ZNF101

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc finger proteins (ZNFs), such as ZNF101, bind nucleic acids and perform many key functions, the most important of which is regulating transcription (summary by Bellefroid et al., 1993 [PubMed 8467795]). See ZNF91 (MIM 603971) for general information on ZNFs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)4.74117983
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.68626962
3negative thymic T cell selection (GO:0045060)4.27738308
4positive regulation of gamma-delta T cell activation (GO:0046645)4.25762826
5DNA deamination (GO:0045006)4.24419263
6regulation of B cell receptor signaling pathway (GO:0050855)4.22896124
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.81947915
8negative regulation of cell killing (GO:0031342)3.81947915
9regulation of gamma-delta T cell differentiation (GO:0045586)3.81872878
10behavioral response to nicotine (GO:0035095)3.64344507
11cellular response to interleukin-15 (GO:0071350)3.62121639
12positive T cell selection (GO:0043368)3.59689021
13regulation of gamma-delta T cell activation (GO:0046643)3.53537201
14activated T cell proliferation (GO:0050798)3.48297025
15tolerance induction (GO:0002507)3.45124834
16fucose catabolic process (GO:0019317)3.44249487
17L-fucose metabolic process (GO:0042354)3.44249487
18L-fucose catabolic process (GO:0042355)3.44249487
19interferon-gamma production (GO:0032609)3.36618976
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.34829444
21response to interleukin-15 (GO:0070672)3.34424780
22negative regulation of telomere maintenance (GO:0032205)3.28494410
23negative regulation of translation, ncRNA-mediated (GO:0040033)3.21926784
24regulation of translation, ncRNA-mediated (GO:0045974)3.21926784
25negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.21926784
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.20208879
27positive regulation of granulocyte differentiation (GO:0030854)3.18126978
28regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.16505306
29regulation of posttranscriptional gene silencing (GO:0060147)3.14287940
30regulation of gene silencing by miRNA (GO:0060964)3.14287940
31regulation of gene silencing by RNA (GO:0060966)3.14287940
32T cell selection (GO:0045058)3.14077613
33positive regulation of defense response to virus by host (GO:0002230)3.13519051
34regulation of regulatory T cell differentiation (GO:0045589)3.06384128
35regulation of alpha-beta T cell proliferation (GO:0046640)3.02530948
36positive regulation of alpha-beta T cell proliferation (GO:0046641)3.01413919
37mast cell degranulation (GO:0043303)3.00551625
38mast cell activation involved in immune response (GO:0002279)3.00551625
39mast cell activation (GO:0045576)2.99726380
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98912053
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98912053
42negative regulation of T cell mediated immunity (GO:0002710)2.98602036
43tryptophan catabolic process (GO:0006569)2.97088671
44indole-containing compound catabolic process (GO:0042436)2.97088671
45indolalkylamine catabolic process (GO:0046218)2.97088671
46regulation of T cell mediated cytotoxicity (GO:0001914)2.97031121
47indolalkylamine metabolic process (GO:0006586)2.95188814
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.93726378
49neural tube formation (GO:0001841)2.92409547
50regulation of nuclear cell cycle DNA replication (GO:0033262)2.91462216
51regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.91083061
52positive regulation of T cell mediated cytotoxicity (GO:0001916)2.90268766
53positive thymic T cell selection (GO:0045059)2.89605289
54regulation of B cell differentiation (GO:0045577)2.88593489
55regulation of isotype switching to IgG isotypes (GO:0048302)2.82426221
56cytidine deamination (GO:0009972)2.82194128
57cytidine metabolic process (GO:0046087)2.82194128
58cytidine catabolic process (GO:0006216)2.82194128
59protein K11-linked deubiquitination (GO:0035871)2.81576678
60kynurenine metabolic process (GO:0070189)2.79889955
61thymic T cell selection (GO:0045061)2.75775607
62RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.74947646
63antigen processing and presentation of endogenous antigen (GO:0019883)2.72474432
