ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	meiotic chromosome segregation (GO:0045132)	6.31308256
2	rRNA catabolic process (GO:0016075)	4.68180164
3	L-fucose metabolic process (GO:0042354)	4.65491490
4	L-fucose catabolic process (GO:0042355)	4.65491490
5	fucose catabolic process (GO:0019317)	4.65491490
6	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.47263683
7	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.47263683
8	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.47263683
9	protein K11-linked deubiquitination (GO:0035871)	4.44048789
10	rRNA methylation (GO:0031167)	4.16333087
11	regulation of glucokinase activity (GO:0033131)	3.98593566
12	regulation of hexokinase activity (GO:1903299)	3.98593566
13	DNA replication checkpoint (GO:0000076)	3.96932468
14	response to pheromone (GO:0019236)	3.84971783
15	cellular response to ATP (GO:0071318)	3.73137980
16	DNA double-strand break processing (GO:0000729)	3.72643448
17	regulation of DNA endoreduplication (GO:0032875)	3.68355822
18	reciprocal DNA recombination (GO:0035825)	3.63069711
19	reciprocal meiotic recombination (GO:0007131)	3.63069711
20	somite development (GO:0061053)	3.62573549
21	nephron tubule morphogenesis (GO:0072078)	3.58296608
22	nephron epithelium morphogenesis (GO:0072088)	3.58296608
23	histone H3-K4 trimethylation (GO:0080182)	3.54282938
24	rRNA modification (GO:0000154)	3.48683294
25	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.42220953
26	double-strand break repair via homologous recombination (GO:0000724)	3.42009845
27	peptidyl-histidine modification (GO:0018202)	3.36974458
28	recombinational repair (GO:0000725)	3.36673114
29	ncRNA catabolic process (GO:0034661)	3.36627168
30	water-soluble vitamin biosynthetic process (GO:0042364)	3.33122524
31	axoneme assembly (GO:0035082)	3.32097958
32	peptidyl-threonine dephosphorylation (GO:0035970)	3.31032614
33	pancreas development (GO:0031016)	3.30342270
34	establishment of protein localization to Golgi (GO:0072600)	3.28097581
35	replication fork processing (GO:0031297)	3.27964641
36	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.27177528
37	auditory receptor cell differentiation (GO:0042491)	3.22219817
38	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.17471394
39	photoreceptor cell maintenance (GO:0045494)	3.16218685
40	protein targeting to Golgi (GO:0000042)	3.15738218
41	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.14665377
42	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.12314178
43	cellular ketone body metabolic process (GO:0046950)	3.09782076
44	positive regulation of histone H3-K4 methylation (GO:0051571)	3.07458362
45	inner ear receptor stereocilium organization (GO:0060122)	3.05764690
46	respiratory chain complex IV assembly (GO:0008535)	3.02535215
47	protein localization to Golgi apparatus (GO:0034067)	2.98483957
48	cornea development in camera-type eye (GO:0061303)	2.96263613
49	anterograde synaptic vesicle transport (GO:0048490)	2.91853894
50	ketone body metabolic process (GO:1902224)	2.80957395
51	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.80492935
52	translesion synthesis (GO:0019985)	2.79701024
53	S-adenosylmethionine metabolic process (GO:0046500)	2.79551568
54	regulation of mesoderm development (GO:2000380)	2.76833571
55	nucleotide transmembrane transport (GO:1901679)	2.76670160
56	cilium morphogenesis (GO:0060271)	2.75232114
57	DNA integration (GO:0015074)	2.75202067
58	detection of light stimulus involved in visual perception (GO:0050908)	2.74234154
59	detection of light stimulus involved in sensory perception (GO:0050962)	2.74234154
60	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.73967534
61	kidney morphogenesis (GO:0060993)	2.73650062
62	postreplication repair (GO:0006301)	2.72935766
63	epithelial cilium movement (GO:0003351)	2.72744934
64	adaptation of signaling pathway (GO:0023058)	2.71371224
65	protein K63-linked deubiquitination (GO:0070536)	2.71132767
66	renal tubule morphogenesis (GO:0061333)	2.70970064
67	response to nitrosative stress (GO:0051409)	2.69778034
68	heme transport (GO:0015886)	2.69707036
69	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.66200373
70	glycosphingolipid biosynthetic process (GO:0006688)	2.64845617
71	cytochrome complex assembly (GO:0017004)	2.62952958
72	pericardium development (GO:0060039)	2.62176381
