.59166921
100Embryonal renal neoplasm (HP:0011794)1.57988660

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.02324594
2ADRBK25.33213738
3TAF15.21706230
4SMG14.35798633
5NUAK14.26906384
6MAP4K23.05762215
7TRIM282.61185874
8MAPKAPK52.28930432
9DYRK32.27551190
10PBK2.15641760
11TNIK2.15201279
12VRK11.97958412
13CASK1.86165948
14CSNK1G11.83158930
15CSNK1G31.66358591
16AKT31.64244900
17CSNK1A1L1.62539696
18CDC71.56182111
19FRK1.48696671
20BMPR1B1.34876991
21NME11.32416556
22PIK3CG1.32388699
23ACVR1B1.26601557
24PLK31.24414942
25CSNK1G21.22152122
26CLK11.21666311
27CDK91.21410497
28WEE11.19954549
29ERBB31.17093795
30GRK51.15879718
31TGFBR11.12022145
32PRKCI1.07076520
33MAP3K21.00961279
34DAPK10.98406789
35MELK0.97820897
36SIK30.90787762
37MAP3K120.87109698
38DYRK20.87072289
39NTRK30.80500337
40DYRK1A0.80347241
41TSSK60.75875668
42WNK30.75867705
43MKNK20.74854771
44LATS10.67688410
45EPHB20.67587358
46EIF2AK20.66190650
47PRKAA20.65929191
48PNCK0.65763883
49TNK20.64286467
50FGFR20.64217806
51SIK20.61831041
52STK390.59141872
53TTK0.58805780
54PAK30.56937836
55PASK0.55304711
56CHEK20.55203662
57PIK3CA0.54805071
58STK40.54155628
59OXSR10.53717023
60PLK40.51849777
61BRSK20.50653708
62STK110.49856825
63BRD40.49850712
64DAPK30.48763228
65STK30.47545628
66BCR0.47254870
67PDK20.46015890
68PLK20.45872463
69CAMK1G0.45595035
70MAPKAPK30.45354683
71EEF2K0.44712979
72KSR10.44451690
73FER0.43732729
74PRKAA10.43593647
75NLK0.43364039
76TRPM70.42189356
77BRSK10.41651311
78HIPK20.34901198
79INSRR0.34774811
80MKNK10.34133129
81TGFBR20.30726929
82CDK70.30120954
83YES10.30112147
84FGFR10.29951971
85EPHA40.27935857
86CAMK1D0.27723602
87PRKCH0.27433979
88NEK20.27219140
89ATR0.26837126
90PINK10.26718317
91MAP3K40.25803151
92NTRK20.24663148
93PLK10.24511881
94PRKCG0.23179566
95RPS6KB20.22969030
96CHEK10.22854832
97GSK3A0.20396931
98GRK10.18615616
99ZAK0.18344080
100ERBB20.16267899

