ZNF10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)4.69396185
2regulation of meiosis I (GO:0060631)4.20124796
3axoneme assembly (GO:0035082)3.98660402
4presynaptic membrane assembly (GO:0097105)3.95925337
5brain morphogenesis (GO:0048854)3.82073193
6behavioral response to nicotine (GO:0035095)3.78011520
7DNA methylation involved in gamete generation (GO:0043046)3.65639495
8nucleobase catabolic process (GO:0046113)3.63316196
9acrosome reaction (GO:0007340)3.63161244
10response to pheromone (GO:0019236)3.57927378
11epithelial cilium movement (GO:0003351)3.49254623
12pyrimidine nucleobase catabolic process (GO:0006208)3.47861776
13regulation of timing of cell differentiation (GO:0048505)3.44992802
14protein localization to cilium (GO:0061512)3.40880637
15presynaptic membrane organization (GO:0097090)3.39880570
16inositol phosphate catabolic process (GO:0071545)3.39508367
17synapsis (GO:0007129)3.36474219
18detection of calcium ion (GO:0005513)3.33551064
19regulation of development, heterochronic (GO:0040034)3.15137632
20male meiosis (GO:0007140)3.11712931
21retinal ganglion cell axon guidance (GO:0031290)3.09525549
22male meiosis I (GO:0007141)3.08115875
23neuron cell-cell adhesion (GO:0007158)3.00143550
24response to lipoprotein particle (GO:0055094)2.99938683
25inositol phosphate dephosphorylation (GO:0046855)2.99097301
26phosphorylated carbohydrate dephosphorylation (GO:0046838)2.99097301
27intraciliary transport (GO:0042073)2.97319637
28regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.96770089
29cilium movement (GO:0003341)2.95940060
30neuron fate determination (GO:0048664)2.94619709
31positive regulation of meiosis (GO:0045836)2.92991822
32cilium morphogenesis (GO:0060271)2.90666427
33establishment of protein localization to Golgi (GO:0072600)2.90378213
34regulation of DNA endoreduplication (GO:0032875)2.90170025
35dentate gyrus development (GO:0021542)2.89669224
36protein targeting to Golgi (GO:0000042)2.89630035
37neurofilament cytoskeleton organization (GO:0060052)2.83910008
38kidney morphogenesis (GO:0060993)2.81557830
39nonmotile primary cilium assembly (GO:0035058)2.81376638
40DNA double-strand break processing (GO:0000729)2.75257742
41synaptonemal complex organization (GO:0070193)2.73889238
42dendritic spine morphogenesis (GO:0060997)2.72541265
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72260938
44resolution of meiotic recombination intermediates (GO:0000712)2.72028794
45central nervous system neuron axonogenesis (GO:0021955)2.71874848
46negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70899370
47axonal fasciculation (GO:0007413)2.68178866
48positive regulation of meiotic cell cycle (GO:0051446)2.68168965
49chromosome organization involved in meiosis (GO:0070192)2.65918481
50regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.64563218
51cilium organization (GO:0044782)2.61256070
52cilium assembly (GO:0042384)2.59767488
53polyol catabolic process (GO:0046174)2.58953969
54chemosensory behavior (GO:0007635)2.58819258
55photoreceptor cell maintenance (GO:0045494)2.57676339
56synaptonemal complex assembly (GO:0007130)2.57417247
57cardiac left ventricle morphogenesis (GO:0003214)2.57269104
58protein localization to Golgi apparatus (GO:0034067)2.56438308
59pyrimidine dimer repair (GO:0006290)2.56382773
60retrograde transport, vesicle recycling within Golgi (GO:0000301)2.55689133
61central nervous system projection neuron axonogenesis (GO:0021952)2.55094080
62mitotic sister chromatid cohesion (GO:0007064)2.53918237
63histone H2A ubiquitination (GO:0033522)2.53056965
64negative regulation of protein oligomerization (GO:0032460)2.51437784
65protein polyglutamylation (GO:0018095)2.49144835
66establishment of nucleus localization (GO:0040023)2.48495070
67neuron recognition (GO:0008038)2.48299689
68neural tube formation (GO:0001841)2.47153741
69forebrain morphogenesis (GO:0048853)2.46642476
70platelet dense granule organization (GO:0060155)2.44675572
71forebrain neuron differentiation (GO:0021879)2.43972365
72negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.43310525