73	tryptophan catabolic process (GO:0006569)	2.60851444
74	indole-containing compound catabolic process (GO:0042436)	2.60851444
75	indolalkylamine catabolic process (GO:0046218)	2.60851444
76	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.58672749
77	retinal cone cell development (GO:0046549)	2.57595833
78	synapsis (GO:0007129)	2.56247808
79	regulation of triglyceride biosynthetic process (GO:0010866)	2.55870854
80	behavioral response to nicotine (GO:0035095)	2.53279637
81	photoreceptor cell development (GO:0042461)	2.51638407
82	peptidyl-lysine trimethylation (GO:0018023)	2.49984269
83	platelet dense granule organization (GO:0060155)	2.49912929
84	neuron fate determination (GO:0048664)	2.49845783
85	signal peptide processing (GO:0006465)	2.49003476
86	snRNA processing (GO:0016180)	2.48832103
87	DNA strand renaturation (GO:0000733)	2.48418053
88	C-terminal protein amino acid modification (GO:0018410)	2.47359451
89	indolalkylamine metabolic process (GO:0006586)	2.45266173
90	visual perception (GO:0007601)	2.44211154
91	kynurenine metabolic process (GO:0070189)	2.44186131
92	sensory perception of light stimulus (GO:0050953)	2.44064618
93	negative regulation of execution phase of apoptosis (GO:1900118)	2.43767856
94	inositol phosphate dephosphorylation (GO:0046855)	2.43553492
95	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.43553492
96	Golgi to endosome transport (GO:0006895)	2.43482943
97	limb bud formation (GO:0060174)	2.42774138
98	lens development in camera-type eye (GO:0002088)	2.42539719
99	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.42262329
100	regulation of meiosis I (GO:0060631)	2.41830385

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.29259128
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.25085740
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.89465269
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.79889310
5	EWS_26573619_Chip-Seq_HEK293_Human	2.77989980
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.62278137
7	VDR_22108803_ChIP-Seq_LS180_Human	2.62034302
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.52400549
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.47368183
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.46314881
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.45676575
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40685874
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.35435258
14	FUS_26573619_Chip-Seq_HEK293_Human	2.34867399
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.34620140
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.31825302
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15092887
18	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.14292369
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.07063668
20	P300_19829295_ChIP-Seq_ESCs_Human	2.00852802
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82628199
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.72110501
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.70806858
24	TCF4_23295773_ChIP-Seq_U87_Human	1.69340684
25	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68607151
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66321855
27	STAT3_23295773_ChIP-Seq_U87_Human	1.65630589
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.65620434
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61015880
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.58097844
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58097844
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.55314504
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.55272350
34	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.53183049
35	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.48802196
36	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.48752294
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.48324304
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.47878094
39	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.46106926
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.44736976
41	AR_21572438_ChIP-Seq_LNCaP_Human	1.44008652
42	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.43544462
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.43532474
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42337979
