ZMYND8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.64563675
2establishment of integrated proviral latency (GO:0075713)5.42166130
3deoxyribonucleoside diphosphate metabolic process (GO:0009186)5.35507106
4deoxyribonucleotide biosynthetic process (GO:0009263)5.33965348
5negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)5.03486651
6ribosomal small subunit biogenesis (GO:0042274)4.95651297
7mitochondrial DNA replication (GO:0006264)4.88819399
8spliceosomal complex assembly (GO:0000245)4.69424174
9deoxyribonucleoside triphosphate metabolic process (GO:0009200)4.65705129
10transcription elongation from RNA polymerase III promoter (GO:0006385)4.57292888
11termination of RNA polymerase III transcription (GO:0006386)4.57292888
12spliceosomal snRNP assembly (GO:0000387)4.56893496
13regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)4.54119574
14ribosomal large subunit biogenesis (GO:0042273)4.50880111
15telomere maintenance via semi-conservative replication (GO:0032201)4.32470512
16maturation of SSU-rRNA (GO:0030490)4.26933544
17ribonucleoprotein complex biogenesis (GO:0022613)4.19766983
18exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.19412846
19proteasome assembly (GO:0043248)4.17162003
20nucleobase-containing small molecule interconversion (GO:0015949)4.12875696
21rRNA modification (GO:0000154)4.10465345
22ribosome assembly (GO:0042255)4.09810408
23viral transcription (GO:0019083)4.09588740
24DNA strand elongation involved in DNA replication (GO:0006271)4.05473686
25deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.05228456
26nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.01292615
27DNA damage response, detection of DNA damage (GO:0042769)4.01061001
28establishment of viral latency (GO:0019043)3.99898865
29translational termination (GO:0006415)3.97388199
30DNA-dependent DNA replication (GO:0006261)3.96884854
31DNA replication initiation (GO:0006270)3.93158853
32regulation of mitochondrial translation (GO:0070129)3.92919258
337-methylguanosine mRNA capping (GO:0006370)3.91394068
34DNA strand elongation (GO:0022616)3.88108443
35ribosome biogenesis (GO:0042254)3.87717660
367-methylguanosine RNA capping (GO:0009452)3.81556450
37RNA capping (GO:0036260)3.81556450
38telomere maintenance via recombination (GO:0000722)3.78799747
39nuclear pore complex assembly (GO:0051292)3.78065868
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.75222913
41ribosomal small subunit assembly (GO:0000028)3.74929759
42protein complex localization (GO:0031503)3.73635462
43rRNA processing (GO:0006364)3.72275883
44translational elongation (GO:0006414)3.66948495
45transcription-coupled nucleotide-excision repair (GO:0006283)3.66730853
46regulation of centriole replication (GO:0046599)3.66611325
47mitochondrial DNA metabolic process (GO:0032042)3.65596353
48DNA topological change (GO:0006265)3.64349768
49kinetochore assembly (GO:0051382)3.58958912
50rRNA metabolic process (GO:0016072)3.58861796
51DNA replication checkpoint (GO:0000076)3.58440054
52translational initiation (GO:0006413)3.55258439
53positive regulation of prostaglandin secretion (GO:0032308)3.54050600
54histone H4-K12 acetylation (GO:0043983)3.53890694
55mitotic sister chromatid cohesion (GO:0007064)3.49233645
56pseudouridine synthesis (GO:0001522)3.48549908
57histone H2A acetylation (GO:0043968)3.47495913
58maturation of 5.8S rRNA (GO:0000460)3.46257238
59RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.45718042
60tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.45718042
61regulation of histone H3-K9 methylation (GO:0051570)3.45565041
62nucleobase biosynthetic process (GO:0046112)3.43391718
63translation (GO:0006412)3.41040143
64SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39403194
65telomere maintenance via telomere lengthening (GO:0010833)3.39258747
66viral mRNA export from host cell nucleus (GO:0046784)3.39023448
67transcription from RNA polymerase I promoter (GO:0006360)3.37492058
68mitotic recombination (GO:0006312)3.36757318
69protein localization to kinetochore (GO:0034501)3.35526733
70formation of translation preinitiation complex (GO:0001731)3.35099921
71cotranslational protein targeting to membrane (GO:0006613)3.33131455
72protein targeting to ER (GO:0045047)3.31634713
73RNA destabilization (GO:0050779)3.31494542
74nuclear pore organization (GO:0006999)3.30973480
75CENP-A containing nucleosome assembly (GO:0034080)3.30723239
76cellular component biogenesis (GO:0044085)3.30540288
77peptidyl-arginine omega-N-methylation (GO:0035247)3.28814942
78chromatin remodeling at centromere (GO:0031055)3.25110520
79histone arginine methylation (GO:0034969)3.24729092
80regulation of posttranscriptional gene silencing (GO:0060147)3.24417253
81regulation of gene silencing by miRNA (GO:0060964)3.24417253
82regulation of gene silencing by RNA (GO:0060966)3.24417253
83pre-miRNA processing (GO:0031054)3.24003751
84nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.23923786
85UTP biosynthetic process (GO:0006228)3.21877298
86cellular protein complex disassembly (GO:0043624)3.21396620
87DNA replication-independent nucleosome organization (GO:0034724)3.20708935
88DNA replication-independent nucleosome assembly (GO:0006336)3.20708935
89DNA unwinding involved in DNA replication (GO:0006268)3.20351390
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18310887
91negative regulation of histone methylation (GO:0031061)3.17862870
92histone exchange (GO:0043486)3.17242520
93mitotic metaphase plate congression (GO:0007080)3.16905633
94kinetochore organization (GO:0051383)3.15313052
95negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.14661515
96establishment of protein localization to endoplasmic reticulum (GO:0072599)3.14383735
97RNA splicing, via transesterification reactions (GO:0000375)3.13211577
98viral life cycle (GO:0019058)3.13050606
99mitotic sister chromatid segregation (GO:0000070)3.12974883
100GTP biosynthetic process (GO:0006183)3.12617892
101mRNA splicing, via spliceosome (GO:0000398)3.12264907
102RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.12264907
103DNA-templated transcription, termination (GO:0006353)3.11962218
104sister chromatid segregation (GO:0000819)3.11860957
105termination of RNA polymerase I transcription (GO:0006363)3.10104163
106protein-cofactor linkage (GO:0018065)3.09621263
107anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09167491
108positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08968268
109regulation of double-strand break repair via homologous recombination (GO:0010569)3.07916352
110IMP biosynthetic process (GO:0006188)3.07800061
111transcription elongation from RNA polymerase I promoter (GO:0006362)3.07338638
112protein localization to endoplasmic reticulum (GO:0070972)3.06896049
113regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06252399
114negative regulation of signal transduction by p53 class mediator (GO:1901797)3.05624449
115regulation of histone H3-K4 methylation (GO:0051569)3.00488992
116DNA strand renaturation (GO:0000733)2.98383068
117L-serine metabolic process (GO:0006563)2.97978454
118mitotic chromosome condensation (GO:0007076)2.97854925
119replication fork processing (GO:0031297)2.93403233
120protein localization to chromosome, centromeric region (GO:0071459)2.92912915
121mitotic nuclear envelope disassembly (GO:0007077)2.87862650
122negative regulation of DNA-dependent DNA replication (GO:2000104)2.87572060
123ATP-dependent chromatin remodeling (GO:0043044)2.86630548
124negative regulation of DNA repair (GO:0045738)2.84279162
125regulation of centrosome cycle (GO:0046605)2.81509149
126heterochromatin organization (GO:0070828)2.80514080
127somatic hypermutation of immunoglobulin genes (GO:0016446)2.77946640
128somatic diversification of immune receptors via somatic mutation (GO:0002566)2.77946640
129negative regulation of translation, ncRNA-mediated (GO:0040033)2.72897506
130regulation of translation, ncRNA-mediated (GO:0045974)2.72897506
131negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.72897506
132regulation of RNA export from nucleus (GO:0046831)2.72452062
133telomere maintenance via telomerase (GO:0007004)2.72340621
134negative regulation of chromosome segregation (GO:0051985)2.72045306
135negative regulation of mitotic sister chromatid separation (GO:2000816)2.70851710
136negative regulation of sister chromatid segregation (GO:0033046)2.70851710
137negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.70851710
138negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.70851710
139negative regulation of mitotic sister chromatid segregation (GO:0033048)2.70851710
140intra-S DNA damage checkpoint (GO:0031573)2.68145871
141mitotic spindle checkpoint (GO:0071174)2.67502208
142spindle checkpoint (GO:0031577)2.67082957
143regulation of translational fidelity (GO:0006450)2.64369962
144folic acid-containing compound biosynthetic process (GO:0009396)2.64206895
145metaphase plate congression (GO:0051310)2.63189463
146purine nucleobase biosynthetic process (GO:0009113)2.62817211
147DNA replication-dependent nucleosome organization (GO:0034723)2.62772429
148DNA replication-dependent nucleosome assembly (GO:0006335)2.62772429
149synapsis (GO:0007129)2.62607018
150pore complex assembly (GO:0046931)2.62522596
151DNA ligation (GO:0006266)2.62376881
152DNA geometric change (GO:0032392)2.61784939
153maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61271583
154DNA duplex unwinding (GO:0032508)2.61137959
155positive regulation of histone H3-K4 methylation (GO:0051571)2.61027297
156membrane disassembly (GO:0030397)2.60169126
157nuclear envelope disassembly (GO:0051081)2.60169126
158nucleosome disassembly (GO:0006337)2.59931715
159protein-DNA complex disassembly (GO:0032986)2.59931715
160regulation of centrosome duplication (GO:0010824)2.59522215
161resolution of meiotic recombination intermediates (GO:0000712)2.58041134
162DNA conformation change (GO:0071103)2.54253293
163chromosome condensation (GO:0030261)2.54104586
164chromatin assembly or disassembly (GO:0006333)2.53903910
165regulation of histone methylation (GO:0031060)2.53178383
166centriole replication (GO:0007099)2.52548182
167regulation of chromosome segregation (GO:0051983)2.52080475
168regulation of DNA endoreduplication (GO:0032875)2.51946320
169biotin metabolic process (GO:0006768)2.51388869
170IMP metabolic process (GO:0046040)2.51064012
171mitotic G2/M transition checkpoint (GO:0044818)2.50164284
172regulation of mitotic sister chromatid separation (GO:0010965)2.49742725
173regulation of mitotic sister chromatid segregation (GO:0033047)2.49742725
174regulation of sister chromatid segregation (GO:0033045)2.49742725
175regulation of mitotic metaphase/anaphase transition (GO:0030071)2.48515537
176regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.48515537
177mitotic spindle assembly checkpoint (GO:0007094)2.47126334
178regulation of stem cell maintenance (GO:2000036)2.46826080
179DNA double-strand break processing (GO:0000729)2.46585729
180homocysteine metabolic process (GO:0050667)2.43984888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.20609115
