ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.59804815
2	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.74658386
3	L-fucose catabolic process (GO:0042355)	3.74616462
4	fucose catabolic process (GO:0019317)	3.74616462
5	L-fucose metabolic process (GO:0042354)	3.74616462
6	replication fork processing (GO:0031297)	3.71517242
7	DNA double-strand break processing (GO:0000729)	3.64436708
8	kynurenine metabolic process (GO:0070189)	3.38819930
9	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.37205131
10	recombinational repair (GO:0000725)	3.33152809
11	tryptophan catabolic process (GO:0006569)	3.29370419
12	indole-containing compound catabolic process (GO:0042436)	3.29370419
13	indolalkylamine catabolic process (GO:0046218)	3.29370419
14	double-strand break repair via homologous recombination (GO:0000724)	3.28451956
15	neural tube formation (GO:0001841)	3.26954764
16	regulation of DNA endoreduplication (GO:0032875)	3.25096235
17	response to pheromone (GO:0019236)	3.24261413
18	centriole replication (GO:0007099)	3.22825422
19	resolution of meiotic recombination intermediates (GO:0000712)	3.20619463
20	DNA deamination (GO:0045006)	3.17087149
21	chromatin remodeling at centromere (GO:0031055)	3.15953102
22	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.15080250
23	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.13206038
24	sulfation (GO:0051923)	3.13153266
25	indolalkylamine metabolic process (GO:0006586)	3.11290442
26	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.10187163
27	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.09639244
28	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.03747640
29	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.03747640
30	water-soluble vitamin biosynthetic process (GO:0042364)	3.00953299
31	regulation of mitotic spindle checkpoint (GO:1903504)	2.98987774
32	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.98987774
33	CENP-A containing nucleosome assembly (GO:0034080)	2.98425065
34	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.98102465
35	regulation of translation, ncRNA-mediated (GO:0045974)	2.98102465
36	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.98102465
37	protein polyglutamylation (GO:0018095)	2.97317691
38	mitochondrial respiratory chain complex assembly (GO:0033108)	2.95130181
39	protein complex biogenesis (GO:0070271)	2.95092882
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.94649470
41	NADH dehydrogenase complex assembly (GO:0010257)	2.94649470
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.94649470
43	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.94407706
44	regulation of gene silencing by miRNA (GO:0060964)	2.93119823
45	regulation of gene silencing by RNA (GO:0060966)	2.93119823
46	regulation of posttranscriptional gene silencing (GO:0060147)	2.93119823
47	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.92296561
48	rRNA catabolic process (GO:0016075)	2.86105378
49	kidney morphogenesis (GO:0060993)	2.83702934
50	tryptophan metabolic process (GO:0006568)	2.82166589
51	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.81929018
52	synapsis (GO:0007129)	2.80672562
53	histone exchange (GO:0043486)	2.80271293
54	reciprocal meiotic recombination (GO:0007131)	2.77349964
55	reciprocal DNA recombination (GO:0035825)	2.77349964
56	protein K6-linked ubiquitination (GO:0085020)	2.74977953
57	ncRNA catabolic process (GO:0034661)	2.64935709
58	meiotic chromosome segregation (GO:0045132)	2.60614908
59	prenylation (GO:0097354)	2.60374203
60	protein prenylation (GO:0018342)	2.60374203
61	respiratory chain complex IV assembly (GO:0008535)	2.59767200
62	piRNA metabolic process (GO:0034587)	2.59248239
63	regulation of telomere maintenance (GO:0032204)	2.58865833
64	DNA replication checkpoint (GO:0000076)	2.58701165
65	hindbrain development (GO:0030902)	2.56998519
66	negative regulation of telomere maintenance (GO:0032205)	2.55700775
67	platelet dense granule organization (GO:0060155)	2.53863957
68	DNA demethylation (GO:0080111)	2.53275051
69	protein-cofactor linkage (GO:0018065)	2.51871754
70	maturation of 5.8S rRNA (GO:0000460)	2.50750515
71	regulation of centriole replication (GO:0046599)	2.50301988
72	preassembly of GPI anchor in ER membrane (GO:0016254)	2.48636364
73	epithelial cilium movement (GO:0003351)	2.48510794