64regulation of T cell receptor signaling pathway (GO:0050856)2.70516435
65tryptophan metabolic process (GO:0006568)2.69176499
66pyrimidine ribonucleoside catabolic process (GO:0046133)2.65280273
67rRNA catabolic process (GO:0016075)2.65037150
68antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.65008390
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63749943
70negative regulation by host of viral transcription (GO:0043922)2.63599884
71adenosine metabolic process (GO:0046085)2.63193875
72pseudouridine synthesis (GO:0001522)2.63005670
73positive regulation of T cell differentiation in thymus (GO:0033089)2.61535181
74B cell receptor signaling pathway (GO:0050853)2.61309934
75T cell migration (GO:0072678)2.61028803
76positive regulation of mRNA catabolic process (GO:0061014)2.59222526
77regulation of memory T cell differentiation (GO:0043380)2.58290066
78regulation of leukocyte mediated cytotoxicity (GO:0001910)2.58023955
79positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.56383277
80negative regulation of lymphocyte mediated immunity (GO:0002707)2.53998603
81antigen receptor-mediated signaling pathway (GO:0050851)2.53657999
82positive regulation of B cell differentiation (GO:0045579)2.52378348
83alpha-beta T cell differentiation (GO:0046632)2.51021237
84DNA demethylation (GO:0080111)2.50820158
85regulation of defense response to virus by host (GO:0050691)2.48932500
86negative regulation of interleukin-1 beta production (GO:0032691)2.47380104
87sulfation (GO:0051923)2.45663863
88regulation of telomere maintenance (GO:0032204)2.44339834
89respiratory chain complex IV assembly (GO:0008535)2.43234025
90regulation of cell killing (GO:0031341)2.42195440
91protein K63-linked deubiquitination (GO:0070536)2.42166710
92preassembly of GPI anchor in ER membrane (GO:0016254)2.41648620
93hepatocyte apoptotic process (GO:0097284)2.41517678
94regulation of MHC class I biosynthetic process (GO:0045343)2.41017233
95T cell receptor signaling pathway (GO:0050852)2.40616339
96tRNA modification (GO:0006400)2.40533389
97negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.40415922
98double-strand break repair via homologous recombination (GO:0000724)2.39951737
99reciprocal DNA recombination (GO:0035825)2.39901379
100reciprocal meiotic recombination (GO:0007131)2.39901379

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.49706161
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.97890546
3ZNF274_21170338_ChIP-Seq_K562_Hela3.63932685
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.33120547
5NOTCH1_21737748_ChIP-Seq_TLL_Human3.19337382
6VDR_22108803_ChIP-Seq_LS180_Human2.73941306
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.49467034
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37987106
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.33676826
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.27220619
11RUNX_20019798_ChIP-Seq_JUKART_Human2.17277487
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.14657186
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09373595
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07080292
15* MYB_26560356_Chip-Seq_TH2_Human2.06096690
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98549186
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97042259
18VDR_23849224_ChIP-Seq_CD4+_Human1.89514766
19GABP_17652178_ChIP-ChIP_JURKAT_Human1.89276725
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85428133
21GATA3_26560356_Chip-Seq_TH2_Human1.82621745
22EWS_26573619_Chip-Seq_HEK293_Human1.81022095
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67432317
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.67357929
25GATA3_27048872_Chip-Seq_THYMUS_Human1.64443274
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.63343414
27ER_23166858_ChIP-Seq_MCF-7_Human1.62350254
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60049041
29IRF1_19129219_ChIP-ChIP_H3396_Human1.54926119
30GBX2_23144817_ChIP-Seq_PC3_Human1.52711892
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52585267
32MYB_26560356_Chip-Seq_TH1_Human1.51232814
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.49239976
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48766256