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.64937325
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.14844061
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.81815754
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71309252
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.68021137
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.64828789
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.48200161
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.35955360
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30272579
11MYC_19030024_ChIP-ChIP_MESCs_Mouse3.17018560
12* FOXM1_23109430_ChIP-Seq_U2OS_Human3.14765922
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.07664353
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.98934371
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.88637706
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.82942540
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71665067
18* XRN2_22483619_ChIP-Seq_HELA_Human2.70334143
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59070372
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47766289
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.47426026
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.46643758
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42581437
24* VDR_23849224_ChIP-Seq_CD4+_Human2.41902241
25* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36676834
26ESR1_15608294_ChIP-ChIP_MCF-7_Human2.27723778
27NANOG_18555785_ChIP-Seq_MESCs_Mouse2.26674541
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13264156
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09212461
30TTF2_22483619_ChIP-Seq_HELA_Human2.04390958
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00721524
32FOXP3_21729870_ChIP-Seq_TREG_Human1.96972601
33CIITA_25753668_ChIP-Seq_RAJI_Human1.95207491
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94735583
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93951144
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93309766
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.90530969
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90149692
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90104673
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88819655
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85332855
42GABP_19822575_ChIP-Seq_HepG2_Human1.81925197
43DCP1A_22483619_ChIP-Seq_HELA_Human1.78652564
44PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.76379269
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74531546
46ELK1_19687146_ChIP-ChIP_HELA_Human1.74171082
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.73110345
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70804881
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69168084
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65310985
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60400628
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56591982
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.56544392
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.56544392
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.56544392
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.56109929
57KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.55092311
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.49607857
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.48055983
60KDM5A_27292631_Chip-Seq_BREAST_Human1.47435829
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.46593877
62SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.43711436
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.42771722
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40113998
65ZNF274_21170338_ChIP-Seq_K562_Hela1.38949443
66* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38190025
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35665641
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34378436
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31758595
70* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29735825
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29653280
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27805561
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21976419
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21022301
75TCF3_18692474_ChIP-Seq_MEFs_Mouse1.20720215
76* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20671531
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18890285
78* ELK1_22589737_ChIP-Seq_MCF10A_Human1.17643916
79EWS_26573619_Chip-Seq_HEK293_Human1.17116663
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16768110
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15140392
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13965018
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13190695
84* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13077209
85AR_21909140_ChIP-Seq_LNCAP_Human1.12623620
86VDR_22108803_ChIP-Seq_LS180_Human1.12517516
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11979927
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09960407
89MYC_18940864_ChIP-ChIP_HL60_Human1.09168527
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.08133564
91RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08056974
92OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08014080
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05668985
94HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03732488
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03699230