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41179301
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.39308870
47	AR_25329375_ChIP-Seq_VCAP_Human	1.39032187
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37815251
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37702857
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36537431
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.33907166
52	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.31199511
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31170197
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31170197
55	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.29966242
56	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.28615395
57	ELK1_19687146_ChIP-ChIP_HELA_Human	1.25757357
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25569132
59	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.23518904
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.23293902
61	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23179846
62	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.22644855
63	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.22529124
64	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22529124
65	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.22066534
66	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.21410139
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.21154600
68	MYC_18940864_ChIP-ChIP_HL60_Human	1.20773940
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.20561132
70	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.20465713
71	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18161868
72	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18010845
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17101162
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.15973417
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.15973417
76	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15651835
77	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13917789
78	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13878725
79	IGF1R_20145208_ChIP-Seq_DFB_Human	1.12941771
80	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.12020717
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.11955407
82	CDX2_22108803_ChIP-Seq_LS180_Human	1.10883904
83	TCF4_22108803_ChIP-Seq_LS180_Human	1.10271848
84	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.09644169
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09020675
86	TBL1_22424771_ChIP-Seq_293T_Human	1.07283515
87	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06307343
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06227071
89	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.06109669
90	NFYB_21822215_ChIP-Seq_K562_Human	1.03359302
91	VDR_23849224_ChIP-Seq_CD4+_Human	1.00841705
92	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00380998
93	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.99113660
94	P300_18555785_Chip-Seq_ESCs_Mouse	0.99043856
95	AR_20517297_ChIP-Seq_VCAP_Human	0.98291914
96	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.97796953
97	ETV1_20927104_ChIP-Seq_GIST48_Human	0.97786101
98	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.97658373
99	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96895237
100	PHF8_20622853_ChIP-Seq_HELA_Human	0.96435856

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.61787288
2	MP0003787_abnormal_imprinting	3.38233146
3	MP0008877_abnormal_DNA_methylation	2.96795538
4	MP0005174_abnormal_tail_pigmentation	2.92383891
5	MP0005171_absent_coat_pigmentation	2.69326766
6	MP0008057_abnormal_DNA_replication	2.63551637
7	MP0002102_abnormal_ear_morphology	2.50236378
8	MP0006292_abnormal_olfactory_placode	2.35559686
9	MP0003136_yellow_coat_color	2.35160157
10	MP0000569_abnormal_digit_pigmentation	2.34874068
11	MP0002009_preneoplasia	2.28145310
12	MP0006072_abnormal_retinal_apoptosis	2.20299704
13	MP0005551_abnormal_eye_electrophysiolog	2.18428531
14	MP0001986_abnormal_taste_sensitivity	2.05180431
15	MP0005084_abnormal_gallbladder_morpholo	1.94902310
16	MP0002928_abnormal_bile_duct	1.91881330
17	MP0002837_dystrophic_cardiac_calcinosis	1.74471935
18	MP0005253_abnormal_eye_physiology	1.72306770
19	MP0004043_abnormal_pH_regulation	1.71695280