74	regulation of meiosis I (GO:0060631)	2.46952284
75	male meiosis I (GO:0007141)	2.45274004
76	reflex (GO:0060004)	2.44913503
77	microtubule anchoring (GO:0034453)	2.44801958
78	DNA replication-dependent nucleosome organization (GO:0034723)	2.44457914
79	DNA replication-dependent nucleosome assembly (GO:0006335)	2.44457914
80	negative regulation of mast cell activation (GO:0033004)	2.44304855
81	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.44253937
82	isotype switching (GO:0045190)	2.44253937
83	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.44253937
84	protein K11-linked deubiquitination (GO:0035871)	2.44076651
85	behavioral response to ethanol (GO:0048149)	2.43941291
86	somite development (GO:0061053)	2.43300524
87	centrosome organization (GO:0051297)	2.43213866
88	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.42198632
89	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.42198632
90	nonmotile primary cilium assembly (GO:0035058)	2.40931504
91	cytochrome complex assembly (GO:0017004)	2.40808762
92	axoneme assembly (GO:0035082)	2.40216950
93	cell proliferation in forebrain (GO:0021846)	2.40177401
94	indole-containing compound metabolic process (GO:0042430)	2.39826576
95	microtubule organizing center organization (GO:0031023)	2.38124309
96	postreplication repair (GO:0006301)	2.37818627
97	monoubiquitinated protein deubiquitination (GO:0035520)	2.37812559
98	somite rostral/caudal axis specification (GO:0032525)	2.37567661
99	cilium organization (GO:0044782)	2.36400053
100	regulation of cilium movement (GO:0003352)	2.36156142

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.75858469
2	VDR_22108803_ChIP-Seq_LS180_Human	2.90702782
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.89538523
4	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.63532192
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.62275316
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.61663015
7	FUS_26573619_Chip-Seq_HEK293_Human	2.57284749
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.56843036
9	EWS_26573619_Chip-Seq_HEK293_Human	2.56574861
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.52577057
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.47417528
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.37208010
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.31196968
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.28036040
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.15574245
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.14951081
17	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.12512730
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.11990561
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.09687839
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.09565624
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.04844899
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.99705104
23	P300_19829295_ChIP-Seq_ESCs_Human	1.99434419
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.98699549
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.98165402
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89038514
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.88037569
28	E2F7_22180533_ChIP-Seq_HELA_Human	1.83444062
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.82287516
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.80933284
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.78357593
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.69931504
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.66688122
34	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.64113483
35	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56507572
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55103231
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.52033065
38	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.49722129
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48934136
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.48637435
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48136890
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.47786626
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.47786626
44	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47310993
45	VDR_23849224_ChIP-Seq_CD4+_Human	1.45875826