73negative regulation of translation, ncRNA-mediated (GO:0040033)2.43310525
74regulation of translation, ncRNA-mediated (GO:0045974)2.43310525
75regulation of hexokinase activity (GO:1903299)2.43224986
76regulation of glucokinase activity (GO:0033131)2.43224986
77negative regulation of DNA-dependent DNA replication (GO:2000104)2.42582112
78positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.40823708
79detection of light stimulus involved in visual perception (GO:0050908)2.40754026
80detection of light stimulus involved in sensory perception (GO:0050962)2.40754026
81retinal cone cell development (GO:0046549)2.40002168
82cellular ketone body metabolic process (GO:0046950)2.39721849
83microtubule anchoring (GO:0034453)2.39528556
84calcium ion-dependent exocytosis (GO:0017156)2.38499207
85regulation of collateral sprouting (GO:0048670)2.37523377
86negative regulation of cytosolic calcium ion concentration (GO:0051481)2.37126548
87protein prenylation (GO:0018342)2.37083928
88prenylation (GO:0097354)2.37083928
89microtubule bundle formation (GO:0001578)2.35968510
90transmission of nerve impulse (GO:0019226)2.33930474
91positive regulation of oligodendrocyte differentiation (GO:0048714)2.33476377
92reciprocal DNA recombination (GO:0035825)2.32923722
93reciprocal meiotic recombination (GO:0007131)2.32923722
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.32840839
95gene silencing by RNA (GO:0031047)2.32142401
96sister chromatid cohesion (GO:0007062)2.29768583
97vocalization behavior (GO:0071625)2.28521917
98cornea development in camera-type eye (GO:0061303)2.27512029
99pancreas development (GO:0031016)2.26698127
100regulation of cilium movement (GO:0003352)2.26475502

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.51430739
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.45894811
3ZNF274_21170338_ChIP-Seq_K562_Hela2.95786653
4GBX2_23144817_ChIP-Seq_PC3_Human2.80713841
5IGF1R_20145208_ChIP-Seq_DFB_Human2.79296567
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.79149797
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67836566
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.63734208
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.60290244
10FUS_26573619_Chip-Seq_HEK293_Human2.49630589
11VDR_22108803_ChIP-Seq_LS180_Human2.39746937
12TAF15_26573619_Chip-Seq_HEK293_Human2.38068960
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35499999
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.34283271
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24161461
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13766824
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.08748275
18P300_19829295_ChIP-Seq_ESCs_Human2.07111687
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02931443
20EWS_26573619_Chip-Seq_HEK293_Human1.98279859
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92577197
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84911625
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79873944
24SMAD4_21799915_ChIP-Seq_A2780_Human1.77675331
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76799043
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74244545
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72302761
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.71497735
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.69592505
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.69542881
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64551993
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63922517
33ER_23166858_ChIP-Seq_MCF-7_Human1.62491165
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.60681503
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60072433
36RNF2_27304074_Chip-Seq_NSC_Mouse1.59720536
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58929246
38AR_25329375_ChIP-Seq_VCAP_Human1.58404639
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57153426
40BCAT_22108803_ChIP-Seq_LS180_Human1.56189614
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55996049
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55871700