20	MP0004145_abnormal_muscle_electrophysio	1.71380457
21	MP0005220_abnormal_exocrine_pancreas	1.64290725
22	MP0010678_abnormal_skin_adnexa	1.54217944
23	MP0004147_increased_porphyrin_level	1.53733206
24	MP0002234_abnormal_pharynx_morphology	1.52510306
25	MP0009697_abnormal_copulation	1.50854464
26	MP0010386_abnormal_urinary_bladder	1.49516347
27	MP0002938_white_spotting	1.48677181
28	MP0009780_abnormal_chondrocyte_physiolo	1.46837186
29	MP0005379_endocrine/exocrine_gland_phen	1.43665575
30	MP0005646_abnormal_pituitary_gland	1.43553697
31	MP0008875_abnormal_xenobiotic_pharmacok	1.42507175
32	MP0003646_muscle_fatigue	1.42377617
33	MP0005360_urolithiasis	1.41805167
34	MP0000631_abnormal_neuroendocrine_gland	1.41730842
35	MP0000427_abnormal_hair_cycle	1.41002149
36	MP0000372_irregular_coat_pigmentation	1.39601972
37	MP0006054_spinal_hemorrhage	1.39489444
38	MP0000383_abnormal_hair_follicle	1.39023124
39	MP0003122_maternal_imprinting	1.36562565
40	MP0008789_abnormal_olfactory_epithelium	1.34669892
41	MP0004885_abnormal_endolymph	1.34105981
42	MP0003283_abnormal_digestive_organ	1.33359233
43	MP0002160_abnormal_reproductive_system	1.33037912
44	MP0003718_maternal_effect	1.32771338
45	MP0005085_abnormal_gallbladder_physiolo	1.29422298
46	MP0004215_abnormal_myocardial_fiber	1.27021259
47	MP0002139_abnormal_hepatobiliary_system	1.26829195
48	MP0003121_genomic_imprinting	1.23959282
49	MP0004133_heterotaxia	1.23559864
50	MP0005187_abnormal_penis_morphology	1.23176140
51	MP0000015_abnormal_ear_pigmentation	1.22662853
52	MP0003950_abnormal_plasma_membrane	1.21930480
53	MP0002876_abnormal_thyroid_physiology	1.17594693
54	MP0003937_abnormal_limbs/digits/tail_de	1.13958693
55	MP0001756_abnormal_urination	1.12786450
56	MP0002163_abnormal_gland_morphology	1.12239941
57	MP0003045_fibrosis	1.10217499
58	MP0009745_abnormal_behavioral_response	1.09892564
59	MP0002638_abnormal_pupillary_reflex	1.09422607
60	MP0005332_abnormal_amino_acid	1.09200751
61	MP0005365_abnormal_bile_salt	1.08773496
62	MP0001299_abnormal_eye_distance/	1.08382258
63	MP0008872_abnormal_physiological_respon	1.07241610
64	MP0009053_abnormal_anal_canal	1.06841354
65	MP0001764_abnormal_homeostasis	1.06389763
66	MP0005423_abnormal_somatic_nervous	1.05346847
67	MP0005389_reproductive_system_phenotype	1.03903062
68	MP0003137_abnormal_impulse_conducting	0.99837731
69	MP0005395_other_phenotype	0.99391061
70	MP0002168_other_aberrant_phenotype	0.97831558
71	MP0002735_abnormal_chemical_nociception	0.97769982
72	MP0001944_abnormal_pancreas_morphology	0.97428007
73	MP0005195_abnormal_posterior_eye	0.97088276
74	MP0009046_muscle_twitch	0.96895232
75	MP0005408_hypopigmentation	0.95805260
76	MP0004484_altered_response_of	0.94619632
77	MP0008058_abnormal_DNA_repair	0.92715919
78	MP0002233_abnormal_nose_morphology	0.91854386
79	MP0001270_distended_abdomen	0.90270930
80	MP0006036_abnormal_mitochondrial_physio	0.89853435
81	MP0003890_abnormal_embryonic-extraembry	0.88783087
82	MP0002693_abnormal_pancreas_physiology	0.86349095
83	MP0001324_abnormal_eye_pigmentation	0.84529488
84	MP0005386_behavior/neurological_phenoty	0.83381950
85	MP0004924_abnormal_behavior	0.83381950
86	MP0005367_renal/urinary_system_phenotyp	0.83322730
87	MP0000516_abnormal_urinary_system	0.83322730
88	MP0001929_abnormal_gametogenesis	0.82375868
89	MP0003755_abnormal_palate_morphology	0.81621137
90	MP0002095_abnormal_skin_pigmentation	0.80740182
91	MP0002138_abnormal_hepatobiliary_system	0.80568589
92	MP0010329_abnormal_lipoprotein_level	0.80489337
93	MP0005499_abnormal_olfactory_system	0.79947481
94	MP0005394_taste/olfaction_phenotype	0.79947481
95	MP0001286_abnormal_eye_development	0.78671763
96	MP0003011_delayed_dark_adaptation	0.77981787
97	MP0002210_abnormal_sex_determination	0.77212923
98	MP0010094_abnormal_chromosome_stability	0.76982379
99	MP0003943_abnormal_hepatobiliary_system	0.76904641
100	MP0001968_abnormal_touch/_nociception	0.75913328

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	4.27034193
2	Pancreatic cysts (HP:0001737)	4.01131951
3	True hermaphroditism (HP:0010459)	3.90771119
4	Congenital stationary night blindness (HP:0007642)	3.69315124
5	Attenuation of retinal blood vessels (HP:0007843)	3.50789928
6	Rib fusion (HP:0000902)	3.28658731
7	Decreased circulating renin level (HP:0003351)	3.25691476