35TP53_22573176_ChIP-Seq_HFKS_Human1.46299926
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45375260
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43123597
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42516273
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42482027
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39226395
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39106632
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38308795
43FUS_26573619_Chip-Seq_HEK293_Human1.38003592
44MYC_18940864_ChIP-ChIP_HL60_Human1.35797922
45IGF1R_20145208_ChIP-Seq_DFB_Human1.35317982
46BCAT_22108803_ChIP-Seq_LS180_Human1.33137726
47P300_19829295_ChIP-Seq_ESCs_Human1.31038035
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27790802
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23201753
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21651467
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20654336
52ELK1_19687146_ChIP-ChIP_HELA_Human1.20176984
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.19970078
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19970078
55PRDM14_20953172_ChIP-Seq_ESCs_Human1.19618510
56TAF15_26573619_Chip-Seq_HEK293_Human1.18630855
57STAT3_23295773_ChIP-Seq_U87_Human1.16740531
58GATA3_26560356_Chip-Seq_TH1_Human1.16540905
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15819857
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15074102
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14948481
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14831793
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.13825538
64HOXB7_26014856_ChIP-Seq_BT474_Human1.13644707
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13203203
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.12268764
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11590563
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11008036
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09434864
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08918630
71CBP_20019798_ChIP-Seq_JUKART_Human1.08918630
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07280651
73SCL_19346495_ChIP-Seq_HPC-7_Human1.07259642
74SMRT_27268052_Chip-Seq_Bcells_Human1.06845155
75TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06724645
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05869319
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05102348
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.04522876
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04228241
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04228241
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02590749
82TCF4_23295773_ChIP-Seq_U87_Human1.02389165
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.02375662
84AR_20517297_ChIP-Seq_VCAP_Human1.01980810
85SOX2_19829295_ChIP-Seq_ESCs_Human1.01705105
86NANOG_19829295_ChIP-Seq_ESCs_Human1.01705105
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01333237
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00614313
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99810315
90* NCOR_22424771_ChIP-Seq_293T_Human0.98448258
91SPI1_23547873_ChIP-Seq_NB4_Human0.97365598
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.96803006
93* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96385905
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95926787
95TCF4_22108803_ChIP-Seq_LS180_Human0.95616910
96RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94651969
97GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94330756
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93239079
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92678178
100EZH2_22144423_ChIP-Seq_EOC_Human0.91803242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.38782272
2MP0003763_abnormal_thymus_physiology3.15956387
3MP0008877_abnormal_DNA_methylation2.93552009
4MP0001800_abnormal_humoral_immune2.81911992
5MP0001835_abnormal_antigen_presentation2.60215773
6MP0003724_increased_susceptibility_to2.23237619
7MP0008057_abnormal_DNA_replication2.18403676
8MP0003195_calcinosis2.15706919
9MP0000685_abnormal_immune_system2.13556900
10MP0000569_abnormal_digit_pigmentation2.11047829