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52969410
44* STAT3_23295773_ChIP-Seq_U87_Human1.50696489
45CBP_20019798_ChIP-Seq_JUKART_Human1.50375994
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50375994
47REST_21632747_ChIP-Seq_MESCs_Mouse1.45854642
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.45282998
49* TCF4_23295773_ChIP-Seq_U87_Human1.43008192
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40512431
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38159529
52AR_21572438_ChIP-Seq_LNCaP_Human1.38048892
53RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32637636
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32319144
55RUNX2_22187159_ChIP-Seq_PCA_Human1.31246171
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30957770
57TCF4_22108803_ChIP-Seq_LS180_Human1.30658287
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.30411572
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29242471
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29242471
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28034234
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27041204
63TP53_22573176_ChIP-Seq_HFKS_Human1.26910156
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24830740
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.24068741
66HTT_18923047_ChIP-ChIP_STHdh_Human1.20161797
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19887951
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18971711
69SOX2_19829295_ChIP-Seq_ESCs_Human1.18829566
70NANOG_19829295_ChIP-Seq_ESCs_Human1.18829566
71* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18492056
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.17707933
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17390364
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14285663
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.13445582
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12701726
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.12295563
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11362766
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.09603247
80IRF1_19129219_ChIP-ChIP_H3396_Human1.09165117
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.08854048
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08604921
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06785683
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.04374834
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.03206920
86* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02508552
87REST_18959480_ChIP-ChIP_MESCs_Mouse1.01905505
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.01275127
89P53_22387025_ChIP-Seq_ESCs_Mouse1.00572399
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00089658
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99580849
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.99106394
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99082777
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97502372
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97428947
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.97407768
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96795809
98CMYC_18555785_Chip-Seq_ESCs_Mouse0.95614610
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94935706
100CDX2_22108803_ChIP-Seq_LS180_Human0.94754721

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.06302466
2MP0003787_abnormal_imprinting4.82409782
3MP0003195_calcinosis3.91099304
4MP0003121_genomic_imprinting2.74724912
5MP0003122_maternal_imprinting2.55533844
6MP0002638_abnormal_pupillary_reflex2.36225919
7MP0010386_abnormal_urinary_bladder2.34768314
8MP0003123_paternal_imprinting2.24225428
9MP0002837_dystrophic_cardiac_calcinosis2.11225866
10MP0005645_abnormal_hypothalamus_physiol1.98617851
11MP0001984_abnormal_olfaction1.96834936
12MP0000778_abnormal_nervous_system1.92209941
13MP0000631_abnormal_neuroendocrine_gland1.92104348
14MP0006276_abnormal_autonomic_nervous1.88220528
15MP0006072_abnormal_retinal_apoptosis1.85892255
16MP0008995_early_reproductive_senescence1.83241556