8	Intestinal atresia (HP:0011100)	3.21829592
9	Abnormal biliary tract physiology (HP:0012439)	3.20948964
10	Bile duct proliferation (HP:0001408)	3.20948964
11	Hyperkalemia (HP:0002153)	3.03759168
12	Tubular atrophy (HP:0000092)	3.00649423
13	Bony spicule pigmentary retinopathy (HP:0007737)	2.84232738
14	Abnormality of midbrain morphology (HP:0002418)	2.73897080
15	Molar tooth sign on MRI (HP:0002419)	2.73897080
16	Chronic hepatic failure (HP:0100626)	2.72172970
17	Nephronophthisis (HP:0000090)	2.71572535
18	Abnormality of the renal cortex (HP:0011035)	2.70354605
19	Albinism (HP:0001022)	2.69328131
20	Abnormal rod and cone electroretinograms (HP:0008323)	2.66488046
21	Supernumerary spleens (HP:0009799)	2.61557295
22	Abnormality of the renal medulla (HP:0100957)	2.55478554
23	Colon cancer (HP:0003003)	2.54902815
24	Progressive inability to walk (HP:0002505)	2.52685681
25	Cystic liver disease (HP:0006706)	2.48732060
26	Zonular cataract (HP:0010920)	2.47518422
27	Medial flaring of the eyebrow (HP:0010747)	2.46520169
28	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.45430972
29	Abnormality of DNA repair (HP:0003254)	2.41251217
30	Dyschromatopsia (HP:0007641)	2.40318125
31	Abnormal biliary tract morphology (HP:0012440)	2.40216172
32	Hypoplasia of the pons (HP:0012110)	2.40026386
33	Decreased central vision (HP:0007663)	2.38617864
34	Poikiloderma (HP:0001029)	2.33061906
35	Pendular nystagmus (HP:0012043)	2.30512106
36	Anencephaly (HP:0002323)	2.27424414
37	Tented upper lip vermilion (HP:0010804)	2.25814260
38	Polydipsia (HP:0001959)	2.24658859
39	Abnormal drinking behavior (HP:0030082)	2.24658859
40	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.21660118
41	Asplenia (HP:0001746)	2.20624071
42	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.20613395
43	Chorioretinal atrophy (HP:0000533)	2.18574355
44	Abnormality of the pons (HP:0007361)	2.17899947
45	Ectopic kidney (HP:0000086)	2.16693214
46	Sensory axonal neuropathy (HP:0003390)	2.15060216
47	Hypoplastic iliac wings (HP:0002866)	2.14862655
48	Adrenal hypoplasia (HP:0000835)	2.14529412
49	Congenital hepatic fibrosis (HP:0002612)	2.12490965
50	Exertional dyspnea (HP:0002875)	2.10769095
51	Methylmalonic acidemia (HP:0002912)	2.10259645
52	Severe visual impairment (HP:0001141)	2.09982760
53	Biliary tract neoplasm (HP:0100574)	2.09962578
54	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.06126279
55	Congenital primary aphakia (HP:0007707)	2.04797801
56	Gait imbalance (HP:0002141)	2.03227747
57	Abnormal albumin level (HP:0012116)	2.01147676
58	Hypoalbuminemia (HP:0003073)	2.01147676
59	Postaxial foot polydactyly (HP:0001830)	2.00422641
60	Furrowed tongue (HP:0000221)	2.00260102
61	Gastrointestinal atresia (HP:0002589)	1.97891334
62	Thyroiditis (HP:0100646)	1.95807976
63	Abnormality of the metopic suture (HP:0005556)	1.92882234
64	Small hand (HP:0200055)	1.89592390
65	Choroideremia (HP:0001139)	1.88764228
66	Hematochezia (HP:0002573)	1.84426032
67	Renal cortical cysts (HP:0000803)	1.83868617
68	Congenital sensorineural hearing impairment (HP:0008527)	1.83636027
69	Sloping forehead (HP:0000340)	1.83413099
70	Prominent metopic ridge (HP:0005487)	1.83174837
71	Absent thumb (HP:0009777)	1.81680919
72	Pancreatic islet-cell hyperplasia (HP:0004510)	1.80828865
73	Lipid accumulation in hepatocytes (HP:0006561)	1.80661666
74	Hyperinsulinemic hypoglycemia (HP:0000825)	1.80605430
75	Constricted visual fields (HP:0001133)	1.79618611
76	Cerebellar dysplasia (HP:0007033)	1.79508974
77	Poor coordination (HP:0002370)	1.78824683
78	Occipital encephalocele (HP:0002085)	1.78129119
79	Abnormality of vitamin B metabolism (HP:0004340)	1.77989398
80	Febrile seizures (HP:0002373)	1.77389101
81	Gaze-evoked nystagmus (HP:0000640)	1.76132202
82	Male pseudohermaphroditism (HP:0000037)	1.75356355
83	Pigmentary retinal degeneration (HP:0001146)	1.72407882
84	Nephrogenic diabetes insipidus (HP:0009806)	1.72078136
85	Large for gestational age (HP:0001520)	1.71238828
86	Abnormality of the ileum (HP:0001549)	1.71000279
87	Abnormality of chromosome stability (HP:0003220)	1.70443935
88	Sclerocornea (HP:0000647)	1.69043842
89	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.67486735
90	Hypophosphatemic rickets (HP:0004912)	1.66965247
91	Neoplasm of the adrenal cortex (HP:0100641)	1.66754919
92	Polyuria (HP:0000103)	1.66630370