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.44196087
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.44196087
48	STAT3_23295773_ChIP-Seq_U87_Human	1.43157786
49	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.39271752
50	TCF4_23295773_ChIP-Seq_U87_Human	1.34107761
51	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.32203972
52	SMAD4_21799915_ChIP-Seq_A2780_Human	1.30986625
53	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.30581611
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27634927
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.27479177
56	AR_25329375_ChIP-Seq_VCAP_Human	1.25397284
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24238325
58	BCAT_22108803_ChIP-Seq_LS180_Human	1.23972720
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23750641
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23750641
61	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.23271409
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23222162
63	AR_21572438_ChIP-Seq_LNCaP_Human	1.21416490
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21277019
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20505460
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20492790
67	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17424337
68	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15407101
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13996088
70	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.13401929
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12357660
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11064003
73	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.10534267
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09753755
75	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09753755
76	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.09725242
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.09638490
78	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.09627066
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09105598
80	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08926858
81	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08364458
82	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.08318979
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07325828
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06283181
85	FOXP3_21729870_ChIP-Seq_TREG_Human	1.05958135
86	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.05683673
87	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.04394441
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.04141416
89	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.03499088
90	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.03164188
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02854021
92	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.01893713
93	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.00251540
94	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.99733934
95	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.99430363
96	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99335946
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98431400
98	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.98185890
99	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.97795798
100	P53_22387025_ChIP-Seq_ESCs_Mouse	0.96065885

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.75948495
2	MP0008057_abnormal_DNA_replication	3.09644932
3	MP0000569_abnormal_digit_pigmentation	2.93807054
4	MP0006292_abnormal_olfactory_placode	2.89940704
5	MP0003787_abnormal_imprinting	2.57264731
6	MP0002102_abnormal_ear_morphology	2.34362944
7	MP0003890_abnormal_embryonic-extraembry	2.29036074
8	MP0008058_abnormal_DNA_repair	2.25785122
9	MP0006072_abnormal_retinal_apoptosis	2.25752256
10	MP0003195_calcinosis	2.23199128
11	MP0010094_abnormal_chromosome_stability	2.19295840
12	MP0003880_abnormal_central_pattern	2.01853391
13	MP0005551_abnormal_eye_electrophysiolog	1.98421014
14	MP0003646_muscle_fatigue	1.90711307
15	MP0004147_increased_porphyrin_level	1.82550403
16	MP0001968_abnormal_touch/_nociception	1.75154403
17	MP0000631_abnormal_neuroendocrine_gland	1.73602535
18	MP0001485_abnormal_pinna_reflex	1.63995299
19	MP0005253_abnormal_eye_physiology	1.63792138