11MP0003646_muscle_fatigue2.08851682
12MP0002723_abnormal_immune_serum2.07676262
13MP0005387_immune_system_phenotype2.07220414
14MP0001790_abnormal_immune_system2.07220414
15MP0002138_abnormal_hepatobiliary_system2.01731680
16MP0005000_abnormal_immune_tolerance1.97035664
17MP0002452_abnormal_antigen_presenting1.96173785
18MP0002420_abnormal_adaptive_immunity1.94878005
19MP0001819_abnormal_immune_cell1.92790867
20MP0005075_abnormal_melanosome_morpholog1.90925170
21MP0009333_abnormal_splenocyte_physiolog1.89294103
22MP0001873_stomach_inflammation1.83762084
23MP0001986_abnormal_taste_sensitivity1.76607126
24MP0002398_abnormal_bone_marrow1.72642046
25MP0000703_abnormal_thymus_morphology1.70171888
26MP0000689_abnormal_spleen_morphology1.69648062
27MP0009785_altered_susceptibility_to1.68920662
28MP0003787_abnormal_imprinting1.68106269
29MP0005310_abnormal_salivary_gland1.67605229
30MP0008995_early_reproductive_senescence1.66431780
31MP0000716_abnormal_immune_system1.63233553
32MP0002148_abnormal_hypersensitivity_rea1.61932952
33MP0008872_abnormal_physiological_respon1.61475281
34MP0004381_abnormal_hair_follicle1.61328009
35MP0002396_abnormal_hematopoietic_system1.57191476
36MP0002163_abnormal_gland_morphology1.55615913
37MP0002254_reproductive_system_inflammat1.54752912
38MP0002277_abnormal_respiratory_mucosa1.46805300
39MP0005551_abnormal_eye_electrophysiolog1.44957786
40MP0002405_respiratory_system_inflammati1.42072668
41MP0005025_abnormal_response_to1.41682489
42MP0004043_abnormal_pH_regulation1.40558048
43MP0002722_abnormal_immune_system1.40356388
44MP0002102_abnormal_ear_morphology1.38468779
45MP0005174_abnormal_tail_pigmentation1.38301356
46MP0008058_abnormal_DNA_repair1.38267437
47MP0001919_abnormal_reproductive_system1.36687640
48MP0001968_abnormal_touch/_nociception1.34052929
49MP0004130_abnormal_muscle_cell1.27657732
50MP0003436_decreased_susceptibility_to1.25354608
51MP0002429_abnormal_blood_cell1.24650544
52MP0005645_abnormal_hypothalamus_physiol1.24594726
53MP0003866_abnormal_defecation1.24460630
54MP0006292_abnormal_olfactory_placode1.22529877
55MP0000427_abnormal_hair_cycle1.17835799
56MP0002419_abnormal_innate_immunity1.17791249
57MP0004142_abnormal_muscle_tone1.17038826
58MP0002009_preneoplasia1.15370153
59MP0005389_reproductive_system_phenotype1.14901217
60MP0003136_yellow_coat_color1.13520096
61MP0004133_heterotaxia1.11546506
62MP0000372_irregular_coat_pigmentation1.07898597
63MP0009764_decreased_sensitivity_to1.07147803
64MP0001845_abnormal_inflammatory_respons1.04976823
65MP0001485_abnormal_pinna_reflex1.04939690
66MP0002837_dystrophic_cardiac_calcinosis1.04662407
67MP0002095_abnormal_skin_pigmentation1.03455938
68MP0003693_abnormal_embryo_hatching1.02628853
69MP0010155_abnormal_intestine_physiology1.02276480
70MP0002736_abnormal_nociception_after1.01404763
71MP0002876_abnormal_thyroid_physiology1.00752482
72MP0002166_altered_tumor_susceptibility0.99868882
73MP0002693_abnormal_pancreas_physiology0.99234568
74MP0005646_abnormal_pituitary_gland0.97375996
75MP0003786_premature_aging0.96045855
76MP0010094_abnormal_chromosome_stability0.95513750
77MP0005379_endocrine/exocrine_gland_phen0.94381550
78MP0001501_abnormal_sleep_pattern0.93766410
79MP0000015_abnormal_ear_pigmentation0.90957188
80MP0002928_abnormal_bile_duct0.89320319
81MP0002006_tumorigenesis0.87266253
82MP0000470_abnormal_stomach_morphology0.84876538
83MP0004147_increased_porphyrin_level0.84331243
84MP0005253_abnormal_eye_physiology0.83625100
85MP0002653_abnormal_ependyma_morphology0.81751149
86MP0006072_abnormal_retinal_apoptosis0.81291593
87MP0000631_abnormal_neuroendocrine_gland0.80691689
88MP0003890_abnormal_embryonic-extraembry0.79669948
89MP0008875_abnormal_xenobiotic_pharmacok0.79527133
90MP0008961_abnormal_basal_metabolism0.79183127
91MP0003183_abnormal_peptide_metabolism0.78799840
92MP0006082_CNS_inflammation0.76717502
93MP0009745_abnormal_behavioral_response0.76022329
94MP0001764_abnormal_homeostasis0.75471936
95MP0002933_joint_inflammation0.75423841
96MP0003806_abnormal_nucleotide_metabolis0.74655231
97MP0003252_abnormal_bile_duct0.73521630
98MP0005084_abnormal_gallbladder_morpholo0.70419416
99MP0002019_abnormal_tumor_incidence0.69890930