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03570593
97* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00360106
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99703183
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98349402
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98313388
101ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97888100
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97852464
103KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97681316
104SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97441784
105FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97274352
106ZNF263_19887448_ChIP-Seq_K562_Human0.96547512
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95266812
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94268049
109NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93916622
110FOXP1_21924763_ChIP-Seq_HESCs_Human0.93824236
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92627160
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92483774
113CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90182055
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88956808
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88633859
116AR_21572438_ChIP-Seq_LNCaP_Human0.85681299
117SOX17_20123909_ChIP-Seq_XEN_Mouse0.85014144
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84692502
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.83389091
120POU5F1_16518401_ChIP-PET_MESCs_Mouse0.83141153
121GATA1_26923725_Chip-Seq_HPCs_Mouse0.81713872
122* FUS_26573619_Chip-Seq_HEK293_Human0.80882690
123* CHD1_26751641_Chip-Seq_LNCaP_Human0.80461842
124CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.76308029
125IRF1_19129219_ChIP-ChIP_H3396_Human0.74360084
126* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.74225141
127* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.74118872
128PKCTHETA_26484144_Chip-Seq_BREAST_Human0.73064190
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.71185698

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.98792967
2MP0008877_abnormal_DNA_methylation4.64535595
3MP0003111_abnormal_nucleus_morphology4.15416680
4MP0004957_abnormal_blastocyst_morpholog4.02064136
5MP0003077_abnormal_cell_cycle3.65006062
6MP0008058_abnormal_DNA_repair3.46528082
7MP0010094_abnormal_chromosome_stability3.42693756
8MP0008057_abnormal_DNA_replication3.29532059
9MP0008932_abnormal_embryonic_tissue3.11453321
10MP0008007_abnormal_cellular_replicative2.72038154
11MP0004133_heterotaxia2.66800332
12MP0003123_paternal_imprinting2.55172839
13MP0010030_abnormal_orbit_morphology2.48255003
14MP0003890_abnormal_embryonic-extraembry2.38662762
15MP0003122_maternal_imprinting2.18811202
16MP0002938_white_spotting2.17462131
17MP0006292_abnormal_olfactory_placode2.14249939
18MP0002160_abnormal_reproductive_system2.12936170
19MP0003718_maternal_effect2.08147490
20MP0001730_embryonic_growth_arrest2.06826492
21MP0008789_abnormal_olfactory_epithelium2.03999504
22MP0008995_early_reproductive_senescence1.97886136
23MP0005394_taste/olfaction_phenotype1.96988820
24MP0005499_abnormal_olfactory_system1.96988820
25MP0000350_abnormal_cell_proliferation1.91090325
26MP0003786_premature_aging1.88519265
27MP0002653_abnormal_ependyma_morphology1.86481285
28MP0005389_reproductive_system_phenotype1.79934934
29MP0003787_abnormal_imprinting1.75814860
30MP0003119_abnormal_digestive_system1.72467219
31MP0003121_genomic_imprinting1.63922941
32MP0002751_abnormal_autonomic_nervous1.61827443
33MP0009672_abnormal_birth_weight1.58951141
34MP0005408_hypopigmentation1.58297920
35MP0001697_abnormal_embryo_size1.56869303
36MP0005380_embryogenesis_phenotype1.54302007
37MP0001672_abnormal_embryogenesis/_devel1.54302007
38MP0001853_heart_inflammation1.52616787
39MP0004147_increased_porphyrin_level1.51762671
40MP0010352_gastrointestinal_tract_polyps1.51509242
41MP0000313_abnormal_cell_death1.48402543
42MP0002085_abnormal_embryonic_tissue1.46087001
43MP0003315_abnormal_perineum_morphology1.44575389
44MP0009697_abnormal_copulation1.41630408
45MP0002277_abnormal_respiratory_mucosa1.39512367
46MP0003942_abnormal_urinary_system1.38155100
47MP0001293_anophthalmia1.36806521
48MP0002080_prenatal_lethality1.36351218
49MP0000613_abnormal_salivary_gland1.33298962
50MP0003567_abnormal_fetal_cardiomyocyte1.32788069
51MP0005646_abnormal_pituitary_gland1.30170393
52MP0003984_embryonic_growth_retardation1.28143705
53MP0002088_abnormal_embryonic_growth/wei1.27115027
54MP0006035_abnormal_mitochondrial_morpho1.26634295
55MP0002210_abnormal_sex_determination1.18050931
56MP0004264_abnormal_extraembryonic_tissu1.17785545
57MP0001919_abnormal_reproductive_system1.17084073
58MP0002697_abnormal_eye_size1.14006310
59MP0009379_abnormal_foot_pigmentation1.12134128
60MP0001145_abnormal_male_reproductive1.06660719
61MP0006072_abnormal_retinal_apoptosis1.04949616
62MP0000631_abnormal_neuroendocrine_gland1.03595289
63MP0005670_abnormal_white_adipose1.02399496
64MP0009703_decreased_birth_body1.00818612
65MP0002084_abnormal_developmental_patter1.00171504
66MP0003938_abnormal_ear_development0.99011970
67MP0003941_abnormal_skin_development0.97884331
68MP0001286_abnormal_eye_development0.97625467
69MP0003861_abnormal_nervous_system0.97028456
70MP0002396_abnormal_hematopoietic_system0.94290978
71MP0000703_abnormal_thymus_morphology0.94011799
72MP0004197_abnormal_fetal_growth/weight/0.92640856
73MP0002111_abnormal_tail_morphology0.91880082
74MP0000428_abnormal_craniofacial_morphol0.90790774