17MP0004270_analgesia1.82039681
18MP0003880_abnormal_central_pattern1.76816968
19MP0005646_abnormal_pituitary_gland1.71602410
20MP0002272_abnormal_nervous_system1.65280089
21MP0005551_abnormal_eye_electrophysiolog1.64979799
22MP0002653_abnormal_ependyma_morphology1.64179486
23MP0009046_muscle_twitch1.63875677
24MP0002102_abnormal_ear_morphology1.63238770
25MP0005253_abnormal_eye_physiology1.53515343
26MP0009745_abnormal_behavioral_response1.51740915
27MP0000516_abnormal_urinary_system1.47765318
28MP0005367_renal/urinary_system_phenotyp1.47765318
29MP0002734_abnormal_mechanical_nocicepti1.43152498
30MP0008058_abnormal_DNA_repair1.43048067
31MP0008789_abnormal_olfactory_epithelium1.41853909
32MP0000569_abnormal_digit_pigmentation1.40810631
33MP0002163_abnormal_gland_morphology1.40748622
34MP0006292_abnormal_olfactory_placode1.38473086
35MP0003890_abnormal_embryonic-extraembry1.36515632
36MP0005379_endocrine/exocrine_gland_phen1.34955184
37MP0002210_abnormal_sex_determination1.32885975
38MP0002064_seizures1.31852702
39MP0001486_abnormal_startle_reflex1.31453652
40MP0003718_maternal_effect1.30982914
41MP0002909_abnormal_adrenal_gland1.29484289
42MP0004885_abnormal_endolymph1.28011348
43MP0002160_abnormal_reproductive_system1.25400080
44MP0002572_abnormal_emotion/affect_behav1.25232523
45MP0002063_abnormal_learning/memory/cond1.24830705
46MP0003635_abnormal_synaptic_transmissio1.24198657
47MP0002557_abnormal_social/conspecific_i1.23543990
48MP0001929_abnormal_gametogenesis1.23311380
49MP0001968_abnormal_touch/_nociception1.22718530
50MP0003698_abnormal_male_reproductive1.22158771
51MP0001529_abnormal_vocalization1.21472846
52MP0003119_abnormal_digestive_system1.20400958
53MP0005394_taste/olfaction_phenotype1.20058446
54MP0005499_abnormal_olfactory_system1.20058446
55MP0002736_abnormal_nociception_after1.19407648
56MP0000653_abnormal_sex_gland1.18873327
57MP0001145_abnormal_male_reproductive1.16489882
58MP0004043_abnormal_pH_regulation1.15135254
59MP0003011_delayed_dark_adaptation1.13956477
60MP0000955_abnormal_spinal_cord1.13603182
61MP0002928_abnormal_bile_duct1.09631274
62MP0004142_abnormal_muscle_tone1.06796488
63MP0001986_abnormal_taste_sensitivity1.06469085
64MP0002067_abnormal_sensory_capabilities1.04264375
65MP0000427_abnormal_hair_cycle1.02922541
66MP0002735_abnormal_chemical_nociception1.01169409
67MP0005423_abnormal_somatic_nervous0.99416338
68MP0004924_abnormal_behavior0.98988753
69MP0005386_behavior/neurological_phenoty0.98988753
70MP0002184_abnormal_innervation0.98434624
71MP0002938_white_spotting0.95988606
72MP0005220_abnormal_exocrine_pancreas0.92824616
73MP0005389_reproductive_system_phenotype0.92553604
74MP0002882_abnormal_neuron_morphology0.91913332
75MP0003136_yellow_coat_color0.91284188
76MP0001970_abnormal_pain_threshold0.90506505
77MP0001501_abnormal_sleep_pattern0.90126915
78MP0010234_abnormal_vibrissa_follicle0.90126509
79MP0005195_abnormal_posterior_eye0.89280752
80MP0004133_heterotaxia0.88519195
81MP0001944_abnormal_pancreas_morphology0.87997058
82MP0004811_abnormal_neuron_physiology0.87978875
83MP0002751_abnormal_autonomic_nervous0.86305734
84MP0000538_abnormal_urinary_bladder0.82199722
85MP0002752_abnormal_somatic_nervous0.82093579
86MP0002229_neurodegeneration0.81600373
87MP0005395_other_phenotype0.80932181
88MP0008875_abnormal_xenobiotic_pharmacok0.80483651
89MP0002152_abnormal_brain_morphology0.80126972
90MP0002876_abnormal_thyroid_physiology0.79588880
91MP0002090_abnormal_vision0.79104360
92MP0001440_abnormal_grooming_behavior0.78546671
93MP0001177_atelectasis0.78414290
94MP0005187_abnormal_penis_morphology0.74590092
95MP0009780_abnormal_chondrocyte_physiolo0.73649764
96MP0003861_abnormal_nervous_system0.72841585
97MP0004859_abnormal_synaptic_plasticity0.71894365
98MP0002161_abnormal_fertility/fecundity0.69985776
99MP0000013_abnormal_adipose_tissue0.69524147
100MP0003786_premature_aging0.69471050

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.36499546
2Volvulus (HP:0002580)4.12403994
3Intestinal atresia (HP:0011100)3.79475468
4Medial flaring of the eyebrow (HP:0010747)3.59858133
5Gait imbalance (HP:0002141)3.19702459