93	Increased hepatocellular lipid droplets (HP:0006565)	1.66034522
94	Increased circulating renin level (HP:0000848)	1.65555340
95	Hyperlipoproteinemia (HP:0010980)	1.63234499
96	Inability to walk (HP:0002540)	1.62885843
97	Astigmatism (HP:0000483)	1.62230254
98	Genital tract atresia (HP:0001827)	1.62091003
99	Abnormality of macular pigmentation (HP:0008002)	1.61492642
100	Oligohydramnios (HP:0001562)	1.60992952

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.45362423
2	BMPR1B	4.15527734
3	ACVR1B	3.91444596
4	MST4	2.60084347
5	TNIK	2.44414235
6	BRSK2	2.42331622
7	NUAK1	2.28150580
8	STK38L	2.20338834
9	CAMKK2	2.08283029
10	DYRK3	1.97760372
11	GRK1	1.97643826
12	ZAK	1.97251969
13	NTRK3	1.89740209
14	BLK	1.87564953
15	WNK4	1.86592400
16	TRIM28	1.82751432
17	TLK1	1.64032047
18	MUSK	1.56910743
19	WNK3	1.47204088
20	PINK1	1.45010281
21	STK39	1.41229481
22	PLK2	1.39083465
23	TGFBR1	1.37743447
24	AKT3	1.35920088
25	ADRBK2	1.31476927
26	STK3	1.26162343
27	CAMK1G	1.25408825
28	EIF2AK3	1.22637757
29	MELK	1.21820217
30	PNCK	1.21807317
31	MAP2K6	1.20402069
32	MKNK2	1.19876494
33	ERBB3	1.19220345
34	TAOK3	1.19156319
35	INSRR	1.13733052
36	MAP3K4	1.11785659
37	CAMK1D	1.10056324
38	CASK	1.08034333
39	PRKCE	1.05549860
40	STK24	1.01875917
41	PHKG1	0.99814090
42	PHKG2	0.99814090
43	RIPK1	0.96016467
44	WEE1	0.90152580
45	CCNB1	0.88653328
46	NLK	0.88012548
47	CDK9	0.85997670
48	MAPK15	0.85271044
49	EPHA4	0.84429111
50	MAP3K9	0.82591912
51	MAPKAPK5	0.82385671
52	OXSR1	0.79971374
53	FGFR2	0.77803867
54	RPS6KA4	0.77352305
55	CDK8	0.76861331
56	FLT3	0.76682142
57	PLK3	0.75890398
58	CHEK2	0.72377989
59	MAPK13	0.71919229
60	NEK1	0.70494184
61	OBSCN	0.65340807
62	PIK3CG	0.64896179
63	ADRBK1	0.63503397
64	NEK2	0.60958091
65	BRSK1	0.60198958
66	LATS1	0.58847771
67	PLK4	0.58419601
68	ATR	0.56473232
69	PLK1	0.56022971
70	MAP3K12	0.55015205
71	TAF1	0.53702380
72	JAK3	0.49278606
73	NTRK2	0.48898208
74	ATM	0.48711462
75	MAP2K7	0.48635446
76	PRKAA1	0.48581255
77	TRPM7	0.46280233
78	MARK3	0.45990350
79	ROCK1	0.45166466
80	CSNK1G2	0.44622596
81	PRKCQ	0.44204572
82	CAMK4	0.42934963
83	SGK2	0.42657597
84	DAPK2	0.42529036
85	PTK2B	0.41029583
86	PKN1	0.40421293
87	CSNK1A1	0.40024200
88	MAPKAPK3	0.39157501
89	PRKCI	0.38953185
90	PRKCG	0.36685402
91	CSNK1G3	0.35907383
92	CSNK1A1L	0.35557330
93	MAP4K2	0.35157736
94	CSNK1G1	0.35107901
95	CLK1	0.34930312
96	PAK3	0.33760438
97	VRK1	0.33161305
98	RPS6KB1	0.32399097
99	MAP3K2	0.32007579
100	MAP2K1	0.31607292

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.11157396
2	Protein export_Homo sapiens_hsa03060	3.10786546
3	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.07171938
4	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.80622121
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.76427993
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.58291122
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.55842272
8	Basal transcription factors_Homo sapiens_hsa03022	2.50285977
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.34209699
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.27010341
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.23372213
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.23042380
13	Propanoate metabolism_Homo sapiens_hsa00640	2.17542000
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.14381692
15	Circadian rhythm_Homo sapiens_hsa04710	2.06217623
16	Homologous recombination_Homo sapiens_hsa03440	2.03478374
17	One carbon pool by folate_Homo sapiens_hsa00670	2.00333979
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.98262656
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.96486203
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.85944258
21	Regulation of autophagy_Homo sapiens_hsa04140	1.85404157
22	Sulfur metabolism_Homo sapiens_hsa00920	1.82554728
23	Caffeine metabolism_Homo sapiens_hsa00232	1.68036008
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.67632901
25	Olfactory transduction_Homo sapiens_hsa04740	1.57622804
26	Non-homologous end-joining_Homo sapiens_hsa03450	1.44264004
27	RNA degradation_Homo sapiens_hsa03018	1.40187398
28	Butanoate metabolism_Homo sapiens_hsa00650	1.39074100
29	Phototransduction_Homo sapiens_hsa04744	1.37666833
30	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.33393274
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.27402670