75MP0005075_abnormal_melanosome_morpholog0.88253472
76MP0005384_cellular_phenotype0.88203352
77MP0000653_abnormal_sex_gland0.88175359
78MP0002086_abnormal_extraembryonic_tissu0.87241619
79MP0001188_hyperpigmentation0.86422141
80MP0000647_abnormal_sebaceous_gland0.84717009
81MP0004142_abnormal_muscle_tone0.83996973
82MP0010307_abnormal_tumor_latency0.83170848
83MP0002089_abnormal_postnatal_growth/wei0.83058438
84MP0003935_abnormal_craniofacial_develop0.82417851
85MP0000383_abnormal_hair_follicle0.82408965
86MP0000372_irregular_coat_pigmentation0.82267891
87MP0003943_abnormal_hepatobiliary_system0.82096927
88MP0002736_abnormal_nociception_after0.81560775
89MP0005395_other_phenotype0.81530102
90MP0000432_abnormal_head_morphology0.80286946
91MP0001929_abnormal_gametogenesis0.79776531
92MP0003115_abnormal_respiratory_system0.79517192
93MP0001299_abnormal_eye_distance/0.77704451
94MP0002009_preneoplasia0.77033767
95MP0003937_abnormal_limbs/digits/tail_de0.76758506
96MP0000678_abnormal_parathyroid_gland0.76596051
97MP0000566_synostosis0.76566271
98MP0001324_abnormal_eye_pigmentation0.76006567
99MP0002092_abnormal_eye_morphology0.74701689
100MP0000358_abnormal_cell_content/0.74422240
101MP0001661_extended_life_span0.74024053
102MP0002161_abnormal_fertility/fecundity0.73958877
103MP0004270_analgesia0.73266590
104MP0002019_abnormal_tumor_incidence0.72964988
105MP0003755_abnormal_palate_morphology0.72935364
106MP0005621_abnormal_cell_physiology0.72803563
107MP0001984_abnormal_olfaction0.71361275
108MP0003699_abnormal_female_reproductive0.71042038
109MP0000049_abnormal_middle_ear0.69921337
110MP0003936_abnormal_reproductive_system0.69284867
111MP0003385_abnormal_body_wall0.68294456
112MP0001119_abnormal_female_reproductive0.66167281
113MP0003638_abnormal_response/metabolism_0.65950252
114MP0002269_muscular_atrophy0.64887569
115MP0003698_abnormal_male_reproductive0.63965635
116MP0002254_reproductive_system_inflammat0.62415826
117MP0002752_abnormal_somatic_nervous0.61461085
118MP0005076_abnormal_cell_differentiation0.59939163
119MP0001485_abnormal_pinna_reflex0.59805955
120MP0000750_abnormal_muscle_regeneration0.59011733
121MP0000858_altered_metastatic_potential0.58649728
122MP0002114_abnormal_axial_skeleton0.56500084
123MP0001529_abnormal_vocalization0.55345803
124MP0001186_pigmentation_phenotype0.54524442
125MP0008770_decreased_survivor_rate0.54468379
126MP0003136_yellow_coat_color0.54217854
127MP0002249_abnormal_larynx_morphology0.53960538
128MP0002233_abnormal_nose_morphology0.53487036
129MP0005248_abnormal_Harderian_gland0.53008102
130MP0000537_abnormal_urethra_morphology0.51247401
131MP0003878_abnormal_ear_physiology0.50749671
132MP0005377_hearing/vestibular/ear_phenot0.50749671
133MP0002184_abnormal_innervation0.50613765
134MP0000490_abnormal_crypts_of0.50510872
135MP0002116_abnormal_craniofacial_bone0.50386910

Predicted human phenotypes

RankGene SetZ-score
1Progressive external ophthalmoplegia (HP:0000590)8.31123003
2Muscle abnormality related to mitochondrial dysfunction (HP:0003800)5.19858914
3Breast hypoplasia (HP:0003187)4.46257858
4Birth length less than 3rd percentile (HP:0003561)4.15908580
5Proximal tubulopathy (HP:0000114)4.09300299
6External ophthalmoplegia (HP:0000544)3.92717330
7Carpal bone hypoplasia (HP:0001498)3.89677959
8Reticulocytopenia (HP:0001896)3.65039979
9Colon cancer (HP:0003003)3.63544074
10Cerebral hypomyelination (HP:0006808)3.57976775
11Progressive muscle weakness (HP:0003323)3.57768681
12Rough bone trabeculation (HP:0100670)3.38719734
13Nephroblastoma (Wilms tumor) (HP:0002667)3.32912799
14Patellar aplasia (HP:0006443)3.26410473
15Aplasia/Hypoplasia of the patella (HP:0006498)3.23974233
16Macrocytic anemia (HP:0001972)3.15994059
17Embryonal renal neoplasm (HP:0011794)3.09906735
18Aplasia/Hypoplasia of the earlobes (HP:0009906)3.05055065
19Absent radius (HP:0003974)3.03182979
20Oral leukoplakia (HP:0002745)2.93823330
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.89949548
22Absent forearm bone (HP:0003953)2.86321234
23Aplasia involving forearm bones (HP:0009822)2.86321234
24Trismus (HP:0000211)2.85539208
25Cellular immunodeficiency (HP:0005374)2.82122769
26Aplasia/hypoplasia of the uterus (HP:0008684)2.80500785
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77494223
28Abnormality of cells of the erythroid lineage (HP:0012130)2.77474151
29Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.73903662
30Abnormality of chromosome stability (HP:0003220)2.71104744
31Chromsome breakage (HP:0040012)2.69536700
32Abnormality of the labia minora (HP:0012880)2.69010186
33Abnormality of homocysteine metabolism (HP:0010919)2.68581147
34Homocystinuria (HP:0002156)2.68581147
35Selective tooth agenesis (HP:0001592)2.68070295
36Testicular atrophy (HP:0000029)2.67773474
37Exercise intolerance (HP:0003546)2.65884807
38Abnormal number of erythroid precursors (HP:0012131)2.62996905
39Granulocytopenia (HP:0001913)2.62376303
40Meckel diverticulum (HP:0002245)2.61791661
41Aplastic anemia (HP:0001915)2.60512181
42Hepatoblastoma (HP:0002884)2.60358644
43Increased nuchal translucency (HP:0010880)2.57808866
44Aplasia/Hypoplasia of the sacrum (HP:0008517)2.55801737
45Acute necrotizing encephalopathy (HP:0006965)2.55086418
46Cleft eyelid (HP:0000625)2.51819273
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.51422179
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.51422179
49Acanthocytosis (HP:0001927)2.51378438
50Supernumerary spleens (HP:0009799)2.46614245
51Supernumerary bones of the axial skeleton (HP:0009144)2.46490065
52Horseshoe kidney (HP:0000085)2.46389285