100MP0002160_abnormal_reproductive_system0.69728261

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.65340708
2T lymphocytopenia (HP:0005403)3.46413445
3Abnormality of T cell number (HP:0011839)3.38726774
4Stomatitis (HP:0010280)3.36666514
5Abnormality of alanine metabolism (HP:0010916)3.34110050
6Hyperalaninemia (HP:0003348)3.34110050
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.34110050
8Congenital stationary night blindness (HP:0007642)3.18395005
9Panhypogammaglobulinemia (HP:0003139)3.13467565
10IgG deficiency (HP:0004315)3.11479603
11Pancreatic fibrosis (HP:0100732)3.05240868
12Elevated erythrocyte sedimentation rate (HP:0003565)3.04047931
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.03431173
14Stomach cancer (HP:0012126)2.97698147
15Abnormality of T cells (HP:0002843)2.83723092
16Attenuation of retinal blood vessels (HP:0007843)2.79847819
17Severe combined immunodeficiency (HP:0004430)2.79686728
18True hermaphroditism (HP:0010459)2.75330633
19Molar tooth sign on MRI (HP:0002419)2.71903844
20Abnormality of midbrain morphology (HP:0002418)2.71903844
21Chronic hepatic failure (HP:0100626)2.64227074
22Progressive inability to walk (HP:0002505)2.59111836
23Abolished electroretinogram (ERG) (HP:0000550)2.57807618
24Abnormality of the renal cortex (HP:0011035)2.53515394
25Thyroiditis (HP:0100646)2.50913536
26Recurrent fungal infections (HP:0002841)2.47234001
27Birth length less than 3rd percentile (HP:0003561)2.46069523
28Retrobulbar optic neuritis (HP:0100654)2.45663914
29Optic neuritis (HP:0100653)2.45663914
30Genetic anticipation (HP:0003743)2.41797505
31Nephronophthisis (HP:0000090)2.38095195
32Chronic otitis media (HP:0000389)2.35590830
33Myositis (HP:0100614)2.33550846
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.30573710
35Recurrent cutaneous fungal infections (HP:0011370)2.28712775
36Chronic mucocutaneous candidiasis (HP:0002728)2.28712775
37Encephalitis (HP:0002383)2.28095993
38Abnormality of eosinophils (HP:0001879)2.26263010
39Inability to walk (HP:0002540)2.23141334
40Constricted visual fields (HP:0001133)2.22581448
41Pustule (HP:0200039)2.22505087
42Abnormality of B cell number (HP:0010975)2.22252091
43Abnormality of T cell physiology (HP:0011840)2.21469440
44Pendular nystagmus (HP:0012043)2.21265309
45Clumsiness (HP:0002312)2.20342761
46Abnormality of homocysteine metabolism (HP:0010919)2.16046670
47Homocystinuria (HP:0002156)2.16046670
48Congenital sensorineural hearing impairment (HP:0008527)2.15101263
49Abnormality of the renal medulla (HP:0100957)2.13706309
50Gaze-evoked nystagmus (HP:0000640)2.12229544
51Combined immunodeficiency (HP:0005387)2.12177289
52Protruding tongue (HP:0010808)2.11519016
53Abnormality of the pons (HP:0007361)2.08703321
54Progressive cerebellar ataxia (HP:0002073)2.06194862
55Autoimmune hemolytic anemia (HP:0001890)2.01490267
56Hyperventilation (HP:0002883)2.00635175
57Aplasia/Hypoplasia of the uvula (HP:0010293)1.99456044
58Abnormality of chromosome stability (HP:0003220)1.99307254
59Orchitis (HP:0100796)1.98327741
60Abnormal biliary tract physiology (HP:0012439)1.96385900
61Bile duct proliferation (HP:0001408)1.96385900
62Abnormal rod and cone electroretinograms (HP:0008323)1.95589517
63Colon cancer (HP:0003003)1.94521145
64Clubbing of toes (HP:0100760)1.93598796
65Lymphopenia (HP:0001888)1.92318231
66Keratoconjunctivitis (HP:0001096)1.91814333
67Abnormality of the renal collecting system (HP:0004742)1.91049967
68Anorexia (HP:0002039)1.88880854
69Abnormality of the prostate (HP:0008775)1.88591300
70Duplicated collecting system (HP:0000081)1.87883708
71Hemoptysis (HP:0002105)1.87084757
72Renal cortical cysts (HP:0000803)1.86539419
73Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85847896
74Polydipsia (HP:0001959)1.85592554
75Abnormal drinking behavior (HP:0030082)1.85592554
76Cystic liver disease (HP:0006706)1.85318014
77Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85172732
78Vasculitis (HP:0002633)1.82978142
79Abnormality of the ileum (HP:0001549)1.80613511
80Abnormality of DNA repair (HP:0003254)1.80597777
81Chronic diarrhea (HP:0002028)1.80170380
82Meningitis (HP:0001287)1.79299902
83Aplasia/Hypoplasia of the spleen (HP:0010451)1.79006846