6Nephronophthisis (HP:0000090)3.18787724
7Neoplasm of the adrenal cortex (HP:0100641)3.07302819
8Congenital primary aphakia (HP:0007707)2.99782728
9Pancreatic fibrosis (HP:0100732)2.96613815
10Molar tooth sign on MRI (HP:0002419)2.92498647
11Abnormality of midbrain morphology (HP:0002418)2.92498647
12Nephrogenic diabetes insipidus (HP:0009806)2.91355851
13Abnormal drinking behavior (HP:0030082)2.88453897
14Polydipsia (HP:0001959)2.88453897
15Genital tract atresia (HP:0001827)2.86733467
16Pancreatic cysts (HP:0001737)2.86276070
17True hermaphroditism (HP:0010459)2.73725263
18Increased circulating renin level (HP:0000848)2.72394391
19Vaginal atresia (HP:0000148)2.67227897
20Hypomagnesemia (HP:0002917)2.59731851
21Abnormality of the renal medulla (HP:0100957)2.57321556
22Abnormality of the metopic suture (HP:0005556)2.54995230
23Hypothermia (HP:0002045)2.51030834
24Metaphyseal dysplasia (HP:0100255)2.50212667
25Gastrointestinal atresia (HP:0002589)2.43274041
26Chronic hepatic failure (HP:0100626)2.37560726
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.36684927
28Degeneration of the lateral corticospinal tracts (HP:0002314)2.36684927
29Hepatoblastoma (HP:0002884)2.30186976
30Abnormality of the corticospinal tract (HP:0002492)2.29945452
31Hyperventilation (HP:0002883)2.27657012
32Abnormal rod and cone electroretinograms (HP:0008323)2.27340446
33Methylmalonic acidemia (HP:0002912)2.23329897
34Prominent metopic ridge (HP:0005487)2.20825976
35Macroorchidism (HP:0000053)2.19251095
36Broad-based gait (HP:0002136)2.16701041
37Postaxial hand polydactyly (HP:0001162)2.14413965
38Polyuria (HP:0000103)2.09587283
39Poor coordination (HP:0002370)2.05745628
40Abnormality of the renal cortex (HP:0011035)2.03825799
41Tachypnea (HP:0002789)2.03199531
42Drooling (HP:0002307)2.00189669
43Optic nerve hypoplasia (HP:0000609)1.99808984
44Progressive cerebellar ataxia (HP:0002073)1.99703148
45Scrotal hypoplasia (HP:0000046)1.97580295
46Abnormality of the pancreatic islet cells (HP:0006476)1.96447489
47Abnormality of endocrine pancreas physiology (HP:0012093)1.96447489
48Hyperglycinemia (HP:0002154)1.96037351
49Bony spicule pigmentary retinopathy (HP:0007737)1.94856808
50Male pseudohermaphroditism (HP:0000037)1.93767293
51Congenital stationary night blindness (HP:0007642)1.90659925
52Aplasia/Hypoplasia of the tongue (HP:0010295)1.90217632
53Febrile seizures (HP:0002373)1.89795370
54Cystic liver disease (HP:0006706)1.88170570
55Neoplasm of the oral cavity (HP:0100649)1.87874260
56Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87059529
57Hypsarrhythmia (HP:0002521)1.86720554
58Multicystic kidney dysplasia (HP:0000003)1.85891764
59Broad alveolar ridges (HP:0000187)1.84880022
60Colon cancer (HP:0003003)1.84836593
61Large for gestational age (HP:0001520)1.83792835
62Focal seizures (HP:0007359)1.83110101
63Septo-optic dysplasia (HP:0100842)1.82735153
64Neoplasm of the adrenal gland (HP:0100631)1.82384749
65Hypochromic microcytic anemia (HP:0004840)1.82315792
66EEG with generalized epileptiform discharges (HP:0011198)1.82295619
67Narrow forehead (HP:0000341)1.82227755
68Specific learning disability (HP:0001328)1.80947767
69Abnormal hair whorl (HP:0010721)1.80404595
70Hypoplasia of the fovea (HP:0007750)1.79193379
71Aplasia/Hypoplasia of the fovea (HP:0008060)1.79193379
72Agitation (HP:0000713)1.78516399
73Excessive salivation (HP:0003781)1.76557212
74Amyotrophic lateral sclerosis (HP:0007354)1.76272633
75Epileptiform EEG discharges (HP:0011182)1.75964370
76Attenuation of retinal blood vessels (HP:0007843)1.75726735
77Absent eyebrow (HP:0002223)1.75648951
78Fair hair (HP:0002286)1.75536654
79Short foot (HP:0001773)1.74730991
80Prominent nasal bridge (HP:0000426)1.74250091
81Dynein arm defect of respiratory motile cilia (HP:0012255)1.73804084
82Absent/shortened dynein arms (HP:0200106)1.73804084
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73765749
84Postaxial foot polydactyly (HP:0001830)1.72766260
85Dialeptic seizures (HP:0011146)1.72252956
86Astigmatism (HP:0000483)1.71538954
87Tubular atrophy (HP:0000092)1.70687157
88Hyperphosphatemia (HP:0002905)1.69765948