20	MP0008872_abnormal_physiological_respon	1.62603710
21	MP0001986_abnormal_taste_sensitivity	1.58730865
22	MP0005646_abnormal_pituitary_gland	1.57335759
23	MP0000427_abnormal_hair_cycle	1.55013329
24	MP0008995_early_reproductive_senescence	1.53259671
25	MP0003136_yellow_coat_color	1.52949170
26	MP0009046_muscle_twitch	1.52065479
27	MP0002736_abnormal_nociception_after	1.48933286
28	MP0004133_heterotaxia	1.47656453
29	MP0003121_genomic_imprinting	1.46527689
30	MP0000372_irregular_coat_pigmentation	1.45608380
31	MP0003718_maternal_effect	1.44983392
32	MP0003693_abnormal_embryo_hatching	1.42558862
33	MP0004145_abnormal_muscle_electrophysio	1.41797464
34	MP0004142_abnormal_muscle_tone	1.41543391
35	MP0002938_white_spotting	1.40993138
36	MP0005645_abnormal_hypothalamus_physiol	1.39419522
37	MP0002160_abnormal_reproductive_system	1.37397303
38	MP0001529_abnormal_vocalization	1.37148827
39	MP0002638_abnormal_pupillary_reflex	1.35944390
40	MP0004885_abnormal_endolymph	1.35937546
41	MP0002837_dystrophic_cardiac_calcinosis	1.33485666
42	MP0005174_abnormal_tail_pigmentation	1.33448506
43	MP0001293_anophthalmia	1.32915825
44	MP0002163_abnormal_gland_morphology	1.29118829
45	MP0009745_abnormal_behavioral_response	1.28869466
46	MP0003567_abnormal_fetal_cardiomyocyte	1.27508126
47	MP0006276_abnormal_autonomic_nervous	1.26149002
48	MP0005389_reproductive_system_phenotype	1.22482086
49	MP0003937_abnormal_limbs/digits/tail_de	1.21497199
50	MP0001486_abnormal_startle_reflex	1.20967262
51	MP0004742_abnormal_vestibular_system	1.19206768
52	MP0003119_abnormal_digestive_system	1.15587126
53	MP0005084_abnormal_gallbladder_morpholo	1.14654121
54	MP0002735_abnormal_chemical_nociception	1.11959061
55	MP0002095_abnormal_skin_pigmentation	1.10652552
56	MP0002928_abnormal_bile_duct	1.10005957
57	MP0002272_abnormal_nervous_system	1.09999714
58	MP0005075_abnormal_melanosome_morpholog	1.08159243
59	MP0001929_abnormal_gametogenesis	1.07193562
60	MP0002210_abnormal_sex_determination	1.06942369
61	MP0005379_endocrine/exocrine_gland_phen	1.06221099
62	MP0002751_abnormal_autonomic_nervous	1.05169974
63	MP0003011_delayed_dark_adaptation	1.04673952
64	MP0005195_abnormal_posterior_eye	0.99628269
65	MP0000383_abnormal_hair_follicle	0.99436799
66	MP0000647_abnormal_sebaceous_gland	0.98177829
67	MP0002876_abnormal_thyroid_physiology	0.97942384
68	MP0000778_abnormal_nervous_system	0.97503636
69	MP0002653_abnormal_ependyma_morphology	0.96466416
70	MP0003698_abnormal_male_reproductive	0.95936106
71	MP0001919_abnormal_reproductive_system	0.95750166
72	MP0000653_abnormal_sex_gland	0.94168732
73	MP0003077_abnormal_cell_cycle	0.94056776
74	MP0001145_abnormal_male_reproductive	0.92329161
75	MP0005386_behavior/neurological_phenoty	0.92263306
76	MP0004924_abnormal_behavior	0.92263306
77	MP0002067_abnormal_sensory_capabilities	0.89780927
78	MP0003786_premature_aging	0.88425432
79	MP0004215_abnormal_myocardial_fiber	0.86475629
80	MP0006035_abnormal_mitochondrial_morpho	0.86096773
81	MP0001286_abnormal_eye_development	0.85637853
82	MP0003111_abnormal_nucleus_morphology	0.84135644
83	MP0008875_abnormal_xenobiotic_pharmacok	0.83843030
84	MP0002557_abnormal_social/conspecific_i	0.83832329
85	MP0002234_abnormal_pharynx_morphology	0.83813806
86	MP0005391_vision/eye_phenotype	0.83709799
87	MP0001324_abnormal_eye_pigmentation	0.83252579
88	MP0004043_abnormal_pH_regulation	0.82964061
89	MP0002752_abnormal_somatic_nervous	0.80527856
90	MP0008789_abnormal_olfactory_epithelium	0.80467973
91	MP0002277_abnormal_respiratory_mucosa	0.80340713
92	MP0004957_abnormal_blastocyst_morpholog	0.80204457
93	MP0003938_abnormal_ear_development	0.79759095
94	MP0002733_abnormal_thermal_nociception	0.76854203
95	MP0001188_hyperpigmentation	0.76498881
96	MP0008007_abnormal_cellular_replicative	0.76165911
97	MP0005187_abnormal_penis_morphology	0.75864621
98	MP0001119_abnormal_female_reproductive	0.75785031
99	MP0001984_abnormal_olfaction	0.75470834
100	MP0001970_abnormal_pain_threshold	0.74645781

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.05970859
2	Pancreatic fibrosis (HP:0100732)	3.85732106
3	True hermaphroditism (HP:0010459)	3.64623518
4	Abnormality of midbrain morphology (HP:0002418)	3.44114107
5	Molar tooth sign on MRI (HP:0002419)	3.44114107
6	Nephronophthisis (HP:0000090)	3.03272589
7	Congenital stationary night blindness (HP:0007642)	2.96390270