84Asplenia (HP:0001746)1.78748957
85Large for gestational age (HP:0001520)1.78616512
86Decreased circulating renin level (HP:0003351)1.78427165
87Chromsome breakage (HP:0040012)1.78201214
88Leukocytosis (HP:0001974)1.78096431
89Hypoplasia of the pons (HP:0012110)1.77831839
90IgM deficiency (HP:0002850)1.77726532
91Eosinophilia (HP:0001880)1.77405989
92Prostate neoplasm (HP:0100787)1.77390397
93Agammaglobulinemia (HP:0004432)1.76602168
94Spontaneous hematomas (HP:0007420)1.76498171
95Recurrent viral infections (HP:0004429)1.76170423
96Meckel diverticulum (HP:0002245)1.75343127
97Medial flaring of the eyebrow (HP:0010747)1.75305313
98Keratoconjunctivitis sicca (HP:0001097)1.75234224
99Recurrent bronchitis (HP:0002837)1.74696949
100Tubular atrophy (HP:0000092)1.74436533

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.08573726
2TXK4.06593675
3ACVR1B3.37494250
4MAP4K13.12685483
5TLK12.91126763
6ZAK2.52320881
7NUAK12.45038845
8BMPR1B2.44567414
9TAOK32.39759223
10ADRBK22.37971925
11IKBKE1.87568265
12NLK1.79391922
13TEC1.77381511
14ITK1.75553525
15CAMKK21.70406629
16PASK1.52870904
17WNK41.49055770
18SYK1.47545765
19JAK31.46867644
20WNK31.46826992
21GRK11.44826221
22GRK61.38688063
23BTK1.34778133
24IKBKB1.28620415
25MAP2K61.27505069
26RIPK41.27475754
27PRKCQ1.25798710
28MAP4K21.23860908
29BLK1.21156489
30LCK1.18685396
31IRAK41.15328238
32MKNK21.13944088
33TNK21.12186168
34PINK11.11225741
35MST41.09566057
36FES1.05388017
37TAF11.03690095
38OXSR11.01244137
39INSRR0.96345470
40LYN0.96279542
41SIK20.92325790
42ADRBK10.89397495
43MAP3K140.87849854
44BRSK20.87396063
45PIM10.86335127
46MAPK130.85843043
47MARK30.83958808
48IRAK10.82811894
49FGFR20.79815854
50VRK10.79775198
51TNIK0.77782763
52ZAP700.74616943
53TGFBR10.73605581
54CAMKK10.71954791
55HCK0.71135013
56KIT0.69801914
57STK110.68499602
58STK390.67303978
59MELK0.67222206
60CSK0.64946319
61JAK10.64066301
62TYK20.63344548
63FGR0.61126786
64CHUK0.58398204
65ATR0.57489777
66TRIM280.55723378
67RPS6KA50.52405631
68HIPK20.50765523
69VRK20.50201945
70SGK20.49255801
71PIK3CA0.48487071
72PAK30.47733196
73MAPKAPK30.46416243
74DAPK20.46009775
75STK160.40497642
76CSF1R0.38971212
77STK40.38375807
78RPS6KA60.36976189
79PIK3CG0.36534696
80MAP3K40.35812438
81PLK40.35800391
82YES10.34404929
83MAPK110.34220183
84DYRK20.34143341
85JAK20.34138601
86CDK40.33794444
87CAMK10.32746059
88MAP3K70.32628726
89STK30.31457744
90PTK2B0.31442823
91NTRK20.31392257
92GRK70.31322109
93KDR0.30954259
94CDK190.30499368
95BRD40.29811857
96RPS6KB20.29159356
97WNK10.29056405
98FGFR30.28851318
99EIF2AK30.28349640
100CHEK20.27472890

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.03097173
2Graft-versus-host disease_Homo sapiens_hsa053322.69817226
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.55552722
4Allograft rejection_Homo sapiens_hsa053302.54658078
5Autoimmune thyroid disease_Homo sapiens_hsa053202.53550349
6Homologous recombination_Homo sapiens_hsa034402.15805360
7Selenocompound metabolism_Homo sapiens_hsa004502.14919021
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07912247
9Type I diabetes mellitus_Homo sapiens_hsa049402.07681522
10T cell receptor signaling pathway_Homo sapiens_hsa046601.93435475
11Phototransduction_Homo sapiens_hsa047441.91072501
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.89520234
13Linoleic acid metabolism_Homo sapiens_hsa005911.86963902
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84741554
15Fanconi anemia pathway_Homo sapiens_hsa034601.81464492
16RNA polymerase_Homo sapiens_hsa030201.81253518
17Asthma_Homo sapiens_hsa053101.77558483
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72625913
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.70459673
20Nitrogen metabolism_Homo sapiens_hsa009101.68081723
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.67616482
22Hematopoietic cell lineage_Homo sapiens_hsa046401.54651025
23RNA degradation_Homo sapiens_hsa030181.53574570
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.51124677
25Antigen processing and presentation_Homo sapiens_hsa046121.50948560
26Basal transcription factors_Homo sapiens_hsa030221.50887135
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48646906
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47241648