32	Sphingolipid metabolism_Homo sapiens_hsa00600	1.25820863
33	Lysine degradation_Homo sapiens_hsa00310	1.25330331
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.23854938
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.23227569
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.21290286
37	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.21125027
38	Steroid biosynthesis_Homo sapiens_hsa00100	1.19470093
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.14650604
40	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.11948510
41	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.09627282
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.06951489
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.05660184
44	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.00948143
45	ABC transporters_Homo sapiens_hsa02010	0.96336562
46	Basal cell carcinoma_Homo sapiens_hsa05217	0.90520703
47	Nucleotide excision repair_Homo sapiens_hsa03420	0.89140537
48	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.82098051
49	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.81929739
50	Oxidative phosphorylation_Homo sapiens_hsa00190	0.80110744
51	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.69710965
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.68179451
53	Mismatch repair_Homo sapiens_hsa03430	0.67437286
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66124188
55	Metabolic pathways_Homo sapiens_hsa01100	0.65975881
56	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65833959
57	Insulin secretion_Homo sapiens_hsa04911	0.65582180
58	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65106789
59	Morphine addiction_Homo sapiens_hsa05032	0.64998388
60	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.64079778
61	Peroxisome_Homo sapiens_hsa04146	0.63992896
62	Pyruvate metabolism_Homo sapiens_hsa00620	0.61884278
63	Retinol metabolism_Homo sapiens_hsa00830	0.60903611
64	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.60220868
65	Fatty acid degradation_Homo sapiens_hsa00071	0.59562321
66	Nicotine addiction_Homo sapiens_hsa05033	0.59110458
67	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57866674
68	Base excision repair_Homo sapiens_hsa03410	0.56327933
69	RNA transport_Homo sapiens_hsa03013	0.53860436
70	Purine metabolism_Homo sapiens_hsa00230	0.53037767
71	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52598886
72	Taste transduction_Homo sapiens_hsa04742	0.51158066
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50574242
74	Sulfur relay system_Homo sapiens_hsa04122	0.49725996
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.47498374
76	Hippo signaling pathway_Homo sapiens_hsa04390	0.47231420
77	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.45201341
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42495186
79	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.42014910
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.41179348
81	RNA polymerase_Homo sapiens_hsa03020	0.40798182
82	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.40762347
83	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.39982046
84	FoxO signaling pathway_Homo sapiens_hsa04068	0.39552613
85	Glucagon signaling pathway_Homo sapiens_hsa04922	0.39099766
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.39061668
87	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.38281144
88	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.37652305
89	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.34787053
90	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.34777777
91	Renin secretion_Homo sapiens_hsa04924	0.34681006
92	Serotonergic synapse_Homo sapiens_hsa04726	0.34365414
93	Glutamatergic synapse_Homo sapiens_hsa04724	0.34308236
94	Histidine metabolism_Homo sapiens_hsa00340	0.34289903
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34102428
96	Mineral absorption_Homo sapiens_hsa04978	0.30192358
97	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.28810478
98	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.25998413
99	Pyrimidine metabolism_Homo sapiens_hsa00240	0.25947707
100	Arginine and proline metabolism_Homo sapiens_hsa00330	0.25732607

ZNF101P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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