8	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.77053504
9	Pendular nystagmus (HP:0012043)	2.71942418
10	Chromsome breakage (HP:0040012)	2.68968653
11	Chronic hepatic failure (HP:0100626)	2.67060214
12	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.66821333
13	Abnormality of chromosome stability (HP:0003220)	2.65799882
14	Abnormality of the renal medulla (HP:0100957)	2.61731927
15	Colon cancer (HP:0003003)	2.60199916
16	Hyperventilation (HP:0002883)	2.58838483
17	Abnormality of the ileum (HP:0001549)	2.58146489
18	Type II lissencephaly (HP:0007260)	2.56943024
19	Meckel diverticulum (HP:0002245)	2.55155337
20	Abolished electroretinogram (ERG) (HP:0000550)	2.52015923
21	Abnormality of the renal cortex (HP:0011035)	2.51384527
22	Genetic anticipation (HP:0003743)	2.45049467
23	Methylmalonic acidemia (HP:0002912)	2.37216300
24	Birth length less than 3rd percentile (HP:0003561)	2.37126737
25	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.33630413
26	Medial flaring of the eyebrow (HP:0010747)	2.32972413
27	Abnormality of the labia minora (HP:0012880)	2.28993163
28	Cystic liver disease (HP:0006706)	2.28143527
29	Broad-based gait (HP:0002136)	2.23469618
30	Progressive cerebellar ataxia (HP:0002073)	2.23338189
31	Attenuation of retinal blood vessels (HP:0007843)	2.18534872
32	Furrowed tongue (HP:0000221)	2.16235225
33	Protruding tongue (HP:0010808)	2.15875281
34	Sclerocornea (HP:0000647)	2.14466589
35	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.13096620
36	Anencephaly (HP:0002323)	2.12491272
37	Gaze-evoked nystagmus (HP:0000640)	2.11610062
38	Patellar aplasia (HP:0006443)	2.09341327
39	Sloping forehead (HP:0000340)	2.08786114
40	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.08202894
41	Renal cortical cysts (HP:0000803)	2.08103389
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.07010809
43	Volvulus (HP:0002580)	2.04098079
44	Lissencephaly (HP:0001339)	2.03170741
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.02885851
46	Abnormality of alanine metabolism (HP:0010916)	2.02885851
47	Hyperalaninemia (HP:0003348)	2.02885851
48	Clubbing of toes (HP:0100760)	2.02504280
49	Inability to walk (HP:0002540)	2.02385264
50	Intestinal atresia (HP:0011100)	2.02176278
51	Stomach cancer (HP:0012126)	2.01320492
52	Congenital, generalized hypertrichosis (HP:0004540)	2.01263719
53	Decreased central vision (HP:0007663)	2.00514035
54	Aplasia/Hypoplasia of the patella (HP:0006498)	1.99074647
55	Abnormal biliary tract physiology (HP:0012439)	1.97777322
56	Bile duct proliferation (HP:0001408)	1.97777322
57	Acute necrotizing encephalopathy (HP:0006965)	1.95555506
58	Methylmalonic aciduria (HP:0012120)	1.94964659
59	Male pseudohermaphroditism (HP:0000037)	1.94824922
60	Abnormality of the preputium (HP:0100587)	1.94754241
61	3-Methylglutaconic aciduria (HP:0003535)	1.92996561
62	Progressive inability to walk (HP:0002505)	1.91156948
63	Large for gestational age (HP:0001520)	1.91006120
64	Septo-optic dysplasia (HP:0100842)	1.90848318
65	Genital tract atresia (HP:0001827)	1.89952192
66	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.89182501
67	Optic nerve hypoplasia (HP:0000609)	1.87895812
68	Progressive macrocephaly (HP:0004481)	1.87437687
69	Increased CSF lactate (HP:0002490)	1.86820923
70	Dandy-Walker malformation (HP:0001305)	1.85314861
71	Gait imbalance (HP:0002141)	1.84754291
72	Congenital hepatic fibrosis (HP:0002612)	1.84288803
73	Congenital primary aphakia (HP:0007707)	1.83916562
74	Small intestinal stenosis (HP:0012848)	1.83781657
75	Duodenal stenosis (HP:0100867)	1.83781657
76	Abnormality of the pons (HP:0007361)	1.83287218
77	Chorioretinal atrophy (HP:0000533)	1.82929218
78	Acute encephalopathy (HP:0006846)	1.82330391
79	Tubular atrophy (HP:0000092)	1.81673175
80	Neoplasm of the adrenal cortex (HP:0100641)	1.80587320
81	Mitochondrial inheritance (HP:0001427)	1.80219587
82	Vaginal atresia (HP:0000148)	1.79828512
83	Hyperglycinemia (HP:0002154)	1.79075212
84	Supernumerary spleens (HP:0009799)	1.78582404
85	Hypoplasia of the pons (HP:0012110)	1.78399705
86	Cerebellar dysplasia (HP:0007033)	1.77961674
87	Abnormality of the renal collecting system (HP:0004742)	1.77711805
88	Postaxial foot polydactyly (HP:0001830)	1.77211988
89	Nephrogenic diabetes insipidus (HP:0009806)	1.75636738
90	Hypothermia (HP:0002045)	1.75413945