53Abnormal trabecular bone morphology (HP:0100671)2.46174379
54Neoplasm of the pancreas (HP:0002894)2.45993424
55Abnormal number of incisors (HP:0011064)2.45266169
56Microvesicular hepatic steatosis (HP:0001414)2.43647494
57Premature graying of hair (HP:0002216)2.42677461
58Abnormality of the ileum (HP:0001549)2.41473464
593-Methylglutaconic aciduria (HP:0003535)2.40966651
60Hepatocellular necrosis (HP:0001404)2.40260329
61Bilateral microphthalmos (HP:0007633)2.39462035
62Pallor (HP:0000980)2.38540654
63Aplasia/Hypoplasia involving the musculature (HP:0001460)2.36866546
64Aplasia/Hypoplasia of the sternum (HP:0006714)2.35810830
65Ependymoma (HP:0002888)2.32983735
66Absent thumb (HP:0009777)2.32235329
67Abnormality of cochlea (HP:0000375)2.31573115
68Acute lymphatic leukemia (HP:0006721)2.30834621
69Mitochondrial inheritance (HP:0001427)2.30774496
70Small intestinal stenosis (HP:0012848)2.30402738
71Duodenal stenosis (HP:0100867)2.30402738
72Medulloblastoma (HP:0002885)2.30294306
73Septo-optic dysplasia (HP:0100842)2.30288296
74Impulsivity (HP:0100710)2.30165810
75Secondary amenorrhea (HP:0000869)2.28619717
76Spinal muscular atrophy (HP:0007269)2.26097739
77Increased serum lactate (HP:0002151)2.25387148
78Abnormality of the carotid arteries (HP:0005344)2.24728015
79Fibular aplasia (HP:0002990)2.24419878
80Chronic bronchitis (HP:0004469)2.23600301
81Tracheoesophageal fistula (HP:0002575)2.22117462
82Stomach cancer (HP:0012126)2.20145575
83Broad alveolar ridges (HP:0000187)2.17761987
84Volvulus (HP:0002580)2.17425647
85Embryonal neoplasm (HP:0002898)2.17021645
86Abnormal mitochondria in muscle tissue (HP:0008316)2.14637141
87Neoplasm of the adrenal cortex (HP:0100641)2.13984381
88Rhabdomyosarcoma (HP:0002859)2.12192410
89Aplasia/hypoplasia of the humerus (HP:0006507)2.11313026
90Abnormality of the duodenum (HP:0002246)2.11186764
91Degeneration of anterior horn cells (HP:0002398)2.11100789
92Abnormality of the anterior horn cell (HP:0006802)2.11100789
93Supernumerary ribs (HP:0005815)2.10672005
94Triphalangeal thumb (HP:0001199)2.10200050
95Abdominal situs inversus (HP:0003363)2.09714630
96Abnormality of abdominal situs (HP:0011620)2.09714630
97Breast aplasia (HP:0100783)2.06375180
98Hypoplastic pelvis (HP:0008839)2.04221532
99Facial cleft (HP:0002006)2.04204538
100Ectopic kidney (HP:0000086)2.02652288
101Abnormality of the preputium (HP:0100587)2.02582757
102Agnosia (HP:0010524)2.00704952
103Gonadotropin excess (HP:0000837)2.00443525
104Glioma (HP:0009733)1.98346833
105Increased CSF lactate (HP:0002490)1.98218495
106Aplasia/Hypoplasia of the breasts (HP:0010311)1.97722683
107Attenuation of retinal blood vessels (HP:0007843)1.97144809
108Progressive macrocephaly (HP:0004481)1.97071807
109Morphological abnormality of the inner ear (HP:0011390)1.96300748
110Neoplasm of the oral cavity (HP:0100649)1.94975882
111Septate vagina (HP:0001153)1.94000051
112Glucose intolerance (HP:0000833)1.93055796
113Bone marrow hypocellularity (HP:0005528)1.92839596
114Midline defect of the nose (HP:0004122)1.92784188
115Abnormal lung lobation (HP:0002101)1.91371524
116Pancreatic islet-cell hyperplasia (HP:0004510)1.90571760
117Cholecystitis (HP:0001082)1.90233895
118Abnormal gallbladder physiology (HP:0012438)1.90233895
119Abnormality of reticulocytes (HP:0004312)1.89164339
120Hypoplasia of the radius (HP:0002984)1.88748586
121Myelodysplasia (HP:0002863)1.88192543
122Acute encephalopathy (HP:0006846)1.88137735
123Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87612895
124Respiratory failure (HP:0002878)1.86856564
125Fetal akinesia sequence (HP:0001989)1.86349676
126Unsteady gait (HP:0002317)1.82853563
127Premature ovarian failure (HP:0008209)1.81918885
128Overlapping toe (HP:0001845)1.81898208
129Facial hemangioma (HP:0000329)1.80213270
130Aplasia/Hypoplasia of the uvula (HP:0010293)1.79970850
131Asplenia (HP:0001746)1.79933178
132Anophthalmia (HP:0000528)1.78894815
133Atrophy/Degeneration involving motor neurons (HP:0007373)1.78843647
134Hepatic necrosis (HP:0002605)1.77288977
135Microretrognathia (HP:0000308)1.75627252
136Cortical dysplasia (HP:0002539)1.75188320
137Papillary thyroid carcinoma (HP:0002895)1.75150974
138Scrotal hypoplasia (HP:0000046)1.73794085
139Convex nasal ridge (HP:0000444)1.73067781
140Reticulocytosis (HP:0001923)1.72920179
141Duplication of thumb phalanx (HP:0009942)1.71797418
142Sloping forehead (HP:0000340)1.71741797
143Microglossia (HP:0000171)1.69800411
144Bifid tongue (HP:0010297)1.69227672
145Anal stenosis (HP:0002025)1.68817804
146Broad palm (HP:0001169)1.68722838
147Poikilocytosis (HP:0004447)1.68523509
148Abnormality of glycolysis (HP:0004366)1.68435310
149Abnormality of sulfur amino acid metabolism (HP:0004339)1.67491311
150Oligodactyly (hands) (HP:0001180)1.66305564
151Obsessive-compulsive behavior (HP:0000722)1.65146105
152Arteriovenous malformation (HP:0100026)1.64957649
153Hyperglycinemia (HP:0002154)1.64757245
154Neoplasm of striated muscle (HP:0009728)1.63118111
155Abnormality of methionine metabolism (HP:0010901)1.62760970
156Hemivertebrae (HP:0002937)1.62428410
157Ovarian neoplasm (HP:0100615)1.61852614
158Choanal atresia (HP:0000453)1.61821589
159Abnormality of the parathyroid morphology (HP:0011766)1.60818499
160Increased serum pyruvate (HP:0003542)1.60800492
161Hyperglycinuria (HP:0003108)1.60662998
162Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.60532864
163Absent epiphyses (HP:0010577)1.60532864
164Abnormality of DNA repair (HP:0003254)1.60139421
165Urethral obstruction (HP:0000796)1.58501691
166Vaginal fistula (HP:0004320)1.58054084
167Astrocytoma (HP:0009592)1.56156716
168Abnormality of the astrocytes (HP:0100707)1.56156716
169Cafe-au-lait spot (HP:0000957)1.55375914
170Biliary tract neoplasm (HP:0100574)1.54709782
171Myelomeningocele (HP:0002475)1.54363703
172Renal hypoplasia (HP:0000089)1.53084386
173Abnormality of serum amino acid levels (HP:0003112)1.52278049
174Osteomalacia (HP:0002749)1.52163230
175Breast carcinoma (HP:0003002)1.50705140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.34826696
2IRAK36.04113788
3BUB14.92080385
4MARK13.51435711
5SRPK13.33781124
6WEE13.18507400
7IRAK22.83490931
8IRAK42.70872958
9ZAK2.61474454
10FGFR22.48419206
11PNCK2.47283481
12TNIK2.41995834
13EIF2AK12.36865361
14TSSK62.35098723
15TTK2.26404710
16CDC72.18886263
17IRAK12.17144991
18TESK22.14502526
19CAMK1G1.85356954
20VRK11.84119135
21VRK21.81512658
22CAMK1D1.80773899
23EPHA21.77825402
24EEF2K1.75293228
25STK161.66362647
26NME11.60337717
27PLK31.51131669
28PAK41.49413671
29TLK11.45490261
30FGFR41.43829377
31PLK11.41566376
32WNK31.40524732
33TAF11.39012016
34PKN21.31285884
35NUAK11.30367475
36KDR1.29413297
37BRD41.25207567
38FGFR11.21574983
39BMPR1B1.19443192
40LATS21.17011511
41MST41.15526132
42ATR1.10572249
43MKNK21.08933202
44MAP3K101.08428235
45MKNK11.08420941
46CASK1.03976342
47AKT31.03836631
48MAP3K91.02799166
49TYRO31.01323434
50TRIM281.00409677
51CDK190.99622319
52MAP3K110.98522758
53WNK40.97859755
54PRKCI0.97710698
55EIF2AK30.95834534
56AURKA0.95298721
57STK38L0.93641500
58NEK20.90103421
59CHEK20.86967160
60MAP3K40.85549468
61ABL20.85372067
62CLK10.85060648
63CSNK1G10.81806369
64TRIB30.80157736
65STK30.79031199
66CHEK10.78920273
67CDK70.78743507
68DYRK30.75865158
69AURKB0.75511407
70CDK30.72525957
71NTRK30.71498175
72MINK10.70278537
73NTRK20.68697612
74MAP3K80.66803475
75SCYL20.66791889
76BCR0.65620254
77DYRK20.65545011
78ATM0.64639062
79RPS6KB20.63954533
80NLK0.63719389
81LATS10.63381583
82MTOR0.62903661
83STK40.62652656
84TESK10.60618753
85FGFR30.59745264
86* CDK20.59213287
87SGK20.58114285
88CDC42BPA0.57652963
89SGK4940.56948846
90SGK2230.56948846
91CSNK2A20.56800339
92STK390.56755077
93PLK20.56200319
94BRAF0.54007056
95PASK0.53882513
96CSNK1E0.53587254
97CSNK2A10.51044062
98SMG10.50567618
99ICK0.49171579
100PAK10.45810497
101CAMK2B0.45795906
102BMX0.44345176
103PBK0.44302573
104KSR10.43913660
105MUSK0.43908824
106CDK10.43840314
107CCNB10.42543144
108ALK0.42193471
109BMPR20.42120927
110RPS6KB10.41448701
111OXSR10.40265023
112ERBB20.40040336
113BRSK10.39702198
114ERBB30.38112583
115* PRKDC0.35834196
116DAPK10.35618642
117MAPK70.34248209
118EIF2AK20.33831114
119STK380.33450905
120CAMK2D0.33335282
121PINK10.33050825
122UHMK10.32900335
123STK100.32233960
124RPS6KA50.30653409
125NEK60.30047687
126PRPF4B0.29363010
127NEK10.27904309
128CAMK2G0.26506143
129BRSK20.23121087
130MAPK100.23117075
131BCKDK0.23013751
132LIMK10.22480079
133* GSK3B0.20622810
134CDK120.20151448
135MAPK90.19958414
136LRRK20.19077822
137GRK60.18874638
138NME20.18322866
139ROCK20.17069796
140CDK40.13491736
141AKT20.13199102
142PRKCG0.12905285
143* MAPK140.11831764
144MAPK40.11546225
145PIM10.11118693
146MELK0.10598846
147YES10.10393752

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030205.16644362
2Ribosome_Homo sapiens_hsa030104.63561828
3DNA replication_Homo sapiens_hsa030304.42484888
4Spliceosome_Homo sapiens_hsa030404.01621839
5Proteasome_Homo sapiens_hsa030503.84689873
6Mismatch repair_Homo sapiens_hsa034303.78656804
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.61921644
8Pyrimidine metabolism_Homo sapiens_hsa002403.42134807
9Steroid biosynthesis_Homo sapiens_hsa001002.88213196
10RNA transport_Homo sapiens_hsa030132.81626708
11Fanconi anemia pathway_Homo sapiens_hsa034602.49289254
12Homologous recombination_Homo sapiens_hsa034402.40626676
13Base excision repair_Homo sapiens_hsa034102.35355181
14Nucleotide excision repair_Homo sapiens_hsa034202.29036510
15One carbon pool by folate_Homo sapiens_hsa006702.22779282
16RNA degradation_Homo sapiens_hsa030182.21293630
17Oxidative phosphorylation_Homo sapiens_hsa001902.14673842
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01490816
19Huntingtons disease_Homo sapiens_hsa050161.91608664
20Parkinsons disease_Homo sapiens_hsa050121.89400640
21Purine metabolism_Homo sapiens_hsa002301.87655850
22Cell cycle_Homo sapiens_hsa041101.80901003
23Non-homologous end-joining_Homo sapiens_hsa034501.71810453
24Phenylalanine metabolism_Homo sapiens_hsa003601.49881190
25p53 signaling pathway_Homo sapiens_hsa041151.49820809
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.44567208
27Lysine degradation_Homo sapiens_hsa003101.42603006
28Selenocompound metabolism_Homo sapiens_hsa004501.40385319
29Propanoate metabolism_Homo sapiens_hsa006401.39353086
30mRNA surveillance pathway_Homo sapiens_hsa030151.37902042
31Basal transcription factors_Homo sapiens_hsa030221.36820339
32Epstein-Barr virus infection_Homo sapiens_hsa051691.33085652
33Alzheimers disease_Homo sapiens_hsa050101.24008901
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22607520
35Pyruvate metabolism_Homo sapiens_hsa006201.22215642
36Fatty acid biosynthesis_Homo sapiens_hsa000611.18633088
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18157015
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17717563
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10270460
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07406568
41Vitamin digestion and absorption_Homo sapiens_hsa049771.06271469
42Fatty acid metabolism_Homo sapiens_hsa012121.03485723
43Glutathione metabolism_Homo sapiens_hsa004801.02971576
44Protein export_Homo sapiens_hsa030600.94564999
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94488639
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.92576320
47Oocyte meiosis_Homo sapiens_hsa041140.92143675
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85308061
49N-Glycan biosynthesis_Homo sapiens_hsa005100.81227972
50Butanoate metabolism_Homo sapiens_hsa006500.79634366
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78440616
52Fatty acid elongation_Homo sapiens_hsa000620.73379495
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72049181
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71283262
55Adherens junction_Homo sapiens_hsa045200.70389016
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70366196
57Phototransduction_Homo sapiens_hsa047440.69244031
58Cardiac muscle contraction_Homo sapiens_hsa042600.67265504
59Systemic lupus erythematosus_Homo sapiens_hsa053220.65920700
60Arginine biosynthesis_Homo sapiens_hsa002200.63582394
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60513487
62Biosynthesis of amino acids_Homo sapiens_hsa012300.56660167
63Tyrosine metabolism_Homo sapiens_hsa003500.56462828
64Taste transduction_Homo sapiens_hsa047420.56145327
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54466104
66Viral carcinogenesis_Homo sapiens_hsa052030.49465460
67Endometrial cancer_Homo sapiens_hsa052130.47842987
68Thyroid cancer_Homo sapiens_hsa052160.43011343
69Nitrogen metabolism_Homo sapiens_hsa009100.42224522
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41930337
71Pentose phosphate pathway_Homo sapiens_hsa000300.41732952
72Metabolic pathways_Homo sapiens_hsa011000.41725936
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40120034
74Collecting duct acid secretion_Homo sapiens_hsa049660.39654301
75Folate biosynthesis_Homo sapiens_hsa007900.39141092
76Fat digestion and absorption_Homo sapiens_hsa049750.38897630
77HTLV-I infection_Homo sapiens_hsa051660.37917283
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37138253
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35670401
80Basal cell carcinoma_Homo sapiens_hsa052170.35314549
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.35030600
82Thyroid hormone synthesis_Homo sapiens_hsa049180.34673915
83Synaptic vesicle cycle_Homo sapiens_hsa047210.34452177
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34329073
85Alcoholism_Homo sapiens_hsa050340.33956378
86Peroxisome_Homo sapiens_hsa041460.33629490
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33385443
88AMPK signaling pathway_Homo sapiens_hsa041520.32457195
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30235301
90Vibrio cholerae infection_Homo sapiens_hsa051100.28975665
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27556532
92Hippo signaling pathway_Homo sapiens_hsa043900.27335914
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26787118
94Fructose and mannose metabolism_Homo sapiens_hsa000510.25850733
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25612506
96Notch signaling pathway_Homo sapiens_hsa043300.25497965
97ErbB signaling pathway_Homo sapiens_hsa040120.25225428
98Hedgehog signaling pathway_Homo sapiens_hsa043400.24416594
99Glucagon signaling pathway_Homo sapiens_hsa049220.22785589
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21522534
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20845930
102MicroRNAs in cancer_Homo sapiens_hsa052060.19913410
103Herpes simplex infection_Homo sapiens_hsa051680.19367813
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18858835
105Tight junction_Homo sapiens_hsa045300.17604283
106Wnt signaling pathway_Homo sapiens_hsa043100.16819477
107HIF-1 signaling pathway_Homo sapiens_hsa040660.16255371
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15251823
109Nicotine addiction_Homo sapiens_hsa050330.14307954
110Melanoma_Homo sapiens_hsa052180.12895277
111Pathways in cancer_Homo sapiens_hsa052000.12708730
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10967866
113Linoleic acid metabolism_Homo sapiens_hsa005910.10735477
114Arachidonic acid metabolism_Homo sapiens_hsa005900.10729667
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.10018881
116Vitamin B6 metabolism_Homo sapiens_hsa007500.09896765
117Carbon metabolism_Homo sapiens_hsa012000.09393049
118Arginine and proline metabolism_Homo sapiens_hsa003300.09261576
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08977080
120TGF-beta signaling pathway_Homo sapiens_hsa043500.08516179
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.07809524
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.07154969
123Colorectal cancer_Homo sapiens_hsa052100.05848451
124Shigellosis_Homo sapiens_hsa051310.03985008
125Sphingolipid metabolism_Homo sapiens_hsa006000.03213111
126Prion diseases_Homo sapiens_hsa050200.03186389
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.02506146
128Galactose metabolism_Homo sapiens_hsa000520.01972886
129Melanogenesis_Homo sapiens_hsa049160.00317501
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0427013
131FoxO signaling pathway_Homo sapiens_hsa04068-0.0387901
132Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0357881
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210-0.0350282
134Prostate cancer_Homo sapiens_hsa05215-0.0261791
135Small cell lung cancer_Homo sapiens_hsa05222-0.0166488
136Acute myeloid leukemia_Homo sapiens_hsa05221-0.0027933
137Ether lipid metabolism_Homo sapiens_hsa00565-0.0012504

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