29One carbon pool by folate_Homo sapiens_hsa006701.46225713
30Measles_Homo sapiens_hsa051621.39340851
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35548472
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35479263
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28617561
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28481098
35Regulation of autophagy_Homo sapiens_hsa041401.25154553
36Ether lipid metabolism_Homo sapiens_hsa005651.21374073
37Non-homologous end-joining_Homo sapiens_hsa034501.19552729
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.17862119
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.12607019
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11584164
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09602272
42Caffeine metabolism_Homo sapiens_hsa002321.07842334
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05317321
44Herpes simplex infection_Homo sapiens_hsa051681.02195502
45B cell receptor signaling pathway_Homo sapiens_hsa046620.98160804
46Olfactory transduction_Homo sapiens_hsa047400.93392337
47Morphine addiction_Homo sapiens_hsa050320.89234607
48Butanoate metabolism_Homo sapiens_hsa006500.88015913
49Staphylococcus aureus infection_Homo sapiens_hsa051500.84035997
50Taste transduction_Homo sapiens_hsa047420.83646619
51Vitamin digestion and absorption_Homo sapiens_hsa049770.83333067
52ABC transporters_Homo sapiens_hsa020100.80983676
53Rheumatoid arthritis_Homo sapiens_hsa053230.80072018
54Systemic lupus erythematosus_Homo sapiens_hsa053220.78207753
55Tryptophan metabolism_Homo sapiens_hsa003800.78205133
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77451278
57Nicotine addiction_Homo sapiens_hsa050330.76846697
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76598065
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74752198
60Osteoclast differentiation_Homo sapiens_hsa043800.74694473
61Leishmaniasis_Homo sapiens_hsa051400.74493683
62Chemokine signaling pathway_Homo sapiens_hsa040620.68833001
63Glycerolipid metabolism_Homo sapiens_hsa005610.67605277
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66033280
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65063900
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62839894
67Arachidonic acid metabolism_Homo sapiens_hsa005900.59008678
68Dorso-ventral axis formation_Homo sapiens_hsa043200.58739593
69Epstein-Barr virus infection_Homo sapiens_hsa051690.57882081
70Influenza A_Homo sapiens_hsa051640.56526271
71TNF signaling pathway_Homo sapiens_hsa046680.55499719
72Peroxisome_Homo sapiens_hsa041460.53608096
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53160382
74Viral myocarditis_Homo sapiens_hsa054160.52988121
75Serotonergic synapse_Homo sapiens_hsa047260.52620974
76p53 signaling pathway_Homo sapiens_hsa041150.52571558
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49087894
78Purine metabolism_Homo sapiens_hsa002300.48627114
79Oxidative phosphorylation_Homo sapiens_hsa001900.47804201
80Collecting duct acid secretion_Homo sapiens_hsa049660.45878980
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45822372
82RNA transport_Homo sapiens_hsa030130.45454174
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.43837167
84Retinol metabolism_Homo sapiens_hsa008300.40896456
85Tuberculosis_Homo sapiens_hsa051520.40774344
86Pyrimidine metabolism_Homo sapiens_hsa002400.40189958
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39776508
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39342237
89Spliceosome_Homo sapiens_hsa030400.39171605
90Proteasome_Homo sapiens_hsa030500.38272661
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36527851
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35813872
93Propanoate metabolism_Homo sapiens_hsa006400.35057571
94Calcium signaling pathway_Homo sapiens_hsa040200.33402484
95Mismatch repair_Homo sapiens_hsa034300.32279110
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.32249252
97Viral carcinogenesis_Homo sapiens_hsa052030.31180469
98African trypanosomiasis_Homo sapiens_hsa051430.29200883
99Toxoplasmosis_Homo sapiens_hsa051450.29152188
100Platelet activation_Homo sapiens_hsa046110.28959489

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