91	Lipid accumulation in hepatocytes (HP:0006561)	1.74175387
92	Small hand (HP:0200055)	1.73822699
93	Abnormality of the duodenum (HP:0002246)	1.73113551
94	Oligodactyly (hands) (HP:0001180)	1.69398692
95	Increased hepatocellular lipid droplets (HP:0006565)	1.69393738
96	Aplasia/hypoplasia of the uterus (HP:0008684)	1.69211924
97	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.68980642
98	Thyroid-stimulating hormone excess (HP:0002925)	1.68869484
99	Abnormality of the carotid arteries (HP:0005344)	1.68200839
100	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.67917654

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.55063648
2	BMPR1B	3.02640220
3	ZAK	2.79852342
4	NUAK1	2.73447575
5	ACVR1B	2.72971262
6	WNK3	2.66944072
7	ADRBK2	2.56686242
8	TNIK	2.18238373
9	MKNK2	2.18078639
10	MAP4K2	2.03232067
11	BRSK2	1.92712522
12	PLK4	1.86569570
13	CDC7	1.85022445
14	GRK1	1.82862606
15	TLK1	1.80024271
16	PNCK	1.72626055
17	TRIM28	1.70482251
18	WEE1	1.66710979
19	CASK	1.65899593
20	TAOK3	1.54552190
21	MKNK1	1.53156402
22	INSRR	1.51465966
23	VRK1	1.51014171
24	PINK1	1.47631518
25	MAPK13	1.47505027
26	TAF1	1.43437913
27	SRPK1	1.33709284
28	PLK3	1.28384434
29	MAP3K4	1.27424247
30	TGFBR1	1.26369150
31	WNK4	1.21447548
32	MST4	1.19153497
33	OXSR1	1.18759466
34	DYRK2	1.12364943
35	CAMKK2	1.11573571
36	EIF2AK3	1.10588047
37	BUB1	0.96303850
38	STK39	0.95731745
39	ERBB3	0.93581213
40	DYRK3	0.93498355
41	TTK	0.93442361
42	TEC	0.93130452
43	STK16	0.91716818
44	STK38L	0.91002533
45	VRK2	0.89660412
46	PLK1	0.88458626
47	PLK2	0.88100937
48	TXK	0.86177975
49	TSSK6	0.84177978
50	FGFR2	0.81427124
51	STK3	0.81034630
52	ATR	0.80752163
53	CHEK2	0.78941260
54	NEK2	0.78091347
55	ADRBK1	0.74739531
56	CSNK1G2	0.74274084
57	NEK1	0.72670201
58	CSNK1G1	0.71703432
59	PASK	0.70381289
60	BRD4	0.70067579
61	NTRK3	0.69442917
62	PAK3	0.68641668
63	NLK	0.67970538
64	PRKCG	0.66543548
65	BCR	0.65093126
66	PRKCE	0.63366662
67	ATM	0.62768271
68	EIF2AK2	0.60572813
69	CCNB1	0.59525128
70	CSNK1G3	0.59227574
71	CDK3	0.58620574
72	IRAK1	0.57070241
73	RPS6KA5	0.57012253
74	PIK3CA	0.56999641
75	MARK1	0.55858225
76	TIE1	0.55777492
77	CSNK1A1L	0.53534297
78	STK11	0.50523070
79	LATS1	0.43211943
80	MAP2K7	0.41597169
81	DAPK2	0.41481037
82	CLK1	0.41432840
83	NTRK2	0.41262202
84	RPS6KA4	0.40626612
85	MAPKAPK5	0.39196412
86	CSNK1D	0.38959454
87	CDK19	0.37780562
88	PRKCQ	0.37498426
89	DYRK1A	0.35702754
90	AURKB	0.35386454
91	IKBKB	0.35247727
92	ERBB2	0.34813074
93	CSNK1A1	0.34572060
94	NME1	0.32642841
95	OBSCN	0.31573793
96	PKN1	0.31198599
97	ITK	0.30539712
98	CAMK1G	0.29814707
99	AKT3	0.29434692
100	CAMK2A	0.28925063

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	3.19914526
2	Fanconi anemia pathway_Homo sapiens_hsa03460	2.86852412
3	Phototransduction_Homo sapiens_hsa04744	2.63118505
4	Basal transcription factors_Homo sapiens_hsa03022	2.35222651
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.31439506
6	RNA polymerase_Homo sapiens_hsa03020	2.30826836
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.19319343
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.16162660
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.13267186
10	RNA degradation_Homo sapiens_hsa03018	2.11110531
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.08497806
12	Protein export_Homo sapiens_hsa03060	2.08207363
13	Non-homologous end-joining_Homo sapiens_hsa03450	2.07135484
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.03256700
15	Mismatch repair_Homo sapiens_hsa03430	1.96001578
16	Nicotine addiction_Homo sapiens_hsa05033	1.93534788
17	Butanoate metabolism_Homo sapiens_hsa00650	1.90713842
18	Parkinsons disease_Homo sapiens_hsa05012	1.81137454
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.77179594
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.76126864
21	One carbon pool by folate_Homo sapiens_hsa00670	1.71923106
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.70479823
23	DNA replication_Homo sapiens_hsa03030	1.69331364
24	Caffeine metabolism_Homo sapiens_hsa00232	1.67985752
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.65728076
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.64420839
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.59900506
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.58442102
29	Propanoate metabolism_Homo sapiens_hsa00640	1.53305517