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.82913050
2Non-homologous end-joining_Homo sapiens_hsa034504.57197211
3Basal cell carcinoma_Homo sapiens_hsa052173.40516195
4Hedgehog signaling pathway_Homo sapiens_hsa043403.08890342
5Proteasome_Homo sapiens_hsa030502.74995274
6Fanconi anemia pathway_Homo sapiens_hsa034602.61023075
7Protein export_Homo sapiens_hsa030602.55025880
8Mismatch repair_Homo sapiens_hsa034302.50263710
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.49866012
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.37140850
11Homologous recombination_Homo sapiens_hsa034402.34271068
12Sulfur metabolism_Homo sapiens_hsa009202.07968954
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00555960
14RNA degradation_Homo sapiens_hsa030181.96781701
15Steroid biosynthesis_Homo sapiens_hsa001001.96126452
16RNA polymerase_Homo sapiens_hsa030201.90161414
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71587910
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.70729348
19Propanoate metabolism_Homo sapiens_hsa006401.57246347
20Selenocompound metabolism_Homo sapiens_hsa004501.55139551
21Oxidative phosphorylation_Homo sapiens_hsa001901.46943320
22Base excision repair_Homo sapiens_hsa034101.46004113
23Peroxisome_Homo sapiens_hsa041461.40829418
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36538872
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31323359
26Lysine degradation_Homo sapiens_hsa003101.26920031
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.26902584
28Regulation of autophagy_Homo sapiens_hsa041401.26557467
29Glutathione metabolism_Homo sapiens_hsa004801.23287236
30Phototransduction_Homo sapiens_hsa047441.22556145
31Parkinsons disease_Homo sapiens_hsa050121.21881571
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15606115
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13330108
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13205230
35Huntingtons disease_Homo sapiens_hsa050161.12918466
36One carbon pool by folate_Homo sapiens_hsa006701.10963793
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10857176
38RNA transport_Homo sapiens_hsa030131.10360044
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07378518
40Circadian rhythm_Homo sapiens_hsa047101.05491498
41Other glycan degradation_Homo sapiens_hsa005110.93882115
42Fructose and mannose metabolism_Homo sapiens_hsa000510.92472310
43Thyroid cancer_Homo sapiens_hsa052160.89799299
44Caffeine metabolism_Homo sapiens_hsa002320.83332509
45Colorectal cancer_Homo sapiens_hsa052100.82753783
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81654434
47Olfactory transduction_Homo sapiens_hsa047400.80111101
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78933489
49Linoleic acid metabolism_Homo sapiens_hsa005910.78540817
50Pyruvate metabolism_Homo sapiens_hsa006200.76377910
51Purine metabolism_Homo sapiens_hsa002300.72954337
52Butanoate metabolism_Homo sapiens_hsa006500.72339095
53Alzheimers disease_Homo sapiens_hsa050100.72208131
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67928282
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66728435
56Inositol phosphate metabolism_Homo sapiens_hsa005620.66395097
57Ether lipid metabolism_Homo sapiens_hsa005650.66175928
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.63549045
59Synaptic vesicle cycle_Homo sapiens_hsa047210.63014837
60Fatty acid elongation_Homo sapiens_hsa000620.62887274
61Galactose metabolism_Homo sapiens_hsa000520.58477076
62Tryptophan metabolism_Homo sapiens_hsa003800.56263396
63Metabolic pathways_Homo sapiens_hsa011000.55618479
64Mineral absorption_Homo sapiens_hsa049780.55163707
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54653782
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51848075
67Nitrogen metabolism_Homo sapiens_hsa009100.50802751
68Insulin secretion_Homo sapiens_hsa049110.50356554
69Glucagon signaling pathway_Homo sapiens_hsa049220.49991707
70Cell cycle_Homo sapiens_hsa041100.49805345
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49528122
72Carbon metabolism_Homo sapiens_hsa012000.48311305
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44127873
74Retinol metabolism_Homo sapiens_hsa008300.43051769
75p53 signaling pathway_Homo sapiens_hsa041150.40471087
76Lysosome_Homo sapiens_hsa041420.40235372
77Adherens junction_Homo sapiens_hsa045200.38603153
78beta-Alanine metabolism_Homo sapiens_hsa004100.37115208
79Pyrimidine metabolism_Homo sapiens_hsa002400.36152311
80Nucleotide excision repair_Homo sapiens_hsa034200.35595010
81Wnt signaling pathway_Homo sapiens_hsa043100.35099795
82Pancreatic secretion_Homo sapiens_hsa049720.34202876
83N-Glycan biosynthesis_Homo sapiens_hsa005100.32898862
84Endometrial cancer_Homo sapiens_hsa052130.31911748
85Chemical carcinogenesis_Homo sapiens_hsa052040.30715543
86GABAergic synapse_Homo sapiens_hsa047270.30175316
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29819126
88Ovarian steroidogenesis_Homo sapiens_hsa049130.28916498
89Hippo signaling pathway_Homo sapiens_hsa043900.28683286
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28466295
91Ribosome_Homo sapiens_hsa030100.28447393
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.28386172
93Pathways in cancer_Homo sapiens_hsa052000.27351641
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24719298
95Folate biosynthesis_Homo sapiens_hsa007900.24460223
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24036232
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23321946
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22645412
99Arachidonic acid metabolism_Homo sapiens_hsa005900.22633438
100Collecting duct acid secretion_Homo sapiens_hsa049660.21541469

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