89Abolished electroretinogram (ERG) (HP:0000550)1.67280532
90Micropenis (HP:0000054)1.65543724
91Abnormal urine output (HP:0012590)1.65091583
92Lissencephaly (HP:0001339)1.64903183
93Epidermoid cyst (HP:0200040)1.63203328
94Protruding tongue (HP:0010808)1.63129372
95Vacuolated lymphocytes (HP:0001922)1.62234807
96Abnormality of renal excretion (HP:0011036)1.60460832
97Abnormality of magnesium homeostasis (HP:0004921)1.59935306
98Abnormal ciliary motility (HP:0012262)1.59758902
99Supernumerary spleens (HP:0009799)1.59677227
100Focal motor seizures (HP:0011153)1.59576313

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.32567995
2CASK3.50098081
3MARK13.38267834
4WNK33.25009420
5MAP3K42.68240988
6NUAK12.54938780
7FGFR22.45311093
8MAPK132.38192072
9PNCK2.00894654
10MAP2K71.93693221
11NTRK31.92609477
12TNIK1.85693212
13TRIM281.84384602
14ACVR1B1.82194716
15LATS11.80440808
16MAP4K21.76026087
17PINK11.71194522
18STK38L1.70264739
19BMPR1B1.66853607
20DYRK21.51700667
21PAK31.40892583
22CSNK1G21.38049532
23OXSR11.33837888
24PASK1.32262698
25CSNK1G31.27096614
26CSNK1G11.25540329
27STK31.24329325
28MKNK21.19447748
29PRKCG1.17051619
30BCR1.16432768
31CDK191.15414454
32PLK41.09974745
33WNK41.08603550
34PHKG21.07952523
35PHKG11.07952523
36ZAK1.07615131
37ADRBK21.07348326
38INSRR1.06003249
39STK391.04882586
40PLK21.04579601
41CSNK1A1L1.03341942
42UHMK11.01127915
43TSSK61.00698915
44GRK10.98247258
45MAP2K40.97210181
46NTRK20.93446529
47CDK30.91231085
48MST40.87229300
49PLK30.85986548
50BRD40.83563309
51DAPK20.82699411
52ERBB30.81864570
53SGK20.79393891
54STK110.78097220
55VRK10.77940745
56DYRK30.77491108
57MKNK10.77479415
58YES10.76371870
59MAP2K60.76359583
60DYRK1A0.75989952
61EPHA40.75931901
62PRKCE0.73350966
63MAPK150.72492302
64SIK20.70918734
65AKT30.69044593
66PKN10.66396428
67MINK10.65980325
68EIF2AK30.65919688
69ATM0.60247784
70SGK2230.50731951
71SGK4940.50731951
72PLK10.50410166
73ATR0.48663403
74CAMK2A0.47908623
75CDK50.46371221
76LIMK10.46236913
77TAOK10.45843405
78PRKG10.45262580
79PRKAA10.43454597
80MAP3K50.42559510
81FER0.42543681
82CSNK1E0.42348035
83PRKACA0.41814312
84CSNK1D0.41131396
85IRAK10.39820238
86PTK2B0.39586120
87CSNK1A10.38993920
88PRKACB0.37771624
89STK380.37407320
90SRPK10.37373694
91FLT30.37277523
92DYRK1B0.37052986
93EPHA30.36796630
94CAMK10.35642401
95PRKDC0.34557692
96OBSCN0.33705442
97STK40.31671352
98PRKCZ0.29997060
99TAF10.29565053
100NLK0.28379342

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.85776622
2Vitamin B6 metabolism_Homo sapiens_hsa007503.44907790
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.21995515
4Butanoate metabolism_Homo sapiens_hsa006502.91196148
5Protein export_Homo sapiens_hsa030602.78808514
6Nicotine addiction_Homo sapiens_hsa050332.73477343
7Basal transcription factors_Homo sapiens_hsa030222.67818210
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.49611148
9Propanoate metabolism_Homo sapiens_hsa006402.10437320
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06493464
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03081472
12Phototransduction_Homo sapiens_hsa047442.00898571
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90524355
14Steroid biosynthesis_Homo sapiens_hsa001001.84707376
15Oxidative phosphorylation_Homo sapiens_hsa001901.82637885
16Regulation of autophagy_Homo sapiens_hsa041401.73982850
17Fanconi anemia pathway_Homo sapiens_hsa034601.69168156
18Insulin secretion_Homo sapiens_hsa049111.52424151
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48136301
20GABAergic synapse_Homo sapiens_hsa047271.43143454
21Parkinsons disease_Homo sapiens_hsa050121.42087068
22RNA degradation_Homo sapiens_hsa030181.32165337
23Circadian rhythm_Homo sapiens_hsa047101.28151374
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21443037
25Peroxisome_Homo sapiens_hsa041461.20599653
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19307178
27Taste transduction_Homo sapiens_hsa047421.15683686
28Circadian entrainment_Homo sapiens_hsa047131.09687582
29Huntingtons disease_Homo sapiens_hsa050161.08221085
30Morphine addiction_Homo sapiens_hsa050321.07745824