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.47919639
31	RNA transport_Homo sapiens_hsa03013	1.47815726
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.42078355
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.41037166
34	Olfactory transduction_Homo sapiens_hsa04740	1.40583658
35	Taste transduction_Homo sapiens_hsa04742	1.34358583
36	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.32231470
37	Huntingtons disease_Homo sapiens_hsa05016	1.29471628
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.26441014
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24889713
40	Base excision repair_Homo sapiens_hsa03410	1.12233173
41	Ribosome_Homo sapiens_hsa03010	1.10784087
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.10679176
43	Spliceosome_Homo sapiens_hsa03040	1.10149906
44	Purine metabolism_Homo sapiens_hsa00230	1.04378757
45	Peroxisome_Homo sapiens_hsa04146	0.98437369
46	Morphine addiction_Homo sapiens_hsa05032	0.95605996
47	Cell cycle_Homo sapiens_hsa04110	0.94439856
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.93939165
49	Alzheimers disease_Homo sapiens_hsa05010	0.93148526
50	Regulation of autophagy_Homo sapiens_hsa04140	0.92708911
51	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.92360151
52	Steroid biosynthesis_Homo sapiens_hsa00100	0.91371970
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.90241519
54	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.90106369
55	Proteasome_Homo sapiens_hsa03050	0.85934390
56	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.84830968
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.80795768
58	Primary immunodeficiency_Homo sapiens_hsa05340	0.78993869
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.77209095
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69460575
61	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.69354066
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68422308
63	Serotonergic synapse_Homo sapiens_hsa04726	0.68105585
64	Glutamatergic synapse_Homo sapiens_hsa04724	0.67533923
65	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.66521666
66	ABC transporters_Homo sapiens_hsa02010	0.63929447
67	p53 signaling pathway_Homo sapiens_hsa04115	0.63227003
68	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.60431310
69	Retinol metabolism_Homo sapiens_hsa00830	0.58360784
70	mRNA surveillance pathway_Homo sapiens_hsa03015	0.56341149
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55356231
72	Circadian entrainment_Homo sapiens_hsa04713	0.55322492
73	Metabolic pathways_Homo sapiens_hsa01100	0.55055569
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.55049733
75	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.54846602
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.52867962
77	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.52252297
78	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.51386065
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.51134232
80	Alcoholism_Homo sapiens_hsa05034	0.50759261
81	GABAergic synapse_Homo sapiens_hsa04727	0.49076281
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47619164
83	Circadian rhythm_Homo sapiens_hsa04710	0.46127206
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45594125
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42526392
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42234991
87	Sulfur metabolism_Homo sapiens_hsa00920	0.41328567
88	Long-term depression_Homo sapiens_hsa04730	0.40658000
89	Insulin secretion_Homo sapiens_hsa04911	0.40552689
90	Asthma_Homo sapiens_hsa05310	0.38579047
91	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.37945355
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37514784
93	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.35816502
94	Lysine degradation_Homo sapiens_hsa00310	0.35530072
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.35270892
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.34962285
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.34412443
98	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.32949650
99	Basal cell carcinoma_Homo sapiens_hsa05217	0.32521810
100	Dopaminergic synapse_Homo sapiens_hsa04728	0.31227853

ZNF100

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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