31Glutamatergic synapse_Homo sapiens_hsa047241.07050052
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05612105
33Collecting duct acid secretion_Homo sapiens_hsa049661.01987921
34Homologous recombination_Homo sapiens_hsa034401.01334425
35Fatty acid metabolism_Homo sapiens_hsa012121.00845865
36RNA polymerase_Homo sapiens_hsa030201.00416649
37Amphetamine addiction_Homo sapiens_hsa050311.00193700
38Tryptophan metabolism_Homo sapiens_hsa003800.99971100
39Cardiac muscle contraction_Homo sapiens_hsa042600.99888303
40Primary bile acid biosynthesis_Homo sapiens_hsa001200.98973462
41Fatty acid elongation_Homo sapiens_hsa000620.97547854
42Dopaminergic synapse_Homo sapiens_hsa047280.97343708
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95380042
44Linoleic acid metabolism_Homo sapiens_hsa005910.94958382
45Fatty acid degradation_Homo sapiens_hsa000710.91290587
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90163257
47Ether lipid metabolism_Homo sapiens_hsa005650.90098784
48Serotonergic synapse_Homo sapiens_hsa047260.89151794
49Folate biosynthesis_Homo sapiens_hsa007900.86076403
50beta-Alanine metabolism_Homo sapiens_hsa004100.84716752
51Non-homologous end-joining_Homo sapiens_hsa034500.84713837
52Oocyte meiosis_Homo sapiens_hsa041140.84508870
53Synaptic vesicle cycle_Homo sapiens_hsa047210.84449564
54Alzheimers disease_Homo sapiens_hsa050100.82172486
55Olfactory transduction_Homo sapiens_hsa047400.79495111
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77804537
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77800772
58Type II diabetes mellitus_Homo sapiens_hsa049300.76985272
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76632511
60Cocaine addiction_Homo sapiens_hsa050300.75464905
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74950759
62Retinol metabolism_Homo sapiens_hsa008300.74548171
63Caffeine metabolism_Homo sapiens_hsa002320.73368569
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72315491
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72176455
66Ovarian steroidogenesis_Homo sapiens_hsa049130.71332409
67ABC transporters_Homo sapiens_hsa020100.70906121
68Hedgehog signaling pathway_Homo sapiens_hsa043400.67580383
69Long-term depression_Homo sapiens_hsa047300.62412114
70Purine metabolism_Homo sapiens_hsa002300.61187902
71Nucleotide excision repair_Homo sapiens_hsa034200.60163918
72Metabolic pathways_Homo sapiens_hsa011000.55592773
73Selenocompound metabolism_Homo sapiens_hsa004500.55549587
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54880352
75Lysine degradation_Homo sapiens_hsa003100.54292812
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54120064
77Dorso-ventral axis formation_Homo sapiens_hsa043200.53592846
78Mismatch repair_Homo sapiens_hsa034300.53385483
79Renin secretion_Homo sapiens_hsa049240.53048304
80Chemical carcinogenesis_Homo sapiens_hsa052040.52834220
81Axon guidance_Homo sapiens_hsa043600.52362217
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51523937
83mRNA surveillance pathway_Homo sapiens_hsa030150.48460062
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47857204
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47572319
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47093810
87Cholinergic synapse_Homo sapiens_hsa047250.47044207
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.45909102
89Basal cell carcinoma_Homo sapiens_hsa052170.44602171
90Hippo signaling pathway_Homo sapiens_hsa043900.44475767
91Nitrogen metabolism_Homo sapiens_hsa009100.42943575
92Salivary secretion_Homo sapiens_hsa049700.42848703
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42368710
94RNA transport_Homo sapiens_hsa030130.42241580
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41357232
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.40328977
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37083017
98Sphingolipid metabolism_Homo sapiens_hsa006000.36836935
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35680896
100cAMP signaling pathway_Homo sapiens_hsa040240.31951994

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »